Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| tear proteins of normal young hong kong chinese. | analysis of tear proteins is of diagnostic value for abnormal ocular conditions such as dry eye syndrome. many studies of tear proteins have been performed on caucasian subjects. however, little is known about these proteins in chinese eyes. | 2000 | 11045341 |
| high frequency of chromosome 3p deletion in histologically normal nasopharyngeal epithelia from southern chinese. | we have examined the presence of loss of heterozygosity (loh) on chromosome 3p in histologically normal nasopharyngeal epithelia (np), dysplastic lesions, and carcinoma of the nasopharynx from different ethnic and geographic regions. microdissected normal np from noncancerous individuals and nasopharyngeal carcinoma (npc) samples from both the high-risk group (southern chinese in hong kong) and two low-risk groups for npc (central/northern chinese in anhui/beijing and caucasians in toronto) were ... | 2000 | 11034072 |
| interspecies transmission and receptor recognition of influenza a viruses. | 2000 | 10941924 | |
| health beliefs and optimism as predictors of preventive health decisions in hong kong chinese. | the effects of components of the health belief model and optimism on preventive intention were examined in 144 hong kong chinese. two variables related to the health belief model, susceptibility and severity, were experimentally manipulated for an imaginary flu outbreak and a hypothetical vaccine. participants indicated their intention to take the hypothetical vaccine after reading each of the 4 combinations of high versus low susceptibility and severity. analysis suggested that both higher susc ... | 2000 | 10932559 |
| avian-to-human transmission of h9n2 subtype influenza a viruses: relationship between h9n2 and h5n1 human isolates. | in 1997, 18 cases of influenza in hong kong (bird flu) caused by a novel h5n1 (chicken) virus resulted in the deaths of six individuals and once again raised the specter of a potentially devastating influenza pandemic. slaughter of the poultry in the live bird markets removed the source of infection and no further human cases of h5n1 infection have occurred. in march 1999, however, a new pandemic threat appeared when influenza a h9n2 viruses infected two children in hong kong. these two virus is ... | 2000 | 10920197 |
| p53 polymorphism and human papillomavirus infection in hong kong women with cervical cancer. | in this study we investigated the involvement of p53 polymorphism at codon 72, the infection and typing of human papillomavirus (hpv) and the correlation of p53 polymorphism with hpv type and other clinicopathologic characteristics in 72 hong kong women with cervical cancer. we developed a simple and nonradioactive method for determining polymorphism at codon 72 of the p53 gene. the homozygous p53 arginine allele (arg/arg) was detected in 22 (31%), the homozygous p53 proline allele (pro/pro) in ... | 2000 | 10895031 |
| a simple restriction fragment length polymorphism-based strategy that can distinguish the internal genes of human h1n1, h3n2, and h5n1 influenza a viruses. | a simple molecular technique for rapid genotyping was developed to monitor the internal gene composition of currently circulating influenza a viruses. sequence information from recent h1n1, h3n2, and h5n1 human virus isolates was used to identify conserved regions within each internal gene, and gene-specific pcr primers capable of amplifying all three virus subtypes were designed. subtyping was based on subtype-specific restriction fragment length polymorphism (rflp) patterns within the amplifie ... | 2000 | 10878047 |
| a novel missense mutation (p191l) in the glucose-6-phosphate translocase gene identified in a chinese family with glycogen storage disease 1b. | 2000 | 10874322 | |
| continued circulation in china of highly pathogenic avian influenza viruses encoding the hemagglutinin gene associated with the 1997 h5n1 outbreak in poultry and humans. | since the outbreak in humans of an h5n1 avian influenza virus in hong kong in 1997, poultry entering the live-bird markets of hong kong have been closely monitored for infection with avian influenza. in march 1999, this monitoring system detected geese that were serologically positive for h5n1 avian influenza virus, but the birds were marketed before they could be sampled for virus. however, viral isolates were obtained by swabbing the cages that housed the geese. these samples, known collective ... | 2000 | 10864673 |
| acceptability of serum screening as an alternative to cytogenetic diagnosis of down syndrome among women 35 years or older in hong kong. | the addition of second trimester serum markers to maternal age increases the efficacy of screening for down syndrome by maternal age alone. among women aged 35 years or older, serum screening makes a large proportion of amniocentesis unnecessary. however, there are ethical and medicolegal concerns about serum screening in 'old' women, largely because some of the pregnancies affected by down syndrome and other chromosomal abnormalities may not be detected. we investigated the acceptability of ser ... | 2000 | 10861714 |
| oral colonization, phenotypic, and genotypic profiles of candida species in irradiated, dentate, xerostomic nasopharyngeal carcinoma survivors. | the aim of this study was to investigate oral yeast colonization and oral yeast strain diversity in irradiated (head and neck), dentate, xerostomic individuals. subjects were recruited from a nasopharyngeal carcinoma clinic and were segregated into group a (age, <60 years [n = 25; average age +/- standard deviation (sd), 48 +/- 6 years; average postirradiation time +/- sd, 5 +/- 5 years]) and group b (age, >/=60 years [n = 8; average age +/- sd, 67 +/- 4 years; average postirradiation time +/- s ... | 2000 | 10834980 |
