Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| effect of age and vaccination on extent and spread of chlamydia pneumoniae infection in c57bl/6 mice. | chlamydia pneumoniae is an obligate intracellular respiratory pathogen for humans. infection by c. pneumoniae may be linked etiologically to extra-respiratory diseases of aging, especially atherosclerosis. we have previously shown that age promotes c. pneumoniae respiratory infection and extra-respiratory spread in balb/c mice. | 2012 | 22594698 |
| chlamydia pneumoniae infection and cardiac risk factors in patients with myocardial infection. | evidences support the possible involvement of microorganisms such as chlamydia pneumonia in the pathogenesis of ischemic heart diseases through a chronic inflammatory process. the aim of this study was to determine the relation between chlamydia pneumoniae seropositivity with acute myocardial infarction and its related risk factors. | 2011 | 22577429 |
| detection of dna of chlamydophila psittaci in subjects with psoriasis: a casual or a causal link? | recent evidence indicates that subclinical infection by chlamydophila psittaci occurs in a significant percentage of patients with chronic inflammatory polyarthritis, including psoriatic arthritis. | 2012 | 22564212 |
| influence of age on the clinical differentiation of atypical pneumonia in adults. | the japanese respiratory society (jrs) scoring system is a useful tool for the early and simple presumptive diagnosis of atypical pneumonia (mycoplasma pneumoniae and chlamydia pneumoniae pneumonia). however, it has been suggested that it is difficult to diagnose atypical pneumonia in the elderly using this system. in the present study, we evaluated the accuracy and usefulness of the jrs scoring system for diagnosing atypical pneumonia in different age groups. | 2012 | 22563979 |
| involvement of ser94 in rnase hiii from chlamydophila pneumoniae in the recognition of a single ribonucleotide misincorporated into double-stranded dna. | we recently provided the first report that rnase hiii can cleave a dna-rn(1)-dna/dna substrate (rn(1), one ribonucleotide) in vitro. in the present study, mutagenesis analyses and molecular dynamics (md) simulations were performed on rnase hiii from chlamydophila pneumoniae ar39 (cprnase hiii). our results elucidate the mechanism of ribonucleotide recognition employed by cprnase hiii, indicating that the g95/k96/g97 motif of cprnase hiii represents the main surface interacting with single ribonu ... | 2012 | 22561532 |
| [etiology and biomarkers of systemic inflammation in mild to moderate copd exacerbations]. | the etiology of acute exacerbations of chronic obstructive pulmonary disease (copd) is heterogeneous and still under discussion. inflammation increases during exacerbation of copd. the identification of inflammatory changes will increase our knowledge and potentially guide therapy. | 2012 | 22552550 |
| aetiology of community-acquired pneumonia among adults in an h1n1 pandemic year: the role of respiratory viruses. | this study aimed to determine the aetiology of community-acquired pneumonia (cap) by adding polymerase chain reaction (pcr) to conventional methods and to describe the clinical and laboratory features between patients with bacterial pneumonia (bp) and viral pneumonia (vp). adults with cap admitted from november 2009 to october 2010 were included. demographics, comorbidities, severity and clinical features were recorded. conventional microbiological methods included blood and sputum cultures, acu ... | 2012 | 22549730 |
| chlamydia pneumoniae-specific ige is prevalent in asthma and is associated with disease severity. | several chlamydia pneumoniae (cp) biomarkers have been associated with asthma but cp-specific ige (cp ige) has not been investigated extensively. our objective was to investigate cp ige in community adult asthma patients. | 2012 | 22545149 |
| detection of mycoplasma pneumoniae and chlamydophila pneumoniae directly from respiratory clinical specimens using a rapid real-time polymerase chain reaction assay. | we developed a rapid real-time polymerase chain reaction assay for detecting mycoplasma pneumoniae and chlamydophila pneumoniae directly from respiratory specimens. this procedure provides over 5 times faster results compared to existing methods while maintaining equivalent detection rates for specimens containing limited target organisms. | 2012 | 22541789 |
| chlamydia infection in street youth: need for more aggressive screening programs. | to determine, first, the sexual practices among street youth in the ottawa-carleton, ontario region; second, the percentage of street youth who report previous sexually transmitted disease (std) screening; and third, the rate of previous infection with chlamydia trachomatis in this population. | 1996 | 22514416 |
| laboratory diagnosis of chlamydia pneumoniae infections. | chlamydia pneumoniae is an important cause of respiratory illness. there is a need for accurate and rapid laboratory diagnostic methods that will lead to improved patient care, appropriate use of antimicrobial therapy and a better understanding of the epidemiology of this emerging pathogen. culture is highly specific but is technically demanding, expensive, has a long turnaround time and its sensitivity is highly dependent on transport conditions. antigen detection tests such as enzyme immunoass ... | 1995 | 22514397 |
| chlamydia pneumoniae pneumonia: an evolving clinical spectrum. | chlamydia pneumoniae is a recently recognized respiratory tract pathogen. it accounts for 6 to 10% of all cases of community acquired pneumonia requiring admission to hospital. two patients hospitalized with c pneumoniae pneumonia are presented to illustrate its range of severity and the extrapulmonary manifestations. | 1995 | 22514396 |
| searching for helicobacter pylori and chlamydia pneumoniae in primary endodontic infections. | the purpose of this study was to search samples from primary endodontic infections for the presence of two common human bacterial pathogens - helicobacter pylori and chlamydia pneumoniae. | 2012 | 22509118 |
| prediction of genomic islands in three bacterial pathogens of pneumonia. | pneumonia is one kind of common infectious disease, which is usually caused by bacteria, viruses, or fungi. in this paper, we predicted genomic islands in three bacterial pathogens of pneumonia. they are chlamydophila pneumoniae, mycoplasma pneumoniae and streptococcus pneumoniae, respectively. for each pathogen, one clinical strain is involved. after implementing the cumulative gc profile combined with h and bcn index, eight genomic islands are found in three pathogens. among them, six genomic ... | 2012 | 22489145 |
