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assessment of pre- and post-operative cerebral perfusion in anterior circulation intracranial aneurysm clipping patients at hospital sungai buloh using ct perfusion scan and correlations to fisher, navarro and wfns scores.intracranial aneurysms may rupture and are typically associated with high morbidity and mortality, commonly due to vasospasm after rupture. once the aneurysm ruptures, the patient's cerebral blood flow may be disturbed during the acute phase, affecting cerebral circulation and thus cerebral perfusion prior to the onset of vasospasm. fisher and navarro scores are used to predict vasospasm, while world federation of neurosurgical societies (wfns) scores are used to predict patient outcomes. severa ...201728461780
influence of cement type and ceramic primer on retention of polymer-infiltrated ceramic crowns to a one-piece zirconia implant.the best procedure for cementing a restoration to zirconia implants has not yet been established.201728461047
novel oxytocin receptor variants in laboring women requiring high doses of oxytocin.although oxytocin commonly is used to augment or induce labor, it is difficult to predict its effectiveness because oxytocin dose requirements vary significantly among women. one possibility is that women requiring high or low doses of oxytocin have variations in the oxytocin receptor gene.201728456503
body frame size in school children is related to the amount of adipose tissue in different depots but not to adipose distribution.the main aim of this study was to test the hypothesis that body frame size is related to the amount of fat in different adipose tissue depots and to fat distribution in schoolchildren.201728455842
wright-fisher exact solver (wfes): scalable analysis of population genetic models without simulation or diffusion theory.the simplifying assumptions that are used widely in theoretical population genetics may not always be appropriate for empirical population genetics. general computational approaches that do not require the assumptions of classical theory are therefore quite desirable. one such general approach is provided by the theory of absorbing markov chains, which can be used to obtain exact results by directly analyzing population genetic markov models, such as the classic bi-allelic wright-fisher model. a ...201728453671
the effect of hiv-centered obstetric care on perinatal outcomes among a cohort of women living with hiv.elimination of perinatal transmission is possible but limited by missed care opportunities. our objective was to investigate the effects of hiv-centered obstetric care (hcc) on missed care opportunities and perinatal hiv transmission in 2 obstetric cohorts at our institution from 2000 to 2014.201728452911
kaolin-based hemostatic dressing improves hemorrhage control from a penetrating inferior vena cava injury in coagulopathic swine.retrohepatic inferior vena cava (rivc) injuries are often lethal due to challenges in obtaining hemorrhage control. we hypothesized that packing with a new kaolin-based hemostatic dressing (control+; z-medica, wallingford, ct) would improve hemorrhage control from a penetrating rivc injury compared with packing with standard laparotomy sponges alone.201728452883
mixture risk assessment due to ingestion of arsenic, copper, and zinc from milkfish farmed in contaminated coastal areas.human health risks associated with the consumption of metal-contaminated fish over extended periods have become a concern particularly in taiwan, where fish is consumed on a large scale. this study applied the interaction-based hazard index (hi) to assess the mixture health risks for fishers and non-fishers who consume the arsenic (as), copper (cu), and zinc (zn) contaminated milkfish from as-contaminated coastal areas in taiwan, taking into account joint toxic actions and potential toxic intera ...201728452032
c5 palsy after cervical spine surgery: a multicenter retrospective review of 59 cases.a multicenter, retrospective review of c5 palsy after cervical spine surgery.201728451494
serial neurophysiological and neurophysiological examinations for delayed facial nerve palsy in a patient with fisher syndrome.the patient was a 47-year-old man who presented with diplopia and gait instability with a gradual onset over the course of three days. neurological examinations showed ophthalmoplegia, diminished tendon reflexes, and truncal ataxia. tests for anti-gq1b antibodies and several other antibodies to ganglioside complex were positive. we made a diagnosis of fisher syndrome. after administration of intravenous immunoglobulin, the patient's symptoms gradually improved. however, bilateral facial palsy ap ...201728450686
a study of single nucleotide polymorphisms of tumour necrosis factor α-1031 and tumour necrosis factor β+ 252 in chronic rhinosinusitis.this case-controlled study aimed to identify the association of tumor necrosis factor (tnf)α-1031 and tnfβ+ 252 gene polymorphisms between chronic rhinosinusitis (crs) and healthy controls. another purpose of this study was to investigate the associations of these gene polymorphisms with factors related to crs.201728449554
[prognostic factors for post surgical complications in bone infection and pseudarthrosis].bone infection and nonunion are the main orthopedic and traumatic complications whose treatment remains a challenge because multiple factors are involved in the rate of failures when you try to correct them. knowing these factors were the problem that caused the research through a prospective longitudinal study of 83 patients of 43.3 ± 16.1 years old. they were treated for aseptic and septic nonunion, osteomyelitis, osteitis, malunion or infected joint replacement. the cases were classified with ...201728448706
clinical significance of incidentally detected torus tubarius calcification.calcification of the torus tubarius has been rarely reported in the literature. histopathologic studies have previously described cases of eustachian tube calcification and cite an association with increasing patient age. the purpose of this study was to examine the prevalence of torus tubarius calcification and potential clinical significance on an unrestricted patient population using thin-section computed tomography (ct), which has not been previously reported.201728448401
