Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| special feature: corynebacterium diphtheriae. | 1984 | 20475892 | |
| a tellurite medium for the identification and isolation of corynebacterium diphtheriae. | 1949 | 20475780 | |
| a simple tellurite-chocolate-agar medium for the typing and isolation of corynebacterium diphtheriae. | 1937 | 20475403 | |
| a modified tellurite medium for the detection and isolation of corynebacterium diphtheriae in routine diagnostic work. | 1937 | 20475379 | |
| a further analysis of the types of corynebacterium diphtheriae common to the glasgow area. | 1936 | 20475321 | |
| the incidence and clinical correlation of types of corynebacterium diphtheriae at romford, essex: a survey of 400 cases. | 1936 | 20475320 | |
| an analysis of 510 strains of corynebacterium diphtheriae. | 1933 | 20475209 | |
| the different types of corynebacterium diphtheriae. | 1933 | 20475198 | |
| a study of c. diphtheriae and other members of the genus corynebacterium with special reference to fermentative activity. | 1924 | 20474839 | |
| oligomeric state in the crystal structure of modular fad synthetase provides insights into its sequential catalysis in prokaryotes. | the crystal structure of the modular flavin adenine dinucleotide (fad) synthetase from corynebacterium ammoniagenes has been solved at 1.95 a resolution. the structure of c. ammoniagenes fad synthetase presents two catalytic modules-a c-terminus with atp-riboflavin kinase activity and an n-terminus with atp-flavin mononucleotide (fmn) adenylyltransferase activity-that are responsible for the synthesis of fad from riboflavin in two sequential steps. in the monomeric structure, the active sites fr ... | 2010 | 20471397 |
| [surface structures of gram-positive bacteria in intercellular interaction and film formation]. | 2010 | 20465012 | |
| a comparison of bacterial composition in diabetic ulcers and contralateral intact skin. | an extensive portion of the healthcare budget is allocated to chronic human infection. chronic wounds in particular are a major contributor to this financial burden. little is known about the types of bacteria which may contribute to the chronicity, biofilm and overall bioburden of the wound itself. in this study we compare the bacteriology of wounds and associated intact skin. wound and paired intact skin swabs (from a contralateral location) were collected. the bacterial diversity was determin ... | 2010 | 20461221 |
| concurrent outbreak of tuberculosis and caseous lymphadenitis in a goat herd. | 2010 | 20453237 | |
| odhi dephosphorylation kinetics during different glutamate production processes involving corynebacterium glutamicum. | in corynebacterium glutamicum, the activity of the 2-oxoglutarate dehydrogenase complex was shown to be controlled by the phosphorylation of a 15-kda protein odhi by different serine/threonine protein kinases. in this paper, the phosphorylation status and kinetics of odhi dephosphorylation were assessed during glutamate producing processes triggered by either a biotin limitation or a temperature upshock from 33 degrees c to 39 degrees c. a dephosphorylation of odhi in c. glutamicum 2262 was obse ... | 2010 | 20449744 |
| [actinomycosis of the temporal bone]. | 2011 | 20447789 | |
| codon usage patterns in corynebacterium glutamicum: mutational bias, natural selection and amino acid conservation. | the alternative synonymous codons in corynebacterium glutamicum, a well-known bacterium used in industry for the production of amino acid, have been investigated by multivariate analysis. as c. glutamicum is a gc-rich organism, g and c are expected to predominate at the third position of codons. indeed, overall codon usage analyses have indicated that c and/or g ending codons are predominant in this organism. through multivariate statistical analysis, apart from mutational selection, we identifi ... | 2010 | 20445740 |
| utilization of phenol and naphthalene affects synthesis of various amino acids in corynebacterium glutamicum. | this article reports multiple metabolic pathways of amino acid production via phenol and naphthalene use by corynebacterium glutamicum. biodegradation of phenol and naphthalene by c. glutamicum occurred in a mineral salt medium containing 1% yeast extract without any additional carbon sources. among the amino acids synthesized via the tca-cycle, glutamate synthesis increased in c. glutamicum supplemented with 8.5 mm phenol or with 4.2 mm naphthalene. aspartate synthesis significantly increased w ... | 2010 | 20443004 |
| macrolide, lincosamide, and streptogramin b-constitutive-type resistance in corynebacterium pseudodiphtheriticum isolated from upper respiratory tract specimens. | corynebacterium pseudodiphtheriticum is commonly found in normal upper respiratory tract flora in humans. in certain conditions it can cause the opportunistic infections, especially in immunocompromised patients. in certain strains of corynebacterium sp., the macrolide, lincosamide, and streptogramin b (mlsb) resistance mechanism related to the presence of the erm(x) gene was discovered; hence, the need appeared for further investigation to confirm the existence of this gene among c. pseudodipht ... | 2010 | 20438346 |
