Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| inhibition of hepatitis e virus replication by peptide-conjugated morpholino oligomers. | hepatitis e virus (hev) infection is a cause of hepatitis in humans worldwide and has been associated with a case-fatality rate of up to 30% in pregnant women. recently, persistent and chronic hev infections have been recognized as a serious clinical problem, especially in immunocompromised individuals. to date, there are no fda-approved hev-specific antiviral drugs. in this study, we evaluated antisense peptide-conjugated morpholino oligomers (ppmo) designed against hev genomic sequences as pot ... | 2015 | 26086884 |
| a comprehensive study of neutralizing antigenic sites on the hepatitis e virus (hev) capsid by constructing, clustering, and characterizing a tool box. | the hepatitis e virus (hev) orf2 encodes a single structural capsid protein. the e2s domain (amino acids 459-606) of the capsid protein has been identified as the major immune target. all identified neutralizing epitopes are located on this domain; however, a comprehensive characterization of antigenic sites on the domain is lacking due to its high degree of conformation dependence. here, we used the statistical software spss to analyze celisa (competitive elisa) data to classify monoclonal anti ... | 2015 | 26085097 |
| seroprevalence for hepatitis e and other viral hepatitides among diverse populations, malawi. | data on prevalence of hepatitis e virus (hev) in malawi is limited. we tested blood samples from hiv-uninfected and -infected populations of women and men enrolled in research studies in malawi during 1989-2008 to determine the seroprevalence of hev, hepatitis a virus (hav), hepatitis b virus (hbv), and hepatitis c virus (hcv). samples were tested for igg against hev, total antibodies against hav and hcv, and presence of hbv surface antigens. of 800 samples tested, 16.5% were positive for hev ig ... | 2015 | 26079666 |
| wildlife reservoir for hepatitis e virus, southwestern france. | pigs are a reservoir for hepatitis e virus (hev). to determine the relative contribution of game to the risk for human hev infection in southwestern france, we tested wildlife samples. hev rna was in 3.3% of wildlife livers, indicating that in this region, eating game meat is as risky as eating pork. | 0 | 26079541 |
| detection of hepatitis e virus antibodies in dogs in the united kingdom. | hepatitis e virus (hev) genotypes 3 and 4 are zoonotic pathogens, with pigs predominantly implicated in disease transmission. the rapid rise in human cases in developed countries over the past decade indicates a change in epidemiology of hev, and it has been suggested that additional animal species may be involved in transmission of infection. multiple studies have identified contact with dogs as a risk factor for hev infection in industrialised nations, and a low seroprevalence to hev has previ ... | 2015 | 26076364 |
| activation of cxcl-8 transcription by hepatitis e virus orf-1 via ap-1. | hepatitis e virus (hev) is a small nonenveloped single-stranded positive-sense rna virus and is one of the major causes for acute hepatitis worldwide. cxcl-8 is a small multifunctional proinflammatory chemokine. it was reported recently that hev infection significantly upregulates cxcl-8 gene expression. in this study, we investigated the mechanism of hev-induced cxcl-8 transcriptional activation. using cxcl-8 promoter reporters of different lengths ranging from -1400 to -173, we showed that -17 ... | 2015 | 26074679 |
| therapeutic targets for the treatment of hepatitis e virus infection. | hepatitis e virus (hev) is one of the most common causes of acute viral hepatitis in the world with an estimated 20 million infections per year. although the mortality rate is < 1% among the general population, pregnant women can have a fatality rate of up to 30%. additionally, chronic hepatitis e has increasingly become a significant clinical problem in immunocompromised individuals. effective antivirals against hev are needed. | 2015 | 26073772 |
| dysgeusia in a patient with guillain-barré syndrome associated with acute hepatitis e: a case report and literature review. | guillain-barré syndrome (gbs) is usually triggered by viral or bacterial infection. in addition, it was recently reported that infection with hepatitis e virus (hev) also causes gbs. a 49-year-old man presented with acute-onset paralysis in all extremities and dysgeusia during an episode of acute hepatitis. serological tests showed the presence of anti-hev igm antibodies and hev-rna in the serum. as an electrophysiological examination showed acute demyelinating polyradiculoneuropathy, the patien ... | 2015 | 26073247 |
| a novel linear neutralizing epitope of hepatitis e virus. | hepatitis e virus (hev) is a serious public health problem that causes acute hepatitis in humans and is primarily transmitted through fecal and oral routes. the major anti-hev antibody responses are against conformational epitopes located in a.a. 459-606 of hev porf2. all reported neutralization epitopes are present on the dimer domain constructed by this peptide. while looking for a neutralizing monoclonal antibody (mab)-recognized linear epitope, we found a novel neutralizing linear epitope (l ... | 2015 | 26051517 |
| frequency and prognosis of acute pancreatitis associated with acute hepatitis e: a systematic review. | the association of acute pancreatitis (ap) with viral hepatitis is well known, and is usually attributed to hav, hbv, or hcv. ap related to acute hepatitis e (ahe) has been rarely described, and the typical profile is that of a young male, residing in an endemic area, presenting with mild to moderate pancreatitis, and improving with conservative management. | 2015 | 26049260 |
| hepatitis e virus chronic infection of swine co-infected with porcine reproductive and respiratory syndrome virus. | in developed countries, most of hepatitis e human cases are of zoonotic origin. swine is a major hepatitis e virus (hev) reservoir and foodborne transmissions after pork product consumption have been described. the risk for hev-containing pig livers at slaughter time is related to the age at infection and to the virus shedding duration. porcine reproductive and respiratory syndrome virus (prrsv) is a virus that impairs the immune response; it is highly prevalent in pig production areas and suspe ... | 2015 | 26048774 |
| evidence of viral dissemination and seasonality in a mediterranean river catchment: implications for water pollution management. | conventional wastewater treatment does not completely remove and/or inactive viruses; consequently, viruses excreted by the population can be detected in the environment. this study was undertaken to investigate the distribution and seasonality of human viruses and faecal indicator bacteria (fib) in a river catchment located in a typical mediterranean climate region and to discuss future trends in relation to climate change. sample matrices included river water, untreated and treated wastewater ... | 2015 | 26046988 |