comparison of the natural history of genital hpv infection among men by country: brazil, mexico, and the united states.background: male genital human papillomavirus (hpv) prevalence and incidence has been reported to vary by geographical location. our objective was to assess the natural history of genital hpv by country among men with a median of 48 months of follow-up.methods: men ages 18-70 years were recruited from united states (n = 1,326), mexico (n = 1,349), and brazil (n = 1,410). genital specimens were collected every 6 months and hpv genotyping identified 37 hpv genotypes. prevalence of hpv was compared ...201728446543
possible pathways used to predict different stages of lung adenocarcinoma.we aimed to find some specific pathways that can be used to predict the stage of lung adenocarcinoma.rna-seq expression profile data and clinical data of lung adenocarcinoma (stage i [37], stage ii 161], stage iii [75], and stage iv [45]) were obtained from the tcga dataset. the differentially expressed genes were merged, correlation coefficient matrix between genes was constructed with correlation analysis, and unsupervised clustering was carried out with hierarchical clustering method. the spe ...201728445293
detection of immunoglobulin heavy chain gene clonality by next-generation sequencing for minimal residual disease monitoring in b-lymphoblastic leukemia.minimal residual disease (mrd) following b-lymphoblastic leukemia (b-all) treatment has gained prognostic importance. clonal immunoglobulin heavy chain (igh) gene rearrangement is a useful follow-up marker in b-all owing to its high positivity rate. we evaluated the performance and clinical applicability of a next-generation sequencing (ngs) assay for igh rearrangement in b-all mrd monitoring. igh rearrangement was tested by using fluorescence pcr-fragment analysis and the ngs assay in eight b-a ...201728445014
[atypical guillain-barre syndrome clustering: is it necessary to reconsider the diagnostic criteria and microbiological protocol?]guillain-barre syndrome is classically defined as a symmetrical ascending acute polyradiculoneuropathy, although there are atypical variants that make diagnosis difficult.201728444683
application of high-speed t1 sequences for high-quality hepatic arterial phase magnetic resonance imaging: intraindividual comparison of single and multiple arterial phases.the aim of this study was to compare intraindividual single and multiple arterial phase acquisitions and evaluate which acquisition method was more advantageous for obtaining high-quality hepatic arterial phase in gadoxetic acid-enhanced liver magnetic resonance imaging (mri).201728441159
morphological features and prognostic significance of arid1a-deficient esophageal adenocarcinomas.- the clinicopathologic and prognostic significance of arid1a mutation in esophageal adenocarcinoma (eac) is unknown.201728440661
determinants of health facility delivery among women in tharaka nithi county, kenya.kenya records a high maternal mortality ratio 362 maternal deaths per 100 000 live births. tharaka sub county has poor transport infrastructure, low levels of socio-economic status and long distances to health facilities. secondary to these factors, delivering in a health facility is a challenge. delivering in a health facility is one of the strategies to avert maternal death through skilled birth attendance. the aim of the study was to evaluate the determinants of health facility delivery among ...201628439333
erratum to: riverine fishers' knowledge of extreme climatic events in the brazilian amazonia. 201728438172
comparison of the timing of intervention and treatment modality of poor-grade aneurysmal subarachnoid hemorrhage.the timing and modality of intervention in the treatment of poor-grade aneurysmal subarachnoid haemorrhage (asah) has not been defined. the purpose of the study is to analyse whether early treatment and type of intervention influence the clinical outcomes of poor-grade asah patients.201728436243
an improved uniformly more powerful exact fisher-hayter pairwise comparisons procedure.pairwise comparison is a very common multiple comparison problem. it is known that fisher's lsd test does not control the familywise error rate (fwer) when there are more than three groups to be compared. improved testing strategies include the tukey-kramer (tk) test that eliminates the f-test step and the two-step fisher-hayter (fh) test which requires a significant f-test. we propose a modified fh-test that is uniformly more powerful than the original version and relies on exact size α test un ...201728436123
primary repair of traumatic distal biceps ruptures in a military population: clinical outcomes of single- versus 2-incision technique.to determine the success of distal biceps repair in a high-demand military population and to comparatively evaluate the perioperative risk profile, functional results, and adverse patient outcomes of a single- versus 2-incision technique within this high-risk group.201728431883
prospective cluster controlled crossover trial to compare the impact of an improved hydrogen peroxide disinfectant and a quaternary ammonium-based disinfectant on surface contamination and health care outcomes.quaternary ammonium-based (quat) disinfectants are widely used, but they have disadvantages.201728431849
non-response to fluconazole maintenance treatment (recidif regimen) for recurrent vulvovaginal candidosis is not related to impaired glucose metabolism.is non-response to maintenance treatment for recurrent vulvovaginal candidosis (rcvv) related to the impaired glucose metabolism? in the recidif trial, women with rcvv were given a degressive regimen with fluconazole according to their clinical, microscopic and mycologic response. data obtained from optimal, suboptimal and non-reponding patients were used for secondary analysis of medical history, physical status and family history for potential glucose impairment. results were presented in mean ...201728429840