| might infection explain the higher risk of coronary heart disease in south asians? systematic review comparing prevalence rates with white populations in developed countries. | south asians in developed countries such as the uk are at comparatively high risk of coronary heart disease for reasons which are not fully understood. one unexplored hypothesis is more infections in this ethnic group. this study assessed whether the prevalence of infections among south asians differs from that among white populations of european origin in developed countries. | 2012 | 22483355 |
| [analysis of airway secretion caused by chlamydophila pneumoniae and the suppressive effects brought about macrolide antibacterial agents]. | 2009 | 22452056 | |
| chronic infections & coronary artery disease with special reference to chalmydia pneumoniae. | studies on cardiovascular diseases (cvd) in india have shown about 10-20 per cent of cases with no obvious risk factors, raising a suspicion of infections as a cause. there is a paucity of data on this possible role of infections. this study was, therefore, undertaken to find out the association between infection due to chlamydia pneumoniae and other organisms and coronary artery disease (cad). | 2012 | 22446866 |
| development of multiplex real-time pcr for the rapid detection of five bacterial causes of community acquired pneumonia. | establishing a microbial diagnosis for patients with community-acquired pneumonia (cap) is still challenging and is often achieved in only 30-50% of cases. polymerase chain reaction (pcr) has been shown to be more sensitive than conventional microbiological methods and it could help to increase the microbial yield for cap patients. this study was designed to develop, optimize and evaluate multiplex real-time pcr as a method for rapid differential detection of five bacterial causes of cap namely ... | 2011 | 22433883 |
| the use of multiplex real-time pcr improves the detection of the bacterial etiology of community acquired pneumonia. | community-acquired pneumonia (cap) is still a major cause of morbidity and mortality especially to children and compromised hosts, such as the old and those with underlying chronic diseases. knowledge of pathogens causing cap constitutes the basis for selection of antimicrobial treatment. previous data have shown that etiological agents can be identified in only up to 50% of patients, but this figure can be improved by using polymerase chain reaction (pcr). this study was designed to evaluate mu ... | 2011 | 22433882 |
| genome-wide identification of chlamydia trachomatis antigens associated with trachomatous trichiasis. | chlamydia trachomatis is the leading infectious cause of blindness. the goal of the current study was to search for biomarkers associated with c. trachomatis-induced ocular pathologies. | 2012 | 22427578 |
| a combination of secondhand cigarette smoke and chlamydia pneumoniae accelerates atherosclerosis. | secondhand smoke (ss) induces chronic infection of endothelial cells by chlamydia pneumoniae (cpn) in vitro. we investigated the in vivo effect on atherosclerosis following exposure to ss and infection with cpn both independently and in combination in apoe-/- mice. | 2012 | 22410122 |
| [investigation of chlamydophila pneumoniae seropositivity and risk factors in patients with atherosclerotic vascular disease in sivas, turkey]. | the role of various microorganisms including chlamydophila (formerly chlamydia) pneumoniae, have been frequently investigated in the pathogenesis of atherosclerosis. in our study, the relationship between c.pneumoniae seropositivity and risk factors for atherosclerosis have been evaluated. a total of 90 atherosclerotic patients (71 of them were male; age range: 45-87 years; mean age: 65.3 ± 8.7 years) and 90 control subjects without coronary diseases (41 of them were male; age range: 42-84 years ... | 2012 | 22399186 |
| comparison of sputum and nasopharyngeal swab specimens for molecular diagnosis of mycoplasma pneumoniae, chlamydophila pneumoniae, and legionella pneumophila. | differentiation of atypical pathogens is important for community-acquired pneumonia (cap). in this study, we compared sputum and nasopharyngeal swabs (nps) for use in detection of mycoplasma pneumoniae (mp), chlamydophila pneumoniae (cp), and legionella pneumophila (lp), using seeplex pneumobacter ace detection assay (pneumobacter; seegene). | 2012 | 22389880 |
| chronic inflammation is correlated with percentage of body fat independent of the burden of infection. | the aim of this population-based study was to investigate the association of the percentage of body fat (bf) and high-sensitivity c-reactive protein (hs-crp) when the infectious burden was adjusted for. a total of 1,546 subjects were randomly selected. bf was determined using bioelectrical impedance analysis. sera were analyzed for igg antibodies to chlamydia pneumoniae, herpes simplex virus type 1, helicobacter pylori, and cytomegalovirus using elisa. measurement of c-reactive protein (crp) by ... | 2012 | 22382515 |
| association of influenza virus infection and inflammatory cytokines with acute myocardial infarction. | to explore the potential relationship between previous influenza virus (iv) infection and acute myocardial infarction (ami), and the mechanism of atherosclerosis, we conducted a case-control study and examined inflammatory cytokines to assess the association of previous iv infection and ami. | 2012 | 22373653 |
| evaluation of the level of antibodies against chlamydophila (chlamydia) pneumoniae in post-surgery heart ischaemia patients and their clinical conditions - a six-year study. | inflammatory conditions modulated by chlamydophila (chlamydia) pneumoniae are considered to play an important role in the onset of atherosclerosis. in this paper we present the results of progressive observation of c. pneumoniae antibody titres in patients who underwent coronary artery bypass graft (cabg). | 2010 | 22371750 |
| the relationship between seropositivity against chlamydia pneumoniae and stroke and its subtypes in a latvian population. | serological evidence of infection with chlamydia pneumoniae has been associated with cardiovascular diseases, but the relationship with stroke and its risk factors remains not completely understood. the aim of this study was to determine whether serological evidence of infection with chlamydia pneumoniae was associated with the risk of ischemic stroke and any of investigated stroke subtypes. | 2011 | 22370464 |
