Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| sites of integration of infectious dna of avian reticuloendotheliosis viruses in different avian cellular dnas. | the pattern of integration for the infectious dna of two avian reticuloendotheliosis viruses whose dna is not inactivated by digestion with the restriction endonuclease, eco ri was determined. high molecular weight dna from infected chicken, turkey and pheasant cells was digested with eco ri, electrophoresed through agarose gels and assayed for infectivity. the same patterns of integration of infectious viral dna were found for these species of avian cells infected at high or low multiplicities ... | 1978 | 203406 |
| transformation of chick embryo fibroblasts by reticuloendotheliosis virus. | 1977 | 201089 | |
| nucleotide sequences derived from pheasant dna in the genome of recombinant avian leukosis viruses with subgroup f specificity. | recombination between viral and cellular genes can give rise to new strains of retroviruses. for example, rous-associated virus 61 (rav-61) is a recombinant between the bryan high-titer strain of rous sarcoma virus (rsv) and normal pheasant dna. nucleic acid hybridization techniques were used to study the genome of rav-61 and another rav with subgroup f specificity (rav-f) obtained by passage of rsv-rav-0 in cells from a ring-necked pheasant embryo. the nucleotide sequences acquired by these two ... | 1977 | 199737 |
| contact-mediated suppression of mitogen-induced responsiveness by spleen cells in reticuloendotheliosis virus-induced tumorigenesis. | 1977 | 199358 | |
| relationships between reticuloendothelial virus of chickens and an agent isolated from a duck embryo cell culture of turkey herpesvirus. | 1976 | 197293 | |
| serological survey of reticuloendotheliosis virus infection among chickens in japan. | 1977 | 196224 | |
| phenotypic mixing between reticuloendotheliosis virus and avian sarcoma viruses. | 1977 | 195392 | |
| formation of reticuloendotheliosis virus pseudotypes of rous sarcoma virus. | superinfection of chicken embryo fibroblasts transformed by the defective bryan strain of rous sarcoma virus (bh-rsv) with two different reticuloendotheliosis viruses (revs), rev strain t (rev-t) or spleen necrosis virus (snv), resulted in the production of infectious sarcoma virus pseudotypes. these pseudotypes were neutralized by antiserum prepared against snv and were unable to infect chicken cells preinfected with either rev-t or snv. these results suggest that defective bh-rsv is able to us ... | 1977 | 195082 |
| experimental transmission of reticuloendotheliosis in turkeys with the cell-culture-propagated reticuloendotheliosis viruses of turkey origin. | 1977 | 194046 | |
| pseudotypes of vesicular stomatitis virus with the mixed coat of reticuloendotheliosis virus and vesicular stomatitis virus. | vesicular stomatitis virus (vsv) forms pseudotypes with envelope components of reticuloendotheliosis virus (rev). the vsv pseudotype possesses the limited host range and antigenic properties of rev. approximately 70% of the vsv, indiana serotype, and 45% of vsv, new jersey serotype, produced from the rev strain t-transformed chicken bone marrow cells contain mixed envelope components of both vsv and rev. vsv pseudotypes with mixed envelope antigens can be neutralized with excess amounts of eithe ... | 1977 | 191647 |
| pathogenesis of abnormal feathers in chickens inoculated with reticuloendotheliosis virus. | abnormal feathers, characterized by thinness and increased transparency of the calamus and rachis, and loss of barbs, were induced at a high frequency by inoculating day-old chicks with reticuloendotheliosis virus (rev) propagated in chicken-embryo fibroblast (cef) cultures. the few birds that survived inoculation with oncogenic stock of rev derived from liver tissue of an infected chick developed similar abnormalities. lesions of an inflammatory-degenerative type were observed in close associat ... | 1977 | 190996 |
| infectious dna of spleen necrosis virus is integrated at a single site in the dna of chronically infected chicken fibroblasts. | the infectious dnas of a number of avian leukosis-sarcoma and reticuloendotheliosis viruses were digested with six nucleotide-specific restriction endonucleases, and the digests were tested for infectivity. all of the enzymes inactivated the viral infectivities except for ecori, which did not inactivate the infectivity of the dna of two of the reticuloendotheliosis viruses, spleen necrosis and chick syncytial viruses. the infectious dna of spleen necrosis virus after digestion with ecori had a b ... | 1977 | 189309 |