| subcellular localization and characterization of the parab system from corynebacterium glutamicum. | faithful segregation of chromosomes and plasmids is a vital prerequisite to produce viable and genetically identical progeny. bacteria use a specialized segregation system composed of the partitioning proteins para and parb to segregate certain plasmids. strikingly, homologues of para and parb are found to be encoded in many chromosomes. although mutations in the chromosomal par system have effects on segregation efficiency, the exact mechanism by which the chromosomes are segregated into the da ... | 2010 | 20435732 |
| coryneform bacteria associated with canine otitis externa. | this study aims to investigate the occurrence of coryneform bacteria in canine otitis externa. a combined case series and case-control study was carried out to improve the current knowledge on frequency and clinical significance of coryneform bacteria in samples from canine otitis externa. a total of 16 cases of otitis externa with involvement of coryneform bacteria were recorded at two referral veterinary hospitals in denmark and the us, respectively. coryneform bacteria were identified by part ... | 2010 | 20434850 |
| investigations and control measures following a non-travel-associated case of toxigenic cornyebacterium diphtheriae, london, united kingdom, december 2009-january 2010. | this article reports the investigation and control measures undertaken following the identification of a toxigenic strain of cornyebacterium diphtheriae var gravis, designated ribotype minsk , in a partially vaccinated teenager born in the united kingdom with no recent history of travel or known contact with a case of diphtheria or a carrier. this case highlights the need for ongoing work to improve vaccine uptake rates to ensure children receive all scheduled vaccinations. | 2010 | 20430002 |
| [etiology, resistance and diagnostic techniques in skin and skin structure infections]. | skin and soft tissue infections (ssti) are common and, generally, uncomplicated at the time of initial presentation. however, these infections can worsen quickly when there are delays in diagnosis and treatment. the clinical presentation of most ssti is the culmination of a microbial three-step process as follow: i) bacterial adherence to host cells; ii) invasion of tissue with evasion of host defences, and iii) elaboration of toxins. even if the microbiology of wounds has been actively investig ... | 2009 | 20428018 |
| distribution characteristics of airborne bacteria and fungi in the general hospitals of korea. | the objective of this study is to provide fundamental data related to size-based characteristics of bioaerosol distributed in the general hospital. measurement sites are main lobby, icu, surgical ward and biomedical laboratory and total five times were sampled with six-stage cascade impactor. mean concentrations of airborne bacteria and fungi were the highest in main lobby as followed by an order of surgical ward, icu and biomedical laboratory. the predominant genera of airborne bacteria identif ... | 2010 | 20424357 |
| udp-(5f)-glcnac acts as a slow-binding inhibitor of msha, a retaining glycosyltransferase. | glycosyltransferase enzymes play important roles in numerous cellular pathways. despite their participation in many therapeutically relevant pathways, there is a paucity of information on how to effectively inhibit this class of enzymes. here we report that udp-(5f)-glcnac acts as a slow-binding, competitive inhibitor of the retaining glycosyltransferase msha from corynebacterium glutamicum (k(i) approximately 1.6 mum). the kinetic data are consistent with a single-step inhibition mechanism whos ... | 2010 | 20411981 |
| systems-wide metabolic pathway engineering in corynebacterium glutamicum for bio-based production of diaminopentane. | in the present work the gram-positive bacterium corynebacterium glutamicum was engineered into an efficient, tailor-made production strain for diaminopentane (cadaverine), a highly attractive building block for bio-based polyamides. the engineering comprised expression of lysine decarboxylase (ldcc) from escherichia coli, catalyzing the conversion of lysine into diaminopentane, and systems-wide metabolic engineering of central supporting pathways. substantially re-designing the metabolism yielde ... | 2010 | 20381632 |
| cg2091 encodes a polyphosphate/atp-dependent glucokinase of corynebacterium glutamicum. | the corynebacterium glutamicum gene cg2091 is encoding a polyphosphate (polyp)/atp-dependent glucokinase (ppgk). previous work demonstrated the association of ppgk to polyp granules. the deduced amino acid sequence of ppgk shows 45% sequence identity to polyp/atp glucomannokinase of arthrobacter sp. strain km and 50% sequence identity to polyp glucokinase of mycobacterium tuberculosis h37rv. ppgk from c. glutamicum was purified from recombinant escherichia coli. polyp was highly preferred over a ... | 2010 | 20379711 |