| post-mortem investigations on stranded dolphins and porpoises from hong kong waters. | stranded cetaceans reported from the territorial waters of hong kong during the period may 1993 to march 1998 were examined to establish factors that may have contributed to their death. during the current study, 28 indo-pacific hump-backed dolphins (sousa chinensis), 32 finless porpoises (neophocaena phocaenoides), and four bottlenose dolphins (tursiops truncatus) were necropsied. bacteria (15 species) were isolated from nine animals. of these bacteria, 47% were of possible fecal origin reflect ... | 2000 | 10813617 |
| interspecies transmission of influenza viruses: h5n1 virus and a hong kong sar perspective. | this account takes stock of events and involvements, particularly on the avian side of the influenza h5n1 'bird flu' incident in hong kong sar in 1997. it highlights the role of the chicken in the many live poultry markets as the source of the virus for humans. the slaughter of chicken and other poultry across the sar seemingly averted an influenza pandemic. this perspective from hong kong sar marks the coming-of-age of acceptance of the role of avian hosts as a source of pandemic human influenz ... | 2000 | 10799786 |
| microcomputer-based workforce scheduling for hospital porters. | this paper focuses on labour scheduling for hospital porters who are the major workforce providing routine cleansing of wards, transportation and messenger services. generating an equitable monthly roster for porters while meeting the daily minimum demand is a tedious task scheduled manually by a supervisor. in considering a variety of constraints and goals, a manual schedule was usually produced in seven to ten days. to be in line with the strategic goal of scientific management of an acute car ... | 1999 | 10787496 |
| global epidemiology of influenza: past and present. | pandemics are the most dramatic presentation of influenza. three have occurred in the twentieth century: the 1918 h1n1 pandemic, the 1957 h2n2 pandemic, and the 1968 h3n2 pandemic. the tools of molecular epidemiology have been applied in an attempt to determine the origin of pandemic viruses and to understand what made them such successful pathogens. an excellent example of this avenue of research is the recent phylogenetic analysis of genes of the virus that caused the devastating 1918 pandemic ... | 2000 | 10774473 |
| the alpha-synuclein gene and parkinson disease in a chinese population. | to study the ala53thr and ala30pro mutations of the alpha-synuclein gene in a large number of chinese patients with parkinson disease (pd) as well as controls. | 2000 | 10768624 |
| rifapentine and isoniazid in the continuation phase of a 6-month regimen. interim report: no activity of isoniazid in the continuation phase. | clinical trial amongst 762 patients with newly diagnosed pulmonary tuberculosis in hong kong. after an initial 2 months of a four-drug intensive phase consisting of streptomycin, isoniazid, rifampicin and pyrazinamide (shrz), a random allocation in continuation to once-weekly rifapentine + isoniazid (hrp1), hrp1 given in 2 of every 3 weeks (hrp1.2/3), or to three times weekly isoniazid + rifampicin (hr3). | 2000 | 10751074 |
| incidence of highly genetically diversified vibrio parahaemolyticus in seafood imported from asian countries. | vibrio parahaemolyticus is an important pathogen of humans and aquacultured animals, especially in asian countries. in this study, we examined 686 samples of seafood imported from hong kong, indonesia, thailand and vietnam for v. parahaemolyticus. v. parahaemolyticus was recovered from 315 (45.9%) samples. the incidence of v. parahaemolyticus in products from hong kong and thailand was markedly higher than the incidence in products from indonesia and vietnam. the incidence rates in shrimp, crab, ... | 1999 | 10733249 |
| incidence and pathology of primary brain lymphoma in hong kong chinese patients. | primary brain lymphoma (pbl) is an uncommon extranodal lymphoma. its incidence is rapidly increasing in both immunocompromised and immunocompetent patients in western countries. eighteen cases of pbl were identified during a 16-year period among hiv negative patients in queen mary hospital, hong kong. one case of post-transplantation lymphoproliferative disease (ptld) was positive for epstein barr virus (ebv) encoded rna (eber) by in situ hybridization. all the remaining 17 immunocompetent cases ... | 2000 | 10721783 |
| influenza a pandemics of the 20th century with special reference to 1918: virology, pathology and epidemiology. | influenza a virus initiated worldwide epidemics (pandemics) in 1918, 1957, 1968 and 1977. a revised calculation of the 1918-1919 pandemic estimates that 40 million persons died and 500 million were infected. the mortalities in 1957 and 1968 were nearly 6 million. biological and genetic characteristics of the causative agents of the more recent pandemics, have been well studied but little is known about the causative agent of the great pandemic in 1918. genetic characterisation of the 1918 virus ... | 2000 | 10713598 |
| the monoamine oxidase b gene gt repeat polymorphism and parkinson's disease in a chinese population. | monoamine oxidase b (maob) metabolises dopamine and activates neurotoxins known to induce parkinsonism in humans and primates. therefore the maob gene (maob; xp15.21-4) is a candidate gene for parkinson's disease (pd). longer length dinucleotide repeat sequences in a highly polymorphic gt repeat region of intron 2 of this gene showed an association with pd in an australian cohort. we repeated this allele-association study in a population of 176 chinese pd patients (90 men, 86 women) and 203 agem ... | 2000 | 10701898 |
