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bg level and body weight at initial hospital visit correlate well with subsequent development of diabetic retinopathy. 20143948643
initiation and promotion in young and old animals. implications for human tumour formation.the significance of ageing in experimental skin carcinogenesis and on the manifestation of tumour formation in man was studied. initiation with the carcinogenic hydrocarbon 7,12-dimethylbenz [a]anthracene and promotion with croton oil in mouse skin showed that tumour formation was unchanged when promotion was delayed 3, 10, 23 or 43 weeks in comparison with that in untreated animals of the same age. the sensitivity to carcinogen treatment of animals over 71 weeks of age was less than that of ani ...19853938448
influence of benzodiazepine (diazepam) by single and repeated treatment on the growth of tetrahymena.diazepam at 10(-7) m stimulated considerably the growth of tetrahymena. the growth rate increase was still demonstrable after 3 days (after about 15 generations) and was even greater than initially. a second treatment with diazepam did not furthermore increase the growth rate.20143937525
identification of 5-acetamido-3,5,7,9-tetradeoxy-7-[(r)-3-hydroxybutyramido]-l- glycero-l-manno-nonulosonic acid as a component of bacterial polysaccharides. 19853933831
studies on microsomal azoreduction. n,n-dimethyl-4-aminoazobenzene (dab) and its derivatives.the azoreduction of n,n-dimethyl-4-aminoazobenzene (dab) and n-methyl-4-amino-azobenzene (mab) by rat liver microsomes was investigated. it was shown that measurement of azoreduction of dab and structurally related azo dyes by the conventional method of substrate disappearance required an anaerobic environment since n-demethylated and ring-hydroxylated metabolites formed aerobically interfered with the assay system, producing quantitatively inaccurate results. oxygen partially, but not totally, ...19853929790
[primary transport of acute patients. optimal use of rescue resources exemplified by the canton of graubünden]. 20113927607
a 2,4-dichlorophenyl diazonium-based method for total bilirubin without interference from indican in uremic sera.comparison of total bilirubin quantification by a 2,4-dichlorophenyl diazonium method (2,4-dcpd) with a jendrassik-grof type of method showed excellent correlation for randomly selected sera. however, sera from uremic patients on chronic hemodialysis showed a marked positive bias for the 2,4-dcpd result as compared with the jendrassik-grof result. the mean difference was 5.3 mg/l, and resulted in about 20% of the hemodialysis patients having bilirubin values greater than 13 mg/l, the upper limit ...20133924443
a 2,4-dichlorophenyl diazonium-based method for total bilirubin without interference from indican in uremic sera.comparison of total bilirubin quantification by a 2,4-dichlorophenyl diazonium method (2,4-dcpd) with a jendrassik-grof type of method showed excellent correlation for randomly selected sera. however, sera from uremic patients on chronic hemodialysis showed a marked positive bias for the 2,4-dcpd result as compared with the jendrassik-grof result. the mean difference was 5.3 mg/l, and resulted in about 20% of the hemodialysis patients having bilirubin values greater than 13 mg/l, the upper limit ...20133924443
bactericidal properties of a new water disinfectant.the n-chloramine compound 3-chloro-4,4-dimethyl-2-oxazolidinone (agent i) has been compared with calcium hypochlorite as to its efficacy as a bactericide for the treatment of water. the study included concentration, contact time, ph, temperature, and water quality as controlled variables. the species of bacteria tested were staphylococcus aureus, pseudomonas aeruginosa, and shigella boydii. in general, for highly pure, demand-free water, calcium hypochlorite was the more rapid disinfectant at a ...19853922300
[preparation of temporary bridges: not new--but different!]. 20143912813
[significance of isolating shigella under epidemiological circumstances]. 19853911318
[the renin-angiotensin system and regulation of arterial pressure in middle-aged and aged hypertensive patients]. 20143911314
photochemical modifications of lac repressor: effect of effectors binding on tryptophan photooxidation. 19853911222
mechanism of sbcb-suppression of the recbc-deficiency in postreplication repair in uv-irradiated escherichia coli k-12.the mechanism by which an sbcb mutation suppresses the deficiency in postreplication repair shown by recb recc mutants of escherichia coli was studied. the presence of an sbcb mutation in uvra recb recc cells increased their resistance to uv radiation. this enhanced resistance was not due to a suppression of the minor deficiency in the repair of dna daughter-strand gaps or to an inhibition of the production of dna double-strand breaks in uv-irradiated uvra recb recc cells; rather, the presence o ...19853911022
