Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| do cdk4/6 inhibitors have potential as targeted therapeutics for squamous cell cancers? | introduction dysregulation of cell cycle progression has an established link to neoplasia and cancer progression. components of the cyclin d-cdk4/6-ink4-rb pathway are frequently altered in squamous cell carcinomas (sccs) by diverse mechanisms, including viral oncogene-induced degradation, mutation, deletion, and amplification. activation of the cdk4/6 pathway may predict response to cdk4/6 inhibitors and provide clinical biomarkers. recently, the cdk4/6 inhibitor palbociclib showed clinical eff ... | 2017 | 28042706 |
| human papillomavirus at multiple sites associated with anal squamous intraepithelial lesions in hiv-seropositive individuals. | hiv-seropositive patients have higher risk of hpv infection even on anti-retroviral therapy. infection with high-risk hpv genotypes can cause dysplasia leading to cancer. this study assessed hpv at different anatomical sites in hiv-seropositive individuals and factors associated with anal squamous intraepithelial lesions (asil). | 2016 | 28042618 |
| immunogenicity and safety of human papillomavirus (hpv) vaccination in asian populations from six countries: a meta-analysis. | cervical cancer is a serious public-health problem in asian countries. since human papillomavirus (hpv) infection is the main risk factor for cervical cancer, hpv vaccination is considered a promising strategy to prevent cervical cancer. however, comprehensive immunogenicity and safety information for asian populations is lacking. we searched four electronic databases including pubmed, embase, cochrane library, and clinicaltrials.gov. we reviewed selected manuscripts and extracted the pooled rel ... | 2017 | 28042137 |
| development and validation of a preanalytic procedure for performing the cobas hpv test in surepath preservative fluid. | the formation of chemical cross-links between nucleic acids and proteins in formalin-containing media presents challenges for human papillomavirus (hpv) testing of cervical samples collected in surepath preservative fluid. a preanalytic process involving addition of a nucleophilic buffer and heating the sample to 120°c was developed to reverse the effects of cross-linking and improve nucleic acid accessibility for the cobas hpv test in surepath. cycle threshold (ct) values for cobas hpv detectio ... | 2017 | 28041871 |
| vulvar cancer, version 1.2017, nccn clinical practice guidelines in oncology. | vulvar cancer is a rare gynecologic malignancy. ninety percent of vulvar cancers are predominantly squamous cell carcinomas (sccs), which can arise through human papilloma virus (hpv)-dependent and hpv-independent pathways. the nccn vulvar cancer panel is an interdisciplinary group of representatives from nccn member institutions consisting of specialists in gynecological oncology, medical oncology, radiation oncology, and pathology. the nccn clinical practice guidelines in oncology (nccn guidel ... | 2017 | 28040721 |
| the low-risk papillomaviruses. | human papillomavirus (hpv) research has been dominated by the study of a subset of alpha papillomaviruses that together cause almost 5% of human cancers worldwide, with the focus being on the two most prominent of these (hpv16 and 18). these viruses are referred to as 'high-risk' (hrhpv), to distinguish them from the over 200 prevalent hpv types that more commonly cause only benign epithelial lesions. the 'low-risk' (lrhpv) term used to describe this group belies their cumulative morbidity. pers ... | 2017 | 28040475 |
| human papillomavirus status and the relative biological effectiveness of proton radiotherapy in head and neck cancer cells. | human papillomavirus (hpv)-positive oropharyngeal carcinomas response better to x-ray therapy (xrt) than hpv-negative disease. whether hpv status influences the sensitivity of head and neck cancer cells to proton therapy or the relative biological effectiveness (rbe) of protons versus xrt is unknown. | 2017 | 28039958 |
| human papillomavirus (hpv) persistence and hpv 31 predict the risk of recurrence in high-grade vaginal intraepithelial neoplasia. | high-grade vaginal intraepithelial neoplasia (vaginal hsil) represents an uncommon entity. here, we sought to identify predictors for recurrence and risk factor for developing genital cancers after primary treatment for vaginal hsil. | 2016 | 28039759 |
| corrigendum to "an association of dnmt3b protein expression with p16ink4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection" [cancer lett. 226 (1) (2005 aug 8) 77-84]. | 2017 | 28038969 | |
| [immunisation schedule of the spanish association of paediatrics: 2017 recommendations]. | the advisory committee on vaccines of the spanish association of paediatrics (cav- aep) annually publishes the immunisation schedule which, in our opinion, is considered optimal for children resident in spain, taking into account the evidence available on current vaccines. pneumococcal and varicella immunisation in early childhood is already included in all funded vaccines present in the regional immunisation programmes. furthermore, this committee establishes recommendations on vaccines not inc ... | 2017 | 28038948 |
| pharmacy student involvement with increasing human papillomavirus (hpv) vaccination among international college students. | 2017 | 28038698 | |
| different association of human papillomavirus 16 variants with early and late presentation of cervical cancer. | the median age of cervical cancer (cc) presentation coincides with the mean age of menopause presentation (49 years) in mexico. here, we investigated the association between different hpv16 variants and early (≤ 49 years) or delayed (≥ 50 years) cc presentation. we conducted a case-case study that included 462 ccs, 386 squamous cell carcinomas (scc), 63 adenocarcinomas (acc), and 13 additional cell types. variants were identified by pcr and dna sequencing. the risk conferred by each variant for ... | 2016 | 28036379 |
| itpr3 gene haplotype is associated with cervical squamous cell carcinoma risk in taiwanese women. | host immunogenetic background plays an important role in human papillomavirus (hpv) infection and cervical cancer development. inositol 1,4,5-triphosphate receptor type 3 (itpr3) is essential for both immune activation and cancer pathogenesis. we aim to investigate if itpr3 genetic polymorphisms are associated with the risk of cervical cancer in taiwanese women. itpr3 rs3748079 a/g and rs2229634 c/t polymorphisms were genotyped in a hospital-based study of 462 women with cervical squamous cell c ... | 2017 | 28036301 |