| characterization of the pathogenicity of members of the newly established h9n2 influenza virus lineages in asia. | the reported transmission of avian h9n2 influenza viruses to humans and the isolation of these viruses from hong kong poultry markets lend urgency to studies of their ecology and pathogenicity. we found that h9n2 viruses from north america differ from those of asia. the north american viruses, which infect primarily domestic turkeys, replicated poorly in inoculated chickens. phylogenetic analysis of the hemagglutinin and nucleoprotein genes indicated that the asian h9n2 influenza viruses could b ... | 2000 | 10662623 |
| novel tigr sequence alteration val53ala. | 2000 | 10644174 | |
| distinct pathogenesis of hong kong-origin h5n1 viruses in mice compared to that of other highly pathogenic h5 avian influenza viruses. | in 1997, an outbreak of virulent h5n1 avian influenza virus occurred in poultry in hong kong (hk) and was linked to a direct transmission to humans. the factors associated with transmission of avian influenza virus to mammals are not fully understood, and the potential risk of other highly virulent avian influenza a viruses infecting and causing disease in mammals is not known. in this study, two avian and one human hk-origin h5n1 virus along with four additional highly pathogenic h5 avian influ ... | 2000 | 10627555 |
| the influence of weather on human mortality in hong kong. | this study is the first attempt to investigate mortality seasonality and weather-mortality relationships in hong kong from 1980 to 1994. monthly mortality data from all causes of death, neoplasm, circulatory and respiratory diseases were obtained from the census and statistics department and the weather data were obtained from the hong kong observatory. regression analyses and anova were employed. significant winter peaks in sex specific and total deaths from all causes, circulatory and respirat ... | 2000 | 10626765 |
| population dynamics of the feral macaques in the kowloon hills of hong kong. | hong kong's feral monkey population is controversial. many people complain about the aggressiveness of the monkeys, while some conservationists urge the government to deal with the problem in a way that will not harm the monkeys. the population dynamics of the macaques in the kowloon hills were studied in 1992 and 1993. vital statistics are provided from this study as a first step in resolving the problems of human provisioning and wildlife management. it is unlikely that these macaques are indi ... | 2000 | 10588435 |
| detection of human herpesvirus 8 in cervical cells of chinese women with abnormal papanicolaou smears. | 1999 | 10585826 | |
| frequencies of defective cyp2c19 alleles in a hong kong chinese population: detection of the rare allele cyp2c19*4. | 1999 | 10585366 | |
| pancreatic solid-cystic-papillary tumor: clinicopathologic features in eight patients from hong kong and review of the literature. | solid-cystic-papillary tumors (scpts) of the pancreas are rare. the clinicopathologic features and pathogenesis of these tumors have attracted a number of investigations, but the results remain unclear. we investigated the clinicopathologic data, immunohistochemical expression of the pan-endocrine markers, hormones, steroid receptors, and p53 overexpression in pancreatic scpts from eight chinese patients (seven women, one man) collected over a 24-year period. they accounted for 2.5% of the prima ... | 1999 | 10512945 |
| human infection with influenza h9n2. | we report the clinical features of two cases of human infection with influenza a virus subtype h9n2 in hong kong, and show that serum samples from blood donors in hong kong had neutralising antibody suggestive of prior infection with influenza h9n2. | 1999 | 10489954 |
| genetic characterization of the pathogenic influenza a/goose/guangdong/1/96 (h5n1) virus: similarity of its hemagglutinin gene to those of h5n1 viruses from the 1997 outbreaks in hong kong. | analysis of the sequences of all eight rna segments of the influenza a/g oose/guangdong/1/96 (h5n1) virus, isolated from a sick goose during an outbreak in guangdong province, china, in 1996, revealed that the hemagglutinin (ha) gene of the virus was genetically similar to those of the h5n1 viruses isolated in hong kong in 1997. however, the remaining genes showed greater similarity to other avian influenza viruses. notably, the neuraminidase gene did no have the 19-amino-acid deletion in the st ... | 1999 | 10484749 |
| plasma insulin, growth hormone, cortisol, and central obesity among young chinese type 2 diabetic patients. | to examine the relationships between central obesity, insulin resistance index, plasma insulin, growth hormone (gh), and cortisol concentrations in 90 young chinese type 2 diabetic patients (aged 33+/-5 years) and 104 age- and sex-matched control subjects (aged 32+/-9 years). | 1999 | 10480508 |
| poultry and the influenza h5n1 outbreak in hong kong, 1997: abridged chronology and virus isolation. | 1999 | 10471177 | |
| international variation in the incidence of hip fractures: cross-national project on osteoporosis for the world health organization program for research on aging. | a cross-national study of hip fracture incidence was carried out in five geographic areas--beijing, china; budapest, hungary; hong kong; porto alegre, brazil; and reykjavik, iceland--during the years 1990-1992. cases of hip fracture among women and men of age 20 years and older were identified using hospital discharge data in conjunction with medical records, operating room logs, and radiology logs. estimated incidence rates varied widely, with beijing reporting the lowest rates (age-adjusted ra ... | 1999 | 10450414 |
