Publications

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infectivity of ancylostoma caninum larvae from canine milk. 19705469538
influence of fertilization on ovogenesis in ancylostoma caninum. 19705461090
biochemistry of the dog hookworm. ii. nature and origin of the excreted fatty acids. 19705419452
effect of ingested garlic on necator americanus and ancylostoma caninum. 19695389769
ancylostoma caninum burden in relationship to erythrocyte loss in dogs. 19695361272
nature of an anticoagulant from the cephalic glands of ancylostoma caninum. 19665332833
blood loss during hookworm infection determined by erythrocyte labeling with radioactive 51-chromium. i. infection of dogs with normal and with x-irradiated ancylostoma caninum. 19665297075
some observations on experimental infection of cyclops with ancylostoma caninum larvae. 19715159146
ancylostoma caninum: pharyngeal activity in vitro. 19715145806
experimental ancylostoma caninum infection in dogs. 19715144155
in vitro action of tetramisole on the development of ancylostoma caninum. 19715143160
inhibition of development of ancylostoma caninum with tetramisole. 19715107113
effect of dichlorvos on eggs and larvae of ancylostoma caninum. 19715104315
anticoagulant activity of dog hookworm. 19715102508
helminths of cats from the midwest with a report of ancylostoma caninum in this host. 19715090968
ocular nematodiasis: results with ancylostoma caninum in mice. 19725042072
histochemical studies of the skin and intestine of dogs infected with ancylostoma caninum larvae. 19725038421
studies in ancylostoma caninum infection in dogs. ii. anatomical changes in the gastrointestinal tract. 19725038245
the effects of ancylostoma caninum on the liver and lung of mice as shown by histochemical techniques. 19725035194
experimental infection of cyclops with the larvae of ancylostoma caninum. 19725035192
studies in ancylostoma caninum infection in dogs. i. absorbtion from the small intestine of amino-acids, carbohydrates and fat. 19725021561
fine structure of the intestine of the nematodes, ancylostoma caninum and phocanema decipiens. 19684915918
ancylostoma caninum: intestinal pigment granules. 19704911146
attachment and feeding behavior of ancylostoma caninum. 19704908335
early stage of infection of ancylostoma caninum in dogs and mice. 19734752378
efficacy of a hookworm (ancylostoma caninum) vaccine for dogs. 19734721752
[studies on the possibility of prenatal and galactogenic infections with ancylostoma caninum ercolani 1859 (ancylostomidae) in the dog]. 19734693427
protective immunity against ancylostoma caninum in dogs vaccinated with free-living soil nematodes. 19734683965
in vitro action of normal and immune sera on the larval and adult stages of ancylostoma caninum. 19724676816
scanning electron microscopy of hookworms. 1. morphological differences between infective stages of ancylostoma caninum (ercolani, 1859) and ancylostoma tubaeforme (zeder, 1800). 19744458075
biochemistry of the dog hookworm. 3. oxidative phosphorylation. 19704315908
intestinal trauma resulting from feeding activities of ancylostoma caninum. 19744139902
ancylostoma caninum: analysis of antigens of the canine hookworm. 19704100984
differences in lipid granulation as the basis for a morphologic differentiation between third-stage larvae of uncinaria stenocephala and ancylostoma caninum.differences in the distribution of lipid granules between unstained third-stage larvae of uncinaria stenocephala and ancylostoma caninum cultured at 15 c was found to be an effective means for differentiating these 2 species of canine hookworms. in contrast, larvae cultured at 22 c were less easily differentiated based on the distribution of lipid granules. after culturing at 15 c, third-stage larvae of u. stenocephala were motile and exhibited 32 well-demarcated intestinal cells which contained ...19854093808
the efficacy of some newer broad spectrum anthelmintics against third-stage larvae of ancylostoma caninum in the mouse.the efficacy of eight anthelmintics against ancylostoma caninum larvae in the skeletal muscles of mice was evaluated. levamisole (5 x 40 mg/kg), thiabendazole (5 x 400 mg/kg), oxfendazole (5 x 100 mg/kg), albendazole (5 x 100 mg/kg), flubendazole (5 x 200 mg/kg), benacil (5 x 200 mg/kg) and phenacizole (5 x 200 mg/kg) showed marked larvicidal activity (98 to 99%). sch 18099 did not show larvicidal activity even at 5 x 400 mg/kg.19854093589
experimental infection of pups with ancylostoma caninum larvae from an abnormal host, the chicken.the migration and distribution of ancylostoma caninum larvae in the tissues of chickens, infected orally with 1,000 larvae, were studied. larval yield at necropsy from different organs after digestion with artificial gastric juice revealed a 62.9% recovery four hours after inoculation, followed by a sharp decline to 5.4% at 72 hours. larvae were found in the heart within four hours, the lungs within eight hours and the liver within 12 to 18 hours but no larvae were recovered from the spleen, kid ...19854093588
