Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| use of injectable hormonal contraception and women's risk of herpes simplex virus type 2 acquisition: a prospective study of couples in rakai, uganda. | the injectable hormonal contraceptive depo-medroxyprogesterone acetate (dmpa) has been associated with increased risk of hiv acquisition, but findings are inconsistent. whether dmpa increases the risk of other sexually transmitted viral infections is unknown. we assessed the association between dmpa use and incident herpes simplex virus type 2 (hsv2) infection in women. | 2015 | 26094162 |
| laboratory diagnosis and epidemiology of herpes simplex 1 and 2 genital infections. | herpes simplex virus types 1 and 2 are the main cause of genital ulcers worldwide. although herpes simplex virus type 2 is the major cause of genital lesions, herpes simplex virus type 1 accounts for half of new cases in developed countries. herpes simplex virus type 2 seroprevalence rises with sexual activity from adolescence through adulthood. slovenian data in a high-risk population shows 16% seroprevalence of hsv-2. hsv-1 and hsv-2 dna in genital swabs was detected in 19% and 20.7%, respecti ... | 2015 | 26086165 |
| male circumcision and sti acquisition in britain: evidence from a national probability sample survey. | it is well-established that male circumcision reduces acquisition of hiv, herpes simplex virus 2, chancroid, and syphilis. however, the effect on the acquisition of non-ulcerative sexually transmitted infections (stis) remains unclear. we examined the relationship between circumcision and biological measures of three stis: human papillomavirus (hpv), chlamydia trachomatis and mycoplasma genitalium. | 2015 | 26083250 |
| herpes viral origin of the parsonage-turner syndrome: highlighting of serological immune anti-herpes deficiency cured by anti-herpes therapy. | in 2012, a 50 year-old athletic male presented with weakness, pain and unilateral phrenic paralysis, followed by bilateral phrenic paralysis with deep dyspnea. in 2013, the parsonage-turner syndrome was diagnosed. when the patient was seen in september 2014 for the first time, he was facing phrenic neuromuscular failure, which led to the hypothesis of neurotropic herpes viruses. a control of the global serological anti-herpes immunity to analyze his antibody (ab) levels confirmed herpes immune g ... | 2017 | 26078744 |
| the incidence of trichomonas vaginalis infection in women attending nine sexually transmitted diseases clinics in the usa. | trichomoniasis (tv) is associated with an increased risk of acquisition of sexually transmitted diseases (stds) and hiv. the purpose of this study is to evaluate factors associated with incidence tv among female std clinic attendees in the usa. | 2016 | 26071390 |
| oral and vaginal tenofovir for genital herpes simplex virus type 2 shedding in immunocompetent women: a double-blind, randomized, cross-over trial. | tenofovir is a potent anti-human immunodeficiency virus (hiv) agent that decreased risk of herpes simplex virus type 2 (hsv-2) acquisition in hiv pre-exposure prophylaxis trials. whether tenofovir has utility in established hsv-2 disease is unclear. | 2015 | 26044291 |
| herpes simplex virus 1 reactivates from autonomic ciliary ganglia independently from sensory trigeminal ganglia to cause recurrent ocular disease. | herpes simplex virus 1 (hsv-1) and hsv-2 establish latency in sensory and autonomic neurons after ocular or genital infection, but their recurrence patterns differ. hsv-1 reactivates from latency to cause recurrent orofacial disease, and while hsv-1 also causes genital lesions, hsv-2 recurs more efficiently in the genital region and rarely causes ocular disease. the mechanisms regulating these anatomical preferences are unclear. to determine whether differences in latent infection and reactivati ... | 2015 | 26041294 |
| a dual-modality herpes simplex virus 2 vaccine for preventing genital herpes by using glycoprotein c and d subunit antigens to induce potent antibody responses and adenovirus vectors containing capsid and tegument proteins as t cell immunogens. | we evaluated a genital herpes prophylactic vaccine containing herpes simplex virus 2 (hsv-2) glycoproteins c (gc2) and d (gd2) to stimulate humoral immunity and ul19 (capsid protein vp5) and ul47 (tegument protein vp13/14) as t cell immunogens. the hsv-2 gc2 and gd2 proteins were expressed in baculovirus, while the ul19 and ul47 genes were expressed from replication-defective adenovirus vectors. adenovirus vectors containing ul19 and ul47 stimulated human and murine cd4(+) and cd8(+) t cell resp ... | 2015 | 26041292 |
| maternal exposure to sexually transmitted infections and schizophrenia among offspring. | animal models and epidemiologic studies suggest that prenatal maternal infection, and sexually transmitted infection (sti) in particular, is associated with an increased risk of schizophrenia in the offspring. however, findings from prior research studies on common infections, including herpes simplex virus type 2 (hsv-2) and chlamydia trachomatis (c. trachomatis) have been inconsistent. to investigate these associations, we conducted a case-control study nested in the population-based finnish p ... | 2015 | 26022653 |
| genome sequencing and analysis of geographically diverse clinical isolates of herpes simplex virus 2. | herpes simplex virus 2 (hsv-2), the principal causative agent of recurrent genital herpes, is a highly prevalent viral infection worldwide. limited information is available on the amount of genomic dna variation between hsv-2 strains because only two genomes have been determined, the hg52 laboratory strain and the newly sequenced sd90e low-passage-number clinical isolate strain, each from a different geographical area. in this study, we report the nearly complete genome sequences of 34 hsv-2 low ... | 2015 | 26018166 |
| global diversity within and between human herpesvirus 1 and 2 glycoproteins. | human herpes simplex viruses 1 and 2 (hsv-1 and hsv-2) are large-genome dna viruses that establish a persistent infection in sensory neurons and commonly manifest with recurring oral or genital erosions that transmit virus. hsv encodes 12 predicted glycoproteins that serve various functions, including cellular attachment, entry, and egress. glycoprotein g is currently the target of an antibody test to differentiate hsv-1 from hsv-2; however, this test has shown reduced capacity to differentiate ... | 2015 | 26018161 |
| vaginal douching and association with sexually transmitted infections among female sex workers in a prefecture of yunnan province, china. | summaryvaginal douching is a common practice and has been hypothesised to increase a woman's risk for human of contracting hiv and sexually transmitted infections (stis). our objective was to assess the prevalence of douching and its association with stis, genital symptoms and hiv/sti knowledge among female sex workers (fsws). we conducted a cross-sectional study of 837 fsws with interviews and laboratory tests for hiv/stis in a prefecture of yunnan province in southern china. vaginal douching w ... | 2016 | 26016725 |