| the clinicopathological significance of p21 and p53 expression in esophageal squamous cell carcinoma: an analysis of 153 patients. | the p21 gene is thought to play a central role in tumor suppression. the aim of this study was to examine the clinicopathological role of p21 and p53 in esophageal squamous cell carcinomas. | 1999 | 10445528 |
| molecular characterization of h9n2 influenza viruses: were they the donors of the "internal" genes of h5n1 viruses in hong kong? | the origin of the h5n1 influenza viruses that killed six of eighteen infected humans in 1997 and were highly pathogenic in chickens has not been resolved. these h5n1 viruses transmitted directly to humans from infected poultry. in the poultry markets in hong kong, both h5n1 and h9n2 influenza viruses were cocirculating, raising the possibility of genetic reassortment. here we analyze the antigenic and genetic features of h9n2 influenza viruses with different epidemiological backgrounds. the resu ... | 1999 | 10430948 |
| low yield of chest radiography in screening for active pulmonary tuberculosis in hiv-infected patients in hong kong. | this study assessed the usefulness of routine chest radiography for detecting active pulmonary tuberculosis in persons infected with human immunodeficiency virus (hiv) without suggestive symptoms in hong kong. tuberculosis is common in this locality and tuberculosis/hiv co-infection has been a frequent and significant problem. records of patients attending the largest hiv clinic were reviewed. three hundred and eleven routine chest radiographs were performed among 191 hiv-infected patients with ... | 1999 | 10414885 |
| antigenic and genetic analyses of h5 influenza viruses isolated from ducks in asia. | the hemagglutinin (ha) of six h5 influenza virus strains isolated from ducks in japan and china in 1976 to 1996 were analyzed antigenically and genetically. antigenic analysis using a panel of monoclonal antibodies revealed that the ha of h5 influenza viruses isolated from ducks are antigenically closely related to each other. phylogenetic analysis indicates that the isolates from ducks in hokkaido were derived from an ancestor common with the highly pathogenic isolates from chickens and humans ... | 1999 | 10414025 |
| frequent microsatellite instability and mismatch repair gene mutations in young chinese patients with colorectal cancer. | the incidence of colorectal cancer in persons under 46 years of age is substantially higher in hong kong than in scotland and many other countries. consequently, we examined whether there is a hereditary predisposition for colorectal cancer in this southern chinese population. | 1999 | 10413423 |
| case-control study of risk factors for avian influenza a (h5n1) disease, hong kong, 1997. | in may 1997, a 3-year-old boy in hong kong died of a respiratory illness related to influenza a (h5n1) virus infection, the first known human case of disease from this virus. an additional 17 cases followed in november and december. a case-control study of 15 of these patients hospitalized for influenza a (h5n1) disease was conducted using controls matched by age, sex, and neighborhood to determine risk factors for disease. exposure to live poultry (by visiting either a retail poultry stall or a ... | 1999 | 10395870 |
| human influenza: viral mutations and altered tropisms. | influenza is a virus that is capable of causing a pandemic of the human race. influenza has the ability to infect humans by mutating and altering its pathogenic characteristics. efforts must be made worldwide to educate people about the possibilities of a potential outbreak. awareness of optimal conditions which could lead to viral mutation and human to human transmission of a neogenetic strain of influenza appears to be a key deterrent against future cases. | 1999 | 10387491 |
| health services reform and human resource management in hong kong public hospitals. | this article discusses the empirical study of reform in the human resource management function in the hong kong hospital authority. it describes the prior management of the hospitals based on the civil service administration model before looking at management reform in general. from this research, the creative tensions between the centrifugal and centripetal forces in the pursuit of 'effectiveness', 'efficiency' and 'economy' are explored in terms of decentralization. a survey of line managers, ... | 1999 | 10351677 |
| management of niddm by family doctors in hong kong: a questionnaire survey. | the management approach to non-insulin-dependent diabetes mellitus among family doctors in hong kong was studied using two case histories. in 1996, all 804 fellows, members and associate members of the hong kong college of family physicians were sent a letter and a questionnaire. of the 512 who responded, 405 were male and 95 were female (12 were discarded) with ages ranging from 24 to 77 years (median 40). for the 48-year-old obese man who showed improvements in blood glucose and symptoms after ... | 1999 | 10344040 |
| avian strain of influenza a virus isolated from humans in hong kong. | 1999 | 10333647 | |
| the next influenza pandemic: lessons from hong kong, 1997. | the 1997 hong kong outbreak of an avian influenzalike virus, with 18 proven human cases, many severe or fatal, highlighted the challenges of novel influenza viruses. lessons from this episode can improve international and national planning for influenza pandemics in seven areas: expanded international commitment to first responses to pandemic threats; surveillance for influenza in key densely populated areas with large live-animal markets; new, economical diagnostic tests not based on eggs; cont ... | 1999 | 10221870 |
