Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| the muc1 mucin specifically inhibits activation of the nlrp3 inflammasome. | muc1 is a cell membrane-associated mucin, expressed ubiquitously on the mucosal epithelia as well as by immune cells, that limits the inflammatory response to multiple pathogens. we have recently shown that muc1 controls inflammation resulting from helicobacter pylori infection by suppressing interleukin-1β (il-1β) produced via the nlrp3 inflammasome. here, we demonstrate that muc1 also regulates il-1β secretion induced by the nlrp3-activating bacteria haemophilus influenzae but not bacteria tha ... | 2016 | 26938663 |
| immunization coverage surveys and linked biomarker serosurveys in three regions in ethiopia. | demographic and health surveys, immunization coverage surveys and administrative data often divergently estimate vaccination coverage, which hinders pinpointing districts where immunization services require strengthening. we assayed vaccination coverage in three regions in ethiopia by coverage surveys and linked serosurveys. | 2016 | 26934372 |
| bacterial colonization and associated factors in patients with bronchiectasis. | to evaluate the bacterial colonization and associated risk factors in patients with bronchiectasis. | 2017 | 26933458 |
| comparison of the immunogenicity and safety of pentavalent vaccine quinvaxem in a compact prefilled auto-disabled (cpad) injection system versus single-dose vials in healthy infants: a phase 3, open-label, randomized, parallel-group, non-inferiority study. | to evaluate non-inferiority of three doses of quinvaxem in a compact prefilled auto-disabled (cpad) injection system versus quinvaxem in a single-dose vial administered with conventional syringe in terms of seroconversion/seroprotection rates for all antibodies (anti-hepatitis b (hb), anti-haemophilus influenzae type b polyribosylribitol phosphate (hib prp), anti-diphtheria, anti-tetanus, anti-bordetella pertussis) at 1 month after primary vaccination. | 2016 | 26923083 |
| [vaccination for international travelers]. | traveler's vaccination is one of the key strategies for the prevention of infectious diseases during international travel. the risk of acquiring an infectious disease is determined in each case by the characteristics of the traveler and the travel, so the pre-departure medical advice of the traveler must be individualized. the world health organization classifies travelerś vaccines into three groups. - vaccines for routine use in national immunization programs: haemophilus influenzae type b, hep ... | 2016 | 26920587 |
| sex-dependent immune responses to infant vaccination: an individual participant data meta-analysis of antibody and memory b cells. | biological sex can be an important source of variation in infection and immunity and sex-dependent differences in immune response to vaccination have been reported in some studies. | 2016 | 26920472 |
| prevalence, codetection and seasonal distribution of upper airway viruses and bacteria in children with acute respiratory illnesses with cough as a symptom. | most studies exploring the role of upper airway viruses and bacteria in paediatric acute respiratory infections (ari) focus on specific clinical diagnoses and/or do not account for virus-bacteria interactions. we aimed to describe the frequency and predictors of virus and bacteria codetection in children with ari and cough, irrespective of clinical diagnosis. bilateral nasal swabs, demographic, clinical and risk factor data were collected at enrollment in children aged <15 years presenting to an ... | 2016 | 26916343 |
| a glycoconjugate of haemophilus influenzae type b capsular polysaccharide with tetanus toxoid protein: hydrodynamic properties mainly influenced by the carbohydrate. | three important physical properties which may affect the performance of glycoconjugate vaccines against serious disease are molar mass (molecular weight), heterogeneity (polydispersity), and conformational flexibility in solution. the dilute solution behaviour of native and activated capsular polyribosylribitol (prp) polysaccharides extracted from haemophilus influenzae type b (hib), and the corresponding glycoconjugate made by conjugating this with the tetanus toxoid (tt) protein have been char ... | 2016 | 26915577 |
| susceptibility to lower respiratory infections in childhood is associated with perturbation of the cytokine response to pathogenic airway bacteria. | neonatal colonization of the airways with respiratory pathogens is associated with increased risk of lower respiratory infections (lri) in early childhood. therefore, we hypothesized that children developing lri have an aberrant immune response to pathogenic bacteria in infancy. the objective was to characterize in vitro the early life systemic immune response to pathogenic bacteria and study the possible association with incidence of lri during the first 3 years of life. | 2016 | 26910587 |
| maternal helminth infection is associated with higher infant immunoglobulin a titers to antigen in orally administered vaccines. | many studies have documented lower vaccine efficacy among children in low-income countries, compared with their counterparts in high-income countries. this disparity is especially apparent with respect to oral vaccines such as rotavirus and oral polio vaccines. one potential contributing factor is the presence of maternal antenatal helminth infections, which can modulate the infant's developing immune system. | 2016 | 26908751 |
| hib vaccines: past, present, and future perspectives. | haemophilus influenzae type b (hib) causes many severe diseases, including epiglottitis, pneumonia, sepsis, and meningitis. in developed countries, the annual incidence of meningitis caused by bacteria is approximately 5-10 cases per population of 100,000. the hib conjugate vaccine is considered protective and safe. adjuvants, molecules that can enhance and/or regulate the fundamental immunogenicity of an antigen, comprise a wide range of diverse compounds. while earlier developments of adjuvant ... | 2016 | 26904695 |
| developing a vaccine to prevent otitis media caused by nontypeable haemophilus influenzae. | nontypeable haemophilus influenzae (nthi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. protein-based vaccines to prevent nthi infections are needed to alleviate these infections in children and vulnerable populations such as the elderly and those with chronic obstructive pulmonary disease (copd). one nthi protein is included in a pneumococcal conjugate vaccine ... | 2016 | 26894630 |
| immunization coverage among splenectomized patients: results of an ad hoc survey in puglia region (south of italy). | patients with anatomic or functional asplenia have a 10-50 times higher risk than general population to develop overwhelming post-splenectomy infection. evidences are unanimous in recommending splenectomised patients to receive meningococcal, antipneumococcal and haemophilus influenzae type b vaccinations according to a specific timing. in italy there are no current data on the immunisation coverage in these patients. this study aims to investigate immunisation coverage in patients undergoing el ... | 2016 | 26890256 |
