Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| macrophage genetic reprogramming during chronic peritonitis is augmented by lps pretreatment. | background: persistent and tertiary chronic peritonitis is a clinically challenging problem especially in those who are critically ill. this could be attributed to a state of immune-paralysis, known as microbial tolerance. microbial tolerance is the diminished pro-inflammatory protein response following repeated stimulation by numerous pathogen-associated molecular patterns (pamps) of varying origins, which we have shown in this novel model of chronic peritonitis. we aimed in this study to inves ... | 2011 | 21696761 |
| potential role of tigecycline in the treatment of community-acquired bacterial pneumonia. | tigecycline is a member of the glycylcycline class of antimicrobials, which is structurally similar to the tetracycline class. it demonstrates potent in vitro activity against causative pathogens that are most frequently isolated in patients with community-acquired bacterial pneumonia (cabp), including (but not limited to) streptococcus pneumoniae (both penicillin-sensitive and -resistant strains), haemophilus influenzae and moraxella catarrhalis (including +¦-lactamase-producing strains), klebs ... | 2011 | 21694911 |
| deep neck abscess: an analysis of microbial etiology and the effectiveness of antibiotics. | the objective was to demonstrate the aerobic and anaerobic microbiology of deep neck space abscess and to analyze the coverage rate of different empiric antimicrobial agents. a retrospective review of hospitalized patients with deep neck abscess diagnosed at a tertiary-care, general hospital between april 2001 and october 2006. the study enrolled 100 patients. the bacterial cultures of 89 patients yielded positive results (89%). the predominant aerobes were viridans streptococci, klebsiella pneu ... | 2008 | 21694873 |
| fluoroquinolone resistance in escherichia coli and klebsiella pneumoniae over 18 years: effect of different systems for eliminating duplicates. | 2011 | 21693462 | |
| impact of a clonal outbreak of extended-spectrum {beta}-lactamase-producing klebsiella pneumoniae in the development and evolution of bloodstream infections by k. pneumoniae and escherichia coli: an 11 year experience in oxfordshire, uk. | objectives the objectives of this study were: (i) to describe an outbreak of multidrug-resistant klebsiella pneumoniae in our population; (ii) to identify the potential source of this outbreak by examining antibiotic resistance trends in urocultures; (iii) to evaluate the contribution of this outbreak to resistance patterns over time in the two commonest gram-negative blood culture isolates, namely k. pneumoniae and escherichia coli; and (iv) to assess risk factors for multidrug resistance and t ... | 2011 | 21693458 |
| bactericidal activity identified in 2s albumin from sesame seeds and in silico studies of structure-function relations. | pathogenic bacteria constitute an important cause of hospital-acquired infections. however, the misuse of available bactericidal agents has led to the appearance of antibiotic-resistant strains. thus, efforts to seek new antimicrobials with different action mechanisms would have an enormous impact. here, a novel antimicrobial protein (siamp2) belonging to the 2s albumin family was isolated from sesamum indicum kernels and evaluated against several bacteria and fungi. furthermore, in silico analy ... | 2011 | 21691771 |
| the challenges of antimicrobial drug resistance in greece. | antimicrobial drug resistance rates in greece are among the highest in europe. the prevalence of carbapenem-resistant gram-negative species has increased considerably, including endemic strains in intensive care units. pandrug-resistant klebsiella pneumoniae, acinetobacter baumannii, and pseudomonas aeruginosa are sporadically reported. methicillin-resistant staphylococcus aureus and vancomycin-resistant enterococcus rates are also high in greek hospitals. multidrug resistance increases risk of ... | 2011 | 21690626 |
| genetic evolution and clinical impact in extended-spectrum +¦-lactamase-producing escherichia coli and klebsiella pneumoniae. | the emergence of extended-spectrum +¦-lactamase (esbl)-producing bacteria, particularly escherichia coli and klebsiella pneumoniae, is now a critical concern for the development of therapies against bacterial infection. esbls consist of three major genetic groups: tem, shv, and ctx-m types. nosocomial infections due to tem and shv-producing k. pneumoniae strains were frequently documented until the late 1990s. the number of reports on community-acquired infections caused by ctx-m-producing e. co ... | 2011 | 21689785 |
| does it ever make sense to treat a bacterial infection with a drug against which the responsible pathogen possesses a resistance mechanism? | 2011 | 21689208 | |
| results of urine culture and antimicrobial sensitivity tests according to the voiding method over 10 years in patients with spinal cord injury. | we studied the results of urine cultures and antimicrobial sensitivity tests according to the voiding method used by spinal cord injury (sci) patients over a recent 10-year period. | 2011 | 21687395 |
| gas forming liver abscess caused by klebsiella pneumoniae. | 2009 | 21686710 | |
| mucosal surveillance cultures in predicting gram-negative late-onset sepsis in neonatal intensive care units. | this study aimed to examine the spectrum and time course of gut and nasopharyngeal colonization with gram-negative micro-organisms, and to define the value of surveillance cultures in predicting late-onset sepsis in neonates admitted to neonatal intensive care units. nasopharyngeal and rectal swabs were collected on admission and twice weekly thereafter in 278 neonates admitted within the first 72-áh of life with risk factors of early-onset sepsis. sterile body fluid cultures were obtained on ad ... | 2011 | 21684633 |
| clinical and economic burden of community-acquired pneumonia amongst adults in the asia-pacific region. | community-acquired pneumonia (cap) is an important cause of mortality and morbidity amongst adults in the asia-pacific region. literature published between 1990 and may 2010 on the clinical and economic burden of cap amongst adults in this region was reviewed. cap is a significant health burden with significant economic impact in this region. chronic obstructive pulmonary disease, cardiovascular disease, diabetes mellitus and advanced age were risk factors for cap. aetiological agents included s ... | 2011 | 21683553 |
| production of a novel bioflocculant mnxy1 by klebsiella pneumoniae strain ny1 and application in precipitation of cyanobacteria and municipal wastewater treatment. | aims:ôçé to isolate and characterize the novel bioflocculant-producing bacteria, to optimize the bioflocculant production and to evaluate its potential applications. methods and results:ôçé klebsiella pneumoniae strain ny1, a bacterium that produces a novel bioflocculant (mnxy1), was selected on the chemically defined media. it was classified according to the 16s rrna gene sequence, morphological and microscopic characteristics. mnxy1 was characterized to contain 26% protein and 66% total sugar. ... | 2011 | 21679283 |
