Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| long-term two-photon calcium imaging of neuronal populations with subcellular resolution in adult non-human primates. | two-photon imaging with genetically encoded calcium indicators (gecis) enables long-term observation of neuronal activity in vivo. however, there are very few studies of gecis in primates. here, we report a method for long-term imaging of a geci, gcamp6f, expressed from adeno-associated virus vectors in cortical neurons of the adult common marmoset (callithrix jacchus), a small new world primate. we used a tetracycline-inducible expression system to robustly amplify neuronal gcamp6f expression a ... | 2015 | 26655910 |
| endocrine and cognitive adaptations to cope with stress in immature common marmosets (callithrix jacchus): sex and age matter. | phenotypic sex differences in primates are associated with body differentiation during the early stages of life, expressed in both physiological and behavioral features. hormones seem to play a pivotal role in creating a range of responses to meet environmental and social demands, resulting in better reactions to cope with challenges to survival and reproduction. steroid hormones actively participate in neuroplasticity and steroids from both gonads and neurons seem to be involved in behavioral m ... | 2015 | 26648876 |
| α-synuclein aggregation in the olfactory bulb of middle-aged common marmoset. | the synaptic protein α-synuclein has been identified as a major component of lewy bodies, a pathological hallmark of parkinson's disease (pd). prior to the formation of lewy bodies, mislocalization and aggregation of the α-synuclein in brain tissue is frequently observed in various neurodegenerative diseases. aberrant accumulation and localization of α-synuclein are also observed in the aging human brain, for which reason aging is regarded as a risk factor for neurodegenerative disease. to inves ... | 2016 | 26643383 |
| flibanserin-stimulated partner grooming reflects brain metabolism changes in female marmosets. | female sexual interest and arousal disorder is personally distressing for women. to better understand the mechanism of the candidate therapeutic, flibanserin, we determined its effects on an index of brain glucose metabolism. | 2015 | 26635207 |
| a quantitative acoustic analysis of the vocal repertoire of the common marmoset (callithrix jacchus). | the common marmoset (callithrix jacchus), a highly vocal new world primate species, has emerged in recent years as a promising animal model for studying brain mechanisms underlying perception, vocal production, and cognition. the present study provides a quantitative acoustic analysis of a large number of vocalizations produced by marmosets in a social environment within a captive colony. previous classifications of the marmoset vocal repertoire were mostly based on qualitative observations. in ... | 2015 | 26627765 |
| resequencing of the common marmoset genome improves genome assemblies and gene-coding sequence analysis. | the first draft of the common marmoset (callithrix jacchus) genome was published by the marmoset genome sequencing and analysis consortium. the draft was based on whole-genome shotgun sequencing, and the current assembly version is callithrix_jacches-3.2.1, but there still exist 187,214 undetermined gap regions and supercontigs and relatively short contigs that are unmapped to chromosomes in the draft genome. we performed resequencing and assembly of the genome of common marmoset by deep sequenc ... | 2015 | 26586576 |
| metabolic characterization of the common marmoset (callithrix jacchus). | high-resolution metabolomics has created opportunity to integrate nutrition and metabolism into genetic studies to improve understanding of the diverse radiation of primate species. at present, however, there is very little information to help guide experimental design for study of wild populations. in a previous non-targeted metabolomics study of common marmosets (callithrix jacchus), rhesus macaques, humans, and four non-primate mammalian species, we found that essential amino acids (aa) and o ... | 2015 | 26581102 |
| metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (callithrix jacchus). | rapamycin has been shown to extend lifespan in rodent models, but the effects on metabolic health and function have been widely debated in both clinical and translational trials. prior to rapamycin being used as a treatment to extend both lifespan and healthspan in the human population, it is vital to assess the side effects of the treatment on metabolic pathways in animal model systems, including a closely related non-human primate model. in this study, we found that long-term treatment of marm ... | 2015 | 26568298 |
| connectivity between the off bipolar type db3a and six types of ganglion cell in the marmoset retina. | parallel visual pathways originate at the first synapse in the retina, where cones make connections with cone bipolar cells that in turn contact ganglion cells. there are more ganglion cell types than bipolar types, suggesting that there must be divergence from bipolar to ganglion cells. here we analyze the contacts between an off bipolar type (db3a) and six ganglion cell types in the retina of the marmoset monkey (callithrix jacchus). ganglion cells were transfected via particle-mediated gene t ... | 2016 | 26559914 |
| scratching under positive and negative arousal in common marmosets (callithrix jacchus). | scratching has been widely used as an indicator of anxiety in many primate species. however, a handful of studies have shown no change in scratching under anxiety-provoking circumstances. in addition, the existing literature has investigated scratching only in relation to negative arousal (i.e., anxiety), even though anxiety and excitement (positive arousal) share important physiological and behavioral correlates, including increased heart rate, blood pressure, and locomotion. in the current stu ... | 2016 | 26530306 |
| sphere-formation culture of testicular germ cells in the common marmoset, a small new world monkey. | spermatogonia are specialized cells responsible for continuous spermatogenesis and the production of offspring. because of this biological property, in vitro culture of spermatogonia provides a powerful methodology to advance reproductive biology and engineering. however, methods for culturing primate spermatogonia are poorly established. we have designed a novel method for culturing spermatogonia in the common marmoset (callithrix jacchus), a small primate. by using our method with a suite of g ... | 2016 | 26530217 |
| marmosets treated with oxytocin are more socially attractive to their long-term mate. | adult male-female bonds are partly characterized by initiating and maintaining close proximity with a social partner, as well as engaging in high levels of affiliative and sociosexual behavior. oxytocin (oxt), a neuromodulatory nonapeptide, plays a critical role in the facilitation of social bonding and prosocial behavior toward a social partner (feldman, 2012). however, less attention has been given to whether augmentation of oxt levels in an individual alters others' perceptions and behavior t ... | 2015 | 26528149 |
| cognitive impairment in a young marmoset reveals lateral ventriculomegaly and a mild hippocampal atrophy: a case report. | the number of studies that use the common marmoset (callithrix jacchus) in various fields of neurosciences is increasing dramatically. in general, animals enter the study when their health status is considered satisfactory on the basis of classical clinical investigations. in behavioral studies, variations of score between individuals are frequently observed, some of them being considered as poor performers or outliers. experimenters rarely consider the fact that it could be related to some brai ... | 2015 | 26527211 |
