Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| no associations established between single nucleotide polymorphisms in human toll-like receptor 2 and toll-interacting protein and staphylococcus aureus bloodstream infections. | staphylococcus aureus bloodstream infections (sabsi) are associated with high morbidity and mortality. the toll-like receptor 2 (tlr2) and toll-interacting protein (tollip) are important in recognition and regulation of human innate immunity response to s. aureus. single nucleotide polymorphisms (snps) in the tlr2 and tollip encoding genes have been associated with disease, including bsi. the aim of this study was to examine potential associations between a selection of snps in the genes encodin ... | 2017 | 28736863 |
| secondary metabolites from the leaves of the medicinal plant goldenseal (hydrastis canadensis). | the study presented herein constitutes an extensive investigation of constituents in hydrastis canadensis l. (ranunculaceae) leaves. it describes the isolation and identification of two previously unknown compounds, 3,4-dimethoxy-2-(methoxycarbonyl)benzoic acid (1) and 3,5,3'-trihydroxy-7,4'-dimethoxy-6,8-c-dimethyl-flavone (2), along with the known compounds (±)-chilenine (3), (2r)-5,4'-dihydroxy-6-c-methyl-7-methoxy-flavanone (4), 5,4'-dihydroxy-6,8-di-c-methyl-7-methoxy-flavanone (5), noroxyh ... | 2017 | 28736584 |
| [emergence of methicillin-resistant staphylococcus aureus sccmec type iv/v epidemic clones in a large teaching hospital in china]. | to investigate the staphylococcal cassette chromosome mec (sccmec) genotype and molecular epidemiological characteristics of healthcare-associated methicillin-resistant staphylococcus aureus (ha-mrsa) in a large teaching hospital in china. | 2017 | 28736358 |
| iodine-lithium-alpha-dextrin (ilαd) against staphylococcus aureus skin infections: a comparative study of in vitro bactericidal activity and cytotoxicity between ilαd and povidone-iodine. | as antimicrobial resistance continuously increases, revisiting old antimicrobial agents, modified to enhance efficacy and safety, becomes important. iodine has been widely used for more than 150 years as a wound and skin disinfectant; it is an effective broad range bactericide, and to date, it lacks reports of resistance development. the most important iodine-based agent is povidone-iodine (pvp-i) which provides excellent antibacterial activity. however, its safety profile has been questioned. | 2017 | 28736269 |
| a novel ccr-2/tlr-2 triggered signaling in murine peritoneal macrophages intensifies bacterial (staphylococcus aureus) killing by reactive oxygen species through tnf-r1. | macrophages are remarkably versatile in their ability to recognize and respond to a wide range of stimuli by expressing a variety of surface and intracellular receptors and triggering multiple signal transduction pathways. the onset of microbial infection is primarily determined by the initial contacts made by the microbes with the host macrophages. although there prevail a relationship between the chemokine receptor and toll like receptors during disease, particularly tlr-2 and ccr-2 signaling ... | 2017 | 28736159 |
| construction of multilayer alginate hydrogel beads for oral delivery of probiotics cells. | multilayer alginate hydrogel beads (mahbs), which were prepared by emulsion method, had been fabricated via the ionic crosslinking between calcium ion (ca(2+)) and carboxylic group of alginate and utilized as encapsulating material for oral delivery of a model probiotic bacteria bifidobacterium breve. optical and fluorescence microscopy obviously showed the microorganism cells were encapsulated in the core beads. the viability of b. breve cells encapsulated in mahbs was significantly enhanced co ... | 2017 | 28736041 |
| antioxidant and antibacterial activities of pelargonium asperum and ormenis mixta essential oils and their synergistic antibacterial effect. | in this work, the chemical composition, the antioxidant, and the antibacterial activities of two moroccan essential oils less studied, extracted from pelargonium asperum and ormenis mixta, were investigated. according to the gas chromatography coupled to mass spectrometry analysis, citronellol (25.07%), citronellyl ester (10.52%), geraniol (10.46%), and buthyl anthranilate (5.93%) were found to be the major components of p. asperum, while o. mixta was mainly composed of d-germacrene (11.46%), 1, ... | 2017 | 28735475 |
| evaluation of anthelmintic antimicrobial and antioxidant activity of chenopodium album. | the objective of this study was to evaluate the anthelmintic, antimicrobial and antioxidant activities of chenopodium album against gastrointestinal nematodes of sheep and some pathogenic microbes. a worm motility inhibition assay was used for in vitro study, and a faecal egg count reduction assay was used for an in vivo study. various concentrations ranging from 100 to 500 μg/ml of the extract were subjected to antimicrobial screening by disc diffusion method against four selected bacterial (st ... | 2017 | 28735356 |
| antistaphylococcal activity of selected thiourea derivatives. | five of thiourea derivatives were prepared using as a starting compound 3-(trifluoromethyl)aniline, 4-chloro-3-nitroaniline, 1,3-thiazol-2-amine, 2h-1,2,3-triazol-4-amine and commercial isothiocyanates. all compounds were evaluated in vitro for antimicrobial activity. derivatives 2 and 3 showed the highest inhibition against gram-positive cocci (standard and hospital strains). the observed mic values were in the range of 0.5-8 μg/ml. the products effectively inhibited the formation of biofilms o ... | 2017 | 28735329 |
| trends of bloodstream infections in a university greek hospital during a three-year period: incidence of multidrug-resistant bacteria and seasonality in gram-negative predominance. | the aim of the study was to assess the epidemiology, the incidence of multidrug-resistant bacteria and bloodstream infections' (bsis) seasonality in a university hospital. this retrospective study was carried out in the university general hospital of patras, greece, during 2011-13 y. blood cultures from patients with clinical presentation suggestive of bloodstream infection were performed by the bact/alert system. isolates were identified by vitek 2 advanced expert system. antibiotic susceptibil ... | 2017 | 28735318 |
| endoscope assisted abscess drainage secondary to endoscope-assisted tlif - 1 year follow up. | endoscopic discectomy and fusions have been gaining popularity in the recent past and are noted to be safe for its application in elderly population. it involves ultra-small incision for discectomy followed by placement of percutaneous screws in awake patients. treatment of advanced spinal pathology using endoscope-assisted techniques are challenging. although not common with endoscopic approach, post-operative infection can be problematic as there are no established guidelines on its management ... | 2017 | 28735135 |