| human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases. | human papillomavirus (hpv) is known as causative for squamous cell carcinoma (scc) of the oropharynx, but is also found not infrequently in carcinomas of the sinonasal tract. recently, a subset of these carcinomas was recognized to harbour hpv33 and have a significant morphological overlap with adenoid cystic carcinoma (acc), a rare and aggressive carcinoma originating in the minor salivary glands. termed 'hpv-related carcinoma with acc-like features', only nine cases have been reported. to clar ... | 2016 | 28035703 |
| increased expression of pd-l1 by the human papillomavirus 16 e7 oncoprotein inhibits anticancer immunity. | cytotoxic t lymphocyte dysfunction is frequently associated with pd‑l1/pd‑1 pathway activation, and is a principal obstacle in cancer therapy. in the present study, the mechanisms underlying the human papillomavirus (hpv)‑induced evasion of cervical cancer cells to the host immune system via the programmed death ligand 1/programmed death 1 (pd‑l1/pd‑1) signaling pathway was investigated. a significant increase in the expression of the hpv16e7 viral protein and pd‑l1 in cervical tissues was obse ... | 2016 | 28035385 |
| incidental finding of an extensive oropharyngeal mass in magnetic resonance imaging of a patient with temporomandibular disorder: a case report. | in this report, we describe the incidental finding of an oropharyngeal mass in a patient who presented with a chief complaint of temporomandibular pain. the patient was initially evaluated by an otorhinolaryngologist for complaints of headaches, earache, and sinus congestion. due to worsening headaches and trismus, he was further referred for the management of temporomandibular disorder. the clinical evaluation was uneventful except for limited mouth opening (trismus). an advanced radiological e ... | 2016 | 28035308 |
| bilateral plantar verrucous carcinoma. | 2016 | 28035248 | |
| activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of onconase. | onconase is a ribonuclease that presents both antitumor and antiviral properties linked to its ribonucleolytic activity and represents a new class of rna-damaging drugs. it has reached clinical trials for the treatment of several cancers and human papilloma virus warts. onconase targets different rnas in the cell cytosol but onconase-treated cells present features that are different from a simple arrest of protein synthesis. we have used microarray-derived transcriptional profiling to identify o ... | 2016 | 28035074 |
| sustained antibody responses 6 years following 1, 2, or 3 doses of quadrivalent human papillomavirus (hpv) vaccine in adolescent fijian girls, and subsequent responses to a single dose of bivalent hpv vaccine: a prospective cohort study. | the duration of antibody response following reduced human papillomavirus (hpv) vaccine doses has not been determined. we compared the antibody responses in girls previously vaccinated with zero, 1, 2, or 3 doses of quadrivalent hpv vaccine (4vhpv; gardasil, merck) 6 years previously. | 2017 | 28034886 |
| vaccines against human papillomavirus infections: protection against cancer, genital warts or both? | since 2006, three vaccines against infections and disease caused by human papillomavirus (hpv) became available in europe-in 2006 a quadrivalent hpv 6/11/16/18 vaccine, in 2007 a bivalent hpv 16/18 vaccine and in 2015 a nonavalent hpv 6/11/16/18/31/33/45/52/58 vaccine. hpv 16 and 18 are the most oncogenic hpv strains, causing about 70% of cervical and other hpv-related cancers, hpv 6 and 11 cause 85% of all genital warts. the additional types of the polyvalent vaccine account for about 20% of in ... | 2016 | 28034371 |
| production of polyclonal antibody to the hpv58 e7 protein and its detection in cervical cancer. | the persistent infection of high-risk human papillomavirus (hpv) is one of the most common causes of cervical cancer worldwide, and hpv type 58 is the third most common hpv type in eastern asia. the e7 oncoprotein is constitutively expressed in hpv58-associated cervical cancer cells and plays a key role during tumorigenesis. to study the biological function of hpv58 e7 and to characterize e7 protein-host cell interactions, we cloned the human hpv58 e7 gene and produced specific e7 antibodies. th ... | 2016 | 28033368 |
| recent trends in oral cavity cancer research support in the united states. | the objectives were to characterize oral cavity cancer (occ) funding from the national institutes of health (nih) with a secondary aim of comparing nih support provided to occ and other malignancies. nih awards supporting occ inquiry from 2000 to 2014 were accessed from the nih reporter database. these data were used to evaluate temporal trends and the role of human papilloma virus and to determine the academic training and professional profiles of the principal investigators. comparison of 2014 ... | 2017 | 28033064 |
| elevated expression of ox2r in cervical cancers and placentas of uyghur women in xinjiang, china | objective:cervical cancer is one of the major causes of mortality of uyghur women in xinjiang, china. although increased expression of orexin receptor (oxr), known to be strongly expressed in human placenta, has a proven relation to some cancers , there have been few studies of cervical cancer. thus, we explored this question by evaluating the expression of orexin receptor as a biomarker for screening early stage of cervical cancer in uyghur women with highest occurrence rate of cervical cancer ... | 2016 | 28032723 |
| tils in head and neck cancer: ready for clinical implementation and why (not)? | the assessment of tumor infiltrating lymphocytes (tils) has recently emerged as a prognostic biomarker in several solid tumors. quantification and subtyping of tils reflects the immune response in the tumor microenvironment, contributing to either tumoral immune attack or escape and thereby affecting outcome. despite the growing evidence of its value as prognosticator, tils analysis has not yet found its way to daily clinical practice. the aim of this review is to evaluate whether the current kn ... | 2016 | 28032290 |
