Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| significance of high-risk human papillomavirus dna detection in women 50 years and older with squamous cell papanicolaou test abnormalities. | data on cytologic screening and follow-up disproportionately reflect findings from frequently screened younger women, and data from screened women 50 years and older using newer screening technologies remain limited. | 2010 | 20670132 |
| human papillomavirus and oropharynx cancer: biology, detection and clinical implications. | to review evidence for the role of human papillomavirus (hpv) in the etiology of oropharyngeal cancers, methods of viral detection, and the resulting clinical implications. | 2010 | 20669304 |
| verrucous carcinoma masquerading as a giant fibroepithelial polyp. | the authors report a case of a verrucous carcinoma (vc) of the buttocks clinically simulating a giant (6.5 cm in length and 5.4 cm in greatest diameter) fibroepithelial polyp (fep) capped by a large cutaneous horn. the growth had been present for 15 years and had never been biopsied despite numerous physical exams. vc typically presents distinctly as a large cauliflower-like growth with histological features of acanthosis, parakeratosis, minimal cytological atypia, and deep pushing epithelial bo ... | 2010 | 20667928 |
| electrochemical biosensor for the multiplexed detection of human papillomavirus genes. | a proof-of-concept of an electrochemical genosensor array for the individual and simultaneous detection of two high-risk human papillomavirus dna sequences, hpv16e7p and hpv45e6 that exhibits high sensitivity and selectivity is reported. the optimum conditions for surface chemistry preparation and detection of hybridised target were investigated. the lod obtained are in the pm range, which are sufficient for most real rna/dna samples obtained from pcr amplification, usually in the nanomolar rang ... | 2010 | 20667709 |
| prevalence, concordance and determinants of human papillomavirus infection among heterosexual partners in a rural region in central mexico. | although human papillomavirus (hpv) infection in heterosexual couples has been sparsely studied, it is relevant to understand disease burden and transmission mechanisms. the present study determined the prevalence and concordance of type-specific hpv infection as well as the determinants of infection in heterosexual couples in a rural area of mexico. | 2010 | 20667085 |
| e1--e4-mediated keratin phosphorylation and ubiquitylation: a mechanism for keratin depletion in hpv16-infected epithelium. | the keratin if network of epidermal keratinocytes provides a protective barrier against mechanical insult, it is also a major player in absorbing stress in these cells. the human papilloma virus (hpv) type 16 e1--e4 protein accumulates in the upper layers of hpv16-infected epithelium and is known to associate with and reorganise the keratin if network in cells in culture. here, we show that this function is conserved amongst a number of hpv alpha-group e1--e4 proteins and that the differentiatio ... | 2010 | 20663917 |
| polymorphism in exon 4 of tp53 gene associated to hpv 16 and 18 in mexican women with cervical cancer. | cervical cancer (cc) is the second most common cancer in mexican women. human papillomavirus (hpv) infection is necessary but not sufficient for cc development. furthermore, genetic factors as polymorphisms could be important susceptibility factors. controversial results regarding tp53 polymorphisms specifically in codon 72 of cc have been reported. in the present work, the exon 4 sequence of tp53 gene in cc and healthy mexican-mestizo women were analyzed. a group of 111 women with cc and 126 he ... | 2010 | 20661667 |
| squamous cell carcinoma arising from human papillomavirus associated cyst. | 2011 | 20661120 | |
| special commentary: patient safety and the next generation of hpv dna tests. | human papillomavirus (hpv) testing is more sensitive for the detection of cervical precancer and cancer than cervical cytology. the increased sensitivity of hpv testing and cytology combined ("cotesting") compared to cytology alone permitted professional societies to recommend 3-year screening intervals among the cotest-negative results. however, there is an increasing recognition that both clinical sensitivity and specificity of cervical cancer screening are important to patient safety and must ... | 2010 | 20660320 |
| hpv e6 down-regulation and apoptosis induction of human cervical cancer cells by a novel lipid-soluble extract (pe) from pinellia pedatisecta schott in vitro. | to evaluate the cytotoxicity and apoptosis induction effects of a novel lipid-soluble extract (pe) from pinellia pedatisecta schott on caski, hela and hbl-100 cells. particularly, the effect of pe on hpv e6 gene expression was tested, and the mechanism of its apoptosis induction effect was also studied. | 2010 | 20659543 |
| primary carcinoma of the vagina. | in this paper we reviewed the risk factors for primary carcinoma of the vagina (pcv), diagnostic and therapeutic modalities, and principles leading to rational decision-making in the individualized management of vaginal carcinoma patients. the review was based on the recent literature and our own years- long experience with the disease. pcv is a rare gynecologic malignancy accounting for about 2% of all neoplasms of the female genitals. most of the affected women are over 60 years of age, peakin ... | 2010 | 20658716 |
| clustering of concordant and discordant cancer types in swedish couples is rare. | spouses are exposed to common environmental cancer risk factors during adulthood. investigating the aggregation of cancer in couples might provide valuable insights into cancer development. | 2011 | 20655736 |
| prevalence of human papillomavirus genotypes in hiv-1-infected women in seattle, usa and nairobi, kenya: results from the women's hiv interdisciplinary network (whin). | hiv-infected women have a high prevalence of human papillomavirus (hpv) infection and are more likely to be infected with hpv genotypes that are considered high-risk and have the potential for progressing to cervical cancer. the currently available hpv vaccines protect against specific hpv genotypes that may not be the most important causes of dysplasia and potentially of cervical cancer in hiv-1-infected women. african women have been underrepresented in the studies of global prevalence of hpv ... | 2010 | 20655263 |
| merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin. | polyomaviruses have been linked to diseases of immunosuppressed patients. we sought to determine the prevalence of merkel cell polyomavirus in benign epithelial skin neoplasms and nonmelanoma skin cancer of immunosuppressed renal transplant recipients and long-term dialysis patients. merkel cell polyomavirus dna was detected by polymerase chain reaction (pcr) in 2 (10%) of 20 patients, in carcinomas in situ (bowen's disease). in one of our patients with merkel cell polyomavirus-positive carcinom ... | 2010 | 20655089 |
| [correlation between human papillomavirus type 16 infection and human leukocyte antigen class i expression in cervical cancers of uighur women]. | to explore the relationship between human papillomavirus(hpv) infection and expression of human leukocyte antigen class i (hla-i) family genes (hla-a, b and c) in cervical cancers of uighur women, and to investigate their effect on cervical cancer progression. | 2010 | 20654125 |
| the effect of school-based cervical cancer education on perceptions towards human papillomavirus vaccination among hong kong chinese adolescent girls. | objective: to evaluate the effects of school-based cervical cancer education on hong kong chinese adolescent girls. methods: adolescent girls (n=953) in local secondary schools attended a tailored educational program on cervical cancer prevention. self-administered questionnaires were used before and after the program to measure its effects on participants' knowledge, attitude and perceived social norms towards human papillomavirus (hpv) vaccination and their intention to be hpv vaccinated. resu ... | 2010 | 20650592 |
| elevated systemic levels of inflammatory cytokines in older women with persistent cervical human papillomavirus infection. | defects in lymphoproliferative responses to mitogens/antigens in women >45 years old with a persistent type-specific human papillomavirus (hpv) infection have been reported. | 2010 | 20647411 |
| four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial. | to evaluate the prophylactic efficacy of the human papillomavirus (hpv) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata). | 2010 | 20647284 |
| efforts to counteract locally the effects of systemic immunosupression: a review on the use of imiquimod, a topical immunostimulator in organ transplant recipients. | the potent systemic immunosuppression therapy necessary to sustain a life-saving solid organ transplant is associated with an increased incidence of various infections including human papillomavirus infection and skin cancers in organ transplant recipients. imiquimod, a topical agent that functions through local induction of a specific anti-viral or anti-tumor immune response, appears to be a promising therapeutic option that could potentially counteract in situ the effects of systemic immunosup ... | 2010 | 20646334 |
| unexpected upper airway obstruction due to disseminated human papilloma virus infection involving the pharynx in a parturient. | human papilloma virus has been implicated as the cause of juvenile-onset recurrent respiratory papillomatosis in first-born children. thus, cesarean section is strongly recommended by obstetricians to avoid direct contact with papilloma in an infected birth canal. we report a parturient with silent hypopharyngeal papilloma, which was associated with severe clinical problems at the induction of general anesthesia. the anesthesiologist considered general anesthesia for this case because of dissemi ... | 2010 | 20643367 |
| human papillomavirus in head and neck tumors: epidemiological, molecular and clinical aspects. | high-risk types of human papillomaviruses (hr hpv) play an important role in the etiology of a group of head and neck squamous cell cancers (hnscc). this review is focused on epidemiological, molecular, and clinical aspects of hpv infection in head and neck cancer. high risk hpv dna is being detected in a very different proportion of hnscc with the highest prevalence in oropharynx. patients with hpv-associated tumors are characterized by moderate tobacco and alcohol consumption. some aspects of ... | 2010 | 20640929 |
| the e2f5 repressor is an activator of e6/e7 transcription and of the s-phase entry in hpv18-associated cells. | high-risk papillomavirus type 18 (hpv18) is one of the less represented hpv types in low-grade lesions of the anogenital tract, whereas it occupies the second place in cervical cancer, where it can be found in 16% of the cases worldwide, after hpv16 present in 54% of them. these epidemiological data indicate that hpv18 infection is more prone to carcinogenic progression. the main oncogenic proteins, e6 and e7 of hpv18, are functionally comparable to the homologous proteins of the other high-risk ... | 2010 | 20639900 |
| hpv mrna test in women with minor cervical lesions: experience of the university hospital of north norway. | in the norwegian cervical cancer screening programme tests for detection of human papillomavirus (hpv) are used to triage women with minor cytological cervical lesions. the material in this study comprises samples from 1798 women in the period 2006-2008. the hpv test was performed according to the guidelines of the norwegian cancer registry. the hpv mrna test (pretect hpv-proofer) detects and types 5 high-risk genotypes (16, 18, 31, 33 and 45). the hpv mrna results were compared to cytology and ... | 2010 | 20638416 |
| detection and typing of low-risk human papillomavirus genotypes hpv 6, hpv 11, hpv 42, hpv 43 and hpv 44 by polymerase chain reaction and restriction fragment length polymorphism. | a novel pcr-restriction fragment length polymorphism assay (pcr-rflp) was developed for sensitive detection and reliable differentiation of five low-risk human papillomavirus (lr-hpv) genotypes: hpv 6, hpv 11, hpv 42, hpv 43 and hpv 44, as well as differentiation of prototypic and non-prototypic hpv 6 genomic variants. the assay is based on the amplification of a 320-bp fragment of the hpv e1 gene and subsequent analysis of pcr-products with bsaji and hinfi. testing on plasmid standards showed t ... | 2010 | 20637805 |
