Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| regulation of enzymes by ligand induced change in polymerization. | 1986 | 3020906 | |
| on the spin trapping and esr detection of oxygen-derived radicals generated inside cells. | recently several attempts to identify oxygen-derived radicals in whole cells by spin trapping and electron spin resonance have been reported by using 5,5-dimethyl-1-pyrroline-n-oxide as the spin trap. in the present study, the feasibility of this method is examined. chinese hamster v79 cells and human erythrocytes served as the test systems, while oh radicals were generated by gamma radiolysis. several spin traps were used to scavange the radicals and a distinction between exo- and endocellular ... | 1986 | 3020550 |
| on the spin trapping and esr detection of oxygen-derived radicals generated inside cells. | recently several attempts to identify oxygen-derived radicals in whole cells by spin trapping and electron spin resonance have been reported by using 5,5-dimethyl-1-pyrroline-n-oxide as the spin trap. in the present study, the feasibility of this method is examined. chinese hamster v79 cells and human erythrocytes served as the test systems, while oh radicals were generated by gamma radiolysis. several spin traps were used to scavange the radicals and a distinction between exo- and endocellular ... | 1986 | 3020550 |
| chronic antidepressant treatment reduces central beta-adrenoceptor sensitivity in a behavioural test. | the ability of beta-adrenoceptor agonists to potentiate the head-twitch response to 5-hydroxytryptophan (5-htp) in mice was used to assess the in vivo sensitivity of beta-adrenoceptors 48 h after cessation of acute or chronic administration of desmethylimipramine (dmi) or iprindole (ipd). neither acute nor chronic antidepressant administration significantly altered the head-twitch response to 5-htp alone. forty-eight hours after withdrawal from chronic but not acute pretreatment with dmi or ipd ... | 2010 | 3019728 |
| chronic antidepressant treatment reduces central beta-adrenoceptor sensitivity in a behavioural test. | the ability of beta-adrenoceptor agonists to potentiate the head-twitch response to 5-hydroxytryptophan (5-htp) in mice was used to assess the in vivo sensitivity of beta-adrenoceptors 48 h after cessation of acute or chronic administration of desmethylimipramine (dmi) or iprindole (ipd). neither acute nor chronic antidepressant administration significantly altered the head-twitch response to 5-htp alone. forty-eight hours after withdrawal from chronic but not acute pretreatment with dmi or ipd ... | 2010 | 3019728 |
| isolation and buoyant density of pneumocystis carinii in percoll gradients. | a new gradient material, percoll, a collodial suspension of silica particles covered with polyvinylpyrolidon, has been used to isolate pneumocystis carinii from infected rat and human lung tissues. the specific gravity of pneumocystis carinii was shown to be within the range of 1.018-1.062 g/ml with most pneumocysts within 1.033-1.049 g/ml. | 1985 | 3001637 |
| the affinity of (-)-propranolol for beta 1- and beta 2-adrenoceptors of human heart. differential antagonism of the positive inotropic effects and adenylate cyclase stimulation by (-)-noradrenaline and (-)-adrenaline. | an appraisal of the affinity of (-)-propranolol was made for beta-adrenoceptors of isolated heart preparations and myocardial membrane particles from patients undergoing open heart surgery. in order to eliminate possible distorting influences of neuronal and extraneuronal uptakes of catecholamines on the affinity estimates for (-)-propranolol, isolated tissues were pretreated once with 5 or 10 mumol/l phenoxybenzamine for 2 h. phenoxybenzamine caused potentiation of the positive inotropic effect ... | 1985 | 2999616 |
| regulation of the glucose phosphotransferase system in brochothrix thermosphacta by membrane energization. | uptake of 2-deoxyglucose, alpha-methylglucopyranoside, and glucose into intact cells of brochothrix thermosphacta (formerly microbacterium thermosphactum, atcc 11509) was stimulated by kcn or cccp. the glucose analogs were recovered almost totally as the sugar phosphates. membrane vesicles were isolated from protoplasts and shown to be right side out by freeze fracturing and by using atpase as a marker for the cytoplasmic membrane surface. uptake of glucose into vesicles was dependent on the pre ... | 1985 | 2995314 |
| metabolic zonation in liver of diabetic rats. zonal distribution of phosphoenolpyruvate carboxykinase, pyruvate kinase, glucose-6-phosphatase and succinate dehydrogenase. | the activities and zonal distribution of key enzymes of carbohydrate metabolism were studied in livers of diabetic rats. 48 h after alloxan treatment the following alterations were observed, intermediate values being reached after 24 h: blood glucose, acetoacetate and beta-hydroxybutyrate were increased to more than 500%; liver glycogen was reduced to about 10%. portal vein insulin was reduced to below 10%, portal glucagon was increased to almost 200%. the glucogenic enzymes phosphoenolpyruvate ... | 1985 | 2988584 |
| structural and serological heterogeneity of gamma/delta t cell antigen receptor expression in thymus and peripheral blood. | monoclonal antibodies (mab) reactive against the gamma/delta t cell antigen receptor (tcr) have been used to characterize the distribution and structural properties of gamma/delta tcr-bearing lymphocytes in blood and thymus. consistent with prior reports the tcr gamma/delta-1 and delta-1 mab react with all gamma/delta tcr+ t lymphocytes in blood and thymus. by contrast the tcs-delta mab was found only to react with a subset of the gamma/delta tcr-bearing t cell population. several lines of evide ... | 1988 | 2975598 |