| serological investigation of pneumonia as it presents to the physician's office. | to define the etiology of pneumonia, using a battery of serological tests, among patients presenting to physicians' offices in cumberland county, nova scotia from july 2, 1989 to july 1, 1990. | 1993 | 22346468 |
| rnase hiii from chlamydophila pneumoniae can efficiently cleave double-stranded dna carrying a chimeric ribonucleotide in the presence of manganese. | two ribonuclease hs (rnase hs) have been found in chlamydophila pneumoniae, cprnase hii and cprnase hiii. this work is the first report that cprnase hiii can efficiently cleave dna-rn(1) -dna/dna (rn(1) , monoribonucleotide) in vitro in the presence of mn(2+) , whereas the enzymatic activity of cprnase hii on the same substrate was inhibited by mn(2+) and dependent on mg(2+) . however, the ability of both cprnase hs to cleave other alternative substrates (rna/dna hybrids and okazaki-like substra ... | 2012 | 22332714 |
| [serological findings of chlamydial pneumoniae in the czech republic--control group of patients examined in the study: chlamydia pneumoniae in the aetiology of keratoconjunctivitis sicca]. | one of the aims of iga ns-10016 project "chlamydia pneumoniae in the etiology of keratoconjunctivitis sicca" was to evaluate the serologic results regarding chlamydia infections in patients affected by keratoconjunctivitis sicca, and to compare these findings with serology tests of the control group. serologic examination comprised anti-lps (genus specific) antibodies detection, chlamydia pneumoniae and chlamydia trachomatis species specific antibodies and antibodies against chlamydia heat-shock ... | 2011 | 22329284 |
| synovial xanthomatosis: are there clues to mechanisms for this rare disease? | we report a 64-year-old man with arthritis and nodules to describe that this picture can be caused by normo-lipidemic xanthomas. light and electron microscopy (em) plus polymerase chain reaction (pcr) studies were performed for diagnosis and investigation. these showed features typical of xanthomas plus pcr and em evidence of possible infection with chlamydia pneumoniae as a pathogenetic mechanism deserving consideration. with such rare diseases, any clues to possible mechanisms seem important t ... | 2012 | 22322588 |
| [underestimated problem of chlamydia infections]. | microorganisms which belong to chlamydophila sp and chlamydia sp genus are intracellular pathogens with characteristic life cycle. in humans the most common infections are caused by chlamydophila pneumoniae i chlamydia trachomatis.these pathogens are mainly responsible for infections of upper respiratory tract, infections of urinary tract and conjunctivitis. they are also considered to take part in patophysiology of atherosclerosis, nervous system diseases and exacerbation of chronic respiratory ... | 2008 | 22320048 |
| genomic screening for chlamydophila pneumoniae-specific antigens using serum samples from patients with primary infection. | chlamydophila pneumoniae, an obligate intracellular human pathogen, causes respiratory tract infections. the most common techniques used for the serological diagnosis of c. pneumoniae infections are microimmunofluorescence tests and commercial serological elisa tests; these are based on the detection of antibodies against whole chlamydial elementary bodies and lipopolysaccharide/outer membrane protein, respectively. identification of more specific and highly immunodominant antigens is essential ... | 2012 | 22309593 |
| potential association of helicobacter cinaedi with atrial arrhythmias and atherosclerosis. | helicobacter cinaedi has been increasingly recognized as an emerging pathogen. reports of recurrent bacteremia and isolation of h. cinaedi organisms from a patient with myopericarditis led us to postulate that h. cinaedi is associated with chronic inflammatory cardiovascular diseases such as atrial arrhythmias and atherosclerosis. to assess any association of h. cinaedi with atrial arrhythmias, a retrospective case-control study of patients attending kumamoto university hospital from 2005 to 200 ... | 2012 | 22309125 |
| lack of association of conjunctival malt lymphoma with chlamydiae or helicobacter pylori in a cohort of chinese patients. | this study was conducted to detect microbial pathogens in conjunctival mucosa-associated lymphoid tissue (malt) lymphoma specimens in an attempt to determine possible associations between conjunctival malt lymphoma and microbial infections. | 2012 | 22293871 |
| nlrp3 inflammasome is a target for development of broad-spectrum anti-infective drugs. | we describe the molecular mode of action and pharmacodynamics of a new molecular entity (nme) that induces the nlrp3 inflammasome-mediated innate immune response. this innate response reduces the pathogen load in an experimentally induced methicillin-resistant staphylococcos aureus infection, enhances survival in an experimentally induced gram-negative bacteremia, and overrides the escape mechanism of an obligate intracellular pathogen, viz. chlamydia pneumoniae. furthermore, the nme is more eff ... | 2012 | 22290938 |
| antimicrobial activity of the novel pleuromutilin antibiotic bc-3781 against organisms responsible for community-acquired respiratory tract infections (cartis). | bc-3781 is an investigational semi-synthetic pleuromutilin antibiotic, which recently finished a clinical phase 2 trial in acute bacterial skin and skin structure infections. bc-3781 binds to the 50s ribosomal subunit and cross-resistance with other antimicrobial classes is uncommon. we evaluated the activity of bc-3781 against organisms responsible for community-acquired respiratory tract infections (cartis). | 2012 | 22287234 |
| structural analysis and serological test of arginine periplasmic binding protein 2 from chlamydophila pneumoniae. | the 'art' genes encode specific arginine uptake proteins, and are repressed by the repressible promoters of argr, affecting transcription of artj. cpb0502, the arginine-binding periplasmic protein 2 precursor from chlamydophila pneumoniae tw-183 strains, is responsible for arginine transport. as c. pneumoniae is difficult to isolate and culture, there have been many studies of better ways to detect it. a microimmunofluorescence assay (mif) is still considered to be the 'gold standard' for detect ... | 2012 | 22285188 |