| oral polio vaccination and hospital admissions with non-polio infections in denmark: nationwide retrospective cohort study. | background. live vaccines may have nonspecific beneficial effects on morbidity and mortality. this study examines whether children who had the live-attenuated oral polio vaccine (opv) as the most recent vaccine had a different rate of admissions for infectious diseases than children with inactivated diphtheria-tetanus-pertussis-polio-haemophilus influenzae type b vaccine (dtap-ipv-hib) or live measles-mumps-rubella vaccine (mmr) as their most recent vaccine. methods. a nationwide, register-bas ... | 2016 | 26885538 |
| conjugate haemophilus influenzae type b vaccines for sickle cell disease. | people affected with sickle cell disease are at high risk of infection from haemophilus influenzae type b. before the implementation of haemophilus influenzae type b conjugate vaccination in high-income countries, this was responsible for a high mortality rate in children under five years of age. in african countries, where coverage of this vaccination is still extremely low, haemophilus influenzae type b remains one of the most common cause of bacteraemias in children with sickle cell disease. ... | 2016 | 26881484 |
| [multicenter prospective epidemiological studies on haemophilus influenzae infection among hospitalized children with lower respiratory tract infections]. | to understand epidemiological characteristics of haemophilus influenzae (hi) infection in hospitalized children with lower respiratory tract infection (lrti) in west sichuan china. | 2016 | 26875462 |
| lobar distribution in non-cystic fibrosis bronchiectasis predicts bacteriologic pathogen treatment. | non-cystic fibrosis bronchiectasis (ncfbr) is a major cause of morbidity due to frequent infectious exacerbations. we analyzed the influence of patient age and bronchiectasis location on the bacterial profile of patients with ncfbr. this retrospective cohort study included 339 subjects diagnosed with an infectious exacerbation of ncfbr during the 9-year period between january 2006 and december 2014. bronchoalveolar lavage (bal) cultures and high-resolution computed tomography scans (hrct) were u ... | 2016 | 26873379 |
| bacteremia in children hospitalized with respiratory syncytial virus infection. | the risk of bacteremia is considered low in children with acute bronchiolitis. however the rate of occult bacteremia in infants with rsv infection is not well established. the aim was to determine the actual rate and predictive factors of bacteremia in children admitted to hospital due to confirmed rsv acute respiratory illness (ari), using both conventional culture and molecular techniques. | 2016 | 26872131 |
| environmental enteropathy, oral vaccine failure and growth faltering in infants in bangladesh. | environmental enteropathy (ee) is a subclinical enteric condition found in low-income countries that is characterized by intestinal inflammation, reduced intestinal absorption, and gut barrier dysfunction. we aimed to assess if ee impairs the success of oral polio and rotavirus vaccines in infants in bangladesh. | 2015 | 26870801 |
| is alveolar macrophage phagocytic dysfunction in children with protracted bacterial bronchitis a forerunner to bronchiectasis? | children with recurrent protracted bacterial bronchitis (pbb) and bronchiectasis share common features, and pbb is likely a forerunner to bronchiectasis. both diseases are associated with neutrophilic inflammation and frequent isolation of potentially pathogenic microorganisms, including nontypeable haemophilus influenzae (nthi), from the lower airway. defective alveolar macrophage phagocytosis of apoptotic bronchial epithelial cells (efferocytosis), as found in other chronic lung diseases, may ... | 2016 | 26867834 |
| immunogenicity and safety of quinvaxem® (diphtheria, tetanus, whole-cell pertussis, hepatitis b and haemophilus influenzae type b vaccine) given to vietnamese infants at 2 to 4 months of age. | vietnam plans to replace the routine childhood diphtheria, pertussis and tetanus combination (dpt) vaccine with a pentavalent vaccine. the present study was performed to assess the immunogenicity and safety of the combined diphtheria, tetanus, whole-cell pertussis, hepatitis b (hepb), and haemophilus influenzae type b (hib) (dtwp-hepb-hib) quinvaxem® vaccine in children. a total of 131 infants received the quinvaxem® vaccine at 2, 3 and 4 months. antibody levels were measured at baseline, at one ... | 2015 | 26867396 |
| safety of a crm197-conjugated haemophilus influenzae type b vaccine in korean children. | haemophilus influenzae type b (hib) is a major cause of meningitis and pneumonia with high morbidity and mortality rates in young children. the introduction of effective and well-tolerated conjugate hib vaccines, has nearly eradicated this disease in many countries. we investigated the safety of the hib prp-crm197 vaccine in a multi-center post-marketing surveillance (pms) study. korean children (n = 764) aged 1-33 months were enrolled when receiving a routine primary immunization or a booster v ... | 2015 | 26867395 |
| clinical characteristics of the patients with bacteremia due to moraxella catarrhalis in children: a case-control study. | invasive diseases due to moraxella catarrhalis are rare in children, even in immunocompromised hosts. therefore, data regarding clinical characteristics and risk factors of such patients are limited. the aim of this study is to compare the clinical characteristics of patients with bacteremia due to moraxella catarrhalis against those with bacteremia due to streptococcus pneumoniae and haemophilus influenzae. | 2015 | 26861621 |
| synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. | a new azithromycin-based series of antibacterial macrolones is reported, which features the use of a 4″-ester linked glycin for tethering the quinolone side chain to the macrolide scaffold. among the analogs prepared, compounds 9e and 22f with a quinolon-6-yl moiety were found to have potent and well-balanced activity against clinically important respiratory tract pathogens, including erythromycin-susceptible and mlsb resistant strains of streptococcus pneumoniae, streptococcus pyogenes, and hae ... | 2016 | 26860929 |
| supersilac quantitative proteome profiling of murine middle ear epithelial cell remodeling with nthi. | chronic otitis media with effusion (come) develops after sustained inflammation and is characterized by secretory middle ear epithelial metaplasia and effusion, most frequently mucoid. non-typeable haemophilus influenzae (nthi), the most common acute otitis media (om) pathogen, is postulated to promote middle ear epithelial remodeling in the progression of om from acute to chronic. the goals of this study were to examine histopathological and quantitative proteomic epithelial effects of nthi cha ... | 2016 | 26859300 |