prenatal and lactational transmission of toxocara canis and ancylostoma caninum: experimental infection of the bitch at midpregnancy and at parturition. 19854066142
experimental infection of pups with ancylostoma caninum-infected mouse tissues.migration and distribution of ancylostoma caninum larvae in the tissues of mice orally infected with 1000 larvae, and establishment of patent infection from the mice to the definitive host, were studied. larval yield from different organs of mice, after digestion with artificial gastric juice, indicated that the highest recovery was at 4 h post-infection (62.8%), and thereafter a slight decline occurred up until 30 days post-infection (51.5%). migration of larvae to the lungs occurred within 4 h ...19854049727
temperature-induced separation of larvae of uncinaria stenocephala from a mixed fecal culture containing ancylostoma caninum. 19854040166
anthelmintic efficacy of febantel combined with praziquantel in dogs.ninety-four dogs were randomly assigned to 1 of 6 groups (5 treated and 1 untreated control) for evaluation of anthelmintic efficacy. three anthelmintic formulations were studied: a febantel paste, a praziquantel paste, and a combination paste containing both active ingredients. treated dogs were dosed once daily for 3 days. the minimal effective dosages in combination were established as 10 mg of febantel and 1 mg of praziquantel/kg of body weight. at those dosages for the combination, 99.5% to ...19854030460
chemotactic attraction of infective hookworm larvae of ancylostoma caninum by a dog serum factor.infective hookworm larvae of ancylostoma caninum showed chemotaxis on agar plates in a dog serum gradient. this chemotactic behaviour remain unaltered using an ultrafiltrated serum fraction with a molecular weight less than 500. gelfiltration of this ultrafiltrated fraction revealed a factor with a molecular weight of 480 causing chemotaxis. the chemotactic activity of the factor was destroyed after a pronase treatment. we conclude that the factor could be a polypeptide.19854024709
prenatal and lactational transmission of toxocara canis and ancylostoma caninum: experimental infection of the bitch before pregnancy. 19853980144
specific antibody responses in dogs experimentally infected with echinococcus granulosus.six dogs reared helminth-free were divided into 2 groups. four dogs were infected per os with 200,000 protoscoleces each of echinococcus granulosus and 2 were kept as uninfected controls. all the dogs were kept together until 32 days after infection, when 1 infected dog was killed, its intestine removed and the contents examined to confirm that the infection with e. granulosus had been successful. the remaining 3 infected dogs were transferred to high security housing and their feces inspected d ...19863953947
isolation and characterization of a proteolytic enzyme from the adult hookworm ancylostoma caninum.the adult hookworm ancylostoma caninum releases a proteolytic enzyme which is thought to be essential for its adaption to parasitism. the protease was purified from parasite extracts by ion-exchange chromatography followed by gel filtration and hydrophobic interaction chromatography. the purified enzyme exhibited a molecular weight of 37,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis and had an nh2-terminal sequence of arg-his-his-gln-pro-lys-val-ala-leu-leu-gly-ala-his-gly-gly ...19853888998
comparative studies on the infestation of three different breeds of dogs by gastro-intestinal helminths.the findings of an investigation mounted to evaluate and compare the prevalence of parasitic gastro-intestinal helminth ova in three different breeds of dogs in calabar, nigeria are presented. results of the investigation indicate that in alsatians, 25% infestation with strongyloides stercoralis, 25% toxocara canis, 65% ancylostoma caninum were found, in crossbreed between alsatian and mongrel, 15.56% infestation with strongyloides stercoralis, 10.93% toxascaris leonina, 25% toxocara canis, 68.7 ...19853869810
studies on the prevalence of gastro-intestinal helminths of dogs in calabar, nigeria.the results of investigational study to determine the prevalence of gastro-intestinal helminths of dogs in calabar, nigeria with particular emphasis on the effects of sex and age of the animals on the occurrence of these endoparasites are presented. of a total of 254 dogs sampled using saturated brime solution floatation method and formalin-ether sedimentation method, 223 (86.97%) were infected. a breakdown of the number of parasitized dogs shows that 180 (70.86%) were positive for ancylostoma c ...19853869127