| isolation of a reticuloendotheliosis virus from chickens inoculated with marek's disease vaccine. | over a period from spring to fall in 1974, a disease with delayed growth, anemia, abnormal feathers, and leg paralysis as main symptoms broke out in flocks of chickens inoculated with marek's disease vaccine. a virus was isolated from affected birds in the field and the same lot of marek's disease vaccine as inoculated into these birds. it had a common antigenicity to the t strain of reticuloendotheliosis virus (rev) and could not be discriminated from this strain on the basis of morphology or p ... | 1976 | 189220 |
| inoculation experiment of marek's disease vaccine contaminated with a reticuloendotheliosis virus. | two-day-old chicks were inoculated with one or ten doses of marek's disease (md) vaccine originated from the herpesvirus of turkeys (hvt) and contaminated with a reticuloendotheliosis virus (rev). as a result, they presented such symptoms as abnormality in the vane of remiges, undergrowth, anemia, and leg paralysis. these symptoms were the same as those induced by the same vaccine among chicks in the field. control chicks which had been placed in the same house as those inoculated with the vacci ... | 1976 | 189219 |
| studies on the etiology of lymphomas in turkeys: isolation of reticuloendotheliosis in virus. | studies of tissues from 25 normal turkey flocks and of 15 selected turkey lymphoid tumors revealed no marek's disease or lymphoid leukosis viruses, although reticuloendotheliosis viruses (rev) were isolated from 3 flocks (2 with a history of neoplastic disease). the rev isolates were culturally and antigenically similar to the prototype rev strain t but were of low pathogenicity. attempts failed to transmit 6 lymphoid tumors of diverse origin by inoculation into 2 strains of recipient turkeys. t ... | 1976 | 186011 |
| a study of plaque formation with avian rna tumor viruses. | 1976 | 183351 | |
| rna polymerase activity in purified virions of avian reticuloendotheliosis viruses. | an rna polymerase activity that synthesizes a u-rich rna hydrogen bonded to a large viral rna molecule was found in the cores of virions of avian reticuloendotheliosis viruses (rev). the rna polymerase activity was separable from the dna polymerase activity of rev virions. the 5'-terminus of the newly synthesized rna was a. in addition, a trna nucleotidyl transferase activity, which added -cpcpa ends to trna, appears to be present in the rev virions. | 1976 | 183017 |
| reticuloendotheliosis group virus pathogenic to chicken isolated from material infected with turkey herpesvirus (hvt). | 1976 | 180962 | |
| a lymphoproliferative disease in japanese quail. | a naturally occurring lymphoproliferative disease was found in 3 flocks of japanese quail in mexico. the tumorlike lesions were detected mainly in livers and spleens. histopathology revealed a pleomorphic lymphoproliferative infiltration with dark-staining large cells, lymphocytes of different sizes, and reticulumlike cells. marek's disease (md) herpesvirus was not isolated from 74 quail tested, nor were antibodies to md detected in 84 sera. antibodies to reticuloendotheliosis (3/24) and avain l ... | 1976 | 176987 |
| genomic complexities of murine leukemia and sarcoma, reticuloendotheliosis, and visna viruses. | the genetic complexities of several ribodeoxyviruses were measured by quantitative analysis of unique rnase t1-resistant oligonucleotides from 60-70s viral rnas. moloney murine leukemia virus was found to have an rna complexity of 3.5 x 10(6) daltons, whereas moloney murine sarcoma virus had a significantly smaller genome size of 2.3 x 10(6). reticuleondotheliosis and visna virus rnas had complexities of 3.9 x 10(6), respectively. analysis of rnase a-resistant oligonucleotides of rous sarcoma vi ... | 1976 | 176429 |
| effect of medium of lowered nacl concentration on virus release and protein synthesis in cells infected with reticuloendotheliosis virus. | when cultures producing reticuloendotheliosis virus were incubated for 24 h in medium of lowered nacl concentration, virus production was inhibited. the extent of inhibition increased as the salt concentration of the medium was decreased. the inhibition was rapidly reversed by replacement of low-salt medium with normal medium. during the first hour after the inhibited cultures were returned to normal medium, virus was released at an accelerated rate, making the total amount of virus released by ... | 1976 | 176425 |
| naturally occurring reticuloendotheliosis in turkeys: transmission. | this report describes the natural occurrence and experimental transmission of reticuloendotheliosis in a turkey flock. in the naturally affected turkeys, lesions were present in the liver, spleen, heart, intestines, and peripheral nerves, and were composed mainly of lymphoreticular cells. the disease was experimentally reproduced in turkey poults with cellfree tissue extracts of infected birds. a type-c rna virus similar to reticuloendotheliosis virus (strain t) was present in the tissues of tur ... | 1976 | 176388 |