the multi-faceted dynamics of hiv-1 transmission in northern alberta: a combined analysis of virus genetic and public health data.molecular epidemiology has become a key tool for tracking infectious disease epidemics. here, the spread of the most prevalent hiv-1 subtypes in northern alberta, canada, was characterized with a bayesian phylogenetic approach using 1146 hiv-1 pol sequences collected between 2007 and 2013 for routine clinical management purposes. available patient metadata were qualitatively interpreted and correlated with onwards transmission using fisher exact tests and logistic regression. most infections wer ...201728427935
individual-based modelling of population growth and diffusion in discrete time.individual-based models (ibms) of human populations capture spatio-temporal dynamics using rules that govern the birth, behavior, and death of individuals. we explore a stochastic ibm of logistic growth-diffusion with constant time steps and independent, simultaneous actions of birth, death, and movement that approaches the fisher-kolmogorov model in the continuum limit. this model is well-suited to parallelization on high-performance computers. we explore its emergent properties with analytical ...201728426763
loop ileostomy versus total colectomy as surgical treatment for clostridium difficile-associated disease: an eastern association for the surgery of trauma multicenter trial.the mortality of patients with clostridium difficile-associated disease (cdad) requiring surgery continues to be very high. loop ileostomy (li) was introduced as an alternative procedure to total colectomy (tc) for cdad by a single-center study. to date, no reproducible results have been published. the objective of this study was to compare these two procedures in a multicentric approach to help the surgeon decide what procedure is best suited for the patient in need.201728426557
lung function and prevalence of respiratory symptoms in norwegian crab processing workers.seafood processing workers have an increased risk of developing occupational asthma. this has not been studied among norwegian crab processing workers, nor has the respiratory health of exposed workers been compared to a control group.201728425826
violence against women, espírito santo, brazil.to estimate the prevalence and factors associated with psychological, physical and sexual violence in women victims of intimate partner violence assisted in the primary care services.201728423136
validation and optimization of the ion torrent s5 xl sequencer and oncomine workflow for brca1 and brca2 genetic testing.in this study, we validated the analytical performance of brca1/2 sequencing using ion torrent's new bench-top sequencer with amplicon panel with optimized bioinformatics pipelines. using 43 samples that were previously validated by illumina's miseq platform and/or by sanger sequencing/multiplex ligation-dependent probe amplification, we amplified the target with the oncomine™ brca research assay and sequenced on ion torrent s5 xl (thermo fisher scientific, waltham, ma, usa). we compared two bio ...201728422718
correlated topic vector for scene classification.scene images usually involve semantic correlations, particularly when considering large-scale image data sets. this paper proposes a novel generative image representation, correlated topic vector, to model such semantic correlations. oriented from the correlated topic model, correlated topic vector intends to naturally utilize the correlations among topics, which are seldom considered in the conventional feature encoding, e.g., fisher vector, but do exist in scene images. it is expected that the ...201728422661
otolaryngology residency program research resources and scholarly productivity.objective to delineate research resources available to otolaryngology residents and their impact on scholarly productivity. study design survey of current otolaryngology program directors. setting otolaryngology residency programs. subjects and methods an anonymous web-based survey was sent to 98 allopathic otolaryngology training program directors. fisher exact tests and nonparametric correlations were used to determine statistically significant differences among various strata of programs. res ...201728419807
antepartum management and obstetric outcomes among pregnancies with down syndrome from diagnosis to delivery.little is known about the obstetric care of an ongoing pregnancy with trisomy 21. we sought to ascertain an obstetric profile for pregnancies with down syndrome to help guide prenatal management.201728419500
incorporating a modified graeb score to the modified fisher scale for improved risk prediction of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage.delayed cerebral ischemia (dci) is a cause of poor outcome after aneurysmal subarachnoid hemorrhage. risk scales to predict dci have scarcely been evaluated for predictive accuracy. accounting for volume of intraventricular hemorrhage (ivh) in the modified fischer scale (mfs) may improve its predictive accuracy.201728419304
impact of ultrasound on short peripheral intravenous catheter placement on vein thrombosis risk.approximately 90% of hospitalized patients have a short peripheral intravenous catheter (spc) placed. methods of inserting the catheter have evolved over time and now include the use of ultrasound (us)-guided procedures for placement. little is known about the impact that us-guided procedures have on the vein. this study compared the rate of venous thrombosis in patients with and without us-guided catheter placement. this prospective, single-blind, observational study assessed for venous thrombo ...201728419014
delineating parameter unidentifiabilities in complex models.scientists use mathematical modeling as a tool for understanding and predicting the properties of complex physical systems. in highly parametrized models there often exist relationships between parameters over which model predictions are identical, or nearly identical. these are known as structural or practical unidentifiabilities, respectively. they are hard to diagnose and make reliable parameter estimation from data impossible. they furthermore imply the existence of an underlying model simpl ...201728415348