dose-titration studies of ivermectin against experimental ancylostoma caninum and uncinaria stenocephala infections.dose-titration trials of ivermectin were conducted on pups with dual experimental infections of 4th-stage larvae or adult ancylostoma caninum and uncinaria stenocephala. ivermectin was administered orally or subcutaneously at dosages of 0.006, 0.012, or 0.024 mg/kg of body weight. maximal or near maximal (greater than or equal to 96% to 100%) anthelmintic effect was observed for both stages of development for each hookworm species by either route of administration at a dosage of 0.024 mg/kg. res ...19853839115
experimental infection of ancylostoma caninum in chickens: immunization through transfer of sensitized bursal cells.an attempt has been made to demonstrate the immune response in chickens to infection by the dog hookworm ancylostoma caninum following transfer of sensitized bursal cells from infected donor chickens. recipients were challenged with a dose of 500 larvae each, 1, 3 and 5 days after cell transfer. the immune response was found to be more pronounced in recipients challenged 5 days after cell transfer than in those challenged 1 or 3 days after transfer and those which received non-sensitized bursal ...19863805714
the prevalence of parasitic helminths in stray dogs in the baghdad area, iraq.the prevalence of parasitic helminths in 20 stray dogs from the area of baghdad was recorded. taenia spp. were found in 12 dogs, dipylidium caninum in ten dogs, toxocara canis in eight dogs, ancylostoma caninum in seven dogs and echinococcus granulosus in five dogs. spirocerca lupi and dirofilaria immitis were found in three dogs, mesocestoides lineatus in two dogs and strongyloides stercoralis in one dog.19863800471
[method of the spread of larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) in the definitive host (beagle)]. 19863751391
the origin and some of the functions of smooth endoplasmic reticulum in ancylostoma caninum sperm cells. 19863744670
serum levels of aspartate transaminase, alanine transaminase and worm burden in mice infected with ancylostoma caninum larvae.aspartate transaminase and alanine transaminase levels showed considerable increase during initial (1 to 9 days) period of infection in all the experimental groups of mice and their level reached higher values than in the controls. the increase of enzymes was influenced by the degree of retention of worm load and the immunological damage caused by ancylostoma caninum larvae within the host system.19863721359
the response of captive rodents to the migration of ancylostoma caninum larvae.the distribution of the larvae of ancylostoma caninum in tissues of captive wild rodents (rattus rattus) and the leucocytic and behavioural responses of these rodents were studied after experimental oral infection. there was a wide distribution of larvae in tissues with a preponderance of the larvae in the skeletal muscles of the anterior part of the body in older infection. the rats responded by an elevation of total leucocytes and eosinophils in blood, alternation of locomotory activity and be ...19863721358
efficacy of benzimidazoles against larval ancylostoma caninum infection in mice. 19863721357
parasites of stray dogs in the rabat region, morocco.eighteen parasites were identified from 57 stray dogs from the urban and rural areas of rabat. the prevalence of the species of parasites was: ctenocephalides (c. canis, c. felis) 94.7%, rhipicephalus sanguineus 68.5%, linguatula serrata, babesia canis, isospora canis each 3.5%, toxocara canis 7%, dirofilaria immitis, taenia hydatigena, t. pisiformis each 12.3%, dipetalonema dracunculoides 10.5%, ancylostoma caninum 17.5% echinococcus granulosus 22.8%, toxascaris leonina 33.3%, dipylidium caninu ...19873675044
[effects of various anti-hookworm drugs on the cholinesterase activity of necator americanus, ancylostoma duodenale, ancylostoma caninum and nippostrongylus braziliensis]. 19873621504
[the effect of fenbendazole on resting somatic larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) in the pregnant bitch]. 19873591107
helminth parasites of the coyote (canis latrans) in tennessee.from 1980 to 1984, 267 coyotes (canis latrans) from tennessee were examined for helminth parasites. hearts were examined for the presence of dirofilaria immitis, diaphragms for trichinella spiralis, and digestive tracts for other helminths. six species were found including 5 nematodes (d. immitis, physaloptera rara, trichuris vulpis, ancylostoma caninum, and toxascaris leonina) and 1 cestode (taenia pisiformis). univariate and multivariate statistical techniques were used to assess parasite prev ...19873585628