| emerging severe and fatal infections due to klebsiella pneumoniae in two university hospitals in france. | severe infections caused by hypermucoviscous klebsiella pneumoniae have been reported in southeast asian countries over the past several decades. this report shows their emergence in france, with 12 cases observed during a 2-year period in two university hospitals. two clones (sequence type 86 [st86] and st380) of serotype k2 caused five rapidly fatal bacteremia cases, three of which were associated with pneumonia, whereas seven liver abscess cases were caused by k1 strains of st23. | 2011 | 21677064 |
| wide dissemination of extended-spectrum beta-lactamase (esbl)-producing escherichia coli and klebsiella spp. in acute care and rehabilitation hospitals. | summarya prospective surveillance system for extended-spectrum beta-lactamase-producing escherichia coli (esbl-e) and esbl-producing klebsiella spp. (esbl-k) was implemented in 39 german hospitals with the aim of determining the incidence densities (ids) of community-onset and hospital-onset cases and of identifying risk factors for high ids of hospital-onset cases. during 2008, 2081 esbl-e/k cases were documented. esbl-e cases (n=1330, 63-à9%) were more common than esbl-k cases (n=751, 36-à1%), ... | 2011 | 21676355 |
| synthesis of silver nanoparticles in montmorillonite and their antibacterial behavior. | silver nanoparticles (ag nps) were synthesized by the chemical reducing method in the external and interlamellar space of montmorillonite (mmt) as a solid support at room temperature. agno(3) and nabh(4) were used as a silver precursor and reducing agent, respectively. the most favorable experimental conditions for synthesizing ag nps in the mmt are described in terms of the initial concentration of agno(3). the interlamellar space limits changed little (d-spacing = 1.24-1.47 nm); therefore, ag ... | 2011 | 21674015 |
| multiresistance, beta-lactamase-encoding genes and bacterial diversity in hospital wastewater in rio de janeiro, brazil. | aims:ôçé to investigate the bacterial diversity, antimicrobial resistance patterns and types of beta-lactamase genes in gram-negative bacteria isolated from a hospital sewage treatment plant. methods and results:ôçé between july and december 2008, we collected samples from influent, clarifier tank effluent and chlorine contact tank effluent from a sewage treatment plant service of a hospital located in the city of rio de janeiro, brazil. of the 221 isolates identified, 40% were characterized as ... | 2011 | 21672095 |
| susceptibility of klebsiella pneumoniae isolates from intra-abdominal infections and molecular characterization of ertapenem-resistant isolates. | a total of 2,841 clinical isolates of klebsiella pneumoniae from intra-abdominal infections worldwide were collected in the study for monitoring antimicrobial resistance trends (smart) during 2008 and 2009. overall, 22.4% of isolates had extended-spectrum ╬▓-lactamases (esbls). the most active antibiotics among the 11 tested were imipenem, amikacin, and ertapenem, though even these, like all other comparators, were less consistently active against esbl-positive isolates than against esbl-negativ ... | 2011 | 21670192 |
| antimicrobial susceptibilities of commonly encountered bacterial isolates to fosfomycin determined by agar dilution and disk diffusion methods. | we studied the antimicrobial activity of fosfomycin against 960 strains of commonly encountered bacteria associated with urinary tract infection using standard agar dilution and disk diffusion methods. species studied included 3 common species of enterobacteriaceae, pseudomonas aeruginosa, acinetobacter baumannii, and stenotrophomonas maltophilia; methicillin-susceptible and -resistant staphylococcus aureus; and vancomycin-susceptible and resistant enterococcus faecalis and e. faecium. mics and ... | 2011 | 21670185 |
| consensus review of the epidemiology and appropriate antimicrobial therapy of complicated urinary tract infections in asia-pacific region. | urinary tract infections (utis) are among the most prevalent infectious diseases in the general population. they cause a substantial financial burden in the community and are associated with significant morbidity and mortality, particularly in hospitals. with increased rates of antimicrobial resistance, especially in the asia-pacific region, treatment of complicated utis (cutis) can be challenging for clinicians. consideration of an optimal antimicrobial agent should be based on local resistance ... | 2011 | 21669223 |
| pyogenic liver abscess in older adults: comparison with younger individuals. | 2011 | 21668934 | |
| outbreak of kpc-3-producing, and colistin-resistant, klebsiella pneumoniae infections in two sicilian hospitals. | clin microbiol infect 2011; 17: 1444-1447 abstract: we report the first outbreak caused by colistin-resistant klebsiella pneumoniae producing kpc-3 carbapenamase in two italian hospitals. this spread occurred in 1-ámonth, and was caused by eight colistin-resistant and carbapenem-resistant klebsiella pneumoniae isolates from eight patients. a further three isolates were obtained from the intestinal tract and pharyngeal colonization. all isolates were multidrug-resistant (mdr), including being res ... | 2011 | 21668577 |
| microbial pathogens causative of neonatal sepsis in arabic countries. | neonatal sepsis is a major cause of morbidity and mortality worldwide. we analyzed the spectrum of pathogens causing neonatal sepsis in various arabic countries. | 2011 | 21668322 |
| [bacteraemia due to escherichia coli producing extended-spectrum beta-lactamases (esbl): clinical relevance and today's insights]. | antibiotic resistance is an old problem with new face as the rate of infections due to multidrug resistant bacteria is higher everyday and the number of new antibiotics to overwhelm the problem is becoming smaller. e. coli is the most frequent agent causing nosocomial or community-acquired bacteraemia being in our country 10% of them extended-spectrum beta-lactamases (esbl) producing e. coli isolates. nowadays the number of community- acquired or health-related infections caused by these esbl pr ... | 2011 | 21666996 |
| institutional control measures to curtail the epidemic spread of carbapenem-resistant klebsiella pneumoniae: a 4-year perspective. | to describe the implementation of an institution-wide, multiple-step intervention to curtail the epidemic spread of carbapenem-resistant klebsiella pneumoniae (crkp). | 2011 | 21666398 |
