Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| arterialisation of transcutaneous oxygen and carbon dioxide. | we compared previously calculated global correction factors for oxygen and carbon dioxide arterial/transcutaneous ratios with individual in vivo calibrations from the first arterial sample. in infants beyond the neonatal period and older children in vivo calibration confers little benefit over the use of a global calibration correction factor for transcutaneous carbon dioxide, and may reduce the precision with which arterial oxygen can be estimated from transcutaneous oxygen. | 2011 | 3144247 |
| problems assessed but far from resolved in 1988. | 2011 | 3143657 | |
| altered images. | 2011 | 3143092 | |
| guidelines for the use of vitamins, trace elements, calcium, magnesium, and phosphorus in infants and children receiving total parenteral nutrition: report of the subcommittee on pediatric parenteral nutrient requirements from the committee on clinical practice issues of the american society for clinical nutrition. | 2011 | 3142247 | |
| [structural and ultrastructural study of the kidney of the tench, tinca tinca l., after experimental poisoning by the absorption of lead nitrate]. | 2011 | 3142178 | |
| alcohol-related birth defects: an update. | historically, mankind has at least suspected that alcohol was somehow connected with undesirable effects on progeny. in the 18th century, physicians became aware that maternal alcohol consumption resulted in excess fetal and neonatal mortality, low birth weight, and many other deleterious effects. perhaps as a response to the temperance and prohibition periods, scientists lost sight of or interest in the effects of alcohol in pregnancy. in the late 1960s and early 1970s, the issue surfaced again ... | 2011 | 3141958 |
| expression of four virulence antigens of shigella flexneri is positively regulated at the transcriptional level by the 30 kilodalton virf protein. | on the virulence plasmid of shigella flexneri the virg region required for cell-to-cell spread of the bacterium encodes a 130 kilodalton (kd) antigen and region-2 essential for the bacterial invasion of epithelial cells encodes 57, 43 and 39 kd antigens. the expression of these four antigens is positively regulated by the 30 kd protein encoded by virf, whose nucleotide sequence had been determined and which was previously found to be essential for virulence. an approximately 3.8 kilobase (kb) rn ... | 1988 | 3141742 |
| asnr presidential address, 1988. | 2011 | 3140646 | |
| [dysenteric arthritis--a case-related observation]. | 1988 | 3140351 | |
| monitoring during sedation for endoscopy. | 2011 | 3139209 | |
| processing of neurofilament proteins from perikaryal to axonal type. | in previous studies, neuronal cell bodies, excised by hand from bovine spinal ganglia, were analyzed and heterogeneous intermediate and high molecular weight neurofilament proteins that differed in electrophoretic mobility from their axonal counterparts were demonstrated. in the present experiment, intermediate and high molecular weight neurofilament proteins of the axonal type were treated with alkaline phosphatase, and neurofilament proteins enriched in perikaryal type proteins were labeled wi ... | 1988 | 3137483 |
| hcfa will test a new hmo payment system. | 2010 | 3137146 | |
| the unique nutritional needs of the elderly patient with cancer. | 2011 | 3136525 | |
| segregation analysis of juvenile myoclonic epilepsy. | we examined the inheritance of juvenile myoclonic epilepsy (jme). we looked at both the trait of "epilepsy" and the trait of "epilepsy-plus-eeg abnormalities," since eeg abnormalities are frequently found in the clinically unaffected sibs of jme patients. we tested several modes of inheritance including the fully penetrant recessive and several two-locus models. we could reject all models tested (fully penetrant single-locus and two-locus models) when abnormal eegs were classified as "unaffected ... | 2010 | 3136050 |
| peliosis hepatis in a patient with marasmus. | peliosis hepatitis is a rare disorder previously seen in tuberculosis and malignant disorders and now seen with anabolic steroid use or after renal transplantation. we report the first case of peliosis hepatis in a patient with marasmus and no previously reported predisposing condition. of interest, the peliosis hepatis resolved rapidly (over 2-3 wk) as determined by computed tomography scan and the patient presented with a cholestatic enzyme pattern that resolved with development of the lesion. | 2011 | 3135227 |
| [progress in health services research. diagnostic related groups]. | 2011 | 3133820 | |
| industry weighs merits of long-term care bills. | 2011 | 3133303 | |
| esophageal leiomyoma arising in an epiphrenic diverticulum. | a 32-year old woman was found at surgery to have an esophageal leiomyoma arising within an epiphrenic diverticulum. these uncommon conditions may rarely occur together, causing difficulty in diagnosis of the leiomyoma. other neoplasms may also arise in an epiphrenic diverticulum and should be borne in mind in this situation. | 2011 | 3133209 |
| departmental divisions and the crisis in undergraduate medical education. | 2011 | 3133048 | |
| death despite malaria prophylaxis. | 1988 | 3133035 | |
| [this is how parents can feel--donna is coming home with us! wait, you can't just do that!]. | 2011 | 3131909 | |
| [histamine liberation inhibitors]. | 2011 | 3131688 | |