n-methyl-l-glutamate synthase. 19853911004
[the royal morocco academy]. 20133910181
determination of nanogram quantities of vanadium in biological material by isotope dilution thermal ionization mass spectrometry with ion counting detection. 19853907412
[3-year study of shigellosis epidemic in rwanda, central africa. problems of public health and bacteriological aspects].since 1979, the lakes region (kivu in zaïre, western uganda, rwanda, burundi) has been stricken by a bacillary dysentery epidemic at s. dysenteriae type 1. supposed to be extinct since the 1950s., this bacillus has revealed a very noticeable virulence as well by the number of registered cases (524/100.000 in 1983 at ruhengeri-rwanda) as its fast break through. demographic density (from 400 to 600/km2) has played an important role and has facilitated the transition toward epidemicity. systematic ...19853906345
comparison of beta enolase and myoglobin as histological markers of rhabdomyosarcoma.a comparative study of beta enolase and myoglobin as markers of muscle differentiation in rhabdomyosarcoma was carried out, using an immunoperoxidase peroxidase antiperoxidase technique. material from 26 cases of childhood rhabdomyosarcoma was studied and subdivided into embryonal and alveolar types. positive cytoplasmic staining for beta enolase was seen in 85% of tumours studied (91% alveolar, 79% embryonal), whereas positive staining for myoglobin was detected in only 69% of tumours (82% alve ...20133905869
[historical significance of the achievements of medicine and public health in world war ii 1941-1945]. 20143900561
shigella septicemia in elderly patients. 19853899990
epidemiology of shigella boydii serotype 2, a strain indigenous to spain. 19853899639
[detection of shigella antigens in the feces of patients with acute intestinal diseases using a coagglutination reaction].a total of 113 patients with acute intestinal diseases have been examined with the use of the coagglutination test. 84.95% of the patients showed the presence of different shigella antigens. in patients with bacteriologically confirmed dysentery the corresponding shigella antigens were detected in 96.97% of cases in s. sonnei dysentery, in 90% of cases in s. flexneri dysentery, in 75% of cases in s. newcastle dysentery and in 100% of bases in s. boydii dysentery. in 81.6% of patients with acute ...19853892986
[shigella serotypes isolated july-october 1983 and their antibiotic sensitivity].twenty four strains of shigella were isolated from the stool of patients who had been admitted to the hospital with the complaint of diarrhea. of these, 17 were found to be sh. flexneri, and 7 sh. boydii. antibiotic susceptibility tests indicated that all of the 24 isolates probably had multiple resistance factors. twenty three of 24 strains were found to be resistant to ampicillin. this may be important from a therapeutic point of view.19853892249
studies of metabolites in diarrheal stool specimens containing shigella species by frequency-pulsed electron capture gas-liquid chromatography.eleven diarrheal stool specimens and 10 control stool specimens from cairo, egypt, were studied by frequency-pulsed electron capture gas-liquid chromatography (fpec-glc). four cases involving shigella sonnei, three cases involving shigella boydii, and four cases involving shigella flexneri were studied. the aqueous stools were centrifuged, extracted with organic solvents, and derivatized to form specific electron-capturing derivatives of carboxylic acids, alcohols, hydroxy acids, and amines. ana ...19853886695
plaque formation by virulent shigella flexneri.an in vitro tissue culture plaque assay was developed to investigate the intracellular replication and intercellular spread of virulent shigellae. shigella plaques were formed in hela cell monolayers in the presence of an agarose overlay containing tissue culture medium and gentamicin, which eliminated extracellular bacterial growth. microscopically, the plaques were characterized by a central area of dead host cells surrounded by cells infected with shigellae. cells further away from the plaque ...19853884506
cranial ultrasound and clinical studies in preterm infants.serial ultrasound imaging of the brain was used to determine the ventricular index (vi), and the ratio (vr) of the vi to the cranial hemidiameter during the nursery course and first year post-term in preterm infants of less than 33 weeks gestation. twenty-nine of the infant survivors with no intracranial hemorrhage or major medical complication during their nursery course composed group 1. twenty-two survivors with intracranial hemorrhage unassociated with early ventricular dilation composed gro ...20133881581