| addition of genes for cellobiase and pectinolytic activity in escherichia coli for fuel ethanol production from pectin-rich lignocellulosic biomass. | ethanologenic escherichia coli strain ko11 was sequentially engineered to contain the klebsiella oxytoca cellobiose phosphotransferase genes (casab) as well as a pectate lyase (pele) from erwinia chrysanthemi, yielding strains ly40a (casab) and jp07 (casab pele), respectively. to obtain an effective secretion of pele, the sec-dependent pathway out genes from e. chrysanthemi were provided on a cosmid to strain jp07 to construct strain jp07c. finally, oligogalacturonide lyase (ogl) from e. chrysan ... | 2011 | 21666025 |
| diversity and phylogeny of bacteria on zimbabwe tobacco leaves estimated by 16s rrna sequence analysis. | microorganisms play important roles in the tobacco aging process. however, microbial communities on flue-cured tobacco leaves (fctl) remain largely unknown. in this study, the total microbial genomic dna of unaged and aging fctl from zimbabwe were isolated using a culture-independent method, and the bacterial communities were investigated through analyzing two 16s rrna gene libraries. eighty-four and 65 operational taxonomic units were obtained from the libraries of the unaged and aging fctl, re ... | 2011 | 21660545 |
| effect of antibiotic diversity on ventilator-associated pneumonia caused by eskape organisms. | the aim of this study was to test in the clinic whether antimicrobial diversity affects resistance of enterococcus faecium, staphylococcus aureus, klebsiella species, acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter species (eskape) pathogens in ventilator-associated pneumonia (vap). | 2011 | 21659436 |
| hemoperfusion treatment in a septic shock patient with autosomal dominant polycystic kidney disease and increased hmgb1 protein levels. | this case report describes polymyxin b-immobilized fiber (pmx-f) treatment of septic shock caused by pyelonephritis in a 68-year-old woman with autosomal dominant polycystic kidney disease. she was admitted for severe lower left abdominal pain, high fever (40°c) and gross hematuria. her endotoxin and high-mobility group box-1 protein (hmgb1) levels were extremely elevated. her blood pressure was 68/36 mm hg. urinalysis revealed innumerable white blood cells (wbcs). blood and urine cultures were ... | 2011 | 21654166 |
| endotipsitis: a diagnostic challenge. | 2011 | 21654138 | |
| correlation of tem, shv and ctx-m extended-spectrum beta lactamases among enterobacteriaceae with their in vitro antimicrobial susceptibility. | the present study was carried out to characterize the esbl types and evaluated their in vitro activity against a collection of gram negative bacteria (gnb) from a multicentric indian surveillance study. | 2011 | 21654112 |
| an outbreak of ctx-m-15-producing klebsiella pneumoniae isolates in an intensive care unit of a teaching hospital in kuwait. | this study reports an outbreak of klebsiella pneumoniae infections in 14 patients during a 2-month period (august-september, 2008) in the intensive care unit (icu) of a teaching hospital in kuwait. | 2011 | 21654106 |
| early detection of colonization by vim-1-producing klebsiella pneumoniae and ndm-1-producing escherichia coli in two children returning to france. | rapid identification of metallo-β-lactamase-producing gram-negative species is crucial for the timely implementation of infection control measures. we describe two pediatric cases in which colonization by vim-1- and new delhi metallo-beta-lactamase 1-producing enterobacteriaceae was rapidly detected by phenotypic and genotypic methods. phenotypic methods can be useful for routine detection of carbapenemase production. | 2011 | 21653781 |
| multilocus sequence typing of incn plasmids. | objectives incompatibility group n (incn) plasmids have been associated with the dissemination of antimicrobial resistance and are a major vehicle for the spread of bla(vim-1) in humans and bla(ctx-m-1) in animals. a plasmid multilocus sequence typing (pmlst) scheme was developed for rapid categorization of incn plasmids. methods twelve fully sequenced incn plasmids available at genbank were analysed in silico for selecting the loci for the incn-specific pmlst. a total of 58 plasmids originating ... | 2011 | 21653604 |
| carbapenem-resistant enterobacteriaceae: epidemiology and prevention. | over the past 10 years, dissemination of klebsiella pneumoniae carbapenemase (kpc) has led to an increase in the prevalence of carbapenem-resistant enterobacteriaceae (cre) in the united states. infections caused by cre have limited treatment options and have been associated with high mortality rates. in the previous year, other carbapenemase subtypes, including new delhi metallo-β-lactamase, have been identified among enterobacteriaceae in the united states. like kpc, these enzymes are frequent ... | 2011 | 21653305 |
| country-to-country transfer of patients and the risk of multi-resistant bacterial infection. | management of patients with a history of healthcare contact in multiple countries is now a reality for many clinicians. leisure tourism, the burgeoning industry of medical tourism, military conflict, natural disasters, and changing patterns of human migration may all contribute to this emerging epidemiological trend. such individuals may be both vectors and victims of healthcare-associated infection with multiresistant bacteria. current literature describes intercountry transfer of multiresistan ... | 2011 | 21653302 |
| microstructured cystine dendrites-based impedimetric sensor for nucleic acid detection. | we report results of the studies relating to the fabrication and characterization of novel biosensing electrode by covalent immobilization of dna onto microstructural cystine (cys) prepared by acoustic cavitation method. the tem investigations of these structures reveal transformation of microstructured cys from nanorods to dendritic structure under optimum conditions. the cys dendrites (dencys) have been investigated by xrd, ft-ir, and sem studies. these biosensing electrodes have been fabricat ... | 2011 | 21650182 |
| [comparison of 2,3-butanediol production by several strains and optimization of the fermentation medium]. | five klebsiella pneumonia strains (including two strains whose genes for lactic acid were knocked out) were used to produce 2,3-butanediol, in which k. pneumonia hr521 ldh (gene for lactic acid was knocked out) was the best for the production, and then the fermentation medium was optimized by orthogonal design. the optimum compositions were as follows: glucose 90 g/l, (nh4)2hpo4 3 g/l, clsp 6 g/l, sodium acetate 5 g/l, kcl 0.4 g/l, mgso4 0.1 g/l, feso4 x 7h2o 0.02 g/l, mnso4 0.01 g/l. under the ... | 2011 | 21650032 |
| community acquired pneumonia in port harcourt rivers state of nigeria. | community acquired pneumonia (cap) is a major cause of death world wide. knowledge of the likely pathogens and their sensitivity/resistance pattern can help in the choice of antibiotic therapy and improve outcome. | 2008 | 21648126 |