| intercellular adhesion molecule 1 serves as a primary cognate receptor for the type iv pilus of nontypeable haemophilus influenzae. | nontypeable haemophilus influenzae (nthi) utilizes the type iv pilus (tfp) to adhere to respiratory tract epithelial cells thus colonizing its human host; however, the host cell receptor to which this adhesive protein binds is unknown. from a panel of receptors engaged by tfp expressed by other bacterial species, we showed that the majority subunit of nthi tfp, pila, bound to intercellular adhesion molecule 1 (icam1) and that this interaction was both specific and of high affinity. further, tfp- ... | 2016 | 26857242 |
| microbial colonization and lung function in adolescents with cystic fibrosis. | with intensified antibiotic therapy and longer survival, patients with cystic fibrosis (cf) are colonized with a more complex pattern of bacteria and fungi. however, the clinical relevance of these emerging pathogens for lung function remains poorly defined. the aim of this study was to assess the association of bacterial and fungal colonization patterns with lung function in adolescent patients with cf. microbial colonization patterns and lung function parameters were assessed in 770 adolescent ... | 2016 | 26856310 |
| the impact of exogenous factors on respiratory pathogen-induced innate alveolar macrophage responses in copd. | alveolar macrophages in chronic obstructive pulmonary disease (copd) have fundamentally impaired innate immune responses to toll-like receptor (tlr) ligands of nontypeable haemophilus influenzae (nthi). however, whether dysfunctional inflammatory responses in copd extend to macrophage interactions with intact respiratory pathogens beyond nthi has not been explored. furthermore, the influences of exogenous factors, including active smoking and medications, on pathogen-induced innate immune respon ... | 2016 | 26853802 |
| rationale and prospects of targeting bacterial two-component systems for antibacterial treatment of cystic fibrosis patients. | bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (cf) patients. in early childhood, the respiratory infections are due to staphylococcus aureus and haemophilus influenzae. in older cf patients, pathogenic gram-negative bacteria like achromobacter xylosoxidans, burkholderia cepacia complex and especially pseudomonas aeruginosa are more frequently seen. p. aeruginosa is a turning point in the respiratory disease in cf and its predominance increa ... | 2016 | 26853320 |
| effect of haemophilus influenzae type b vaccination without a booster dose on invasive h influenzae type b disease, nasopharyngeal carriage, and population immunity in kilifi, kenya: a 15-year regional surveillance study. | haemophilus influenzae type b (hib) conjugate vaccine, delivered as a three-dose series without a booster, was introduced into the childhood vaccination programme in kenya in 2001. the duration of protection and need for a booster dose are unknown. we aimed to assess vaccine effectiveness, the impact of the vaccine on nasopharyngeal carriage, and population immunity after introduction of conjugate hib vaccine in infancy without a booster dose in kenya. | 2016 | 26853149 |
| the role of solithromycin in the management of bacterial community-acquired pneumonia. | the fluoroketolide solithromycin is 2-fold more potent in vitro than telithromycin against pneumococci (including macrolide-resistant strains) and haemophilus influenzae and very active on pathogens causing atypical pneumonia. in contrast, it is a 30-fold less potent inhibitor of nicotinic receptors incriminated in telithromycin toxicity. in phase ii/iii trials, oral solithromycin once-daily (800 mg on day 1; 400 mg on days 2-5) proved effective and safe when compared to respiratory fluoroquinol ... | 2016 | 26848612 |
| streptococcus pneumoniae and haemophilus species colonization in health care workers: the launch of invasive infections? | streptococcus pneumoniae and haemophilus influenzae are important human pathogens. the risk of airborne and droplet-transmitted respiratory tract infections in healthcare workers (hcw) is substantial. the aim of this study was to determine the extent of oropharyngeal colonization with s. pneumoniae and haemophilus spp. their antibiogram and risk factors of colonization in hcw at a tertiary care center, western nepal. | 2016 | 26847639 |
| male non-gonococcal urethritis: from microbiological etiologies to demographic and clinical features. | to detect microorganisms responsible for male acute urethritis and to define the microbiology of non-gonococcal urethritis. | 2016 | 26845624 |
| invasive haemophilus influenzae serotype f case reports in mazovia province, poland. | after successful introduction of anti-haemophilus influenzae (hi) serotype b vaccination program in poland, invasive non-b or nontypeable h. influenzae infections have been reported more frequently alike in other countries all over the world. in this paper, we report 2 cases of h. influenzae serotype f (hif) meningitis with severe clinical presentations which are rarely seen in previously healthy children.the first case is a 6-year-old girl who was admitted to pediatric ward with signs of mening ... | 2016 | 26844500 |
| resolvin d1 dampens pulmonary inflammation and promotes clearance of nontypeable haemophilus influenzae. | nontypeable haemophilus influenzae (nthi) is a gram-negative, opportunistic pathogen that frequently causes ear infections, bronchitis, pneumonia, and exacerbations in patients with underlying inflammatory diseases, such as chronic obstructive pulmonary disease. in mice, nthi is rapidly cleared, but a strong inflammatory response persists, underscoring the concept that nthi induces dysregulation of normal inflammatory responses and causes a failure to resolve. lipid-derived specialized proresolv ... | 2016 | 26843331 |
| non-typeable haemophilus influenzae purulent pericarditis in a child with cystic fibrosis. | early airway colonization and infection with haemophilus influenzae in children with cystic fibrosis (cf) is common. although the pathogenicity of non-typeable h. influenzae (nthi) in patients with cf is controversial, this organism can cause both upper and lower respiratory tract infections. extra-pulmonary disease, however, is rare. purulent pericarditis is a suppurative complication of bacterial infection of the pericardial space that can arise as a result of direct extension from an adjacent ... | 2016 | 26842501 |