| hla dr2 and dq1 frequency among narcoleptic patients in hong kong chinese. | narcolepsy is a life-long crippling sleep disorder with significant physical and psychosocial impairments. although its exact etiology and neuropathology is not clear, a strong association with specific human leucocyte antigen (hla) subtype, particularly dr2 (drw15) and dqw1 (dqw6), has been demonstrated across different ethnic groups including caucasians and japanese. the presence of 100% association with hla dr2 in a series of hong kong chinese narcoleptic patients has previously been reported ... | 1998 | 10215015 |
| radon action level for high-rise buildings. | radon and its progeny are the major contributors to the natural radiation dose received by human beings. many countries and radiological authorities have recommended radon action levels to limit the indoor radon concentrations and, hence, the annual doses to the general public. since the sources of indoor radon and the methods for reducing its concentration are different for different types of buildings, social and economic factors have to be considered when setting the action level. but so far ... | 1999 | 10201568 |
| lack of allelic association of dopamine d4 receptor gene polymorphisms with parkinson's disease in a chinese population. | parkinson's disease (pd) is a neurodegenerative disease caused by a multitude of environmental, neurochemical, and genetic factors. the gene for human dopamine d4 receptor (drd4) has been considered as a plausible candidate for the pathogenesis of pd. different dopamine d4 receptor allelic forms have variable affinity toward certain neuroleptics such as clozapine, suggesting a role for dopamine d4 receptors in neurologic disorders. to test the hypothesis that the drd4 polymorphism is associated ... | 1999 | 10091613 |
| [h 5 n1 avian influenza in hong kong]. | 1998 | 10078053 | |
| detection of antibody to avian influenza a (h5n1) virus in human serum by using a combination of serologic assays. | from may to december 1997, 18 cases of mild to severe respiratory illness caused by avian influenza a (h5n1) viruses were identified in hong kong. the emergence of an avian virus in the human population prompted an epidemiological investigation to determine the extent of human-to-human transmission of the virus and risk factors associated with infection. the hemagglutination inhibition (hi) assay, the standard method for serologic detection of influenza virus infection in humans, has been shown ... | 1999 | 10074505 |
| rapid evolution of h5n1 influenza viruses in chickens in hong kong. | the h5n1 avian influenza virus that killed 6 of 18 persons infected in hong kong in 1997 was transmitted directly from poultry to humans. viral isolates from this outbreak may provide molecular clues to zoonotic transfer. here we demonstrate that the h5n1 viruses circulating in poultry comprised two distinguishable phylogenetic lineages in all genes that were in very rapid evolution. when introduced into new hosts, influenza viruses usually undergo rapid alteration of their surface glycoproteins ... | 1999 | 10074191 |
| biological heterogeneity, including systemic replication in mice, of h5n1 influenza a virus isolates from humans in hong kong. | an h5n1 avian influenza a virus was transmitted to humans in hong kong in 1997. although the virus causes systemic infection and is highly lethal in chickens because of the susceptibility of the hemagglutinin to furin and pc6 proteases, it is not known whether it also causes systemic infection in humans. the clinical outcomes of infection in hong kong residents ranged widely, from mild respiratory disease to multiple organ failure leading to death. therefore, to understand the pathogenesis of in ... | 1999 | 10074171 |
| microsatellite instability, epstein-barr virus, mutation of type ii transforming growth factor beta receptor and bax in gastric carcinomas in hong kong chinese. | microsatellite instability (mi), the phenotypic manifestation of mismatch repair failure, is found in a proportion of gastric carcinomas. little is known of the links between mi and epstein-barr virus (ebv) status and clinicopathological elements. examination of genes mutated through the mi mechanism could also be expected to reveal important information on the carcinogenic pathway. seventy-nine gastric carcinomas (61 ebv negative, 18 ebv positive) from local hong kong chinese population, an int ... | 1999 | 10027334 |
| l-myc genotypes in hong kong chinese colorectal carcinoma patients. | l-myc genotypes have been correlated with prognosis in different human tumors. its role in colorectal carcinoma (crc) is still unclear. this study aimed to assess the l-myc genotypes in 99 hong kong chinese crc patients by pcr-rflp techniques. the results obtained were correlated with clinical, histological and pathological parameters and genetic alterations. the observed frequency of l-myc genotypes (ll:ls:ss) was 27:46:26. the ratio of s to l alleles was 0.51:0.49. distribution of l-myc genoty ... | 1999 | 10023018 |
| characterization of the surface proteins of influenza a (h5n1) viruses isolated from humans in 1997-1998. | influenza a (h5n1) viruses infected humans in hong kong between may and december, 1997. sixteen viruses, including 6 from fatal cases, were isolated during this outbreak. molecular analysis of the surface proteins genes encoding the hemagglutinin (ha) and neuraminidase (na) of these h5n1 isolates, of a subtype not previously known to infect humans, are presented. the 16 human h5 ha sequences contain multiple basic amino acids adjacent to the cleavage site, a motif associated with highly pathogen ... | 1999 | 9927579 |