| synthesis of 4-hydroxycoumarin heteroarylhybrids as potential antimicrobial agents. | a new series of 4-hydroxycoumarin derivatives 3a-d was synthesized by the reaction of 3-bromo-4-hydroxy coumarin 1 with various heteroaldehydes 2a-d in good yields. the synthesized compounds were characterized on the basis of their elemental and spectral (ir, (1) h-nmr and mass spectrometry) analysis. all target compounds were evaluated for their in-vitro antimicrobial activity against streptococcus pyogenes, methicillin-resistant staphylococcus aureus, pseudomonas aeruginosa, klebsiella pneumon ... | 2011 | 21647940 |
| the impact of a nationwide antibiotic restriction program on antibiotic usage and resistance against nosocomial pathogens in turkey. | purpose: antimicrobial resistance among microorganisms is a global concern. in 2003, a nationwide antibiotic restriction program (narp) was released in turkey. in this study we evaluated the effect of narp on antibiotic consumption, antimicrobial resistance, and cost.materials and methods: the data obtained from all of the four university hospitals, and one referral tertiary-care educational state hospital in ankara. antimicrobial resistance profiles of 14,233 selected microorganisms all grown i ... | 2011 | 21647326 |
| synergistic antibacterial effects of polyphenolic compounds from olive mill wastewater. | polyphenols or phenolic compounds are groups of secondary metabolites widely distributed in plants and found in olive mill wastewater (omw). phenolic compounds as well as omw extracts were evaluated in vitro for their antimicrobial activity against gram-positive (streptococcus pyogenes and staphylococcus aureus) and gram-negative bacteria (escherichia coli and klebsiella pneumoniae). most of the tested phenols were not effective against the four bacterial strains when tested as single compounds ... | 2011 | 21647315 |
| asymptomatic bacteriuria and antibacterial susceptibility patterns in an obstetric population. | introduction. asymptomatic bacteriuria (asb), occurring in 2-11% of pregnancies, is a major predisposition to the development of pyelonephritis, which is associated with obstetrical complications, such as preterm labor and low birth weight infants. the aim of this study was to determine the prevalence of asb, the antibacterial susceptibilities of the isolated microorganisms and the associated risk factors in an outpatient clinical setting in zekai tahir burak women's health education and researc ... | 2011 | 21647231 |
| expression of a clostridium perfringens type iv pilin by neisseria gonorrhoeae mediates adherence to muscle cells. | clostridium perfringens is an anaerobic, gram-positive bacterium that causes a range of diseases in humans, including lethal gas gangrene. we have recently shown that strains of c. perfringens move across the surface of agar plates using a unique type iv pili (tfp)-mediated social motility that had not been previously described. based on sequence homology to pilins in gram-negative bacteria, c. perfringens appears to have two pilin subunits, pila1 and pila2. structural prediction analysis indica ... | 2011 | 21646450 |
| biofilm formation as a function of adhesin, growth medium, substratum and strain type. | biofilm formation is involved in the majority of bacterial infections. comparing six escherichia coli and klebsiella pneumoniae isolates revealed significant differences in biofilm formation depending on the growth medium. fimbriae are known to be involved in biofilm formation, and type 1, f1c and p fimbriae were seen to influence biofilm formation significantly different depending on strain background, growth media and aeration as well as surface material. altogether, this report clearly demons ... | 2011 | 21646046 |
| assessing the effect of oxygen and microbial inhibitors to optimize ferricyanide-mediated bod assay. | methods for short-term bod analysis (bod(st)) based on ferricyanide mediator reduction have succeeded in overcoming some problems associated with the standard bod test analysis (bod(5)) such as long-term incubations (5 days), the need to dilute samples and low reproducibility. here we present a bioassay where a klebsiella pneumoniae environmental strain successfully reduces ferricyanide without de-aeration of the samples with linear bod(5) ranges between 30 and 500mgl(-1) or 30 and 200mgl(-1), u ... | 2011 | 21645725 |
| klebsiella pneumoniae producing kpc carbapenemase in a district general hospital in the uk. | we report two patients with multidrug-resistant kpc-carbapenemase-producing klebsiella pneumoniae urinary tract infections. a bla(kpc-2) gene was detected in both of the isolates by polymerase chain reaction and sequencing. the isolates had identical pulsed-field gel electrophoresis patterns and belonged to sequence type st11. the index patient probably acquired the kpc-producing strain while in hospital in curaçao, with subsequent nosocomial transmission to the second patient occurring in our h ... | 2011 | 21641083 |
| studies on interaction of colloidal silver nanoparticles (snps) with five different bacterial species. | silver nanoparticles (snps) are being increasingly used in many consumer products like textile fabrics, cosmetics, washing machines, food and drug products owing to its excellent antimicrobial properties. here we have studied the adsorption and toxicity of snps on bacterial species such as pseudomonas aeruginosa, micrococcus luteus, bacillus subtilis, bacillus barbaricus and klebsiella pneumoniae. the influence of zeta potential on the adsorption of snps on bacterial cell surface was investigate ... | 2011 | 21640562 |
| carbapenemase-producing klebsiella pneumoniae: (when) might we still consider treating with carbapenems? | clin microbiol infect 2011; 00: 000-000 abstract: infections caused by carbapenemase-producing klebsiella pneumoniae (cpkp) are increasing in frequency worldwide. cpkp isolates exhibit extensive drug resistance phenotypes, complicate therapy, and limit treatment options. although cpkp isolates are often highly resistant to carbapenems, a proportion of these have relatively low mics for carbapenems, raising the question of whether this class of agents has any therapeutic potential against cpkp in ... | 2011 | 21635663 |
| [effect of heavy metal ions on triphenyltin enzymatic degradation]. | the influence of different metal ions and different forms of addition on triphenyltin enzymatic degradation was investigated under conditions using enzyme obtained from klebsiella pneumoniae. the objective of this study is to illuminate the mechanism of enzymatic degradation of triphenyltin (tpht). the results demonstrated that the strain was able to tolerate k+, mg2+, cu2+, ca2+ and fe3+ at high concentrations. high concentrations of zn2+ and fe2+ had some toxic effects on the strain, thus affe ... | 2011 | 21634178 |
| bacteriology of deep neck abscesses: a retrospective review of 96 consecutive cases. | introduction: this study aimed to review the microbiology of deep neck abscesses and identify the factors that influence their occurrence. methods: a retrospective chart review was done of patients diagnosed with deep neck abscesses at the department of otorhinolaryngology, tan tock seng hospital, singapore between 2004 and 2009. the data of 131 deep neck abscess patients were reviewed, and those with positive pus culture were included in the study. logistic regression was applied to analyse and ... | 2011 | 21633769 |