addition of three new serotypes of shigella boydii to the shigella schema.no new serotypes have been added to the shigella schema since 1958, although several provisional serotypes have been described. we conducted biochemical and serological studies on three provisional shigella boydii serotypes. four strains of serotype 2710-54 from four widely separated countries, 7 strains of serotype 3615-53 from three different countries, and 31 strains of serotype 1344-78 (e10163) from six different countries were included. reactions of all three serotypes were consistent with ...19853881469
role of the posterior capsule in the prevention of postoperative bacterial endophthalmitis: experimental primate studies and clinical implications.the posterior capsule has an important effect on the risk of postoperative bacterial endophthalmitis. in order to investigate whether the posterior capsule inhibited the spread of infection into the vitreous we performed extracapsular cataract extraction in both eyes of 10 primates. in one eye of each primate the posterior capsule was left intact and in the other eye a large posterior capsulectomy was performed. when the anterior chambers were challenged with equivalent inocula of staphylococcus ...19853877524
protein loss of bovine dental enamel during in-vitro subsurface demineralization.a chemical system based on the dialysis principle was used to study protein loss of dental enamel during demineralization with an acetic-acid buffer solution containing calcium and phosphate, in which the fluoride-ion activity was kept constant. this resulted in a subsurface lesion, with a depth of about 130 microns. after demineralization, protein material was isolated from the demineralization solution. u.v. spectra of the protein showed strong absorbance between 240 and 300 nm. amino-acid com ...19853865639
[health behavior and self care: postulations and theories in health sociology]. 20133864276
[nonocclusive ischemic enteropathy--a rare cause of ileus].the cause for a nonocclusive ischemic enteropathy seems to be a low cardiac output syndrome. there are often signs of a paralytic intestinal obstruction. parameters of the blood chemistry offer no conclusive data. the angiogram of the mesenteric vessels demonstrates extensive arterial vasoconstriction as well as an obstructed venous outflow. experimental findings disclose that this venous obstruction may be a result of an ischemic contracture in the course of a low flow state. this rigor initiat ...20133840557
[multiple breast metastasis of cutaneous malignant melanoma]. 20133838028
antimicrobial activities of some flavonoid compounds.6 flavonoid compounds, namely kaempferol, quercetin, myricetin, rutin, naringin, and formononetin were separated from different plant materials. they were identified using column and paper chromatography techniques, and physicochemical methods were applied to determine their structure. isolated flavonoids were tested for their antimicrobial property against different bacterial and fungal strains as test organisms.20133811648
[an attempt to create a factorial model of the epizootic process in sheep infected with s. abortus ovis].experiments were carried out to build up a factorial model with a group of sheep at different age in an infected region. studied were the aspects of the disease as caused by salmonella abortus ovis alone and in combination with chl. ps. var. ovis. it was found that the factorial model can explain sufficiently well (77.22 per cent) the discussed system--the epizootic process with year-old females and sheep affected with pure and mixed infection. the epizootic process with a mixed infection in the ...19863811206
the cutting diathermy and drain tracts. 20133810377
[glomerulonephritis following infections]. 20133795528
efficacy of alcohol-based hand rinses under frequent-use conditions.fifty volunteers randomly assigned to one of five hand washing agents (10 subjects per agent)--a nonantiseptic liquid soap (control), an antiseptic hand rinse containing 60% isopropyl alcohol (ipa) with emollients (alc a), an antiseptic hand rinse containing 70% ipa and 0.5% chlorhexidine gluconate with emollients (alc b), an antiseptic containing 4% chlorhexidine gluconate and 4% ipa (chg), and 70% ipa--washed their hands 15 times per day for 5 days under supervision by using a standardized tec ...20133789690
pulmonary toxoplasmoma presenting as obstructive pneumonia. 20133787527