| establishment of an efficient multiplex real-time pcr assay for human papillomavirus genotyping in cervical cytology specimens: comparison with hybrid capture ii. | j.-h. lee, n.-w. lee, s.-w. hong, y.-s. nam, j.-w. choi and y.-s. kim establishment of an efficient multiplex real-time pcr assay for human papillomavirus genotyping in cervical cytology specimens: comparison with hybrid capture ii objective: to establish an efficient multiplex real-time pcr assay for 15 human papillomavirus (hpv) genotypes, we designed multiplexing parameters and compared our pcr system with the hybrid capture (hc) ii test using cervical cytology samples. methods: for preventin ... | 2010 | 20636403 |
| [primary squamous cell carcinoma of the rectum]. | primary squamous cell carcinoma of the colon and rectum is rare. it presents clinically as other types of colorectal cancer and the treatment is primarily surgery. the pathogenesis is unclear, but several hypotheses have been suggested, including human papilloma virus infection. gynaecological cancer is an important differential diagnosis in females with involvement of the genital organs. | 2010 | 20633345 |
| human papillomavirus-mediated carcinogenesis and hpv-associated oral and oropharyngeal squamous cell carcinoma. part 2: human papillomavirus associated oral and oropharyngeal squamous cell carcinoma. | human papillomavirus (hpv) infection of the mouth and oropharynx can be acquired by a variety of sexual and social forms of transmission. hpv-16 genotype is present in many oral and oropharyngeal squamous cell carcinomata. it has an essential aetiologic role in the development of oropharyngeal squamous cell carcinoma in a subset of subjects who are typically younger, are more engaged with high-risk sexual behaviour, have higher hpv-16 serum antibody titer, use less tobacco and have better surviv ... | 2010 | 20633288 |
| the manitoba human papillomavirus vaccine surveillance and evaluation system. | with the recent introduction of a human papillomavirus (hpv) vaccine in canada, it is important to establish surveillance and evaluation programs that not only track the uptake of the vaccine, but also assess its safety and its impact on: distribution of hpv type, cervical cancer screening programs, the incidence of anogenital warts, precancerous lesions and various cancers, and sexual behaviour. | 2010 | 20632523 |
| the human papillomavirus type 16 e6 oncoprotein activates mtorc1 signaling and increases protein synthesis. | the mammalian target of rapamycin (mtor) kinase acts as a cellular rheostat that integrates signals from a variety of cellular signal transduction pathways that sense growth factor and nutrient availability as well as intracellular energy status. it was previously reported that the human papillomavirus type 16 (hpv16) e6 oncoprotein may activate the s6 protein kinase (s6k) through binding and e6ap-mediated degradation of the mtor inhibitor tuberous sclerosis complex 2 (tsc2) (z. lu, x. hu, y. li ... | 2010 | 20631133 |
| randomized trial of an alternate human papillomavirus vaccine administration schedule in college-aged women. | human papillomavirus (hpv) vaccine is effective against hpv types 16 and 18, which cause 70% of cervical cancers. the three-dose vaccination schedule at 0, 2, and 6 months may be inconvenient for college-aged women. this study assessed noninferiority of the immune response to an alternate vaccination schedule at 0, 2, and 12 months. | 2010 | 20629576 |
| multi-site study of hpv type-specific prevalence in women with cervical cancer, intraepithelial neoplasia and normal cytology, in england. | knowledge of the prevalence of type-specific human papillomavirus (hpv) infections is necessary to predict the expected, and to monitor the actual, impact of hpv immunisation and to design effective screening strategies for vaccinated populations. | 2010 | 20628396 |
| monitoring hpv16/18 immunisation in england and elsewhere. | 2010 | 20628394 | |
| detection of human papillomavirus types 33 and 56 in extragenital bowen's disease involving the sole. | 2010 | 20627853 | |
| tobacco smoking and regression of low-grade cervical abnormalities. | the role of tobacco smoking in the multistage carcinogenesis at the cervix is not fully understood because of a paucity of prospective data. to assess the relationship between smoking and spontaneous regression of cervical precursor lesions, a total of 516 women with low-grade squamous intraepithelial lesion (lsil) were monitored by cytology and colposcopy every 4 months. probability of lsil regression within 2 years was analyzed in relation to smoking behaviors, with regression defined as at le ... | 2010 | 20626752 |
| interferon-tau: current applications and potential in antiviral therapy. | interferon-tau (ifn-tau) was initially identified as an ovine pregnancy protein. produced by the trophoblast, it is important in preventing degradation of the corpus luteum and has been used as an early marker for ovine pregnancy. as a member of the family of type i interferons, ifn-tau has demonstrated promising antiviral activity against human viral infections in vitro. additionally, it displays high species cross-reactivity despite its absence in humans. to date, ifn-tau has shown efficacy in ... | 2010 | 20626290 |
| cost-effectiveness analysis of hpv vaccination alongside cervical cancer screening programme in slovenia. | the objective of the present study is to evaluate the cost-effectiveness of human papillomavirus (hpv) vaccination alongside cervical cancer screening programme in slovenia. | 2010 | 20624834 |
| human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3. | there are few large case series describing the human papillomavirus (hpv) genotypes found in women diagnosed with rigorously reviewed cervical intraepithelial neoplasia grade 3 (cin3), cervical precancer. | 2010 | 20615885 |