| comparative evaluation of boronic acid combined-disk tests for the detection of kpc carbapenemase-producing enterobacteriaceae clinical isolates. | the accurate phenotypic detection of kpc-producing enterobacteriaceae is an increasing necessity worldwide. we evaluated the performance of boronic acid combined-disk tests using as substrate impenem or meropenem and as inhibitor of kpc production 300 μg aminophenylboronic acid (apba), 600 μg apba or 400 μg phenylboronic acid (pba). tests were considered positive when an increase in the growth-inhibitory zone around carbapenem disk with kpc inhibitor was 5 mm or greater of the growth-inhibitory ... | 2011 | 21632901 |
| pcr-based identification of klebsiella pneumoniae subsp. rhinoscleromatis, the agent of rhinoscleroma. | rhinoscleroma is a chronic granulomatous infection of the upper airways caused by the bacterium klebsiella pneumoniae subsp. rhinoscleromatis. the disease is endemic in tropical and subtropical areas, but its diagnosis remains difficult. as a consequence, and despite available antibiotherapy, some patients evolve advanced stages that can lead to disfiguration, severe respiratory impairment and death by anoxia. because identification of the etiologic agent is crucial for the definitive diagnosis ... | 2011 | 21629720 |
| microbial etiology of febrile neutropenia. | bacterial and fungal infections are a major cause of morbidity and mortality among neutropenic patients. the choice of empiric antimicrobial regimen is based on susceptibility pattern of locally prevalent pathogens. from 64 febrile neutropenic patients with clinical sepsis, blood and other appropriate clinical specimens were processed to determine bacterial and fungal spectrum and their antimicrobial susceptibility pattern. risk factors for developing sepsis were determined by case-control study ... | 2010 | 21629636 |
| molecular analysis of ndm-1-producing enterobacterial isolates from geneva, switzerland. | objectives to analyse the mechanisms responsible for decreased susceptibility or resistance to carbapenems in several enterobacterial isolates recovered in 2009-10 in geneva university hospitals, switzerland. methods pcr and sequencing were used to identify β-lactamases, 16s rna methylases and plasmid-mediated quinolone resistance genes. the transferable properties of the plasmids were analysed, as well as their plasmid type. the strains were typed by multilocus sequence typing. results three pa ... | 2011 | 21628303 |
| new delhi metallo-ss-lactamase-1: local acquisition in ontario, canada, and challenges in detection. | new delhi metallo-ß-lactamase-1 (ndm-1) is a recently identified metallo-ß-lactamase that confers resistance to carbapenems and all other ß-lactam antibiotics, with the exception of aztreonam. ndm-1 is also associated with resistance to many other classes of antibiotics. the enzyme was first identified in organisms isolated from a patient in sweden who had previously received medical treatment in india, but it is now recognized as endemic throughout india and pakistan and has spread worldwide. t ... | 2011 | 21624908 |
| do mobile phones of patients, companions and visitors carry multidrug-resistant hospital pathogens? | a cross-sectional study was conducted to determine bacterial colonization on the mobile phones (mps) used by patients, patients' companions, visitors, and health care workers (hcws). significantly higher rates of pathogens (39.6% vs 20.6%, respectively; p = .02) were found in mps of patients' (n = 48) versus the hcws' (n = 12). there were also more multidrug pathogens in the patents' mps including methicillin-resistant staphylococcus aureus, extended-spectrum β-lactamase-producing escherichia co ... | 2011 | 21624635 |
| [analysis of antibiotic resistance and genotypes on extended spectrum β-lactamase and ampc β-lactamase producing strains isolated from uygur and han newborns.] | objective: this study aimed to investigate drug resistance and genotypes of the extended spectrum β-lactamase (esbls) and ampc β-lactamase-producing escherichia coli and klebsiella pneumoniae isolated from uygur and han newborns in urumqi. methods: disk diffusion test (kirby-bauer) was used for detecting drug resistance of 299 strains to twenty two kinds of antibiotics. resistance genes of the esbls and ampc β-lactamase-producing strains were amplified by multiplex pcr and subtypes were confirme ... | 2011 | 21624232 |
| [comparative studies on the composition and antibiotic-resistance of pathogenic bacteria between children with community-acquired and hospital-acquired pneumonia.] | objective: this research was to explore the difference between children with community-acquired pneumonia (cap) and hospital-acquired pneumonia (hap) in the composition and antibiotic-resistance of pathogenic bacteria. methods: 241 cap and 116 hap with positive sputum culture who were hospitalized from january to december in 2008 in children's hospital affiliated to suzhou university were selected in this study. the bacteria were identified by traditionally manual method and antibiotic sensitivi ... | 2011 | 21624231 |
| engineering klebsiella sp. 601 multicopper oxidase enhances the catalytic efficiency towards phenolic substrates. | abstract: background: structural comparison between bacterial cueo and fungal laccases has suggested that a charged residue glu (e106) in cueo replaces the corresponding residue phe in fungal laccases at the gate of the tunnel connecting type ii copper to the protein surface and an extra alpha-helix (l351-g378) near the type i copper site covers the substrate binding pocket and might compromise the electron transfer from substrate to type i copper. to test this hypothesis, several mutants were m ... | 2011 | 21624144 |
| clinical review of endogenous endophthalmitis in korea: a 14-year review of culture positive cases of two large hospitals. | purpose: to identify the clinical features and outcomes of endogenous endophthalmitis in korea. materials and methods: we reviewed 18 patients with endogenous endophthalmitis at 2 korean hospitals, treated over a 14 year period between january 1993 and december 2006. results: the comorbidities observed in these cases were diabetes mellitus and liver cirrhosis. the most common pathogens, which were found in 7 patients each (38.9%), were klebsiella pneumonia and pseudomonas aeruginosa. all patient ... | 2011 | 21623606 |
| phytochemical analysis and antimicrobial activities of methanolic extracts of leaf, stem and root from different varieties of labisa pumila benth. | a local herb, kacip fatimah, is famous amongst malay women for its uses in parturition; however, its phytochemical contents have not been fully documented. therefore, a study was performed to evaluate the phenolics, flavonoids, and total saponin contents, and antibacterial and antifungal properties of the leaf, stem and root of three varieties of labisia pumila benth. total saponins were found to be higher in the leaves of all three varieties, compared to the roots and stems. leaves of var. pumi ... | 2011 | 21623314 |