maternal transmission by alaria marcianae (trematoda) and the concept of amphiparatenesis.the term amphiparatenic host was coined originally for hosts of alaria marcianae that as adults are paratenic hosts, but as juveniles serve as definitive hosts. in this study the concept of amphiparatenesis is placed in a theoretical context, maternal transmission shown to be the basic mechanism, and the concept extended to include toxocara canis, t. cati, t. pteropodis, neoascaris vitulorum, ancylostoma caninum, uncinaria lucasi, various species of strongyloides, pharyngostomoides procyonis, an ...19873572644
transmission of ancylostoma caninum and alaria marcianae in coyotes (canis latrans).one of seven female coyotes (canis latrans) captured in webb county, texas during september 1986 and confined and mated in holding facilities at millville, utah whelped the following spring. the maternal female (greater than 5-yr-old) and her five neonates were killed at 22 days postparturition. all were infected with adult ancylostoma caninum and were passing eggs in their feces. also, the neonates and maternal female were infected with immature and adult alaria marcianae, respectively. these f ...19883411716
efficacy of various anthelmintics against third-stage larvae of ancylostoma caninum in the brain of mice.in an experimental larval infection of ancylostoma caninum in mice, the efficacy of various anthelmintics against the larvae migrated and established in the brain is reported for the first time. albendazole and flubendazole were the most effective drugs. thiabendazole, benacil, phenacizole, oxfendazole and mebendazole showed significant larvicidal activity. tetramisole, levamisole, fenbendazole, sch 18099, pyrantel pamoate, morantel tartrate and oxantel pamoate did not show any significant activ ...19883372978
cell mediated immunity during experimental ancylostomiasis: a review.cell-mediated immunity is usually recognized only in a very small number of infections caused by helminths. the present review is engaged with some aspects of the cell-mediated immunity in infections caused by ancylostoma caninum. special attention is paid to the role of passive transfer of sensitized cells and serum. the paper is based on a series of own original investigations of the authors.19873323310
comparative histochemical studies of glycosidase activity in some helminths.comparative histochemical studies of glycosidase activity were carried out in clonorchis sinensis, eurytrema pancreaticum, fasciola hepatica, dipylidium caninum, hymenolepis nana, ascaris suum, toxocara canis, ancylostoma caninum, trichuris vulpis and dirofilaria immitis. the enzymes examined were: n-acetyl-beta-glucosaminidase (ec 3.2.1.30), beta-glucuronidase (ec 3.2.1.31) and beta-galactosidase (ec 3.2.1.23). there were variations in enzyme distribution and intensity among the species and als ...19863084622
comparison of immune response in swiss albino mice due to single and repeated doses of infective ancylostoma caninum larvae after subcutaneous inoculation.migratory behaviour of ancylostoma caninum larvae and host responses were studied in four groups of swiss albino mice infected subcutaneously with single doses of 1,000, 2,000 and multiple doses of 500 + 500, 500 + 500 + 1,000. after the 1st day most of the larvae found in muscles in all the groups. there is no significant difference in the migratory behaviour and/or the adoptive pattern of larvae in both the singly and multiply infected animals.19892809186
musca domestica as a carrier of intestinal helminths in calabar, nigeria.a study was undertaken to examine the role of musca domestica as a carrier of intestinal helminths in calabar, nigeria. a total of 5000 house-flies were collected from markets and residential areas and examined for helminthic parasites using centrifugation, dissection and direct smear methods. four helminths were observed with the following frequency of infection on their external surfaces and gastrointestinal tracts respectively: ascaris lumbricoides ova (0.20% and 0.81%), strongyloides stercor ...19892791934
[the effect of ivermectin on reactivated somatic larva of ancylostoma caninum ercolani 1859 (ancylostomidae) in the pregnant dog].it was evaluated by means of a controlled test to what extent reactivated larvae of ancylostoma caninum were influenced by single or double treatment with ivermectin. the investigations were done with a total of ten experimentally infected bitches. the single treatment of dams two to ten days ante partum with 0.5 mg or 1 mg ivermectin per kg bodyweight reduced the wormburden of their puppies on an average by 96.6% and 98.5%, respectively. the double treatment with 0.5 mg/kg bodyweight ante and p ...19892763759