| enhancement and interference in chickens inoculated with marek's disease herpesvirus and oncornaviruses. | enhancement of mortality rates and symptomatology was observed in isolator-held lsi-spf chickens concurrently inoculated with mdhv and avian oncornaviruses (rav-1, rav-2, rav-7, rav-50, or rev). interference with md antigen production also was demonstrated in extracts of the feather follicle epithelium from chickens inoculated with both mdhv and rav-1. | 1975 | 174137 |
| polypeptide and rna composition of the reticuloendotheliosis viruses. | the rna and polypeptide composition of chick syncytial virus (csv) and duck infectious anemia virus (diav) was investigated and compared to that of reticuloendotheliosis virus (rev) strain t, the prototype of the newly recognized rev group of viruses. csv and diav contain genomic rna species which cosediment with those of rev in sucrose gradients. five or six polypeptides, two of which are glycoproteins, were consistently found in csv and diav preparations. the major nonglycosylated polypeptides ... | 1975 | 172472 |
| comparative ultrastructural study of four reticuloendothelias viruses. | the morphology and development of four members of the reticuloendotheliosis virus group were studied by transmission electron microscopy. virions of duck spleen necrosis virus, duck infectious anemia virus, chicken syncytial virus, and reticuloendotheliosis virus strain t are sperical with a diameter of approximately 110 nm. they are covered with surface projections about 6 nm long and 10 nm in diameter. the center-to-center distance of surface projections is about 14 nm. the budding virions con ... | 1975 | 170410 |
| infectious dna from cells infected with rous sarcoma virus, reticuloendotheliosis virus or rous-associated virus-o. | we have described an efficient and quantitative assay for infectious dna of the avian ribodeoxyviruses and have applied this method to study the possible existence of infectious viral dnas in uninfected cells. infectious dna from cells infected with rsv or rev consisted of a single unit of dna with a specific infectivity of 10(-5)-10(-6). the minimum molecular weight of rsv dna required for infection of chicken cells was about 6 million, while the minimum molecular weight of infectious rev dna w ... | 1975 | 169004 |
| replication of reticuloendotheliosis viruses in cell culture: chronic infection. | after an initial acute infection with cell killing, chicken or duck embryo fibroblasts infected in culture with reticuloendotheliosis viruses set up a chronic infection with no cell killing or morphological transformation. essentially all of the chronically infected cells produced virus. the virus production was not sensitive to cytosine arabinoside or mitomycin c as was virus production in an acute infection. the chronically infected cells had a strong group-specific resistancto the c.p.e. of s ... | 1975 | 167114 |
| in vitro studies on allotype suppression. iii. compounds of antiallyotype serum active in release from allotype suppression. | spleen cells of b4b6 rabbits, shown to be deficient in their ability to produce b4ig due to prenatal exposure to anti-b4, formed anti-t2 antibodies marked with the b4 determinant in response to solubilized t2 phage (s-t2) only when cultured in the presence of antibodies specific for the nonsuppressed type (b6), thus confirming and extending the previously reported observation of release from b4 suppression in cultured cells of b4-suppressed b4b5 rabbits treated with anti-b5 serum. only antiallo ... | 1975 | 167094 |
| isolation and characterization of viruses from natural outbreaks of reticuloendotheliosis in turkeys. | we have described the in vitro isolation of type-c rna viruses from two outbreaks of a fatal neoplastic disease in turkeys we diagnosed as reticuloendotheliosis. the virus had a density of 1.16 g/ml in sucrose gradients, had a dna polymerase capable of using both endogenous and exogenous (synthetic) templates, and was infectious in vitro for turkey and chick cells. the culture-propagated virus was oncogenic for turkeys. the virus isolates were unrelated to avian leukosis virus and antigenically ... | 1975 | 166189 |
| studies on the replication of reticuloendotheliosis virus: detection of viral-specific dna sequences in infected chick cells. | 1975 | 165622 | |
| pheasant virus dna polymerase is related to avian leukosis virus dna polymerase at the active site. | the dna polymerase from amherst pheasant virus (apv), a member of the pheasant virus species of retroviruses, was compared to the dna polymerases of avian leukosis viruses (alv) and a reticuloendotheliosis virus (spleen necrosis virus (snv)). immunoglobulin inhibition tests and competition immunoassays showed that apv and alv dna polymerases are closely related at their active sites. the determinants common to their active sites are not shared by snv dna polymerase. bu using a species-specific r ... | 1979 | 94361 |