| pathobiology of hepatitis e: lessons learned from primate models. | like the other hepatitis viruses, hepatitis e virus (hev) has been difficult to study because of limitations in cell culture systems and small animal models. much of what we know has come from epidemiological studies in developing countries and, more recently, in industrialized countries. however, the epidemiology is very different in these two settings: hepatitis e in developing countries is epidemic as well as sporadic, principally water-borne, most likely to cause disease in older children an ... | 2013 | 26038457 |
| molecular biology and replication of hepatitis e virus. | hepatitis e virus (hev), a single-stranded, positive-sense rna virus, is responsible for acute hepatitis e epidemics in many developing countries, and the virus is also endemic in some industrialized countries. hepatitis e is a recognized zoonotic disease, and several animal species, including pigs, are potential reservoirs for hev. the genome of hev contains three open reading frames (orfs). orf1 encodes the nonstructural proteins, orf2 encodes the capsid protein, and orf3 encodes a small multi ... | 2012 | 26038426 |
| investigating the origin and global dispersal history of hepatitis e virus genotype 4 using phylogeographical analysis. | hepatitis e virus (hev) genotype 4 has mainly been isolated from sporadic hepatitis cases and swine in asian countries. we analysed the origin and global dispersal history of genotype 4 using a bayesian phylogeographical approach. | 2016 | 26037061 |
| unusual serological response to hepatitis e virus in plasma donors consistent with re-infection. | hepatitis e virus (hev)-positive plasma donations, identified by a plasma mini-pool screening approach, were analysed using serological methods for the presence of anti-hev igm and igg. avidity testing was performed on the igg-reactive donations. anti-hev igg with high avidity was observed in two donors together with high viral loads, but with the absence of anti-hev igm. these data are suggestive of re-infection in a small proportion of plasma donors, which has not previously been reported. | 2015 | 26031310 |
| viral and antibody prevalence of hepatitis e in european wild boars (sus scrofa) and hunters at zoonotic risk in the latium region. | hepatitis e virus (hev) is a member of the genus hepevirus within the family hepeviridae. hepatitis e is recognized as a zoonosis, and swine and wild boars (sus scrofa) are known reservoirs of hev infection. the aim of this study was to investigate the presence of hev in wild boars and hunters exposed to infection in central italy (latium region). during the hunting season, blood samples were collected from 228 wild boars and 20 hunters. the seroprevalence of hev infection was determined using a ... | 2015 | 26025105 |
| comparable quality attributes of hepatitis e vaccine antigen with and without adjuvant adsorption-dissolution treatment. | most vaccines require adjuvants for antigen stabilization and immune potentiation. aluminum-based adjuvants are the most widely used adjuvants for human vaccines. previous reports demonstrated the preservation of antigen conformation and other antigen characteristics after recovery from adjuvanted hepatitis b and human papillomavirus vaccines. in this study, we used a combination of various physiochemical and immunochemical methods to analyze hepatitis e vaccine antigen quality attributes after ... | 2015 | 26018442 |
| [prevalence of hepatitis e markers in children]. | frequency of detection determination for past and current hepatitis e virus (hev) infection markers in children with immune suppression, as well as children with normal immune status. | 2015 | 26016342 |
| retraction. rna transcripts of full-length cdna clones of rabbit hepatitis e virus are infectious in rabbits. | 2015 | 26015321 | |
| [evaluation of viral hepatitis in solid organ transplantation]. | renal transplantation has significantly improved survival of patients with end-stage renal disease (esrd). transplantation is the best treatment in this population of patients. despite the introduction of various preventive measures, viral hepatitis, i.e. hepatitis b virus (hbv) and hepatitis c virus (hcv) infections, are still a major problem because they are common in patients on renal replacement therapy as well as in allograft recipients. they are a significant cause of morbidity and mortali ... | 2014 | 26012153 |
| hepatitis e virus genotype 3 diversity: phylogenetic analysis and presence of subtype 3b in wild boar in europe. | an increasing number of indigenous cases of hepatitis e caused by genotype 3 viruses (hev-3) have been diagnosed all around the word, particularly in industrialized countries. hepatitis e is a zoonotic disease and accumulating evidence indicates that domestic pigs and wild boars are the main reservoirs of hev-3. a detailed analysis of hev-3 subtypes could help to determine the interplay of human activity, the role of animals as reservoirs and cross species transmission. although complete genome ... | 2015 | 26008708 |
| molecular investigation on the presence of hepatitis e virus (hev) in wild game in north-western italy. | meat products from hev-infected reservoir animal species are capable of transmitting hev to humans and represent a public health concern. human hev cases have been linked to the consumption of raw or undercooked pig liver sausages, pork, and game meats, such as wild boars and deer worldwide. direct exposure to swine or wild game species might also represent a source of hev transmission especially for veterinarians, hunters, or butchers. a limited amount of data is available on hev prevalence in ... | 2015 | 26006251 |
| detection of emerging and re-emerging pathogens in surface waters close to an urban area. | current knowledge about the spread of pathogens in aquatic environments is scarce probably because bacteria, viruses, algae and their toxins tend to occur at low concentrations in water, making them very difficult to measure directly. the purpose of this study was the development and validation of tools to detect pathogens in freshwater systems close to an urban area. in order to evaluate anthropogenic impacts on water microbiological quality, a phylogenetic microarray was developed in the conte ... | 2015 | 26006125 |