laser-assisted vasal anastomosis in the rat and man.in order to study the efficacy of laser-assisted vasal anastomosis (lava), a microscopic carbon dioxide surgical laser (xanar) was utilized in the anastomoses of human vas deferens in vitro and the sprague-dawley rat vas deferens in vivo. the longitudinal tensile and internal hydrostatic pressure strengths of laser-assisted vasal anastomoses were compared to conventional microsurgical suture anastomoses in the human vas deferens. the lava group had a greater mean internal hydrostatic pressure st ...19863773082
further validation of the problem inventory for adolescent girls: comparing caucasian and black delinquents and nondelinquents. 20133771896
bacteriological methods in diagnosis of tuberculous meningitis. 20073771495
midazolam in the intensive care unit. 20103769775
[establishment of a spontaneously transformed human fetal lung cell line and its biological characteristics].a spontaneously transformed human fetal lung cell line (hflt) was derived from a human fetal lung diploid fibroblast cell line (2bs) by continuous culture. the biological characteristics of this cell line were studied and compared with those of 2bs cells. accompanying the morphological alteration, the growth rate of the transformed cell was accelerated and the maximum cell density was increased. the anchorage-independent growth was shown by its ability to form colonies in soft agar. the collagen ...19863769747
antiprotease capacity in acute pancreatitis.serial measurements of circulating antiproteases were carried out on 42 consecutive patients admitted with acute pancreatitis. in the 7 days following admission the serum levels of alpha 1 antitrypsin (alpha 1 at), alpha 1 antichymotrypsin (alpha 1 act) and the trypsin inhibitory capacity (tic) increased by more than 300 per cent. the serum concentration of alpha 2 macroglobulin (alpha 2 m) alone showed a decline which was most profound in those patients with severe acute pancreatitis. initial e ...20103768647
change of blood pressure over five years in childhood and adolescence.we compared blood pressure (bp) values, measured at a five year interval, in 2,777 boys and girls aged 4-18 years. bp values were converted into height and sex adjusted standard deviation unit scores. correlation coefficients were significant but low for systolic bp score: 0.19 in boys and 0.15 in girls, and were even lower for diastolic bp score. these correlations are weaker than those observed for overall bp values (boys: 0.33, girls: 0.23), weight (0.82, 0.75) and height (0.87, 0.80). the pr ...20133757275
ovarian heterologous sertoli-leydig cell tumors with gastrointestinal-type epithelium. an immunohistochemical analysis.eight ovarian heterologous sertoli-leydig cell tumors containing gastrointestinal-type cells, including two tumors that contained carcinoids, were stained for argyrophilia and argentaffinity; in addition, these specimens were stained by immunohistocytochemical techniques for the demonstration of chromogranin, serotonin, and a variety of peptide hormones. intestinal- and gastric-type epithelial and carcinoid cells within the tumors were focally argyrophilic and chromogranin-positive, but only int ...20133754727
[sexually transmissible diseases in victims of sexual assault]. 20133754312
1,25-dihydroxyvitamin d3 treatment results in increased choline acetyltransferase activity in specific brain nuclei.to better understand the role of 1,25-dihydroxyvitamin d3 [1,25-(oh)2d3] in brain function, the level of calcium-binding protein (cabp) and the activities of choline acetyltransferase (cat) and monoamine oxidase were measured in discrete brain nuclei of vitamin d-deficient and -replete male rats. the nuclei sampled were those in which receptors for 1,25-(oh)2d3 and/or vitamin d-dependent cabp have been localized. significant elevations in cat activity were found in the arcuatemedian eminence and ...19863753932
establishment of passive hemagglutination assay (pha) system for anti-hbc in plasma.a sensitive and specific assay system for anti-hbc, the passive hemagglutination (pha) method, has been established. the reactivity of pha cells prepared by conjugating purified recombinant hbcag-particles with fixed sheep blood cells (srbc) was highly specific to monoclonal- and polyclonal anti-hbc iggs. the sensitivity of pha method was higher than that of radioimmunoassay (ria). however, uncertainty for the positivity of anti-hbc still remained in plasma with the pha titers lower than 2(5). a ...19863738912
[an outbreak of ornithosis. the military camp in porsanger in 1982]. 20133738872
[clinical significance of plasma alpha 2-plasmin inhibitor activity in obstetrics]. 20133734048