| [provocation tests in coronary artery spasm]. | 2010 | 2950442 | |
| correction of iatrogenic floating toe following resection of the base of the proximal phalanx. | for many decades, resecting the base of the proximal phalanx was a popular method of correcting hammertoes. the long-term result of the procedure, however, is a flail, proximally retracted, "floating" toe. correction of this challenging surgical problem can be accomplished with a v-y advancement flap and specific releases. | 2010 | 2937523 |
| fatty acid composition of platelets and of plasma lipid esters in relation to platelet function in patients with ischaemic heart disease. | serum lipoproteins, fatty acids in plasma lipid esters and in platelet phospholipids were assessed in 64 patients with ischaemic heart disease (ihd) and in 67 controls. hyperlipoproteinemia (hlp) (vldl triglycerides greater than 1.4 mmol/l and/or ldl cholesterol greater than 5.2 mmol/l) was found in 64% of the patients. in the plasma lipid esters the relative concentrations of saturated and monounsaturated fatty acids as well as dihomo-gammalinolenic acid were higher in the ihd patients whereas ... | 2010 | 2936356 |
| cellular effects of hematoporphyrin derivative photodynamic therapy on normal and neoplastic rat bladder cells. | hpd is known to localize in neoplastic cells and when exposed to the appropriate wavelength of light causes cytotoxicity. the authors have established a rat urothelial cell model for use in comparing and contrasting the effects of hpd photodynamic therapy (pdt) in normal (rbl-01) and transitional cell carcinoma (ay27) bladder cell lines. uptake, toxicity, and morphologic damage following exposure to hpd pdt were evaluated. trypan blue exclusion was used for determination of the toxicity of sever ... | 1986 | 2936252 |
| [changes in the level of endogenous heparin and various indicators of hemostasis in late pregnancy toxemias]. | 2010 | 2935011 | |
| berger's disease without iga deposits? | 2010 | 2918964 | |
| comparison of toxic effects of methylguanidine, guanidinosuccinic acid and creatinine in rats with adenine-induced chronic renal failure. | methylguanidine (mg), guanidinosuccinic acid (gsa) and creatinine (cr), which accumulate in the body in parallel with the progress of renal failure after adenine administration, were given separately to rats in order to compare their toxicities. food containing adenine was given to rats for 24 days to induce renal failure, and then each of the test substances was administered intraperitoneally from the following day, the survival rates of the rats being subsequently determined. administration of ... | 1989 | 2918950 |
| [adult t-cell leukemia associated with htlv1 and positive hiv2 serology in an african woman]. | we report a case of acute adult t-cell leukemia associated with htlv1 infection in a young african woman. the leukemic proliferation consisted of cd4-, cd25-positive lymphoid cells with typically convoluted nuclei and monoclonal integration of the htlv1-proviral dna. the clinical course was characterized by a rapid progression of the leukemia with development of hypercalcemia, resistance to chemotherapy, and the presence of multiple opportunistic infections. the additional finding of a seroposit ... | 1988 | 2898753 |
| [causes of death and follow-up in life insurance. 5 years' study]. | 2010 | 2873492 | |
| hypotensive effects after topical and intra-arterial administration of alpha-adrenergic agonists in isolated perfused rabbit eyes. | the influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (iop) was studied in isolated arterially perfused rabbit eyes. drugs were given intra-arterially or topically. with either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephrine, l-phenylephrine (alpha 1), or methoxamine (alpha 1), but there was an immediate ocular hypotensive effect. the alpha 2-agonist b-ht 920 caused a nonsignificant 1 mm hg fall in ... | 1985 | 2866480 |
| molecular cloning of rat phosphoprotein phosphatase 2a beta cdna and increased expressions of phosphatase 2a alpha and 2a beta in rat liver tumors. | a cdna clone coding for an isotype of the catalytic subunit of rat phosphoprotein phosphatase 2a was isolated. the deduced amino acid sequence of the clone was different at 8 positions from that of rat phosphatase 2a alpha determined in a previous study. the deduced amino acid sequence of the clone was, however, identical to that of human phosphatase 2a beta and differed only at one position from that of rabbit 2a beta. thus, the isolated cdna was identified as a clone coding for rat phosphatase ... | 1988 | 2849437 |
| opioids and behavior: genetic aspects. | three animal models, based on genetic differences in endogenous opioid peptides and opioid receptors, are described. obese mice and rats, whose pituitary opioid content is elevated, may be used to investigate eating disorders. recombinant inbred strains of mice, which differ in brain opioid receptors and analgesic responsiveness, can be used for study of opioid- and nonopioid-mediated mechanisms of pain inhibition. individual reactivity to opioids can be examined in c57bl/6 and dba/2 inbred stra ... | 1988 | 2837410 |
| renal failure due to enalapril and captopril in bilateral renal artery stenosis: greater awareness needed. | deterioration in renal function after the use of angiotensin converting-enzyme inhibitors may be the first clue to the presence of bilateral renal arterial stenosis. in order to avoid serious threat to the patient, early detection of the insidious decline in renal function is necessary and depends on routine biochemical monitoring after the initiation of therapy. six cases are described here, to illustrate the very real danger of this class of drugs in this chemical setting; the grave risk of th ... | 2010 | 2835640 |