| functional characterization of the glxr deletion mutant of corynebacterium glutamicum atcc 13032: involvement of glxr in acetate metabolism and carbon catabolite repression. | recently, a cyclic amp receptor protein homologue, glxr, was reported to bind to the upstream regions of several genes involved in the regulation of diverse physiological processes in corynebacterium glutamicum. however, the function of glxr has not yet been explored in c. glutamicum in vivo using a glxr deletion mutant. therefore, this study examines the role of glxr as a repressor in glyoxylate bypass and carbon catabolite repression (ccr) using a deletion mutant. the disruption of glxr result ... | 2010 | 20377641 |
| engineering corynebacterium glutamicum for isobutanol production. | the production of isobutanol in microorganisms has recently been achieved by harnessing the highly active 2-keto acid pathways. since these 2-keto acids are precursors of amino acids, we aimed to construct an isobutanol production platform in corynebacterium glutamicum, a well-known amino-acid-producing microorganism. analysis of this host's sensitivity to isobutanol toxicity revealed that c. glutamicum shows an increased tolerance to isobutanol relative to escherichia coli. overexpression of al ... | 2010 | 20376637 |
| central nervous system infections in filipino patients with systemic lupus erythematosus. | infections including those of the central nervous system (cns) are a major contributor to morbidity and mortality in systemic lupus erythematosus (sle). this case series describes the etiology, contributing factors and outcomes of cns infections in a group of filipino patients with sle. | 2009 | 20374352 |
| factors enhancing l-valine production by the growth-limited l-isoleucine auxotrophic strain corynebacterium glutamicum deltailva deltapanb ilvnm13 (peckailvbnc). | cell growth limitation is known to be an important condition that enhances l: -valine synthesis in corynebacterium glutamicum recombinant strains with l: -isoleucine auxotrophy. to identify whether it is the limited availability of l: -isoleucine itself or the l: -isoleucine limitation-induced rel-dependent ppgpp-mediated stringent response that is essential for the enhancement of l: -valine synthesis in growth-limited c. glutamicum cells, we deleted the rel gene, thereby constructing a relaxed ... | 2010 | 20364396 |
| a deficiency in arabinogalactan biosynthesis affects corynebacterium glutamicum mycolate outer membrane stability. | corynebacterineae is a specific suborder of gram-positive bacteria that includes mycobacterium tuberculosis and corynebacterium glutamicum. the ultrastructure of the cell envelope is very atypical. it is composed of a heteropolymer of peptidoglycan and arabinogalactan (ag) covalently associated to an outer membrane. five arabinosyltransferases are involved in the biosynthesis of ag in c. glutamicum. aftb catalyzes the transfer of araf (arabinofuranosyl) onto the arabinan domain of the arabinogal ... | 2010 | 20363942 |
| novel corynebacterium diphtheriae in domestic cats. | novel nontoxigenic corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. contact investigation and carrier study of human and animal contacts yielded 3 additional, identical isolates from cats, although no evidence of zoonotic transmission was identified. molecular methods distinguished the feline isolates from known c. diphtheriae. | 2010 | 20350389 |
| antibody response to alkali-soluble protein extracts of corynebacterium diphtheriae and derived variants. | 1947 | 20344315 | |
| observations on the variant types of corynebacterium diphtheriae; antigenic analysis. | 1947 | 20342004 | |
| corynebacterium ulcerans bronchopneumonia in a dog. | 2010 | 20337919 | |
| common patterns - unique features: nitrogen metabolism and regulation in gram-positive bacteria. | gram-positive bacteria have developed elaborate mechanisms to control ammonium assimilation, at the levels of both transcription and enzyme activity. in this review, the common and specific mechanisms of nitrogen assimilation and regulation in gram-positive bacteria are summarized and compared for the genera bacillus, clostridium, streptomyces, mycobacterium and corynebacterium, with emphasis on the high g+c genera. furthermore, the importance of nitrogen metabolism and control for the pathogeni ... | 2010 | 20337720 |
| carbohydrate metabolism in corynebacterium glutamicum and applications for the metabolic engineering of l-lysine production strains. | carbohydrates exclusively serve as feedstock for industrial amino acid production with corynebacterium glutamicum. due to the industrial interest, knowledge about the pathways for carbohydrate metabolization in c. glutamicum steadily increases, enabling the rational design of optimized strains and production processes. in this review, we provide an overview of the metabolic pathways for utilization of hexoses (glucose, fructose), disaccharides (sucrose, maltose), pentoses (d-ribose, l-arabinose, ... | 2010 | 20333512 |
| [clinical and microbiological profile of women with bacterial vaginosis]. | to study the clinical and microbiological profile of women with bacterial vaginosis participating in a randomized, double-blind clinical trial, which compared the vaginal use of preparations from red pepper tree and metronidazole for the treatment of genital discharge. | 2010 | 20305946 |