| evaluating hiv prevention programs: herpes simplex virus type 2 antibodies as biomarker for sexual risk behavior in young adults in resource-poor countries. | measuring effectiveness of hiv prevention interventions is challenged by bias when using self-reported knowledge, attitude or behavior change. hiv incidence is an objective marker to measure effectiveness of hiv prevention interventions, however, because new infection rates are relatively low, prevention studies require large sample sizes. herpes simplex virus type 2 (hsv-2) is similarly transmitted and more prevalent and could thus serve as a proxy marker for sexual risk behavior and therefore ... | 2015 | 26010772 |
| partial and total c-6 oxidation of gelling carrageenans. modulation of the antiviral activity with the anionic character. | the optimal conditions for the full c-6 oxidation of κ- and ι-carrageenans using (2,2,6,6-tetramethylpiperidinyl)oxy (tempo) in the presence of sodium hypochlorite and sodium bromide were assessed. the fully oxidized products were characterized by nmr spectroscopy. partially oxidized products were also obtained and analyzed by chemical and spectroscopical methods. the antiviral activity of carrageenans against herpes simplex virus hsv-1 and hsv-2 determined by plaque reduction assay, was not lar ... | 2015 | 26005156 |
| variability of human immunodeficiency virus-1 in the female genital reservoir during genital reactivation of herpes simplex virus type 2. | clinical and subclinical genital herpes simplex virus type 2 (hsv-2) reactivations have been associated with increases in human immunodeficiency virus (hiv)-1 genital shedding. whether hsv-2 shedding contributes to the selection of specific genital hiv-1 variants remains unknown. we evaluated the genetic diversity of genital and blood hiv-1 rna and dna in 14 hiv-1/hsv-2-co-infected women, including seven with hsv-2 genital reactivation, and seven without as controls. hiv-1 dna and hiv-1 rna env ... | 2015 | 26003280 |
| application of mccoy cell line for propagation of herpes simplex virus type 1. | herpes simplex virus types 1 (hsv-1) and 2 (hsv-2) are members of the herpesviridae family. about 40% to 80% of the world populations are infected with hsv and its prevalence is high in iran. the high prevalence of this virus in the community and the ability of the virus in causing fatal diseases among immunocompromised patients, have encouraged studies to be performed on hsv and suitable cell lines which supports the propagation of hsv. the aim of this study was to evaluate the suitability of m ... | 2015 | 25999628 |
| immunization with hsv-2 gb-ccl19 fusion constructs protects mice against lethal vaginal challenge. | there is a lack of an hsv-2 vaccine, in part as the result of various factors that limit robust and long-term memory immune responses at the mucosal portals of viral entry. we previously demonstrated that chemokine ccl19 augmented mucosal and systemic immune responses to hiv-1 envelope glycoprotein. whether such enhanced immunity can protect animals against virus infection remains to be addressed. we hypothesized that using ccl19 in a fusion form to direct an immunogen to responsive immunocytes ... | 2015 | 25994965 |
| correction: global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012. | 2015 | 25992922 | |
| almond skin inhibits hsv-2 replication in peripheral blood mononuclear cells by modulating the cytokine network. | we have investigated the effect of almond skin extracts on the production of pro-inflammatory and anti-inflammatory cytokines in human peripheral blood mononuclear cells (pbmcs). pbmcs were either infected or not by herpes simplex virus type 2 (hsv-2), with and without prior treatment with almond skin extracts. production of il-17 induced by hsv-2 was inhibited by natural skins (ns) treatment. ns triggered pbmc in releasing ifn-α, ifn-γ and il-4 in cellular supernatants. these results may explai ... | 2015 | 25988612 |
| obstetric outcomes of human herpes virus-2 infection among pregnant women in benin, nigeria. | this study investigated the obstetric outcomes of herpes simplex virus (hsv-2) infection among pregnant women. | 2015 | 25966714 |
| upstream binding factor inhibits herpes simplex virus replication. | herpes simplex virus 1 (hsv-1) infection induces changes to the host cell nucleus including relocalization of the cellular protein upstream binding factor (ubf) from the nucleolus to viral replication compartments (vrcs). herein, we tested the hypothesis that ubf is recruited to vrcs to promote viral dna replication. surprisingly, infection of ubf-depleted hela cells with hsv-1 or hsv-2 produced higher viral titers compared to controls. reduced expression of ubf also led to a progressive increas ... | 2015 | 25965800 |
| contribution of n-linked glycans on hsv-2 gb to cell-cell fusion and viral entry. | hsv-2 is the major cause of genital herpes and its infection increases the risk of hiv-1 acquisition and transmission. hsv-2 glycoprotein b together with glycoproteins d, h and l are indispensable for viral entry, of which gb, as a class iii fusogen, plays an essential role. hsv-2 gb has seven potential n-linked glycosylation (n-cho) sites, but their significance has yet to be determined. for the first time, we systematically analyzed the contributions of n-linked glycans on gb to cell-cell fusi ... | 2015 | 25965797 |
| prevalence and correlates of trichomonas vaginalis infection among female sex workers in a city in yunnan province, china. | sexual transmission is the fastest growing route of hiv transmission in china, and trichomonas vaginalis(tv) can facilitate hiv transmission and acquisition. our goal was to determine the prevalence and correlates of tv infection among female sex workers (fsws). this cross-sectional study was conducted in a city of yunnan province in southern china, with confidential face-to-face interviews and laboratory tests for tv (wet mount) and other sexually transmitted infections. a total of 734 fsws par ... | 2016 | 25957327 |
| club drugs and hiv/std infection: an exploratory analysis among men who have sex with men in changsha, china. | to evaluate current club drug use and its potential association with the transmission of hiv/std among changsha men who have sex with men (msm). | 2015 | 25950912 |
| large-scale multiplex polymerase chain reaction assay for diagnosis of viral reactivations after allogeneic hematopoietic stem cell transplantation. | viral reactivations following hematopoietic stem cell transplantation are thought to result from the breakdown of both cell-mediated and humoral immunity. as a result, many viruses could be reactivated individually or simultaneously. using a multiplex polymerase chain reaction (pcr), we prospectively examined many kinds of viral dnas at a time in 105 patients who underwent allogeneic hematopoietic stem cell transplantation. in total, 591 whole blood samples were collected weekly from pre- to 42 ... | 2015 | 25946433 |