| bifidobacterium myosotis sp. nov., bifidobacterium tissieri sp. nov. and bifidobacterium hapali sp. nov., isolated from faeces of baby common marmosets (callithrix jacchus l.). | in a previous study on bifidobacterial distribution in new world monkeys, six strains belonging to the bifidobacteriaceae were isolated from faecal samples of baby common marmosets (callithrix jacchus l.). all the isolates were gram-positive-staining, anaerobic, asporogenous and fructose-6-phosphate phosphoketolase-positive. comparative analysis of 16s rrna gene sequences revealed relatively low levels of similarity (maximum identity 96 %) to members of the genus bifidobacterium, and placed the ... | 2016 | 26515885 |
| functional columns in superior temporal sulcus areas of the common marmoset. | cortical areas in the superior temporal sulcus (sts) of primates have been recognized as a part of the 'social brain'. in particular, biological motion stimuli elicit neuronal responses in the sts, indicating their roles in the ability to understand others' actions. however, the spatial organization of functionally identified sts cells is not well understood because it is difficult to identify the precise locations of cells in sulcal regions. here, using a small new world monkey, the common marm ... | 2015 | 26512934 |
| hiv-1 adapts to replicate in cells expressing common marmoset apobec3g and bst2. | previous studies have shown that a major block to hiv-1 replication in common marmosets operates at the level of viral entry and that this block can be overcome by adaptation of the virus in tissue-cultured cells. however, our current studies indicate that hiv-1 encounters additional postentry blocks in common marmoset peripheral blood mononuclear cells. here, we show that the common marmoset apobec3g (a3g) and bst2 proteins block hiv-1 in cell cultures. using a directed-evolution method that ta ... | 2015 | 26512082 |
| caffeine 7-n-demethylation and c-8-oxidation mediated by liver microsomal cytochrome p450 enzymes in common marmosets. | 1. 3-n-demethylation of caffeine (1,3,7-trimethylxanthine) is mediated by human cytochrome p450 1a2, whereas 7-n-demethylation and c-8-hydroxylation are reportedly catalyzed by monkey p450 2c9 and rat p450 1a2, respectively. 2. roles of marmoset p450 enzymes in caffeine oxidation were investigated using nine marmoset liver microsomes and 14 recombinantly expressed marmoset p450 enzymes. 3. predominant caffeine 7-n-demethylation and c-8-hydroxylation activities in marmoset liver microsomes were m ... | 2015 | 26503341 |
| molecular cloning, tissue distribution, and functional characterization of marmoset cytochrome p450 1a1, 1a2, and 1b1. | the common marmoset (callithrix jacchus), a new world monkey, has potential to be an animal model for drug metabolism studies. in this study, we identified and characterized cytochrome p450 (p450) 1a1 and 1b1 in addition to the known p450 1a2 in marmosets. marmoset p450 1a1 and 1b1 cdna contained open reading frames encoding 512 and 543 amino acids, respectively, with high sequence identities (90%-93%) to other primate p450 1a1s and 1b1s. a phylogenetic tree based on amino acid sequences showed ... | 2016 | 26502772 |
| neurobehavioral development of common marmoset monkeys. | common marmoset (callithrix jacchus) monkeys are a resource for biomedical research and their use is predicted to increase due to the suitability of this species for transgenic approaches. identification of abnormal neurodevelopment due to genetic modification relies upon the comparison with validated patterns of normal behavior defined by unbiased methods. as scientists unfamiliar with nonhuman primate development are interested to apply genomic editing techniques in marmosets, it would be bene ... | 2016 | 26502294 |
| expression and distribution of peroxiredoxins in the retina and optic nerve. | oxidative stress is implicated in various pathological conditions of the retina and optic nerve. peroxiredoxins (prdxs) comprise a recently characterized family of antioxidant enzymes. to date, little information exists regarding the distribution of prdxs in the eye. herein, we employed a combination of qrt-pcr, immunohistochemistry and western blotting to determine the level of expression and distribution of the six prdx isoforms in the retina and optic nerve of the rat. in addition, we perform ... | 2016 | 26501408 |
| can vocal conditioning trigger a semiotic ratchet in marmosets? | the complexity of human communication has often been taken as evidence that our language reflects a true evolutionary leap, bearing little resemblance to any other animal communication system. the putative uniqueness of the human language poses serious evolutionary and ethological challenges to a rational explanation of human communication. here we review ethological, anatomical, molecular, and computational results across several species to set boundaries for these challenges. results from anim ... | 2015 | 26500583 |
| active control of the nucleation temperature enhances freezing survival of multipotent mesenchymal stromal cells. | cryopreservation is a technique that has been extensively used for storage of multipotent mesenchymal stromal cells (mscs) in regenerative medicine. therefore, improving current cryopreservation procedures in terms of increasing cell viability and functionality is important. in this study, we optimized the cryopreservation protocol of mscs derived from the common marmoset callithrix jacchus (cj), which can be used as a non-human primate model in various pathological and transplantation studies a ... | 2015 | 26499840 |
| hormonal stimulation and paternal experience influence responsiveness to infant distress vocalizations by adult male common marmosets, callithrix jacchus. | parental experience and hormones play a large role in the common marmoset (callithrix jacchus) father's care of their offspring. we tested the effect of exogenous estradiol or testosterone on the responsiveness of common marmosets to respond to infant distress vocalizations and whether males who haven't become fathers yet (paired males) would have increased responsiveness to infant distress calls with either steroid or whether parental experience is the most important component for the onset of ... | 2016 | 26497409 |
| sustained performance by common marmosets in a delayed matching to position task with variable stimulus presentations. | working memory is used to solve various cognitive problems by maintaining information for some time and then by refreshing this information after certain purposes are achieved. in the present study, we explored the ability of common marmosets to perform a delayed matching to position (dmtp) task in a controlled environment using operant conditioning. the dmtp task requires the subjects to respond to the sample stimulus and to select one of two comparison stimuli with a position matching that of ... | 2016 | 26475508 |
| oxytocin and vasopressin enhance responsiveness to infant stimuli in adult marmosets. | the neuropeptides oxytocin (ot) and arginine-vasopressin (avp) have been implicated in modulating sex-specific responses to offspring in a variety of uniparental and biparental rodent species. despite the large body of research in rodents, the effects of these hormones in biparental primates are less understood. marmoset monkeys (callithrix jacchus) belong to a clade of primates with a high incidence of biparental care and also synthesize a structurally distinct variant of ot (proline instead of ... | 2015 | 26472596 |