| control of caseous lymphadenitis in six sheep flocks using clinical examination and regular elisa testing. | in an effort to control the spread of caseous lymphadenitis (cla) infection, flocks of affected sheep on six holdings were tested serologically at regular intervals using an antibody elisa with a mean (sd) specificity of 99 (1) per cent and a sensitivity of 79 (5) per cent. western blot assays to detect antibodies to the phospholipase d (pld) exotoxin of corynebacterium pseudotuberculosis were used as a further test when elisa results were inconclusive. owners were advised to remove from the flo ... | 2010 | 20305291 |
| the control of corynebacterium pseudotuberculosis infection in sheep flocks: a mathematical model of the impact of vaccination, serological testing, clinical examination and lancing of abscesses. | a mathematical model of corynebacterium pseudotuberculosis infection in sheep flocks was used to evaluate strategies for control and elimination of caseous lymphadenitis (cla). control strategies tested were vaccination, serological testing and removal of seropositives, clinical examination and removal of sheep with abscesses, lancing abscesses, and appropriate combinations. three different infection rates with and without replacement of culled ewes were used to evaluate the control options. con ... | 2010 | 20304509 |
| the fha domain of odhi interacts with the carboxyterminal 2-oxoglutarate dehydrogenase domain of odha in corynebacterium glutamicum. | in corynebacterium glutamicum, the unphosphorylated 15-kda odhi protein inhibits the activity of the 2-oxoglutarate dehydrogenase complex (odhc) by binding to odha, which in corynebacteria and mycobacteria is a large fusion protein with two major domains exhibiting structural features of e1o and e2 proteins. using copurification and surface plasmon resonance experiments with different odhi and odha length variants it was shown that the entire forkhead-associated (fha) domain of odhi and the c-te ... | 2010 | 20303957 |
| some practical aspects of corynebacterium pyogenes infections in cattle. | 1947 | 20295959 | |
| sequel to inoculation against corynebacterium pyogenes (summer) mastitis; full text of mr. justice hallett's judgment in the chester case. | 1947 | 20295956 | |
| antigenic relationship between the genus mycobacterium and the genus corynebacterium in goats and cattle. | 1947 | 20295886 | |
| studies on corynebacterium renale; penicillin treatment of experimentally infected mice. | 1947 | 20293735 | |
| penicillin and sulfadiazine sensitivity of 385 strains of corynebacterium diphtheriae. | 1947 | 20292352 | |
| infection with corynebacterium pyogenes in man. | 1947 | 20288649 | |
| production of substance b by corynebacterium diphtheriae, in relation to type of strain and severity of toxaemia. | 1947 | 20284033 | |
| use of coagulated plain serum for maintenance of corynebacterium diphtheriae. | 1946 | 20280186 | |
| typing of corynebacterium diphtheriae in queensland. | 1946 | 20277619 | |
| studies on c. pyogenes antitoxin in relation to immunity; the effect of alum-precipitated toxoid and vaccine on the artificial infection of the udder of the ewe with c. pyogenes. | 1947 | 20273228 | |
| studies on c. pyogenes antitoxin in relation to immunity; the production of c. pyogenes antitoxin in the serum of normal dairy cows following the inoculation of alum-precipitated toxoid and of a commercial toxoid. | 1947 | 20273227 | |
| diphtheria toxin; the iron enzymes of corynebacterium diphtheriae and their possible relation to diphtheria toxin. | 1947 | 20272110 | |
| further studies on the immunization of rabbits to toxigenic corynebacterium diphtheriae by injections of nontoxigenic diphtheria bacilli. | 1947 | 20268122 | |
| haemolytic activity of c. diphtheriae. | 1947 | 20266357 | |
| soil bacteria similar in morphology to mycobacterium and corynebacterium. | 1947 | 20266332 | |
| the bacterial flora found in the vagina of dairy cows with special reference to corynebacteria. | 1947 | 20265762 | |
| a medium for maintenance of the toxigenicity of corynebacterium diphtheriae. | 1947 | 20264822 | |
| a protest against the misuse of the generic name corynebacterium. | 1947 | 20255106 | |
| the types of corynebacterium diphtheriae found in glasgow during the last 15 years, with some account of their epidemiological relationships. | 1947 | 20251878 | |
| corynebacterium ovis associated with arthritis in lambs. | 1947 | 20251188 | |
| transcriptional regulation of histidine biosynthesis genes in corynebacterium glutamicum. | corynebacterium glutamicum, a gram-positive bacterium, has been widely used for industrial amino acid production. corynebacterium glutamicum his genes are located and transcribed in two unlinked loci, hiseg and hisdcb-orf1-orf2-hisha-impa-hisfi. the latter his operon starts the transcription at the c residue localized 196 bp upstream of the hisd atg start codon. our computer-based sequence analysis showed that the region corresponding to the untranslated 5' end of the transcript, named the hisd ... | 2010 | 20237580 |