| biochemical characterization of the type c retrovirus associated with lymphoproliferative disease of turkeys. | turkeys inoculated with spleen extracts from lymphoproliferative disease (lpd)-affected birds developed viremia, followed by typical lpd lesions. electron microscopy and biochemical characterization established that the virus present in the blood of infected turkeys is a type c retrovirus. the viral particles possess a buoyant density of 1.17 g/ml in sucrose gradients; they contain high-molecular-weight rna and an rna-instructed dna polymerase with efficient exogenous and endogenous activity. th ... | 1979 | 90160 |
| avian reticuloendotheliosis viruses: evolutionary linkage with mammalian type c retroviruses. | reticuloendotheliosis viruses have been shown to be causative of tumors in a variety of avian species. the major structural protein of these non-genetically transmitted viruses is demonstrated to possess antigenic determinants common to those of all known mammalian type c viruses. these findings establish a mammalian origin for this oncogenic avian retrovirus group. none of the known mammalian type c virus groups demonstrated a closer immunological relationship to avian reticuloendotheliosis vir ... | 1979 | 89204 |
| comparison of the small rnas of polymerase-deficient and polymerase-positive rous sarcoma virus and another species of avian retrovirus. | the small rnas contained in virions of avian leukosis and sarcoma viruses are a virus-specific subset of the total small rna population of the host cell. the reverse transcriptase protein must be present in the budding virion for this selection to take place. virions of the alpha form of the bryan strain of rous sarcoma virus, which lack detectable reverse transcriptase, incorporated an unselected population of small rnas identical to total chicken cell small rna. virions of reticuloendotheliosi ... | 1979 | 87521 |
| reticuloendotheliosis virus: detection of immunological relationship to mammalian type c retroviruses. | reticuloendotheliosis virus (rev) p30 shares cross-reactive determinants and a common nh2-terminal tripeptide with mammalian type c viral p30's. an interspecies competition radioimmunoassay was developed, using iodinated rev p30 and a broadly reactive antiserum to mammalian virus p30's. the avian leukosis-sarcoma viruses and mammalian non-type c retroviruses did not compete in this assay. previous data indicating that the rev group is not represented completely in normal avian cell dna lead us t ... | 1979 | 87519 |
| rna-directed dna polymerase from particles released by normal goose cells. | cells from a goose embryo were shown to release particle-associated rna-directed dna polymerase and rnase h activities that required the presence of nonidet p-40 for detection. the particles were not infectious and did not have endogenous dna synthesis. the goose particle dna polymerase was related to the dna polymerase of spleen necrosis virus with respect to size and was inhibited by immunoglobulin g to spleen necrosis virus dna polymerase. however, goose cells producing dna polymerase-contain ... | 1979 | 87517 |
| isolation and characterization of a virus-specific ribonucleoprotein complex from reticuloendotheliosis virus-transformed chicken bone marrow cells. | chicken bone marrow cells transformed by reticuloendotheliosis virus (rev) produce in the cytoplasm a ribonucleoprotein (rnp) complex which has a sedimentation value of approximately 80 to 100s and a density of 1.23 g/cm3. this rnp complex is not derived from the mature virion. an endogenous rna-directed dna polymerase activity is associated with the rnp complex. the enzyme activity was completely neutralized by anti-rev dna polymerase antibody but not by anti-avian myeloblastosis virus dna poly ... | 1978 | 81319 |
| immunological characterization of the rna-dependent dna polymerase from reticuloendotheliosis virus. | 1977 | 74790 | |
| a very sensitive biochemical assay for detecting and quantitating avian oncornaviruses. | 1977 | 69360 | |
| characterization of a new reverse transcriptase of possibly cellular origin in the chicken system. | the properties of an rna-dependent dna polymerase, which occurs ubiquitously in the allantoic fluid of uninfected, leukosis-virus-free eggs, are described. it is shown that the enzyme can synthesize faithful transcripts from natural rna (globin mrna). with biochemical and immunological methods, the enzyme can be clearly distinguished from the reverse transcriptases of the known chicken rna tumour viruses and therefore seems to be a member of a so far unknown class of chicken polymerases. our dat ... | 1977 | 66920 |