| human papillomavirus (hpv) related carcinomas of the upper aerodigestive tract. | epidemiologic, clinical, morphologic and molecular evidence show that high risk hpv, particularly type 16, is a prerequisite for some carcinomas of the upper aerodigestive tract (uadt), particularly tonsil and base of tongue. sexual transmission is an important mode of infection while tobacco use and excessive drinking are not considered risk factors. hpv + tumors are distinct clinically and pathologically. they are more common in young patients (<40 years) with a male to female ratio of 4:1. th ... | 2007 | 20614273 |
| [verrucous carcinoma of penis: a case report]. | we report a case of verrucous carcinoma of the penis. a 62-year-old man, who presented with penile swelling and pain, was referred to our hospital. although, penile tumor biopsy revealed no evidence of malignancy, the patient presented with penile swelling and discharge. the penis was surgically resected and urinary diversion was performed. the pathological examination of the resected glans revealed verrucous carcinoma of penis. furthermore, in situ hybridization revealed human papilloma virus ( ... | 2010 | 20610928 |
| efficacy of human papillomavirus type 16/18 as04-adjuvanted vaccine in japanese women aged 20 to 25 years: final analysis of a phase 2 double-blind, randomized controlled trial. | human papillomavirus (hpv) type 16/18 as04-adjuvanted vaccine was shown to be highly immunogenic and generally well tolerated in the interim analysis of a phase 2 double-blind, randomized controlled multicenter study in japanese healthy women aged 20 to 25 years. vaccine efficacy, immunogenicity, and safety are assessed in this study through 24 months after the first vaccination. | 2010 | 20606533 |
| no association between endogenous retinoic acid and human papillomavirus clearance or incident cervical lesions in brazilian women. | although oncogenic human papillomavirus (hpv) infections have been established as the necessary cause of cervical cancer, most hpv infections are transient and rarely progress to squamous cervical lesions. the activity of hpv is tightly associated with epithelial cell differentiation; therefore, regulators of differentiation, such as retinoic acid (ra), have been considered targets for the prevention of hpv-associated squamous intraepithelial lesion (sil) development. the purpose of this study w ... | 2010 | 20606041 |
| are women with lupus at higher risk of hpv infection? | human papillomavirus (hpv) is the etiological agent of cervical cancer, the second most prevalent neoplasia among women. although it has been proven that systemic lupus erythematosus (sle) patients have higher frequency of cervical dysplasia, few studies have focused on hpv prevalence among them. this study aimed to investigate hpv prevalence among sle patients and to evaluate associated risk factors, including the use of immunosuppressors (im). total dna extracted from cervical samples of 173 s ... | 2010 | 20605875 |
| human papillomavirus-like particles vaccine efficiently produced in a non-fermentative system based on insect larva. | 2010 | 20600940 | |
| corrigendum to "the potential cost-effectiveness of adding a human papillomavirus vaccine to the cervical cancer screening programme in south africa" [vaccine 27 (2009) 6196-6202]. | 2010 | 20600485 | |
| laryngeal squamous cell carcinoma in a 13 year-old child associated with human papillomaviruses 16 and 18: a case report and review of the literature. | squamous cell carcinoma (scc) of the larynx is extremely rare in adolescents and typically has an aggressive nature. the mechanism of laryngeal oncogenesis is complex and little is known about the role that human papillomavirus (hpv) plays in scc in adolescents. we report a case of invasive laryngeal scc that co-expressed hpv dna subtypes 16 and 18 in a 13 year-old boy. detection of hpv dna types 6, 11, 16, 18, 31, 33, and 51 was performed by in situ hybridization, with confirmation by polymeras ... | 2009 | 20596987 |
| papillomas of the external ear canal: report of ten cases in chinese patients with hpv in situ hybridization. | squamous papilloma is a benign exophytic proliferation which can occur occasionally in the external ear canal. it is widely assumed that the human papilloma virus (hpv) is an etiologic factor of papillomas. available techniques for detection of hpv genomes include immunohistochemistry, southern blot hybridization, in situ hybridization (ish), and polymerase chain reaction. to our knowledge, hpv typing has not been reported on tissue sections of papillomas in the external ear canal. we report hpv ... | 2009 | 20596973 |
| hpv-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome. | human papilloma virus (hpv) is an etiologic agent in a subset of oropharyngeal squamous cell carcinomas (sccs). the aim of this study was to sub-classify scc of the oropharynx based upon histologic features into nonkeratinizing (nk) scc, keratinizing (k) scc, and hybrid scc, and determine the frequency of hpv and patient survival in each group. patients with oropharyngeal scc with a minimum of 2 years of clinical follow-up were identified from radiation oncology databases from 1997 to 2004. all ... | 2009 | 20596971 |
| influence of hpv16 e2 and its localisation on the expression of matrix metalloproteinase-9. | infection with the high-risk hpv types 16 and 18 is the major cause of cervical cancer and plays a role in the development of certain head and neck and skin cancers. we have previously demonstrated that the early protein 2 of the cottontail rabbit papillomavirus (crpv), required for skin carcinogenesis in a rabbit model, is able to induce the expression of a matrix metalloproteinase (mmp-9); a protease known to play a key role in invasion and metastasis. however, as of now we do not understand t ... | 2010 | 20596661 |
| atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion: review of ancillary testing modalities and implications for follow-up. | to review the cytology category atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (asc-h), with human papillomavirus (hpv) and other ancillary testing results and according to age group. | 2010 | 20592556 |