| genetic and functional analysis of the soluble oxaloacetate decarboxylase from corynebacterium glutamicum. | soluble, divalent cation-dependent oxaloacetate decarboxylases (odx) catalyze the irreversible decarboxylation of oxaloacetate to pyruvate and co(2). although these enzymes have been characterized in different microorganisms, the genes that encode them have not been identified, and their functions have been only poorly analyzed so far. in this study, we purified a soluble odx from wild-type c. glutamicum about 65-fold and used matrix-assisted laser desorption ionization-time of flight (maldi-tof ... | 2010 | 20233922 |
| replication methods and tools in high-throughput cultivation processes - recognizing potential variations of growth and product formation by on-line monitoring. | high-throughput cultivations in microtiter plates are the method of choice to express proteins from recombinant clone libraries. such processes typically include several steps, whereby some of them are linked by replication steps: transformation, plating, colony picking, preculture, main culture and induction. in this study, the effects of conventional replication methods and replication tools (8-channel pipette, 96-pin replicators: steel replicator with fixed or spring-loaded pins, plastic repl ... | 2010 | 20233443 |
| evaluation of otoscope cone disinfection techniques and contamination level in small animal private practice. | the objective of this study was to evaluate the level of bacterial contamination of otoscope cones in veterinary private practice, and to determine the most effective method of disinfection. fifty small animal practices participated in this study, which included a detailed survey regarding otoscope cleaning, storage and usage and quantitative culture of the cleaned and stored otoscope cones. using sterile technique, two cones from each of the 50 hospitals were swabbed and submitted for quantitat ... | 2010 | 20230588 |
| microbial keratitis after lasik. | to report cases of microbial keratitis after lasik from a tropical climatic zone. | 2010 | 20229954 |
| population dynamics of two antilisterial cheese surface consortia revealed by temporal temperature gradient gel electrophoresis. | surface contamination of smear cheese by listeria spp. is of major concern for the industry. complex smear ecosystems have been shown to harbor antilisterial potential but the microorganisms and mechanisms involved in the inhibition mostly remain unclear, and are likely related to complex interactions than to production of single antimicrobial compounds. bacterial biodiversity and population dynamics of complex smear ecosystems exhibiting antilisterial properties in situ were investigated by tem ... | 2010 | 20222967 |
| [microecological and electron microscopic study of skin microbiota in patients with atopic dermatitis]. | bacteriological and electron microscopic study of skin of healthy persons and patients with atopic dermatitis (ad). | 2010 | 20222186 |
| [assessment of different regimens of diphtheria serotherapy]. | efficacy of different treatment regimens with equine diphtheria antitoxin (eda) was assessed on clinical samples as well as in experiments on animals. | 2010 | 20218350 |
| [monitoring of antibodies against diphtheria, tetanus and pertussis in pregnant women]. | to assess antibody levels against diphtheria, pertussis, and tetanus in pregnant women. | 2010 | 20218342 |
| engineering of sugar metabolism of corynebacterium glutamicum for production of amino acid l-alanine under oxygen deprivation. | corynebacterium glutamicum was genetically engineered to produce l-alanine from sugar under oxygen deprivation. the genes associated with production of organic acids in c. glutamicum were inactivated and the alanine dehydrogenase gene (alad) from lysinibacillus sphaericus was overexpressed to direct carbon flux from organic acids to alanine. although the alad-expressing strain produced alanine from glucose under oxygen deprivation, its productivity was relatively low due to retarded glucose cons ... | 2010 | 20217078 |
| studies on substrate utilisation in l-valine-producing corynebacterium glutamicum strains deficient in pyruvate dehydrogenase complex. | the pyruvate dehydrogenase complex was deleted to increase precursor availability in corynebacterium glutamicum strains overproducing l: -valine. the resulting auxotrophy is treated by adding acetate in addition glucose for growth, resulting in the puzzling fact of gluconeogenic growth with strongly reduced glucose uptake in the presence of acetate in the medium. this result was proven by intracellular metabolite analysis and labelling experiments. to increase productivity, the sugr protein invo ... | 2010 | 20204663 |
| [influence of contact with hospital environment on sensitivity to antibiotics of lipophilic strains of corynebacterium residing on human skin]. | sensitivity of two groups of lipophilic corynebacteria strains of different species, which form stable residential flora on human skin, to therapeutically significant groups of antibiotic was compared. strains were isolated from people who did not have any contact with hospital environment, and from doctors closely connected with hospital. it was shown that strains isolated from doctors, which were in fact not under antibiotic pressure, were five times more multiresistant whilst at the same time ... | 2009 | 20201326 |