| withdrawn: incidence of methicillin resistant staphylococcus aureus (mrsa) in microbial community of cancer patients and evaluation of their resistant pattern. | this article has been withdrawn at the request of the author(s) and/or editor. the publisher apologizes for any inconvenience this may cause. the full elsevier policy on article withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. | 2017 | 28735083 |
| anti-inflammatory activity of cecropin-a2 from musca domestica. | this study aimed to investigate the anti-inflammatory activity of musca domestica cecropin-a2 (mdc-a2) toward staphylococcus aureus (s. aureus) to learn more about their immunological functions. raw264.7 cells were transfected with recombinant lentiviruses introduce plex-mdc-a2into the raw264.7 cell line (raw-mdc-a2). the raw264.7 cell line with empty plex (raw-plex) was produced in the same manner as a negative control. real-time quantitative reverse transcription pcr (rt-pcr) was performed to ... | 2017 | 28735081 |
| molecular analysis of virulence genes and the accessory gene regulator (agr) types among methicillin resistant staphylococcus aureus (mrsa) strains. | methicillin resistant s. aureus (mrsa) strains are a main cause of hospital-acquired infections and are considered as a serious public-health concern. mrsa isolates have plenty of virulence factors, which are the basis for its pathogenicity. the controlling and coordination of the expression of these genes perform by the accessory gene regulator (agr). the aim of this study was to determine the rate of some virulence genes encoding the enterotoxin, exfoliative toxin genes (eta), the adhesin gene ... | 2017 | 28735055 |
| linezolid activity against clinical gram-positive cocci with advanced antimicrobial drug resistance in iran. | the aim of the study was to investigate the linezolid activity against clinical gram-positive cocci with advanced antimicrobial drug resistance. | 2017 | 28735054 |
| activity of dalbavancin tested against gram-positive clinical isolates causing skin and skin structure infections in paediatric patients from us hospitals (2014 - 2015). | this study provides an in vitro analysis of dalbavancin activity against isolates causing skin and skin structure infections (sssis) in children. | 2017 | 28735053 |
| spa typing and identification of pvl genes of meticillin-resistant staphylococcus aureus isolated from a libyan hospital in tripoli. | the purpose of the study was to investigate the molecular characteristics of meticillin-resistant staphylococcus aureus (mrsa) isolated from clinical sources in tripoli, libya. | 2017 | 28735052 |
| telavancin activity in vitro tested against a worldwide collection of gram-positive clinical isolates (2014). | telavancin activity was measured against gram-positive pathogens collected worldwide during 2014 using the revised broth microdilution testing method. the results were compared with previous reports. | 2017 | 28735051 |
| in vitro activity of daptomycin combinations with rifampicin, gentamicin, fosfomycin and fusidic acid against mrsa strains. | although new antimicrobial agents designed to treat infections with limited therapeutic options have been introduced in the past few years, resistant gram positive cocci have continued to emerge and spread. daptomycin is a cyclic lipopeptide antibiotic that has rapid bactericidal activity against broad spectrum of gram positive bacteria, including methicillin resistant staphylococcus aureus (mrsa). antibiotics are sometimes used in combination in an attempt to prevent or delay the in vivo emerge ... | 2017 | 28735049 |
| vitek(®)2 cannot identify vancomycin-intermediate isolates: missing the opportunity for staphylococcus aureus therapy. | 2017 | 28734724 | |
| response to letter of k. singh, 'role of silver nitrate in the efficacy of hydrogen peroxide aerial decontamination systems' regarding s. ali et al. 'efficacy of two hydrogen peroxide vapour aerial decontamination systems for enhanced disinfection of meticillin-resistant staphylococcus aureus, klebsiella pneumoniae and clostridium difficile in single isolation rooms'. | 2017 | 28734723 | |
| characterization of a pvl-negative community-acquired methicillin-resistant staphylococcus aureus strain of sequence type 88 in china. | sequence type 88 community-acquired methicillin-resistant staphylococcus aureus (ca-mrsa) strain sr434, isolated from an outpatient with skin and soft tissue infection, was subjected to whole genome sequencing, antimicrobial susceptibility testing, mouse skin infection model and hemolysis analysis to identify its virulence and resistance determinants. mrsa strain sr434 is resistant to clindamycin, erythromycin and fosfomycin. four plasmids with resistance genes were identified in this strain, in ... | 2017 | 28734577 |
| phenotypic and genetic characteristics of fluoroquinolone- and methicillin-resistant staphylococcus aureus. | fluoroquinolone resistance in methicillin-resistant staphylococcus aureus (mrsa) has increased in recent years. the objective of this study was to characterise two mrsa populations, one susceptible to fluoroquinolones and other resistant identifying the clonal types and the differential characteristics of both mrsa populations. | 2017 | 28734506 |
| discrimination of bacteria by rapid sensing their metabolic volatiles using an aspiration-type ion mobility spectrometer (a-ims) and gas chromatography-mass spectrometry gc-ms. | the objective of our study was to investigate whether one may quickly and reliably discriminate different microorganism strains by direct monitoring of the headspace atmosphere above their cultures. headspace samples above a series of in vitro bacterial cultures were directly interrogated using an aspiration type ion mobility spectrometer (a-ims), which produced distinct profiles ("fingerprints") of ion currents generated simultaneously by the detectors present inside the ion mobility cell. data ... | 2017 | 28734362 |
| topological pattern for the search of new active drugs against methicillin resistant staphylococcus aureus. | molecular topology was used to develop a mathematical model capable of classifying compounds according to antimicrobial activity against methicillin resistant staphylococcus aureus (mrsa). topological indices were used as structural descriptors and their relation to antimicrobial activity was determined by using linear discriminant analysis. this topological model establishes new structure activity relationships which show that the presence of cyclopropyl, chlorine and ramification pairs at a di ... | 2017 | 28734246 |
| assessment of cultivable oral bacterial flora from important venomous snakes of india and their antibiotic susceptibilities. | snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of india. snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. the pathogens from the oral cavity of the snake tend to initiate an infection, resulting ... | 2017 | 28733908 |
| antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach. | to describe the current standards of care and major recent advances with regard to antimicrobial resistance (amr) and to give a prospective overview for the next 30 years in this field. | 2017 | 28733718 |