| [gastric wall abscess.] | no abstract available. | 2011 | 21623144 |
| [a case of acute phlegmonous gastritis causing gastroparesis and cured with medical treatment alone.] | acute phlegmonous gastritis is an uncommon disease, often fatal condition characterized by suppurative bacterial infection of the gastric wall. it has a high mortality rate mainly because the diagnosis is usually made late. until recently, gastrectomy in combination with antibiotics was recommended. we had experienced a case of 66-year-old man presented with epigastric pain, nausea, vomiting, and hematemesis, followed by aspiration pneumonia. at upper gastrointestinal endoscopy, the gastric lume ... | 2011 | 21623140 |
| infection control practices need ingenuous processes beyond prescribed guidelines. | 2011 | 21623118 | |
| profile of bacterial pneumonia during hajj. | background & objectives : the congregation of a large number of people during hajj seasons from different parts of the world in overcrowded conditions within a confined area for a long period of time presents many public health challenges and health risks. one of the main health problems of the crowding is ease transmission of pneumonia by air droplets. this study was aimed to determine the most common causes of bacterial pneumonia during the 2005 hajj season and to relate the findings with clin ... | 2011 | 21623036 |
| complete (1)h and (13)c nmr chemical shift assignments of mono-, di-, and trisaccharides as basis for nmr chemical shift predictions of polysaccharides using the computer program casper. | the computer program casper uses (1)h and (13)c nmr chemical shift data of mono- to trisaccharides for the prediction of chemical shifts of oligo- and polysaccharides. in order to improve the quality of these predictions the (1)h and (13)c, as well as (31)p when applicable, nmr chemical shifts of 30 mono-, di-, and trisaccharides were assigned. the reducing sugars gave two distinct sets of nmr resonances due to the α- and β-anomeric forms. in total 35 (1)h and (13)c nmr chemical shift data sets ... | 2011 | 21621752 |
| perfusion fluid contamination in relation to recipient survival and acute cellular rejection in orthotopic liver transplantation: retrospective analysis. | a perfusion fluid used in the preservation of a grafted liver represents a medium suitable for microorganism growth. this study investigated the prevalence of perfusion fluid contamination, acute cellular rejection (acr) episodes, and patient survival rate. | 2011 | 21620118 |
| airway pathogens during the first year after lung transplantation: a single-center experience. | after lung transplantation, a high level of immunosuppression is needed to prevent rejection. this demand renders recipients more sensitive to infections. as pulmonary infections are a major clinical problem during the first postoperative year after lung transplantation, preventive treatment and regular surveillance examinations are needed for immediate, adequate therapy. we describe the airway pathogens registered during the first posttransplantation year among our 12 lung transplant recipients ... | 2011 | 21620113 |
| antimicrobial resistance status and prevalence rates of extended spectrum beta-lactamase (esbl) producers isolated from a mixed human population. | owing to the increasing epidemiological and therapeutic challenges associated with infections due to esbl producers, esbl prevalence rate among some bacteria isolates from healthy and non-healthy human population in a metropolitan nigerian setting was evaluated. a total of one hundred and forty-five (145) bacteria strains were isolated from a total of four hundred and sixty (460) samples collected from urine, wound, throat and anal swabs of 220 healthy volunteers in the community and from 240 pa ... | 2011 | 21619555 |
| comparative activity of tigecycline and tetracycline on gram-negative and gram-positive bacteria revealed by a multicentre study in four north european countries. | abstract background: this study involves a multicentre surveillance of tigecycline and tetracycline activity against gram-negative and gram-positive bacteria from primary care centres (pccs), general hospital wards (ghws) and intensive care units (icus) in denmark (n = 9), finland (n = 10), norway (n = 7) and sweden (n = 19). methods: the hospitals were each asked to test 30 consecutive gram-positive and 30 gram-negative clinical isolates. supportive information accompanying each isolate include ... | 2011 | 21619494 |
| potentiation of antimicrobial activity of ciprofloxacin by pelargonium graveolens essential oil against selected uropathogens. | the recent approach of using herbs and antibiotics in combination constitutes a strategy to overcome the problems of resistance and side effects associated with conventional antibiotics. in the present study, the antimicrobial effect of pelargonium graveolens l' hér essential oil in combination with ciprofloxacin was evaluated on uropathogens, namely, klebsiella pneumoniae kt2, proteus mirabilis prt3 and staphylococcus aureus st2. minimum inhibitory concentrations of p. graveolens essential oil ... | 2011 | 21618302 |
| etiology of septicemia in children with acute leukemia: 9-year experience from a children's hospital in china. | bloodstream infection is an important cause of death among leukemia patients, and the etiologic agent surveillance is important for the prophylaxis and treatment. this study aims to identify the common bloodstream isolates in hospitalized leukemia patients with septicemia in our hospital, to choose the ideal combination of antimicrobial agents for infection prophylaxis and to clarify the appropriate time for antibiotic prophylaxis. to know this information, a retrospective analysis was conducted ... | 2011 | 21617561 |
| the newly discovered clpk protein strongly promotes survival of k. pneumoniae biofilm subjected to heat shock. | not applicable. | 2011 | 21617023 |
| prognostic factors and outcomes in endogenous klebsiella endophthalmitis. | 2011 | 21616217 | |
| bio-generated metal binding polysaccharides as catalysts for synthetic applications and organic pollutant transformations. | iron and palladium binding an exopolysaccharide (eps) were obtained and purified from cultures of bacterial cells of klebsiella oxytoca bas-10. the strain bas-10 was able to grow under anaerobic conditions with fe(iii)-citrate as energy and carbon source, producing fe(iii)-eps that was extracted and used as catalyst in the oxidation reaction of phenol with h(2)o(2). the same bacterial strain was cultivated anaerobically with na-citrate and pd(2)(no)(3) was added during the exponential growth to ... | 2011 | 21616180 |