| a morphologic and morphometric study of cells from colloid carcinoma of the breast obtained by fine needle aspiration. distinction from other breast lesions. | morphologic and morphometric studies were carried out on eight cases of pure and mixed colloid carcinoma of the breast initially diagnosed by fine needle aspiration (fna). key morphologic features included (1) cellular smears, (2) single cells, loose aggregates and cohesive groups of cells bathed in a mucinous background, (3) single cells displaying nuclear eccentricity and (4) little variation in nuclear size or shape, with bland-to-accentuated chromatin and rare nucleoli. these morphologic fea ... | 2010 | 2827410 |
| an ultrastructural study of pigeon bursa of fabricius during involution. | the ultrastructure of the pigeon bursa of fabricius during involution is described. according to the aa, the involutive process may be divided into 3 stages: an early involutive stage, a late involutive stage and a residual stage. the involutive process starts from epithelium later affecting the follicular medulla and all other structures of the organ. a mucoid degeneration can be observed, followed by an impressive fatty degeneration. | 2009 | 2817414 |
| relationship of serum selenium levels to tumor activity in acute non-lymphocytic leukemia. | serum selenium (se) levels were measured before, during and after high-dose induction chemotherapy in 70 patients with acute non-lymphocytic leukemia (anll). pre-treatment serum se levels were lower in patients than in controls (0.082 +/- 0.033 micrograms/ml versus 0.097 +/- 0.035 micrograms/ml, p less than 0.01). pretreatment serum se correlated inversely with the absolute peripheral blast cell count (r = -0.62, p less than 0.001) and other measurements of the tumor burden. seven days after the ... | 2009 | 2805230 |
| relationship of serum selenium levels to tumor activity in acute non-lymphocytic leukemia. | serum selenium (se) levels were measured before, during and after high-dose induction chemotherapy in 70 patients with acute non-lymphocytic leukemia (anll). pre-treatment serum se levels were lower in patients than in controls (0.082 +/- 0.033 micrograms/ml versus 0.097 +/- 0.035 micrograms/ml, p less than 0.01). pretreatment serum se correlated inversely with the absolute peripheral blast cell count (r = -0.62, p less than 0.001) and other measurements of the tumor burden. seven days after the ... | 2009 | 2805230 |
| early clinical results of the ttap acetabular cup. | one hundred seventy-five threaded titanium alloy prostheses (ttap) acetabular cups and 125 cemented cups were evaluated clinically and radiographically at 1 to 3 years postoperatively. the series was statistically different in that there were more women in the cemented group than in the non-cemented group (p less than .001). the cemented group was also older than the threaded group (p less than .001). pain, ambulation, function, range of motion, and roentgenograms were evaluated in all patients. ... | 2009 | 2798250 |
| early clinical results of the ttap acetabular cup. | one hundred seventy-five threaded titanium alloy prostheses (ttap) acetabular cups and 125 cemented cups were evaluated clinically and radiographically at 1 to 3 years postoperatively. the series was statistically different in that there were more women in the cemented group than in the non-cemented group (p less than .001). the cemented group was also older than the threaded group (p less than .001). pain, ambulation, function, range of motion, and roentgenograms were evaluated in all patients. ... | 2009 | 2798250 |
| unexpected, unexplained sudden death in young asthmatic subjects. | the clinical course of asthma in four patients younger than 25 years was considered. three died unexpectedly of their disease, and the fourth was successfully resuscitated after cardiopulmonary arrest. none of these patients met the criteria for status asthmaticus in the period preceding their death. the time course of the illness from apparent wellness to death was documented as seconds to minutes. no obvious cause of the severe disease was found at postmortem in two patients or by clinical ana ... | 2009 | 2791673 |
| [single photon emission computed tomography by using n-isopropyl-p-[123i]-iodoamphetamine and 99mtc-hexamethyl propyleneamine oxime in a patient with herpes simplex encephalitis]. | single photon emission computed tomographies (spects) by using n-isopropyl-p-[123i-imp]-iodo-amphetamine (123i-imp) and 99mtc-hexamethyl propyleneamine oxime (99mtc-hm-pao) were serially performed in a 70 yrs. old male with herpes simplex encephalitis (hse), and the chronological changes of accumulations were studied. accumulations of both 123i-imp and 99mtc-hm-pao increased initially, and then decreased with the stage of hse being advanced. the sequential appearance of the lesion in hse with 12 ... | 2009 | 2786584 |
| sympathetic uveitis after giant tear repair. | a 33-year-old hispanic man developed sympathetic ophthalmia 4.5 months after vitrectomy and repeat scleral buckling for a giant retinal tear in an aphakic previously traumatized eye. the patient had gray-white, subretinal nodules with characteristic changes of sympathetic uveitis detected by fluorescein angiography. the fluorescein angiographic and clinical findings revealed a dramatic response to steroid treatment: visual acuity returned to the previous 20/20 level within 5 weeks of therapy. | 1989 | 2772419 |