| accuracy and cost-effectiveness of cervical cancer screening by high-risk human papillomavirus dna testing of self-collected vaginal samples. | estimate the accuracy and cost-effectiveness of cervical cancer screening strategies based on high-risk human papillomavirus (hpv) dna testing of self-collected vaginal samples. | 2010 | 20592553 |
| ec3--a modern telecommunications matrix for cervical cancer prevention in zambia. | low physician density, undercapacitated laboratory infrastructures, and limited resources are major limitations to the development and implementation of widely accessible cervical cancer prevention programs in sub-saharan africa. | 2010 | 20592550 |
| e6ap ubiquitin ligase mediates ubiquitin-dependent degradation of peroxiredoxin 1. | e6-associated protein (e6ap) is a cellular ubiquitin protein ligase that mediates ubiquitylation and degradation of tumor suppressor p53 in conjunction with the high-risk human papillomavirus e6 protein. we previously reported that e6ap targets annexin a1 protein for ubiquitin-dependent proteasomal degradation. to gain a better understanding of the physiological function of e6ap, we have been seeking to identify novel substrates of e6ap. here, we identified peroxiredoxin 1 (prx1) as a novel e6ap ... | 2010 | 20589759 |
| hpv vaccination: vaccine acceptance, side effects and screening intentions. | as part of an evaluation of the introductory campaign of human papilloma virus (hpv) vaccine in a scottish health board, self-administered questionnaires were offered to all 5007 eligible girls in school following the third dose of hpv to identify side-effects, reasons for non-vaccination and future cervical screening intentions, and 2775 (56.2%) replied. in all, 630 (23.5%) of vaccinated girls reported side effects to the vaccination, about half of which were common injection-site reactions. ma ... | 2010 | 20586376 |
| the hpv vaccination strategy: could male vaccination have a significant impact? | we investigate the potential success of the human papilloma virus (hpv) vaccine, taking into consideration possible waning immunity and the influence of behavioural parameters. we use a compartmental, population-level ordinary differential equation (ode) model. we find the effective reproductive value for hpv, re0, which measures the threshold for infection outbreak in a population that is not entirely susceptible, together with infection prevalence. we study the effects of different parameters ... | 2010 | 20582762 |
| association between physician specialty and uptake of new medical technologies: hpv tests in florida medicaid. | it is well established that specialists often adopt new medical technologies earlier than generalists, and that racial and ethnic minority patients are less likely than white patients to receive many procedures and prescription drugs. however, little is known about the role that specialists or generalists may play in reducing racial and ethnic disparities in uptake of new medical technologies. human papillomavirus (hpv) dna tests, introduced as a cervical cancer screening tool in 2000, present a ... | 2010 | 20582485 |
| correlation between hybrid capture ii high-risk human papillomavirus dna test chemiluminescence intensity from cervical samples with follow-up histologic results: a cytologic/histologic review of 367 cases. | the hybrid capture ii high-risk human papillomavirus (hrhpv) dna test is a us food and drug administration-approved nucleic acid hybridization assay using chemiluminescence for the semiquantitative detection of hrhpv in cervical samples. patient samples and controls are used to calculate results as negative for hrhpv if <1.0, positive for hrhpv if >2.5, and "equivocal" if between 1.0 and 2.5. | 2010 | 20578088 |
| who policy development processes for a new vaccine: case study of malaria vaccines. | recommendations from the world health organization (who) are crucial to inform developing country decisions to use, or not, a new intervention. this article analysed the who policy development process to predict its course for a malaria vaccine. | 2010 | 20576114 |
| safety and immunogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine in hiv-infected children 7 to 12 years old. | quadrivalent human papillomavirus vaccine (qhpv) is > 95% effective in preventing infection with vaccine-type human papillomavirus. the safety and immunogenicity of qhpv are unknown in hiv-infected children. | 2010 | 20574412 |
| characterization of human papillomavirus infection in north taiwan. | the detection of human papillomavirus (hpv) is very important for the evaluation of preventative strategies for cervical cancer. the major objective of this study was to characterize the prevalence of different genotypes of hpv in north taiwan to contribute to the epidemiological knowledge of hpv infections. papanicolaou (pap) cervical smears were collected from 10,543 women aged between 14 and 87 years. the polymerase chain reaction (pcr) and dna array hybridization techniques were used to geno ... | 2010 | 20572075 |
| a case study: lessons learned from human papillomavirus vaccine development: approval of a vaccine for use in children and young adolescents for prevention of an adult disease. | this article presents the adolescent clinical trials program for the quadrivalent hpv vaccine (merck and co, inc, whitehouse station, nj) as a case study of the development of a preventive intervention for use in young adolescents to protect against a future sexually transmitted infection and its associated diseases. in light of similarities in human papillomavirus (hpv) and hiv with regard to sexual transmission and the associated social and ethical issues related to prevention trial developmen ... | 2010 | 20571424 |
| trends in cervical cancer incidence and mortality in the baltic countries, bulgaria and romania. | the burden of cervical cancer varies considerably in the european union (eu). in this article, we describe trends in incidence of and mortality from this cancer in the two most affected areas: the baltic countries (estonia, latvia and lithuania) and southeast europe (bulgaria and romania). incidence data were obtained from the national cancer registries. data on population and number of deaths from uterine cancers were extracted from the world health organization mortality database. mortality ra ... | 2011 | 20568103 |