| characterization of the structure and function of klebsiella pneumoniae allantoin racemase. | the oxidative catabolism of uric acid produces 5-hydroxyisourate (hiu), which is further degraded to (s)-allantoin by two enzymes, hiu hydrolase and 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. the intermediates of the latter two reactions, hiu and 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline, are unstable in solution and decay nonstereospecifically to allantoin. in addition, nonenzymatic racemization of allantoin has been shown to occur at physiological ph. since the further br ... | 2011 | 21616082 |
| antiphospholipid syndrome in a neonate. | antiphospholipid syndrome presenting in the neonatal period is very rare. although antiphospholipid antibodies from mothers with antiphospholipid syndrome can cross the placenta and put their neonates at risk, the occurrence of thrombotic complications in these neonates is uncommon. we present a 10-day-old neonate who developed klebsiella sepsis with arterial gangrene of the left lower limb. investigations revealed thrombosis of the left femoral artery with both the mother and the neonate positi ... | 2011 | 21615477 |
| antimicrobial activity of protease inhibitor from leaves of coccinia grandis (l.) voigt. | antimicrobial activity of protease inhibitor isolated from coccinia grandis (l.) voigt. has been reported. a 14.3 kda protease inhibitor (pi) was isolated and purified to homogeneity by ammonium sulfate precipitation (20-85% saturation), sephadex g-75, deae sepharose column and trypsin-sepharose affinity chromatography from the leaves of c. grandis. the purity was checked by reverse phase high performance liquid chromatography. pi exhibited marked growth inhibitory effects on colon cell lines in ... | 2011 | 21615062 |
| essential oil composition and antibacteral activity of vismia baccifera fruits collected from mérida, venezuela. | the essential oil from the fruits of vismia baccifera triana & planch. (gutttiferae), collected in june 2009, was analyzed by gc/ms. a yield of 0.6% oil was obtained by hydrodistillation. twenty-seven components were identified by comparison of their mass spectra with those in the wiley gc-ms library data base. the major components were trans-cadin-l1,4-diene (36.6%), cis-cadin-1,4-diene (18.8%) and beta-caryophyllene (11.9%). the essential oil showed a broad spectrum of antibacterial activity a ... | 2011 | 21615035 |
| natural resistance of rose petals to microbial attack. | petals of red, yellow and white roses (rosa damascene mill.) of the family rosaceae were extracted with (1:1) methylene chloride/methanol and tested for their antimicrobial activities against four species of gram-positive bacteria (bacillus cereus, bacillus subtilis, micrococcus luteus and staphylococcus aureus), five species of gram-negative bacteria (enterobacter aerogenes, escherichia coli, klebsiella pneumonia, pseudomonas aeruginosa and serratia marcescens) and five species of fungi (penici ... | 2011 | 21614712 |
| emergence of extended-spectrum β-lactamase (esbl)-producing klebsiella pneumoniae in danish hospitals; this is in part explained by spread of two ctx-m-15 clones with multilocus sequence types 15 and 16 in zealand. | 2011 | 21612893 | |
| prevalence and genetic characteristics of tem, shv, and ctx-m in clinical klebsiella pneumoniae isolates from saudi arabia. | the prevalence and genetic basis of extended-spectrum beta-lactamases (esbls) in klebsiella pneumoniae remains unclear in saudi arabia. therefore, this study was devoted to determine the prevalence and characterize esbl-producing k. pneumoniae in al-qassim area, saudi arabia. a total of 430 isolates of k. pneumoniae isolated from clinical samples were collected over 6 months from january to june 2008. these isolates were screened for the presence of esbls by double-disk synergy test and re-evalu ... | 2011 | 21612509 |
| synergistic effects and physiological responses of selected bacterial isolates from animal feed to four natural antimicrobials and two antibiotics. | abstract in this study, 20 samples from three different sources of animal feed were investigated and six bacterial isolates were identified. the susceptibility of four natural antimicrobials, namely, eugenol, cinnamaldehyde, thymol, and carvacrol, against six of these isolates was determined. carvacrol and eugenol showed better inhibitory effects with larger zones of inhibition. the minimal inhibitory concentration for a range of antibiotics on the susceptibility of two isolates (namely, sphingo ... | 2011 | 21612425 |
| [validity of using imipenem as a representative carbapenems and levofloxacin as a representative fluoroquinolones in antibiotics susceptibility test for enterobacteriaceae]. | in antimicrobial susceptibility test for enterobacteriaceae, the efficacies of carpapenems are predicted by the minimum inhibitory concentration (mic) of imipenem, and that of fluoroquinolones are predicted by the mic of levofloxacin. to assess its judgement, we compared the mics of imipenem, meropenem, panipenem, and doripenem for carbapenems, and ciprofloxacin, levofloxacin, tosufloxacin and pazufloxacin for fluoroquinolones of clinically isolated enterobacteria, escherichia coli, klebsiella p ... | 2011 | 21612040 |
| f-fdg pet/ct as a potential valuable adjunct to mri in characterising the brodie's abscess. | chronic osteomyelitis (brodie's abscess) is essentially a problem of diagnosis, and there may be considerable difficulty in distinguishing it from other benign and malignant bone lesions. early diagnosis of brodie's abscess is deemed important as the disease has a good curative potential following an appropriate antibiotic treatment. of late, pet/ct using (18)f-fdg is taking a centre stage in the imaging of bone infection though documentation on its role in characterising the feature of brodie's ... | 2010 | 21611044 |
| high prevalence of ctx-m-15-producing klebsiella pneumoniae isolates in asian countries: diverse clones and clonal dissemination. | the characteristics of 218 klebsiella pneumoniae isolates from patients with hospital-acquired pneumonia in nine asian countries were investigated. in total, 92 isolates (42.2%) produced extended-spectrum β-lactamases (esbls), amongst which 67 (72.8%) possessed ctx-m esbl genes; ctx-m-15 was the major esbl (55 isolates; 59.8%). multilocus sequence typing (mlst) and plasmid replicon typing were performed to investigate the genetic backgrounds of the 55 ctx-m-15-producing k. pneumoniae isolates. t ... | 2011 | 21605960 |
| sources other than unused sawdust can introduce klebsiella pneumoniae into dairy herds. | a longitudinal study was carried out to detect intramammary infections caused by klebsiella pneumoniae and to identify potential sources of this bacterial species in the environment of the cows. the study was performed in 6 well-managed belgian dairy herds from may 2008 to may 2009. monthly (n=13), unused and used sawdust bedding samples as well as individual quarter milk and feces samples were collected from 10 randomly selected cohort cows in each herd. cases of clinical mastitis of all lactat ... | 2011 | 21605753 |