compressible cell gas models for asymmetric fluid criticality.we thoroughly describe a class of models recently presented by fisher and coworkers [phys. rev. lett. 116, 040601 (2016)]prltao0031-900710.1103/physrevlett.116.040601. the crucial feature of such models, termed compressible cell gases (ccgs), is that the individual cell volumes of a lattice gas are allowed to fluctuate. they are studied via the seldom-used (μ, p, t) ensemble, which leads to their exact mapping onto the ising model. remarkably, ccgs obey complete scaling, a formulation for the th ...201728415250
clinicopathological study of 18 cases of inflammatory myofibroblastic tumors with reference to alk-1 expression: 5-year experience in a tertiary care center.inflammatory myofibroblastic tumor is a histopathologically distinctive neoplasm of children and young adults. according to world health organization (who) classification, inflammatory myofibroblastic tumor is an intermediate-grade tumor, with potential for recurrence and rare metastasis. there are no definite histopathologic, molecular, or cytogenetic features to predict malignant transformation, recurrence, or metastasis.201728415158
quantifying the potential and flux landscapes of multi-locus evolution.exploration of multi-locus evolution is critically important for understanding evolutionary dynamics. recombination and epistasis lead to complex evolutionary dynamics. quantifying the stability and function of such multi-locus evolutionary systems globally is a long-standing challenge for evolutionary biologists. the conventional wright, fisher and quasi-linkage equilibrium (qle) theories can only be applied to highly restricted, simplified and special evolutionary scenarios. in this study, we ...201728414087
transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord.we have previously reported elevated expression of multiple pro-inflammatory markers in the lumbar spinal cord (lsc) of middle-aged male rats compared to young adults suggesting a para-inflammatory state develops in the lsc by middle age, a time that in humans is associated with the greatest pain prevalence and persistence. the goal of the current study was to examine the transcriptome-wide gene expression differences between young and middle aged lsc.201728413428
[preliminary report on the application of femtosecond laser-assisted anterior capsulotomy in intumescent white cataract surgery].objective: to assess the effect of femtosecond laser-assisted anterior capsulotomy in intumescent white cataract surgery. methods: retrospective case series study. one hundred and fifty cataract patients (150 eyes) from june 2014 to june 2015 in wuhan aier ophthalmology hospital were enrolled in this study. they were divided into three groups: 50 intumescent white cataract patients (50 eyes) in the study group were performed femtosecond laser-assisted capsulotomy (lensx system) operation selecti ...201728412801
shockwave lithotripsy with music: less painful and more satisfactory treatment.the objective of this study was to determine whether listening to music during a session of extracorporeal shockwave lithotripsy (eswl) improves patients' pain.201728412009
the effect of user experience and inflation technique on endotracheal tube cuff pressure using a feline airway simulator.the effect of user experience and inflation technique on endotracheal tube cuff pressure using a feline airway simulator.201728410880
resident doctors' attitudes toward tuberculosis patients.the attitude of the resident doctors toward tuberculosis (tb) patients can affect their treatment seeking behavior, compliance to treatment as well as reinforce the stigma attached to the disease by the society at large.201728410704
predictors of postoperative cerebral ischemia in patients with ruptured anterior communicating artery aneurysms.cerebral ischemia is a major contributor to poor outcome after ruptured anterior communicating artery aneurysms (acoas), and is not well classified. in this article, we develop a classification and identify risk factors of cerebral ischemia after ruptured acoas.201728408258
plasma 8-iso-prostaglandin f2α, a possible prognostic marker in aneurysmal subarachnoid hemorrhage.8-iso-prostaglandin f2α (8-iso-pgf2α) is a potential biomarker of oxidative stress. this study clarified whether plasma 8-iso-pgf2α concentrations were affected and its underlying relevance to prognosis in aneurysmal subarachnoid hemorrhage (asah).201728408198
high risk of coronary artery aneurysms in infants younger than 6 months of age with kawasaki disease.to characterize the clinical presentation and outcome in infants <6 months of age with kawasaki disease (kd) and to describe the use of newer anti-inflammatory therapies in this young population.201728408126
micro-level explanations for emergent patterns of self-governance arrangements in small-scale fisheries-a modeling approach.small-scale fisheries (ssfs) in developing countries are expected to play a significant role in poverty alleviation and enhancing food security in the decades to come. to realize this expectation, a better understanding of their informal self-governance arrangements is critical for developing policies that can improve fishers' livelihoods and lead to sustainable ecosystem stewardship. the goal of this paper is to develop a more nuanced understanding of micro-level factors-such as fishers' charac ...201728406935
a retrospective comparison between transrectal and transperineal prostate biopsy in the detection of prostate cancer.the aim of this study was to analyze the differences between trusguided transrectal prostate biopsy (tr) and transperineal prostate biopsy (tp) in the diagnosis of prostate cancer. the two biopsy methods were evaluated in terms of diagnostic sensitivity and of early and late complications.201728403597