| chlamydophila pneumoniae inhibits corticosteroid-induced suppression of metalloproteinase-9 and tissue inhibitor metalloproteinase-1 secretion by human peripheral blood mononuclear cells. | chlamydophila pneumoniae infection has been suggested to be associated with severe asthma characterized by persistent airway limitation, which may be related to airway remodelling. we investigated whether c. pneumoniae infection affected the secretion of metalloproteinase-9 (mmp9) and tissue inhibitor metalloproteinase-1 (timp1), and altered the responsiveness of inflammatory cells to corticosteroids. human peripheral blood mononuclear cells (pbmcs) were cultured in vitro in the presence or abse ... | 2012 | 22282461 |
| rac1 regulates the nlrp3 inflammasome which mediates il-1beta production in chlamydophila pneumoniae infected human mononuclear cells. | chlamydophila pneumoniae causes acute respiratory tract infections and has been associated with development of asthma and atherosclerosis. the production of il-1β, a key mediator of acute and chronic inflammation, is regulated on a transcriptional level and additionally on a posttranslational level by inflammasomes. in the present study we show that c. pneumoniae-infected human mononuclear cells produce il-1β protein depending on an inflammasome consisting of nlrp3, the adapter protein asc and c ... | 2012 | 22276187 |
| structural characterization of a novel chlamydia pneumoniae type iii secretion-associated protein, cpn0803. | type iii secretion (t3s) is an essential virulence factor used by gram-negative pathogenic bacteria to deliver effector proteins into the host cell to establish and maintain an intracellular infection. chlamydia is known to use t3s to facilitate invasion of host cells but many proteins in the system remain uncharacterized. the c. trachomatis protein ct584 has previously been implicated in t3s. thus, we analyzed the ct584 ortholog in c. pneumoniae (cpn0803) and found that it associates with known ... | 2012 | 22272312 |
| heterocyclic urea derivatives and methods of use thereof (wo2010142978). | a series of ureido derivatives incorporating a highly derivatized quinolone scaffold were prepared by a succession of original steps. the lead molecules of these compounds are the quinolone antibacterials of the nalidixic acid/ciprofloxacin type and they target, similar to these clinically used agents, the dna gyrase/topoisomerase iv of pathogenic bacteria. these new quinolones are claimed to act as efficient antibacterials against a large number of drug-resistant bacteria such as staphylococcus ... | 2012 | 22264034 |
| the molecular anatomy of human hsp60 and its similarity with that of bacterial orthologs and acetylcholine receptor reveal a potential pathogenetic role of anti-chaperonin immunity in myasthenia gravis. | heat-shock protein 60 (hsp60) is ubiquitous and highly conserved being present in eukaryotes and prokaryotes, including pathogens. this chaperonin, although typically a mitochondrial protein, can also be found in other intracellular sites, extracellularly, and in circulation. thus, it can signal the immune system and participate in the development of inflammation and immune reactions. both phenomena can be elicited by human and foreign hsp60 (e.g., bacterial groel), when released into the blood ... | 2012 | 22258649 |
| lack of effective anti-apoptotic activities restricts growth of parachlamydiaceae in insect cells. | the fundamental role of programmed cell death in host defense is highlighted by the multitude of anti-apoptotic strategies evolved by various microbes, including the well-known obligate intracellular bacterial pathogens chlamydia trachomatis and chlamydia (chlamydophila) pneumoniae. as inhibition of apoptosis is assumed to be essential for a successful infection of humans by these chlamydiae, we analyzed the anti-apoptotic capacity of close relatives that occur as symbionts of amoebae and might ... | 2012 | 22253735 |
| successful treatment of chlamydophila pneumoniae acute respiratory distress syndrome with extracorporeal membrane oxygenator: a case report and diagnostic review. | chlamydophila pneumoniae is a respiratory pathogen known to infect the upper and lower respiratory tracts. infection severity can range from sub-clinical pulmonary infection to acute respiratory distress syndrome. | 2012 | 22251792 |
| detection of igm and igg antibodies to chlamydophila pneumoniae in pediatric community-acquired lower respiratory tract infections. | context: chlamydophila pneumoniae (c. pneumoniae) is an emerging infectious agent with a spectrum of clinical manifestations including lower and upper respiratory tract infections. aims: to investigate the role of c. pneumoniae in community-acquired lower respiratory tract infections (lrtis) in children using serological tests. settings and design: two hundred children, age 2 months to 12 years, hospitalized for community-acquired lrtis were investigated for c. pneumoniae etiology. materials and ... | 2011 | 22234110 |
| chlamydophila pneumoniae phospholipase d (cppld) drives th17 inflammation in human atherosclerosis. | phospholipases are produced from bacterial pathogens causing very different diseases. one of the most intriguing aspects of phospholipases is their potential to interfere with cellular signaling cascades and to modulate the host-immune response. here, we investigated the role of the innate and acquired immune responses elicited by chlamydophila pneumoniae phospholipase d (cppld) in the pathogenesis of atherosclerosis. we evaluated the cytokine and chemokine production induced by cppld in healthy ... | 2012 | 22232679 |
| chlamydophila pneumoniae infection induced nodular vasculitis. | we present the case history of a 48-year-old male patient with chlamydophila (chlamydia) pneumoniae who developed a nodular vasculitis. he developed a cutaneous vasculitis with the onset of respiratory symptoms. the diagnosis of chlamydophila pneumoniae infection was based on serology. since this infection is very common in our population, although often asymptomatic, it should be systematically considered as a causative agent of nodular vasculitis. | 2011 | 22220148 |
| flotillin-1/reggie-2 contributes to chlamydia pneumoniae growth and associates with bacterial inclusion. | chlamydiae are obligate intracellular pathogens replicating only inside the eukaryotic host. here we studied the effect of human flotillin-1 protein on chlamydia pneumoniae growth in hl and a549 epithelial cell lines. rna interference was applied to disrupt flotillin-1-mediated endocytosis. host associated bacteria were detected by quantitative pcr, and c. pneumoniae growth was evaluated by inclusion counts. c. pneumoniae attachment to host cells was unaffected, but bacterial intracellular growt ... | 2012 | 22215737 |