| detection of human papilloma virus in potentially malignant and malignant lesions of the oral cavity and a study of associated risk factors. | squamous cell carcinoma of the head and neck is the 6(th) most frequently occurring cancer worldwide, with over 400,000 cases projected annually. multiple factors such as tobacco, alcohol, irradiation, virus, and chronic irritants are involved in the development of oral squamous cell carcinomas (osccs). the most important risk factors are chronic exposure to tobacco and alcohol. although the evidence that implicates virus is increasing, particularly (human papillomavirus [hpv]), in the carcinoge ... | 2017 | 28032082 |
| association of human papillomavirus 16 e2 with rad50-interacting protein 1 enhances viral dna replication. | rad50-interacting protein 1 (rint1) associates with the dna damage response protein rad50 during the transition from the s phase to the g2/m phase and functions in radiation-induced g2 checkpoint control. it has also been demonstrated that rint1 is essential in vesicle trafficking from the golgi apparatus to the endoplasmic reticulum (er) through an interaction with zeste-white 10 (zw10). we have isolated a novel interaction between rint1 and the human papillomavirus 16 (hpv16) transcription and ... | 2017 | 28031358 |
| human papilloma virus detection by innolipa hpv in prostate tissue from men of northeast mexico | background: prostatic adenocarcinoma by prosate cancer (pca) is the most prevalent cancer and the second cause of cancer-related death among men in the western world. human papilloma virus (hpv) may be considered as a preventable risk factor. in this study, we assessed the frequencies of hpv infection in prostatic adenocarcinoma and benign prostatic hyperplasia (bph) cases in northeast mexico. materials and methods: a total of 87 paraffin-embedded blocks (from 25 and 62 patients with definite di ... | 2016 | 28030912 |
| 1.5 ce test hours: human papillomavirus-related oral cancers: the nurse's role in mitigating stigma and dispelling myths. | 2017 | 28030406 | |
| ce: human papillomavirus-related oral cancers: the nurse's role in mitigating stigma and dispelling myths. | : the prevalence of human papillomavirus (hpv)-related oral cancers has been rising, the cancers occurring in adults at a younger age than hpv-negative oral cancers typically do and in men more often than women. patients who are diagnosed often don't understand the disease's etiology. because hpv is sexually transmitted, diagnosis with an hpv-related oral cancer may prompt feelings of shame, embarrassment, and guilt. there are currently three vaccines for hpv. it's essential for nurses to educat ... | 2017 | 28030405 |
| is induction chemotherapy needed to select patients for deintensified treatment of human papillomavirus-associated oropharyngeal cancer? | 2016 | 28029316 | |
| e1308: phase ii trial of induction chemotherapy followed by reduced-dose radiation and weekly cetuximab in patients with hpv-associated resectable squamous cell carcinoma of the oropharynx- ecog-acrin cancer research group. | purpose human papillomavirus (hpv)-associated oropharyngeal squamous cell carcinoma (opscc) is treatment-responsive. definitive chemoradiation results in high cure rates but causes long-term toxicity and may represent overtreatment of some patients. this phase ii trial evaluated whether complete clinical response (ccr) to induction chemotherapy (ic) could select patients with hpv-associated opscc for reduced radiation dose as a means of sparing late sequelae. methods patients with hpv16 and/or p ... | 2016 | 28029303 |
| human papillomavirus (hpv) in egyptian females: study by cytology, histopathology, colposcopy and molecular diagnosis of high risk types. | in northern africa, the region egypt belongs to, about 10.7% of women are estimated to harbour cervical human papillomavirus (hpv) infection and 78.4% of invasive cancers are attributed to hpvs 16 or 18. we aimed at comparing hpv detection by ish-pcr tissue with other conventional available cheaper techniques, finding which of them can be relied upon in a developing country like egypt for hpv detection. | 2016 | 28028296 |
| carcinogenesis of vulvar lesions: morphology and immunohistochemistry evaluation. | the aim of the study was to assess the 2 pathways of vulvar carcinogenesis and correlate immunohistochemical expression of p53 with histopathological findings. | 2017 | 28027121 |
| case of lupus erythematosus panniculitis triggered by human papillomavirus quadrivalent vaccine injection. | 2016 | 28026034 | |
| expression, polyubiquitination, and therapeutic potential of recombinant e6e7 from hpv16 antigens fused to ubiquitin. | ubiquitin-proteasome system plays an essential role in the immune response due to its involvement in the antigen generation and presentation to cd8(+) t cells. hereby, ubiquitin fused to antigens has been explored as an immunotherapeutic strategy that requires the activation of cytotoxic t lymphocytes. here we propose to apply this ubiquitin fusion approach to a recombinant vaccine against human papillomavirus 16-infected cells. e6e7 multi-epitope antigen was fused genetically at its n- or c-ter ... | 2017 | 28025776 |
| virus and host events in squamous carcinogenesis. | our group investigates early and late stages in the development of squamous cell carcinomas (sccs), in order to identify new approaches to diagnosis and therapy. the principal themes are:1. transcriptional deregulation of high-risk human papillomavirus (hrhpv)we study mechanisms of hrhpv transcriptional deregulation and competitive cell selection during scc progression, focussing on the causes and effects of integration of hpv16 into the host genome. we showed that hpv16 integration does not nec ... | 2016 | 28025425 |
| transmission between archaic and modern human ancestors during the evolution of the oncogenic human papillomavirus 16. | every human suffers through life a number of papillomaviruses (pvs) infections, most of them asymptomatic. a notable exception are persistent infections by human papillomavirus 16 (hpv16), the most oncogenic infectious agent for humans and responsible for most infection-driven anogenital cancers. oncogenic potential is not homogeneous among hpv16 lineages, and genetic variation within hpv16 exhibits some geographic structure. however, an in-depth analysis of the hpv16 evolutionary history was st ... | 2017 | 28025273 |
| the role of hpv on the risk of second primary neoplasia in patients with oropharyngeal carcinoma. | it has been reported that patients with hpv-positive oropharyngeal cancer (opc) have a lower risk of appearance of second primary neoplasm (spn) than hpv-negative opc patients. the aim of our study was to analyze the risk of developing spn in a large group of patients with opc according to hpv status in the primary tumor. | 2017 | 28024722 |