| herpes simplex [corrected] virus type 2 shedding from male circumcision wounds in rakai, uganda. | a prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (hsv-2) was conducted to assess whether their sexual partners may be at an increased risk of hsv-2 from male circumcision (mc) wounds. preoperative and weekly penile lavage samples were tested for penile hsv-2 shedding. prevalence risk ratios (prrs) were estimated using poisson regression. detectable penile hsv-2 shedding was present in 9.7% of men (17 of 176) before mc, comp ... | 2015 | 25943201 |
| socio-demographic and behavioural characteristics associated with hsv-2 sero-prevalence in high risk women in kwazulu-natal. | the world health organization estimates that 536 million people aged 15-49 are infected with herpes simplex virus type 2 (hsv-2), the causative agent of genital herpes. the aim of this study was to investigate the role of behavioral and demographic factors that contribute to the high hsv-2 sero-prevalence among women participating in a hiv prevention trial. the methods for improving reproductive health in africa (mira) study assessed the effectiveness the latex diaphragm and lubricant gel on hiv ... | 2015 | 25940115 |
| the immunomodulator, ammonium trichloro[1,2-ethanediolato-o,o']-tellurate, suppresses the propagation of herpes simplex virus 2 by reducing the infectivity of the virus progeny. | persistent investigations for the identification of novel anti-herpetic drugs are being conducted worldwide, as current treatment options are sometimes insufficient. the immunomodulator, ammonium trichloro[1,2‑ethanediolato‑o,o']‑tellurate (as101), a non‑toxic tellurium (ⅳ) compound, has been shown to exhibit anti‑viral activity against a variety of viruses in cell cultures and in animal models. in the present study, the anti‑viral activity of as101 against herpes simplex virus (hsv)‑1 and 2 was ... | 2015 | 25936393 |
| acute retinal necrosis secondary to herpes simplex virus type 2 in neonates. | acute retinal necrosis (arn) should be in the differential diagnosis of a neonate who presents with vitritis. this report includes three cases of neonatal arn at the bascom palmer eye institute from 2004 to 2009. medical treatment with acyclovir helped reduce sequelae of herpes simplex virus (hsv) 2 infection. patients with arn are at risk for retinal detachment and blindness. although mothers are screened during pregnancy, they are at risk of reactivation or primary contraction of hsv. a neonat ... | 2015 | 25932732 |
| risk behaviours and prevalence of sexually transmitted infections and hiv in a group of dominican gay men, other men who have sex with men and transgender women. | the objectives of this study were to estimate the point prevalence of sexually transmitted infection (sti) and to investigate the sexual practices and behaviours associated with stis in a group of gay men, other men who have sex with men and transgender women (gmt) in the province of la romana, dominican republic. | 2015 | 25926151 |
| evasion of early antiviral responses by herpes simplex viruses. | besides overcoming physical constraints, such as extreme temperatures, reduced humidity, elevated pressure, and natural predators, human pathogens further need to overcome an arsenal of antimicrobial components evolved by the host to limit infection, replication and optimally, reinfection. herpes simplex virus-1 (hsv-1) and herpes simplex virus-2 (hsv-2) infect humans at a high frequency and persist within the host for life by establishing latency in neurons. to gain access to these cells, herpe ... | 2015 | 25918478 |
| evaluating the performance of the focus herpeselect® hsv-2 igg in veterans with chronic hepatitis c infection. | epidemiologic links between chronic hepatitis c and herpes simplex type-2 infection have been suggested; however, type-specific tests for hsv-2 infection have not been validated in patients with chronic hepatitis c infection. the focus herpeselect(®) hsv-2 igg (cypress, california) assay and the biokit hsv-2 rapid assay (biokit usa, lexington, ma) were performed on serum samples obtained from 84 veterans with chronic hepatitis c who demonstrated a previously positive hsv-2 serologic test in thei ... | 2015 | 25908332 |
| overexpression and purification of hsv-2 glycoprotein d in suspension cho cells with serum-free medium and immunogenicity analysis. | glycoprotein d (gd2) is the most important candidate antigen for herpes simplex virus type 2 (hsv-2) vaccine development. establishment of a stable eukaryotic cell line to overexpress gd2 and an efficient purification process to purify is essential for the development of subunit vaccine against hsv-2. the dna sequence of the extracellular epitope-rich fragment of gd2 was optimized, chemically synthesized, and cloned into plasmid pmd902. the recombinant plasmid pmd902-gd was stably transfected in ... | 2016 | 25906680 |
| programming the composition of polymer blend particles for controlled immunity towards individual protein antigens. | in order for a more precise control over the quality and quantity of immune responses stimulated by synthetic particle-based vaccines, it is critical to control the colloidal stability of particles and the release of protein antigens in both extracellular space and intracellular compartments. different proteins exhibit different sizes, charges and solubilities. this study focused on modulating the release and colloidal stability of proteins with varied isoelectric points. a polymer particle deli ... | 2015 | 25902361 |
| a spiroketal-enol ether derivative from tanacetum vulgare selectively inhibits hsv-1 and hsv-2 glycoprotein accumulation in vero cells. | the inhibitory effects of tanacetum vulgare rhizome extracts on hsv-1 and hsv-2 in vitro replication were assessed. unlike extracts obtained from the aerial parts, adsorption inhibition and virucidal activities seemed not to be relevant for the observed antiviral action of tansy rhizome extracts. instead, the most significant effects were the inhibition of virus penetration and a novel mechanism consisting of the specific arrest of viral gene expression and consequently the decrease of viral pro ... | 2015 | 25882624 |
| synergistic effects of acyclovir and 3, 19-isopropylideneandrographolide on herpes simplex virus wild types and drug-resistant strains. | an andrographolide analogue, 3, 19-isopropylideneandrographolide (ipad), exerts an inhibitory effect on replication of wild-type herpes simplex virus serotype 1 (hsv-1). in this study, we examined the anti-viral activity of ipad on hsv wild types (hsv-1 strain kos and hsv-2 clinical isolate) and hsv-1 drug-resistant strains (drs). synergistic effects of ipad with acyclovir (acv) were also evaluated. | 2015 | 25879785 |
| development and validation of a laboratory-developed multiplex real-time pcr assay on the bd max system for detection of herpes simplex virus and varicella-zoster virus dna in various clinical specimens. | a multiplex real-time pcr (quantitative pcr [qpcr]) assay detecting herpes simplex virus (hsv) and varicella-zoster virus (vzv) dna together with an internal control was developed on the bd max platform combining automated dna extraction and an open amplification procedure. its performance was compared to those of pcr assays routinely used in the laboratory, namely, a laboratory-developed test for hsv dna on the lightcycler instrument and a test using a commercial master mix for vzv dna on the a ... | 2015 | 25878344 |