subclinical hypothyroidism and the risk of chronic kidney disease in t2d subjects: a case-control and dose-response analysis.evidence indicated a positive association between subclinical hypothyroidism (sch) and cardiovascular diseases. but the relationship between sch and chronic kidney diseases (ckd) remains unclear. a case-control study was performed to ascertain this relationship followed by a meta-analysis. in this hospital-based, case-control study, we recruited 3270 type 2 diabetic patients with euthyroidism and 545 type 2 diabetic patients with sch. all english studies were searched upon the relationship betwe ...201728403083
p16ink4a, cytokeratin 7, and ki-67 as potential markers for low-grade cervical intraepithelial neoplasia progression.the aim of this study was to evaluate p16, cytokeratin 7 (ck7), and ki-67 immunoexpressions in low-grade squamous intraepithelial lesion (lsil), looking for differences among cases that progress to high-grade squamous intraepithelial lesion, maintain lsil, or regress.201728403025
incidence of le fort surgery in a mature cohort of patients with cleft lip and palate.primary repair of cleft lip and palate occurs early in life, but ideal timing of these interventions remains controversial. prior research has indicated that a later palate repair may improve patients' midfacial growth long term, whereas optimal timing of lip repair to maximize midfacial growth has not been identified.the purpose of this study is to analyze a large, diverse cohort of patients with cleft lip and palate to determine whether timing of primary palate repair and primary lip repair co ...201728403023
sirt6 polymorphism rs117385980 is associated with longevity and healthy aging in finnish men.sirtuin-6 (sirt6) is involved in various crucial cellular pathways, being a key regulator of telomere structure, dna repair, metabolism, transcriptional control and the nf-kappa b pathway. sirt6 knock-out mice have been reported to develop typical features of aging and senescence at the age of 2-3 weeks and die within 4 weeks. the aim of this study was to investigate whether sequence variations of sirt6 are associated with aging and longevity in finnish men.201728399814
intrawound tobramycin powder eradicates surgical wound contamination: an in vivo rabbit study.therapeutic anti-infective trial in rabbitsobjective.: the purpose of the present study was to assess the efficacy of intrawound tobramycin powder in terms of eradicating a known bacterial contamination in an escherichia coli infected rabbit spinal implantation model.201728399544
incidence of le fort surgery in a mature cohort of patients with cleft lip and palate.primary repair of cleft lip and palate occurs early in life, but ideal timing of these interventions remains controversial. prior research has indicated that a later palate repair may improve patients' midfacial growth long term, whereas optimal timing of lip repair to maximize midfacial growth has not been identified.the purpose of this study is to analyze a large, diverse cohort of patients with cleft lip and palate to determine whether timing of primary palate repair and primary lip repair co ...201728399025
a case of atypical ophthalmoplegia after chikungunya fever.this study aims to report an unusual case of bilateral diffuse ophthalmoplegia with levator sparing, in a patient after an episode of chikungunya fever.201728397145
clear: composition of likelihoods for evolve and resequence experiments.the advent of next generation sequencing technologies has made whole-genome and whole-population sampling possible, even for eukaryotes with large genomes. with this development, experimental evolution studies can be designed to observe molecular evolution "in action" via evolve-and-resequence (e&r) experiments. among other applications, e&r studies can be used to locate the genes and variants responsible for genetic adaptation. most existing literature on time-series data analysis often assumes ...201728396506
risk factors for developing scoliosis in cerebral palsy: a cross-sectional descriptive study.this study aims to identify the risk factors leading to the development of severe scoliosis among children with cerebral palsy. a cross-sectional descriptive study of 70 children (aged 12-18 years) with severe spastic and/or dystonic cerebral palsy treated in a single specialist unit is described. statistical analysis included fisher exact test and logistic regression analysis to identify risk factors. severe scoliosis is more likely to occur in patients with intractable epilepsy ( p = .008), po ...201728395573
[antibody persistence following on different vaccination strategies of domestic measles, mumps and rubella combined attenuated live vaccine: a 3-year follow-up study].objective: to assess the 3-year antibody persistence after vaccination of domestic measles, mumps and rubella combined attenuated live vaccine (mmr) with different program. methods: children from three different vaccination strategies (group 8 m mr: 8 months and 18 months vaccinated with measles-rubella combined attenuated live vaccine and domestic mmr,respectively; group 8 m mmr: 8 months and 18 months both vaccinated with domestic mmr; group 12 m mmr: 12 months and 22 months both vaccinated wi ...201728395468
travellers' diarrhoea-a survey of practice.travellers' diarrhoea (td) is a common problem, affecting millions of tourists each year and creating a large economic burden. risk factors for td are known and guidelines exist to assist practitioners in advising travellers on how to prevent and treat td. however, data are lacking regarding actual prescribing practices or approaches used in td management. this study aims to establish a baseline which identifies uniformities and diversities in practice.201728395092
bovine serum albumin-glutaraldehyde (bioglue(®)) tissue adhesive versus standard renorrhaphy following renal mass enucleation: a retrospective comparison.to present the operative and post-operative comparison between patients who underwent tumor-bed closure with sutures compared with bovine serum albumin-glutaraldehyde (bioglue(®)) tissue sealant only.201728392835