a preliminary study on the use of enzyme-linked immunosorbent assay (elisa) for detection of trichinella spiralis infections in dogs.an enzyme-linked immunosorbent assay (elisa) was developed to detect trichinella spiralis infections in dogs using rabbit anti-canine igg-horseradish peroxidase prepared according to the improved periodate method and an antigen purified from t. spiralis larvae by sephadex g-200 chromatography. sixty-six canine sera were tested for trichinosis by the elisa and it showed a detection rate which was significantly higher than that by trichinoscopy. this antigen of t. spiralis appeared not to cross-re ...19892741302
efficacy of ivermectin in hookworms as examined in ancylostoma caninum infections.single oral doses of ivermectin were given to dogs with moderate or heavy infections of ancylostoma caninum (egg counts ranging from 7,100 to 41,700 eggs/g feces) at 100, 50, 30, or 10 micrograms/kg body weight. each of these dosages was effective in clearing the infection completely, so that numerous worms were passed in the feces on days 1-3, but no worm was recovered from the intestinal tract at necropsy on day 4 after treatment. in contrast, an average of 178 worms per dog was recovered at n ...19892723924
ancylostoma caninum in british greyhounds. 19892718327
a survey of helminths in domestic cats in the pretoria area of transvaal, republic of south africa. part 1: the prevalence and comparison of burdens of helminths in adult and juvenile cats.the helminths found in 1,502 necropsied cats were examined. the findings indicated that 65% of the cats were infested. the most prevalent helminths encountered were ancylostoma tubaeforme (41%), ancylostoma braziliense (25%), dipylidium caninum (23%), toxocara cati (11%), taenia taeniaeformis (7.7%), ancylostoma caninum (3.3%), joyeuxiella fuhrmanni (2.5%), ancylostoma ceylanicum (1.4%), and physaloptera praeputialis (1.3%). the following helminths were recorded in fewer than 1% of the cats: cen ...19892634770
enzymes activity and worm burden in intestine and liver of mice infected with single doses of ancylostoma caninum larvae.transaminases increased significantly in the intestine and liver of mice infected with 500, 1,000 and 2,000 doses of ancylostoma caninum larvae. the level of increase remained higher than those of controls throughout the experimental period. the rise of enzymes was mainly due to the pathological changes caused by the migrating larvae within the organs.19892625550
efficacy of nemadectin, a new broad-spectrum endectocide, against natural infections of canine gastrointestinal helminths.nemadectin, a new broad-spectrum endectocide, was highly efficacious against natural infections of all the major canine gastrointestinal helminths. at single oral dosages of 0.2-0.4 mg kg-1 body weight (bw), a liquid formulation administered in gelatin capsules was 100% effective in eliminating natural infections of toxocara canis, toxascaris leonina, ancylostoma caninum and uncinaria stenocephala. tablets (267 mg) containing 4.6% nemadectin given at a rate of 1/3 tablet per 20 kg bw (0.2 mg nem ...19892617829
serum enzymes and worm load in mice infected with repeated doses of ancylostoma caninum larvae.the alterations of serum enzymes induced in the host system of swiss albino mice by infection with ancylostoma caninum larvae have been studied in multiple doses of infection. it was found that the level of transaminases, alkaline phosphatase and amylase increased significantly throughout the infection period when compared with controls. in infected animals, increase of enzymes was influenced by the host-parasite interactions caused due to the retained concentration of larval antigens.19882457613
changes in serum enzyme activities in mice infected with single doses of ancylostoma caninum larvae.aspartate transaminase, alanine transaminase, alkaline phosphatase and amylase levels were significantly increased in experimental female swiss albino mice infected with single doses of 500, 1,000 and 2,000 larvae of ancylostoma caninum. increase of enzyme levels is due to the leakage of large amounts of enzymes into the blood. the necrosis of cells during intestinal and extra intestinal phases of ancylostomiasis in mice is directly responsible for the increase of enzymes.19872437181
specificity of scolex and oncosphere antigens for the serological diagnosis of taeniid cestode infections in dogs.groups of dogs raised free of helminths were monospecifically infected with the common nematodes toxocara canis, ancylostoma caninum and trichuris vulpis. serums from these dogs, and a group of dogs of unknown history but infected with dirofilaria immitis and dipylidium caninum, had levels of antibody to their homologous nematode antigens readily detectable by elisa. no cross-reactions were apparent when these serums were tested by elisa using oncosphere antigens of taenia hydatigena, t. pisifor ...19862421704