| chlamydophila pneumoniae infection induces alterations in vascular contractile responses. | chlamydophila pneumoniae infection has been associated in previous studies with coronary artery disease. the live bacterium has been detected within atherosclerotic plaques and can induce the structural remodeling of the vessel wall. however, the direct effects of infection on the contractile characteristics of the arteries remain unknown. left anterior descending coronary arteries isolated from porcine hearts were dissected and placed in culture medium for 72 hours before infection with c. pneu ... | 2011 | 22214836 |
| the role of chlamydia and chlamydophila infections in reactive arthritis. | chlamydia trachomatis and chlamydophila pneumoniae are human pathogens; the former being the etiologic agent for trachoma as well as a prevalent sexually transmitted bacterium, while c. pneumoniae is a respiratory pathogen responsible for community-acquired pneumonia. patients with reactive arthritis show evidence of present or past chlamydial infection. chlamydia spp., has been strongly implicated as a triggering factor for reactive arthritis. we describe the simultaneous occurrence of c. pneum ... | 2012 | 22214635 |
| chlamydia pneumoniae induces a pro-inflammatory phenotype in murine vascular smooth muscle cells independently of elevating reactive oxygen species. | nadph oxidases (nox) are reactive oxygen species (ros) -generating enzymes that play important physiological roles in host defence and redox signalling. however, nox activity is upregulated in the vascular wall during atherosclerosis and contributes to plaque formation by promoting oxidative stress and inflammation. the bacterium, chlamydia pneumonia, has been detected in vascular smooth muscle cells (vsmcs) of human atheroma. we hypothesised that c. pneumoniae infection of vsmcs causes nox acti ... | 2011 | 22211630 |
| chlamydia pneumoniae entry into epithelial cells by clathrin-independent endocytosis. | a gram-negative obligate intracellular bacterium, chlamydia pneumoniae, is a common respiratory pathogen. here, we examined the invasion and attachment of c. pneumoniae k6 into nonphagocytic hl epithelial cell line by manipulating host plasma membranes by using cholesterol-depleting methyl-beta-cyclodextrin (mβcd) and cholesterol-loading mβcd complexed cholesterol (chol-mβcd). the invasion was attenuated by mβcd-treatment while chol-mβcd augmented the attachment and invasion. in addition, the in ... | 2011 | 22203235 |
| performance on a multipathogen external quality assessment (eqa) panel by different mono- and multiplex nucleic acid amplification tests. | an external quality assessment (eqa) panel consisting of a total of 48 samples in broncho alveolar lavage (bal) or transport medium was prepared in collaboration with quality control for molecular diagnostics (qcmd) (www.qcmd.org). the panel was used to assess the proficiency of the 3 laboratories that would be responsible to examine the 6000 samples to be collected in the grace network of excellence (www.grace-lrti.org). the main objective was to decide on the best performing testing approach f ... | 2011 | 22170925 |
| antibodies to common infectious agents in coronary artery disease patients with and without rheumatic conditions. | objectives. the mechanism linking inflammation to atherosclerosis is unknown. we have previously demonstrated a high occurrence of inflammation in the aortic adventitia of patients with coronary artery disease (cad), which was more pronounced in patients with inflammatory rheumatic diseases (irds), and which might be involved in the pathogenesis of cardiovascular disease. in theory, infections might play a role in the pathogenesis of vascular inflammation or atherosclerosis, or both. this study ... | 2011 | 22157685 |
| Macrolides in the treatment of asthma. | This review summarizes the importance of macrolide therapy in the treatment of asthma, discusses macrolide mechanisms of action, and outlines new clinical data supporting their use. The effects of macrolides on both the innate and adaptive immune responses are discussed. | 2012 | 22112996 |
| Infectious agents associated with schizophrenia: A meta-analysis. | Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and infec ... | 2011 | 22104141 |
| Frequent detection of respiratory agents by multiplex PCR on oropharyngeal samples in Swedish school-attending adolescents. | Abstract Background: Respiratory agents may be detected in the oropharynx of healthy individuals. The extent of this condition and the reasons behind it are largely unknown. The objective of this study was to determine the factors associated with the presence of respiratory agents in the oropharynx of adolescents healthy enough to attend school activities. Methods: On a single day in December, samples from the posterior wall of the oropharynx of adolescents aged 10-15 y were obtained using cot ... | 2011 | 22103467 |
| serosurvey of bacterial and viral respiratory pathogens among deployed u.s. service members. | respiratory illnesses can cause substantial morbidity during military deployments. bordetella pertussis, chlamydia pneumoniae, mycoplasma pneumoniae, adenovirus, parainfluenza, and respiratory syncytial virus (rsv) are hypothesized causes. | 2011 | 22099233 |
| toll-like receptors 2 and 4 regulate the frequency of ifnγ-producing cd4+ t-cells during pulmonary infection with chlamydia pneumoniae. | tlr2 and tlr4 are crucial for recognition of chlamydia pneumoniae in vivo, since infected tlr2/4 double-deficient mice are unable to control the infection as evidenced by severe loss of body weight and progressive lethal pneumonia. unexpectedly, these mice display higher pulmonary levels of the protective cytokine ifnγ than wild type mice. we show here, that antigen-specific cd4(+) t-cells are responsible for the observed ifnγ-secretion in vivo and their frequency is higher in tlr2/4 double-defi ... | 2011 | 22096480 |
| Corn Mint ( Mentha arvensis ) Extract Diminishes Acute Chlamydia pneumoniae Infection in Vitro and in Vivo. | Corn mint ( Mentha arvensis ) provides a good source of natural phenols such as flavone glycosides and caffeic acid derivatives, which may have prophylactic properties against inflammations. This study investigated whether corn mint extract would be beneficial against a universal respiratory tract pathogen, Chlamydia pneumoniae , infection. The extract inhibited the growth of C. pneumoniae CWL-029 in vitro in a dose-dependent manner. The inhibition was confirmed against a clinical isolate K7. T ... | 2011 | 22073967 |