| dynasore disrupts trafficking of herpes simplex virus proteins. | dynasore, a small-molecule inhibitor of the gtpase activity of dynamin, inhibits the entry of several viruses, including herpes simplex virus (hsv), but its impact on other steps in the viral life cycle has not been delineated. the current study was designed to test the hypothesis that dynamin is required for viral protein trafficking and thus has pleiotropic inhibitory effects on hsv infection. dynasore inhibited hsv-1 and hsv-2 infection of human epithelial and neuronal cells, including primar ... | 2015 | 25878109 |
| relationship between community-level alcohol outlet accessibility and individual-level herpes simplex virus type 2 infection among young women in south africa. | exposure to alcohol outlets may influence sexual health outcomes at the individual and community levels. visiting alcohol outlets facilitates alcohol consumption and exposes patrons to a risky environment and network of potential partners, whereas the presence of alcohol outlets in the community may shift social acceptance of riskier behavior. we hypothesize that living in communities with more alcohol outlets is associated with increased sexual risk. | 2015 | 25868138 |
| seroprevalence and seroincidence of herpes simplex virus (2006-2010), syphilis (2006-2010), and vaccine-preventable human papillomavirus subtypes (2000-2010) among us military personnel. | sexually transmitted infections have historically been burdensome in military populations. we describe the seroprevalence and seroincidence of vaccine-preventable human papillomavirus (vp-hpv) subtypes in a sample of 200 servicemen, along with the seroprevalence and seroincidence of herpes simplex virus (hsv-1/2) and syphilis in a sample of 200 men and 200 women. | 2015 | 25868137 |
| reactivation of herpes simplex type 1 in pneumococcal meningitis. | acute bacterial meningitis (abm) and herpes simplex type 1 (hsv-1) encephalitis are two rare but serious infections affecting the central nervous system (cns). concurrent bacterial and viral cns infection has occasionally been reported. | 2015 | 25866347 |
| genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains. | herpes simplex virus 2 (hsv-2) is a major global pathogen, infecting 16% of people 15 to 49 years old worldwide and causing recurrent genital ulcers. little is known about viral factors contributing to virulence, and there are currently only two genomic sequences available. in this study, we determined nearly complete genomic sequences of six additional hsv-2 isolates, using illumina miseq. we report that hsv-2 has a genomic overall mean distance of 0.2355%, which is less than that of hsv-1. the ... | 2015 | 25855744 |
| hiv blocks interferon induction in human dendritic cells and macrophages by dysregulation of tbk1. | dendritic cells (dcs) and macrophages are present in the tissues of the anogenital tract, where hiv-1 transmission occurs in almost all cases. these cells are both target cells for hiv-1 and represent the first opportunity for the virus to interfere with innate recognition. previously we have shown that both cell types fail to produce type i interferons (ifns) in response to hiv-1 but that, unlike t cells, the virus does not block ifn induction by targeting ifn regulatory factor 3 (irf3) for cel ... | 2015 | 25855743 |
| genital herpes: oral antiviral treatments. | genital herpes is an infection with herpes simplex virus type 1 (hsv-1) or type 2 (hsv-2), and is among the most common sexually transmitted diseases. | 2015 | 25853497 |
| high hiv prevalence and incidence among msm across 12 cities in india. | to characterize prevalence, incidence, and associated correlates of hiv infection among msm in 12 cities across india. | 2015 | 25849835 |
| rapid detection of active human cytomegalovirus infection in pregnancy using loop-mediated isothermal amplification. | understanding the association between congenital human cytomegalovirus (hcmv) infection and active maternal hcmv infection during pregnancy is important for maternal and neonatal healthcare. in the present study, a loop-mediated isothermal amplification (lamp) method was established for the detection of cmv dna from whole blood or amniotic fluid samples, using reverse transcription-quantitative polymerase chain reaction. the results of the present study demonstrated that the cmv lamp assay detec ... | 2015 | 25847382 |
| [ocular hypertension in herpes simplex keratouveitis]. | the herpes simplex virus is one of the most common pathogens in humans, who are seropositive for the virus in 90% of the cases at the adult age. it determines reccurent infections in more than a third of the population and these infections depend on the immune response of the host. ocular infections of newborns are due to the herpes simplex virus type 2, meanwhile type 1 is found predominantly at adults; almost all ocular structures can be affected. hsv-1 in the most frequent etiologic agent in ... | 2014 | 25842621 |
| herpes simplex virus type 2-infected dendritic cells produce tnf-α, which enhances ccr5 expression and stimulates hiv production from adjacent infected cells. | prior hsv-2 infection enhances the acquisition of hiv-1 >3-fold. in genital herpes lesions, the superficial layers of stratified squamous epithelium are disrupted, allowing easier access of hiv-1 to langerhans cells (lc) in the epidermis and perhaps even dendritic cells (dcs) in the outer dermis, as well as to lesion infiltrating activated t lymphocytes and macrophages. therefore, we examined the effects of coinfection with hiv-1 and hsv-2 on monocyte-derived dcs (mddc). with simultaneous coinfe ... | 2015 | 25840914 |
| immunogenicity, protective efficacy, and non-replicative status of the hsv-2 vaccine candidate hsv529 in mice and guinea pigs. | hsv-2 vaccine is needed to prevent genital disease, latent infection, and virus transmission. a replication-deficient mutant virus (dl5-29) has demonstrated promising efficacy in animal models of genital herpes. however, the immunogenicity, protective efficacy, and non-replicative status of the highly purified clinical vaccine candidate (hsv529) derived from dl5-29 have not been evaluated. humoral and cellular immune responses were measured in mice and guinea pigs immunized with hsv529. protecti ... | 2015 | 25837802 |
| sero-prevalence of herpes simplex type 2 virus (hsv-2) and hiv infection in kampala, uganda. | prevalence of herpes simplex type 2 virus (hsv-2) is high worldwide. previous studies in uganda were rural or in women. we estimated age and sex-specific sero-prevalence of hsv-2 in kampala, uganda. | 2014 | 25834483 |