| [progress in the world and challenges in japan on hpv vaccination for cervical cancer prevention]. | for cervical cancer prevention, cervarix(hpv-16/18)was approvedin japan andvaccination programs against hpv-16/18 were startedin december, 2009. this vaccine is almost 100% effective in preventing high-grade precancer associated with the hpv types; it is safe and well tolerated. in japan, universal vaccination of females between 11 and 14 years is recommended. we all look forward to eradicating cervical cancer in the not too distant future. | 2010 | 20567096 |
| cigarette smoke condensate induces nuclear factor kappa-b activity and proangiogenic growth factors in aerodigestive cells. | aerodigestive cancer risk of both lung and head and neck cancers has been linked to the genotoxic effects of tobacco use. these effects include upregulation of nuclear factor kappa-b (nfkappab) and its downstream products associated with both lung and head and neck cancer malignant progression. | 2010 | 20564670 |
| primary squamous cell carcinoma of the endometrium. | a rare case of primary squamous cell carcinoma of the endometrium, probably originating from adenomyosis, is presented. a 58-year-old japanese woman was referred to kitasato institution medical center hospital to explore the cause of her postmenopausal bleeding. the endometrial cytology specimen obtained with the endocyte (an device for endometrial check up) showed cells suggesting well differentiated squamous cell carcinoma. the patient underwent modified radical hysterectomy, bilateral salping ... | 2000 | 20563701 |
| genotype-specific persistence of genital human papillomavirus (hpv) infections in women followed for 6 years in the finnish family hpv study. | persistent human papillomavirus (hpv) infection is the most important risk factor for cervical cancer, and understanding genotype-specific hpv persistence is essential for elucidating the natural history of hpv infections. | 2010 | 20557239 |
| perinatal outcomes in condyloma acuminata pregnancies. | to investigate pregnancy outcome in patients with condyloma acuminata. | 2011 | 20556405 |
| mucosal delivery of human papillomavirus pseudovirus-encapsidated plasmids improves the potency of dna vaccination. | mucosal immunization may be important for protection against pathogens whose transmission and pathogenesis target the mucosal tissue. the capsid proteins of human papillomavirus (hpv) confer tropism for the basal epithelium and can encapsidate dna during self-assembly to form pseudovirions (psvs). therefore, we produced mucosal vaccine vectors by hpv psv encapsidation of dna plasmids expressing an experimental antigen derived from the m and m2 proteins of respiratory syncytial virus (rsv). intra ... | 2010 | 20555315 |
| high-throughput profiling of the humoral immune responses against thirteen human papillomavirus types by proteome microarrays. | we have developed microarrays with all eight proteins encoded by 13 different human papillomavirus types associated with anogenital cancer (hpv-16, -18, -31, -33, -35, -45, and -53), genital warts (hpv-6 and -11), or skin lesions (hpv-1, -2, -4, and -5). we analyzed the seroprevalence of antibodies in 546 patients, which had either cervical carcinomas, or precursor lesions, or which were asymptomatic. all patient groups contained sera ranging from high reactivity against multiple hpv proteins to ... | 2010 | 20554302 |
| interaction of viral oncoproteins with cellular target molecules: infection with high-risk vs low-risk human papillomaviruses. | persistent infection by a subgroup of so-called high-risk human papillomaviruses (hpvs) that have a tropism for mucosal epithelia has been defined as the cause of more than 98% of cervical carcinomas as well as a high proportion of other cancers of the anogenital region. infection of squamous epithelial tissues in the head and neck region by these same high-risk hpvs is also associated with a subset of cancers. despite the general conservation of genetic structure amongst all hpv types, infectio ... | 2010 | 20553529 |
| the natural history of human papillomavirus infections of the mucosal epithelia. | human papillomaviruses (hpvs), members of a very large family of small dna viruses, cause both benign papillomas and malignant tumors. while most research on these viruses over the past 30 years has focused on their oncogenic properties in the genital tract, they also play an important role in diseases of the upper aerodigestive tract. rapidly accelerating advances in knowledge have increased our understanding of the biology of these viruses and this knowledge, in turn, is being applied to new a ... | 2010 | 20553526 |
| cervical cancer screening with both human papillomavirus and papanicolaou testing vs papanicolaou testing alone: what screening intervals are physicians recommending? | guidelines recommend screening for cervical cancer among women 30 years or older 3 years after a normal papanicolaou test (hereinafter referred to as pap test) result or a combined normal screening result (normal pap/negative human papillomavirus [hpv] test results). we assessed reported recommendations by us primary care physicians (pcps) on screening intervals that incorporate hpv cotesting compared with pap testing alone. | 2010 | 20548011 |
| success or failure of vaccination for hpv16-positive vulvar lesions correlates with kinetics and phenotype of induced t-cell responses. | one half of a group of 20 patients with human papillomavirus type 16 (hpv16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (cr) after therapeutic vaccination with hpv16 e6/e7 synthetic long peptides. patients with relatively larger lesions generally did not display a cr. to investigate immune correlates of treatment failure, patients were grouped according to median lesion size at study entry, and hpv16-specific immunity was analyzed at different time points by ... | 2010 | 20547850 |
| human papillomavirus vaccination of males: attitudes and perceptions of physicians who vaccinate females. | we assessed u.s. physicians' attitudes and perceptions regarding potential human papillomavirus (hpv) vaccination of males. | 2010 | 20547286 |