| [production of auxins by the endophytic bacteria of winter rye]. | the ability of the actinomycetes and coryneform bacteria isolated from the root tissues of winter rye to produce auxin in a liquid culture was studied. the isolates of coryneform bacteria produced indolyl-3-acetic acid (iaa) into the medium in the amount of 9.0-95.0 microg/ml and the isolates of actinomycetes in the amount of 39.5-83.0 microg/ml. the maximal iaa accumulation in culture liquid of actinomycetes coincided, in general, with the beginning of the stationary growth phase. the dependenc ... | 2010 | 20198917 |
| polyprenylated benzoylphloroglucinol-type derivatives including novel cage compounds from hypericum erectum. | hyperici erecti herba (hypericum erectum thunb.) showed a suppressive effect on generation of isovaleric acid by corynebacterium xerosis. an ethyl acetate (acoet) soluble fraction of methanol extract of h. erectum showed the activity. the acoet fraction was separated by various successive choromatographical methods to give seven new compounds 1-7 along with some known compounds. the structures of the new compounds were elucidated to be polyprenylated benzoylphloroglucinol derivatives by means of ... | 2010 | 20190438 |
| identification of airborne bacterial and fungal species in the clinical microbiology laboratory of a university teaching hospital employing ribosomal dna (rdna) pcr and gene sequencing techniques. | universal or "broad-range" pcr-based ribosomal dna (rdna) was performed on a collection of 58 isolates (n = 30 bacteria + 28 fungi), originating from environmental air from several locations within a busy clinical microbiology laboratory, supporting a university teaching hospital. a total of 10 bacterial genera were identified including both gram-positive and gram-negative genera. gram-positive organisms accounted for 27/30 (90%) of total bacterial species, consisting of seven genera and include ... | 2009 | 20183192 |
| polyphosphate/atp-dependent nad kinase of corynebacterium glutamicum: biochemical properties and impact of ppnk overexpression on lysine production. | nicotinamide adenine dinucleotide phosphate (nadp) is synthesized by phosphorylation of either oxidized or reduced nicotinamide adenine dinucleotide (nad/nadh). here, the cg1601/ppnk gene product from corynebacterium glutamicum genome was purified from recombinant escherichia coli and enzymatic characterization revealed its activity as a polyphosphate (polyp)/atp-dependent nad kinase (ppnk). ppnk from c. glutamicum was shown to be active as homotetramer accepting polyp, atp, and even adp for pho ... | 2010 | 20180116 |
| corynebacterium jeikeium bacteremia in a hemodialyzed patient. | corynebacterium jeikeium, frequently encountered in clinical specimens, is part of the normal skin flora. nevertheless, a few cases of c. jeikeium bacteremia followed by severe clinical manifestations have been reported. c. jeikeium has been reported to cause endocarditis, septicemia, meningitis, pneumonia and osteomyelitis, along with soft tissue and trauma infections. herein we describe a case of c. jeikeium bacteremia in greece. the isolation of a coryneform bacterium from a clinical specimen ... | 2010 | 20171132 |
| [two cases of corynebacterium pseudodiphtheriticum respiratory tract infection]. | corynebacterium pseudodiphtheriticum, one cause of respiratory tract infection, is rarely considered as a pathogen because it is among normal bacterial flora colonizing the oral cavity. we report two cases of c. pseudodiphtheriticum causing respiratory tract infection--an exacerbation of chronic obstructive pulmonary disease and pneumonia--, both in the presence of underlying respiratory disease. both required antibiotics after first-line chemotherapy failed. isolates were susceptible to beta-la ... | 2010 | 20170017 |
| surface microbiota analysis of taleggio, gorgonzola, casera, scimudin and formaggio di fossa italian cheeses. | the composition of the bacterial consortia of the smear italian cheeses and their role on quality and safety is still poorly understood. the objective of this study was to identify and characterize the bacterial communities present on the surface of five traditional italian cheeses, casera valtellina, scimudin, formaggio di fossa, gorgonzola and taleggio. dgge analysis performed using total dna obtained from cheese surfaces enabled us to identify the dominant bacterial populations. bands showing ... | 2010 | 20167385 |
| two cases of aneurysm of the anterior mitral valve leaflet associated with transcatheter aortic valve endocarditis: a mere coincidence? | 2010 | 20167335 | |
| improved diagnosis of periprosthetic joint infection by multiplex pcr of sonication fluid from removed implants. | the microbiological diagnosis of periprosthetic joint infection (pji) is crucial for successful antimicrobial treatment. cultures have limited sensitivity, especially in patients receiving antibiotics. we evaluated the value of multiplex pcr for detection of microbial dna in sonication fluid from removed orthopedic prostheses. cases of pji in which the prosthesis (or part of it) was removed were prospectively included. the removed implant was sonicated, and the resulting sonication fluid was cul ... | 2010 | 20164283 |