| valproate-associated hepatotoxicity and its biochemical mechanisms. | intake of the anticonvulsant drug valproic acid, or its sodium salt, has been associated with occasional instances of severe and sometimes fatal hepatotoxicity. probably at least 80 cases have occurred worldwide. the syndrome affects perhaps 1 in 10,000 persons taking the drug, and usually develops in the early weeks or months of therapy. most instances have involved children, usually those receiving more than 1 anticonvulsant. multiple cases have occurred in 2 families. the typical presentation ... | 2011 | 3131628 |
| records involving riders of powered two-wheeled vehicles. | 2011 | 3131520 | |
| high progesterone/estradiol ratio in follicular fluid at oocyte aspiration for in vitro fertilization as a predictor of possible pregnancy. | eighteen women undergoing in vitro fertilization (ivf) procedures were studied. all had optimal (900 to 1600 pg/ml) peak serum estradiol (e2) response to the same stimulation regimen with clomiphene citrate and menotropins; fertilization rate was above 64%; and two to four embryos in two to eight cell stages were replaced in each patient. all were considered to have optimal chances for conception. the authors compared progesterone (p), e2, and p/e2 ratio in serum and follicular fluid (ff) at the ... | 2011 | 3131157 |
| effects of growth hormone-releasing hormone and corticotropin-releasing hormone on the release of thyrotropin-releasing hormone from the rat hypothalamus in vitro. | effects of growth hormone-releasing hormone (grh) and corticotropin-releasing hormone (crh) on the release of immunoreactive thyrotropin-releasing hormone (ir-trh) from the rat hypothalamus in vitro were studied. the rat hypothalamus was incubated in medium 199 with 1.0 mg/ml of bacitracin (ph 7.4) for 20 min. the amount of ir-trh release into the medium was measured by radioimmunoassay. the ir-trh release from the rat hypothalamus was inhibited significantly in a dose-related manner with the ad ... | 1987 | 3131150 |
| lectin-like components in the macronuclear replication bands of euplotes eurystomus. | upon incubation with fluoresceinylated neoglycoproteins, isolated macronuclei from the ciliated protozoan euplotes eurystomus display different labelling patterns depending on the nature of the sugar bound to the neoglycoproteins. specific sugar-binding components (i.e., lectin-like molecules) are associated with presumed nucleoli and with the macronuclear replication bands. this is the first demonstration that dna synthesis and sugar-binding components are co-localized in an eukaryotic cell. | 2010 | 3130115 |
| lectin-like components in the macronuclear replication bands of euplotes eurystomus. | upon incubation with fluoresceinylated neoglycoproteins, isolated macronuclei from the ciliated protozoan euplotes eurystomus display different labelling patterns depending on the nature of the sugar bound to the neoglycoproteins. specific sugar-binding components (i.e., lectin-like molecules) are associated with presumed nucleoli and with the macronuclear replication bands. this is the first demonstration that dna synthesis and sugar-binding components are co-localized in an eukaryotic cell. | 2010 | 3130115 |
| inhibition of beta-bungarotoxin binding to brain membranes by mast cell degranulating peptide, toxin i, and ethylene glycol bis (beta-aminoethyl ether)-n,n,n',n'-tetraacetic acid. | the presynaptically active snake venom neurotoxin beta-bungarotoxin (beta-butx) is known to affect neurotransmitter release by binding to a subtype of voltage-activated k+ channels. here we show that mast cell degranulating (mcd) peptide from bee venom inhibits the binding of 125i-labeled beta-butx to chick and rat brain membranes with apparent ki values of 180 nm and 1100 nm, respectively. the mechanism of inhibition by mcd peptide is noncompetitive, as is inhibition of 125i-beta-butx binding b ... | 1988 | 3130091 |
| reappearance of embryonic neutral alpha-glucosidase isoenzyme in acid maltase-deficient muscle of japanese quail. | two neutral alpha-glucosidase isoenzymes were isolated from the muscle of japanese quails with late-onset acid maltase deficiency. one isoenzyme is predominantly expressed in embryonic muscle and the other in adult muscle. the time of switching from one to the other of these two neutral alpha-glucosidases was the same as in normal birds. the glycogen content in acid maltase-deficient muscle was not inversely proportional to the amount of embryonic neutral alpha-glucosidase. from the results, we ... | 2011 | 3129300 |
| induction of indoleamine dioxygenase by interferon in mice: a study with different recombinant interferons and various cytokines. | since it is important the availability of a specific marker for interferon induction in vivo, we investigated the effect of different recombinant interferons and various cytokines on indoleamine 2,3-dioxygenase activity. although with different magnitude, recombinant interferon-alpha a/d (bgl ii) hybrid, interferon-gamma and tumor necrosis factor, all increase the activity of this enzyme, whereas interleukin-1, recombinant interferon-alpha a and interferon-alpha d do not induce this activity in ... | 2011 | 3128977 |
| application of a decision-making model for resolving ethical problems. | 2011 | 3128937 | |
| feline aortic thromboemboli. | 1988 | 3128904 | |
| antinuclear antibody-negative systemic lupus erythematosus (sle) and severe renal involvement: close correlation between disease activity and appearance of circulating anticoagulant. | a 16-year-old girl meeting the criteria for sle is described. salient features of the clinical course included active glomerulonephritis with dense subepithelial deposits on electron microscopy, pulmonary embolism, axillary vein thrombosis, arthritis, serositis and fever. disease activity correlated with the presence of lupus anticoagulant as measured by vdrl and partial thromboplastin time (ptt). her serum was consistently negative to ana, anti-ds-dna, anti-ss-dna, ena, anti-ro, anti-la, and le ... | 2007 | 3128493 |