| factors associated with parental refusal of routine vaccination in the czech republic. | routine vaccination is one of the most important preventive methods which is responsible for the decreasing trend of morbidity and mortality of vaccine preventable infectious diseases, their complications and sequelae. the impact of vaccination on declining trend of these diseases is well known and confirmed by a large number of epidemiological studies. in the czech republic, there is high vaccination coverage in regards to most vaccine preventable diseases. however, during the last decade propo ... | 2015 | 26841145 |
| diagnosis of upper and lower respiratory tract bacterial infections with the use of multiplex pcr assays. | the investigation of respiratory infections by molecular techniques provides important information about the epidemiology of respiratory disease, especially during the post-vaccination era. the objective of the present study was the detection of bacterial pathogens directly in clinical samples from patients with upper and lower respiratory tract infections using multiplex polymerase chain reaction (pcr) assays developed in our laboratory. clinical samples taken over a three-year period (2007-200 ... | 2013 | 26835676 |
| a pilot study of quantitative loop-mediated isothermal amplification-guided target therapies for hospital-acquired pneumonia. | it is important to achieve the definitive pathogen identification in hospital-acquired pneumonia (hap), but the traditional culture results always delay the target antibiotic therapy. we assessed the method called quantitative loop-mediated isothermal amplification (qlamp) as a new implement for steering of the antibiotic decision-making in hap. | 2016 | 26830989 |
| development of real-time pcr methods for the detection of bacterial meningitis pathogens without dna extraction. | neisseria meningitidis (nm), haemophilus influenzae (hi), and streptococcus pneumoniae (sp) are the lead causes of bacterial meningitis. detection of these pathogens from clinical specimens using traditional real-time pcr (rt-pcr) requires dna extraction to remove the pcr inhibitors prior to testing, which is time consuming and labor intensive. in this study, five species-specific (nm-sodc and -ctra, hi-hpd#1 and -hpd#3 and sp-lyta) and six serogroup-specific rt-pcr tests (a, b, c, w, x, y) targ ... | 2016 | 26829233 |
| process development of a new haemophilus influenzae type b conjugate vaccine and the use of mathematical modeling to identify process optimization possibilities. | vaccination is one of the most successful public health interventions being a cost-effective tool in preventing deaths among young children. the earliest vaccines were developed following empirical methods, creating vaccines by trial and error. new process development tools, for example mathematical modeling, as well as new regulatory initiatives requiring better understanding of both the product and the process are being applied to well-characterized biopharmaceuticals (for example recombinant ... | 2016 | 26821825 |
| molecular epidemiology of ampicillin-resistant haemophilus influenzae causing acute otitis media in japanese infants and young children. | nontypeable haemophilus influenzae is a particularly important cause of acute otitis media (aom). there is a high prevalence of β-lactamase-nonproducing ampicillin-resistant (blnar) strains in japanese children, which is associated with recurrent aom and prolonged treatment. the aim of this study was to investigate the antimicrobial susceptibility profile, mechanisms of ampicillin resistance and molecular epidemiology of ampicillin resistance in h. influenzae strains causing aom in japanese chil ... | 2016 | 26808724 |
| a novel mechanism for the biogenesis of outer membrane vesicles in gram-negative bacteria. | bacterial outer membrane vesicles (omvs) have important biological roles in pathogenesis and intercellular interactions, but a general mechanism of omv formation is lacking. here we show that the vacj/yrb abc (atp-binding cassette) transport system, a proposed phospholipid transporter, is involved in omv formation. deletion or repression of vacj/yrb increases omv production in two distantly related gram-negative bacteria, haemophilus influenzae and vibrio cholerae. lipidome analyses demonstrate ... | 2016 | 26806181 |
| [real-time pcr detection of neisseria meningitidis, haemophilus influenzae, and streptococcus pneumoniae dna in clinical specimens]. | the study aim was to implement a molecular real-time polymerase chain reaction (pcr) assay recommended by the cdc (centers for disease control and prevention) for the detection of neisseria meningitidis, haemophilus influenzae, and streptococcus pneumoniae in clinical (culture negative) specimens from patients with suspected invasive bacterial disease. clinical specimens are referred to the national reference laboratory (nrl) for meningococcal infections, unit for airborne bacterial infections, ... | 2015 | 26795226 |
| correction: detection of streptococcus pneumoniae and haemophilus influenzae type b by real-time pcr from dried blood spot samples among children with pneumonia: a useful approach for developing countries. | 2016 | 26785260 | |
| otitis media: a review, with a focus on alternative treatments. | otitis media (om) is the accumulation of fluids in the middle ear, with or without symptoms of inflammation. the infection is caused by dysfunction or obstruction of the eustachian tube and is most commonly diagnosed in children under the age of two. the microbiology of om differs, with streptococcus pneumoniae, non-typeable haemophilus influenzae and moraxella catarrhalis the most commonly isolated pathogens. the emergence of penicillin-resistant strep. pneumoniae, β-lactamase-producing strains ... | 2009 | 26783131 |
| copd is characterized by increased detection of haemophilus influenzae, streptococcus pneumoniae and a deficiency of bacillus species. | chronic obstructive pulmonary disease (copd) is characterized by progressive airflow limitation and inflammation. airway bacterial colonization is increased in copd; however, the role of potentially pathogenic and non-pathogenic bacteria in the pathogenesis of disease is unclear. this study characterized the presence of bacteria in a well-characterized cohort of adults with copd and healthy controls. | 2016 | 26781464 |
| [bacterial pathogenic characteristics of respiratory tract infection in children in suzhou, china: an analysis of 14,994 cases]. | to investigate the bacterial pathogenic characteristics of respiratory tract infection in children. | 2016 | 26781412 |
| dna aptamers for the detection of haemophilus influenzae type b by cell selex. | haemophilus influenzae type b (hib) causes acute bacterial meningitis (abm) in children, with a mortality rate of about 3-6 % of the affected patients. abm can lead to death during a period of hours to several days and, hence, rapid and early detection of the infection is crucial. aptamers, the short single-stranded dna or rna with high affinity to target molecules, are selected by a high-flux screening technique known as in vitro screening and systematic evolution of ligands by exponential enri ... | 2016 | 26768582 |