| high prevalence of sexually transmitted infections in pregnant adolescent girls in tanzania: a multi-community cross-sectional study. | limited data document sexually transmitted infections (stis) among pregnant adolescents in sub-saharan africa, where prenatal screening typically includes only hiv and syphilis. given that hiv incidence in this population is among the world's highest, we sought to assess the prevalence and factors associated with stis in a population of rural pregnant adolescents in tanzania. | 2015 | 25834122 |
| manipulation of apoptosis and necroptosis signaling by herpesviruses. | like apoptosis, necroptosis is an innate immune mechanism that eliminates pathogen-infected cells. receptor-interacting protein kinase (rip)3 (also called ripk3) mediates necrotic death by phosphorylating an executioner protein, mlkl, leading to plasma membrane leakage. the pathway is triggered against viruses that block caspase 8. in murine cmv, the viral inhibitor of caspase 8 activation prevents extrinsic apoptosis but also has the potential to unleash necroptosis. this virus encodes the vira ... | 2015 | 25828583 |
| necroptosis: the trojan horse in cell autonomous antiviral host defense. | herpesviruses suppress cell death to assure sustained infection in their natural hosts. murine cytomegalovirus (mcmv) encodes suppressors of apoptosis as well as m45-encoded viral inhibitor of rip activation (vira) to block rip homotypic interaction motif (rhim)-signaling and recruitment of rip3 (also called ripk3), to prevent necroptosis. mcmv and human cytomegalovirus encode a viral inhibitor of caspase (casp)8 activation to block apoptosis, an activity that unleashes necroptosis. herpes simpl ... | 2015 | 25819165 |
| the effect of menopause on the innate antiviral activity of cervicovaginal lavage. | reproductive hormones are known to impact innate mucosal immune function of the lower genital tract. our objectives were to determine the effect of hormonal status on intrinsic antiviral (herpes simplex virus [hsv]-1, hsv-2, and human immunodeficiency virus [hiv]-1) activity of cervicovaginal lavage (cvl). | 2015 | 25818668 |
| renal allograft re-use and herpetic re-infection. | a middle-aged man received a kidney transplant from a deceased multi-organ donor. the recipient suffered cardiac arrest several days post-operatively and sustained hypoxic brain injury and was declared brain dead. following the family's consent, the allograft kidney was retrieved and re-transplanted into a man with end-stage renal failure secondary to reflux nephropathy. the liver was not transplanted due to suspicion of fatty changes based on macroscopic appearance. after transplantation of oth ... | 2015 | 25807853 |
| coping strategies and behavioural changes following a genital herpes diagnosis among an urban sample of underserved midwestern women. | this study focused on understanding the coping strategies and related behavioural changes of women who were recently diagnosed with herpes simplex virus type 2. in particular, we were interested in how coping strategies, condom use, and acyclovir uptake evolve over time. twenty-eight women screening positive for herpes simplex virus type 2 were recruited through a public health std clinic and the indianapolis community court. participants completed three semi-structured interviews with a woman r ... | 2016 | 25792549 |
| in vitro evaluation of the antiviral properties of shilajit and investigation of its mechanisms of action. | shilajit, a herbomineral substance exuded from rocks in steep mountainous regions, has been used for thousands of years by the indian ayurvedic and siddha systems of traditional medicine to relieve ailments and enhance quality of life. although a large number of therapeutic properties have been ascribed to shilajit, its therapeutic potential is still largely unexplored by modern research and many of its claimed bioactivities lack scientific validation. the present study was undertaken to investi ... | 2015 | 25792012 |
| laboratory-confirmed hiv and sexually transmitted infection seropositivity and risk behavior among sexually active transgender patients at an adolescent and young adult urban community health center. | the sexual health of transgender adolescents and young adults who present for health care in urban community health centers is understudied. a retrospective review of electronic health record (ehr) data was conducted from 180 transgender patients aged 12-29 years seen for one or more health-care visits between 2001 and 2010 at an urban community health center serving youth in boston, ma. analyses were restricted to 145 sexually active transgender youth (87.3% of the sample). laboratory-confirmed ... | 2015 | 25790139 |
| intravaginal rings: controlled release systems for contraception and prevention of transmission of sexually transmitted infections. | intravaginal rings (ivrs) are a dosage form used to locally or systemically deliver drugs in the vagina. they are capable of releasing one or more drugs over an extended period of time (from several weeks to a year or longer). contraceptive ivrs are currently gaining popularity due to the success of the contraceptive product nuvaring®. delivery of contraceptives from ivrs should promote compliance/adherence, and they also provide effective cycle control and symptom relief (menorrhagia, dysmenorr ... | 2011 | 25788239 |
| chemokine-mediated immune responses in the female genital tract mucosa. | the genital tract mucosa is the site where sexually transmitted infections gain entry to the host. the immune response at this site is thus critical to provide innate protection against pathogens that are seen for the very first time as well as provide long-term pathogen-specific immunity, which would be required for an effective vaccine against sexually transmitted infection. a finely regulated immune response is therefore required to provide an effective barrier against pathogens without compr ... | 2015 | 25776842 |
| evaluation of a viral microarray based on simultaneous extraction and amplification of viral nucleotide acid for detecting human herpesviruses and enteroviruses. | in this study, a viral microarray based assay was developed to detect the human herpesviruses and enteroviruses associated with central nervous system infections, including herpes simplex virus type 1, type 2 (hsv1 and hsv2), epstein-barr virus (ebv), cytomegalovirus (cmv), enterovirus 71 (ev71), coxsackievirus a 16 (ca16) and b 5(cb5). the dna polymerase gene of human herpesviruses and 5'-untranslated region of enteroviruses were selected as the targets to design primers and probes. human herpe ... | 2015 | 25774509 |
| isoxanthohumol--biologically active hop flavonoid. | isoxanthohumol (ixn), apart from xanthohumol (xn) and 8-prenylnaringenin (8pn), is one of the most important prenylflavonoids found in hops. another natural source of this compound is a shrub sophora flavescens, used in traditional chinese medicine. main dietary source of ixn is beer, and the compound is produced from xn during wort boiling. in the human body, the compound is o-demethylated to 8pn, the strongest known phytoestrogen. this process takes place in the liver and in the intestine, whe ... | 2015 | 25771121 |