| the surface glycoproteins of h5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties. | in 1997, 18 confirmed cases of human influenza arising from multiple independent transmissions of h5n1 viruses from infected chickens were reported from hong kong. to identify possible phenotypic changes in the hemagglutinin (ha) and neuraminidase (na) of the h5 viruses during interspecies transfer, we compared the receptor-binding properties and na activities of the human and chicken h5n1 isolates from hong kong and of h5n3 and h5n1 viruses from wild aquatic birds. all h5n1 viruses, including t ... | 1999 | 9882316 |
| characterization of avian h5n1 influenza viruses from poultry in hong kong. | the transmission of avian h5n1 influenza viruses to 18 humans in hong kong in 1997 with six deaths established that avian influenza viruses can transmit to and cause lethal infection in humans. this report characterizes the antigenic and biological properties of the h5n1 influenza viruses isolated from chickens, ducks, and geese from farms and poultry markets in hong kong during 1997 and compares them with those of virus isolated from the index human case. each of the h5n1 viruses from hong kong ... | 1998 | 9878612 |
| no evidence for allelic association of a human ctla-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies. | the cytotoxic t lymphocyte associated-4 (ctla-4) gene is a candidate for t-cell mediated autoimmune disease and polymorphism has been reported to be associated with both type 1 diabetes and autoimmune thyroid disease. a previously unreported polymorphism of the promoter region of the human ctla-4 gene has recently been described in a sample of a normal control population. we investigated the distribution of this polymorphism, situated at position -318 to the atg start codon and resulting in a c- ... | 1998 | 9861324 |
| mantle cell lymphoma in the chinese: clinicopathological features and treatment outcome. | we report the clinical, molecular, and immunohistological findings of 20 chinese patients with mantle cell lymphoma diagnosed over a 10-year period. the disease affected mainly elderly patients (median age, 65.5 years) with a male predominance (m/f, 3/1). eighty percent presented with advanced stage iii/iv disease but only 25% had b symptoms. eighty-five percent had extranodal disease at presentation. complete remission (cr) and partial remission (pr) were achieved in 45% and 40% of the patients ... | 1998 | 9840910 |
| g209a mutation in the alpha-synuclein gene is rare and not associated with sporadic parkinson's disease. | 1998 | 9827625 | |
| pallister-killian syndrome: the first reported case in hong kong. | pallister-killian syndrome was first described in 1977 by pallister, et al. it is a multiple congenital anomalies/mental retardation syndrome caused by mosaic tetrasomy of chromosome 12p. the chromosomal abnormality is often missed if only peripheral lymphocytes are examined, and bone marrow or cultured skin fibroblasts may be required for confirmation. here we report the first case in hong kong. | 1998 | 9823681 |
| characterization of influenza a/hongkong/156/97 (h5n1) virus in a mouse model and protective effect of zanamivir on h5n1 infection in mice. | a recent outbreak of influenza in hong kong was caused by a highly virulent virus of avian origin. concern that the appearance of such a virus in the human population may be a harbinger of a new pandemic has brought increased attention to the issue of antivirals available for treatment of influenza. a/hongkong/156/97 (h5n1), the first virus of h5n1 subtype isolated from a human host, is highly virulent in the mouse model and can infect mouse lungs without requiring adaptation. high mortality and ... | 1998 | 9815209 |
| antimicrobial susceptibility of oral isolates of enterobacter cloacae and klebsiella pneumoniae from a southern chinese population. | the antibiotic susceptibilities of 59 enterobacter cloacae and 39 klebsiella pneumoniae human oral isolates collected from a southern chinese population in hong kong were investigated for their susceptibility to eight antibiotics: ampicillin, cephalothin, cefuroxime, ceftazidime, ciprofloxacin, gentamicin, tetracycline and trimethoprim/sulfamethoxazole using the e-test method for direct quantification of minimum inhibitory concentrations. most strains were sensitive to all antibiotics except amp ... | 1998 | 9807124 |
| incident reporting in acute pain management. | incident reporting is an effective tool for continuous quality improvement in clinical practice. a prospective study on voluntary incident reporting in pain management was conducted at a major teaching hospital in hong kong. over a 12-month period, 53 incidents were reported in 1275 patients who received pain relief treatments which were supervised by the acute pain service. the majority of the incidents were first detected by the pain team. the most common incidents involved delivery circuits, ... | 1998 | 9797515 |
| family capital and hong kong adolescents' academic achievement. | this study examined relationships between the economic, human, social, and cultural capital of families and adolescents' academic achievement. data were collected from 387 14-yr.-old hong kong students (187 girls, 200 boys), who completed questionnaires to assess their perceptions of the various dimensions of family capital. academic achievement was measured by performance in chinese language, english language, and mathematics. the findings indicated that different combinations of the dimensions ... | 1998 | 9775666 |