| a 1-year quantitative survey of noro-, adeno-, human boca-, and hepatitis e viruses in raw and secondarily treated sewage from two plants in norway. | a study of enteric viruses in raw and treated sewage from two secondary treatment plants, which received sewage from oslo city (plant a) and small municipalities in hedmark county in norway (plant b), showed high levels of noro-, adeno-, and bocavirus throughout the year. a seasonal variation was observed for adeno- and gii norovirus with higher levels during winter and bocavirus that had more positive samples during winter. the virus concentrations in raw sewage were comparable in the two plant ... | 2015 | 26003323 |
| [the establishment of high-throughput neutralization titer evaluation model for hepatitis e virus (hev)]. | the lack of effective in vitro infection model for hepatitis e virus (hev) has greatly hindered the quantitative analysis of neutralizing titers of anti-hev antibodies and human sera, thus impeding further studies of hev-stimulated antibody responses and the immunological mechanisms. in order to improve this situation, the infection of hepg2 cells that are inefficient for hev replication was continuously monitored until the viral load reached the limit of detection on day 13, the results of whic ... | 2015 | 25997322 |
| notes from the field: hepatitis e outbreak among refugees from south sudan - gambella, ethiopia, april 2014-january 2015. | in early april 2014, two south sudanese refugees in the gambella region of western ethiopia experienced acute onset of jaundice, accompanied by fever. one patient was a pregnant woman aged 24 years evaluated at a routine prenatal clinic visit in leitchour refugee camp. the second patient was a malnourished boy aged 1 year who resided in tierkidi refugee camp. the boy died despite hospitalization. during the last 2 weeks of may, four more cases of acute jaundice syndrome (ajs), defined as yellow ... | 2015 | 25996097 |
| dengue and hepatitis e virus infection in pregnant women in eastern sudan, a challenge for diagnosis in an endemic area. | dengue fever and hepatitis e virus infection are both a public health problem in developing countries due to poor sanitation. infection with viral hepatitis and dengue fever can present with similar clinical such and fever, headache and abortion. this study was conducted in port-sudan city in the eastern part of the country. elisa and real time pcr tests were used to detect the infection. a total number of 39 pregnant women with a mean age 26 ±7.8 were included in the study. all of them had feve ... | 2014 | 25995787 |
| hepatitis e virus co-infection in hiv-infected patients in foggia and naples in southern italy. | hepatitis e virus (hev) infection represents an emerging infection in developed countries and is thought to be a zoonotic infection. it has recently been described as a new causative agent of acute and chronic hepatitis in immunosuppressed subjects, including hiv-infected patients. the aim of this study was to assess the sero-virological prevalence of hev in hiv patients and in the general population as control group. | 2015 | 25994453 |
| seroprevalence in blood donors reveals widespread, multi-source exposure to hepatitis e virus, southern france, october 2011. | the apparent seroprevalence of hepatitis e virus (hev)varies greatly among developed countries depending on the geographical area and the sensitivity of immunoassays. we used a validated assay to determine the prevalence of hev igg and igm antibodies among 3,353 blood donors living in southern france,who gave blood during the two first weeks of october 2011 and participated in the study. demographic and epidemiological information was collected using aspecific questionnaire. we also screened 591 ... | 2015 | 25990359 |
| survival and elimination of hepatitis e virus: a review. | recently, foodborne transmission of hepatitis e virus (hev) has become a concern due to the identification of undercooked pork products as a risk factor for infection. the limited number of studies which have been performed indicate that hev could remain infectious at temperatures used in some cooking regimes, although inactivation by heating at 71 °c for 20 min has been demonstrated. there are significant gaps in our knowledge regarding the survival of hev in foods and the environment (includin ... | 2015 | 25989918 |
| seroprevalence of hepatitis e virus infection in the irish pig population. | hepatitis e is an acute viral disease of humans, occurring in explosive outbreaks in the developing world and as sporadic cases in returning travellers. increasing recognition of indigenous transmission in western countries suggests a zoonotic source of infection, most likely pigs. to determine if hepatitis e virus is present in irish pigs, sera from 330 animals were examined for antibodies using a commercially available elisa. | 2015 | 25977752 |
| epidemiology of domestically acquired hepatitis e virus infection in japan: assessment of the nationally reported surveillance data, 2007-2013. | in recent years, there has been an increase in the number of reported hepatitis e virus (hev) infections from developed countries. to describe recent trends in notification and potential risk groups and risk factors in japan, hev infection cases and demographic, food consumption, clinical and laboratory data reported during 2007-2013 were analysed. in total, 530 hev infections were reported during 2007-2013. amongst 462 domestic cases, the mean age was 56.5 years (sd 13.9) and 80.1 % were male. ... | 2015 | 25976003 |
| [cloning and expression and preliminary antigenicity identification for the diagnostic antigen of hepatitis e virus]. | to clone, express and purify thioredoxin (named as n5), a specific diagnostic antigen of hepatitis e virus (hev), and to initially evaluate its antigenicity and serological test performance. | 2015 | 25975408 |
| cultural drivers and health-seeking behaviours that impact on the transmission of pig-associated zoonoses in lao people's democratic republic. | pig rearing is an important income source in the lao people's democratic republic (pdr), with many smallholder farmers using traditional free-range pig production systems. despite the potentially significant health risks posed by pig production regarding pig-associated zoonoses, information on the sociocultural drivers of these zoonoses is significantly lacking. this review summarises the existing sociocultural knowledge on eight pig-associated zoonoses suspected to be endemic in southeast asia: ... | 2015 | 25973203 |
| association of hepatitis e virus and essential cryoglobulinemia? | 2015 | 25959152 | |
| comparative sensitivity of commercial tests for hepatitis e genotype 3 virus antibody detection. | hepatitis e virus (hev) acute infection is often diagnosed only by anti-hev igm elisa methods, whose sensitivity varies, according to different reports. reports assessing the specificity of commercial assays for anti-hev igg testing are scarce, and estimates of sensitivity and specificity are both controversial. the aim of this work is to assess the sensitivity of different commercial techniques for hev genotype 3 antibody (anti-hev) igm and igg detection in entirely specific sample panels inclu ... | 2015 | 25959136 |