| role of sccmec type in resistance to the synergistic activity of oxacillin and cefoxitin in mrsa. | β-lactam antibiotics target penicillin-binding proteins (pbps) preventing peptidoglycan synthesis and this inhibition is circumvented in methicillin resistant staphylococcus aureus (mrsa) strains through the expression of an additional pbp, named pbp2a. this enzyme is encoded by the meca gene located within the staphylococcal chromosome cassette mec (sccmec) mobile genetic element, of which there are 12 types described to date. previous investigations aimed at analysing the synergistic activity ... | 2017 | 28733674 |
| a rare case of methicillin resistant staphylococcus aureus (mrsa) cerebral abscess secondary to conjunctivitis. | this case report discusses the rare association of cerebral abscess related to conjunctivitis in an otherwise healthy child. a 6 year old boy presented with conjunctivitis was treated with topical antibiotics and resolved after a week. conjunctival swab cultures grew mrsa. a month later he developed status epileptics and ct scans revealed a large cerebral abscess. he was treated with intravenous antibiotics which covered for mrsa, along with an incision and drainage for the cerebral abscess. pus ... | 2017 | 28733571 |
| α-toxin regulates local granulocyte expansion from hematopoietic stem and progenitor cells in staphylococcus aureus-infected wounds. | the immune response to staphylococcus aureus infection in skin involves the recruitment of polymorphonuclear neutrophils (pmns) from the bone marrow via the circulation and local granulopoiesis from hematopoietic stem and progenitor cells (hspcs) that also traffic to infected skin wounds. we focus on regulation of pmn number and function and the role of pore-forming α-toxin (at), a virulence factor that causes host cell lysis and elicits inflammasome-mediated il-1β secretion in wounds. infection ... | 2017 | 28733486 |
| seven new lignan glycosides from the branches of alangium kurzii craib var. laxifolium. | seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of alangium kurzii craib var. laxifolium. their structures were established by spectroscopic analysis and circular dichroism (cd) and x-ray analysis. the isolated compounds were evaluated for their antibacterial activities against staphylococcus aureus ci1011, streptococcus suis ci1608, salmonella gallinarum ci0912, enterococcus faecalis ci1304, aeromonas hydrophila ci1008, escherichia coli ci1 ... | 2017 | 28733150 |
| ultrasound assisted phytosynthesis of iron oxide nanoparticle. | the present work deals with the ultrasound assisted green synthesis of iron oxide nano particle using coriandrum sativum leaf extract as a reducing agent. the synthesized iron oxide nanoparticle was confirmed by uv spectra. the characterization was done to know more about morphology and size of the particle by sem analysis which shows spherical particles with size ranging from 20 to 90nm. the antimicrobial activity of the leaf extract and the synthesized nanoparticles was studied against the pat ... | 2017 | 28732967 |
| analysis of staphylococcus aureus cell viability, sublethal injury and death induced by synergistic combination of ultrasound and mild heat. | this study was designed to investigate the combined effects of ultrasound and mild heat on the viability of s. aureus in association with the cell membrane integrity and intracellular enzyme activity. cells were treated by ultrasound under 55°c for 3, 5, 7, 10, and 15min. the dynamic changes of s. aureus cell viability, sublethal injury and death were evaluated using flow cytometric assay. microscopies were applied to identify the morphological appearance, ultrastructure and topography of s. aur ... | 2017 | 28732925 |
| in situ reduction of silver nanoparticles by chitosan-l-glutamic acid/hyaluronic acid: enhancing antimicrobial and wound-healing activity. | spongy composites with silver nanoparticles (agnps) were synthesized by freeze-drying a mixture of silver nitrate (agno3) and chitosan-l-glutamic acid (cg) derivative loaded with hyaluronic acid (ha) solution. cg/agnp spongy composites had an interconnected porous structure and rough surfaces. when agnps (5-20nm) were immobilized on these spongy composites, agnp aggregation was dependent on agno3 concentration. the spongy composites exhibited good mechanical properties, swelling, and water reten ... | 2017 | 28732899 |
| future trends in the treatment of methicillin-resistant staphylococcus aureus (mrsa) infection: an in-depth review of newer antibiotics active against an enduring pathogen. | methicillin-resistant staphylococcus aureus (mrsa) continues to be a major public health problem. vancomycin and teicoplanin have been in clinical use for several decades but their drawbacks are well described. in the last 10 years, several antibiotics have been made available for clinical use. daptomycin and linezolid have been extensively used during this period. other agents such as ceftaroline, ceftobiprole, dalbavancin, oritavancin, tedizolid and telavancin have been approved by regulatory ... | 2017 | 28732783 |
| antimicrobial activity of disinfectants commonly used in the food industry in mexico. | disinfectants are widely used in food processing environments for microorganism control; their activity can vary according the microorganism and their used in the appropriated concentrations is vital. hence, the aim of this study was determined the effectiveness and minimum inhibitory concentration (mic) of 15 disinfectants commonly used in the food industry in mexico. | 2017 | 28732782 |
| long-acting water-stable organosilane agent and its sustained effect on reducing microbial load in an intensive care unit. | contaminated hospital surfaces contribute significantly to the transmission of health care-associated infections. although disinfectants reduce bioburden by up to 99%, bacterial growth can rebound within hours to precleaning levels. we tested the effectiveness of an innovative, long-acting water-stable organosilane (wso) to achieve sustained decreases in bioburden on hard surfaces. | 2017 | 28732741 |
| minocycline modulates nfκb phosphorylation and enhances antimicrobial activity against staphylococcus aureus in mesenchymal stromal/stem cells. | mesenchymal stromal/stem cells (mscs) have demonstrated pro-healing properties due to their anti-inflammatory, angiogenic, and even antibacterial properties. we have shown previously that minocycline enhances the wound healing phenotype of mscs, and mscs encapsulated in poly(ethylene glycol) and gelatin-based hydrogels with minocycline have antibacterial properties against staphylococcus aureus (sa). here, we investigated the signaling pathway that minocycline modulates in mscs which results in ... | 2017 | 28732530 |
| staphylococcus aureus prostatic abscess: a clinical case report and a review of the literature. | 2017 | 28732492 | |
| wrecking staph's rafts: staphylococcus aureus no longer unsinkable? | functional membrane microdomains (fmms) serve to spatially restrict and coordinate a diversity of cellular functions. flotillins serve as scaffolds within fmms, and in this issue of cell chemical biology, koch et al. (2017) show that disrupting staphylococcus aureus scaffolds via small molecules perturbs virulence gene expression and attenuates s. aureus virulence. | 2017 | 28732197 |