| spectrum of activity, mutation rates, synergistic interactions, and the effects of ph and serum proteins for fusidic acid (cem-102). | fusidic acid (cem-102) is a steroidal antimicrobial agent with focused gram-positive activity that acts by preventing bacterial protein synthesis via interacting with elongation factor g. a collection of 114 wild-type isolates (> 80 species) was used to define the contemporary limits of fusidic acid spectrum against gram-positive and gram-negative species. reference broth microdilution and anaerobic agar dilution methods were performed. modifications of standardized test methods included adding ... | 2010 | 20159376 |
| molecular and phylogenetic analysis of pyridoxal phosphate-dependent acyltransferase of exiguobacterium acetylicum. | the pyridoxal-5'-phosphate (plp)-dependent family of enzymes is a very diverse group of proteins that metabolize small molecules like amino acids and sugars, and synthesize cofactors for other metabolic pathways through transamination, decarboxylation, racemization, and substitution reactions. in this study we employed degenerated primer-based pcr amplification, using genomic dna isolated from the soil bacterium exiguobacterium acetylicum strain sn as template. we revealed the presence of a plp- ... | 2009 | 20158163 |
| 13c metabolic flux analysis for larger scale cultivation using gas chromatography-combustion-isotope ratio mass spectrometry. | (13)c-based metabolic flux analysis ((13)cmfa) is limited to smaller scale experiments due to very high costs of labeled substrates. we measured (13)c enrichment in proteinogenic amino acid hydrolyzates using gas chromatography-combustion-isotope ratio mass spectrometry (gc-c-irms) from a series of parallel batch cultivations of corynebacterium glutamicum utilizing mixtures of natural glucose and [1-(13)c] glucose, containing 0%, 0.5%, 1%, 2%, and 10% [1-(13)c] glucose. decreasing the [1-(13)c] ... | 2010 | 20149889 |
| metabolic changes in a pyruvate kinase gene deletion mutant of corynebacterium glutamicum atcc 13032. | to investigate primary effects of a pyruvate kinase (pyk) defect on glucose metabolism in corynebacterium glutamicum, a pyk-deleted mutant was derived from wild-type c. glutamicum atcc13032 using the double-crossover chromosome replacement technique. the mutant was then evaluated under glutamic acid-producing conditions induced by biotin limitation. the mutant showed an increased specific rate of glucose consumption, decreased growth, higher glutamic acid production, and aspartic acid formation ... | 2010 | 20144730 |
| analysis and engineering of metabolic pathway fluxes in corynebacterium glutamicum. | the gram-positive soil bacterium corynebacterium glutamicum was discovered as a natural overproducer of glutamate about 50 years ago. linked to the steadily increasing economical importance of this microorganism for production of glutamate and other amino acids, the quest for efficient production strains has been an intense area of research during the past few decades. efficient production strains were created by applying classical mutagenesis and selection and especially metabolic engineering s ... | 2010 | 20140657 |
| development of a loop-mediated isothermal amplification assay for the detection of mycobacterium bovis. | bovine tuberculosis caused by mycobacterium bovis is an important zoonosis. in this study, a simple, rapid method for detecting this organism was developed based on loop-mediated isothermal amplification of the mpt83 gene. the technique will be of value in the clinical and field-based diagnosis of m. bovis and can differentiate it from other bacteria such as corynebacterium diphtheriae, streptococcus pneumoniae, β-haemolytic streptococci, pseudomonas aeruginosa, yersinia pseudotuberculosis, stap ... | 2011 | 20138787 |
| molecular analysis of bacterial population structure and dynamics during cold storage of untreated and treated milk. | spoilage bacteria in milk are controlled by treatments such as thermization, microfiltration and addition of carbon dioxide. however, little information is known about the changes in microbial communities during subsequent cold storage of treated milk. culture-dependent methods and a direct molecular approach combining 16s rrna gene clone libraries and quantitative pcr (q-pcr) were applied to obtain a better overview of the structure and the dynamics of milk microbiota. raw milk samples were tre ... | 2010 | 20137820 |
| complete genome sequence and lifestyle of black-pigmented corynebacterium aurimucosum atcc 700975 (formerly c. nigricans cn-1) isolated from a vaginal swab of a woman with spontaneous abortion. | corynebacterium aurimucosum is a slightly yellowish, non-lipophilic, facultative anaerobic member of the genus corynebacterium and predominantly isolated from human clinical specimens. unusual black-pigmented variants of c. aurimucosum (originally named as c. nigricans) continue to be recovered from the female urogenital tract and they are associated with complications during pregnancy. c. aurimucosum atcc 700975 (c. nigricans cn-1) was originally isolated from a vaginal swab of a 34-year-old wo ... | 2010 | 20137072 |