| laboratory characterization of invasive haemophilus influenzae isolates from nunavut, canada, 2000-2012. | with invasive haemophilus influenzae serotype b (hib) disease controlled by vaccination with conjugate hib vaccines, there is concern that invasive disease due to non-serotype b strains may emerge. | 2016 | 26765260 |
| [clinical features of protracted bacterial bronchitis in children]. | to analyze the clinical characteristics of protracted bacterial bronchitis (pbb) in children. | 2015 | 26758117 |
| epidemiological, clinical and prognostic profile of childhood acute bacterial meningitis in a resource poor setting. | childhood bacterial meningitis is a neurologic emergency that continues to kill and maims children particularly in developing countries with poor immunization coverage. | 2015 | 26752902 |
| antibacterial properties of tebipenem pivoxil tablet, a new oral carbapenem preparation against a variety of pathogenic bacteria in vitro and in vivo. | to systemically investigate the in vitro and in vivo antibacterial properties of tebipenem pivoxil tablet. in addition, acute toxicity of this preparation was also studied. | 2016 | 26751436 |
| [middle ear infection]. | middle ear infection is one of the most common childhood infections and the leading reason for antibiotic prescriptions. although the etiological diagnosis is rarely discovered, successful identification of pathogens depends on properly collected sample, chosen method and microbiological analysis made on time. the most common bacterial pathogen is streptococcus pneumoniae. others include haemophilus influenzae, moraxella catarrhalis and pseudomonas aeruginosa, known as the most common bacterial ... | 2016 | 26749955 |
| comprehensive molecular testing for respiratory pathogens in community-acquired pneumonia. | the frequent lack of a microbiological diagnosis in community-acquired pneumonia (cap) impairs pathogen-directed antimicrobial therapy. this study assessed the use of comprehensive multibacterial, multiviral molecular testing, including quantification, in adults hospitalized with cap. | 2016 | 26747825 |
| a proteomic characterization of nthi lysates. | non-typeable haemophilus influenzae (nthi) is a ubiquitous bacterial pathogen which accounts for a majority of human upper respiratory tract infections. laboratory lysate preparations from this bacterium are commonly utilized to investigate the promulgation of inflammatory responses in respiratory and middle ear epithelium both in vivo and in vitro. we undertook an unbiased proteomics based analysis of nthi lysate preps to: (a) identify abundant bacterial proteins present in these lysates that c ... | 2016 | 26746604 |
| invasive disease due to haemophilus influenzae type a in children in canada's north: a priority for prevention. | 2017 | 26744583 | |
| the short-term impact of each primary dose of pneumococcal conjugate vaccine on nasopharyngeal carriage: systematic review and meta-analyses of randomised controlled trials. | early onset of persistent otitis media is a priority issue for australian indigenous populations. the objective is to determine the direct and short-term impact of one, two and three doses of any pneumococcal conjugate vaccine (pcv) formulation on nasopharyngeal (np) carriage of streptococcus pneumoniae (spn) and non-typeable haemophilus influenzae (nthi), the otopathogens targeted by current pcvs. | 2016 | 26742947 |
| [a multicenter study of the antimicrobial susceptibility of streptococcus pneumoniae, streptococcus pyogenes, haemophilus influenzae, and moraxella catarrhalis from community acquired infections in saitama, japan]. | we examined regional surveillance of antimicrobial susceptibility of community acquired bacterial pathogens from patients in saitama, japan. the fourth-year survey was conducted in three of the period 2007-2010 (period i, 2007-2008; period ii, 2008-2009; period iii, 2009-2010). antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by japanese society of chemotherapy using maximum 13 antibacterial agents. susceptibility testing ... | 2015 | 26742285 |
| the effects of live attenuated influenza vaccine on nasopharyngeal bacteria in healthy 2 to 4 year olds. a randomized controlled trial. | viral infections of the upper respiratory tract may influence the commensal nasopharyngeal bacteria. changes in the bacterial niche could affect transmission dynamics. attenuated vaccine viruses can be used to investigate this empirically in humans. | 2016 | 26742001 |
| comparative analyses of the lipooligosaccharides from nontypeable haemophilus influenzae and haemophilus haemolyticus show differences in sialic acid and phosphorylcholine modifications. | haemophilus haemolyticus and nontypeable haemophilus influenzae (nthi) are closely related upper airway commensal bacteria that are difficult to distinguish phenotypically. nthi causes upper and lower airway tract infections in individuals with compromised airways, while h. haemolyticus rarely causes such infections. the lipooligosaccharide (los) is an outer membrane component of both species and plays a role in nthi pathogenesis. in this study, comparative analyses of the los structures and cor ... | 2016 | 26729761 |
| in vitro activity of gepotidacin, a novel triazaacenaphthylene bacterial topoisomerase inhibitor, against a broad spectrum of bacterial pathogens. | gepotidacin inhibits bacterial dna replication through a mode different from that of fluoroquinolones. gepotidacin and comparators were tested by broth and agar dilution against clinical isolates. the in vitro activities of gepotidacin were comparable against methicillin-susceptible and -resistant staphylococcus aureus (mssa and mrsa, respectively) isolates (mic90, 0.5 μg/ml). the gepotidacin mic90s were as follows (in micrograms per milliliter) for the indicated bacteria: streptococcus pyogenes ... | 2016 | 26729499 |
| histophilus somni genomics and genetics. | histophilus somni is a commensal and an opportunistic bacterial pathogen associated with multisystemic diseases in cattle and sheep. some strains of h. somni isolated from the genital tract of cattle are biochemically and serologically similar to the pathogenic strains, but are relatively innocuous. several virulence factors/mechanisms have been identified in h. somni, of which the phase-variable lipooligosaccharide, induction of apoptosis of host cells, intraphagocytic survival, and immunoglobu ... | 2016 | 26728065 |
| [haemophilus influenzae type b in italy--after thirty years of vaccination may we lower our guard?]. | haemophilus influenzae b (hib) is responsible for meningitis, systemic infections and acute respiratory illness, especially in children. the use of the conjugate vaccines against hib reduced the incidence of the disease worldwide. in italy, after the decrease resulted from vaccination, the disease may reappear due to the reduction in vaccination coverage, the presence of infections in adults and vaccine failures. | 2016 | 26722830 |