| virus safety of islet cell transplantation from transgenic pigs to marmosets. | transplantation of pig islet cells for the treatment of diabetes may be a more effective approach compared with the application of insulin. however, before introduction into the clinic, efficacy and safety of this treatment have to be shown. non-human primate models may be used for this, despite the fact that they are characterised by several limitations. here we investigate the prevalence of porcine endogenous retroviruses (pervs), which are present in the genome of all pigs and which may infec ... | 2015 | 25956348 |
| a review of the current status of relevant zoonotic pathogens in wild swine (sus scrofa) populations: changes modulating the risk of transmission to humans. | many wild swine populations in different parts of the world have experienced an unprecedented demographic explosion that may result in increased exposure of humans to wild swine zoonotic pathogens. interactions between humans and wild swine leading to pathogen transmission could come from different ways, being hunters and game professionals the most exposed to acquiring infections from wild swine. however, increasing human settlements in semi-natural areas, outdoor activities, socio-economic cha ... | 2017 | 25953392 |
| presence of pathogenic enteric viruses in illegally imported meat and meat products to eu by international air travelers. | one hundred twenty two meat samples confiscated from passengers on flights from non-european countries at the international airport of bilbao (spain) were tested for the presence of the main foodborne viral pathogens (human noroviruses genogroups i and ii, hepatitis a and e viruses) during 2012 and 2013. a sample process control virus, murine norovirus, was used to evaluate the correct performance of the method. overall, 67 samples were positive for at least one enteric viruses, 65 being positiv ... | 2015 | 25951793 |
| first report of hepatitis e virus infection in sika deer in china. | hepatitis e virus (hev), a single stranded rna, nonenveloped virus, belongs to the genus hepevirus, in the family of hepeviridae. in this study, 46 (5.43%) out of the 847 serum samples from sika deer (cervus nippon) were detected as seropositive with hepatitis e virus (hev) by enzyme linked immunosorbent assay (elisa). these samples were collected from inner mongolia and jilin and heilongjiang provinces in china, between october 2012 and october 2013. seroprevalence of hev infection in male and ... | 2015 | 25949999 |
| seroprevalence and risk factors of hepatitis e virus infection among children in china. | hepatitis e virus (hev) infection is an important public health concern worldwide, especially in developing countries, causing waterborne outbreaks as well as sporadic autochthonous hepatitis. china is usually considered to be a hev-endemic area, but the prevalence of hev infection in children in mainland china remains unclear. between may 2013 and july 2014, a cross-sectional study was conducted to estimate the seroprevalence and potential risk factors associated with the acquisition of hev inf ... | 2015 | 25940435 |
| [development and assessment of a chemiluminescence assay kit for detecting anti-hev igg]. | to develop an anti-hepatitis e virus (anti-hev) igg chemiluminescence assay kit and assess its clinical application. | 2015 | 25940294 |
| enhanced humoral response in pregnant mice immunized with liposome encapsulated recombinant neutralizing epitope protein of hepatitis- e virus. | pregnant women from developing countries are at high-risk of hepatitis e-associated high mortality and constitute priority population for vaccination. so far, candidate vaccines have not been evaluated during pregnancy. we evaluated our vaccine candidate, recombinant neutralizing epitope protein (rnep) encapsulated in liposomes, in pregnant mice. | 2015 | 25935713 |
| generation of hepatitis e virus-like particles of two new genotypes g5 and g6 and comparison of antigenic properties with those of known genotypes. | in addition to the four major genotypes (g1 through g4) known for human hepatitis e virus (hev), two new genotypes (g5 and g6) were suggested, based on unique viral nucleotide sequences derived from wild boars in japan. it has been unknown whether the virus of these new genotypes can cause hepatitis in humans; neither g5 nor g6 hev has been found in patients to date. to study the antigenic properties of g5 and g6 hev, we expressed n-terminus-truncated hev orf2 protein by a recombinant baculoviru ... | 2015 | 25934534 |
| swine is a possible source of hepatitis e virus infection by comparative study of hepatitis a and e seroprevalence in thailand. | hepatitis a virus (hav) and hepatitis e virus (hev) infection in developing countries are associated with contaminated food or water. although thailand is non-endemic for hev, sporadic infections may occur from zoonotic transmission. individuals between 7 months to 69 years (mean age = 32.8) from predominantly islamic narathiwat (n = 305) and swine farm-dense lop buri (n = 416) provinces were screened for anti-hev and anti-hav antibodies by commercial enzyme-linked immunosorbent assay and automa ... | 2015 | 25927925 |
| monkeys and rats are not susceptible to ferret hepatitis e virus infection. | ferret hepatitis e virus (hev), a novel hepatitis e-like virus, has been identified in ferrets in the netherlands, japan, and the us. to determine whether ferret hev transmits to other animals, we inoculated laboratory rats (wistar), nude rats (long-evans-rnu/rnu), and cynomolgus monkeys with ferret hev (f4351) by intravenous injection. none of the animals demonstrated a positive sign for virus replication, indicating that rats and monkeys are not susceptible to ferret hev. | 2015 | 25925280 |
| the application of single strand conformation polymorphism (sscp) analysis in determining hepatitis e virus intra-host diversity. | genetic heterogeneity of rna populations influences virus pathogenesis, epidemiology and evolution. therefore, accurate information regarding virus genetic structure is highly important for both diagnostic and scientific purposes. for the hepatitis e virus (hev), the causal agent of hepatitis in humans, the intra-host population structure has been poorly investigated, mainly using the less sensitive rflp-based approach. the objective of this study was to assess the suitability and the accuracy o ... | 2015 | 25920567 |