| nasopharyngeal carcinoma research in hong kong in the past decade. | to review the research carried out in hong kong on nasopharyngeal carcinoma (npc) over the past 10 years. | 1997 | 9772411 |
| proposed cd4(+) t-cell criteria for staging human immunodeficiency virus-infected chinese adults. | the present treatment, prophylaxis, and prognostic staging of human immunodeficiency virus (hiv) disease rely heavily on peripheral cd4(+) t lymphocyte (cd4) changes. we correlated the clinical course of events and cd4 changes among consecutive hiv-infected ethnic chinese adults in hong kong. using death as end point, the estimated proportion survival and death incidences were used to compare cdc and proposed staging criteria based on stratified baseline cd4. a separate set of baseline cd4 per m ... | 1998 | 9756719 |
| [influenza a (h5n1) in hong kong: forerunner of a pandemic or just a scientifically interesting phenomenon and a useful exercise in pandemiology?]. | in 1997, 18 influenza patients were detected who were infected with influenza a(h5n1) virus. six patients died. presumably most of the patients had acquired the infection directly from chickens with the fowl plague prevalent in china in 1997. these are the first reported cases of isolation of influenza viruses belonging to one of the h4-h15 subtypes from human influenza patients. man-to-man transmission of the virus has not been demonstrated but cannot be excluded in every case. genetic analyses ... | 1998 | 9749297 |
| bird flu vaccine. | 1998 | 9735000 | |
| detection of trisomy 3 in primary gastric b-cell lymphoma by using chromosome in situ hybridization on paraffin sections. | recent studies in western populations have shown that trisomy 3 is the most frequent chromosomal abnormality in primary gastric lymphoma (pgl). to study the incidence of trisomy 3 and its implications for the pathogenesis of pgl in hong kong, we have applied the technique of chromosome in situ hybridization in 13 cases of pgl by using archival paraffin-embedded tissue sections. five cases of chronic gastritis were used as controls. trisomy 3 was found in 9 (69%) of 13 cases, including cases of l ... | 1998 | 9728610 |
| laboratory containment for influenza a h5n1 virus: level 2, level 3, or level 3+? | the recent alert over bird flu (influenza a h5n1) in hong kong has ruffled feathers in some countries, including the united kingdom, as to how the virus should be handled in clinical and research laboratories. | 1998 | 9718852 |
| mercury and organochlorine exposure from fish consumption in hong kong. | the average person in hong kong consumes fish or shellfish four or more times a week averaging about 60 kg of fish per year. even though the mean mercury level in store-bought hong kong fish was only 0.12 mg/kg, corroborating evidence is presented from numerous studies to support the view that mercury bioaccumulates. by the time a typical hong kong male reaches 30 years of age he will have accumulated approximately 4 mg/kg mercury in his hair. by age 60, his hair mercury levels will have increas ... | 1998 | 9717248 |
| influenza a(h5n1). | 1998 | 9707895 | |
| requirements for the electronic crossmatch. | with the integration of laboratory information systems into transfusion services, it is now possible to develop standard operating procedures (sops) for an electronic crossmatch (exm) to replace the immediate-spin crossmatch for detecting abo incompatibility between the blood sample submitted for pre-transfusion testing and the donor unit selected for transfusion. essential to the safety of an exm are requirements that: 1) the computer contains logic to prevent assignment and release of abo inco ... | 1998 | 9704475 |
| [influenza remains an unpredictable infection]. | influenza virus a (h5n1) was isolated from the tracheal swab of a 3-year-old boy who died from influenza with the raye syndrome in hong kong in may, 1997. up to the present time, influenza viruses with hemagglutinin h5 were known to circulate only among birds. they caused a variety of diseases: from asymptomatic to epizootic with 100% mortality, particularly among chickens. the main difference between virulent and avirulent strains is as follows: virulent viruses are isolated from all tissues of ... | 1998 | 9702816 |
| hiv-associated eosinophilic folliculitis in a chinese woman: a case report and a survey in hong kong. | this is the first survey of eosinophilic folliculitis (ef) in patients infected with the human immunodeficiency virus (hiv) in hong kong. the present report provides the local data on hiv-associated eosinophilic folliculitis (hiv-ef) and includes the first chinese, heterosexual female patient with this condition. this is a retrospective study on all hiv-positive patients (n = 451) attending the outpatient clinic of the aids unit in hong kong. patients diagnosed as having ef with histological sup ... | 1998 | 9702601 |
| human influenza virus a/hongkong/156/97 (h5n1) infection. | introduction of influenza viruses with gene segments of avian origin into the human population may result in the emergence of new pathogenic human influenza viruses. the recent infection of a 3-year-old boy with an influenza a (h5n1) virus of avian origin can be considered as an example of such an event. however, this virus, influenza a/hong kong/156/97 (h5n1) and the 17 additional h5n1 viruses isolated from humans by the end of 1997 lack the ability to spread efficiently amongst humans and ther ... | 1998 | 9682346 |