| deubiquitinase cyld acts as a negative regulator for bacterium nthi-induced inflammation by suppressing k63-linked ubiquitination of myd88. | myeloid differentiation factor 88 (myd88) acts as a crucial adaptor molecule for toll-like receptors (tlrs) and interleukin (il)-1 receptor signaling. in contrast to the well-studied positive regulation of myd88 signaling, how myd88 signaling is negatively regulated still remains largely unknown. here, we demonstrate for the first time to our knowledge that myd88 protein undergoes lysine 63 (k63)-linked polyubiquitination, which is functionally critical for mediating tlr-myd88-dependent signalin ... | 2016 | 26719415 |
| timing of haemophilus influenzae type b vaccination after cardiac surgery. | the best time for vaccination in infants with congenital heart disease (chd) after cardiopulmonary bypass (cpb) surgery is unclear, but it is important to prevent haemophilus influenzae type b (hib) infection in infants with chd after cpb surgery. to identify the best time for hib vaccination in infants with chd after cpb surgery, we investigated the immunological status, and the efficacy and safety of hib vaccination after cpb surgery. | 2016 | 26718621 |
| the moda10 phasevarion of nontypeable haemophilus influenzae r2866 regulates multiple virulence-associated traits. | non-typeable haemophilus influenzae (nthi) is a human restricted commensal and pathogen that elicits inflammation by adhering to and invading airway epithelia cells: transcytosis across these cells can result in systemic infection. nthi strain r2866 was isolated from the blood of a normal 30-month old infant with meningitis, and is unusual for nthi in that it is able to cause systemic infection. strain r2866 is able to replicate in normal human serum due to expression of lgtc which mimics human ... | 2016 | 26718097 |
| [analysis on clinical and epidemioloical characteristics of measles in hospitalized children in shanghai in 2012]. | to investigate the main factors that influence measles morbidity and the genotype of measles virus, so as to provide evidence for scientific decision making to further control the prevalence of measles. | 2015 | 26717659 |
| detection of bacteria in middle ear effusions based on the presence of allergy: does allergy augment bacterial infection in the middle ear? | bacterial infection, eustachian tube dysfunction, allergies, and immunologic factors are major causes of otitis media with effusion (ome). however, the exact pathogenesis of ome is still unclear. this study evaluated whether allergy influences bacterial growth in middle ear effusions. | 2015 | 26714647 |
| comprehensive proteomic and metabolomic signatures of nontypeable haemophilus influenzae-induced acute otitis media reveal bacterial aerobic respiration in an immunosuppressed environment. | a thorough understanding of the molecular details of the interactions between bacteria and host are critical to ultimately prevent disease. recent technological advances allow simultaneous analysis of host and bacterial protein and metabolic profiles from a single small tissue sample to provide insight into pathogenesis. we used the chinchilla model of human otitis media to determine, for the first time, the most expansive delineation of global changes in protein and metabolite profiles during a ... | 2016 | 26711468 |
| response to immunization in children born to renal transplant recipients using immunosuppressive drugs during gestation. | the use of immunosuppressive drugs can impair vaccination responses. when used during pregnancy, they may interfere with the development of the fetus's immune system. however, little is known regarding their influence on infant's response to vaccinations. twenty-seven children born to renal transplant mothers (tx) taking immunosuppressive drugs and 31 healthy children had the humoral immune response and reactogenicity to tetanus, haemophilus influenzae type b (hib) and 7 pneumococcal serotypes e ... | 2016 | 26707214 |
| epidemiological markers for interactions among streptococcus pneumoniae, haemophilus influenzae, and staphylococcus aureus in upper respiratory tract carriage. | cocolonization by streptococcus pneumoniae and haemophilus influenzae among children has been noted in numerous studies, as has an inverse relationship involving colonization with these species and staphylococcus aureus. interactions among these pathogens could mediate unanticipated outcomes of clinical interventions, including changes in h. influenzae and s. aureus disease incidence following pneumococcal vaccine introduction. however, it remains unclear whether cocolonization patterns represen ... | 2016 | 26704617 |
| polymicrobial intensive care unit-acquired pneumonia: prevalence, microbiology and outcome. | microbial aetiology of intensive care unit (icu)-acquired pneumonia (icuap) determines antibiotic treatment and outcomes. the impact of polymicrobial icuap is not extensively known. we therefore investigated the characteristics and outcomes of polymicrobial aetiology of icuap. | 2015 | 26703094 |
| genomic perspectives on the evolution and spread of bacterial pathogens. | since the first complete sequencing of a free-living organism, haemophilus influenzae, genomics has been used to probe both the biology of bacterial pathogens and their evolution. single-genome approaches provided information on the repertoire of virulence determinants and host-interaction factors, and, along with comparative analyses, allowed the proposal of hypotheses to explain the evolution of many of these traits. these analyses suggested many bacterial pathogens to be of relatively recent ... | 2015 | 26702036 |
| outbreak of a beta-lactam resistant non-typeable haemophilus influenzae sequence type 14 associated with severe clinical outcomes. | during october 2011 several residents and staff members at a long-term care facility (ltcf) for elderly fell ill with respiratory symptoms. several of the residents required hospitalization and one died. non-typeable haemophilus influenzae (nthi) was identified as the causative pathogen. | 2015 | 26700635 |
| polybacterial aetiology and outcomes in patients with community-acquired pneumonia. | community-acquired pneumonia (cap) is a common cause of morbidity and mortality worldwide. while interactions among bacterial pathogens in the respiratory tract have been studied, the impact of polybacterial aetiology on mortality has not been fully elucidated. | 2016 | 26688539 |
| the immunogenicity, safety, and consistency of an indonesia combined dtp-hb-hib vaccine in expanded program on immunization schedule. | who recommended incorporation of haemophilus influenzae type b (hib) vaccination into immunization program. indonesia would adopt hib as a national immunization program in 2013. we aimed at analyzing immunogenicity, safety, and consistency of a new combined dtp-hb-hib (diphtheria-tetanus-pertussis-hepatitis b-haemophilus influenza b) vaccine. | 2015 | 26686508 |