| coming of age? women's sexual and reproductive health after twenty-one years of democracy in south africa. | this paper is a sequel to a 2004 article that reviewed south africa's introduction of new sexual and reproductive health (srh) and rights laws, policies and programmes, a decade into democracy. similarly to the previous article, this paper focuses on key areas of women's srh: contraception and fertility, abortion, maternal health, hiv, cervical and breast cancer and sexual violence. in the last decade, south africa has retained and expanded its sexual and reproductive health and rights (srhr) po ... | 2016 | 28024682 |
| immune responses after 2 versus 3 doses of hpv vaccination up to 4½ years after vaccination: an observational study among dutch routinely vaccinated girls. | in 2014 the netherlands switched from 3 to 2 doses for routine vaccination with the prophylactic bivalent human papillomavirus (hpv) vaccine. the current study explored whether antibody responses are noninferior after 2 versus 3 doses in girls. | 2017 | 28011916 |
| trends and determinants of human papillomavirus concordance among hiv-positive and hiv-negative heterosexual couples in rakai, uganda. | limited data are available on human papillomavirus (hpv) infection among hiv-negative or hiv-positive couples followed longitudinally. | 2016 | 28011913 |
| effectiveness of hpv vaccination on prevalence of vaccine genotypes in young sexually active women in france. | effectiveness of human papillomavirus (hpv) vaccines in the context of both guidelines which recommend vaccination at 14 years and modest vaccine coverage is poorly documented. | 2016 | 28011911 |
| psychological impact of primary screening (pips) for hpv: a protocol for a cross-sectional evaluation within the nhs cervical screening programme. | the nhs cervical screening programme is now using human papillomavirus (hpv) testing as the primary test in six sentinel sites in england, with the intention of rolling this out across the whole of england. previous research evaluating hpv testing in the cervical screening context suggests that an hpv-positive result may increase anxiety beyond that associated with abnormal cytology, but this has not been explored in the context of primary hpv testing. the main aim of this study is to explore th ... | 2016 | 28011816 |
| impact and cost-effectiveness of selective human papillomavirus vaccination of men who have sex with men. | men who have sex with men (msm) have a high lifetime risk of anogenital warts and cancers related to infection with human papillomavirus (hpv). they also benefit less from herd protection than heterosexual males in settings with female-only hpv vaccination. | 2017 | 28011615 |
| electrochemical paper-based peptide nucleic acid biosensor for detecting human papillomavirus. | a novel paper-based electrochemical biosensor was developed using an anthraquinone-labeled pyrrolidinyl peptide nucleic acid (acpcpna) probe (aq-pna) and graphene-polyaniline (g-pani) modified electrode to detect human papillomavirus (hpv). an inkjet printing technique was employed to prepare the paper-based g-pani-modified working electrode. the aq-pna probe baring a negatively charged amino acid at the n-terminus was immobilized onto the electrode surface through electrostatic attraction. elec ... | 2017 | 28010840 |
| reactivation of latent hpv infections after renal transplantation. | female renal transplant recipients (rtrs) have an increased risk for developing human papillomavirus (hpv)-related (pre)malignant lesions of the genital tract. this study aims to assess the genital prevalence of hpv before and after renal transplantation (rt). in female patients who were counseled for rt at the radboud university medical center nijmegen, the netherlands, gynecological examination was performed at first visit, and 1 and 2 years later. hpv self-sampling and questionnaires on sexua ... | 2016 | 28009475 |
| association between toll-like receptor and tumor necrosis factor immunological pathways in uterine cervical neoplasms. | the immune system plays a critical role in the defense against human papillomavirus (hpv) infection and its persistence. toll-like receptors (tlrs) are membrane receptors responsible for activation of the innate immune response, and an association between tlr expression and uterine cervical cancer has been shown. tumor necrosis factors (tnfs) are among the main mediators of skin and mucosa inflammation. the aim of this study was to demonstrate the association between tlr and tnf immune expression ... | 2017 | 28009429 |
| immunotherapy against cancer-related viruses. | approximately 12% of all cancers worldwide are associated with viral infections. to date, eight viruses have been shown to contribute to the development of human cancers, including epstein-barr virus (ebv), hepatitis b and c viruses, and human papilloma virus, among others. these dna and rna viruses produce oncogenic effects through distinct mechanisms. first, viruses may induce sustained disorders of host cell growth and survival through the genes they express, or may induce dna damage response ... | 2017 | 28008927 |
| outcomes of surgically treated human papillomavirus-related oropharyngeal squamous cell carcinoma with n3 disease. | to evaluate outcomes for patients with pathological n3 (pn3) neck disease from human papillomavirus (hpv)-related oropharyngeal squamous cell carcinoma (opscc) and determine variables predictive of survival. | 2016 | 28008626 |
| development of a novel multiplex type-specific quantitative real-time pcr for detection and differentiation of infections with human papillomavirus types hpv2, hpv27, and hpv57. | the present study describes the development and evaluation of the first multiplex type-specific quantitative real-time pcr (rt-pcr), enabling simple, rapid, sensitive, and specific concurrent detection and differentiation of human papillomavirus (hpv) types hpv2, 27, and 57 in a single pcr reaction. | 2016 | 28006878 |
| identification of human papillomavirus (hpv) 16 dna integration and the ensuing patterns of methylation in hpv-associated head and neck squamous cell carcinoma cell lines. | recent studies showed that human papillomavirus (hpv) integration contributes to the genomic instability seen in hpv-associated head and neck squamous cell carcinoma (hpv-hnscc). however, the epigenetic alterations induced after hpv integration remains unclear. to identify the molecular details of hpv16 dna integration and the ensuing patterns of methylation in hnscc, we performed next-generation sequencing using a target-enrichment method for the effective identification of hpv16 integration br ... | 2017 | 28006857 |