| mismatch negativity in common marmosets: whole-cortical recordings with multi-channel electrocorticograms. | mismatch negativity (mmn) is a component of event-related potentials (erps) evoked by violations of regularity in sensory stimulus-series in humans. recently, the mmn has received attention as a clinical and translatable biomarker of psychiatric disorders such as schizophrenia, and for the development animal models of these psychiatric disorders. in this study, we investigated the generation of mmn in common marmosets, which are an important non-human primate model with genetic manipulability. w ... | 2015 | 26456147 |
| draft genome sequence of enteropathogenic escherichia coli, isolated from the bloody stool sample of a common marmoset (callithrix jacchus). | here, we report the draft genome sequence of escherichia coli strain r811. this bacterium was isolated from the bloody stool sample of a common marmoset, and was categorized as enteropathogenic e. coli because it possessed eae. | 2015 | 26450733 |
| serological evidence of infection by leishmania (leishmania) infantum (synonym: leishmania (leishmania) chagasi) in free-ranging wild mammals in a nonendemic region of the state of são paulo, brazil. | concerns about the interface between wildlife, domestic animals, and humans in the transmission of visceral leishmaniasis (vl) have been growing due to natural or anthropogenic environmental changes. in this context, investigations of the infection in wild mammals are important to assess their exposure to the vector and the parasite. a study of anti-leishmania (leishmania) infantum antibodies was carried out using the direct agglutination test (dat) on 528 free-ranging wild mammals of 38 species ... | 2015 | 26418884 |
| the adenosine a2a receptor antagonist, istradefylline enhances anti-parkinsonian activity induced by combined treatment with low doses of l-dopa and dopamine agonists in mptp-treated common marmosets. | the adenosine a2a receptor antagonist, istradefylline improves motor function in patients with advanced parkinson's disease (pd) optimally treated with a combination of l-dopa and a dopamine agonist without increasing the risk of troublesome dyskinesia. however, the effects of istradefylline on motor function when administered in combination with low dose of l-dopa and dopamine agonists as occurs in early pd are unknown. we investigated whether istradefylline enhances the combined anti-parkinson ... | 2015 | 26415982 |
| corticospinal tract tracing in the marmoset with a clinical whole-body 3t scanner using manganese-enhanced mri. | manganese-enhanced mri (memri) has been described as a powerful tool to depict the architecture of neuronal circuits. in this study we investigated the potential use of in vivo mri detection of manganese for tracing neuronal projections from the primary motor cortex (m1) in healthy marmosets (callithrix jacchus). we determined the optimal dose of manganese chloride (mncl2) among 800, 400, 40 and 8 nmol that led to manganese-induced hyperintensity furthest from the injection site, as specific to ... | 2015 | 26398500 |
| immune profile of an atypical eae model in marmoset monkeys immunized with recombinant human myelin oligodendrocyte glycoprotein in incomplete freund's adjuvant. | experimental autoimmune encephalomyelitis (eae) in the common marmoset monkey (callithrix jacchus) is a relevant preclinical model for translational research into immunopathogenic mechanisms operating in multiple sclerosis (ms). prior studies showed a core pathogenic role of t and b cells specific for myelin oligodendrocyte glycoprotein (mog). however, in those studies, the quality of the response against mog epitopes was strongly biased by bacterial antigens in the complete freund's adjuvant (c ... | 2015 | 26377397 |
| more effective induction of anesthesia using midazolam-butorphanol-ketamine-sevoflurane compared with ketamine-sevoflurane in the common marmoset monkey (callithrix jacchus). | the common marmoset has been increasingly used for research in the biomedical field; however, there is little information available regarding effective methods of anesthesia in this species. this study retrospectively analyzed 2 regimens of anesthesia induction: intramuscular injection of ketamine followed by inhalation of 5% sevoflurane, and intramuscular injection of midazolam, butorphanol and ketamine followed by inhalation of 5% sevoflurane. anesthetic depth did not reach the surgical anesth ... | 2016 | 26369292 |
| the temporal profile of retinal cell genesis in the marmoset monkey. | the new world marmoset monkey (callithrix jacchus) has a relatively short gestational period compared with other primates but possesses a retina at a similar stage of maturation by birth. previous studies have highlighted that the complex fovea of the marmoset undergoes a more rapid postnatal development in comparison with the macaca monkey, reaching a mature stage earlier than these species. in this current study, we examined the prenatal proliferation profile of cells in the entire retina empl ... | 2016 | 26355791 |
| intratracheal exposure of common marmosets to mers-cov jordan-n3/2012 or mers-cov emc/2012 isolates does not result in lethal disease. | middle east respiratory syndrome coronavirus (mers-cov) continues to be a threat to human health in the middle east. development of countermeasures is ongoing; however, an animal model that faithfully recapitulates human disease has yet to be defined. a recent study indicated that inoculation of common marmosets resulted in inconsistent lethality. based on these data we sought to compare two isolates of mers-cov. we followed disease progression in common marmosets after intratracheal exposure wi ... | 2015 | 26342468 |
| isolation and characterization of a novel helicobacter species, helicobacter jaachi sp. nov., from common marmosets (callithrix jaachus). | purpose-bred common marmosets from domestic sources housed in a us research facility, and used in multiple drug discovery programmes, were noted to have a high incidence of spontaneous inflammatory bowel disease and sporadic cholecystitis and cholangiohepatitis. inflammatory infiltrates increased in incidence and severity with age. because helicobacter spp. have been linked to gastrointestinal diseases, samples from the gastrointestinal tracts of 39 marmosets were screened for helicobacter spp. ... | 2015 | 26297446 |
| molecular and cellular characteristics of human and non-human primate multipotent stromal cells from the amnion and bone marrow during long term culture. | multipotent stromal cells (mscs) are among the key candidates in regenerative medicine. however variety of msc sources and general heterogeneity lead to controversial data in functional characterization. furthermore, despite intensive usage as preclinical animal model, little is known about mscs of the common marmoset monkey. | 2015 | 26297012 |
| blockade of cd127 exerts a dichotomous clinical effect in marmoset experimental autoimmune encephalomyelitis. | non-human primate models of human disease have an important role in the translation of a new scientific finding in lower species into an effective treatment. in this study, we tested a new therapeutic antibody against the il-7 receptor α chain (cd127), which in a c57bl/6 mouse model of experimental autoimmune encephalomyelitis (eae) ameliorates disease, demonstrating an important pathogenic function of il-7. we observed that while the treatment was effective in 100 % of the mice, it was only par ... | 2016 | 26260924 |