| contribution of pbp3 substitutions and tem-1, tem-15, and rob-1 beta-lactamases to cefotaxime resistance in haemophilus influenzae and haemophilus parainfluenzae. | to investigate the relative contributions of naturally occurring penicillin-binding protein 3 (pbp3) substitutions, and tem-1, tem-15, and rob-1 beta-lactamases on resistance to a third-generation cephalosporin in haemophilus influenzae and haemophilus parainfluenzae. | 2016 | 26683319 |
| a small volume technique to examine and compare alveolar macrophage phagocytosis of apoptotic cells and non typeable haemophilus influenzae (nthi). | a defective ability of alveolar macrophages to phagocytose both apoptotic airway epithelial cells and bacteria in chronic lung diseases potentially associated with inflammation and bacterial colonisation of the lower airways, often with non-typeable haemophilus influenzae (nthi), has been shown. we routinely assess phagocytosis in the airway of children: however, the small volume of bal obtained usually precludes the investigation of phagocytosis of both (potentially equally relevant) apoptotic ... | 2016 | 26678160 |
| serum concentrations of antibodies against outer membrane protein p6, protein d, and t- and b-cell combined antigenic epitopes of nontypeable haemophilus influenzae in children and adults of different ages. | nontypeable haemophilus influenzae (nthi) is one of the most common etiologies of acute otitis media, rhinosinusitis, and pneumonia. outer membrane proteins (omps) are the main focus in new vaccine development against nthi, as the h. influenzae type b (hib) vaccine does not cover noncapsulated nthi. the omps p6 and protein d are the most promising candidate antigens for an nthi vaccine, and low antibody levels against them in serum may be correlated with infection caused by nthi. in the current ... | 2015 | 26677200 |
| nontypeable haemophilus influenzae-induced myd88 short expression is regulated by positive ikkβ and creb pathways and negative erk1/2 pathway. | airway diseases such as asthma and chronic obstructive pulmonary disease (copd) are characterized by excessive inflammation and are exacerbated by nontypeable haemophilus influenzae (nthi). airway epithelial cells mount the initial innate immune responses to invading pathogens and thus modulate inflammation. while inflammation is necessary to eliminate a pathogen, excessive inflammation can cause damage to the host tissue. therefore, the inflammatory response must be tightly regulated and deciph ... | 2015 | 26669856 |
| genotyping of haemophilus influenzae type b strains and their incidence in the clinical samples isolated from iranian patients. | haemophilus influenzae type b (hib) is divided into two distinct genotypes, type i and type ii, based on the structure of capsular polysaccharides. the capsulation locus of haemophilus influenzae type b consists of three functionally distinct regions, designated regions 1 to 3. region iii contains hcsa and hcsb genes; however, notable sequence variation in this region can be used to recognize different hib genotypes. the purpose of this study was to investigate the prevalence and genotype of the ... | 2015 | 26668700 |
| antimicrobial susceptibility trends among gram-positive and -negative clinical isolates collected between 2005 and 2012 in mexico: results from the tigecycline evaluation and surveillance trial. | the tigecycline evaluation and surveillance trial (t.e.s.t) is a global antimicrobial surveillance study of both gram-positive and gram-negative organisms. this report presents data on antimicrobial susceptibility among organisms collected in mexico between 2005 and 2012 as part of t.e.s.t., and compares rates between 2005-2007 and 2008-2012. | 2015 | 26667651 |
| nasopharyngeal carriage of streptococcus pneumoniae and other bacteria in the 7th year after implementation of the pneumococcal conjugate vaccine in the netherlands. | after introduction of the 7-valent pneumococcal conjugate vaccine (pcv7) in the infant national immunization program (nip) in the netherlands in 2006, streptococcus pneumoniae strains of the non-vaccine serotype 19a emerged and became the dominant serotype in carriage in children and their parents. similar patterns were observed in other european countries and the united states. increases in carriage rates of staphylococcus aureus and non-typeable (nt) haemophilus influenzae were also observed. ... | 2016 | 26667610 |
| distribution of pathogens causing nosocomial infection in patients with bronchial asthma. | this study aimed to analyze nosocomial respiratory infection (nri) in patients with bronchial asthma. among the clinical data of 575 asthmatic patients that was collected and analyzed, 52 were diagnosed with nri. the most common gram-positive bacterial species was streptococcus pneumoniae, which was detected in 8 patients, whereas the predominant gram-negative bacteria included haemophilus influenzae (11 patients), moraxella catarrhalis (8 patients), and escherichia coli (7 patients). the simult ... | 2015 | 26662406 |
| platelet-activating factor receptor (pafr) is upregulated in small airways and alveoli of smokers and copd patients. | pafr is a cell adhesion site for specific bacteria, notably non-typeable haemophilus influenzae (nthi) and streptococcus pneumoniae. we previously published that pafr expression is significantly upregulated in the large airways of smokers, especially in copd. we have now investigated pafr expression in the epithelium and rbm of small airways and in the alveolar compartment in smokers and patients with both copd and small airway disease. | 2016 | 26662379 |
| estimated costs attributable to events of "out-of-temperature" in the stockpiling of hexavalent vaccines occurring in italy. | antigens contained in vaccines are inherently unstable biologically; such a characteristic is conferred by their three-dimensional structure. preserving the ability of the vaccines to protect against disease is necessary to ensure the supervision and monitoring of all steps of the cold chain. dtpa-hbv-ipv/hib vaccine (infanrix hexatm, gsk vaccines, belgium) is designed to prevent disease due to diphtheria, tetanus, pertussis (dtp), hepatitis b virus (hbv), poliomyelitis and haemophilus influenza ... | 2015 | 26661911 |
| direct comparison of immunogenicity induced by 10- or 13-valent pneumococcal conjugate vaccine around the 11-month booster in dutch infants. | since 2009/10, a 10- and a 13-valent pneumococcal conjugate vaccine (pcv) are available, but only the 10-valent vaccine is now being used for the children in the netherlands. as the vaccines differ in number of serotypes, antigen concentration, and carrier proteins this study was designed to directly compare quantity and quality of the antibody responses induced by pcv10 and pcv13 before and after the 11-month booster. | 2015 | 26658902 |