| the π configuration of the www motif of a short trp-rich peptide is critical for targeting bacterial membranes, disrupting preformed biofilms, and killing methicillin-resistant staphylococcus aureus. | tryptophan-rich peptides, being short and suitable for large-scale chemical synthesis, are attractive candidates for developing a new generation of antimicrobials to combat antibiotic-resistant bacteria (superbugs). although there are numerous pictures of the membrane-bound structure of a single tryptophan (w), how multiple trp amino acids assemble themselves and interact with bacterial membranes is poorly understood. this communication presents the three-dimensional structure of an eight-residu ... | 2017 | 28731688 |
| bioinspired and biomimetic agnps/gentamicin-embedded silk fibroin coatings for robust antibacterial and osteogenetic applications. | with the progressively increasing demand for orthopedic ti implants, the balance between two primary complications restricting implant applications is needed to be solved: the lack of bone tissue integration and biomedical device-associated infections (bai), where emergence of multiresistance bacteria make it worse. notably, a combination of silver nanoparticles (agnps) and a kind of antibiotic can synergistically inhibit bacterial growth, where a low concentration of agnps has been confirmed to ... | 2017 | 28731325 |
| adsorption of staphylococcus viruses s13' and s24-1 on staphylococcus aureus strains with different glycosidic linkage patterns of wall teichoic acids. | the group of phages belonging to the family podoviridae, genus p68virus, including staphylococcus viruses s13' and s24-1, are important because of their benefits in phage therapy against staphylococcus aureus infections. the o-glycosidic linkage patterns of wall teichoic acids (wtas) in s. aureus cell walls seem to be important for adsorption of this phage group. in this study, the adsorption of staphylococcus viruses s13' and s24-1 to s. aureus was examined using strains with modified wta glyco ... | 2017 | 28730979 |
| clinical characteristics and ultrasonographic findings of acute bacterial enterocolitis in children. | this study clarified the bacterial pathogens currently causing acute infectious enterocolitis (aie) in children and evaluated the clinical characteristics and ultrasonographic findings according to the different pathogens. | 2017 | 28730135 |
| clonal spread of methicillin-resistant staphylococcus aureus-t6065-cc5-sccmecv-agrii in a libyan hospital. | the aim of this study was to characterize 32 mrsa isolates recovered from wound specimens of patients in a hospital in tripoli, libya, during 2013. | 2017 | 28729209 |
| characterization of clinical isolates oxacillin-susceptible meca-positive staphylococcus aureus (os-mrsa) in china from 2009-2014. | the study aimed to investigate the prevalence and molecular characteristics of clinical oxacillin-susceptible meca-positive staphylococcus aureus (os-mrsa) isolates in china from july 2009 to june 2014. | 2017 | 28729204 |
| tedizolid inhibits muc5ac production induced by methicillin-resistant staphylococcus aureus in human airway epithelial cells. | the innate immune system plays an important role in early immunity against respiratory tract infection. although airway epithelial cells produce mucus to eliminate pathogens and irritants, hypersecretion of mucus is harmful for the host as it may cause airway obstruction and inhibit influx of antimicrobial agents. it has been reported that several antimicrobial agents have an immunomodulatory effect in vitro and in vivo, but little is known about whether tedizolid, a novel oxazolidinone, can mod ... | 2017 | 28729052 |
| the staphylococcus aureus fasii bypass escape route from fasii inhibitors. | antimicrobials targeting the fatty acid synthesis (fasii) pathway are being developed as alternative treatments for bacterial infections. emergence of resistance to fasii inhibitors was mainly considered as a consequence of mutations in the fasii target genes. however, an alternative and efficient anti-fasii resistance strategy, called here fasii bypass, was uncovered. bacteria that bypass fasii incorporate exogenous fatty acids in membrane lipids, and thus dispense with the need for fasii. this ... | 2017 | 28728970 |
| influence of staphylococcus aureus on outcomes after valvular surgery for infective endocarditis. | as staphylococcus aureus (sa) remains one of the leading cause of infective endocarditis (ie), this study evaluates whether s. aureus is associated with more severe infections or worsened outcomes compared to non-s. aureus (nsa) organisms. | 2017 | 28728556 |
| successful rescue combination of extracorporeal membrane oxygenation, high-frequency oscillatory ventilation and prone positioning for the management of severe methicillin-resistant staphylococcus aureus pneumonia complicated by pneumothorax: a case report and literature review. | to describe the experience of combination therapy with extracorporeal membrane oxygenation(ecmo), high-frequency oscillatory ventilation(hfov) and prone positioning in treating severe respiratory failure caused by community acquired methicillin resistant staphylococcus aureus(ca-mrsa). | 2017 | 28728546 |
| [pyogenic liver abscess: changes of organisms and consequences for diagnosis and therapy]. | liver abscess is a rare but potentially fatal disease with mortality rates of 2 - 12 %. the spectrum of causative microorganisms varies across the world and is changing due to increasing worldwide travel activity. as a result, previously less frequent pathogens must increasingly be considered in the differential diagnosis. the most common pathogens of liver abscess are so-called abscess streptococci, anaerobes and gram-negative bacteria such as escherichia coli and klebsiella pneumoniae. certain ... | 2017 | 28728202 |
| in vitro activity of telavancin against clinically important gram-positive pathogens from 69 u.s. medical centers (2015): potency analysis by u.s. census divisions. | a total of 8,072 gram-positive isolates collected from 69 medical centers among all 9 u.s. census divisions during the 2015 sentry antimicrobial surveillance program were included. telavancin had minimal inhibitory concentration (mic)50 and mic90 values of 0.03/0.06 μg/ml, respectively, against methicillin-susceptible (mssa) and methicillin-resistant staphylococcus aureus (mrsa). similar activity was also observed among coagulase-negative staphylococci (mic50/90, 0.03/0.06 μg/ml; 100.0% inhibite ... | 2017 | 28727951 |
| novel role of surfactant protein a in bacterial sinusitis. | chronic rhinosinusitis (crs) is a common inflammatory disorder of the upper airway characterized by chronic inflammation and significant sinonasal remodeling. crs is comprised of 2 major subgroups, based on whether polyps are present or absent. in some cases, it is characterized by colonization with opportunistic pathogens such as pseudomonas aeruginosa (pa), staphylococcus aureus, and other bacteria. the innate immune system of the sinonasal epithelium is the first line of defense against inhal ... | 2017 | 28727907 |