| epidemiologic evaluation of human papillomavirus type competition and the potential for type replacement post-vaccination. | millions of women have been vaccinated with one of two first-generation human papillomavirus (hpv) vaccines. both vaccines remain in use and target two oncogenic types (hpvs 16 and 18); however, if these types naturally compete with others that are not targeted, type replacement may occur following reductions in the circulating prevalence of targeted types. to explore the potential for type replacement, we evaluated natural hpv type competition in unvaccinated females. | 2016 | 28005904 |
| trends in net survival from head and neck cancer in six european latin countries: results from the sudcan population-based study. | the aim of the sudcan collaborative study was to compare the trends in 1- and 5-year net survival and the trends in the dynamics of the excess mortality rates in head and neck cancers between six european latin countries (belgium, france, italy, portugal, spain and switzerland). the data were extracted from the eurocare-5 database. first, the net survival was studied over the 2000-2004 period using the pohar-perme estimator. for trend analyses, the study period was specific to each country. the ... | 2017 | 28005601 |
| the de and fg loops of the hpv major capsid protein contribute to the epitopes of vaccine-induced cross-neutralising antibodies. | the human papillomavirus (hpv) vaccines consist of major capsid protein (l1) virus-like particles (vlp) and are highly efficacious against the development of cervical cancer precursors attributable to oncogenic genotypes, hpv16 and hpv18. a degree of vaccine-induced cross-protection has also been demonstrated against genetically-related genotypes in the alpha-7 (hpv18-like) and alpha-9 (hpv16-like) species groups which is coincident with the detection of l1 cross-neutralising antibodies. in this ... | 2016 | 28004837 |
| mothers' intentions to vaccinate their teenaged children against human papillomavirus, as predicted by sex in south korea: an application of the theory of planned behavior. | this study was conducted in order to examine the intention of mothers to vaccinate their teenaged children against human papillomavirus (hpv) infection, according to the children's sex. based on the theory of planned behavior, the study identified the sex-specific predictors of mothers' intention to vaccinate their teenaged children against hpv. | 2016 | 28004510 |
| safety and immunogenicity study of a 9-valent human papillomavirus vaccine administered to 9-to-15 year-old japanese girls. | a 9-valent human papillomavirus (hpv 6/11/16/18/31/33/45/52/58) virus-like particle (vlp) vaccine (9vhpv) has been proven highly efficacious in preventing anogenital disease related with vaccine hpv types in a pivotal phase iii study in women aged 16 to 26 years. we report here the results of an open-label phase iii study conducted to bridge the findings in women age 16 to 26 years to japanese girls aged 9 to 15 years. all subjects (n = 100) received a 3-dose regimen of 9vhpv vaccine at day 1, m ... | 2016 | 28003597 |
| clinical updates in women's health care summary: liver disease: reproductive considerations. | all women are at risk of acute and chronic liver diseases. of particular importance are those diseases that exclusively affect pregnant women and have adverse effects on maternal, fetal, or neonatal outcomes. acute viral hepatitis is an important cause of liver disease in pregnant women, and hepatitis e infection is associated with substantial mortality. an increasing number of women have chronic liver diseases caused by viral hepatitis, alcoholic liver disease and nonalcoholic fatty liver disea ... | 2017 | 28002308 |
| hpv knowledge and vaccination rates in college-aged males: implications for practice. | human papillomavirus (hpv) is the most common sexually transmitted infection in the united states and is linked to anogenital cancers. college-aged males are at high risk for contracting hpv due to a lack of hpv knowledge and low vaccination rates. nps are responsible for providing this education and in return can help reduce infection transmission. | 2017 | 28002145 |
| use of visual inspection with acetic acid, pap smear, or high-risk human papillomavirus testing in women living with hiv/aids for posttreatment cervical cancer screening: same tests, different priorities. | few studies have addressed optimal follow-up for hiv-infected women after cervical treatment. this study aimed to compare performance of three available tests to detect posttreatment cervical disease in hiv-infected women in kenya. | 2017 | 28002084 |
| immuno-stimulating peptide derived from hmgb1 is more effective than the n-terminal domain of gp96 as an endogenous adjuvant for improvement of protein vaccines. | up to now, different protein vaccine modalities against human papillomavirus (hpv) have been designed to control cervical cancer. the important issue is to increase their immunogenicity using appropriate adjuvants. among heat shock proteins (hsps), glycoprotein 96 (gp96) and its n-terminal region (nt-gp96) have attracted a specific interest in stimulation of antigen-specific immune responses in vivo. furthermore, the potency of high mobility group box 1 (hmgb1) protein and its fragment (hp91) wa ... | 2016 | 28000571 |
| p16(ink4) expression is of prognostic and predictive value in oropharyngeal cancers independent of human papillomavirus status: a hungarian study. | head and neck cancer treatment protocols still lack well-established biomarkers of prognostic and predictive value. it is well known that human papillomavirus (hpv)-related and non-hpv-related oropharyngeal cancers are distinct entities concerning tumor biology and clinical outcome. however, there is an ongoing debate whether tumor suppressor p16(ink4) status alone or both p16(ink4) and hpv detection should be used in clinical settings. the aim of this study was to investigate p16(ink4)-immunola ... | 2017 | 27999998 |
| a pilot study on hla-g locus control region haplotypes and cervical intraepithelial neoplasias. | human papillomavirus (hpv) can induce cervical intraepithelial neoplasias (cin) grades 1, 2 and 3. untreated, these lesions may progress to cervical cancer (cc) which is the third most common cancer in women worldwide. hla-g plays an immunotolerant role in the immune response. the aim of this study was to characterize the configuration of snps located at the distal promoter of hla-g in patients with cin2 and cin3 and control women. the study sample was composed of 207 women as follows: 73 diagno ... | 2017 | 27998803 |