| the reverse transcriptase. | 1977 | 66065 | |
| a new, not virus related reverse transcriptase in the chicken system. | 1976 | 64385 | |
| serotherapy of avian reticuloendotheliosis virus-induced tumors. | immune serum, obtained from animals that had survived sublethal challenge with re virus, was very effective in achieving tumor cures in chickens infected with this virus. the therapeutic effect could also be obtained by the immunoglobulin fraction of immune serum. the serum did not influence the development of an unrelated malignancy. serotherapy studies in bx and tx recipients indicate that the b-cell or t-cell system of the host does not significantly contribute to the curative activity of imm ... | 1976 | 63259 |
| an rna-dependent dna polymerase, different from the known viral reverse transcriptases, in the chicken system. | the properties of an rna-dependent dna polymerase (an rna-dependent dna nucleotidyltransferase), which occurs ubiquitously in the allantoic fluid of uninfected, leukosis-virus-free eggs, are described. it is shown that the enzyme can synthesize faithful transcripts from natural rna (globin mrna). by biochemical and immunological methods, the enzyme can be clearly distinguished from the reverse transcriptases of the known chicken rna tumor viruses and therefore seems to be a member of a so far un ... | 1976 | 61587 |
| pheasant virus: new class of ribodeoxyvirus. | cocultivation of cells derived from embryos of golden pheasants or amherst pheasants with chicken embryo cells infected with bryan strain of rous sarcoma virus resulted in the detection of viruses which appear to be endogenous in these pheasant cells. the pheasant viruses (pv) were similar to avian leukosis-sarcoma viruses (alsv) in their gross morphology, in the size of their rna, in the presence of a virion-associated rna-dependent dna polymerase (dna nucleotidyltransferase; deoxynucleoside tr ... | 1976 | 57621 |
| group-specific antigen shared by the members of the reticuloendotheliosis virus complex. | the polypeptides of reticuloendotheliosis virus (rev) were separated by gel filtration in the presence of guanidine hydrochloride. the eight peaks obtained by gel filtration were then analyzed by polyacrylamide gel electrophoresis and four appeared to contain single polypeptides. the material identified as p29 was used to prepare antiserum. this protein constitutes the major internal non-glycosylated polypeptide in the virion. double immunodiffusion indicated that the antiserum was specific for ... | 1976 | 56462 |
| the reticuloendotheliosis viruses. | 1975 | 53119 | |
| characterization of endogenous rna-directed dna polymerase activity of reticuloendotheliosis viruses. | reticuloendotheliosis viruses (rev) contain an endogenous rna-directed dna polymerase activity. the endogenous dna polymerase activity can be elicited in purified preparations of rev by treatment with nonionic detergents. the enzyme activity has a strong preference for manganous ions. therefore, appreciable endogenous dna polymerase activity can be demonstrated only if the reaction mixture contains appropriate concentrations of manganous ions. enzyme activity can be inhibited by pretreatment wit ... | 1975 | 51936 |
| rna-directed dna polymerase activity of reticuloendotheliosis virus: characterization of the endogenous and exogenous reactions. | reticuloendotheliosis virus (rev) contains an endogenously instructed, rna-directed dna polymerase activity. both the endogenous and exogenous dna polymerase activities exhibited up to 10-fold greater activity at the optimum concentration of manganous ion (0.025 mm for exogenous; 0.25 mm for endogenous) than at any concentration of magnesium ion. antiserum to the dna polymerase of an rev group virus (spleen necrosis virus) inhibited both endogenous and exogenous dna polymerase activity of rev, w ... | 1975 | 51935 |
| a comparative study of the avian reticuloendotheliosis virus: relationship to murine leukemia virus and viruses of the avian sarcoma-leukosis complex. | 1975 | 48309 | |
| dna polymerase of reticuloendotheliosis virus: inability to detect endogenous rna-directed dna synthesis. | 1975 | 48308 | |
| characteristics of two new reticuloendotheliosis virus isolates of turkeys. | reticuloendotheliosis (re) virus strains mn81 and mn67 isolated from epiornithics of re in turkeys were partially characterized. strains mn81 and mn67 replicated in chicken embryo fibroblast,duck embryo fibroblast and turkey embryo-fibroblast cultures and produced syncytial cytopathic effects in duck embryo fibroblast and turkey embryo fibroblast cultures. the virions of mn81 and mn67 measured approximately 100 nm in diameter, resembled re virus strain t, and could be distinguished from avian le ... | 1977 | 15487 |