| antimicrobial resistance rates in gram-positive bacteria do not drive glycopeptides use. | surveillance data are considered essential to appropriate empiric antibiotic therapy and stewardship. the objective of this study was to determine if a change in the rates of antibiotic resistance impacts antibiotic use in european hospitals. glycopeptides use was selected to study the correlation between resistance rates and antibiotic use because of the restricted spectrum against resistant gram positive bacteria. pubmed, ecdc databases and national/regional surveillance systems were searched ... | 2017 | 28727741 |
| antibiotic that inhibits the atpase activity of an atp-binding cassette transporter by binding to a remote extracellular site. | antibiotic-resistant strains of staphylococcus aureus pose a major threat to human health and there is an ongoing need for new antibiotics to treat resistant infections. in a high throughput screen (hts) of 230 000 small molecules designed to identify bioactive wall teichoic acid (wta) inhibitors, we identified one hit, which was expanded through chemical synthesis into a small panel of potent compounds. we showed that these compounds target targ, the transmembrane component of the two-component ... | 2017 | 28727445 |
| antimicrobial effects of silver nanoparticles synthesized by fatsia japonica leaf extracts for preservation of citrus fruits. | due to their potent antimicrobial activity, silver nanoparticles (agnps) synthesized by biomass might be promising in food preservation, whereas effects of agnps on penicillium italicum-induced rot of citrus fruits have not been investigated. in this study, a novel agnps biosynthesis method was developed based on fatsia japonica leaf extracts. it was revealed that concentrations of leaf extracts, agno3 and nacl affected agnps yields and particle sizes obviously. under the optimized conditions (8 ... | 2017 | 28727146 |
| effect of experimentally increased protein supply to postpartum dairy cows on plasma protein synthesis, rumen tissue proliferation, and immune homeostasis. | the effect of experimentally increasing the postpartum protein supply on plasma protein synthesis, rumen tissue proliferation, and immune homeostasis was studied using 8 periparturient holstein cows in a complete randomized design. at calving, cows were assigned to abomasal infusion of water (ctrl) or casein (cas) in addition to a lactation diet. casein infusion was gradually decreased from 696 ± 1 g/d at +2 d relative to calving (drtc) to 212 ± 10 g/d at +29 drtc to avoid excessive supply. synt ... | 2017 | 28727010 |
| antimicrobial properties of selected copper alloys on staphylococcus aureus and escherichia coli in different simulations of environmental conditions: with vs. without organic contamination. | background: hospital equipment made from copper alloys can play an important role in complementing traditional methods of disinfection. aims of the study: the aim of this study was to assess the dynamics of the antimicrobial properties of selected copper alloys in different simulations of environmental conditions (with organic contamination vs. without organic contamination), and to test alternatives to the currently used testing methods. materials and methods: a modification of japanese standar ... | 2017 | 28726753 |
| epidemiology and clinical relevance of staphylococcus aureus intestinal carriage: a systematic review and meta-analysis. | recent data highlight the importance of screening more than one site for improving the detection of s. aureus colonization. intestinal carriage is frequently under-investigated and its clinical impact ought to be defined a better way. areas covered: this review and meta-analysis provide an updated overview of prevalence, characteristics and clinical significance of s. aureus intestinal carriage in different populations, both for methicillin-susceptible and -resistant s. aureus strains. expert co ... | 2017 | 28726558 |
| human milk oligosaccharide categories define the microbiota composition in human colostrum. | human milk oligosaccharides (hmos) are structurally diverse unconjugated glycans with a composition unique to each lactating mother. while hmos have been shown to have an impact on the development of infant gut microbiota, it is not well known if hmos also already affect milk microbial composition. to address this question, we analysed eleven colostrum samples for hmo content by high-pressure liquid chromatography and microbiota composition by quantitative pcr. higher total hmo concentration was ... | 2017 | 28726512 |
| spinal cord stimulator related infections: findings from a multicenter retrospective analysis of 2737 implants. | surgical site infection is a potential complication of spinal cord stimulator (scs) implantation. current understanding of the epidemiology, diagnosis, and treatment of these infections is based largely on small clinical studies, many of which are outdated. evidence-based guidelines for management of scs-related infections thus rely instead on expert opinion, case reports, and case series. in this study, we aim to provide a large scale retrospective study of infection management techniques speci ... | 2017 | 28726312 |
| robot guidance for percutaneous minimally invasive placement of pedicle screws for pyogenic spondylodiscitis is associated with lower rates of wound breakdown compared to conventional fluoroscopy-guided instrumentation. | postoperative wound healing can pose a problem in patients undergoing instrumented surgery for pyogenic spondylodiscitis. robotic guidance allows the minimally invasive placement of pedicle screws in the thoracolumbar spine. we assessed whether using this technique to perform minimally invasive surgery had an impact on wound healing in patients with pyogenic spondylodiscitis when compared to conventional open fluoroscopy-guided surgery. we reviewed charts of 206 consecutive patients who underwen ... | 2017 | 28726010 |
| isolation and characterization of antimicrobial compound from the stem-bark of the traditionally used medicinal plant adenium obesum. | medicinal plants constitute a natural reservoir for medicines worldwide. they serve mainstream therapeutics and are central in folklore medicine. in case of adenium obesum (lav, apocynaceae), indigenous people of oman use it for the treatment of venereal diseases, wounds, skin diseases, headaches, muscle pain as well as joint pain; yet, the active ingredients have not been classified. to screened the antioxidant and antimicrobial activities of an identified compound that we isolated from the hig ... | 2017 | 28725623 |
| chemical constituents of helichrysum italicum (roth) g. don essential oil and their antimicrobial activity against gram-positive and gram-negative bacteria, filamentous fungi and candida albicans. | the aerial parts of helichrysum italicum (roth) g. don were subjected to hydrodistillation to obtain essential oils which had been analyzed by gas chromatography and gas chromatography coupled with mass spectrometry and tested for antimicrobial activity against 12 bacteria, two yeasts and four fungi by agar diffusion method. the essential oil yielded 0.44% (v/w) and 67 compounds accounting for 99.24% of the oil were identified with a high content of oxygenated sesquiterpenes (61.42%). the most o ... | 2017 | 28725151 |