| zinc induces apoptosis on cervical carcinoma cells by p53-dependent and -independent pathway. | there is evidence that the mineral zinc is involved in the apoptotic cell death of various carcinoma cells. in this study, we aim to determine whether zinc in the form of cizar induces apoptosis in cervical carcinoma cells by increasing intracellular zinc concentration. | 2017 | 27998772 |
| human papillomavirus vaccine approval in china: a major step forward but challenges ahead. | 2016 | 27998583 | |
| [association between human papillomavirus infection and lung cancer]. | objective: to investigate the association between human papillomavirus (hpv) and lung cancer. methods: we examined a series of 83 lung cancer patients with hpv dna in both lung tumor specimens and adjacent normal specimens from fujian province. twenty-one of the most clinically relevant hpv types from the highly conserved l1 region of the viral genome were analyzed, using the pcr amplification and were followed by reverse hybridization with specific probes. chi-square test of paired design was u ... | 2016 | 27998417 |
| controlled hybrid-assembly of hpv16/18 l1 bi vlps in vitro. | based on the helix4-exchanged hpv16 l1 and hpv18 l1, hpv16 l1 bi and hpv18 l1 bi, we have successfully realized the controlled hybrid-assembly of hpv16/18 l1 bi vlps (bihybrid-vlps) in vitro. the bihybrid-vlps were further confirmed by fluorescence resonance energy transfer (fret) and complex-immunoprecipitation (co-ip) assays. the ratio of 16 l1 bi and 18 l1 bi in bihybrid-vlps was verified to be 3:5 based on a modified magnetic co-ip procedure, when mixing 1 equiv pentamer in assembly buffer s ... | 2016 | 27998118 |
| efficacy, immunogenicity, and safety of the hpv-16/18 as04-adjuvanted vaccine in chinese women aged 18-25 years: event-triggered analysis of a randomized controlled trial. | we previously reported the results of a phase ii/iii, double-blind, randomized controlled study in chinese women (nct00779766) showing a 94.2% (95% confidence interval: 62.7-99.9) hpv-16/18 as04-adjuvanted vaccine efficacy (ve) against cervical intraepithelial neoplasia grade 1 or higher (cin1+) and/or 6-month (m) persistent infection (pi) with a mean follow-up of <2 years, and immunogenicity until 7 months post-dose 1. here, we report efficacy and safety results from an event-triggered analysis ... | 2017 | 27998015 |
| cervical cancer screening with human papillomavirus dna and cytology in japan. | the aim of this study was to determine the value of human papillomavirus (hpv) testing for primary cervical cancer screening in japan. | 2017 | 27997455 |
| [treatment of oropharyngeal cancer human papillomavirus positive]. | 2016 | 27996223 | |
| a functional polymorphism in the nkg2d gene modulates nk-cell cytotoxicity and is associated with susceptibility to human papilloma virus-related cancers. | human papillomavirus (hpv) is the most common sexually transmitted agent worldwide and is etiologically linked to several cancers, including cervical and genital cancers. nkg2d, an activating receptor expressed by nk cells, plays an important role in cancer immune-surveillance. we analyzed the impact of a nkg2d gene variant, rs1049174, on the incidence of hpv-related cancers in vietnamese patients and utilized various molecular approaches to elucidate the mechanisms of nkg2d receptor regulation ... | 2016 | 27995954 |
| prevalence and severity of ocular surface neoplasia in african nations and need for early interventions. | ocular surface squamous neoplasia (ossn) is a common ocular surface tumor with an increased incidence in african countries (3.4 and 3.0 cases/year/100,000). despite its potential for vision loss and death, ossn remains largely neglected by both eye and hiv care programs in africa. the purpose of this review is to identify the barriers to timely diagnosis and early interventions for ossn in africa. pubmed searches were conducted targeting previous use of topical chemotherapy (interferon alpha 2b, ... | 2017 | 27994810 |
| interferon-tau has antiproliferative effects, represses the expression of e6 and e7 oncogenes, induces apoptosis in cell lines transformed with hpv16 and inhibits tumor growth in vivo. | interferon tau (ifn-τ) is a promising alternative antiviral and immunotherapeutic agent in a wide variety of diseases including infectious, neurodegenerative, autoimmune and cancer due to its low toxicity in comparison with other type i interferon´s. the objective of our study was established the effect of the bovine ifn-τ on human (siha) and murine (bmk-16/myc) cells transformed with hpv 16 and evaluates the antitumor effect in a murine tumor model hpv 16 positive. we determine that bovine ifn- ... | 2016 | 27994659 |
| misdiagnosis analysis of cervical minimal deviation adenocarcinoma: a report of three rare cases and literature review. | cervical minimal deviation adenocarcinoma (mda) is a rare variant of cervical adenocarcinoma that is difficult to diagnose due to the deep location, endogenous growth pattern, deceptively benign appearance of tumor cells, and lack of connection to human papillomavirus (hpv). cytological evaluation and biopsies offer suboptimal detection and transvaginal sonography or magnetic resonance imaging (mri) only reveal multiple lesions that mimic multiple benign nabothian cysts. besides, standard screen ... | 2016 | 27993884 |
| molecular approaches target to immunotherapy for hpv-associated cancers. | infection with human papillomavirus (hpvs) causes many cancers, which account for about 10-20% of total human cancers. two recently developed prophylactic vaccines against virus infection confer strong immunogenicity to provide long-term protection. the use of these vaccines has contributed to a substantial decrease in the rates of cervical cancer the second most common cancer of women worldwide. however, therapeutic vaccines that can eliminate pre-existing hpv infections and treat an existing h ... | 2016 | 27993116 |
| association between high risk human papillomavirus infection and co-infection with candida spp. and trichomonas vaginalis in women with cervical premalignant and malignant lesions. | human papillomavirus (hpv) is the necessary cause of cervical cancer. cervico-vaginal infection with pathogens like chlamydia is a likely cofactor. the interactions between hpv, trichomonas vaginalis (tv) and candida spp. are less understood, though inflammation induced by these pathogens has been demonstrated to facilitate oncogenesis. | 2017 | 27992790 |