| herpes simplex virus type 2 (hsv-2) genital shedding in hsv-2-/hiv-1-co-infected women receiving effective combination antiretroviral therapy. | the dynamics of genital shedding of hsv-2 dna was assessed in hiv-1-infected women taking combination antiretroviral therapy (cart). hiv-1 rna, hiv-1 dna and hsv dna loads were measured during 12-18 months using frozen plasma, pbmc and cervicovaginal lavage samples from 22 hiv-1-infected women, including 17 women naive for antiretroviral therapy initiating cart and 5 women with virological failure switching to a new regimen. nineteen (86%) women were hsv-2-seropositive. among hsv-2-/hiv-1-co-inf ... | 2016 | 25769886 |
| multipurpose prevention technologies: the future of hiv and sti protection. | every day, more than 1 million people are newly infected with sexually transmitted infections (stis) that can lead to morbidity, mortality, and an increased risk of human immunodeficiency virus (hiv) acquisition. existing prevention and management strategies, including behavior change, condom promotion, and therapy have not reduced the global incidence and prevalence, pointing to the need for novel innovative strategies. this review summarizes important issues raised during a satellite session a ... | 2015 | 25759332 |
| ups and downs in the search for a herpes simplex virus vaccine. | modified herpes simplex viruses that are unable to produce glycoprotein d may make effective vaccines. | 2015 | 25756748 |
| herpes simplex type 2 virus deleted in glycoprotein d protects against vaginal, skin and neural disease. | subunit vaccines comprised of glycoprotein d (gd-2) failed to prevent hsv-2 highlighting need for novel strategies. to test the hypothesis that deletion of gd-2 unmasks protective antigens, we evaluated the efficacy and safety of an hsv-2 virus deleted in gd-2 and complemented allowing a single round of replication on cells expressing hsv-1 gd (δgd(-/+gd-1)). subcutaneous immunization of c57bl/6 or balb/c mice with δgd(-/+gd1) provided 100% protection against lethal intravaginal or skin challeng ... | 2015 | 25756612 |
| vaginal lactobacillus gasseri cmul57 can inhibit herpes simplex type 2 but not coxsackievirus b4e2. | this study aimed at demonstrating the antiviral activity of lactobacillus gasseri cmul57 (l. gasseri cmul57), l. acidophilus cmul67 and l. plantarum cmul140 against herpes simplex type 2 (hsv-2) and coxsackievirus b4e2 (cvb4e2), which are enveloped and naked viruses, respectively. these lactobacilli were non-cytotoxic and were able to reduce the cytopathic effect induced by hsv-2 in vero cell monolayers. however, lactobacilli were not active against cvb4e2. tested lactobacilli displayed anti-hsv ... | 2015 | 25752765 |
| presumed bilateral acute retinal necrosis 11 years apart, atypical presentation, and early vitrectomy. | to report a case of presumed bilateral acute retinal necrosis with delayed onset caused by herpes simplex virus type 2, medical treatment, and surgical approach. | 2015 | 25743780 |
| vaginal cytomegalovirus shedding before and after initiation of antiretroviral therapy in rakai, uganda. | vaginal shedding of cytomegalovirus (cmv) dna was determined longitudinally among 96 women coinfected with human immunodeficiency virus (hiv), herpes simplex virus 2, and cmv starting antiretroviral therapy (art) during a placebo-controlled trial of hsv-2 suppression with acyclovir in rakai, uganda. vaginal cmv was detected in 75 of 96 women (78.0%) and 379 of 1080 individual visits (35.1%). art status, higher hiv rna viral load before art initiation, and younger age were significantly associate ... | 2015 | 25743428 |
| valacyclovir decreases plasma hiv-1 rna in hsv-2 seronegative individuals: a randomized placebo-controlled crossover trial. | acyclovir (acv), a highly specific anti-herpetic drug, acts as a dna chain terminator for several human herpesviruses (hhvs), including hhv-2 (hsv-2), a common human immunodeficiency virus (hiv)-1 co-pathogen. several trials demonstrated that hsv-2 suppressive therapy using acv or its prodrug valacyclovir (valacv) reduced plasma hiv-1 viral load (vl) in hiv-1/hsv-2 coinfected persons, and this was proposed to be due to a decrease in generalized immune activation. recently, however, we found that ... | 2015 | 25740794 |
| incidence of herpes simplex virus type 2 infections in africa: a systematic review. | the burden of hsv type 2 varies substantially by region, with the highest incidence and prevalence in sub-saharan africa. we undertook a systematic review to identify studies reporting prospective data on incidence rates in men and women in africa. of 18 eligible studies, 7 were conducted in high-risk populations. among women, incidence rates appeared to be higher in those with high-risk sexual behavior, with rates ranging from 3 to 23 per 100 person-years. in contrast, incidence rates in men ap ... | 2014 | 25734115 |
| prevalence of sexually transmitted infections including hiv in street-connected adolescents in western kenya. | the objectives of this study were to characterise the sexual health of street-connected adolescents in eldoret, kenya, analyse gender disparity of risks, estimate the prevalence of sexually transmitted infections (stis), and identify factors associated with stis. | 2015 | 25714102 |
| hsv-2 immediate-early protein us1 inhibits ifn-β production by suppressing association of irf-3 with ifn-β promoter. | hsv-2 is the major cause of genital herpes, and its infection increases the risk of hiv-1 acquisition and transmission. after initial infection, hsv-2 can establish latency within the nervous system and thus maintains lifelong infection in humans. it has been suggested that hsv-2 can inhibit type i ifn signaling, but the underlying mechanism has yet to be determined. in this study, we demonstrate that productive hsv-2 infection suppresses sendai virus (sev) or polyinosinic-polycytidylic acid-ind ... | 2015 | 25712217 |
| novel rat models to study primary genital herpes simplex virus-2 infection. | in this study we describe that six rat models (sd, wist, lew, bn, f344 and da) are susceptible to intravaginal herpes simplex virus-2 (hsv-2) infection after pre-treatment with progesterone. at a virus dose of 5 × 10(6) pfu of hsv-2, all rat models were infected presenting anti-hsv-2 antibodies, infectious virus in vaginal washes, and hsv-2 dna genome copies in lumbosacral dorsal root ganglia and the spinal cord. most of the lew, bn, f344, and da rats succumbed in systemic progressive symptoms a ... | 2015 | 25701211 |
| comparable mrna expression of inflammatory markers but lower claudin-1 mrna levels in foreskin tissue of hsv-2 seropositive versus seronegative asymptomatic kenyan young men. | skin biopsies from local sites of herpes simplex virus 2 (hsv-2)-induced ulcers can show infiltrates of inflammatory cells several months after macroscopic healing. we hypothesise that foreskin tissue samples of asymptomatic hsv-2 seropositive men had remaining signs of inflammation at the molecular level. even in the absence of clinical lesions, genital inflammation may contribute to increased hiv susceptibility on sexual exposure to the virus. | 2015 | 25694458 |