| recurrent respiratory papillomatosis with malignant transformation. | 2010 | 20546542 | |
| p16(ink4a) is superior to high-risk human papillomavirus testing in cervical cytology for the prediction of underlying high-grade dysplasia. | the primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (icc) assay for p16(ink4a) to high-risk (hr) human papillomavirus (hpv) detection by polymerase chain reaction (pcr) as diagnostic adjuncts for cytology specimens from colposcopy patients. | 2010 | 20544710 |
| male circumcision to reduce sexual transmission of hiv. | three large trials among african heterosexual men in the last decade have confirmed that male circumcision reduces hiv acquisition. this review summarizes recent data regarding circumcision performed primarily to reduce hiv in high-prevalence settings. | 2010 | 20543611 |
| external quality assessment for molecular detection of human papillomaviruses. | the united kingdom national external quality assessment service (uk neqas) distributes clinically relevant and educational specimens for external quality assessment (eqa). | 2010 | 20542463 |
| the isg15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of isg15. | isg15 is an interferon-induced and antiviral ubiquitin-like protein (ubl). herc5, the major e3 enzyme for isg15, mediates the isgylation of more than 300 proteins in interferon-stimulated cells. in addressing this broad substrate selectivity of herc5, we found that: (1) the range of substrates extends even further and includes many exogenously expressed foreign proteins, (2) isg15 conjugation is restricted to newly synthesized pools of proteins, and (3) herc5 is physically associated with polyri ... | 2010 | 20542004 |
| carrageenan as an adjuvant to enhance peptide-based vaccine potency. | new innovative therapies are urgently required in order to combat the high mortality and morbidity associated with advanced cancers. antigen-specific cancer immunotherapy using peptide-based vaccination has emerged as an attractive approach for the control of cancers due to its simplicity and easy preparation. however, such an approach requires the employment of suitable adjuvants. in the current study, we explored the employment of a sulfated polysaccharide compound from red algae, carrageenan ... | 2010 | 20541583 |
| acr appropriateness criteria: local-regional therapy for resectable oropharyngeal squamous cell carcinomas. | the optimal management of resectable oropharyngeal squamous cell carcinomas is controversial with many treatment options, both surgical and nonsurgical approaches, supported by published experiences with no randomized trials comparing commonly accepted treatments. the treatment decisions are further complicated by the need for local-regional disease control and competing goals to preserve salivary and swallow function. treatment decisions may also be affected by tumor and patient related factors ... | 2010 | 20541056 |
| relationships between epidermal growth factor receptor expression and human papillomavirus status as markers of prognosis in oropharyngeal cancer. | this study examines the prognostic significance of epidermal growth factor receptor (egfr) expression in relation to human papillomavirus (hpv) status in oropharyngeal squamous cell carcinoma (scc). | 2010 | 20537890 |
| perianal bowen disease in a child with human immunodeficiency virus. | individuals infected with the human immunodeficiency virus (hiv) are at increased risk for human papillomavirus (hpv)-related cancers of the anogenital region. a majority of these cancers have been reported in adult patients; few reports are available regarding anogenital hpv-associated carcinomas developing in children. we report a case of perianal bowen disease in an hiv-positive child. an 8-year-old hiv-positive boy with a history of perianal verrucous lesions presented to a clinic in lesotho ... | 2010 | 20537068 |
| htert promoter activity and cpg methylation in hpv-induced carcinogenesis. | activation of telomerase resulting from deregulated htert expression is a key event during high-risk human papillomavirus (hrhpv)-induced cervical carcinogenesis. in the present study we examined htert promoter activity and its relation to dna methylation as one of the potential mechanisms underlying deregulated htert transcription in hrhpv-transformed cells. | 2010 | 20534141 |
| who should get the hpv vaccine? usage expands amid debate. | 2010 | 20530765 | |
| e6-associated protein is required for human papillomavirus type 16 e6 to cause cervical cancer in mice. | high-risk human papillomaviruses (hpv) cause certain anogenital and head and neck cancers. e6, one of three potent hpv oncogenes that contribute to the development of these malignancies, is a multifunctional protein with many biochemical activities. among these activities are its ability to bind and inactivate the cellular tumor suppressor p53, induce expression of telomerase, and bind to various other proteins, including bak, e6bp1, and e6tp1, and proteins that contain pdz domains, such as hscr ... | 2010 | 20530688 |
| hpv16 e2 is an immediate early marker of viral infection, preceding e7 expression in precursor structures of cervical carcinoma. | the viral e2 gene product plays a crucial role in the human papillomavirus (hpv) vegetative cycle by regulating both transcription and replication of the viral genome. e2 is a transcriptional repressor of the e6 and e7 viral oncogenes for hpv types 16 and 18, which are involved in cervical cancers. using new polyclonal antibodies against the hpv16 e2 protein, we showed that e2 is expressed at various precursor stages of cervical carcinoma by immunohistochemistry on paraffin-embedded clinical sam ... | 2010 | 20530671 |
| prevalence of human papillomavirus (hpv) in chinese patients with colorectal cancer. | abstract aim: the prevalence of human papillomavirus (hpv) was determined in chinese patients with colorectal cancer (crc). the study also aimed to determine whether hpv dna peripheral blood assay can be used to diagnose hpv-related crc. method: tumor tissue, non-cancerous colorectal tissue and whole blood samples were obtained from 96 crc patients. in addition, 32 colorectal tissue samples were harvested from patients without crc and 48 whole blood samples were collected from healthy blood dono ... | 2010 | 20528894 |