| approaching the complexity of elastase-digested membrane proteomes using off-gel ief/nlc-maldi-ms/ms. | liquid chromatography, coupled with tandem mass spectrometry, is an established method for the identification of proteins from a complex sample. despite its wide application, the analysis of whole proteomes still represents a challenge to researchers, because of the complexity and dynamic range of protein concentrations in biological samples. the analysis of such samples can be improved by adding a prefractionation step or a combination of orthogonal separation techniques. off-gel isoelectric fo ... | 2010 | 20136094 |
| enhancement of ornithine production in proline-supplemented corynebacterium glutamicum by ornithine cyclodeaminase. | in this study, corynebacterium glutamicum and its derived mutants were used to demonstrate the relationship between proline, glutamate and ornithine. the maximum ornithine production was shown in the culture medium (3295.0 mg/l) when the cells were cultured with 20 mm proline and was 15.5 times higher than in the presence of 1 mm proline. however, glutamate, which known as an intermediate in the process of converting proline to ornithine, did not have any positive effect on ornithine production. ... | 2010 | 20134243 |
| antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation. | the synthesis of nine nostocarboline derivatives with substitutions of the 2-methyl group by alkyl, aryl and functionalized residues, 10 symmetrical bis cationic dimers linking 6-cl-norharmane through the 2-position and fifteen derivatives of the marine alkaloids eudistomin n and o is reported. these compounds were evaluated in vitro against four parasites (trypanosoma brucei rhodesiense stib 900, trypanosoma cruzi tulahuen c2c4, leishmania donovani mhom-et-67/l82 axenic amastigotes, and plasmod ... | 2010 | 20133138 |
| colored sweat caused by pseudochromhidrosis. | 2010 | 20124247 | |
| suppurative adenitis of preputial glands associated with corynebacterium mastitidis infection in mice. | suppuration of the preputial gland in mice occurs as a septic complication of fight wounds around the external genitalia. currently reported bacterial isolates from these lesions are limited to staphylococcus aureus, pasteurella pneumotropica, and klebsiella oxytoca. in the context of a pilot experiment aimed at defining the aging phenotype of estrogen receptor beta knockout (berko) mice, 2 male mice (1 of the berko line and the other from the age- and sex-matched wild-type control group) were d ... | 2010 | 20122320 |
| distribution of aerobic motile and non-motile bacteria within the capillary fringe of silica sand. | retention of bacterial cells as "particles" by silica sand during formation of a capillary fringe (cf) and the influence of motility was examined with motile pseudomonas putida and non-motile corynebacterium glutamicum suspensions in the absence of nutrients. the fractional retention of c. glutamicum cells at all regions of the cf was higher than for p. putida cells, most probably due to the motility of p. putida. only about 5% of p. putida cells and almost no c. glutamicum cells reached the upp ... | 2010 | 20116084 |
| sick as a dog. | 2010 | 20113976 | |
| orthophosphate binding at the dimer interface of corynebacterium callunae starch phosphorylase: mutational analysis of its role for activity and stability of the enzyme. | orthophosphate recognition at allosteric binding sites is a key feature for the regulation of enzyme activity in mammalian glycogen phosphorylases. protein residues co-ordinating orthophosphate in three binding sites distributed across the dimer interface of a non-regulated bacterial starch phosphorylase (from corynebacterium callunae) were individually replaced by ala to interrogate their unknown function for activity and stability of this enzyme. | 2010 | 20113461 |
| functional characterization of the glxr deletion mutant of corynebacterium glutamicum atcc 13032: involvement of glxr in acetate metabolism and carbon catabolite repression. | abstract recently, a cyclic amp receptor protein homologue, glxr, was reported to bind to the upstream regions of several genes involved in the regulation of diverse physiological processes in corynebacterium glutamicum. however, the function of glxr has not yet been explored in c. glutamicum in vivo using a glxr deletion mutant. therefore, this study examines the role of glxr as a repressor in glyoxylate bypass and carbon catabolite repression (ccr) using a deletion mutant. the disruption of gl ... | 2010 | 20113353 |
| a novel redox-sensing transcriptional regulator cyer controls expression of an old yellow enzyme family protein in corynebacterium glutamicum. | corynebacterium glutamicum cgr_2930 (cyer) encodes a transcriptional regulator of the arsr family. its gene product, cyer, was shown here to repress the expression of cyer and the cgr_2931 (cye1)-cgr_2932 operon, which is located upstream of cyer in the opposite orientation. the cye1 gene encodes an old yellow enzyme family protein, members of which have been implicated in the oxidative stress response. cyer binds to the intergenic region between cyer and cye1. expression of cyer and cye1 is ind ... | 2010 | 20110293 |