| childhood obsessive compulsive disorder: a two-year prospective follow-up of a community sample. | a 2-year prospective follow-up of a community-based sample of adolescents previously diagnosed as having obsessive compulsive disorder (ocd) or "obsessive compulsive spectrum" disorder and a control sample was completed by clinicians experienced with ocd but blind to prior diagnosis. an initial diagnosis of ocd or "other psychiatric disorder with oc features" was most likely to predict a diagnosis of ocd at follow-up. subclinical ocd at baseline did not strongly predict continuing psychopatholog ... | 2009 | 2768147 |
| tetrahydroaminoacridine and other allosteric antagonists of hippocampal m1 muscarine receptors. | tetrahydroaminoacridine (tha) and a variety of other nonclassical antagonists of muscarine receptors were studied for their ability to bind to primary and allosteric sites on muscarine receptors in rabbit hippocampal membranes. competition curves between 13 antagonists and 1 nm [3h]pirenzepine (kd = 3 nm) were simple mass action curves, but tha produced steeper curves, indicating positive cooperativity. nonetheless, tha inhibited the binding of low concentrations of [3h]pirenzepine, [3h]n-methyl ... | 1989 | 2725474 |
| identification of gram-positive coccal and coccobacillary vancomycin-resistant bacteria. | a total of 84 of 150 vancomycin-resistant (defined as no inhibition of bacterial growth around a 30-micrograms vancomycin disk placed on 5% sheep blood-trypticase soy agar [bbl microbiology systems, cockeysville, md.]) bacteria were definitively identified by determining the phenotypic criteria. the identity of representatives was also confirmed by dna-dna hybridizations. the following strains were identified: 1 enterococcus faecium, 18 leuconostoc mesenteroides, 15 leuconostoc citreum, 9 leucon ... | 1989 | 2723037 |
| studies on oxidized low density lipoproteins. controlled oxidation and a prostaglandin artifact. | low density lipoproteins (ldl), isolated by ultracentrifugal flotation, were oxidized (ldloxid) slowly during dialysis against 0.15 m nacl and subsequent incubation in 96% air-4% co2 at 37 degrees c. butylated hydroxytoluene prevented ldl oxidation. ldl preparations from different sera were oxidized at different rates and the degree of lipid peroxidation was controlled by varying the incubation time. mild oxidation did not alter the electrophoretic mobility of the ldloxid preparations. ldloxid c ... | 2009 | 2715720 |
| pulmonary edema localized in the right upper lobe accompanying mitral regurgitation. | focal patterns of pulmonary edema are confusing and often mistaken for the more common causes of focal lung disease, pneumonia, infarction, or aspiration. the authors report four cases of right upper lobe edema secondary to mitral regurgitation. the pathogenesis believed to be responsible for this condition is the vector of blood flow from the left ventricle to left atrium, which may be targeted at the right superior pulmonary vein, locally accentuating the forces for edema formation in the righ ... | 2009 | 2704804 |
| [guillain-barré syndrome and extramembranous glomerulopathy. apropos of a case]. | 2009 | 2696406 | |
| rational drug therapy based on understanding the pathophysiology of hypertension. | increased peripheral vascular resistance is the hemodynamic hallmark of chronic hypertension. evidence suggests that ca2+ is vital in mediating vasoconstrictive mechanisms. calcium channel blockers correct the specific arteriolar vasoconstrictive mechanism without unwanted compensatory actions. human primary hypertension may also be related to volume variations in which renal influences contribute to elevated arterial pressure and diuretics may be necessary to control the hypertension. patients ... | 1989 | 2663225 |
| [leukotrienes and lipoxins]. | 2009 | 2650889 | |
| control of escherichia coli populations by a combination of indigenous clostridia and lactobacilli in gnotobiotic mice and continuous-flow cultures. | the function of indigenous lactobacilli in the control of other intestinal microbial species is not clear. still more controversial is the effect of dietary bacterial supplements containing lactobacilli or other species. this situation is unlikely to change unless the mechanisms that control the colonization of ingested bacteria are better understood, and until more detailed information becomes available on the mechanisms by which certain populations of indigenous bacteria can affect the populat ... | 1989 | 2643576 |
| study of reaction time in hemiplegics. | visual reaction time and auditory reaction time (vrt and art) were measured in 25 right hemiplegics and 25 left hemiplegics in the age group of 40-60 years. there was a significant prolongation of vrt and art in both the right and left hemiplegics as compared to normals of the same age group. art following mono-aural stimulation i.e. sound input into the right and left ear separately, was also studied in the subjects. mono-aural stimulation revealed a prolongation of the art on contralateral sti ... | 2009 | 2634753 |
| [strabismus in children]. | 2008 | 2620724 | |
| [strabismus in children]. | 2008 | 2620724 | |
| an enzyme-linked immunosorbent assay for the quantitation of dna. | 1989 | 2607159 | |
| the next wave: the combination of clinical work with the opportunity to serve people makes dentistry an attractive career option for women. | 2008 | 2605768 | |
| diagnosis of infectious mononucleosis. | 2008 | 2592913 | |