| oxidized ldl promotes the mitogenic actions of chlamydia pneumoniae in vascular smooth muscle cells. | the atherogenic actions of chlamydia pneumoniae (c. pneumoniae), a common respiratory pathogen, are dependent upon a high-cholesterol environment in vivo. it is possible that oxidized low-density lipoprotein (oxldl) is responsible for promoting the atherogenic effects of c. pneumoniae through a stimulation of cell proliferation. this study determined whether oxldl can enhance the mitogenic action of c. pneumoniae in vascular smooth muscle cells (vsmcs) and the involvement of mitogen-activated pr ... | 2011 | 22072707 |
| berberine inhibits hep-2 cell invasion induced by chlamydophila pneumoniae infection. | this study investigated the inhibitory effects of berberine on chlamydophila (chlamydia) pneumoniae infection-induced hep-2 cell invasion and explored the possible mechanisms involved in this process. c. pneumoniae infection resulted in a significant increase in hep-2 cell invasion when compared with the control cells (p<0.01) in a matrigel invasion assay. this enhanced cell invasion was strongly suppressed by berberine (50 μm) (p<0.01). in a cell adhesion assay, the infection-induced hep-2 cell ... | 2011 | 22068503 |
| antigens of persistent chlamydia pneumoniae within coronary atheroma from patients undergoing heart transplantation. | aims in order for chlamydia pneumoniae to play a causative role in chronic human disease, it would need to persist within infected tissue for extended periods of time. current theory suggests that c pneumoniae may persist at the site of infection via an alternative replicative form, known as an aberrant body. methods a panel of c pneumoniae-specific antibodies upregulated by the aberrant body was used to probe tissue specimens from the coronary atheroma from 13 explanted hearts to identify patt ... | 2011 | 22049224 |
| recent publications in medical microbiology and immunology: a retrospective. | a look back is done to some clinical and basic research activities recently published in medical microbiology and immunology. the review covers clinical experiences and in vitro experiments to understand the emergency, pathogenicity, epidemic spread, and vaccine-based prevention of avian and swine-origin flu. some new developments and concepts in diagnosis, (molecular) epidemiology, and therapy of aids, viral hepatitis c, and herpesvirus-associated diseases are outlined. regulation of immune sys ... | 2011 | 22033658 |
| comparison of real-time pcr and a microimmunofluorescence serological assay for detection of chlamydophila pneumoniae infection in an outbreak investigation. | we assessed the performance of a recently validated real-time pcr assay and a commercially available microimmunofluorescence serologic test for the detection of chlamydophila pneumoniae infection during an outbreak. evaluation of specimens from 137 individuals suggests that real-time pcr holds greater utility as a diagnostic tool for early c. pneumoniae detection. | 2012 | 22031704 |
| outcome of chlamydia pneumoniae associated acute ischemic stroke in elderly patients: a case-control study. | background: limited data exists about the role of chlamydia pneumoniae elderly patients with acute ischemic stroke. objective: to study the role of c. pneumoniae in elderly patients (age more than 65years) with acute ischemic stroke and its impact on stroke out come. methods: we recruited 100 elderly patients with acute ischemic stroke and 100 age and sex matched controls over a period of 2years. igg and iga anti c. pneumoniae antibodies were measured by microimmunofluorescence technique in pati ... | 2011 | 22030154 |
| increased expression of cd11a and cd45 on leukocytes and decreased serum tnf-alpha levels in patients with isolated coronary artery ectasia. | aneurysm and ectasia have similar pathological pathways. th2-associated cytokines are stimulated by aneurismal tissue and correspondingly lack mediators associated with th1 response. in this study, we measured serum tnf-alpha and il-18 levels which are strong th1 stimulating cytokines and also investigated the expression of cd11a, cd11b, cd18 adhesion molecules and cd45 on leukocytes in patients with coronary artery ectasia (cae) and controls with normal coronary arteries (nca). | 2011 | 22029185 |
| functional analysis of the cytoskeleton protein mreb from chlamydophila pneumoniae. | in rod-shaped bacteria, the bacterial actin ortholog mreb is considered to organize the incorporation of cell wall precursors into the side-wall, whereas the tubulin homologue ftsz is known to tether incorporation of cell wall building blocks at the developing septum. for intracellular bacteria, there is no need to compensate osmotic pressure by means of a cell wall, and peptidoglycan has not been reliably detected in chlamydiaceae. surprisingly, a nearly complete pathway for the biosynthesis of ... | 2011 | 22022378 |
| seroprevalence of 13 common pathogens in a rapidly growing u.s. minority population: mexican americans from san antonio, tx. | abstract: | 2011 | 22018212 |
| pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis. | it is currently unclear what causes the chronic inflammation within atherosclerotic plaques. one emerging paradigm suggests that infection with bacteria and/or viruses can contribute to the pathogenesis of atherosclerosis either via direct infection of vascular cells or via the indirect effects of cytokines or acute phase proteins induced by infection at non-vascular sites. this paradigm has been supported by multiple epidemiological studies that have established positive associations between th ... | 2011 | 22012133 |
| The validity of the criteria for primary infection of Chlamydophila pneumoniae in children by measuring ELISA IgM antibodies. | As IgM antibody measurement by enzyme-linked immunosorbent assay (ELISA) has become possible for the serological diagnosis of Chlamydophila pneumoniae (C. pn) infection, the HITAZYME-ELISA method has become widely employed in Japan. However, in children, when the diagnostic criterion of primary infection is set at ID =1.1, the positive rate is higher than expected, and the potential for inaccurate reflection of the prevalence has been raised. In this study, we performed ROC analysis involving 13 ... | 2011 | 22009528 |
| genetic factors influence serological measures of common infections. | antibodies against infectious pathogens provide information on past or present exposure to infectious agents. while host genetic factors are known to affect the immune response, the influence of genetic factors on antibody levels to common infectious agents is largely unknown. here we test whether antibody levels for 13 common infections are significantly heritable. | 2011 | 21996708 |