| tissue-specific expression pattern and histological distribution of nlrp3 in chinese yellow chicken. | pathogen-associated molecular patterns (pamps) play important role in inflammation which means response of the host to stimuli. nod-like receptor protein 3 (nlrp3) inflammasome is involved in the onset and development of inflammation. nlrp3, as one of the most important inflammasome sensors, has significant effect on the regulation of inflammasome activation to avoid the consequences of over activation. up to date, there are no detailed tissue specific expression and distribution data about nlpr ... | 2015 | 26246158 |
| striatal and extrastriatal dopamine release in the common marmoset brain measured by positron emission tomography and [(18)f]fallypride. | previous studies have demonstrated that patients with schizophrenia show greater sensitivity to psychostimulants than healthy subjects. sensitization to psychostimulants and resultant alteration of dopaminergic neurotransmission in rodents has been suggested as a useful model of schizophrenia. this study sought to examine the use of methylphenidate as a psychostimulant to induce dopamine release and that of [(18)f]fallypride as a radioligand to quantify the release in a primate model of schizoph ... | 2015 | 26232153 |
| strongly bonded family members in common marmosets show synchronized fluctuations in oxytocin. | oxytocin is a key regulator of social bonding and is positively linked to affiliation and prosocial behavior in several mammal species. in chimpanzees, this link is dyad-specific as affiliative interactions only elicit high oxytocin release if they involve strongly bonded individuals. these studies involved isolated dyads and sampling events. little is known about the role of oxytocin in affiliation and social bonding, and about potential long-term patterns of bonding-related and dyad-specific o ... | 2015 | 26232089 |
| high-performance metabolic profiling with dual chromatography-fourier-transform mass spectrometry (dc-ftms) for study of the exposome. | studies of gene-environment (g × e) interactions require effective characterization of all environmental exposures from conception to death, termed the exposome. the exposome includes environmental exposures that impact health. improved metabolic profiling methods are needed to characterize these exposures for use in personalized medicine. in the present study, we compared the analytic capability of dual chromatography-fourier-transform mass spectrometry (dc-ftms) to previously used liquid chrom ... | 2013 | 26229523 |
| novel marmoset cytochrome p450 2c19 in livers efficiently metabolizes human p450 2c9 and 2c19 substrates, s-warfarin, tolbutamide, flurbiprofen, and omeprazole. | the common marmoset (callithrix jacchus), a small new world monkey, has the potential for use in human drug development due to its evolutionary closeness to humans. four novel cdnas, encoding cytochrome p450 (p450) 2c18, 2c19, 2c58, and 2c76, were cloned from marmoset livers to characterize p450 2c molecular properties, including previously reported p450 2c8. the deduced amino acid sequence showed high sequence identities (>86%) with those of human p450 2cs, except for marmoset p450 2c76, which ... | 2015 | 26228688 |
| murine k2p5.1 deficiency has no impact on autoimmune neuroinflammation due to compensatory k2p3.1- and kv1.3-dependent mechanisms. | lymphocytes express potassium channels that regulate physiological cell functions, such as activation, proliferation and migration. expression levels of k2p5.1 (task2; kcnk5) channels belonging to the family of two-pore domain potassium channels have previously been correlated to the activity of autoreactive t lymphocytes in patients with multiple sclerosis and rheumatoid arthritis. in humans, k2p5.1 channels are upregulated upon t cell stimulation and influence t cell effector functions. howeve ... | 2015 | 26213925 |
| experimental respiratory infection of marmosets (callithrix jacchus) with ebola virus kikwit. | ebola virus (ebov) causes a highly infectious and lethal hemorrhagic fever in primates with high fatality rates during outbreaks and ebov may be exploited as a potential biothreat pathogen. there is therefore a need to develop and license appropriate medical countermeasures against this virus. to determine whether the common marmoset (callithrix jacchus) would be an appropriate model to assess vaccines or therapies against ebov disease (evd), initial susceptibility, lethality and pathogenesis st ... | 2015 | 26209682 |
| a new targeted model of experimental autoimmune encephalomyelitis in the common marmoset. | multiple sclerosis (ms) is the most common cause for sustained disability in young adults, yet treatment options remain very limited. although numerous therapeutic approaches have been effective in rodent models of experimental autoimmune encephalomyelitis (eae), only few proved to be beneficial in patients with ms. hence, there is a strong need for more predictive animal models. within the past decade, eae in the common marmoset evolved as a potent, alternative model for ms, with immunological ... | 2016 | 26207848 |
| middle east respiratory syndrome coronavirus efficiently infects human primary t lymphocytes and activates the extrinsic and intrinsic apoptosis pathways. | middle east respiratory syndrome (mers) is associated with a mortality rate of >35%. we previously showed that mers coronavirus (mers-cov) could infect human macrophages and dendritic cells and induce cytokine dysregulation. here, we further investigated the interplay between human primary t cells and mers-cov in disease pathogenesis. importantly, our results suggested that mers-cov efficiently infected t cells from the peripheral blood and from human lymphoid organs, including the spleen and th ... | 2016 | 26203058 |
| treatment with lopinavir/ritonavir or interferon-β1b improves outcome of mers-cov infection in a nonhuman primate model of common marmoset. | middle east respiratory syndrome coronavirus (mers-cov) causes severe disease in human with an overall case-fatality rate of >35%. effective antivirals are crucial for improving the clinical outcome of mers. although a number of repurposed drugs, convalescent-phase plasma, antiviral peptides, and neutralizing antibodies exhibit anti-mers-cov activity in vitro, most are not readily available or have not been evaluated in nonhuman primates. we assessed 3 repurposed drugs with potent in vitro anti- ... | 2015 | 26198719 |
| animal models of middle east respiratory syndrome coronavirus infection. | the emergence of the middle east respiratory syndrome coronavirus (mers-cov) in 2012 marked the second time that a new, highly pathogenic coronavirus has emerged in the human population in the 21st century. in this review, we discuss the current state of knowledge of animal models of mers-cov infection. commonly used laboratory animal species such as syrian hamsters, mice and ferrets are not susceptible to mers-cov, due to differences in the mers-cov receptor dipeptidyl peptidase 4 (dpp4). the i ... | 2015 | 26192750 |
| septo-temporal distribution and lineage progression of hippocampal neurogenesis in a primate (callithrix jacchus) in comparison to mice. | adult born neurons in the hippocampus show species-specific differences in their numbers, the pace of their maturation and their spatial distribution. here, we present quantitative data on adult hippocampal neurogenesis in a new world primate, the common marmoset (callithrix jacchus) that demonstrate parts of the lineage progression and age-related changes. proliferation was largely (∼70%) restricted to stem cells or early progenitor cells, whilst the remainder of the cycling pool could be assig ... | 2015 | 26175670 |