| electron backscatter corrections for parallel-plate chambers. | the wall of an ionization chamber is commonly assumed to have a negligible effect on chamber response in electron beams. for cylindrical chambers with thin walls this assumption is valid. however, parallel-plate chambers commonly possess large mechanical supports which may affect chamber response in a manner not accounted for in current dosimetry protocols. this is due to changes with energy in the relative backscattered electron fluence between chamber support and phantom materials. to investig ... | 2011 | 3127670 |
| preliminary report of haemoproteus tinnunculi infection in a breeding population of american kestrels (falco sparverius). | a population of american kestrels breeding in southeastern pennsylvania was examined for hematozoa. haemoproteus tinnunculi infected 17 of 23 (74%) of the adults. parasitemia ranged from two to 252, with a median of 32 infected erythrocytes per 10,000. parasitemia and body weight of female kestrels were negatively correlated. this parasite was not observed in the six juvenile or 38 nestling kestrels examined. trypanosoma sp. was detected by culture in three of seven (43%) adults, but not in the ... | 2011 | 3127602 |
| estimation of pyruvate dehydrogenase (e1) activity in human skeletal muscle; three cases with e1 deficiency. | pyruvate dehydrogenase (e1) catalyzes the rate-limiting step of the pyruvate dehydrogenase complex. since e1 activity of human muscle tissue is low, a sensitive method is needed for diagnostic purposes. measurement of 14co2 production from [1-14c]pyruvate provides a specific and sensitive assay for measuring e1 activity. we use as artificial electron acceptor dichlorophenolindophenol (dcpip) instead of the often applied ferricyanide. the method can be applied to small muscle samples obtained by ... | 1988 | 3127087 |
| factors influencing the accumulation of sediment-sorbed hexachlorobiphenyl by midge larvae. | 2011 | 3125867 | |
| effects of cadmium on human platelet reactions. | human platelets incubated with cd2+ took up the cation slowly, and the uptake was speeded up by ionophore a23187. the capacity of human platelets to accumulate cd2+ was large, equivalent to 10 nmol cd2+ per mg protein. the effects of cd2+ on protein phosphorylation and serotonin release of human platelets were studied. washed platelets incubated with cd2+ showed a general increase in protein phosphorylation concurrent with a slow release of serotonin. in the presence of ionophore a23187, however ... | 1987 | 3125819 |
| clinical predictors of arrhythmia worsening by antiarrhythmic drugs. | aggravation of ventricular arrhythmia is a serious, potentially lethal, side effect that can occur with all antiarrhythmic agents. the purpose of this retrospective case-controlled study was to identify clinically useful parameters that would predict aggravation of arrhythmia. patients in whom arrhythmia worsened while taking either quinidine, mexiletine or encainide were selected and matched to 2 similar patients who never developed this drug complication with any antiarrhythmic tested. a numbe ... | 2011 | 3124591 |
| polymicrobial septicemia due to shigella flexneri and pseudomonas aeruginosa: first report. | an invasion of the bloodstream by members of the genus shigella is extremely rare. when it does occur, the etiologic agent is usually a single organism. a report of the first case of shigella bacteremia that was complicated by pseudomonas aeruginosa sepsis is reported. | 1987 | 3123706 |
| future developments in the food industry. | 2011 | 3123680 | |
| telomeric dna-protein interactions of oxytricha macronuclear dna. | telomeres of oxytricha macronuclear chromatin exist as discrete nonnucleosomal dna-protein complexes, each of which encompasses the terminal 100-150 bp of a macronuclear dna molecule. we have used chemical and nuclease footprinting to examine the internal structure of these telomeric complexes. remarkably salt-stable dna-protein interactions result in methylation-protection of specific guanine residues in the 3'-terminal t4g4t4g4 tail. the methylation pattern seen in vivo and in isolated macronu ... | 2011 | 3123321 |
| interleukin-2 receptor levels are increased in blood of heart transplant patients during infections. | increased levels of soluble interleukin-2 (il-2) receptor were found in plasma of six patients after the heart transplantation. the levels peaked the first week after transplantation and then gradually decreased to normal levels. the moderate episodes of heart transplant rejection did not affect the il-2 receptor levels in comparison to transplant recipients without the rejection episodes. however, the transplant patients with pneumonia had the il-2 receptor levels ten times higher than healthy ... | 2011 | 3123088 |
| lactate dehydrogenase and malate dehydrogenase of sertoli cells in rats. | lactate-dehydrogenase (ldh) and malate-dehydrogenase (mdh) activities and isozyme patterns of maturing sertoli cells were investigated in cultured cells obtained from 2-5-week-old rats. both enzymes, and more strikingly ldh, increased between 2 and 3 weeks of age. ldh isozyme complement included all five isozymes and, in the more mature rats, had a shift toward the isoforms rich in subunit. these data are consistent with an increasing production of lactate/pyruvate and with a finer regulation of ... | 1987 | 3122678 |