| hepatitis e virus and related viruses in animals. | hepatitis e is an acute human liver disease in healthy individuals which may eventually become chronic. it is caused by the hepatitis e virus (hev) and can have a zoonotic origin. nearly 57,000 people die yearly from hepatitis e-related conditions. the disease is endemic in both developing and developed countries with distinct epidemiologic profiles. in developing countries, the disease is associated with inadequate water treatment, while in developed countries, transmission is associated with a ... | 2017 | 25919649 |
| analysis of complete genome sequences and a v239a substitution in the helicase domain of swine hepatitis e virus strains isolated in canada. | among canadian swine hev strains, only one complete genome sequence has been published so far, and there are no data on the virulence of these strains. a collection of 28 canadian swine hev strains was used in this study. after rna extraction, a portion of orf2, the 3' end of the helicase domain, and two complete genomes were amplified and sequenced. these two new canadian complete genomes belonged to two different subtypes and showed 87.5 and 87.7% sequence identity to the canadian swine hev st ... | 2015 | 25916609 |
| lessons from hepatitis e vaccine design. | acute hepatitis e is still a major public health issue, especially in developing countries, and hepatitis e virus (hev) infection will likely only be preventable through prophylactic vaccines. in this review, we describe the lessons learnt from developing the first commercial hepatitis e vaccine (hecolin), launched to market in china in 2012. the antigenicity and immunogenicity of vlp immunogens concomitant with the scalable escherichia coli system and our large-scale clinical verification resul ... | 2015 | 25913817 |
| hepatitis e virus infection as a possible cause of acute liver failure in europe. | in western countries, infection with the hepatitis e virus (hev) is considered to be rare and imported from endemic regions. however, the prevalence of hev infection has increased among adults in central europe. hev infection can cause acute liver failure (alf), but there have been only a few confirmed cases of hev-associated alf in europe. we investigated the number of cases of indeterminate alf associated with hev infection. | 2015 | 25912835 |
| high prevalence of hepatitis e virus in swedish moose--a phylogenetic characterization and comparison of the virus from different regions. | hepatitis e virus (hev) infects a range of species, including humans, pigs, wild boars and deer. zoonotic transmission may contribute to the high hev seroprevalence in the human population of many countries. a novel divergent hev from moose (alces alces) in sweden was recently identified by partial genome sequencing. since only one strain was found, its classification within the hev family, prevalence in moose and zoonotic potential was unclear. we therefore investigated samples from 231 moose i ... | 2015 | 25906163 |
| presence of hepatitis e virus in a red deer (cervus elaphus) population in central italy. | hepatitis e is an acute human disease caused by the hepatitis e virus (hev). in addition to humans, hev has been detected in several animal species and is recognized as a zoonotic pathogen. pigs, wild boar and deer can be reservoir. in this study, we evaluated hev prevalence in a free-living red deer (cervus elaphus) population in central italy by detecting virus-specific antibodies and rna in sera. a total of 35 of 251 red deer sera were positive for anti-hev igg. hev rna was detected in 10 of ... | 2017 | 25892400 |
| fatal disease associated with swine hepatitis e virus and porcine circovirus 2 co-infection in four weaned pigs in china. | in recent decades, porcine circovirus 2 (pcv2) infection has been recognized as the causative agent of postweaning multisystemic wasting syndrome, and has become a threat to the swine industry. hepatitis e virus (hev) is another high prevalent pathogen in swine in many regions of the world. pcv2 and hev are both highly prevalent in pig farms in china. | 2015 | 25889526 |
| evidence for the presence of autochthonous (locally acquired) cases of acute hepatitis e virus infections in italy since the 80s. | autochthonous (locally acquired) cases of acute hepatitis e virus have been recently reported in several developed countries. | 2015 | 25887055 |
| sequence analysis reveals a conserved extension in the capping enzyme of the alphavirus supergroup, and a homologous domain in nodaviruses. | members of the alphavirus supergroup include human pathogens such as chikungunya virus, hepatitis e virus and rubella virus. they encode a capping enzyme with methyltransferase-guanylyltransferase (mtase-gtase) activity, which is an attractive drug target owing to its unique mechanism. however, its experimental study has proven very difficult. | 2015 | 25886938 |
| enhanced mucosal immune responses induced by a combined candidate mucosal vaccine based on hepatitis a virus and hepatitis e virus structural proteins linked to tuftsin. | hepatitis a virus (hav) and hepatitis e virus (hev) are the most common causes of infectious hepatitis. these viruses are spread largely by the fecal-oral route and lead to clinically important disease in developing countries. to evaluate the potential of targeting hepatitis a and e infection simultaneously, a combined mucosal candidate vaccine was developed with the partial open reading frame 2 (orf2) sequence (aa 368-607) of hev (he-orf2) and partial virus protein 1 (vp1) sequence (aa 1-198) o ... | 2015 | 25875115 |
| the hepatitis e virus orf1 'x-domain' residues form a putative macrodomain protein/appr-1″-pase catalytic-site, critical for viral rna replication. | the hepatitis e virus (hev) orf1 gene encodes the non-structural polyprotein wherein the 'x-domain' still remains poorly defined. cellular x-domain associated macrodomain protein/adp-ribose-1″-monophosphatase (appr-1″-pase) activities are also reported in coronaviruses (cov), including identification of its homologs in alpha and rubella viruses. the present study investigated the role(s) of x-domain residues in hev replication cycle. in silico analysis showed a high degree of evolutionary conser ... | 2015 | 25870943 |
| hepatitis e virus detection in liver tissue from patients with suspected drug-induced liver injury. | hepatitis e virus (hev) infection is increasingly recognized as a cause of acute hepatitis in the industrialized world. we aimed to determine the frequency of acute hev infection in cases of suspected drug-induced liver injury (dili), mainly a diagnosis of exclusion. to this aim, formalin-fixed paraffin-embedded (ffpe) liver tissues of all cases routinely processed in our institute during a 2 1/2 years period in which dili was among the differential diagnoses (157 liver biopsies, 1 liver explant ... | 2015 | 25870858 |
| evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine kinase 1 with roc and logistic regression for hepatocellular carcinoma. | the purpose of this study was to evaluate the diagnostic efficiency for hepatocellular carcinoma (hcc) with the combined analysis of alpha-l-fucosidase (afu), alpha-fetoprotein (afp) and thymidine kinase 1 (tk1). serum levels of afu, afp and tk1 were measured in: 116 patients with hcc, 109 patients with benign hepatic diseases, and 104 normal subjects. the diagnostic value was analyzed using the logistic regression equation and receiver operating characteristic curves (roc). statistical distribu ... | 2015 | 25870783 |
| detection of hepatitis e virus genome in pig livers in antioquia, colombia. | hepatitis e is a form of endemic acute hepatitis found in humans in many countries worldwide and is caused by the hepatitis e virus (hev). detection of hev in pigs indicates that they may be carriers, possibly through zoonosis. the prevalence of hev in pigs in colombia is unknown. studies in the us found that 11% of pig livers sold in grocery stores are contaminated with hev. it is also known that hev can be inactivated when cooked, as it is labile to high temperatures. the aim of this study was ... | 2015 | 25867439 |
| outcome of hepatitis e virus infection in patients with inflammatory arthritides treated with immunosuppressants: a french retrospective multicenter study. | the clinical presentation and outcome of hepatitis e virus (hev) infection in inflammatory rheumatic diseases are unknown. we aimed to investigate the severity of acute hev infection and the risk of chronic viral replication in patients with inflammatory arthritides treated with immunosuppressive drugs. all rheumatology and internal medicine practitioners belonging to the club rhumatismes et inflammation in france were sent newsletters asking for reports of hev infection and inflammatory arthrit ... | 2015 | 25860212 |
| [clinical characteristics of hepatitis e virus infection in patients with hematological malignancies]. | 2015 | 25854474 | |
| identification and fine mapping of nuclear and nucleolar localization signals within the human ribosomal protein s17. | human ribosomal protein s17 (rps17) is mutated in diamond-blackfan anemia (dba), a bone marrow disorder that fails to produce sufficient red blood cells leading to anemia. recently, an rps17 protein sequence was also found to be naturally inserted in the genome of hepatitis e virus (hev) from patients chronically-infected by hev. the role of rps17 in hev replication and pathogenesis remains unknown due to the lack of knowledge about how rps17 functions at a molecular level. understanding the bio ... | 2015 | 25853866 |
| acute ataxic neuropathy associated with hepatitis e virus infection. | 2015 | 25847012 | |
| molecular detection of hepatitis e virus in sheep from southern xinjiang, china. | hepatitis e virus (hev) is a causative agent of infectious hepatitis in animals and humans both in developing and developed countries. here, we collected 500 sheep sera and 75 raw sheep liver samples from a slaughterhouse in the southern part of the xinjiang region, china, along with 26 sera of butchers from the same slaughterhouse. all serum samples were tested for anti-hev antibody by enzyme-linked immunosorbent assay. both serum and liver samples were evaluated for the presence of hev rna by ... | 2015 | 25833205 |
| expression and characterization of hepatitis e virus-like particles and non-virus-like particles from insect cells. | the hepatitis e virus (hev) capsid antigen expressed in insect cell has been proposed as a candidate subunit vaccine for the prevention of hepatitis e. however, the expression and purification of hev virus-like particles (vlps) from insect cells have not been explored. we aimed to optimize the procedure to obtain hev vlps. in this study, two conformations of the hev capsid proteins were expressed in insect cells, vlps and non-vlps, and they were purified separately. the physicochemical propertie ... | 2016 | 25824972 |
| distribution and molecular characterization of hepatitis e virus in domestic animals and wildlife in croatia. | hepatitis e is becoming a growing health concern in european countries as an increase of sporadic human cases of unknown origin has been recorded lately. its causative agent, hepatitis e virus (hev), is known to have zoonotic potential and thus the role of domestic and wild animals in the chain of viral spread should be considered when investigating risk factors and the epidemiology of the disease. a comprehensive survey based on viral rna detection was carried out in croatia including blood, sp ... | 2015 | 25820413 |
| declining prevalence of hepatitis e antibodies among danish blood donors. | the increasing incidence of reported hepatitis e cases in europe has focused attention on hepatitis e virus (hev) and the risk of transfusion-transmitted hepatitis e. the aim of this study was to investigate the prevalence of antibodies to hev (anti-hev) among danish blood donors in 2013 and to compare it to previous studies in denmark. in addition we wanted to compare the relative reactivity of two different assays. | 2015 | 25819381 |
| an outbreak of hepatitis e in an urban area of bangladesh. | we investigated an outbreak of jaundice in urban bangladesh in 2010 to examine the cause and risk factors and assess the diagnostic utility of commercial assays. we classified municipal residents reporting jaundice during the preceding 4 weeks as probable hepatitis e cases and their neighbours without jaundice in the previous 6 months as probable controls. we tested the sera collected from probable cases and probable controls for igm anti-hepatitis e virus (hev), and the igm-negative sera for ig ... | 2015 | 25817821 |
| [neuralgic amyotrophy associated to hepatitis e virus infection]. | 2015 | 25817452 | |
| hepatitis e epidemic, biratnagar, nepal, 2014. | 2015 | 25811975 | |
| prevalence of hepatitis e virus antibodies, israel, 2009-2010. | we investigated prevalence of hepatitis e virus in a sample of the population of israel. the overall seroprevalence of antibodies to the virus was 10.6% (95% ci 8.4%-13.0%); age-adjusted prevalence was 7.6%. seropositivity was associated with age, arab ethnicity, low socioeconomic status, and birth in africa, asia, or the former soviet union. | 2015 | 25811302 |
| hepatitis e in hemodialysis and kidney transplant patients in south-east italy. | to investigate the serovirological prevalence and clinical features of hepatitis e virus (hev) infection in end-stage renal failure patients and in the healthy population. | 2015 | 25805933 |