| pentatrichomonas hominis in laboratory-bred common marmosets. | trichomonadid protozoa have been found in the intestinal tracts of common marmosets (callithrix jacchus). however, there is little information available on species identification and the pathogenicity of these trichomonads. in this study, we conducted a fecal survey of a common marmoset colony maintained as laboratory animals in japan and identified the trichomonad species. screening using a fecal smear examination revealed that 66% (58/88) of the marmosets had trichomonadid trophozoites in thei ... | 2015 | 26156572 |
| a case of nontraumatic gas gangrene in a common marmoset (callithrix jacchus). | the common marmoset is widely used in neuroscience and regenerative medicine research. however, information concerning common marmoset disorders, particularly infectious diseases, is scarce. here, we report a case of a female common marmoset that died suddenly due to gas gangrene. the animal presented with gaseous abdominal distention at postmortem, and clostridium perfringens type a was isolated from several tissues. vacuoles, a gram-positive bacteremia and intravascular hemolysis were observed ... | 2016 | 26156080 |
| functional mri of visual responses in the awake, behaving marmoset. | the visual brain is composed of interconnected subcortical and cortical structures that receive and process image information originating in the retina. the visual system of nonhuman primates, in particular macaques, has been studied in great detail in order to elucidate principles of human sensation and perception. the common marmoset (callithrix jacchus) is a small new world monkey of growing interest as a primate model for neuroscience. marmosets have advantages over macaques because of their ... | 2015 | 26149609 |
| susceptibility of marmosets (callithrix jacchus) to monkeypox virus: a low dose prospective model for monkeypox and smallpox disease. | although current nonhuman primate models of monkeypox and smallpox diseases provide some insight into disease pathogenesis, they require a high titer inoculum, use an unnatural route of infection, and/or do not accurately represent the entire disease course. this is a concern when developing smallpox and/or monkeypox countermeasures or trying to understand host pathogen relationships. in our studies, we altered half of the test system by using a new world nonhuman primate host, the common marmos ... | 2015 | 26147658 |
| simultaneous pharmacokinetics evaluation of human cytochrome p450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (callithrix jacchus). | 1. pharmacokinetics of human cytochrome p450 probes (caffeine, racemic warfarin, omeprazole, metoprolol and midazolam) composite, after single intravenous and oral administrations at doses of 0.20 and 1.0 mg kg(-1), respectively, to four male common marmosets were investigated. 2. the plasma concentrations of caffeine and warfarin decreased slowly in a monophasic manner but those of omeprazole, metoprolol and midazolam decreased extensively after intravenous and oral administrations, in a manner ... | 2016 | 26114209 |
| histological and electrophysiological analysis of the corticospinal pathway to forelimb motoneurons in common marmosets. | using histological and electrophysiological methods, we identified the neuroanatomical properties of the common marmoset corticospinal tract (cst), which underlies hand/arm motor control. biotinylated dextran amine (bda) was injected into the primary motor cortex to anterogradely label cst axons in the cervical segments, revealing that most cst axons descend in the contralateral dorsolateral funiculus (dlf; 85.0%), and some in the ipsilateral dlf (10.7%). terminal buttons were mainly found in th ... | 2015 | 26093181 |
| high-field functional magnetic resonance imaging of vocalization processing in marmosets. | vocalizations are behaviorally critical sounds, and this behavioral importance is reflected in the ascending auditory system, where conspecific vocalizations are increasingly over-represented at higher processing stages. recent evidence suggests that, in macaques, this increasing selectivity for vocalizations might culminate in a cortical region that is densely populated by vocalization-preferring neurons. such a region might be a critical node in the representation of vocal communication sounds ... | 2015 | 26091254 |
| production of a high-affinity monoclonal antibody reactive with folate receptors alpha and beta. | folate receptors α (frα) and β (frβ) are two isoforms of the cell surface glycoprotein that binds folate. the expression of frα is rare in normal cells and elevated in cancer cells. thus, frα-based tumor-targeted therapy has been a focus area of laboratory research and clinical trials. recently, it was shown that a significant fraction of tumor-associated macrophages expresses frβ and that these cells can enhance tumor growth. although frα and frβ share 70% identity in their deduced amino acid s ... | 2015 | 26090596 |
| complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex. | cadherin is a cell adhesion molecule widely expressed in the nervous system. previously, we analyzed the expression of nine classic cadherins (cdh4, cdh6, cdh7, cdh8, cdh9, cdh10, cdh11, cdh12, and cdh20) and t-cadherin (cdh13) in the developing postnatal common marmoset (callithrix jacchus) brain, and found differential expressions between mice and marmosets. in this study, to explore primate-specific cadherin expression at the embryonic stage, we extensively analyzed the expression of these ca ... | 2015 | 26081465 |
| bone disease in the common marmoset: radiographic and histological findings. | the common marmoset (callithrix jacchus) is a new world primate that is used in biomedical research due to its small size and relative ease of handling compared with larger primates. although bone disease in common marmosets is well recognized, there are very few detailed descriptions in the literature that cover the range of lesions seen in these animals. for all animals used to model human disease, it is important to be aware of background lesions that may affect the interpretation of study fi ... | 2015 | 26077785 |
| behavioral and trait rating assessments of personality in common marmosets (callithrix jacchus). | the study of personality in animals is a rapidly growing scientific field and numerous species have been reported to show consistent personality profiles. much animal personality research has focused on nonhuman primates, with the main emphasis being placed on old world primates, particularly rhesus macaques and chimpanzees. so far, little work has been done on cooperatively breeding nonhuman primates and new world species. here, we study personality in the cooperatively breeding common marmoset ... | 2015 | 26075516 |
| improved hematopoietic differentiation of primate embryonic stem cells by inhibition of the pi3k-akt pathway under defined conditions. | hematopoietic stem/progenitor cells (hspcs) derived from embryonic stem cells (escs) and induced pluripotent stem cells (ipscs) have potential therapeutic applications in humans. to assess the safety and efficacy of esc/ipsc-based therapies, reliable animal models are required prior to their clinical application. the common marmoset (cm) was recently found to be a useful nonhuman primate animal model for drug development and safety assessment. however, a method for the efficient hematopoietic di ... | 2015 | 26073521 |
| natural and anthropogenic hybridization in two species of eastern brazilian marmosets (callithrix jacchus and c. penicillata). | animal hybridization is well documented, but evolutionary outcomes and conservation priorities often differ for natural and anthropogenic hybrids. among primates, an order with many endangered species, the two contexts can be hard to disentangle from one another, which carries important conservation implications. callithrix marmosets give us a unique glimpse of genetic hybridization effects under distinct natural and human-induced contexts. here, we use a 44 autosomal microsatellite marker panel ... | 2015 | 26061111 |