comparison of ion personal genome machine platforms for the detection of variants in brca1 and brca2.transition to next generation sequencing (ngs) for brca1/brca2 analysis in clinical laboratories is ongoing but different platforms and/or data analysis pipelines give different results resulting in difficulties in implementation. we have evaluated the ion personal genome machine (pgm) platforms (ion pgm, ion pgm dx, thermo fisher scientific) for the analysis of brca1/2.201728392550
diagnostic accuracy of routine blood examinations and csf lactate level for post-neurosurgical bacterial meningitis.to evaluate the diagnostic accuracy of routine blood examinations and cerebrospinal fluid (csf) lactate level for post-neurosurgical bacterial meningitis (pbm) at a large sample-size of post-neurosurgical patients.201728392319
predicting posttraumatic hydrocephalus: derivation and validation of a risk scoring system based on clinical characteristics.posttraumatic hydrocephalus (pth) is a disorder of disturbed cerebrospinal fluid (csf) dynamics after traumatic brain injury (tbi). it can lead to brain metabolic impairment and dysfunction and has a high risk of clinical deterioration and worse outcomes. the incidence and risk factors for the development of pth after decompressive craniectomy (dc) has been assessed in previous studies, but rare studies identify patients with higher risk for pth among all tbi patients. this study aimed to develo ...201728391551
psychological profiles in patients with symptomatic reticular forms of oral lichen planus: a prospective cohort study.to analyze intra, extra-oral symptoms and psychological profiles in symptomatic patients with reticular (r) forms of oral lichen planus (olp).201728390063
effect of intravenous administration of contrast media on serum creatinine levels in neonates.purpose to assess the effect of intravenous contrast media on renal function in neonates. materials and methods institutional review board approval was obtained with waiver of consent. electronic health records from january 2011 to april 2013 were reviewed retrospectively. measures of renal function were obtained in inpatient neonates who underwent magnetic resonance (mr) imaging or computed tomography (ct) and for whom serum creatinine (cr) levels were obtained within 72 hours before imaging an ...201728387639
review of surgical techniques of experimental renal transplantation in rats.microvascular surgical techniques of renal transplant in rats have evolved over the past 5 decades to achieve successful rat renal transplant; these modifications have included surgical techniques to address the anatomic variations in the renal blood vessels and those to reduce ischemic and operation durations. here, we review the surgical techniques of renal transplant in rats and evaluate the advantages and disadvantages of individual techniques of vascular and ureteric anastomoses. for this r ...201728387172
effect of delayed onset prostacyclin on markers of endothelial function and damage after subarachnoid hemorrhage.subarachnoid hemorrhage (sah) is a neurological emergency. delayed ischemic neurological deficit is one of the main causes of poor outcome after sah and is probably caused, at least in part, by cerebral vasospasm. the pathophysiology of this is multifaceted, but endothelial damage and activation as well as glycocalyx damage have been implicated. prostacyclin has been shown to protect damaged and activated endothelium and to facilitate glycocalyx repair. we investigated biomarkers of endothelial ...201728386837
study of lung cancer regulatory network that involves erbb4 and tumor marker gene.our purpose is to screen out serum tumor markers closely correlated to the nature of solitary pulmonary nodule (spn) and to draw a regulatory network containing genes correlated to lung cancer. two hundred and sixty cases of spn patients confirmed through pathological diagnosis were collected as subjects, factors closely correlated to the nature of spn were screened out from eight tumor markers through fisher discriminant method, and functional annotation and pathway analysis were conducted on e ...201728386192
effect of repeated ceramic firings on the marginal and internal adaptation of metal ceramic restorations fabricated with different cad-cam technologies.the use of computer-aided design and computer-aided manufacturing (cad-cam) for metal ceramic restorations has increased with advances in the technology. however, little is known about the marginal and internal adaptation of restorations fabricated using laser sintering (ls) and soft milling (sm). moreover, the effects of repeated ceramic firings on the marginal and internal adaptation of metal ceramic restorations fabricated with ls and sm is also unknown.201728385435
mibg avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: a report from the children's oncology group.prior studies suggest that neuroblastomas that do not accumulate metaiodobenzylguanidine (mibg) on diagnostic imaging (mibg non-avid) may have more favorable features compared with mibg avid tumors. we compared clinical features, biologic features, and clinical outcomes between patients with mibg nonavid and mibg avid neuroblastoma.201728383813
the occurrence and persistence of thoughts of suicide, self-harm and death in family caregivers of people with dementia: a longitudinal data analysis over 2 years.family caregivers of people with dementia often report high levels of stress and depression, but little is known about those who contemplate suicide or self-harm. this study explores thoughts of suicide, self-harm and death in dementia caregivers and investigates the characteristics that distinguish them from those without such thoughts.201728379646