| urethritis-associated pathogens in urine from men with non-gonococcal urethritis: a case-control study. | the aetiology of non-gonococcal urethritis (ngu) remains unexplained in 30-40% of patients. urine samples from men attending swedish sexually transmitted disease clinics were examined by species-specific quantitative pcrs for chlamydia trachomatis, mycoplasma genitalium, trichomonas vaginalis, ureaplasma urealyticum, u. parvum, adenovirus, herpes simplex virus, neisseria meningitidis, haemophilus influenzae, moraxella catarrhalis and streptococcus pneumoniae. a total of 187 men with acute ngu (s ... | 2016 | 26658669 |
| impact of meteorological factors on lower respiratory tract infections in children. | to evaluate retrospectively the relationship between meteorological factors in shenmu county, yulin city, shaanxi province, china and the incidence of lower respiratory tract infections in children. | 2016 | 26658270 |
| airway dysbiosis: haemophilus influenzae and tropheryma in poorly controlled asthma. | asthma is a chronic inflammatory disorder of the airways where bacteria may act as protagonists of chronic inflammation. little is known about the relation of airway inflammation to the presence of specific bacterial taxa. we sought to describe the sputum microbiome in adults with poorly controlled asthma.dna was extracted from induced sputum and microbial communities were profiled using 16s rrna pyrosequencing. bacterial species were characterised, and the relationship between microbial populat ... | 2016 | 26647445 |
| nqrm (duf539) protein is required for maturation of bacterial na+-translocating nadh:quinone oxidoreductase. | na(+)-translocating nadh:quinone oxidoreductase (na(+)-nqr) catalyzes electron transfer from nadh to ubiquinone in the bacterial respiratory chain, coupled with na(+) translocation across the membrane. na(+)-nqr maturation involves covalent attachment of flavin mononucleotide (fmn) residues, catalyzed by flavin transferase encoded by the nqr-associated apbe gene. analysis of complete bacterial genomes has revealed another putative gene (duf539, here renamed nqrm) that usually follows the apbe ge ... | 2016 | 26644436 |
| haemophilus influenzae induces steroid-resistant inflammatory responses in copd. | chronic obstructive pulmonary disease (copd) is an inflammatory disorder partially resistant to glucocorticoids. a reduced histone deacetylase (hdac) activity has been proposed to explain this resistance. haemophilus influenzae frequently colonizes the airways of copd patients, where it enhances inflammation. the effects of haemophilus influenzae on hdac activity have not been investigated before. | 2015 | 26642881 |
| regional specifics of microbial landscape in outpatients with lower respiratory tract infections. | the last years have witnessed progressive growth of antimicrobial resistance (amr) both in hospital-acquired and community-acquired respiratory infections. regional guidelines (2006) presented standard approaches to pharmacotherapy and provided an important contribution to improvement of antimicrobial therapy at healthcare facilities of both the city of stavropol and the stavropol region. at the same time, recent years have witnessed substantial changes in sensitivity to antimicrobials; besides, ... | 2015 | 26639714 |
| protracted bacterial bronchitis: the last decade and the road ahead. | cough is the single most common reason for primary care physician visits and, when chronic, a frequent indication for specialist referrals. in children, a chronic cough (>4 weeks) is associated with increased morbidity and reduced quality of life. one common cause of childhood chronic cough is protracted bacterial bronchitis (pbb), especially in children aged <6 years. pbb is characterized by a chronic wet or productive cough without signs of an alternative cause and responds to 2 weeks of appro ... | 2016 | 26636654 |
| crystal structure and kinetic studies of a tetrameric type ii β-carbonic anhydrase from the pathogenic bacterium vibrio cholerae. | carbonic anhydrase (ca) is a zinc enzyme that catalyzes the reversible conversion of carbon dioxide to bicarbonate (hydrogen carbonate) and a proton. cas have been extensively investigated owing to their involvement in numerous physiological and pathological processes. currently, ca inhibitors are widely used as antiglaucoma, anticancer and anti-obesity drugs and for the treatment of neurological disorders. recently, the potential use of ca inhibitors to fight infections caused by protozoa, fung ... | 2015 | 26627652 |
| effects of rhinovirus infection on nasopharyngeal bacterial colonization in infants with wild or variant types of mannose-binding lectin and toll-like receptors 3 and 4. | development of respiratory tract infections is determined by interactions between viruses, bacteria, and the host innate immune response. we investigated the impact of natural rhinovirus infection on nasopharyngeal bacterial colonization in infants with or without gene polymorphisms of mannose-binding lectin (mbl) and toll-like receptors (tlrs) 3 and 4. | 2013 | 26619478 |
| interactions of conjugate vaccines and co-administered vaccines. | conjugate vaccines play an important role in the prevention of infectious diseases such as those caused by the bacteria haemophilus influenzae (hi) type b (hib), neisseria meningitidis, and streptococcus pneumoniae. vaccines developed against these 3 pathogens utilize 3 main carrier proteins, non-toxic mutant of diphtheria toxin (crm197), diphtheria toxoid (dt) and tetanus toxoid (tt). current pediatric immunisation schedules include the administration of several vaccines simultaneously, therefo ... | 2015 | 26619353 |
| vaccine hesitancy: causes, consequences, and a call to action. | vaccine hesitancy reflects concerns about the decision to vaccinate oneself or one's children. there is a broad range of factors contributing to vaccine hesitancy, including the compulsory nature of vaccines, their coincidental temporal relationships to adverse health outcomes, unfamiliarity with vaccine-preventable diseases, and lack of trust in corporations and public health agencies. although vaccination is a norm in the u.s. and the majority of parents vaccinate their children, many do so am ... | 2015 | 26615171 |
| prevention and control of childhood pneumonia and diarrhea. | pneumonia and diarrhea are the 2 leading infectious causes of death in children younger than 5 years worldwide, most of which occur in low- and middle-income countries (lmics) in sub-saharan africa and southern asia. the past decade has seen large reductions in global childhood mortality, partly due to expansion of nonspecific public health interventions and vaccines against streptococcus pneumoniae, haemophilus influenzae, and rotavirus in lmics. further progress in this field depends on the in ... | 2016 | 26613689 |