| cervical human papillomavirus infection in the early postoperative period after liver transplantation: prevalence, risk factors, and concordance with anal infections. | solid organ transplant recipients are at increased risk of developing several human papillomavirus (hpv)-related malignancies, including cervical and anal cancers. the purpose of this prospective study was to assess the initial prevalence and risk factors for high-risk hpv (hr-hpv) cervical infections in liver transplant recipients, as well as their concordance with anal infections. a total of 50 female patients were enrolled in the department of general, transplant and liver surgery at the medi ... | 2017 | 27988990 |
| aptima hpv assay versus hybrid capture(®) 2 hpv test for primary cervical cancer screening in the hpv focal trial. | cervical cancer screening programs are switching from pap screening to high-risk hpv testing. | 2017 | 27988420 |
| how to get cost-effectiveness analysis right? the case of vaccine economics in latin america. | in middle-income countries, vaccines against pneumococcal disease, rotavirus, and human papilloma virus are in general more costly, not necessarily cost saving, and less consistently cost-effective than earlier generation vaccines against measles, diphtheria, tetanus, and pertussis. budget impact is also substantial; public spending on vaccines in countries adopting new vaccines is, on average, double the amount of countries that have not adopted. policymakers must weigh the costs and benefits o ... | 2016 | 27987640 |
| human papillomavirus regulates her3 expression in head and neck cancer: implications for targeted her3 therapy in hpv(+) patients. | purpose: human papillomavirus (hpv) 16 plays an etiologic role in a growing subset of head and neck squamous cell carcinomas (hnscc), where viral expression of the e6 and e7 oncoproteins is necessary for tumor growth and maintenance. although patients with hpv(+) tumors have a more favorable prognosis, there are currently no hpv-selective therapies. recent studies identified differential receptor tyrosine kinase (rtk) profiles in hpv(+) versus hpv(-) tumors. one such rtk, her3, is overexpressed ... | 2016 | 27986750 |
| the effect of intrauterine devices on acquisition and clearance of human papillomavirus. | previous studies have shown a decrease in cervical cancer associated with intrauterine device use. it has been hypothesized that intrauterine device use may alter the natural history of human papillomavirus infections, preempting development of precancerous lesions of the cervix and cervical cancer, but the effect of intrauterine devices on the natural history of human papillomavirus infection and subsequent development of cervical cancer is poorly understood. | 2017 | 27986460 |
| human papillomavirus infection status of various laryngeal diseases in japan: a comprehensive study. | the aim of our study was to clarify the human papillomavirus (hpv) infection status of various laryngeal diseases in tokyo, japan. | 2016 | 27986378 |
| subgroup analysis according to human papillomavirus status and tumor site of a randomized phase ii trial comparing cetuximab and cisplatin combined with radiation therapy for locally advanced head and neck cancer. | we report a subgroup analysis primarily focused on human papillomavirus (hpv)-related oropharyngeal cancer (opc) from the cetuximab plus radiotherapy versus cisplatin plus radiotherapy in locally advanced head and neck cancer (ctxmab+rt; clinicaltrials.gov identifier nct01216020) trial comparing radiation therapy with concomitant cisplatin (cddp) versus concomitant cetuximab (ctx) as first-line treatment of locally advanced head and neck cancer. | 2017 | 27986347 |
| cost-effectiveness study of hpv vaccination as a primary prevention strategy for anal cancer in hiv-positive men in chile. | most anal cancers are caused by the human papilloma virus (hpv) infection. the incidence is increasing, especially in high-risk individuals such as hiv-positive men. evidence shows that the new quadrivalent hpv vaccine reduces the rates of anal intraepithelial neoplasia among men who have sex with men. | 2016 | 27986194 |
| the toxicity and efficacy of concomitant chemoradiotherapy in patients aged 70 years and older with oropharyngeal carcinoma in the intensity-modulated radiotherapy era. | despite controversy surrounding its benefit, the use of concomitant chemoradiotherapy (ccrt) in patients with oropharyngeal squamous cell carcinoma (opscc) who are aged > 70 years is increasing. however, to the authors' knowledge, few studies to date have compared the outcomes of different systemic treatments in this population. | 2017 | 27984656 |
| cruising the cellular highways: how human papillomavirus travels from the surface to the nucleus. | the non-enveloped human papillomaviruses (hpvs) specifically target epithelial cells of the skin and mucosa. successful infection requires a lesion in the stratified tissue for access to the basal cells. herein, we discuss our recent progress in understanding binding, internalization, uncoating, and intracellular trafficking of hpv particles. our focus will be on hpv type 16, which is the most common hpv type associated with various anogenital and oropharyngeal carcinomas. the study of hpv entry ... | 2017 | 27984059 |
| how often people google for vaccination: qualitative and quantitative insights from a systematic search of the web-based activities using google trends. | nowadays, more and more people surf the internet seeking health-related information. information and communication technologies (icts) can represent an important opportunities in the field of public health and vaccinology. the aim of our current research was to investigate a) how often people search the internet for vaccination-related information, b) if this search is spontaneous or induced by media, and c) which kind of information is in particular searched. we used google trends (gt) for moni ... | 2017 | 27983896 |
| using qualitative methods to develop a contextually tailored instrument: lessons learned. | to develop a population-specific instrument to inform hepatitis b virus (hbv) and human papilloma virus (hpv) prevention education and intervention based on data and evidence obtained from the targeted population of khmer mothers reflecting their socio-cultural and health behaviors. | 2017 | 27981114 |