| filamentous fungi isolated from the fur microbiota of callitrichids kept in captivity in brazil. | this study aimed to isolate filamentous fungi from the fur of primates of the genus callithrix kept in the centre for rehabilitation of wild animals (crwa) at the tietê ecological park, são paulo, sp, brazil. samples of the fur of 19 specimens of black-tufted marmosets (callithrix penicillata) and 6 specimens of white-tufted-ear marmosets (callithrix jacchus) were obtained by the square carpet technique. the samples were plated on mycosel™ agar medium (difco™) and incubated at 25°c for 21 days. ... | 2015 | 26056892 |
| comparative analysis of meissner's corpuscles in the fingertips of primates. | meissner's corpuscles (mcs) are tactile mechanoreceptors found in the glabrous skin of primates, including fingertips. these receptors are characterized by sensitivity to light touch, and therefore might be associated with the evolution of manipulative abilities of the hands in primates. we examined mcs in different primate species, including common marmoset (callithrix jacchus, n = 5), baboon (papio anubis, n = 2), rhesus macaque (macaca mulatta, n = 3), chimpanzee (pan troglodytes, n = 3), bon ... | 2015 | 26053332 |
| parturition signaling by visual cues in female marmosets (callithrix jacchus). | new world monkeys have polymorphic color vision, in which all males and some females are dichromats, while most females are trichromats. there is little consensus about which selective pressures fashioned primate color vision, although detection of food, mates and predators has been hypothesized. behavioral evidence shows that males from different species of neotropical primates seem to perceive the timing of female conception and gestation, although, no signals fulfilling this function have bee ... | 2015 | 26047350 |
| advantages and risks of husbandry and housing changes to improve animal wellbeing in a breeding colony of common marmosets (callithrix jacchus). | between 1975 and 2014, housing conditions for laboratory-housed marmosets changed dramatically after the introduction of new guidelines designed to improve their care and wellbeing. according to these guidelines, our facility provided marmosets with outside enclosures, switched to deep litter as bedding material, and discontinued the use of disinfectant agents in animal enclosures. however, both deep litter and access to outside enclosures hypothetically increase the risk of potential exposure t ... | 2015 | 26045452 |
| magnetic resonance imaging of the common marmoset head. | 2015 | 26042350 | |
| behavioral and neurophysiological effects of ro 10-5824, a dopamine d4 receptor partial agonist, in common marmosets. | growing evidence suggests that dopamine d4 receptors (d4rs) are involved in controlling executive functions. we have previously demonstrated that ro 10-5824, a d4r partial agonist, improves the performance of common marmosets in the object retrieval detour (ord) task. however, the neural mechanisms underlying this improvement are unknown. | 2015 | 26041337 |
| allogeneic neural stem/progenitor cells derived from embryonic stem cells promote functional recovery after transplantation into injured spinal cord of nonhuman primates. | : previous studies have demonstrated that neural stem/progenitor cells (ns/pcs) promote functional recovery in rodent animal models of spinal cord injury (sci). because distinct differences exist in the neuroanatomy and immunological responses between rodents and primates, it is critical to determine the effectiveness and safety of allografted embryonic stem cell (esc)-derived ns/pcs (esc-ns/pcs) in a nonhuman primate sci model. in the present study, common marmoset esc-ns/pcs were grafted into ... | 2015 | 26019226 |
| voxel-based morphometry of the marmoset brain: in vivo detection of volume loss in the substantia nigra of the mptp-treated parkinson's disease model. | movement dysfunction in parkinson's disease (pd) is caused by the degeneration of dopaminergic (da) neurons in the substantia nigra (sn). here, we established a method for voxel-based morphometry (vbm) and automatic tissue segmentation of the marmoset monkey brain using a 7-t animal scanner and applied the method to assess da degeneration in a pd model, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated animals, with tyrosine-hydroxylase staining. the most significant decreases of local ... | 2015 | 26012491 |
| the primate autoimmune encephalomyelitis model; a bridge between mouse and man. | multiple sclerosis (ms) is an enigmatic autoimmune-driven inflammatory/demyelinating disease of the human central nervous system (cns), affecting brain, spinal cord, and optic nerves. the cause of the disease is not known and the number of effective treatments is limited. despite some clear successes, translation of immunological discoveries in the mouse experimental autoimmune encephalomyelitis (eae) model into effective therapies for ms patients has been difficult. this translation gap between ... | 2015 | 26000330 |
| muscle contractile properties as an explanation of the higher mean power output in marmosets than humans during jumping. | the muscle mass-specific mean power output (pmms,mean) during push-off in jumping in marmosets (callithrix jacchus) is more than twice that in humans. in the present study it was tested whether this is attributable to differences in muscle contractile properties. in biopsies of marmoset m. vastus lateralis (vl) and m. gastrocnemius medialis (gm) (n=4), fibre-type distribution was assessed using fluorescent immunohistochemistry. in single fibres from four marmoset and nine human vl biopsies, the ... | 2015 | 25987730 |
| multipotent stromal cells derived from common marmoset callithrix jacchus within alginate 3d environment: effect of cryopreservation procedures. | multipotent stromal cells derived from the common marmoset monkey callithrix jacchus (cjmscs) possess high phylogenetic similarity to humans, with a great potential for preclinical studies in the field of regenerative medicine. safe and effective long-term storage of cells is of great significance to clinical and research applications. encapsulation of such cell types within alginate beads that can mimic an extra-cellular matrix and provide a supportive environment for cells during cryopreservat ... | 2015 | 25980899 |
| common marmoset cd117+ hematopoietic cells possess multipotency. | analysis of the hematopoiesis of non-human primates is important to clarify the evolution of primate-specific hematopoiesis and immune regulation. however, the engraftment and development of the primate hematopoietic system are well-documented only in humans and are not clear in non-human primates. callithrix jacchus (common marmoset, cm) is a new world monkey with a high rate of pregnancy and small size that lives in closed colonies. as stem cell factor (scf) is an essential molecule for hemato ... | 2015 | 25977306 |
| higher-order repeat structure in alpha satellite dna occurs in new world monkeys and is not confined to hominoids. | centromeres usually contain large amounts of tandem repeat dna. alpha satellite dna (as) is the most abundant tandem repeat dna found in the centromeres of simian primates. the as of humans contains sequences organized into higher-order repeat (hor) structures, which are tandem arrays of larger repeat units consisting of multiple basic repeat units. hor-carrying as also occurs in other hominoids, but results reported to date for phylogenetically more remote taxa have been negative. here we show ... | 2015 | 25974220 |