| post-concussional symptoms following minor head injury. | the effect of admission to hospital after a minor head injury on the incidence and duration of post-concussional symptoms was investigated. a total of 114 adults with a minor head injury were randomly allocated to admission for 24 h or to discharge from the accident department. follow-up was by postal questionnaire. this revealed that 90 per cent of patients suffered symptoms lasting an average of 2 weeks. the patients who were discharged had symptoms that lasted a shorter time. admission to hos ... | 2007 | 2592090 |
| initiation and termination of human u1 rna transcription requires the concerted action of multiple flanking elements. | sequences in the 5' flanking region of small nuclear rna (snrna) genes are responsible for recognition of 3' end signals. formation of the pre-u1 3' end occurs at the downstream signal closest to the promoter, probably by transcription termination. we have analyzed promoter elements for their participation in formation of the 3' ends of pre-u1 rna. to do this, a human u1 rna gene with deletions in individual promoter elements was microinjected into xenopus laevis oocytes and the resulting rnas w ... | 1989 | 2587258 |
| pcr amplification of dna microdissected from a single polytene chromosome band: a comparison with conventional microcloning. | a novel alternative to microcloning for the production of region specific chromosomal dna is described. in this method, 'microamplification', single bands are dissected from polytene chromosomes and digested with sau3a. oligonucleotide adaptors are ligated to these fragments to provide convenient priming sites for polymerase chain reaction amplification. in this way, as much as 1 microgram of dna can be amplified from a single band. probes made from pcr amplified dna from two such dissections ha ... | 2008 | 2587252 |
| the polymorphic oxidation of beta-adrenoceptor antagonists. | 2008 | 2566179 | |
| hemodynamic and electrophysiologic effects of amlodipine, a new long-acting calcium antagonist: preliminary observations. | 2008 | 2530867 | |
| [multiple sclerosis in health care in our country: electrophysiological, immunological and clinical analysis]. | among 70 patients referred for suspected multiple sclerosis (ms) a total of 40 met criteria for definite (17), likely (12) or possible (11) diagnosis of the disease. visual evoked potentials provided evidence of cns lesion in 13 cases. abnormalities of somatosensory evoked potentials, particularly on stimulation of the posterior tibial nerve, were present in 90% of patients. brainstem auditory evoked potentials were of little use, contributing to diagnosis of one subclinical lesion; they were no ... | 2008 | 2519355 |
| heme-dependent and heme-independent nitrite reduction by lactic acid bacteria results in different n-containing products. | seventy strains of lactic acid bacteria were investigated for nitrite reductase activity. two types of this activity were detected. type i was found in lactobacillus plantarum, l. pentosus and pediococcus pentosaceus. this activity is heme-dependent with ammonia as the sole product. type ii mechanism is heme-independent and reduces nitrite to no and n2o. | 1990 | 2397159 |
| induction of transient hyperglycaemia in cancer patients. | serum glucose levels up to 700 mg/dl were achieved and maintained for 3 h in patients with advanced metastatic cancer by infusion of concentrated glucose solutions. even with infusions of large amounts of glucose, the maximum sustainable level of serum glucose did not exceed 700 mg/dl. the apparent ceiling of serum glucose level appeared to be due to a large and rapid loss of glucose from the kidneys. with adequate fluid volume replacement there was no rebound hypoglycaemia and there was no sign ... | 2008 | 2394924 |
| bismuth subsalicylate in the prevention of colonization of infant mice with campylobacter jejuni. | infant mice were used for the evaluation of the efficacy of bismuth subsalicylate (bss) in the prevention of the growth of campylobacter jejuni in the intestine. the mic90 of ten c. jejuni strains was 900 micrograms/ml. of three dosage regimens tested, continuous treatment before and after the bacterial challenge, mimicking the way bss is used in the prevention of traveller's diarrhoea, was the most effective. growth inhibition was dose dependent; the high dose of 2000 micrograms per day was mor ... | 1990 | 2347383 |
| adolescent medicine. | 2008 | 2329647 | |
| mapping the effects of motor cortex stimulation on somatosensory relay neurons in the rat thalamus: direct responses and afferent modulation. | single unit recordings were used to map the spatial distribution of motor (mi) cortical influences on thalamic somatosensory relay nuclei in the rat. a total of 215 microelectrode penetrations were made to record single neurons in tracks through the medial and lateral ventroposterior (vpm and vpl), ventrolateral (vl), reticular (nrt), and posterior (po) thalamic nuclei. single units were classified according to their: 1) location within the nuclei, 2) receptive fields, and 3) response to standar ... | 1990 | 2322860 |
| mapping the effects of motor cortex stimulation on somatosensory relay neurons in the rat thalamus: direct responses and afferent modulation. | single unit recordings were used to map the spatial distribution of motor (mi) cortical influences on thalamic somatosensory relay nuclei in the rat. a total of 215 microelectrode penetrations were made to record single neurons in tracks through the medial and lateral ventroposterior (vpm and vpl), ventrolateral (vl), reticular (nrt), and posterior (po) thalamic nuclei. single units were classified according to their: 1) location within the nuclei, 2) receptive fields, and 3) response to standar ... | 1990 | 2322860 |
| aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. | aminooxy analogues of spermidine, 1-aminooxy-3-n-[3-aminopropyl]- aminopropane (ap-apa) and n-[2-aminooxyethyl]-1,4-diaminobutane (aoe-pu), were tested as substrates or inhibitors of the enzymes involved in methionine and polyamine metabolism. both compounds were good competitive inhibitors and poor substrates of spermine synthase, good substrates of cytosolic polyamine acetyltransferase, inactivators of s-adenosylmethionine decarboxylase and inhibitors of ornithine decarboxylase. ap-apa and aoe ... | 1990 | 2292587 |
| prolongation of anesthesia with xylazine, ketamine, and guaifenesin in horses: 64 cases (1986-1989). | on 74 occasions, 54 horses and 6 foals were anesthetized with xylazine and ketamine or xylazine, guaifenesin, and ketamine, with or without butorphanol. on 64 occasions, anesthesia was prolonged for up to 70 minutes (34 +/- 15 min) by administration of 1 to 9 supplemental iv injections of xylazine and ketamine at approximately a third the initial dosage. all horses except 5 were positioned in lateral recumbency, and oxygen was insufflated. in adult horses, the time from induction of anesthesia t ... | 2008 | 2276967 |
| the aps knee joint prosthesis. a review of 32 patients. | first clinical and radiographic results with a new knee joint prosthesis, implanted without cement, are reported and the characteristics of the implant (dowel fixation and special instrumentation) presented. the first series of 35 joints with a follow-up period of 1-3 years shows excellent results. radiographically, primary osseous integration cannot be positively identified in all cases, but it could be proved in most instances. cement-free implantation requires good preoperative bone quality a ... | 2008 | 2271356 |
| cloning and sequence analysis of mink growth hormone cdna. | a cdna clone for mink growth hormone (gh) was isolated from a mink pituitary cdna library, employing a part of rat growth hormone cdna sequence as a probe. according to the nucleotide sequence, mature mink gh consists of 190 amino acids with a calculated molecular weight of 21,720. the amino acid sequence homology between the mature region of mink gh and those of pig gh, rat gh, bovine gh and human gh was 98.4%, 93.7%, 89.0% and 66.7%, respectively. | 1990 | 2268323 |
| [pregnancy and cystic fibrosis. a case history]. | the authors report a case of pregnancy in a patient suffering from moderately severe cystic fibrosis (the syndrome consisted of diffused obstruction in respiratory function with a vital capacity of 79% and the lowered blood oxygen level with arterial blood gas estimations; oxygen saturation was 94%). the condition was marked by temporary worsening during the pregnancy in which infective bronchitis supervened). she also threatened to go into early labour and did in fact deliver at 36 1/2 weeks of ... | 2007 | 2258595 |
| chlamydial igg and iga in serum and follicular fluid among patients undergoing in vitro fertilisation. | the point prevalence of igg and iga antibodies to chlamydia was analyzed in serum and follicular fluid in 63 patients undergoing in vitro fertilisation (ivf) in comparison to sera of 298 healthy women by the single serovar (l2) inclusion immunoperoxidase assay (ipa). the presence of specific igg and iga to chlamydia in follicular fluid was demonstrated. no statistical association was found between the presence of specific chlamydia igg and iga in serum and follicular fluid to oocyte fertilizatio ... | 1990 | 2242796 |
| desferrioxamine provocative test: methodology for estimating iron and total iron binding capacity. | 2006 | 2242435 | |
| probing the coenzyme specificity of glyceraldehyde-3-phosphate dehydrogenases by site-directed mutagenesis. | by combining our knowledge of the crystal structure of the glycolytic nad-dependent glyceraldehyde-3-phosphate dehydrogenase (gapdh) and the sequence of the photosynthetic nadp-dependent gapdh of the chloroplast, two particular amino acid residues were predicted as the principal determinants of differing coenzyme specificity. by use of site-directed mutagenesis, the amino acids leu 187 and pro 188 of gapdh from bacillus stearothermophilus have been replaced with ala 187 and ser 188, which occur ... | 1990 | 2223764 |
| probing the coenzyme specificity of glyceraldehyde-3-phosphate dehydrogenases by site-directed mutagenesis. | by combining our knowledge of the crystal structure of the glycolytic nad-dependent glyceraldehyde-3-phosphate dehydrogenase (gapdh) and the sequence of the photosynthetic nadp-dependent gapdh of the chloroplast, two particular amino acid residues were predicted as the principal determinants of differing coenzyme specificity. by use of site-directed mutagenesis, the amino acids leu 187 and pro 188 of gapdh from bacillus stearothermophilus have been replaced with ala 187 and ser 188, which occur ... | 1990 | 2223764 |
| mucinous ascites associated with rupture of benign ovarian teratoma. case report. | 2007 | 2223689 | |
| mucinous ascites associated with rupture of benign ovarian teratoma. case report. | 2007 | 2223689 | |
| [biochemistry of mitochondrial encephalomyopathy]. | 2007 | 2223265 | |
| [biochemistry of mitochondrial encephalomyopathy]. | 2007 | 2223265 | |
| [a case illustrating diagnostic difficulties in bronchiolo- alveolar cancer]. | 2007 | 2168044 | |
| [familial juvenile nephronophthisis]. | 2007 | 2075033 | |
| [fractures-dislocations of the shoulder in middle-aged and elderly patients]. | 114 patients with fracture dislocations of the proximal end of humerus have been treated and observed. 83 of them were subjected to conservative and 31--to surgical treatment. clinical, roentgenologic and radiologic evaluation of the immediate and long-term results allowed to formulate recommendations as to the selection of the treatment method of humerus fracture dislocations depending upon their type and general state of the patients. | 2007 | 2074957 |