| a case of primary bacterial pericarditis with recurrent cardiac tamponade. | cardiac tamponade is an important and potentially lethal complication of acute pericarditis. however, recurrence of cardiac tamponade is rare when it is treated appropriately. we present a 49-year-old man with bacterial pericarditis and recurrent cardiac tamponade, which was caused by the rupture of an upper part of the left atrium (la). according to the autopsy findings, bacteremia from staphylococcus aureus developed on a substrate of poorly controlled diabetes mellitus and spread to the peric ... | 2017 | 28724847 |
| the role of antibiotics in modulating virulence in staphylococcus aureus. | staphylococcus aureus is often involved in severe infections, in which the effects of bacterial virulence factors have great importance. antistaphylococcal regimens should take into account the different effects of antibacterial agents on the expression of virulence factors and on the host's immune response. a pubmed literature search was performed to select relevant articles on the effects of antibiotics on staphylococcal toxin production and on the host immune response. information was sorted ... | 2017 | 28724662 |
| accurate detection of methicillin-resistant staphylococcus aureus in mixtures utilizing single bacterial duplex droplet digital pcr. | accurate and rapid identification of methicillin-resistant staphylococcus aureus (mrsa) is needed to screen mrsa carriers and improve treatment. the current widely used duplex pcr methods are not able to differentiate mrsa from the co-existence of methicillin-susceptible s. aureus (mssa) and other methicillin-resistant staphylococci in this study, we aimed to develop a direct method for accurate and rapid detection of mrsa in clinical samples from open environments, such as nasal swab. the new m ... | 2017 | 28724560 |
| methicillin-resistant staphylococcus aureus emerged long before the introduction of methicillin into clinical practice. | the spread of drug-resistant bacterial pathogens poses a major threat to global health. it is widely recognised that the widespread use of antibiotics has generated selective pressures that have driven the emergence of resistant strains. methicillin-resistant staphylococcus aureus (mrsa) was first observed in 1960, less than one year after the introduction of this second generation beta-lactam antibiotic into clinical practice. epidemiological evidence has always suggested that resistance arose ... | 2017 | 28724393 |
| the nucleoid occlusion factor noc controls dna replication initiation in staphylococcus aureus. | successive division events in the spherically shaped bacterium staphylococcus aureus are oriented in three alternating perpendicular planes. the mechanisms that underlie this relatively unique pattern of division and coordinate it with chromosome segregation remain largely unknown. thus far, the only known spatial regulator of division in this organism is the nucleoid occlusion protein noc that inhibits assembly of the cytokinetic ring over the chromosome. however, noc is not essential in s. aur ... | 2017 | 28723932 |
| identification of antipneumococcal molecules effective against different streptococcus pneumoniae serotypes using a resazurin-based high-throughput screen. | streptococcus pneumoniae is a major human pathogen, causing around 1.6 million deaths worldwide each year. by optimizing a resazurin-based assay to detect s. pneumoniae growth in 384-well microplates, we developed a new high-throughput screening (hts) system for the discovery of antipneumococcal molecules, which was unsuccessful using conventional absorbance measurements. before applying our protocol to a large-scale screen, we validated the system through a pilot screen targeting about 7,800 bi ... | 2017 | 28723269 |
| antibiotic resistance in young children in kilosa district, tanzania 4 years after mass distribution of azithromycin for trachoma control. | mass administration of azithromycin (mda) is integral to trachoma control. recent studies suggest that mda may increase drug-resistant pathogens, yet findings from prior studies suggest little long-term impact on resistance. this disparity may be linked to differences in pre-mda community-level resistance patterns. we describe carriage prevalence and antibiotic resistance patterns for streptococcus pneumoniae (spn) (nasopharyngeal swab collection), staphylococcus aureus (sa) (nasopharyngeal swab ... | 2017 | 28722638 |
| multidrug-resistant microorganisms colonizing lower extremity wounds in patients in a tertiary care hospital, lima, peru. | multidrug-resistant organism (mdro) infections cause high morbidity and mortality, and high costs to patients and hospitals. the study aims were to determine the frequency of mdro colonization and associated factors in patients with lower-extremity wounds with colonization. a cross-sectional study was designed during november 2015 to july 2016 in a tertiary care hospital in lima, peru. a wound swab was obtained for culture and susceptibility testing. mdro colonization was defined if the culture ... | 2017 | 28722595 |
| molecular epidemiology of staphylococcus aureus skin and soft tissue infections in the lao people's democratic republic. | this is the first report of the molecular epidemiology of staphylococcus aureus from skin and soft tissue infections (ssti) in laos. we selected a random sample of 96 s. aureus ssti isolates received by the microbiology laboratory, mahosot hospital, vientiane, between july 2012 and june 2014, including representation from seven referral hospitals. isolates underwent susceptibility testing by clinical and laboratory standards institute methods, spa typing and dna microarray analysis, with whole g ... | 2017 | 28722566 |
| in vitro evaluation of chitosan-coated liposome containing both coenzyme q10 and alpha-lipoic acid: cytotoxicity, antioxidant activity, and antimicrobial activity. | chitosan-coated liposome containing both coenzyme q10 and alpha-lipoic acid (ccal) was a novel multifunctional nano delivery system exhibited long-term stability at room temperature and high encapsulation efficiency. which containing two kinds of antioxidants (coenzyme q10 and alpha-lipoic acid) and two antibacterial agents (chitosan and alpha-lipoic acid). however, the further biocompatibility, such as cytotoxicity and antioxidant activity, and antimicrobial activity of ccal, has not been syste ... | 2017 | 28722258 |
| bacteria antibiotic resistance: new challenges and opportunities for implant-associated orthopedic infections. | there has been a dramatic increase in the emergence of antibiotic-resistant bacterial strains, which has made antibiotic choices for infection control increasingly limited and more expensive. in the u.s. alone, antibiotic-resistant bacteria cause at least 2 million infections and 23,000 deaths a year resulting in a $55-70 billion per year economic impact. antibiotics are critical to the success of surgical procedures including orthopedic prosthetic surgeries, and antibiotic resistance is occurri ... | 2017 | 28722231 |