| neonatal herpes simplex virus infection: epidemiology and treatment. | herpes simplex virus types 1 (hsv-1) and 2 (hsv-2) are highly prevalent viruses capable of establishing lifelong infection. genital herpes in women of childbearing age represents a major risk for mother-to-child transmission (mtct) of hsv infection, with primary and first-episode genital hsv infections posing the highest risk. the advent of antiviral therapy with parenteral acyclovir has led to significant improvement in neonatal hsv disease mortality. further studies are needed to improve the c ... | 2015 | 25677996 |
| herpes simplex virus suppresses necroptosis in human cells. | herpes simplex virus (hsv)-1 and hsv-2 are significant human pathogens causing recurrent disease. during infection, hsv modulates cell death pathways using the large subunit (r1) of ribonucleotide reductase (rr) to suppress apoptosis by binding to and blocking caspase-8. here, we demonstrate that hsv-1 and hsv-2 r1 proteins (icp6 and icp10, respectively) also prevent necroptosis in human cells by inhibiting the interaction between receptor-interacting protein kinase 1 (rip1) and rip3, a key step ... | 2015 | 25674983 |
| characterization of herpes simplex virus 2 primary microrna transcript regulation. | in order to understand factors that may influence latency-associated transcription and latency-associated transcript (lat) phenotypes, we studied the expression of the herpes simplex virus 2 (hsv-2) lat-associated micrornas (mirnas). we mapped the transcription initiation sites of all three primary mirna transcripts and identified the icp4-binding sequences at the transcription initiation sites of both hsv-2 lat (pri-mirna for mir-i and mir-ii, which target icp34.5, and mir-iii, which targets ic ... | 2015 | 25673716 |
| the impact of hormonal contraception and pregnancy on sexually transmitted infections and on cervicovaginal microbiota in african sex workers. | the observed association between depo-provera injectable use and increased hiv acquisition may be caused by hormone-induced increased susceptibility to other sexually transmitted infections (stis) or changes in the cervicovaginal microbiota (vmb), accompanied by genital immune activation and/or mucosal remodeling. | 2015 | 25668647 |
| herpes simplex virus 2 (hsv-2) infected cell proteins are among the most dominant antigens of a live-attenuated hsv-2 vaccine. | virion glycoproteins such as glycoprotein d (gd) are believed to be the dominant antigens of herpes simplex virus 2 (hsv-2). we have observed that mice immunized with a live hsv-2 icp0- mutant virus, hsv-2 0δnls, are 10 to 100 times better protected against genital herpes than mice immunized with a hsv-2 gd subunit vaccine (plos one 6:e17748). in light of these results, we sought to determine which viral proteins were the dominant antibody-generators (antigens) of the live hsv-2 0δnls vaccine. w ... | 2015 | 25658852 |
| serological profile of hsv-2 in std patients: evaluation of diagnostic utility of hsv-2 igm and igg detection. | the present study was undertaken to determine herpes simplex virus-2 seroprevalence in sexually active adults aged 20-49 and to investigate the correlation with sociodemographic characteristics and to find its association with other sexually transmitted diseases especially hiv and also to assess the proportion of primary and reactivated hsv-2 cases. | 2014 | 25653947 |
| epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus. | human parechovirus (hpev) and human herpes virus-6 (hhv-6) are acquired commonly in infancy and associated with central nervous system infection. the prevalence of hpev and hhv-6 in the cerebrospinal fluid (csf) of infants tested for enterovirus (ev) and herpes-simplex virus (hsv) is unknown. all stored csf samples from ev or hsv testing in infants less than 6 months of age at children's hospital colorado between january 1, 2010 and december 31, 2011 were tested for hpev, hhv-6, ev, and hsv by p ... | 2015 | 25650069 |
| nkt cell activation by local α-galactosylceramide administration decreases susceptibility to hsv-2 infection. | nkt cells are a subgroup of t cells, which express a restricted tcr repertoire and are critical for the innate immune responses to viral infections. activation of nkt cells depends on the major histocompatibility complex-related molecule cd1d, which presents bioactive lipids to nkt cells. the marine sponge derived lipid αgalcer has recently been demonstrated as a specific agonist for activation of human and murine nkt cells. in the present study we investigated the applicability of αgalcer pre-t ... | 2015 | 25648689 |
| does offering human immunodeficiency virus testing at the time of blood donation reduce transfusion transmission risk and increase disclosure counseling? results of a randomized controlled trial, são paulo, brazil. | in a randomized controlled trial (rct) in a blood bank in são paulo, we tested the hypotheses that offering client-centered human immunodeficiency virus (hiv) counseling and testing to blood donors would: 1) reduce the risk of hiv contamination in the blood supply by diverting higher-risk, test-seeking donors away from donation and 2) increase return for results and referrals to care. | 2015 | 25646883 |
| houttuynia cordata targets the beginning stage of herpes simplex virus infection. | herpes simplex virus (hsv), a common latent virus in humans, causes certain severe diseases. extensive use of acyclovir (acv) results in the development of drug-resistant hsv strains, hence, there is an urgent need to develop new drugs to treat hsv infection. houttuynia cordata (h. cordata), a natural herbal medicine, has been reported to exhibit anti-hsv effects which is partly nf-κb-dependent. however, the molecular mechanisms by which h. cordata inhibits hsv infection are not elucidated thoro ... | 2015 | 25643242 |
| sensorineural hearing loss in hemorrhagic dengue? | dengue is an acute febrile infectious disease, with high fever followed by symptoms flu-like. dengue hemorrhagic fever (dhf) is a vascular leak syndrome and could present spontaneous bleeding and worsening of symptoms after some days. dengue could have some ent manifestations, however hearing loss is not one of them. sudden hearing loss is considered as sensorineural or perceptual hearing loss with a sudden onset in a person without other prior otological history. the relation between infectious ... | 2014 | 25625489 |
| herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization. | glycoprotein g (gg) from herpes simplex virus 1 and 2 (hsv-1 and hsv-2, important human neurotropic pathogens) is the first viral chemokine-binding protein found to potentiate chemokine function. here we show that gg attaches to cell surface glycosaminoglycans and induces lipid raft clustering, increasing the incorporation of cxcr4 receptors into these microdomains. gg induces conformational rearrangements in cxcr4 homodimers and changes their intracellular partners, leading to sustained, functi ... | 2015 | 25625471 |