biochemical and immunologic characterization of a major surface antigen of dirofilaria immitis infective larvae.a 35 kd major surface antigen of dirofilaria immitis third-stage larvae was characterized biochemically and immunologically. living larvae were iodinated by using iodo-gen, iodosulfanilic acid, lactoperoxidase-glucose oxidase, and bolton-hunter reagents. detergent extracts of larvae labeled by the first three methods showed one major 35 kd component and a number of smaller components of about 6 kd, as analyzed by one-dimensional sds-page. in contrast, extracts from larvae labeled with the bolton ...19862419445
effects of milbemycin oxime on adult hookworms in dogs with naturally acquired infections.previous work indicated that adult ancylostoma caninum can be removed from experimentally infected dogs, using a formulation of milbemycin oxime at dosage of 0.5 mg/kg of body weight. to determine the efficacy of this treatment in dogs naturally infected with adult hookworms, 24 mixed-breed dogs with patent hookworm infections were purchased from an out-of-state vendor, and 6 male and 6 female dogs were assigned to either a control group or a group that would be treated. dogs were treated 10 day ...19902316928
field trials of the anthelmintic efficacy of nitroscanate and mebendazole in dogs.the efficacies of nitroscanate and mebendazole against nematodes and dipylidium caninum were compared by the examination of the faeces of 155 dogs. in unweaned puppies nitroscanate acted significantly faster and was significantly more effective than mebendazole against toxocara canis. in adult dogs, both drugs had a low efficacy against trichuris vulpis but a similarly good efficacy against other nematodes, with a tendency for nitroscanate to be more effective in reducing the prevalence of ancyl ...19902309388
metalloproteases of infective ancylostoma hookworm larvae and their possible functions in tissue invasion and ecdysis.to infect their hosts, hookworm larvae must exsheath and migrate through connective tissue. a modified in vitro skin chamber was used to show that the human hookworm ancylostoma duodenale and the zoonotic canine hookworm ancylostoma caninum penetrate epidermis, basement membrane, and dermis in similar ways. these similarities in tissue invasion properties reflect the observed biochemical similarities in parasite protease composition. the larvae of both species contain protease activity that is i ...19902254016
extrusion of the residual body in spermatids of ancylostoma caninum (nematoda, strongyloidea).transmission electron microscopy reveals that the spermatocytes of the hookworm ancylostoma caninum contain an abundance of golgi complexes, ribosomes, specialized membranous organelles, and long strands of smooth endoplasmic reticulum. these organelles remain abundant until the early spermatid stage of sperm development, when they reach their maximum abundance and maturity and the production of new ones ceases. golgi complexes, ribosomes, and excess ser, which are not functional after this stag ...19902160020
serum-stimulated feeding in vitro by third-stage infective larvae of the canine hookworm ancylostoma caninum.developmentally arrested nonfeeding infective larvae of hookworms resume development after entry into the host, presumably in response to a signal encountered during invasion. logically, an initial step in the resumption of development might be the resumption of feeding. an in vitro assay for feeding is described for the third-stage larvae of the canine hookworm ancylostoma caninum. populations of larvae incubated under hostlike conditions in the presence of 10% canine serum resume feeding withi ...19902112598
efficacy of nitroscanate against naturally acquired infection with ancylostoma caninum, dipylidium caninum, and trichuris vulpis in dogs.eighteen dogs with naturally acquired helminth infections were used to evaluate the efficacy of nitroscanate against ancylostoma caninum, dipylidium caninum, and trichuris vulpis. approximately 15 minutes before treatment, the dogs were given 100 to 200 g of canned dog food. ten dogs were treated with nitroscanate (50 mg/kg of body weight, po), and 8 dogs were given placebo tablets po. the dogs were euthanatized and necropsied 10 days after treatment and helminths were recovered from the small i ...19912053726
effects of milbemycin oxime on adult ancylostoma caninum and uncinaria stenocephala in dogs with experimentally induced infections. 19912021256
parasites, pets, and people.it is important for the family physician to understand that patients' relationships with their pets play an important role in helping maintain mental and physical health yet provide the potential for causing illness in the patient. toxocara canis (dog roundworm) and toxocara cati (cat roundworm) are the ascarids most commonly responsible for vlm and ocular larva migrans in humans. these roundworms live in their adult stage in the small intestine of the dog and cat where their eggs are passed in ...19912011635