| prevalence of endemic pig-associated zoonoses in southeast asia: a review of findings from the lao people's democratic republic. | the increasing intensification of pork production in southeast asia necessitates an urgent requirement to better understand the dual impact of pig-associated zoonotic disease on both pig production and human health in the region. sharing porous borders with five countries and representing many regional ethnicities and agricultural practices, the lao people's democratic republic (lao pdr) appears well placed to gauge the levels of pig-associated zoonoses circulating in the wider region. despite t ... | 2015 | 25802431 |
| clinical features of hepatitis e virus infection in ibaraki, japan: autochthonous hepatitis e and acute-on-chronic liver failure. | hepatitis e caused by hepatitis e virus (hev) is a serious public health concern in developing countries where hev is mainly transmitted through contaminated water. recently, in industrialized countries, autochthonous hepatitis e, a porcine zoonosis, has been increasingly recognized. in japan, the number of national notifications of acute hepatitis e has increased since the introduction of anti-hev iga antibody measurement, covered by the national health insurance program, in 2011. in the past t ... | 2015 | 25797216 |
| structural basis for the neutralization of hepatitis e virus by a cross-genotype antibody. | hepatitis e virus (hev), a non-enveloped, positive-sense, single-stranded rna virus, is a major cause of enteric hepatitis. classified into the family hepeviridae, hev comprises four genotypes (genotypes 1-4), which belong to a single serotype. we describe a monoclonal antibody (mab), 8g12, which equally recognizes all four genotypes of hev, with ∼ 2.53-3.45 nm binding affinity. the mab 8g12 has a protective, neutralizing capacity, which can significantly block virus infection in host cells. ani ... | 2015 | 25793314 |
| late onset post-transfusion hepatitis e developing during chemotherapy for acute promyelocytic leukemia. | we herein report the case of a leukemia patient who developed hepatitis e seven months after undergoing a transfusion with contaminated blood products. the latency period in this case was significantly longer than that of typical hepatitis e. recently, chronic infection with hepatitis e virus (hev) genotype 3 has been reported in immunocompromised patients. there is a possibility that our patient was unable to eliminate the virus due to immunosuppression following chemotherapy and the administra ... | 2015 | 25786459 |
| design and production of a multiepitope construct derived from hepatitis e virus capsid protein. | the aim of this study was to design a high density multiepitope protein, which can be a promising multiepitope vaccine candidate against hepatitis e virus (hev). initially, conserved and antigenic helper t-lymphocyte (htl) epitopes in the hev capsid protein were predicted by in silico analysis. subsequently, a multiepitope comprising four htl epitopes with high-affinity binding to the hla molecules was designed, and repeated four times as high density multiepitope construct. this construct was s ... | 2015 | 25784455 |
| full genome analysis of a european-type genotype 3 hepatitis e virus variant obtained from a japanese patient with autochthonous acute hepatitis e. | a unique european-type hev strain (he-ja12-0725) classifiable into subgenotype 3f was recovered from a 66-year-old japanese female with autochthonous acute hepatitis e, and its entire genomic sequence was determined and characterized. the he-ja12-0725 strain shared the highest identity of 92.7% with a spanish swine isolate (eu723514) over the entire genome and possessed a long hypervariable region sequence of 111 amino acids, identical to the 3f strains of european origin. the patient had consum ... | 2015 | 25777997 |
| gb virus c viremia and anti-e2 antibody response among hemodialysis patients in gorgan, iran. | gb virus c is a blood-borne virus and a member of flaviviridae, like hepatitis c that is distributed globally and puts hemodialysis patients at high risk of developing liver disease. the clinical significance of gbv-c in this population remains unclear. | 2014 | 25774276 |
| hepatitis e virus: first description in a pet house rabbit. a new transmission route for human? | in this work, we identified for the first time hepatitis e virus (hev) in a pet house rabbit, an adult 7 years old female of domestic rabbit (oryctolagus cuniculus). importantly, the resulting phylogenetic tree showed that the hev strain identified in the pet house rabbit was closely related to a human hev sequence; this finding reawakens concerns regarding the zoonotic risk represented by hev in animals and expands to house rabbit the spectrum of potential source of infection for humans. potent ... | 2015 | 25773737 |
| hepatitis e: a disease of reemerging importance. | hepatitis e virus (hev) is the most common cause of acute viral hepatitis worldwide. originally considered to be restricted to humans, it is now clear that hev and hev-like viruses have several animal reservoirs with complex ecology and genetic diversity, as exemplified by the recent discovery of hev in dromedaries, a previously underestimated reservoir of zoonotic viruses prior to the emergence of middle east respiratory syndrome coronavirus. zoonotic foodborne transmission from pigs and feral ... | 2015 | 25773541 |
| prevalence of hepatitis e virus in populations of wild animals in comparison with animals bred in game enclosures. | hepatitis e virus (hev) is now accepted as a zoonotic virus, and domestic pigs, wild boars and deer are recognised as natural reservoirs of the pathogen. in this study, 762 animals (wild boars, fallow deer, red deer, sika deer, roe deer and mouflons) originating from the wild and from game enclosures were tested for the presence of hev rna by qrt-pcr. hev rna was detected in wild boars (96/450), red deer (2/169), roe deer (1/30) and mouflons (5/39). the sequence relationship between hev isolates ... | 2015 | 25771162 |
| hepatitis-e virus associated neuralgic amyotrophy with sustained plexus brachialis swelling visualized by high-resolution ultrasound. | 2015 | 25769655 | |
| experimental infection of pregnant rabbits with hepatitis e virus demonstrating high mortality and vertical transmission. | a high mortality rate of approximately 20% in pregnant women with hepatitis e has been reported in previous studies. however, other studies showed no difference between pregnant and nonpregnant women in the severity of hepatitis e. to determine the effects of hev infection on pregnancy, we successfully established hev infection in six pregnant rabbits (pr) and six nonpregnant rabbits (npr) with a rabbit hev isolate, taking three pr and one npr without hev infection as controls. tests for hev rna ... | 2015 | 25760656 |