| targeting of a chlamydial protease impedes intracellular bacterial growth. | chlamydiae are obligate intracellular bacteria that propagate in a cytosolic vacuole. recent work has shown that growth of chlamydia induces the fragmentation of the golgi apparatus (ga) into ministacks, which facilitates the acquisition of host lipids into the growing inclusion. ga fragmentation results from infection-associated cleavage of the integral ga protein, golgin-84. golgin-84-cleavage, ga fragmentation and growth of chlamydia trachomatis can be blocked by the peptide inhibitor wehd-fm ... | 2011 | 21990969 |
| the transcriptional landscape of chlamydia pneumoniae. | abstract: background: gene function analysis of the obligate intracellular bacterium chlamydia pneumoniae is hampered by the facts that this organism is inaccessible to genetic manipulations and not cultivable outside the host. the genomes of several strains have been sequenced; however, very little information is available on the gene structure and transcriptome of c. pneumoniae. results: using a differential rna-sequencing approach with specific enrichment of primary transcripts, we defined t ... | 2011 | 21989159 |
| a pilot study on the association between double positive chlamydia pneumoniae serology and serum lipid indices alterations in obese adult females. | to study the relationship between chlamydia pneumoniae serologic status and serum lipid abnormalities in apparently healthy obese female subjects living in urban areas. | 2011 | 21983298 |
| two cases of erythema exsudativum multiforme associated with chlamydia pneumoniae infection. | we report two cases of erythema exsudativum multiforme (eem) that we concluded were caused by infections with chlamydia pneumoniae. high titers of igg antibody for chlamydia pneumoniae were shown in the sera of both cases. one case showed the classical symptoms of pneumonia together with radiological changes in the chest; the other case did not show these symptoms. to the best of our knowledge, only three cases of erythema multiforme associated with chlamydia pneumoniae infection have been repor ... | 2011 | 21950477 |
| effects of coadministration of natural polyphenols with doxycycline or calcium modulators on acute chlamydia pneumoniae infection in vitro. | besides small molecules from medicinal chemistry, natural products are still major sources of innovative therapeutic agents for various conditions, including infectious diseases. here we present the first attempt to design a combination treatment targeted against chlamydia pneumoniae infection using coadministration of natural phenolics with calcium (ca(2+)) modulators, and also the concomitant administration of these compounds with doxycycline. an in vitro acute c. pneumoniae model in human lun ... | 2011 | 21934693 |
| Detection of Chlamydophila pneumoniae in cats with conjunctivitis. | To determine the presence of chlamydial species including recently described chlamydial agents as well as the human pathogen Chlamydophila pneumoniae in feline conjunctivitis. | 2011 | 21923826 |
| Does respiratory infection due to Chlamydia pneumoniae still exist? | 2011 | 21921229 | |
| chlamydia pneumoniae binds to the lectin-like oxidized ldl receptor for infection of endothelial cells. | the association of chlamydia pneumoniae and atherosclerosis has been well documented. recently, it has been demonstrated that c. pneumoniae up-regulates expression of the lectin-like ox-ldl receptor (lox-1) in endothelial cells. many of the pro-atherogenic effects of ox-ldl occur through its activation and uptake by lox-1. this class e scavenger receptor contains a carbohydrate-recognition domain common to the c type lectin family. previously, we have demonstrated that the major outer membrane p ... | 2012 | 21911078 |
| a nested multiplex polymerase chain reaction assay for the differential identification of three zooanthroponotic chlamydial strains in porcine swab samples. | porcine chlamydial infection is an enzootic infectious disease caused by multiple members of the family chlamydiaceae (e.g. chlamydophila abortus, chlamydia suis, and chlamydophila pneumoniae). rapid and accurate differentiation of these pathogens is critical in the control and prevention of disease. the aim of the current study was to develop a nested multiplex polymerase chain reaction (nmpcr) assay to simultaneously detect the 3 chlamydial pathogens in clinical samples. in the first round of ... | 2011 | 21908308 |
| [induction of proinflammatory cytokines and cell apoptosis by chlamydia pneumoniae cpn0810]. | to expresse the chlamydia pneumoniae cpn0810 in e.coli bl21, and to study weather could it inducing proinflamatory cytokines including tnf-α and il-6 in human monocytic (thp-1) and cell apoptosis. | 2011 | 21906466 |
| [The phylogenetic position of Chlamydia strains isolated from monkeys and humans with Chlamydial pathology in the family Chiamydiaceae. Genotypic and phenotypic properties of this pathogen]. | Based on the results of the comparative analysis concerning relatedness and evolutional difference of the 16S - 23S nucleotide sequences of the middle ribosomal cluster and 23S rRNA I domain, and based on identification of phylogenetic position for Chlamydophila pneumoniae and Chlamydia trichomatis strains released from monkeys, relatedness of the above stated isolates with similar strains released from humans and with strains having nucleotide sequences presented in the GenBank electronic datab ... | 2011 | 21899086 |
| Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients. | Chlamydia pneumoniae heat shock protein (HSP) 60 is known to contribute to the activation of inflammation. In addition, there are contradictory reports on C. pneumoniae and their role in activation of pathways (apoptotic/antiapoptotic/necrosis) in coronary artery disease (CAD). Hence, more studies are required to know the actual role of C. pneumoniae in activation of apoptotic/antiapoptotic/necrosis pathways. | 2011 | 21889313 |
| Mechanisms other than atherosclerosis in the partnership between chlamydia and stroke. | 2011 | 21886090 | |
| Intracellular bacteria and adverse pregnancy outcomes. | This review considers the role of intracellular bacteria in adverse pregnancy outcomes, such as miscarriage, stillbirths, and preterm labour. The cause of miscarriage, stillbirth and preterm labour often remains unexplained. Intracellular bacteria that grow either poorly or not at all on media used routinely to detect human pathogens could be the aetiological agents of these obstetric conditions. For example, Listeria monocytogenes and Coxiella burnetti are intracellular bacteria that have a pre ... | 2011 | 21884294 |