zinc sulfide in intestinal cell granules of ancylostoma caninum adults.a source of confusion has existed since the turn of the century about the reddish brown, weakly birefringent "sphaerocrystals" located in the intestines of strongyle nematodes, strongylus and ancylostoma. x-ray diffraction and energy dispersive spectrometric analyses were used for accurate determination of the crystalline order and elemental composition of the granules in the canine hookworm ancylostoma caninum. the composition of the intestinal pigmented granules was identified unequivocally as ...19912010861
hookworm folliculitis.a case of persistent folliculitis in a 21-year-old man was demonstrated to be due to ancylostoma caninum larvae. treatment with oral thiabendazole was curative. cutaneous larva migrans may be due to a caninum, but this presentation appears to be unique. the literature concerning etiology and pathogenesis of larva migrans is discussed with reference to this case.19912006880
human eosinophilic enteritis caused by dog hookworm ancylostoma caninum.an epidemic of eosinophilic enteritis (93 cases) has occurred in townsville, northern queensland, australia. a hookworm was found attached to a resected, inflamed ileal segment from 1 patient but the species could not be identified. an adult hookworm of species ancylostoma caninum was recovered at colonoscopy from the terminal ileum of a later patient. all of 38 patients interviewed in an epidemiological survey described behaviour which could have exposed them to infective larvae of this widespr ...19901971376
transaminases changes and worm burden in multiple infection of ancylostoma caninum in mice.aspartate transaminase level was significantly increased in intestine of experimentals that received multiple doses of infection. the level of alanine transaminase rose to a significant value in liver of mice infected with multiple doses. rise of transaminases is correlated with the necrosis (disruption of intestina) hepatic cells in infected mice. changes and/or the distribution of aspartate transaminase and alanine transaminase with regard to the dosage is discussed.19911940329
host-finding and host recognition of infective ancylostoma caninum larvae.a. caninum larvae responded to environmental and host stimuli with four behavioral phases of host-finding. (1) snake-like movement was stimulated by warmth and by defined vibrations of the substratum. (2) waving behavior was a prerequisite for the passive change-over to dog hairs. it was stimulated by heat radiation and by the co2 content, warmth, and humidity of an air stream. (3) creeping direction: the larvae were attracted by heat in temperature gradients as weak as 0.04 degrees c mm-1 and b ...19911917283
effect of milbemycin oxime against ancylostoma caninum in dogs with naturally acquired infection.twenty-six mixed-breed (14 males, 12 females) dogs were used in a double-blind study to evaluate the effect of milbemycin oxime against naturally acquired infection with ancylostoma caninum. dogs were ranked and paired, on the basis of number of hookworm eggs/g of feces, and treatment was randomly assigned. each dog was given either the study drug or placebo (1 tablet/11.4 kg [0.5 mg/kg] of body weight). eggs per gram of feces enumeration was done on days 3 and 7 after treatment, and dogs were e ...19911883101
[parasitologic, clinical, hematologic and serologic findings in puppies after lactogenic infection with ancylostoma caninum ercolani 1859 (ancylostomidae)].the correlation between intensity of ancylostoma caninum infections in bitches and the intensity of lactogenic infections and clinical signs of their puppies was investigated. on average, 825, 1,867 or 2,125 specimens were observed in litters of two bitches inoculated with 5,000, 10,000 or 20,000 third stage larvae (liii) respectively, at the day of conception. adverse effects of the infection on the growth and behaviour of the puppies were observed after onset of their second week of life: 11/2 ...19911853668
effects of alcohol on natural resistance to ancylostoma caninum in mice.experiments were performed to study the effect of alcohol on natural immunity of swiss albino mice during ancylostoma caninum infection. natural resistance is lowered in alcoholic mice; 40% alcohol by mouth produced significant effect after 20 daily injections. the effect of the drug on natural immunity depended upon the concentration and the period of consumption. animals retained maximum number of larvae during alcohol treatment.19911804867