| [24-hour efficacy of a system of transcutaneous administration of nitroglycerin. evaluation by the exercise test and gamma angiography]. | the effects of a nitroglycerin transdermal therapeutic system (tts ng 10 mg/24 h) 24 hours after application were evaluated by exercise left ventricular radionuclide cineangiography. 20 patients with ischemic heart disease were included in a double-blind, within patient, acute study comparing tts ng to placebo. were measured: exercise-test parameters and global (ef) and regional (ref) ejection fractions at rest and during exercise. at maximum load, the double product rose from 18,680 +/- 4,118 w ... | 2011 | 3122628 |
| evaluation of the 11co2 positron emission tomographic method for measuring brain ph. i. ph changes measured in states of altered pco2. | the 11co2 method for measuring local brain ph with positron emission tomography (pet) has been experimentally evaluated, testing the adequacy of the kinetic model and the ability of the method to measure changes in brain ph. plasma and tissue time/activity curves measured during and following continuous inhalation of 11co2 were fit with a kinetic model that includes effects of tissue ph, blood flow, and fixation of co2 into compounds other than dissolved gas and bicarbonate ions. for each of ten ... | 1987 | 3121647 |
| sequential antibiotic therapy in acute leukemia. | 2011 | 3121466 | |
| gonadotropin regulation of tissue-type and urokinase-type plasminogen activators in rat granulosa and theca-interstitial cells during the periovulatory period. | plasminogen activators (pas) are believed to be involved in ovulation. because both tissue-type plasminogen activator (tpa) and urokinase-type plasminogen activator (upa) are secreted by cultured rat granulosa cells, we have examined the activities of these proteins in ovarian homogenates as well as granulosa and theca-interstitial (ti) cells during gonadotropin-induced ovulation. immature rats were injected with 20 iu pregnant mare serum gonadotropin (pmsg) to initiate follicle development, fol ... | 1987 | 3121412 |
| assessment of contractility changes in humans by transoesophageal echocardiography: the peak-systolic pressure end-systolic diameter relationship (pspesdrs). | the peak-systolic pressure end-systolic diameter relationship (pspesdrs) was determined in ten healthy subjects under general anaesthesia by using the radial artery pressure tracing (peak-systolic pressure) and transoesophageal 2d-and m-mode echocardiography (left ventricular diameters) without blocking of autonomic reflexes. left ventricular load was changed by injection of a single intravenous dose of 0.2 mg nitroglycerin (ntg). linear regression analysis showed a close linear relationship dur ... | 2011 | 3119748 |
| effects of cost sharing on physiological health, health practices, and worry. | in a randomized trial of the effects of medical insurance on spending and the health status of the nonaged, we previously reported that patients with limited cost sharing had approximately one-third less use of medical services, similar general self-assessed health, and worse blood pressure, functional far vision, and dental health than those with free care. of the 20 additional measures of physiological health studied here on 3,565 adults, people with cost sharing scored better on 12 measures a ... | 2011 | 3119520 |
| specific reduction of n,n-dimethylnitrosamine mutagenicity in drosophila melanogaster by dimethyl sulfoxide. | dimethyl sulfoxide (dmso) used as a solvent has been observed to complicate mutagenicity screens by interacting with tested chemicals to yield false positives or negatives. we have used dmso as a solvent in the drosophila melanogaster recessive sex-linked lethal mutation assay and find that it reduces, but does not abolish, the detectable mutagenicity of n,n-dimethylnitrosamine (dmn). its use as a solvent with procarbazine, another promutagen, shows no effect on mutagenicity in drosophila. dmso ... | 2011 | 3119334 |
| a new immunomodulating compound (as-101) with potential therapeutic application. | there has been interest in the potential of synthetic compounds to modify immune responses by imitation of cytokine action. direct administration of interleukin 2 (il-2) in conjunction with adoptive transfer of lymphokine activated killer cells has been used in the treatment of cancer, but there are toxic effects resulting from the high doses of il-2 required. we have developed a new synthetic compound, ammonium tri-chloro(dioxoethylene-o,o'-)tellurate (as-101), which has immunomodulating proper ... | 1987 | 3118216 |
| the inhibition by valproic acid of the mitochondrial oxidation of monocarboxylic and omega-hydroxymonocarboxylic acids: possible implications for the metabolism of gamma-aminobutyric acid. | the interactions of 1-5 mm valproic acid with the hepatic fatty acid oxidation are here described. valproic acid was not substrate for hepatic peroxisomal fatty acid oxidation. its activation outside the mitochondrial matrix compartment was poor when compared to that of octanoic acid, a fatty acid containing the same number of carbones. valproic acid did not inhibit the fatty acyl-coa oxidase nor the cyanide-insensitive acyl-coa oxidation. valproic acid inhibited the mitochondrial oxidations of ... | 1987 | 3117781 |
| pseudoatrophy of the brain with valproic acid monotherapy. | a patient is described who, while on valproic acid monotherapy, developed reversible shrinkage of the brain, documented by computerized tomography with associated cognitive deficit. although pseudoatrophy has been reported with steroid therapy, this is the first implication of an anticonvulsant drug in the etiology of that condition. | 2011 | 3117347 |