| seasonal variations of 15 respiratory agents illustrated by the application of a multiplex polymerase chain reaction assay. | abstract background: nucleic acid amplification tests are increasingly being used to diagnose viral and bacterial respiratory tract infections. the high sensitivity of these tests affects our understanding of the epidemiology of respiratory tract infections. we have assessed the detection rate of a multiplex real-time polymerase chain reaction (pcr) test, with emphasis on epidemiology and seasonal distribution of the most common respiratory tract infections. methods: seven thousand eight hundr ... | 2012 | 21867470 |
| Chlamydia and chronic arthritis. | Abstract Certain bacterial infections have been demonstrated to be causative of reactive arthritis. The most common bacterial trigger of reactive arthritis is Chlamydia trachomatis. Chlamydia pneumoniae is another known cause, albeit far less frequently. Although Chlamydia-induced reactive arthritis will often spontaneously remit, approximately 30% of patients will develop a chronic course. Modern medicine has provided rather remarkable advances in our understanding of the chlamydiae, as these o ... | 2011 | 21864020 |
| pulmonary haptoglobin and cd163 are functional immunoregulatory elements in the human lung. | background: the acute-phase protein haptoglobin (hp) and its receptor cd163 serve as immunomodulators and possess anti-inflammatory besides antioxidant functions. objectives: to further understand the role of the recently described pulmonary hp (php) and its receptor cd163 in case of inflammation and infection, php and cd163 were investigated on mrna and protein level to gain insight into the cellular events taking place upon stimulation with the inflammatory mediators lps, pam3, cytokine il-6 a ... | 2011 | 21860221 |
| [comparison of echocardiographic findings in avs patients with and without high igg, igm, iga titers against chlamydia pneumoniae during 12 months' observation of avs natural course]. | comparison of echocardiographic findings in avs patients with and without high igg, igm, iga titers against chlamydia pneumoniae during 12 months' observation of avs natural course. | 2011 | 21853675 |
| sequence homologies between mycoplasma and chlamydia spp. lead to false-positive results in chlamydial cell cultures tested for mycoplasma contamination with a commercial pcr assay. | mycoplasma contamination is a frequent problem in chlamydial cell culture. after obtaining contradictory contamination results, we compared three commercial pcr kits for mycoplasma detection. one kit signaled contamination in mycoplasma-free chlamydia pneumoniae cultures. sequencing of cloned pcr products revealed primer homology with the chlamydial genome as the basis of this false-positive result. | 2011 | 21849688 |
| nifedipine affects the course of salmonella enterica serovar typhimurium infection by modulating macrophage iron homeostasis. | background.ôçâiron overload can adversely influence the course of infection by increasing microbial replication and suppressing antimicrobial immune effector pathways. recently, we have shown that the calcium channel blocker nifedipine can mobilize tissue iron in mouse models of iron overload. we therefore investigated whether nifedipine treatment affects the course of infection with intracellular bacteria via modulation of iron homeostasis. methods. the effect of nifedipine on intramacrophage r ... | 2011 | 21844295 |
| acute and chronic chlamydia pneumoniae infection and inflammatory markers in coronary artery disease patients. | we evaluated the role of inflammation and acute or persistent chlamydia pneumoniae infection in coronary artery disease (cad). -á-á-á-á | 2011 | 21841301 |
| microorganisms and valve tissue/ demonstration of chlamydophila pneumoniae, mycoplasma pneumoniae, cytomegalovirus, and epstein-barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction. | 2011 | 21827993 | |
| estrella lausannensis, a new star in the chlamydiales order. | originally, the chlamydiales order was represented by a single family, the chlamydiaceae, composed of several pathogens, such as chlamydia trachomatis, chlamydia pneumoniae, chlamydia psittaci and chlamydia abortus. recently, 6 new families of chlamydia-related bacteria have been added to the chlamydiales order. most of these obligate intracellular bacteria are able to replicate in free-living amoebae. amoebal co-culture may be used to selectively isolate amoeba-resisting bacteria. this method a ... | 2011 | 21816232 |
| investigation of bacterial and viral agents and immune status in behcet's disease patients from iran. | aim:ôçé beh+ºet's disease (bd) is an autoimmune disorder associated with hla-b51 positivity. serologic/genomic findings have suggested microbes as possible causative agents and the geographical distribution suggests environmental influences. methods:ôçé we performed comparative analyses of 40 patients with bd or related symptoms not fulfilling bd criteria. patients originating from different regions of iran were tested by molecular/serological methods for human herpes viruses and parvovirus b19, ... | 2011 | 21816027 |
| mycoplasma pneumoniae and chlamydia pneumoniae seropositivity in patients with age-related macular degeneration. | to determine a possible relation between mycoplasma pneumoniae (mp) or chlamidia pneumoniae (cp) seropositivity and age-related macular degeneration (amd). | 2010 | 21811525 |
| chlamydia pneumoniae seropositivity in adults with acute ischemic stroke: a case-control study. | causative role of chlamydia pneumoniae infection in patients with acute ischemic stroke (ais) remains unresolved till date. | 2011 | 21808469 |
| induction of proinflammatory cytokines in human osteoblastic cells by chlamydia pneumoniae. | chlamydia pneumoniae is an obligate intracellular gram-negative bacterium that causes recurrent pharyngitis, pneumonia and chronic inflammation induced by cycles of persistence and productive infection that might also explain the association with chronic diseases. the aim of this study was to determine whether c. pneumoniae can invade and survive within human osteoblasts and whether this infection elicits the secretion of proinflammatory cytokines. our results demonstrated that c. pneumoniae was ... | 2011 | 21803599 |