| no evidence for the enhanced production of insulin autoantibodies after confrontation with common viral antigens in insulin dependent diabetes mellitus. | the production of insulin autoantibodies (iaa) was studied after common viral infections in 12 children with type 1 diabetes mellitus and in their 18 healthy siblings. in addition, the production of iaa was measured after influenza vaccination with booster in 39 patients with type 1 diabetes mellitus and in 39 healthy controls. in 7 of the 12 diabetic children 13 viral infections were serologically confirmed. among the siblings 14 periods of infection were noted in 9 individuals. a significant r ... | 2007 | 2074915 |
| oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. role of scavenger receptor and endothelium-derived nitric oxide. | we studied the effects of low density lipoprotein (ldl) on endothelium function. | 1991 | 2040054 |
| violent trends. | 2007 | 2034554 | |
| hospital outbreak of scabies stemming from two aids patients with norwegian scabies. | 2007 | 1971073 | |
| use of dna probes in the study of silage colonization by lactobacillus and pediococcus strains. | a technique to monitor lactic acid bacteria inoculants in silage, based on specific dna probes, was developed and used to evaluate the colonization properties of two strains of lactobacillus plantarum and one strain of pediococcus pentosaceus which were used as maize silage inoculants in farm conditions. the results indicated that these three strains were able to dominate the natural microflora of the silage, representing more than the 95% of the bacterial biomass of the maize silage. these stud ... | 1991 | 1960106 |
| the effect of prophylaxis with chloroquine and proguanil on delayed-type hypersensitivity and antibody production following vaccination with diphtheria, tetanus, polio, and pneumococcal vaccines. | in vitro studies have shown that anti-malarial drugs suppress immunity. in this study, the effects of chloroquine and proguanil (paludrine) on the cellular and humoral immune system were measured by two in vivo methods: 1) cell-mediated immunity (delayed cutaneous hypersensitivity) i.e., skin tests with seven delayed-type common antigens (multitest) and 2) humoral immunity by measurement of specific antibody response to vaccination. sixty healthy young individuals were randomized into four group ... | 1991 | 1951872 |
| isolated significant left main coronary artery stenosis: angiographic, hemodynamic, and clinical findings in 16 patients. | among 21,545 adult patients who underwent consecutive coronary angiography, 16 (0.07%) were found during their coronary arteriography to have a significant isolated stenotic lesion (luminal diameter narrowing of 50% or more) located at the left main coronary artery. the remaining major epicardial coronary arteries and their branches were free of disease. a strong predilection for the isolated lesion to occur at the ostium of the left main artery was found (12 patients). the most common presentin ... | 2007 | 1950993 |
| [leukocyte and atherosclerosis]. | 2007 | 1947989 | |
| acid and the pain of non-ulcer dyspepsia. | 2007 | 1932675 | |
| new prosthetic venous collar anastomotic technique: combining the best of other procedures. | 2007 | 1913097 | |
| the occurrence and growth of microorganisms during the fermentation of fish sausage. | minced fish (mullet) sausage mixes containing added sugar, salt, nitrate, nitrite and spices were fermented (48 h, 30 degrees c) by indigenous flora or by a starter culture (pediococcus acidilactici) and the microbial ecology and behaviour of various bacteria was monitored. pediococcus pentosaceus and lactobacillus plantarum dominated the indigenous fermentation, achieving populations of 10(7)-10(8) cfu/g by 48 h, and decreasing the ph of the mix to 4.5-4.7. significant growth (10(5)-10(7) cfu/g ... | 1991 | 1909546 |
| the effect of pediococcus damnosus and pediococcus pentosaceus on the growth of pathogens in minced meat. | the antibacterial effects of one strain of pediococcus damnosus and two strains of pediococcus pentosacaeus against clostridium perfringens, listeria monocytogenes, salmonella infantis and yersinia enterocolitica were investigated. growth inhibition studies were conducted in juice from minced meat incubated at +6 degrees c and +15 degrees c for various periods after the inoculation with pediococci. inhibitory effects were seen for all bacteria tested. | 1991 | 1907475 |
| cyclophellitol: a naturally occurring mechanism-based inactivator of beta-glucosidases. | the natural product cyclophellitol, isolated from the culture filtrate of a mushroom, phellinus sp. is found to be a highly specific and effective irreversible inactivator of beta-glucosidases. it inactivates the beta-glucosidases from both almond emulsin and agrobacter sp. according to pseudo-first order kinetics with inactivation constants of ki = 0.34 mm, ki = 2.38 min-1, and ki = 0.055 mm, ki = 1.26 min-1 respectively. no reactivation of the inactivated enzyme is seen upon dialysis, thus pro ... | 1991 | 1904221 |
| [3h]mk-801 binding to n-methyl-d-aspartate receptors solubilized from rat brain: effects of glycine site ligands, polyamines, ifenprodil, and desipramine. | the n-methyl-d-aspartate (nmda) receptor is thought to contain several distinct binding sites that can regulate channel opening. in the present experiments, the effects of ligands for these sites have been examined on [3h]mk-801 binding to a soluble receptor preparation, which had been passed down a gel filtration column to reduce the levels of endogenous small-molecular-weight substances. glycine site agonists, partial agonists, and antagonists gave effects similar to those observed in membrane ... | 1991 | 1828832 |