| antimicrobial activity of selected polyphenols and capsaicinoids identified in pepper (capsicum annuum l.) and their possible mode of interaction. | antimicrobial activity of pepper polyphenols and capsaicinoids (coumarin, caffeic acid, narangin, kaempferol, rutin, quercetin, capsaicin, and dihydrocapsaicin) against 13 pathogen bacteria and three beneficial strains was studied using the disk diffusion and microdilution methods. in general, phenolic compounds had the most important activity with the highest inhibition zones obtained with caffeic acid (3.5-20.5 mm), quercetin (4.75-3.5 mm), and kaempferol (7-14 mm). in the determination of the ... | 2017 | 28721659 |
| contribution of echocardiography in the diagnosis of definitive infective endocarditis: the infectious disease specialist's point of view. | in 1994, the original duke criteria introduced the usefulness of echocardiography for the diagnosis of definitive infective endocarditis (ie). recently, the european society of cardiology (esc) highlighted the need of complementary imaging to support the diagnosis of embolic events and cardiac involvement when echocardiography findings are negative or doubtful. we decided to study the usefulness of transthoracic and transesophageal echocardiography (tte/tee) for the diagnosis of definitive ie in ... | 2017 | 28721638 |
| bacterial attachment and biofilm formation on surfaces are reduced by small-diameter nanoscale pores: how small is small enough? | prevention of biofilm formation by bacteria is of critical importance to areas that directly affect human health and life including medicine, dentistry, food processing and water treatment. this work showcases an effective and affordable solution for reducing attachment and biofilm formation by several pathogenic bacteria commonly associated with foodborne illnesses and medical infections. | 2015 | 28721236 |
| effect of a lotion containing the heat-treated probiotic strain lactobacillus johnsonii ncc 533 on staphylococcus aureus colonization in atopic dermatitis. | staphylococcus aureus dominates the skin microbiota in patients with atopic dermatitis (ad), with bacterial loads correlating with disease severity. the aim of this exploratory study was to investigate the effect of a cosmetic lotion containing heat-treated lactobacillus johnsonii ncc 533 (ht la1) on s. aureus colonization in ad patients. | 2017 | 28721083 |
| stimulated phase-shift acoustic nanodroplets enhance vancomycin efficacy against methicillin-resistant staphylococcus aureus biofilms. | bacterial biofilms on the surface of prostheses are becoming a rising concern in managing prosthetic joint infections. the inherent resistant features of biofilms render traditional antimicrobial therapy unproductive and revision surgery outcomes uncertain. this situation has prompted the exploration of novel antimicrobial strategies. the synergy of ultrasound microbubbles and vancomycin has been proposed as an efficient alternative for biofilm eradication. the purpose of this study was to evalu ... | 2017 | 28721044 |
| determining optimal dosing regimen of oral administration of dicloxacillin using monte carlo simulation. | dicloxacillin, a semisynthetic isoxazolyl penicillin, exhibits antimicrobial activity against a wide variety of gram-positive bacteria, as well as stability against penicillinases and low level of toxicity. the objective of this study was to obtain optimal dosing regimen of oral administration of dicloxacillin by analyzing the pharmacokinetic (pk) index in healthy volunteers and in vitro antibacterial activity by using monte carlo simulation. | 2017 | 28721014 |
| isolation and characterization of lactic acid bacteria from traditional pickles of himachal pradesh, india. | a total of 15 isolates of lactic acid bacteria (lab) were isolated from traditional pickles of rural and urban areas of himachal pradesh. these isolates were identified as enterococcus faecalis (7), lactobacillus plantarum (3), pediococcus pentosaceus (2), leuconostoc mesenteroides (1), lactococcus lactis (1) and enterococcus sp. (1) on the basis of morphological, biochemical and 16s rdna sequence analysis. all the labs produced exopolysaccharides, have antibiotic susceptibility, and possess act ... | 2017 | 28720951 |
| pseudomonas aeruginosa alters staphylococcus aureus sensitivity to vancomycin in a biofilm model of cystic fibrosis infection. | the airways of cystic fibrosis (cf) patients have thick mucus, which fosters chronic, polymicrobial infections. pseudomonas aeruginosa and staphylococcus aureus are two of the most prevalent respiratory pathogens in cf patients. in this study, we tested whether p. aeruginosa influences the susceptibility of s. aureus to frontline antibiotics used to treat cf lung infections. using our in vitro coculture model, we observed that addition of p. aeruginosa supernatants to s. aureus biofilms grown ei ... | 2017 | 28720732 |
| neonatal acute paronychia. | paronychia is defined as infection afflicting the eponychial nail folds of the hand or foot. such infections are rarely reported in the perinatal age group, and not previously described in a neonate younger than 2 weeks. trauma resulting in inoculation of the nail fold is the most common predisposing factor to paronychia. oral trauma in the pediatric population from finger sucking predisposes this population to a different set of bacterial pathogens than adults. contamination can progress to inf ... | 2017 | 28720045 |
| neonatal lemierre syndrome: youngest reported case and literature review. | a previously healthy 5-week-old female was admitted for sepsis secondary to methicillin-resistant staphylococcus aureus (mrsa) bacteremia. after several days of hospitalization, she experienced acute decompensation in mental status despite having received targeted antibiotic therapy. imaging revealed left peritonsillar/parapharyngeal space abscess, left venous thrombophlebitis of the internal jugular vein, and septic emboli of the lungs and brain consistent with lemierre syndrome. bedside needle ... | 2017 | 28719983 |
| disease burden, characteristics, and outcomes of methicillin-resistant staphylococcus aureus bloodstream infection in hong kong. | we aimed to describe disease burden, characteristics, and outcomes of methicillin-resistant staphylococcus aureus (mrsa) bloodstream infection (bsi) in hong kong. a retrospective, observational study was conducted in 26 hong kong public hospitals between january 2010 and december 2012. the primary outcome measures were 30-day mortality rate and infection-related hospital cost. of 1133 patients reviewed, 727 (64.17%) were male, 1075 (94.88%) had health care-associated community-onset and 44 (3.88 ... | 2017 | 28719790 |