| investigation of a health care worker with symptomatic human immunodeficiency virus infection: an epidemiologic approach. | 1987 | 3116462 | |
| efficacy of a polyvalent protein-polysaccharide dysentery oral vaccine. | 1987 | 3115716 | |
| histological changes following transplantation of developing teeth to more advanced functional positions. | 1987 | 3113409 | |
| [biology and pathology of the heart and blood vessels. study group on cardiovascular research. vittel, 6-7 mai 1987. abstracts]. | 2011 | 3113391 | |
| recombinant human tissue-type plasminogen activator therapy in acute thromboembolic stroke. | systemic fibrinolytic therapy for acute stroke is no longer recommended because of resulting systemic fibrinolysis and the risk of intracerebral hemorrhage. human tissue-type plasminogen activator (tpa) is a native enzyme that converts plasminogen to plasmin with subsequent clot lysis. the affinity for plasminogen is increased several-fold when the substrate is bound to fibrin. at appropriate dosage, "clot-specific" thrombolysis may be achieved at the surface of the thrombus without creating sys ... | 1987 | 3112328 |
| immunological relationship among glycogen-protein complexes of different species. | glycogen-protein complexes from the muscles of celerio euphorbiae and horse as well as from the livers of frog, carp and man were isolated and used as antigens. after immunization of rabbits antisera were obtained from which fractions of immunoglobulins were isolated. antibodies were used in agar immunodiffusion tests and in quantitative reaction of immunoprecipitation with glycogens. the immunoprecipitation test proved the occurrence of quantitative differences in cross reaction of complexes wi ... | 1986 | 3109350 |
| studies on the rate-determining factor in testosterone hydroxylation by rat liver microsomal cytochrome p-450: evidence against cytochrome p-450 isozyme:isozyme interactions. | the aim of the present study was to examine a recent proposal that inhibitory isozyme:isozyme interactions explain why membrane-bound isozymes of rat liver microsomal cytochrome p-450 exert only a fraction of the catalytic activity they express when purified and reconstituted with saturating amounts of nadph-cytochrome p-450 reductase and optimal amounts of dilauroylphosphatidylcholine. the different pathways of testosterone hydroxylation catalyzed by cytochromes p-450a (7 alpha-hydroxylation), ... | 1987 | 3109324 |
| purification and characterization of dihydrofolate reductase from soybean seedlings. | dihydrofolate reductase (dhfr; ec 1.5.1.3) was purified to homogeneity from soybean seedlings by affinity chromatography on methotrexate-aminohexyl sepharose, gel filtration on ultrogel aca-54, and blue sepharose chromatography. sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the enzyme gave a single protein band corresponding to a molecular weight of 22,000. the enzyme is not a 140,000 da heteropolymer as reported by others. amino acid sequence-specific antibodies to intact human d ... | 1987 | 3109322 |
| effects in rats of dietary protein inadequacy on lactose production, milk volume and components of the lactose synthetase complex (ec 2.4.1.22). | lactose synthetase (ls) is a complex of alpha-lactalbumin and n-acetylglucosamine galactosyl transferase (gt). ls is the rate-limiting enzyme in lactose biosynthesis. lactose is the main osmotic component of milk and may thereby affect milk volume. dietary protein inadequacy reduces milk volume and lactose content. the study investigates the role of ls activity in these phenomena. lactating rats were fed adequate and inadequate amounts of protein of high (milk protein) and low (cereal protein) q ... | 1987 | 3109312 |
| movements of vesicles on microtubules. | many cytoplasmic vesicles are observed to move along microtubules. often, bidirectional movement of particles is observed on a single microtubule. we have isolated one cytoplasmic motor, kinesin, and defined another, the axoplasmic retrograde factor, which are capable of powering anionic latex beads toward the plus and minus ends of microtubules, respectively. observations of vesicle movements show that vesicles have a defined direction of movement and that vesicles copurify with a kinesin motor ... | 2011 | 3109300 |
| movements of vesicles on microtubules. | many cytoplasmic vesicles are observed to move along microtubules. often, bidirectional movement of particles is observed on a single microtubule. we have isolated one cytoplasmic motor, kinesin, and defined another, the axoplasmic retrograde factor, which are capable of powering anionic latex beads toward the plus and minus ends of microtubules, respectively. observations of vesicle movements show that vesicles have a defined direction of movement and that vesicles copurify with a kinesin motor ... | 2011 | 3109300 |
| inner-city survey for tuberculosis: evaluation of diagnostic methods. | a total of 1,271 persons living in a socially and economically depressed, inner-city area of vancouver, british columbia, voluntarily attended a tuberculosis case-finding campaign. chest x-ray, on-the-spot specimen of sputum, and tuberculin skin test were offered at the time of the first attendance. all 3 diagnostic methods were found to be well accepted, with 93% of the participants having an x-ray, over 95% producing a sputum specimen, and almost 95% having a tuberculin test (a quarter of thes ... | 1987 | 3109292 |