| hormonal contraception and the risk of hiv acquisition: an individual participant data meta-analysis. | observational studies of a putative association between hormonal contraception (hc) and hiv acquisition have produced conflicting results. we conducted an individual participant data (ipd) meta-analysis of studies from sub-saharan africa to compare the incidence of hiv infection in women using combined oral contraceptives (cocs) or the injectable progestins depot-medroxyprogesterone acetate (dmpa) or norethisterone enanthate (net-en) with women not using hc. | 2015 | 25612136 |
| secreted herpes simplex virus-2 glycoprotein g modifies ngf-trka signaling to attract free nerve endings to the site of infection. | herpes simplex virus type 1 (hsv-1) and hsv-2 are highly prevalent viruses that cause a variety of diseases, from cold sores to encephalitis. both viruses establish latency in peripheral neurons but the molecular mechanisms facilitating the infection of neurons are not fully understood. using surface plasmon resonance and crosslinking assays, we show that glycoprotein g (gg) from hsv-2, known to modulate immune mediators (chemokines), also interacts with neurotrophic factors, with high affinity. ... | 2015 | 25611061 |
| global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012. | herpes simplex virus type 2 (hsv-2) infection causes significant disease globally. adolescent and adult infection may present as painful genital ulcers. neonatal infection has high morbidity and mortality. additionally, hsv-2 likely contributes substantially to the spread of hiv infection. the global burden of hsv-2 infection was last estimated for 2003. here we present new global estimates for 2012 of the burden of prevalent (existing) and incident (new) hsv-2 infection among females and males ... | 2015 | 25608026 |
| population and dyadic-based seroincidence of herpes simplex virus-2 and syphilis in southern india. | herpes simplex virus-2 (hsv-2) and syphilis are associated with increased risk of hiv, highlighting the importance of understanding their transmission dynamics. in india, most studies of hsv-2 and syphilis incidence are in high-risk populations and may not accurately reflect infectious activity. in this study, we aim to define hsv-2/syphilis incidence and risk factors in a population sample. | 2015 | 25605970 |
| sexually transmitted infections, benign prostatic hyperplasia and lower urinary tract symptom-related outcomes: results from the prostate, lung, colorectal and ovarian cancer screening trial. | to examine whether a history of sexually transmitted infections (stis) or positive sti serology is associated with prevalent and incident benign prostatic hyperplasia (bph)/lower urinary tract symptoms (luts)-related outcomes in the prostate, lung, colorectal and ovarian cancer screening trial. | 2015 | 25601300 |
| severe acute pharyngotonsillitis due to herpes simplex virus type 2 in a young woman. | whereas herpes simplex virus type 1 (hsv-1) is a recognized cause of acute oropharyngeal infection in young adults, hsv-2 infections are mostly associated with genital symptoms. we report a case of acute and prolonged febrile ulcerative pharyngotonsillitis with inflammatory syndrome which persisted despite antibiotic therapy for 8 days and required hospitalization in an 18-year old immune competent and sexually active female patient. hsv-2 was evidenced in tonsillar samples and blood by real tim ... | 2015 | 25600608 |
| risk of bacterial vaginosis among women with herpes simplex virus type 2 infection: a systematic review and meta-analysis. | bacterial vaginosis (bv) is a perturbation of vaginal flora characterized by reduced levels of lactobacilli and concomitant overgrowth of anaerobic bacterial species. bv is highly prevalent and associated with multiple adverse outcomes, including enhanced human immunodeficiency virus transmission. because recent reports reveal that herpes simplex virus type 2 (hsv-2) infection may increase bv risk, we initiated a systematic review and meta-analysis of the link between hsv-2 infection and bv. | 2015 | 25589333 |
| high expression level of antioxidants and pharmaceutical bioactivities of endophytic fungus chaetomium globosum jn711454. | in order to maximize antioxidant activity of pharmaceutical bioactive endophytic fungus chaetomium globosum jn711454 during fermentation process, designed fermentation experiments of culture media for three levels of eight culture factors were performed using a taguchi orthogonal array (oa) design with layout l18 (2(1) × 3(7)). the agitation and the potato extract were the most significant affecting factors, and their interaction contributed significantly to fungus activity. the production of an ... | 2016 | 25569373 |
| [study on the prevalence and associated risk factors related to hiv, syphilis, herpes simplex virus-2 among female sex workers in jiaozhou, shandong province]. | to analyze the prevalence rates and associated risk factors on hiv, syphilis, herpes simplex virus-2 (hsv-2) among female sex workers (fsws) in jiaozhou, shandong province. | 2014 | 25567012 |
| [the lysate and recombinant antigens in elisa-test-systems for diagnostic of herpes simplex]. | the lysate and recombinant antigens of various production included informula of elisa-test-systems were analyzed. the elisa-test-systems are used for detection of igg to herpes simplex virus type i and ii. for testing the panel of serums pth 201 (bbi inc.) were used. the samples of this panel contain antibodies to herpes simplex virus type i and ii in mixed titers. the 69 serums of donors were used too (17 samples had igg to herpes simplex virus type i, 23 samples to herpes simplex virus type ii ... | 2014 | 25552056 |
| heat exposure and bicycling trigger recurrent aseptic meningitis: a case report. | aseptic meningitis associated with herpes simplex virus type 2 often has a relapsing-remitting clinical phenotype. factors that lead to disease activation and reactivation are currently incompletely understood. | 2014 | 25551438 |
| first identification of the herpes simplex virus by skin-dedicated ex vivo fluorescence confocal microscopy during herpetic skin infections. | skin-dedicated ex vivo fluorescence confocal microscopy (fcm) has so far been used to identify cutaneous tumours on freshly excised samples using acridine orange as fluorochrome. | 2015 | 25545312 |
| functional comparison of herpes simplex virus 1 (hsv-1) and hsv-2 icp27 homologs reveals a role for icp27 in virion release. | numerous studies have focused on the regulatory functions of icp27, an immediate-early (ie) protein of herpes simplex virus 1 (hsv-1). however, its homolog in hsv-2, termed icp27t2, has been little studied. here, we used two different approaches to functionally compare icp27t2 and icp27. in transfection-based assays, icp27t2 closely resembled icp27 in its capacity to enhance hsv-1 late gene expression, suppress the splicing of a viral intron, and complement the growth of an hsv-1 icp27 null muta ... | 2015 | 25540385 |