endotoxaemia in active crohn's disease. treatment with whole gut irrigation and 5-aminosalicylic acid.endotoxins in plasma were monitored during treatment in 18 patients hospitalised for acute exacerbation of crohn's disease: systemic endotoxaemia was found on admission in all but one. the patients were randomly divided into two groups: one receiving treatment with total parenteral nutrition and steroids. to decrease the absorbable endotoxin pool, the other group was additionally treated with whole gut irrigation and 5-aminosalicylic acid was added to the lavage fluid. in most of these patients ...20133732891
[fasciculation of the median nerve in adults and in the human fetus]. 19863726653
somatotopic organization of motoneurons innervating the pronators, carpal and digital flexors and forepaw muscles in the dog: a retrograde horseradish peroxidase study.central distribution of motor neurons innervating the individual forearm and forepaw muscle through the median and ulnar nerves was studied in the dog using the retrograde horseradish peroxidase (hrp) method. all hrp-labeled cells were seen ipsilaterally in restricted parts within the dorsolateral (dl) and retrodorsolateral nucleus (rdl) of the ventral horn at levels from the cranial tip of c7 to the cranial third of t2. the results showed that motoneurons situated more cranially supply the more ...19863708348
[the empty delta sign. a useful or misleading sign in cerebral x-ray computed tomography?].one case of bifidity of the superior sagittal sinus, resulting in a false "empty delta sign", is presented. the authors emphasize the importance of the indirect signs of sinovenous thrombosis, i.e. cerebral edema and multiple or bilateral hemorrhagic infarcts, in the diagnosis of true empty delta sign.20133701671
depression and urinary free cortisol. 20133697593
laryngeal trauma vs length of intubation.the frequency histograms of six patients' laryngographs were studied pre- and post-endotracheal intubation. the changes were correlated with the length of intubation. the post-operative hoarse voice was seen as an increase in the spread of the lower frequencies, and an increase in the fundamental frequency. the latter change was thought to be a subconscious compensation for the hoarseness. the increased lower frequency spread as measured by standard deviation was directly proportional to the len ...20133694032
decisions relating to alcohol-impaired driving: an exploratory analysis.this paper focuses on an individual's decision to drive or not to drive after drinking. to evaluate this decision, a utility maximizing probabilistic choice model is specified and estimated using a sample of college students. the estimation results provide interesting insights relating to the potential effectiveness of drinking-driving countermeasures, and suggest that the most effective methods of reducing the probability of driving after drinking are those advertising and awareness campaigns t ...20133689555
lithium: long-term effects on the kidney--ii. structural changes.forty-six patients treated with lithium for an average of 8 yr participated in a follow-up study involving a kidney biopsy. the results were compared with renal biopsy specimens from an age-matched group of controls never treated with lithium. the average number of totally scelerotic glomeruli and atrophic tubuli was higher in lithium-treated patients. the histopathological changes showed significant correlations with lithium dosage schedule. both the proportions of sclerotic glomeruli, atrophic ...20133681762
efficacy of propranolol therapy after acute myocardial infarction related to coronary arterial anatomy and left ventricular function.the effect of the beta-adrenergic blocking agent propranolol on morbidity and mortality risk after acute myocardial infarction was studied relative to coronary anatomy and left ventricular (lv) ejection fraction in a subset of 406 patients participating in a randomized study of 3,837 patients in the beta blocker heart attack trial (bhat). median follow-up for this subset of patients was 28 months. the mortality rate was 2% (2 of 100) in patients with 2- and 3-vessel coronary artery disease takin ...20133673915
[clinical picture of congenital toxoplasmosis in children hospitalized at the neonatal department of the institute of pediatrics, medical academy, in lublin]. 20133670931
liposome as an adjuvant for the production of estradiol antibodies.mice immunized with liposome associated estradiol-bovine serum albumin conjugate (e2-bsa) showed a significantly higher estradiol-specific immune response than did mice injected with the free conjugate. the conjugation of estradiol with bsa is imperative, since injection of liposomes with estradiol in the lipid bilayer was found to be ineffective in inducing an immune response. entrapment of e2-bsa in neutral and positively charged liposomes was found to be a potent mode of immunostimulation, ev ...19873666803