| pulmonary clearance of pseudomonas aeruginosa in neutropenic mice. effects of systemic immunization. | systemic immunization with killed pseudomonas improves pulmonary clearance of these bacteria in normal mice. to test the effects of active systemic immunization on early pulmonary clearance of pseudomonas in neutropenic mice, balb/c mice were intraperitoneally immunized with 10(8) pseudomonas or injected with saline twice weekly for 2 wk. ten days after the last immunization, immunized and control mice received tail vein injections with either nitrogen mustard or saline daily for 3 days. two day ... | 1987 | 3109290 |
| [influence of bcg in the control of humoral deficiency induced by mastocytoma p-815]. | viable bcg bacilli, in a lipid emulsion, inoculated intravenously, were capable of reverting the profound humoral immunosuppression induced in adult dba/2 mice by the mastocytoma p-815. bcg increased not only the number of hemolytic plaque forming cells, but also the serum titers of hemagglutinating igm antibodies. however, no blocking effect was detected on normal tumor progression. | 1986 | 3108617 |
| in vivo studies on intracellular ph, focal flow, and vessel diameter in the cat cerebral cortex: effects of altered co2 and electrical stimulation. | the time course of changes in cortical tissue ph (phi) and blood flow during cortical seizures in halothane-anesthetized cats was examined. the clearance of the molecular form of umbelliferone (um) was used to estimate focal cortical blood flow (cbfu), whereas the ratio of the molecular to the ionic form of the molecule was used to concurrently calculate the local phi. resting phi and flow in normocarbic animals was 7.116 +/- 0.008 and 46 +/- 8 ml/100 g/min, respectively. respiratory induced alt ... | 1987 | 3108271 |
| osteonectin content in human osteogenesis imperfecta bone shows a range similar to that of two bovine models of oi. | samples of human osteogenesis imperfecta (oi) bone were analyzed for osteonectin content by sds gel electrophoresis and immunodetection on western blots. the oi bone osteonectin content varied from normal to severely depressed. previously, we showed that two clinically identical but genetically unrelated bovine models of oi were differentiated biochemically by their bone osteonectin content: one oi model had normal bone osteonectin while the other was severely depressed in this parameter. the da ... | 1987 | 3107778 |
| characterization of self-transmissible plasmids determining lactose fermentation and multiple antibiotic resistance in clinical strains of klebsiella pneumoniae. | the lactose fermentation (lac+) and antibiotic resistance (r+) phenotypes were conjugally transferred from klebsiella pneumoniae strains (k166, k182, k186, k218, and k220) to salmonella typhi, s. typhimurium, shigella flexneri, and vibrio cholerae. the genes for lactose fermentation and antibiotic resistance were located on the plasmids. further analysis of plasmid dna from these isolates indicated the presence of multiple plasmids (mr ranged less than 2.7 to 70 x 10(6)). the lac+r+ plasmids p16 ... | 1987 | 3107002 |
| coagulation defects of aflatoxin intoxicated rabbits. | twelve new zealand white rabbits were intoxicated with aflatoxin b1. most rabbits developed a coagulation defect near the time of death. immediately prior to death there were significant decreases in factors v, vii, and viii coagulant activities and fibrinogen concentration without a change in plasma fibrin(ogen) degradation product concentration, platelet number, and detectable plasma fibrin monomers. microscopic evidence of disseminated intravascular coagulation was present in one rabbit with ... | 1987 | 3103313 |
| salicylates inhibit paf-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective. | the cyclooxygenase inhibitors indomethacin, piroxicam, ibuprofen, naproxen and flurbiprofen failed to block rat paw oedema induced by paf-acether, whereas aspirin and sodium salicylate were effective. two mixed cyclooxygenase and lipoxygenase inhibitors ndga, bw 755c and dexamethasone reduced oedema in a dose - dependently. the selective paf-acether antagonist, bn 52021, was effective against paf-acether at 5 - 20 mg/kg. the lipoxygenase derivates may be involved in paw oedema induced by paf-ace ... | 1986 | 3103172 |
| doppler studies in the growth retarded fetus and prediction of neonatal necrotising enterocolitis, haemorrhage, and neonatal morbidity. | in 82 consecutive cases of intrauterine growth retardation managed by established criteria fetal doppler studies identified 29 fetuses with absence of end diastolic frequencies in the fetal aorta. these same fetuses were significantly more growth retarded (p less than 0.001) and had an earlier gestational age at delivery (p less than 0.001) than those with end diastolic frequencies present. a subgroup of these cases was analysed in more detail to examine the prognostic value of this phenomenon f ... | 2011 | 3101778 |
| on the mechanism of antithrombotic action of flavonoids. | flavonols (quercetin and rutin) and flavanes (cyanidol and meciadonol) were studied for their effect on non-enzymatic lipid peroxidation, lipoxygenase and cyclo-oxygenase activities, binding to albumin and platelet membranes. these biochemical properties of four flavonoids were compared with respect to their antithrombotic action in vivo and their efficacy at influencing the platelet-endothelium interaction in vitro. all four flavonoids inhibited the ascorbate-stimulated formation of malondialde ... | 1987 | 3101704 |
| aids policy development within the department of defense. | 2011 | 3100984 | |
| a strain of multiform cryptococcus neoformans. | 1986 | 3100152 | |