| second-trimester maternal serum alpha-fetoprotein and human chorionic gonadotrophin screening for down's syndrome in hong kong. | second-trimester maternal serum screening for fetal down's syndrome is well established in many western countries. its usefulness and acceptability is unknown in the asian countries. between june 1994 and december 1996, we offered second-trimester serum afp and hcg screening to pregnant women in hong kong who were less than 35 years old and without other risk factors for chromosome abnormalities. each woman was assigned a risk of having a down's syndrome term pregnancy by using a computer softwa ... | 1998 | 9664604 |
| comparisons of highly virulent h5n1 influenza a viruses isolated from humans and chickens from hong kong. | genes of an influenza a (h5n1) virus from a human in hong kong isolated in may 1997 were sequenced and found to be all avian-like (k. subbarao et al., science 279:393-395, 1998). gene sequences of this human isolate were compared to those of a highly pathogenic chicken h5n1 influenza virus isolated from hong kong in april 1997. sequence comparisons of all eight rna segments from the two viruses show greater than 99% sequence identity between them. however, neither isolate's gene sequence was clo ... | 1998 | 9658115 |
| hong kong male subfertility links to mercury in human hair and fish. | the focus of the present study was on the relationship between hong kong male subfertility and fish consumption. mercury concentrations found in the hair of 159 hong kong males aged 25-72 (mean age = 37 years) was positively correlated with age and was significantly higher in hong kong subjects than in european and finnish subjects (1.2 and 2.1 ppm, respectively). mercury in the hair of 117 subfertile hong kong males (4.5 ppm, p < 0.05) was significantly higher than mercury levels found in hair ... | 1998 | 9646524 |
| [the threat of an influenza pandemic]. | 1998 | 9611870 | |
| [influenza a(h5n1): current status]. | 1998 | 9599174 | |
| coming full circle: osteopathic manipulative treatment and immunity. | 1998 | 9594483 | |
| assisted reproduction technology in queen mary hospital: ten years' experience. | to review the experience of an assisted reproduction program. | 1997 | 9594245 |
| emerging pathogens: the hong kong experience. | 1997 | 9594216 | |
| update: isolation of avian influenza a(h5n1) viruses from human beings--hong kong, 1997-1998. | 1998 | 9581152 | |
| specific latent membrane protein 1 gene sequences in type 1 and type 2 epstein-barr virus from nasopharyngeal carcinoma in hong kong. | we reported previously that a characteristic epstein-barr virus latent membrane protein 1 (ebv-lmp1) gene was associated with nasopharyngeal carcinoma (npc) in hong kong. it showed a 30 bp deletion at the carboxyl terminus with specific amino acid substitution asp at codon 335 with reference to gly in b95-8 lmp1. this deletion variant asp335 was present in over 90% of npc biopsy specimens. the present study attempted to determine the whole encoding sequence of the lmp1 gene in different ebv isol ... | 1998 | 9579578 |
| development of an anthropometric database for hong kong chinese cad operators. | with the increasing popularity of using computer-aided design (cad) in hong kong, it is time to look into the design of a suitable workplace for the cad operators working in the industries. this can be achieved by applying anthropometric data into the design for enhancing performance and reducing musculoskeletal problems. in order to avoid any mismatches in anthropometric dimensions, which is believed to be one of the main causes of fatigue and occupational illness among workers, in the workplac ... | 1996 | 9551130 |
| emerging infectious diseases attract expert attention. | 1998 | 9525378 | |
| experiences in hong kong with the theory and practice of the albumin column method of sperm separation for sex selection. | controversy still surrounds the human serum albumin (hsa) method for separation of x- and y-bearing human spermatozoa. there is doubt about whether the procedure does enrich sperm samples for the chosen sex chromosome. we have applied the hsa separation method in a clinic in hong kong, using the method as described by ericsson et al. [nature, 246, 421-424 (1973)] taking care to keep the sperm recovery to <5% of the initial number. aliquots of separated spermatozoa were examined for x- and y-bear ... | 1998 | 9512247 |
| new strain of influenza type a in hong kong. | 1998 | 9510116 | |
| investigators present latest findings on hong kong 'bird flu' to the fda. | 1998 | 9496966 | |
| chinese avian influenza. | 1998 | 9487160 | |
| avian influenza. | 1998 | 9484264 | |
| human influenza a h5n1 virus related to a highly pathogenic avian influenza virus. | in may, 1997, a 3-year-old boy in hong kong was admitted to the hospital and subsequently died from influenza pneumonia, acute respiratory distress syndrome, reye's syndrome, multiorgan failure, and disseminated intravascular coagulation. an influenza a h5n1 virus was isolated from a tracheal aspirate of the boy. preceding this incident, avian influenza outbreaks of high mortality were reported from three chicken farms in hong kong, and the virus involved was also found to be of the h5 subtype. | 1998 | 9482438 |
| clinical features and rapid viral diagnosis of human disease associated with avian influenza a h5n1 virus. | human infection with an avian influenza a virus (subtype h5n1) was reported recently in hong kong. we describe the clinical presentation of the first 12 patients and options for rapid viral diagnosis. | 1998 | 9482437 |
| influenza as a zoonosis: how likely is a pandemic? | 1998 | 9482431 | |
| influenza a virus subtype h5n1 infection in hong kong--update. | 1998 | 9476418 | |
| avian influenza results in depopulation in hong kong. | 1998 | 9470033 | |
| from the centers for disease control and prevention. update: isolation of avian influenza a(h5n1) viruses from humans--hong kong, 1997-1998. | 1998 | 9459456 |