anthelmintic activity of paraherquamide in dogs.paraherquamide, an oxindole alkaloid metabolite of penicillium paraherquei and penicillium charlesii, was tested against the common gastrointestinal nematodes of dogs at a single oral dosage of 0.5, 1.0, or 2.0 mg kg-1. efficacy was poor (less than 85%) against ancylostoma caninum, uncinaria stenocephala, toxascaris leonina, trichuris vulpis, and strongyloides stercoralis at the low- and mid-dosage levels. at the high dosage level, good efficacy (91%) was observed only against s. stercoralis. ad ...19911788941
evaluation of a beef-based chewable formulation of pyrantel pamoate against induced and natural infections of hookworms and ascarids in dogs.pyrantel pamoate, formulated in a beef-based chewable tablet, was evaluated for efficacy in dogs against induced and natural infections of toxocara canis, toxascaris leonina, ancylostoma caninum and uncinaria stenocephala. dose titration trials were conducted in canada, the uk and germany in dogs treated with pyrantel (as pamoate salt) at 0, 2.5, 5 or 10 mg kg-1 body weight. these studies showed that a dose rate of 2.5 mg kg-1, the efficacy of pyrantel against adult t. canis, t. leonina, u. sten ...19911763481
identification of dirofilaria immitis-infected dogs with a coagglutination assay.the presence of dirofilaria immitis excretory-secretory (es) products was detected in the urine of infected dogs using a coagglutination assay. urine samples from 30 naturally infected dogs were positive. seventeen of them were microfilaremic, whereas 13 had become amicrofilaremic after receiving 2 courses of diethylcarbamazine. urine samples from 20 dogs infected with other parasites, dipetalonema reconditum (7), toxocara canis (5), and ancylostoma caninum (8), and urine samples from 20 healthy ...19921738064
albumin and a dialyzable serum factor stimulate feeding in vitro by third-stage larvae of the canine hookworm ancylostoma caninum.previous studies demonstrated that third-stage, developmentally arrested larvae of the canine hookworm ancylostoma caninum resume feeding in vitro in response to canine serum and hostlike temperature. experiments to determine the identity of the serum stimulus are described. serum from several nonhost species stimulated feeding, but to levels lower than canine serum. heating the serum to 57 c had no effect on its stimulatory ability. dialysis reduced serum stimulatory activity by 50%, and ultraf ...19911713962
ancylostoma caninum: reduced glutathione stimulates feeding by third-stage infective larvae.the resumption of feeding in vitro has been proposed as an indicator of the reactivation of development by arrested third-stage hookworm larvae. the tripeptide glutathione was tested for its ability to induce in vitro feeding by third-stage infective larvae of the canine hookworm ancylostoma caninum. reduced glutathione, but not oxidized glutathione, stimulated larval feeding in a specific, concentration-dependent manner. feeding began at 5-10 mm, and reached a plateau at 25-50 mm. incubation in ...19921639163
efficacy of ivermectin and pyrantel pamoate combined in a chewable formulation against heartworm, hookworm, and ascarid infections in dogs.eight trials were conducted in dogs to document the efficacy of ivermectin (6 micrograms/kg of body weight) and pyrantel pamoate (5 mg of active pyrantel/kg) in a beef-based chewable formulation against dirofilaria immitis, ancylostoma caninum, uncinaria stenocephala, toxocara canis, and toxascaris leonina. three studies involved induced infection with d immitis, and 5 studies involved induced or natural infection with hookworms and ascarids. in 3 intestinal parasite trials, the efficacy of the ...19921586021
comparison of febantel tablets and vercom paste against gastrointestinal nematodes of dogs.thirty adult dogs with naturally acquired gastrointestinal nematode infections were assigned at random to ten replicates and treated daily for 3 days with either a combination febantel/praziquantel (vercom) paste, febantel tablets or placebo tablets. numbers of hookworm and whipworm eggs after treatment were reduced similarly for both drug formulations when compared with pretreatment egg counts, whereas these counts increased in the controls. vercom paste reduced the hookworm egg count by 99.9% ...19921561756
efficacy of an ivermectin/pyrantel pamoate chewable formulation against the canine hookworms, uncinaria stenocephala and ancylostoma caninum.the effectiveness of the combination of pyrantel pamoate (5 mg kg-1) and ivermectin (6 micrograms kg-1) against the canine hookworms uncinaria stenocephala and ancylostoma caninum was determined. this combination is intended for monthly use as a heartworm preventative and for treatment and control of canine hookworms. the formulation was found to be effective (99.6% reduction in worm burdens) against both species of hookworms in experimentally infected dogs. no adverse effects due to the drug co ...19921532872
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