| pandemic swine-origin h1n1 influenza virus replicates to higher levels and induces more fever and acute inflammatory cytokines in cynomolgus versus rhesus monkeys and can replicate in common marmosets. | the close immunological and physiological resemblance with humans makes non-human primates a valuable model for studying influenza virus pathogenesis and immunity and vaccine efficacy against infection. although both cynomolgus and rhesus macaques are frequently used in influenza virus research, a direct comparison of susceptibility to infection and disease has not yet been performed. in the current study a head-to-head comparison was made between these species, by using a recently described swi ... | 2015 | 25946071 |
| a sterilizing tuberculosis treatment regimen is associated with faster clearance of bacteria in cavitary lesions in marmosets. | shortening the lengthy treatment duration for tuberculosis patients is a major goal of current drug development efforts. the common marmoset develops human-like disease pathology and offers an attractive model to better understand the basis for relapse and test regimens for effective shorter duration therapy. we treated mycobacterium tuberculosis-infected marmosets with two drug regimens known to differ in their relapse rates in human clinical trials: the standard four-drug combination of isonia ... | 2015 | 25941223 |
| preclinical study of novel gene silencer pyrrole-imidazole polyamide targeting human tgf-β1 promoter for hypertrophic scars in a common marmoset primate model. | we report a preclinical study of a pyrrole-imidazole (pi) polyamide that targets the human transforming growth factor (htgf)-β1 gene as a novel transcriptional gene silencer in a common marmoset primate model. we designed and then synthesized pi polyamides to target the htgf-β1 promoter. we examined effects of seven pi polyamides (gb1101-1107) on the expression of htgf-β1 mrna stimulated with phorbol 12-myristate 13-acetate (pma) in human vascular smooth muscle cells. gb1101, gb1105 and gb1106 s ... | 2015 | 25938472 |
| characterization of long-term motor deficits in the 6-ohda model of parkinson's disease in the common marmoset. | research aimed at developing new therapies for parkinson's disease (pd) critically depend on valid animal models of the disease that allows for repeated testing of motor disabilities over extended time periods. we here present an extensive characterization of a wide range of motor symptoms in the 6-ohda marmoset model of pd when tested over several months. the severity of motor deficits was quantified in two ways: (i) through manual scoring protocols appropriately adapted to include species spec ... | 2015 | 25934488 |
| molecular characterization, polymorphism, and association of porcine gadd45g gene. | growth arrest and dna-damage-inducible gamma (gadd45g) is a reproduction related gene. in this study, the full-length cdna sequence of porcine gadd45g gene was cloned through rapid amplification of cdna ends (race) method. the porcine gadd45g gene encodes a protein of 159 amino acids that shares high homology with the gadd45g of nine species: chimpanzee (97%), sumatran orangutan (97%), white-tufted-ear marmoset (97%), northern white-cheeked gibbon (97%), cattle (97%), human (97%), rhesus monkey ... | 2015 | 25927170 |
| vocal turn-taking in a non-human primate is learned during ontogeny. | conversational turn-taking is an integral part of language development, as it reflects a confluence of social factors that mitigate communication. humans coordinate the timing of speech based on the behaviour of another speaker, a behaviour that is learned during infancy. while adults in several primate species engage in vocal turn-taking, the degree to which similar learning processes underlie its development in these non-human species or are unique to language is not clear. we recorded the nat ... | 2015 | 25904663 |
| opposite effects of male and female helpers on social tolerance and proactive prosociality in callitrichid family groups. | across a broad variety of primate species (including lemurs, new world monkeys, old world monkeys, and apes), proactive prosociality and social tolerance are linked to allomaternal care, reaching the highest levels in the cooperatively breeding callitrichid monkeys and humans. however, considerable variation exists within callitrichids, and the aim of this study was to identify factors that explain this variation. male and female callitrichids pursue different reproductive strategies, leading ma ... | 2015 | 25881136 |
| the role of inhibition in a computational model of an auditory cortical neuron during the encoding of temporal information. | in auditory cortex, temporal information within a sound is represented by two complementary neural codes: a temporal representation based on stimulus-locked firing and a rate representation, where discharge rate co-varies with the timing between acoustic events but lacks a stimulus-synchronized response. using a computational neuronal model, we find that stimulus-locked responses are generated when sound-evoked excitation is combined with strong, delayed inhibition. in contrast to this, a non-sy ... | 2015 | 25879843 |
| motion dependence of smooth pursuit eye movements in the marmoset. | smooth pursuit eye movements stabilize slow-moving objects on the retina by matching eye velocity with target velocity. two critical components are required to generate smooth pursuit: first, because it is a voluntary eye movement, the subject must select a target to pursue to engage the tracking system; and second, generating smooth pursuit requires a moving stimulus. we examined whether this behavior also exists in the common marmoset, a new world primate that is increasingly attracting attent ... | 2015 | 25867740 |
| use of the common marmoset to study burkholderia mallei infection. | burkholderia mallei is a host-adapted bacterium that does not persist outside of its equine reservoir. the organism causes the zoonosis glanders, which is endemic in asia, africa, the middle east and south america. infection by b. mallei typically occurs via the respiratory or percutaneous route, and the most common manifestations are life-threatening pneumonia and bacteremia. glanders is difficult to diagnose and requires prolonged antibiotic therapy with low success rates. there is no vaccine ... | 2015 | 25860021 |
| substrate selectivities and catalytic activities of marmoset liver cytochrome p450 2a6 differed from those of human p450 2a6. | the common marmoset (callithrix jacchus), a new world primate species, is potentially a useful animal model for preclinical studies in drug development. however, cytochrome p450 (p450) enzymes have not been fully identified and characterized in marmosets. in this study, we identified p450 2a6 cdna with the sequence highly identical (91-94%) to human p450 2a6, 2a7, and 2a13 cdna and cynomolgus monkey p450 2a23, 2a24, and 2a26 cdna. among the tissue types examined, marmoset p450 2a6 mrna was most ... | 2015 | 25858611 |
| measurement of 25-hydroxyvitamin d(2&3) and 1,25-dihydroxyvitamin d(2&3) by tandem mass spectrometry: a primate multispecies comparison. | vitamin d metabolites are widely studied for their roles in bone health, immune functions, and other potential physiologic roles in humans. however, the optimal blood levels of vitamin d metabolites are still unclear. various methods for measuring vitamin d metabolites have been used and recently liquid chromatography tandem mass spectroscopy (lc-ms/ms) has been adopted as the gold standard for vitamin d metabolite measurement. here, we report the use of lc-ms/ms to measure 25-hydroxyvitamin d ( ... | 2015 | 25845705 |