| patients with diabetes mellitus are prone to develop severe hepatitis and liver failure due to hepatitis virus infection. | acute viral hepatitis (avh) is usually a self-limiting illness. diabetics are prone to develop liver diseases and liver regeneration is impaired in them. natural course of avh in diabetics has not been assessed and may be severe. | 2013 | 25755514 |
| hepatitis e and acute-on-chronic liver failure. | hepatitis e virus (hev) is the most common cause of acute viral hepatitis (avh) globally. it causes large scale epidemics of avh across the low- and middle income countries in asia and africa, and also causes sporadic cases of avh in the same geographical region. avh due to hev is usually an acute, self-limiting illness, similar in clinical presentation to avh caused by hepatitis a virus (hav). when hev causes avh in patients of chronic liver disease it may worsen rapidly to a syndrome called ac ... | 2013 | 25755504 |
| hepatitis e and acute liver failure in pregnancy. | hepatitis e virus is a positive strand rna virus with three open reading frames which is transmitted predominantly through the fecal contamination of water and food. it is the most common cause of acute liver failure in endemic areas. pregnant women especially from the indian subcontinent and africa are at increased risk of contracting acute hev infection as well as developing severe complications including alf. transmission of hev occurs from mother to unborn child. both maternal and fetal comp ... | 2013 | 25755503 |
| chronic hepatitis e virus infection and treatment. | it is now well accepted that hepatitis e virus (hev) infection can induce chronic hepatitis and cirrhosis in immunosuppressed patients. chronic genotype-3 hev infections were first reported in patients with a solid-organ transplant. thereafter, cases of chronic hev infection have been reported in patients with hematological disease and in those who are human immunodeficiency virus (hiv)-positive. hev-associated extra-hepatic manifestations, including neurological symptoms, kidney injuries, and h ... | 2013 | 25755487 |
| hepatitis e: epidemiology and natural history. | hepatitis e is a disease caused by infection with hepatitis e virus (hev). the virus has four genotypes, named 1 to 4, with one shared serotype. genotypes 1 and 2 infect only humans, whereas genotypes 3 and 4 primarily infect several mammalian animals, with occasional transmission to humans. evidence of infection with hev has been found in most parts of the world, with two distinct epidemiological patterns. in areas with high disease endemicity, primarily developing countries in asia and africa, ... | 2013 | 25755486 |
| hepatitis e: molecular virology and pathogenesis. | hepatitis e virus is a single, positive-sense, capped and poly a tailed rna virus classified under the family hepeviridae. enteric transmission, acute self-limiting hepatitis, frequent epidemic and sporadic occurrence, high mortality in affected pregnants are hallmarks of hepatitis e infection. lack of an efficient culture system and resulting reductionist approaches for the study of replication and pathogenesis of hev made it to be a less understood agent. early studies on animal models, sub-ge ... | 2013 | 25755485 |
| reduced expression of dna damage repair genes high mobility group box1 and poly(adp-ribose) polymerase1 in inactive carriers of hepatitis b virus infection-a possible stage of viral integration. | high mobility group box1 (hmgb1) and poly(adp-ribose) polymerase1 (parp1) proteins repair cellular dna damage. reduced expression of the corresponding genes can lead to an impaired dna damage repair mechanism. intracellular replication of hepatitis b virus (hbv) in such conditions can favor the integration of viral dna into host genome leading to the development of hepatocellular carcinoma (hcc). | 2013 | 25755481 |
| association of bell's palsy with hepatitis e virus infection: a rare entity. | hepatitis e virus (hev) infection is a common cause of acute hepatitis in india and other developing countries. the data regarding the neurologic manifestation of hev infection are limited. the neurologic disorders including guillain-barré syndrome, polyradiculopathy, neuralgic amyotrophy, encephalitis, bilateral brachial neuritis, ataxia/proximal myopathy, and acute transverse myelitis have been described. bell's palsy and other cranial nerve involvement in hepatitis a virus (hav) and hev infec ... | 2012 | 25755411 |
| atypical presentation of cytomegalovirus infection in a liver transplant patient. | cytomegalovirus (cmv) is the most common viral infection in solid organ transplant recipients. symptomatic infection usually presents with fever, pneumonia, colitis, or cytopenia. we describe a case of symptomatic cmv infection in a liver transplant recipient presenting with atypical symptoms of only persistent nausea and vomiting, in the absence of classical symptoms and signs; thus, highlighting the importance of high index of suspicion of cmv in immunocompromised patients, keeping in mind the ... | 2011 | 25755388 |
| 36 prevalence of hepatitis e virus infection among pregnant women in rajasthan. | 2011 | 25755367 | |
| chronic hepatitis e resolved by reduced immunosuppression in pediatric kidney transplant patients. | at present, transient asymptomatic hepatitis e virus (hev) infection is common among healthy adults in western europe, as reported by blood transfusion services. in immune-suppressed patients hev infection is often without clinical symptoms, but without therapeutic intervention it may become chronic and lead to cirrhosis. this report describes the course of chronic hev infection after kidney transplantation in 2 children, who cleared the virus after reduction in immunosuppressive therapy. if ami ... | 2015 | 25755234 |
| seroprevalence and incidence of hepatitis e in blood donors in upper austria. | in recent years various studies showed, that hepatitis e virus (hev) is a growing public health problem in many developed countries. therefore, hev infections might bear a transmission risk by blood transfusions. the clinical relevance still requires further investigations. the aim of this study was to provide an overview of acute hev infections in upper austrian blood donors as well as a risk estimation of this transfusion-related infection. | 2015 | 25751574 |
| seroprevalence of anti-hev igg in 182 polish patients. | hepatitis e virus (hev) infection is an emergent disease in developed countries. hev seroprevalence in such areas significantly exceeds values expected when one considers infection with this virus only as a problem restricted to classical endemic regions. to date, no related data are available in poland. in this study we aimed to obtain hev seroprevalence data and compare them with similar data for hepatitis a virus (hav) in polish patients. | 2015 | 25748623 |