| separation and quantification of prostaglandins e1 and e2 as their panacyl derivatives using reverse phase high pressure liquid chromatography. | separation and quantification of prostaglandin e1 (pge1) and prostaglandin e2 (pge2) were achieved using reverse phase high performance liquid chromatography (hplc). panacyl bromide (p-(9-anthroyloxy)phenacyl bromide) (pab) derivatives of pge2 and pge1 were prepared. reverse phase hplc using a linear gradient of 56% to 80% acetonitrile in water containing 0.10% acetic acid gave baseline resolution of the two derivatives. a 3 um diameter particle, c18 column provided good resolution and reproduci ... | 1986 | 3099332 |
| effect of measles-virus infection and interferon treatment on invasiveness of shigella flexneri in hep2-cell cultures. | the influence of measles-virus infection on the invasiveness of shigella flexneri in hep2-cell cultures was studied. bacterial invasiveness was significantly enhanced in cell cultures incubated with virus before bacterial inoculation. this effect was a function of time after introduction of virus to the cell cultures and of the concentration of virus. the increase in bacterial invasiveness was observed before production of infectious virus particles and before a cytopathic effect was evident. a ... | 1986 | 3098977 |
| characterization and diagnostic application of a lipopolysaccharide core oligosaccharide-protein conjugate. | shigella sonnei phase ii core oligosaccharide (osphii) was linked covalently with protein (bovine serum albumin or tetanus toxoid) to obtain a conjugate (osphii-protein) of good immunogenicity in rabbits. anti-osphii-protein conjugate sera contained high levels of immunoglobulin g antibodies against the complete core region of sh. sonnei lipopolysaccharide. the antigenic relationships between lipopolysaccharides of r1, r3 and r4 core types using anti-osphii-protein sera were studied. these antis ... | 1986 | 3098854 |
| radioimmunoscintigraphy of human gastric carcinoma xenografts with 125i-labeled monoclonal antibody. | a monoclonal antibody (gc 302) established in our laboratory, which was reactive with gastric carcinoma and other epithelial carcinoma but not with normal gastric mucosa or other malignant tumors of mesenchymal origin, was used to investigate the radioimmunolocalization of tumors. various kinds of target cells (5 x 10(5)) were incubated with 125i-labeled gc 302, and radioactivity was determined with a gamma counter. it was shown that there was a 500- to 1,000-fold increase in counts for gastric ... | 1986 | 3098721 |
| signals in the phi 29 dna-terminal protein template for the initiation of phage phi 29 dna replication. | the protein-free terminal fragments hindiii b and l, from the left and right ends of phi 29 dna, respectively, but not internal fragments of similar size, were active as templates in the formation of the p3-damp initiation complex in an in vitro system containing purified phi 29 terminal protein p3 and dna polymerase p2, although the activity was lower than that obtained with the phi 29 dna-p3 complex. these results indicate the existence of specific sequences at the ends of phi 29 dna that allo ... | 1986 | 3097958 |
| rash mutants deficient in gtp binding. | single amino acid substitutions were introduced into a region of the rash protein (residues 116, 117, and 119) homologous to a variety of diverse gtp-binding proteins. each of the mutant p21 proteins displayed a significant reduction (10- to 5,000-fold) in gtp binding affinity. activated rash proteins deficient in gtp binding were unaltered in their ability to morphologically transform nih 3t3 cells. | 1986 | 3097518 |
| [prevalence of campylobacter jejuni complement fixing antibody in healthy people]. | 1986 | 3097197 | |
| noradrenergic and opioid mediation of tricyclic-induced reversal of escape deficits caused by inescapable shock pretreatment in rats. | the present study was undertaken to investigate the possible involvement of a noradrenergic and opioid mediation of the reversal by tricyclic antidepressants of escape deficits produced by inescapable shock pretreatment. rats were first exposed to 60 inescapable shocks (15 s duration, 0.8 ma, every min +/- 15 s) and 48 h later subjected, to daily shuttle-box sessions (30 trials/day, iti: 30 s) during 3 consecutive days. twice-daily ip injection of desipramine or clomipramine (total daily dose: 3 ... | 1986 | 3094068 |
| chloroalanyl antibiotic peptides: antagonism of their antimicrobial effects by l-alanine and l-alanyl peptides in gram-negative bacteria. | a large number of structurally diverse di- and tripeptides containing the alanine racemase inactivator beta-chloro-l-alanine (beta-cl-lala) have been synthesized, and their antibacterial properties in vitro have been evaluated. the dipeptides 1, 3-6, and 8-17 and the tripeptide 20 are all broad-spectrum antibacterial agents with considerable potency against both gram-positive and gram-negative species, but none of these peptides improves dramatically on the antibiotic efficacy of the previously ... | 1986 | 3093682 |
| treating erythema chronicum migrans of lyme disease. | the efficacy of antibiotic treatment of 117 patients with erythema chronicum migrans of lyme disease was evaluated in terms of the necessity for retreatment and the prevention of the late manifestations of lyme disease. fifty-six patients with a minor form of the illness did not require retreatment and did not develop late manifestations following antibiotic treatment. three pregnant patients were included in this group. fourteen of sixty-one patients with a major form of the illness required re ... | 2011 | 3093544 |