| human papillomavirus genotypes and hpv-16 variants distribution among tunisian women with normal cytology and squamous intraepithelial lesions. | little is known about the epidemiological characteristics of papillomavirus (hpv) infection among north african countries. herein, we conducted a molecular epidemiological study to investigate prevalence of hpv type and hpv-16 variants among cervical-screened unvaccinated tunisian women. | 2016 | 27980608 |
| ten years of anti-hpv vaccinations: what do we know? | human papillomavirus (hpv) is one of the most important carcinogens in humans. vaccines against hpv are now considered the first anti-cancer vaccinations. since 2007, in many developed countries, there have been recommendations present for preventive vaccines against hpv. at present, the degree of implementation of these recommendations depends on a number of country-specific factors such as the health care system organization or the ways of funding. hpv vaccines are primarily to prevent the dev ... | 2016 | 27980529 |
| tennessee's 3-star report: using available data systems to reduce missed opportunities to vaccinate preteens. | all preteens should receive tetanus-diphtheria-pertussis vaccine (tdap), quadrivalent meningococcal vaccine (men-acwy), and the human papillomavirus (hpv) cancer vaccine series. in tennessee, hpv vaccination rates have stagnated at low levels for a decade. three fundamental strategies to reduce missed opportunities for immunization include administering all recommended vaccines at the same visit, making strong recommendations for vaccines, and auditing and feedback. in tennessee, during each sum ... | 2016 | 27980415 |
| cross sectional study investigating the differences in knowledge and behaviors about hpv between vaccinated and non-vaccinated girls. | the aim of the presents study was to compare the level of knowledge about human papilloma virus (hpv) in vaccinated and non-vaccinated girls and to highlight the reasons why non-vaccinated girls refuse vaccination. | 2016 | 27980375 |
| analysis of sequence variation and risk association of human papillomavirus 52 variants circulating in korea. | human papillomavirus (hpv) 52 is a carcinogenic, high-risk genotype frequently detected in cervical cancer cases from east asia, including korea. | 2016 | 27977741 |
| use of a 2-dose schedule for human papillomavirus vaccination - updated recommendations of the advisory committee on immunization practices. | vaccination against human papillomavirus (hpv) is recommended to prevent hpv infections and hpv-associated diseases, including cancers. routine vaccination at age 11 or 12 years has been recommended by the advisory committee on immunization practices (acip) since 2006 for females and since 2011 for males (1,2). this report provides recommendations and guidance regarding use of hpv vaccines and updates acip hpv vaccination recommendations previously published in 2014 and 2015 (1,2). this report i ... | 2016 | 27977643 |
| preinvasive and invasive cervical adenocarcinoma: preceding low-risk or negative pap result increases time to diagnosis. | the aims of the study were to investigate screening histories of women with adenocarcinoma in situ (ais) and adenocarcinoma (adca) of the cervix and to further evaluate screening for glandular disease. | 2017 | 27977543 |
| ce: human papillomavirus-related oral cancers: the nurse's role in mitigating stigma and dispelling myths. | frank discussion is essential to both treatment and prevention. | 2016 | 27977435 |
| weak selectivity predicted for modeled bundles of viral channel-forming protein e5 of human papillomavirus-16. | protein e5 is a polytopic 83 amino acid membrane protein with three transmembrane domains (tmds), encoded by high-risk human papillomavirus-16 (hpv-16). hpv-16 is found to be the causative agent for cervical cancer. protein e5, among other proteins (e.g., e6, e7), is expressed at an "early" (e) stage when the cell turns malignant. it has been experimentally found that e5 forms hexameric assemblies, which show the characteristics of the class of so-called channel-forming proteins by rendering lip ... | 2016 | 27976908 |
| surgical management of giant genital condyloma acuminata by using double keystone flaps. | condyloma acuminata in the external genitalia (genital warts) is a sexually transmitted disease that is often caused by human papillomavirus (hpv). we report a case of giant genital condyloma acuminata in a 35-year-old male patient with hiv comorbidity treated by wide surgical excision. excision defect was covered with split thickness skin graft (stsg) and double keystone flaps. there was no complication after surgery. ten months following surgery, there was no new condyloma lesion and the patie ... | 2016 | 27974988 |
| universal human papillomavirus typing assay: whole-genome sequencing following target enrichment. | we designed a universal human papillomavirus (hpv) typing assay based on target enrichment and whole-genome sequencing (ewgs). the rna bait included 23,941 probes targeting 191 hpv types and 12 probes targeting beta-globin as a control. we used the agilent sureselect xt2 protocol for library preparation, illumina hiseq 2500 for sequencing, and clc genomics workbench for sequence analysis. mapping stringency for type assignment was determined based on 8 (6 hpv-positive and 2 hpv-negative) control ... | 2017 | 27974548 |
| high rates of anal high-grade squamous intraepithelial lesions in hiv-infected women who do not meet screening guidelines. | human immunodeficiency virus (hiv)-infected women have a higher burden of anal high-grade squamous intraepithelial lesions (hsil) and anal cancer (ac) compared with hiv-uninfected women. guidelines for ac screening in this population are heterogeneous. here we report outcomes and risk factors for anal hsil following implementation of universal ac screening offered to all hiv-infected women. | 2017 | 27965301 |
| involvement of brd4 in different steps of the papillomavirus life cycle. | bromodomain-containing protein 4 (brd4) is a cellular chromatin-binding factor and transcriptional regulator that recruits sequence-specific transcription factors and chromatin modulators to control target gene transcription. papillomaviruses (pvs) have evolved to hijack brd4's activity in order to create a facilitating environment for the viral life cycle. brd4, in association with the major viral regulatory protein e2, is involved in multiple steps of the pv life cycle including replication in ... | 2017 | 27965149 |