| regulation and glucocorticoid-independent induction of lipocortin i in cultured astrocytes. | stimulation of prostaglandin (pg) release in rat astroglial cultures by various substances, including phorbol esters, melittin, or extracellular atp, has been reported recently. it is shown here that glucocorticoids (gcs) reduced both basal and stimulated pgd2 release. hydrocortisone, however, did not inhibit atp-, calcium ionophore a23187-, or tetradecanoyl phorbol acetate (tpa)-stimulated arachidonic acid release, and only tpa stimulations were affected by dexamethasone. gc-mediated inhibition ... | 1991 | 1828830 |
| topical puva therapy for vitiligo. | vitiligo, a pigmentary disorder of the skin, causes the appearance of white patches which are profoundly devastating to the person afflicted with this disease. this article outlines the safe use of topical puva therapy in the office for treating those patients with less than 20% skin surface involvement. this treatment has a response rate of approximately 50%. | 2006 | 1828681 |
| topical puva therapy for vitiligo. | vitiligo, a pigmentary disorder of the skin, causes the appearance of white patches which are profoundly devastating to the person afflicted with this disease. this article outlines the safe use of topical puva therapy in the office for treating those patients with less than 20% skin surface involvement. this treatment has a response rate of approximately 50%. | 2006 | 1828681 |
| cost, controversy, crisis: low back pain and the health of the public. | 2006 | 1828670 | |
| overproduction of glutamate racemase of pediococcus pentosaceus in escherichia coli clone cells and its purification. | we previously isolated a 6.0-kb dna fragment that specifies glutamate racemase activity from the chromosomal dna of pediococcus pentosaceus by digestion with hindiii (n. nakajima, k. tanizawa, h. tanaka, and k. soda, 1986), agric. biol. chem. 50, 2823-2830). we digested it further with ecori to obtain a fragment of 1.8 kb, which was blunt-ended and ligated into the smai site of vector plasmid pkk223-3. the recombinant plasmid showed a high glutamate racemase activity upon transformation of esche ... | 1991 | 1821778 |
| successful introduction of an intravenous line insertion team at a municipal hospital. | an intravenous line insertion and blood drawing team was introduced as a pilot project in a large municipal hospital in the new york city. the program successfully accomplished the goals of reducing house staff workload, improving house staff morale and patient care, and increasing available time for house staff education. | 2006 | 1800767 |
| successful introduction of an intravenous line insertion team at a municipal hospital. | an intravenous line insertion and blood drawing team was introduced as a pilot project in a large municipal hospital in the new york city. the program successfully accomplished the goals of reducing house staff workload, improving house staff morale and patient care, and increasing available time for house staff education. | 2006 | 1800767 |
| moderate and mild mental retardation in the martin-bell syndrome. | a survey of children attending schools for the moderately or the mildly mentally handicapped has shown that two out of 25 boys and two out of 22 girls with idiopathic moderate mental retardation had the martin-bell syndrome, while none of 75 boys and one out of 51 girls with mild mental retardation were fraxa positive. consideration of these figures along with published studies suggests that 7% of moderate and 3.8% of mild idiopathic mental retardation in boys, and 2.5% of moderate and 3.3% of m ... | 2006 | 1800751 |
| moderate and mild mental retardation in the martin-bell syndrome. | a survey of children attending schools for the moderately or the mildly mentally handicapped has shown that two out of 25 boys and two out of 22 girls with idiopathic moderate mental retardation had the martin-bell syndrome, while none of 75 boys and one out of 51 girls with mild mental retardation were fraxa positive. consideration of these figures along with published studies suggests that 7% of moderate and 3.8% of mild idiopathic mental retardation in boys, and 2.5% of moderate and 3.3% of m ... | 2006 | 1800751 |
| thoracic actinomycosis--review of 9 cases. | nine cases of thoracic actinomycosis treated in the period from 1976 to 1990 were reviewed. among them, 4 cases were children. the clinical symptoms and laboratory examinations were non-specific. chest roentgenographic manifestations including nodular (3 cases), infiltrations (4 cases), and infiltrations with pleural changes (2 cases) were also non-specific. chest wall masses were noted in four patients. there were no cases correctly diagnosed on admission. the diagnosis of thoracic actinomycosi ... | 2006 | 1797368 |
| thoracic actinomycosis--review of 9 cases. | nine cases of thoracic actinomycosis treated in the period from 1976 to 1990 were reviewed. among them, 4 cases were children. the clinical symptoms and laboratory examinations were non-specific. chest roentgenographic manifestations including nodular (3 cases), infiltrations (4 cases), and infiltrations with pleural changes (2 cases) were also non-specific. chest wall masses were noted in four patients. there were no cases correctly diagnosed on admission. the diagnosis of thoracic actinomycosi ... | 2006 | 1797368 |