| bacteriological differences between patients with acute exacerbation of copd and community-acquired pneumonia. | objective: to study the differences in pathogen distribution and antimicrobial drug susceptibility between patients with acute exacerbation chronic obstructive pulmonary disease (copd exacerbation) and community-acquired pneumonia (cap), thereby providing guidance for the antibiotic treatment of such diseases. methods: a retrospective analysis of the medical records from our patients with copd exacerbation and cap from january 2007 to december 2008 was conducted, where 586 copd exacerbation pati ... | 2011 | 21605476 |
| surgical approach to extensive hidradenitis suppurativa. | background hidradenitis suppurativa (hs) is a chronic suppurative disease of skin with high recurrence. objective to determine factors affecting complications and recurrence of hs in patients who underwent surgery. materials and methods we operated on 15 patients with hs at 36 sites between 1999 and 2009. the affected areas were classified as groin, axilla, buttocks, nuchae, perianal, and perineal. all patients were treated using wide surgical excision under general anesthesia. the methods of re ... | 2011 | 21605246 |
| simultaneous detection of methicillin-resistant staphylococcus aureus, acinetobacter baumannii, escherichia coli, klebsiella pneumoniae and pseudomonas aeruginosa by multiplex pcr. | a pcr-based assay that can simultaneously detect and differentiate five different types of nosocomial bacterial pathogens was developed. six pairs of selected primers targeting fema (132 bp) and meca (310 bp) of methicillin-resistant staphylococcus aureus, glta (722 bp) of acinetobacter baumannii, phoa (903 bp) of escherichia coli, mdh (364 bp) of klebsiella pneumoniae and oprl (504 bp) of pseudomonas aeruginosa were used in this study. the conditions were optimized for the multiplex pcr to ensu ... | 2011 | 21602765 |
| broad spectrum biofilm inhibition by kingella kingae exopolysaccharide. | cell-free extracts prepared from kingella kingae colony biofilms were found to inhibit biofilm formation by aggregatibacter actinomycetemcomitans, klebsiella pneumoniae, staphylococcus aureus, s. epidermidis, candida albicans and k. kingae. the extracts evidently inhibited biofilm formation by modifying the physicochemical properties of the cell surface, the biofilm matrix, and the substrate. chemical and biochemical analyses indicated that the biofilm inhibition activity in the k. kingae extrac ... | 2011 | 21602333 |
| effect of culture conditions on producing and uptake hydrogen flux of biohydrogen fermentation by metabolic flux analysis method. | in this work, metabolic flux analysis (mfa) method was used to estimate the effects of the culture conditions on both the producing and uptake hydrogen flux inside the cell of klebsiella pneumoniae ecu-15. the results indicated that higher temperature could reduce the amount of the uptake hydrogen and enhance the hydrogen production from the nadh pathway. moreover, both the producing hydrogen flux from formate and the uptake hydrogen flux were attained to the maximum at ph 7.0-7.5. the producing ... | 2011 | 21602042 |
| [the clinical efficacy and safety of intravenous cefmetazole in treatment of 1522 patients with aspiration pneumonia.] | objective: to evaluate the efficacy and safety of intravenous cefmetazole in the treatment of patients with aspiratory pneumonia. methods: a multicenter, prospective and open-labeled trial was conducted. a total of 1522 patients were enrolled at the beginning, and only 1324 were evaluabled at the endpoint. the duration of treatment was 7 - 14 days. during the treatment and follow-up periods, we recorded any unexpected symptoms and abnormal laboratory tests. at last, we evaluated its efficacy and ... | 2011 | 21600147 |
| comparisons of resistance of cf and non-cf pathogens to hydrogen peroxide and hypochlorous acid oxidants in vitro. | abstract: background: cystic fibrosis (cf) lung disease has a unique profile of pathogens predominated by pseudomonas aeruginosa (psa) and staphylococcus aureus (sa). these microorganisms must overcome host immune defense to colonize the cf lungs. polymorphonuclear neutrophils are a major component of the host defense against bacterial infection. a crucial microbicidal mechanism is the production of oxidants including hydrogen peroxide (h2o2) and hypochlorous acid (hocl) by neutrophils to achiev ... | 2011 | 21599970 |
| in vitro antimicrobial activity of ten medicinal plants against clinical isolates of oral cancer cases. | abstract: background: suppression of immune system in treated cancer patients may lead to secondary infections that obviate the need of antibiotics. in the present study, an attempt was made to understand the occurrence of secondary infections in immuno-suppressed patients along with herbal control of these infections with the following objectives to: (a) isolate the microbial species from the treated oral cancer patients along with the estimation of absolute neutrophile counts of patients. (b) ... | 2011 | 21599889 |
| cross-linking of dimeric cits and glts transport proteins. | abstract cits of klebsiella pneumoniae and glts of escherichia coli are na(+)-dependent secondary transporters from different families that are believed to share the same fold and quaternary structure. a 10 kda protein tag (biotin acceptor domain [bad]) was fused to the n-terminus of both proteins (cits-bad1 and glts-bad1, respectively) and inserted in the central cytoplasmic loop that connects the two halves of the proteins (cits-bad260 and glts-bad206). both cits constructs and glts-bad206 wer ... | 2011 | 21599460 |
| postfragmentation density function for bacterial aggregates in laminar flow. | the postfragmentation probability density of daughter flocs is one of the least well-understood aspects of modeling flocculation. we use three-dimensional positional data of klebsiella pneumoniae bacterial flocs in suspension and the knowledge of hydrodynamic properties of a laminar flow field to construct a probability density function of floc volumes after a fragmentation event. we provide computational results which predict that the primary fragmentation mechanism for large flocs is erosion. ... | 2011 | 21599205 |
| [beta-lactamases of clinical isolates of enterobacteriaceae family]. | among 62 clinical strains of enterobacteria, isolated from intestinal tract, representatives of genus escherichia made--67.4%, klebsiella--4.84%, citrobacter--4.84%, enterobacter--8.06%, proteus--6.45%, morganella of 8.06%. preparations of fluorquinolone group--gatifloxacin and moxifloxacin, the number of steady strains being from 0.0% to 33.3%, were the most effective in respect of enterobacteria the investigated strains of enterobacteria showed considerable resistance to beta-lactam antibiotic ... | 2011 | 21598655 |