| isolation and in vitro evaluation of bacteriophages against mdr-bacterial isolates from septic wound infections. | multi-drug resistance has become a major problem for the treatment of pathogenic bacterial infections. the use of bacteriophages is an attractive approach to overcome the problem of drug resistance in several pathogens that cause fatal diseases. our study aimed to isolate multi drug resistant bacteria from patients with septic wounds and then isolate and apply bacteriophages in vitro as alternative therapeutic agents. pus samples were aseptically collected from rajiv gandhi institute of medical ... | 2017 | 28719657 |
| characterization of candidate probionts isolated from human breast milk. | this study was designed to isolate and identify the potential probionts present in 32 healthy mothers' breast milk. microbial culture media and 16srrna sequencing were used to isolate and identify the bacteria and all isolates were analyzed for their antagonistic potential, resistance to acidic ph, bile salts and survival under simulated gastric and intestinal conditions. the colonization potential was further assessed based on adherence to human enterocyte-like caco-2 cell lines. the breast mil ... | 2017 | 28719350 |
| infective endocarditis in french west indies: a 13-year observational study. | we conducted an observational study to describe the characteristics of infective endocarditis (ie) in french west indies (fwi) and to identify variables associated with in-hospital case fatality. the records of the patients admitted for ie to the university hospital of martinique between 2000 and 2012 were collected using an electronic case report form. only duke-li definite cases were considered for this analysis. variables associated with in-hospital mortality were tested using univariate logi ... | 2017 | 28719311 |
| bacteriology of diabetic foot in tertiary care hospital; frequency, antibiotic susceptibility and risk factors. | diabetic foot being one of the frequent and disabling complications of diabetes. in view of widespread regional variation in causative organisms and antimicrobial susceptibility, the current study aimed to determine frequency of causative organisms, their antimicrobial susceptibility and associated risk factors. | 2017 | 28718238 |
| septic arthritis associated with systemic sepsis. | septic arthritis presents with good joint function, but sometimes leads to poor outcomes. concurrent systemic sepsis has been regarded as the poor outcome, and the exact cause remains unclear. this paper was performed to identify factors associated with concurrent systemic sepsis and to research results to predict poor outcomes in patients with septic arthritis. | 2017 | 28717843 |
| community-acquired methicillin-resistant staphylococcus aureus carriage rate and antimicrobial susceptibility in a tertiary center, iran. | this study was aimed to determine frequency and antimicrobial susceptibility of community-acquired methicillin-resistant staphylococcus aureus (ca-mrsa) among colonized patients in outpatient status. | 2017 | 28717368 |
| tetracycline resistance phenotypes and genotypes of coagulase-negative staphylococcal isolates from bubaline mastitis in egypt. | this study was devoted to elucidate the tetracycline resistance of coagulase-negative staphylococci (cns) derived from normal and subclinical mastitic (scm) buffaloes' milk in egypt. | 2017 | 28717325 |
| molecular characterization of antibiotic-resistant staphylococcus aureus from livestock (bovine and swine). | the aim of this study was to figure the prevalence, phenotypic and genotypic antibiotic resistance (ar) pattern of staphylococcus aureus isolated from bovine and swine nares. | 2017 | 28717309 |
| prevalence of methicillin-resistant staphylococcus aureus skin and nasal carriage isolates from bovines and its antibiogram. | this study was conducted to determine the prevalence of methicillin-resistant staphylococcus aureus (mrsa) in cattle and buffalo and to study their antibiotic resistance pattern. | 2017 | 28717308 |
| a novel pathogen capturing device for removal and detection. | a simple technique that employs an antibody coated polydimethylsiloxane tube is used for effective capturing of bloodborne and foodborne pathogens. by recirculating the entire sample through the antibody coated tube, accumulation of target pathogens is achieved, thereby delivering a higher concentration of pathogens in a small volume. the described method can provide an effective and economical solution to microbiology techniques that rely on enrichment, thereby expediting diagnostics. using thi ... | 2017 | 28717239 |
| acetylsalicylic acid differentially limits the activation and expression of cell death markers in human platelets exposed to staphylococcus aureus strains. | beyond their hemostatic functions, platelets alter their inflammatory response according to the bacterial stimulus. staphylococcus aureus is associated with exacerbated inflammation and thrombocytopenia, which is associated with poor prognosis during sepsis. acetylsalicylic acid and statins prevent platelet aggregation and decrease the mortality rate during sepsis. therefore, we assessed whether these two molecules could reduce in vitro platelet activation and the inflammatory response to s. aur ... | 2017 | 28717145 |
| new delhi metallo-beta-lactamase (ndm-1)-producing klebsiella pneumoniae isolated from a burned patient. | background infections affecting burn patients are frequently caused by staphylococcus aureus, pseudomonas aeruginosa, and enterobacteriaceae species. infections with these pathogens have become increasingly difficult to treat due to evolving antibiotic resistance mechanisms, including the production of carbapenemases. case report the present case report describes the evolution of a burn patient with polymicrobial healthcare-associated burn infections, including a bloodstream infection due to an ... | 2017 | 28717120 |
| tandem amplification of the staphylococcal cassette chromosome mec element can drive high-level methicillin resistance in methicillin-resistant staphylococcus aureus. | hospital-associated methicillin-resistant staphylococcus aureus (mrsa) strains typically express high-level, homogeneous (hor) β-lactam resistance, whereas community-associated mrsa (ca-mrsa) more commonly express low-level heterogeneous (her) resistance. expression of the hor phenotype typically requires both increased expression of the meca gene, carried on the staphylococcal cassette chromosome mec element (sccmec), and additional mutational event(s) elsewhere on the chromosome. here the oxac ... | 2017 | 28717043 |
| a human biofilm-disrupting monoclonal antibody potentiates antibiotic efficacy in rodent models of both staphylococcus aureus and acinetobacter baumannii infections. | many serious bacterial infections are antibiotic-refractory due to biofilm formation. a key structural component of biofilm is extracellular dna which is stabilized by bacterial proteins, including those from the dnabii family. trl1068 is a high affinity human monoclonal antibody against a dnabii epitope conserved across both gram-positive and gram-negative bacterial species. in the current study, the efficacy of trl1068 for disruption of biofilm was demonstrated in vitro in the absence of antib ... | 2017 | 28717038 |