human health alters the sustainability of fishing practices in east africa.understanding feedbacks between human and environmental health is critical for the millions who cope with recurrent illness and rely directly on natural resources for sustenance. although studies have examined how environmental degradation exacerbates infectious disease, the effects of human health on our use of the environment remains unexplored. human illness is often tacitly assumed to reduce human impacts on the environment. by this logic, ill people reduce the time and effort that they put ...201728377522
assessing initial response to high-frequency jet ventilation in premature infants with hypercapnic respiratory failure.high-frequency jet ventilation (hfjv) has been used in conjunction with conventional ventilation for infants with respiratory failure. we sought to identify parameters that were associated with successful application of hfjv in patients with hypercapnic respiratory failure.201728377402
hypervitaminemia b12 and malignant diseases: report of a cross-sectional study in an acute geriatric unit.hypervitaminemia b12 has been associated or linked with a range of conditions, the majority of which are serious. between march 26(th), 2014 and june 30(th), 2014, all patients aged ≥65 years, hospitalized in an acute geriatric unit in the university hospital center of reims (france) were included in an observational study. 190 patients were included. 48 patients presented a hypervitaminemia b12 (25.3%). the gender ratio (m/f) of the population with elevated vitamin b12 levels was 0.5. 41 patien ...201728377332
association between an increase in blood urea nitrogen at 24 hours and worse outcomes in acute nonvariceal upper gi bleeding.an increase in blood urea nitrogen (bun) at 24 hours is a solitary and significant predictor of mortality in patients with acute pancreatitis, which may predict worse outcomes in the similarly resuscitation-requiring condition of acute nonvariceal upper gi bleeding (ugib). the aim of our study was to assess whether an increase in bun at 24 hours is predictive of worse clinical outcomes in acute nonvariceal ugib.201728377105
evaluation of skeletal muscle function in lung transplant candidates.lung transplantation (ltx) is offered to older and more complex patients who may be at higher risk of skeletal muscle dysfunction, but the clinical implications of this remain uncertain. the study aims were to characterize deficits in skeletal muscle mass, strength and physical performance, and examine the associations of these deficits with clinical outcomes.201728376036
oral therapy, microbiological findings, and comorbidity influence the outcome of prosthetic joint infections undergoing 2-stage exchange.the aim of the present study was to investigate potential predictive factors of an unfavorable outcome in patients with prosthetic joint infection (pji) undergoing 2-stage exchange.201728372916
the "wedge sign": an imaging sign for aggressive lacrimal gland disease.lacrimal gland carcinoma can form a triangle of tissue back to the orbital apex, intraconal spread apparently being prevented by the intermuscular septum. the "wedge sign" frequency is assessed in lacrimal carcinoma, lacrimal lymphoma, or dacryoadenitis.201728372859
excellent versus unacceptable orthodontic results: influencing factors.to retrospectively compare patients with excellent and unacceptable orthodontic treatment results with respect to possible prognostic factors.201728371839
does age impact on expectations and concerns of patients attending a chronic pain clinic?recognizing expectations and concerns of patients leads to more specialized management plans and greater adherence to treatment, and improves outcomes. little is known about how age impacts on expectations or concerns regarding pain in patients attending a chronic pain clinic.201728371046
historical spatial reconstruction of a spawning-aggregation fishery.aggregations of individual animals that form for breeding purposes are a critical ecological process for many species, yet these aggregations are inherently vulnerable to exploitation. studies of the decline of exploited populations that form breeding aggregations tend to focus on catch rate and thus often overlook reductions in geographic range. we tested the hypothesis that catch rate and site occupancy of exploited fish-spawning aggregations (fsas) decline in synchrony over time. we used the ...201728370319
the generation and validation of a 20-genes model influencing the prognosis of colorectal cancer.colorectal cancer is a common malignant tumor with high incidence affecting the digestive system. this study aimed to identify the key genes relating to prognosis of colorectal cancer and to construct a prognostic model for its risk evaluation. gene expression profiling of colorectal cancer patients, gse17537, was downloaded from gene expression omnibus database (geo). a total of 55 samples from patients ranging from stages 1 to 4 were available. differentially expressed genes were screened, wit ...201728370286
the pesticide dieldrin disrupts proteins related to oxidative respiration and mitochondrial stress in the central nervous system.quantitative proteins analysis was carried out in the hypothalamus of zebrafish following dietary exposure to the legacy pesticide dieldrin. data were collected using itraq labeling methodology and data were acquired using a hybrid quadrupole orbitrap (q exactive) ms system (thermo fisher scientific, bremen, germany). there were 3941 proteins identified in the hypothalamus of zebrafish, and these proteins comprised 23 unique expression patterns for proteins based on the three doses of dieldrin. ...201728367483
a case of miller fisher syndrome and literature review.miller fisher syndrome (mfs)  was first recognized by james collier in 1932 as a clinical triad of ataxia, areflexia, and ophthalmoplegia. later, it was described in 1956 by charles miller fisher as a possible variant of guillain-barré syndrome (gbs). here, we write a case of a patient with atypical presentation of this clinical triad as the patient presented with double vision initially due to unilateral ocular involvement that progressed to bilateral ophthalmoplegia. he developed weakness of t ...201728367386