| role of glutathione in protecting endothelial cells against hydrogen peroxide oxidant injury. | to determine the mechanism responsible for the enhanced susceptibility of endothelial cells to oxidant injury in the absence of glucose, we induced endothelial cell injury with oxygen radicals in the presence of various oxygen radical scavengers and measured endothelial cell levels of glutathione after oxidant injury in the presence and absence of glucose. endothelial cells were damaged with toxic oxygen radicals generated by phorbol myristate acetate (pma)-activated polymorphonuclear leukocytes ... | 2010 | 3091744 |
| button wires in the treatment of mandibular fractures. | button wiring has been used as an alternative to eyelet wiring in the department of oral and dental surgery of birmingham general hospital since 1977. this clinical update reviews 65 patients with mandibular fractures in which button wires were utilised in their treatment. | 2010 | 3091722 |
| [cell proliferation in the carcinogenetic processes of tongue carcinoma induced by 4-nitroquinoline-1-oxide in rats. 1. relation between morphology and microvascular architecture of the filiform papillae of dorsal surface of the tongue in normal albino rats]. | 1986 | 3090703 | |
| disopyramide phosphate effects on slow and depressed fast responses. | we studied the effects of disopyramide phosphate on explanted neonatal rat ventricle cells exhibiting depressed fast responses or naturally occurring slow response action potentials together with automatic activity. disopyramide suppressed the spontaneous activity at a concentration of 2.5 micrograms/ml with a half-maximal value of 10 micrograms/ml. before spontaneous activity was lost, there was an increase in beating rate possibly related to membrane depolarization. in depressed fast and slow ... | 1986 | 3089566 |
| manpower and training. | 2011 | 3089508 | |
| transdermal glyceryl trinitrate. | 2011 | 3089054 | |
| study of aldose reductase inhibition in intact lenses by 13c nuclear magnetic resonance spectroscopy. | carbon-13 nuclear magnetic resonance spectroscopy has been used in the study of glucose metabolism, specifically aldose reductase inhibition, in intact rabbit lenses maintained in organ culture. this technique provides an effective method of screening potential inhibitors of aldose reductase under conditions that more closely approximate in vivo conditions than do earlier methods. the aspirin substitutes acetaminophen and ibuprofen were studied as aldose reductase inhibitors and were found to be ... | 1986 | 3088727 |
| the effect of the beta-carboline fg 7142 on the behaviour of male rats in a living cage: an ethological analysis of social and nonsocial behaviour. | the effects of fg 7142, a beta-carboline benzodiazepine receptor partial inverse agonist, on the social behavior of pair-housed rats were investigated. four 6-min dyadic social encounters in a living cage were observed in a paradigm in which one member of a pair of rats was injected. the four injection groups (n = 8) were vehicle control, and fg 7142 at 2.5, 5.0 and 10.0 mg/kg, respectively. all injections were administered 2 min before the start of the first observation trial. compared to the e ... | 1986 | 3088637 |
| autotransplantation of maxillary canine teeth. a follow-up of 35 cases up to 4 years. | 35 cases of autotransplantation of nonendodontically treated maxillary canines were followed for up to 4 years and were assessed according to loss of the transplanted tooth, onset of sensibility, mobility, intact lamina dura and presence of tooth resorption. the results of this study compare favourably with other studies and favour the hypothesis that little is to be gained by not endodontically treating autotransplanted teeth immediately after splint removal. it is also suggested that immobiliz ... | 2011 | 3088156 |
| indications for surgical removal of supernumerary teeth in the premaxilla. | usually supernumerary teeth in the maxilla are removed surgically, often due to retention of the permanent teeth in the region, but in certain cases the supernumerary teeth do not cause alterations in the eruption, position or integrity of the permanent dentition. this study was performed in order to review the indications for such surgical removal. the patient records of 208 patients with supernumerary teeth during the period of 1970-81 were reviewed retrospectively. of these patients, 52 non-o ... | 2011 | 3088155 |
| skeletal remodelling in the temporomandibular joint after oblique sliding osteotomy of the mandibular rami. | skeletal remodelling of the temporomandibular joints took place in 80% of cases after oblique sliding osteotomies of the rami. the new bone formation was found in both the condylar and temporal parts of the joint. it was mostly located on the posterior surface of the condyle and in the roof of the temporal part of the joint. no differences in skeletal remodelling were found between wiring and nonwiring cases. | 2011 | 3088149 |
| stimulation of arachidonic acid release and eicosanoid biosynthesis in an interleukin 2-dependent t cell line. | previous studies have provided pharmacologic evidence that t lymphocyte function may be regulated in part by the intracellular production of various arachidonic acid (aa) metabolites in response to cellular stimulation. however, the specific aa metabolic capabilities of homogeneous t cell populations have not been clearly defined. in the present studies, we have employed an accessory cell-free t cell line, ht-2, as a model system for the examination of stimulus-induced eicosanoid biosynthesis in ... | 2011 | 3088127 |