| assessment of the cost-effectiveness of a quadrivalent hpv vaccine in norway using a dynamic transmission model. | to assess the epidemiological and economic impact of alternative quadrivalent human papillomavirus (hpv) vaccine strategies in norway, we adapted a previously published dynamic transmission model. vaccination of girls and women aged 12-24 years reduced the incidence of hpv 6/11/16/18-related genital warts, cervical intraepithelial neoplasia and cervical cancer by 94, 92 and 92% by year 100, respectively. the cost-effectiveness ratio for this strategy when compared with vaccinating girls before t ... | 2008 | 20528334 |
| epidemiological modelling of risk factors of human papilloma virus in women with positive cytology in the county of csongrád. | this study was carried out to determine the prevalence and risk factors of genital hpv infection in women diagnosed with non-negative cytology in southeastern hungary. cervical samples were collected for cytology and hpv testing from women seen at gynaecological outpatient clinics and diagnosed with non-negative cytology. the observed overall average hpv infection rate was found to be 61%. a smoking habit was the only risk factor in the logistic regression analysis that related significantly to ... | 2010 | 20527236 |
| the effects of genital schistosoma haematobium on human papillomavirus and the development of cervical neoplasia after five years in a zimbabwean population. | high-risk human papillomavirus (hpv) is responsible for cervical cancer and genital schistosoma haematobium infection has been hypothesized to be an additional co-factor or even an independent risk factor for cervical neoplasia. the present study aimed to investigate the impact of schistosomiasis on hpv persistence and development of cell atypia in a group of rural zimbabwean women with confirmed high-risk hpv. | 2010 | 20527233 |
| commentary: clinical nodal staging of human papillomavirus-related oropharyngeal cancer. | 2010 | 20526107 | |
| interleukin-10 production by tumor infiltrating macrophages plays a role in human papillomavirus 16 tumor growth. | human papillomavirus, hpv, is the main etiological factor for cervical cancer. different studies show that in women infected with hpv there is a positive correlation between lesion grade and number of infiltrating macrophages, as well as with il-10 higher expression. using a hpv16 associated tumor model in mice, tc-1, our laboratory has demonstrated that tumor infiltrating macrophages are m2-like, induce t cell regulatory phenotype and play an important role in tumor growth. m2 macrophages secre ... | 2010 | 20525400 |
| p53 codon 72 and p21 codon 31 polymorphisms and susceptibility to cervical adenocarcinoma in korean women. | the aims of this study were to evaluate the genotype frequencies of p53 codon 72 and p21 codon 31 in cervical adenocarcinoma patients and controls, and the association between the specific genotype or genotype combination of these polymorphisms and the risk of cervical adenocarcinoma in korean women. genotyping was performed using dna from cervical biopsy specimens collected from 53 patients with cervical adenocarcinoma, of whom 34 were hpv 16 or 18 positive, and from the cervical exfoliated cel ... | 2010 | 20524403 |
| an infant presenting with a voluminous exophytic perineal mass. | 2010 | 20524229 | |
| age-specific hpv seroprevalence among young females in the netherlands. | to obtain insight into the age-specific seroprevalence for human papillomavirus (hpv) 6, 11, 16 and 18 among females before introduction of hpv vaccination in the netherlands. | 2010 | 20519252 |
| awareness and knowledge about human papillomavirus among inuit women in nunavik, quebec. | accurate knowledge about human papillomavirus (hpv) and its link to cervical cancer is essential for women to understand and make use of cervical cancer prevention and detection opportunities. this study was the first to survey awareness and knowledge of hpv in a population of canadian inuit. the objectives of this study were to assess the level of awareness and knowledge of inuit women in nunavik, quebec, canada, about hpv infection and its relation to cervical cancer and to study correlates of ... | 2011 | 20517640 |
| polymorphism of the capsid l1 gene of human papillomavirus types 31, 33, and 35. | the l1 gene encodes for the major capsid protein of human papillomaviruses (hpv). there is limited information on the polymorphism of l1 for types related to hpv-16. this report explores the polymorphism of l1 in phylogenetically related types 31, 33, and 35 compared to hpv-16. genital specimens collected from 732 hiv-seropositive and 323 hiv-seronegative women were screened for hpv dna with consensus l1 pcr. cervical samples positive for hpv-16 (n = 74), hpv-31 (n = 78), hpv-33 (n = 37), and hp ... | 2010 | 20513080 |
| adult women's attitudes toward the hpv vaccine. | two human papillomavirus (hpv) vaccines have demonstrated efficacy in preventing hpv infection and are currently being administered to adolescent girls in several countries. although the most efficient hpv prevention strategy is immunizing adolescents before there is any risk of exposure, adult women also may benefit from vaccination. this study aimed to explore the attitudes of women aged 27-55 years toward the hpv vaccine. | 2010 | 20509785 |
| efficacy of hpv 16/18 vaccines on sexually active young women and the impact on organized cervical cancer screening. | 2010 | 20504086 | |
| immortalization of oral keratinocytes by functional inactivation of the p53 and prb pathways. | a subgroup of head and neck squamous cell carcinomas (hnsccs) contains high-risk human papillomavirus-type 16 (hpv16). the viral e6 and e7 oncoproteins inactivate the p53 and prb proteins, respectively. we examined the causative effect of hpv16 e6 and e7 expression on the immortalization of normal oral keratinocytes (okcs) and compared the resulting phenotype with alternative ways of p53- and prb-pathway abrogation frequently found in hnsccs without hpv. primary okcs were conditionally immortali ... | 2011 | 20499310 |