improvement of voiding characteristics in morbidly obese women after bariatric surgery: a single-center study with a 1-year follow-up.it is well known that morbid obesity in women is related to lower urinary tract symptoms, including urinary incontinence. although several studies have reported on the improvement in urinary incontinence after bariatric surgery, few reports have focused on the detailed changes in other voiding characteristics.201728366670
ultra-early angiographic vasospasm after aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.after aneurysmal subarachnoid hemorrhage (asah), prognosis is affected heavily by the presence of delayed cerebral ischemia (dci). there is growing recognition of ultra-early angiographic vasospasm (ueav) occurring within 48 hours of asah; however, its relationship with dci and ultimately prognosis remains unclear.201728365434
quality of blood pressure measurement in community health centres.to determine the quality of the blood pressure measurements performed during routine care in community health centres.201728365207
genetic polymorphisms underlying the skeletal class iii phenotype.our goal was to verify the association between candidate polymorphisms and skeletal class iii malocclusion in a well-characterized homogeneous sample set.201728364893
a clustering-based approach for efficient identification of microrna combinatorial biomarkers.micrornas (mirnas) have great potential serving as tumor biomarkers and therapeutic targets. as the rapid development of high-throughput experimental technology, gene expression experiments have become more and more specialized and diversified. the complex data structure has brought great challenge for the identification of biomarkers. in the meantime, current statistical and machine learning methods for detecting biomarkers have the problem of low reliability and biased criteria.201728361698
[specific folic-acid targeted photosensitizer. the first step toward intraperitoneal photodynamic therapy for epithelial ovarian cancer].epithelial ovarian cancer (eoc) management remains association of debulking surgery in combination with platinum-based chemotherapy. sixty percent of women with eoc considered in remission will develop recurrent disease. an option to improve the completion of cytoreductive surgery may be the use of photodynamic therapy to induce necrosis of peritoneal metastases. a limit of this technique was the toxicity induced by the lack of specificity of old-generation photosensitizer (ps) for tumor tissue ...201728359805
bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer.epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (snps) of functional importance in cancer development. super-enhancers are cell-specific dna elements, acting to determine tissue or cell identity and driving tumor progression. although previous approaches have been tried to explain risk associated with snps in regulatory dna elements, so far epigenetic readers such as bromodomain containing protein 4 (brd4) and super-enhancers ha ...201728359301
early complications and associated perioperative factors in nonsyndromic craniosynostosis.this is the first eastern center-based retrospective report on early complications and associated perioperative factors of nonsyndromic craniosynostosis (nsc). the authors' purpose is to tailor preoperative counseling, convey objective perioperative data, and determinants for early complications in nsc so as to enhance exchanges with international center. inclusion criteria required a diagnosis of nsc confirmed by 3-dimentional computed tomography scans and complete medical record. genetic evide ...201728358766
low dimensional representation of fisher vectors for microscopy image classification.microscopy image classification is important in various biomedical applications, such as cancer subtype identification, and protein localization for high content screening. to achieve automated and effective microscopy image classification, the representative and discriminative capability of image feature descriptors is essential. to this end, in this paper, we propose a new feature representation algorithm to facilitate automated microscopy image classification. in particular, we incorporate fi ...201728358678
cognitive functioning, aging, and work: a review and recommendations for research and practice.there is a larger proportion and number of older adults in the labor force than ever before. furthermore, older adults in the workforce are working until later ages. although a great deal of research has examined physical health and well-being of working older adults, less research has focused on cognitive functioning. the purpose of this article is to provide a broad contemporary and multidisciplinary review of the intersection between cognitive functioning, aging, and work as a follow-up to a ...201728358568
causes of variability in prevalence rates of communicable diseases among secondary school students in kisumu county, kenya.to determine causes of variability in communicable disease prevalence rates among students in secondary schools to inform policy formulation in the public health sector.201728357195
screening of the filamin c gene in a large cohort of hypertrophic cardiomyopathy patients.recent exome sequencing studies identified filamin c (flnc) as a candidate gene for hypertrophic cardiomyopathy (hcm). our aim was to determine the rate of flnc candidate variants in a large cohort of hcm patients who were also sequenced for the main sarcomere genes.201728356264
[changes in nutritional status of patients with different diseases during hospitalization].objective: to evaluate changes in nutritional status of hospitalized patients with different diseases by subjective global assessment (sga) and nutritional risk screening (nrs-2002). methods: a prospective and parallel research done by multi-center collaboration from 34 hospitals in china from june to september 2014. hospitalized patients with the following diseases were investigated: malignant tumor (2 487 cases), benign disease of the digestive system (1 358 cases), benign disease of the nervo ...201728355769
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