| body weight-associated differences in ovarian morphology in captive common marmoset (callithrix jacchus). | in captivity, callithrix jacchus (common marmoset) is on average heavier than their wild-living counterparts, and has a tendency to produce triplet litters rather than the normal twins. to provide initial basic information about possible weight-related differences among the ovaries, a morphometric study of follicular phase ovaries from 48 young adult marmosets has been carried out. nearly 90% of these ovaries were found to contain some degree of luteal tissue composed of large and/or small cells ... | 2015 | 25842250 |
| take the monkey and run. | the common marmoset (callithrix jacchus) is a small, new world primate that is used extensively in biomedical and behavioral research. this short-lived primate, with its small body size, ease of handling, and docile temperament, has emerged as a valuable model for aging and neurodegenerative research. a growing body of research has indicated exercise, aerobic exercise especially, imparts beneficial effects to normal aging. understanding the mechanisms underlying these positive effects of exercis ... | 2015 | 25835199 |
| brain/minds: brain-mapping project in japan. | there is an emerging interest in brain-mapping projects in countries across the world, including the usa, europe, australia and china. in 2014, japan started a brain-mapping project called brain mapping by integrated neurotechnologies for disease studies (brain/minds). brain/minds aims to map the structure and function of neuronal circuits to ultimately understand the vast complexity of the human brain, and takes advantage of a unique non-human primate animal model, the common marmoset (callithr ... | 2015 | 25823872 |
| current models of the marmoset brain. | since the availability of the common marmoset monkey as a primate model in neuroscience research has recently increased, much effort has been made to develop a reliable guide of the brain structures of this species. in this article, we review the development of the marmoset brain atlas and discuss a newly developed brain model, which was reconstructed from histological sections under volume-rendering technology. this kind of brain model allows virtual sections to be constructed on any axis, with ... | 2015 | 25817023 |
| cognitive bias, hand preference and welfare of common marmosets. | common marmosets (callithrix jacchus) have hand preferences for grasping pieces of food and holding them while eating and these are stable throughout adult life. we report here that left-handed marmosets have negative cognitive bias compared to right-handed marmosets. twelve marmosets were trained to expect a food reward from a bowl with a black lid and not from one with a white lid, or vice versa. in probe tests with ambiguous, grey-lidded bowls a left-handed group (n=7) were less likely to rem ... | 2015 | 25813746 |
| developmental expression patterns of chemokines cxcl11, cxcl12 and their receptor cxcr7 in testes of common marmoset and human. | the chemokine receptor cxcr7 interacts with the chemokines cxcl11 and cxcl12. during development, this ligand receptor system (c-x-c) provokes cell-type-specific responses in terms of migration, adhesion or ligand sequestration. it is active in zebrafish and rodents but no data are available for its presence or function in primate testes. real-time quantitative polymerase chain reaction was performed in monkeys to detect cxcl11, cxcl12 and cxcr7. at the protein level, cxcl12 and cxcr7 were local ... | 2015 | 25810367 |
| proteomic analysis of cerebellum in common marmoset exposed to methylmercury. | the cerebellum is known as the major target regions of methylmercury (mehg) toxicity, but the mechanisms are still not fully understood. we studied the effects of mehg exposure in the cerebellum of common marmoset (callithrix jacchus) using a shotgun proteomic approach with liquid chromatography coupled to mass spectrometry. a total of 1000 common proteins were identified in all samples, and 102 proteins were significantly differentially expressed in the cerebellum of common marmoset with orally ... | 2015 | 25809596 |
| noninvasive genotyping of common marmoset (callithrix jacchus) by fingernail pcr. | the common marmoset (callithrix jacchus) is a new world primate that is a useful model for medical studies. in this study, we report a convenient, reliable, and noninvasive procedure to genotype a living common marmoset by using fingernails. this method was used to successfully genotype dna by restriction fragment length polymorphism (rflp) pcr without prior purification, by using the kod fx pcr enzyme kit. additionally, there is no sample contamination from hematopoietic chimera derived from fu ... | 2015 | 25805040 |
| expression of bioactive callithrix jacchus follicle-stimulating hormone in pichia pastoris. | callithrix jacchus (common marmoset) is a new world primate monkey, used as an animal model in biomedical research. marmoset-specific follicle-stimulating hormone (fsh) preparation is required to improve superovulation protocols and to develop homologous fsh monitoring assays in these monkeys. in this study, we document the large-scale expression of recombinant marmoset fsh in methylotropic yeast, pichia pastoris. the recombinant preparation was found to be immunologically active in western blot ... | 2015 | 25805018 |
| the serotonin 5-ht₁a receptor agonist tandospirone improves executive function in common marmosets. | previous pilot clinical studies have shown that the serotonin 5-ht1a receptor agonist tandospirone has beneficial effect on cognitive deficits associated with schizophrenia. in the present study, we evaluated the cognitive efficacy of tandospirone, given alone or in combination with the antipsychotic blonanserin, risperidone or haloperidol, on executive function in marmosets using the object retrieval with detour (ord) task. treatment with tandospirone alone at 20 and 40 mg/kg increased the numb ... | 2015 | 25804359 |
| marmoset cytochrome p450 2d8 in livers and small intestines metabolizes typical human p450 2d6 substrates, metoprolol, bufuralol and dextromethorphan. | 1. although the new world non-human primate, the common marmoset (callithrix jacchus), is a potentially useful animal model, comprehensive understanding of drug metabolizing enzymes is insufficient. 2. a cdna encoding a novel cytochrome p450 (p450) 2d8 was identified in marmosets. the amino acid sequence deduced from p450 2d8 cdna showed a high sequence identity (83-86%) with other primate p450 2ds. phylogenetic analysis showed that marmoset p450 2d8 was closely clustered with human p450 2d6, un ... | 2015 | 25801057 |
| non-viral generation of marmoset monkey ips cells by a six-factor-in-one-vector approach. | groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins. the resulting pluripotent cells, called induced pluripotent stem (ips) cells, could be an alternative to embryonic stem cells, which are under continuous ethical debate. hence, ips cell-derived functional cells such as neurons may become the key for an effective treatment of currently incurable degenerative dise ... | 2015 | 25785453 |
| an experimental model for exudative age-related macular degeneration with choroidal neovascularization using the common marmoset. | this study aimed to establish an experimental exudative age-related macular degeneration (amd) model in the common marmoset (callithrix jacchus), which is a small new world monkey. choroidal neovascularization (cnv) was induced by laser irradiation on the left eye of each animal under anesthesia. eight laser spots were applied around the macular area using the image-guided laser system (532 nm) attached with micron iii at 650 mw-2,000 mw power. laser pulse duration and spot size were fixed at 10 ... | 2015 | 25760220 |