thermodynamics of spectroelectrochemical electron transfer in a mesotetra sulphonated phenyl porphyrin iron(iii)-apomyoglobin complex. 20133666778
response of amphibian liver to external gamma irradiation. 20133659324
link protein interactions with hyaluronate and proteoglycans. characterization of two distinct domains in bovine cartilage link proteins.hyaluronic acid-binding region and trypsin-link protein were prepared from bovine nasal cartilage proteoglycan complex after trypsin digestion. binary complexes were reformed between trypsin-link protein and hyaluronic acid-binding region or hyaluronate. upon trypsin treatment of these complexes, two fragments deriving from trypsin-link protein were characterized. one of them, of 20 kda, corresponds in fact to a 140-amino acid long fragment and bears the glycosylated site of trypsin-link protein ...19873654611
[practice of oriental medicine. 8. etiology and internal and external symptoms]. 20133639179
ball thrombi in carotid artery plaque. 20123629659
phase manipulation, shift work, and jet lag: an overview.this overview stresses why it is important to avoid the effect of masking and presents a model of the mechanism of circadian synchronization based on circadian changes of nonspecific responsiveness to various zeitgeber qualities. the significance of phase responses, transitory uncoupling, frequency multiplication, and flattening of circadian functions is considered. even circadian adaptation undergoes a circaseptan reactive periodicity.20133628348
at least one thalamotelencephalic pathway in cartilaginous fishes projects to the medial pallium.injections of horseradish peroxidase into the medial pallium of the spiny dogfish, squalus acanthias, retrogradely labeled cells in the superficial portion of the dorsal pallium, the medial pallium and the septal area of the telencephalon, and in the posterior tubercle and posterior lateral thalamic nucleus of the diencephalon. except for the septal projection, all projections to the medial pallium are bilateral. labeled fibers could be traced from the injection site to caudal telencephalic leve ...20133627563
pentapeptide nuclear localization signal in adenovirus e1a.the adenovirus e1a gene products are nuclear proteins important in transcriptional control of viral functions during infection. by producing normal e1a proteins and derivatives of e1a in bacteria and microinjecting these proteins into cultured cells, we were able to examine their ability to localize to the nucleus. we showed that a short peptide sequence at the carboxyl terminus of e1a is necessary for the rapid (30-min) nuclear localization of that protein. additionally, we showed that just the ...19873614197
effect of organic vehicles on the pharmacokinetics of aminophylline administered intravenously to goats.aminophylline dissolved in water, propylene glycol, or dimethyl sulfoxide was administered intravenously to goats in a randomized cross-over experiment. model-dependent and model-independent pharmacokinetic parameters for theophylline were compared on the basis of the solvent used in the dosage form administered. no difference was found in any pharmacokinetic parameter. thus, we found no evidence for the possibility that the organic solvents studied would confound pharmacokinetic investigations ...19873612942
radiation therapy with and without chemotherapy in the treatment of localized unresectable pancreatic carcinoma. a retrospective analysis. 20113611960
the changing demographic determinants of the growth of the extreme aged. 20133609794
[acoustic indicator of membrane potential levels]. 20133609385
[effect of anaprilin on the humoral and cellular immune response].the immunosuppressive effect of anaprilin on humoral and cellular responses was established during experiments on mice. the influence of the drug on the phenomenon of hypersensitivity of delayed type begins to be revealed at the lower dose of the drug (0.5 mg/kg) as compared with the inhibitory action of the beta-adrenoblocker on antibody formation (1 mg/kg).20123609279
changes in hemodynamics and myocardial contractility during chronic sodium depletion in conscious dogs.chronic sodium depletion has been reported to decrease ejection fraction in anesthetized dogs. we tested the hypothesis that this reduction in cardiac performance is due to either hemodynamic or humoral factors. seven mongrel dogs were fed a low sodium diet (less than 2 meq na+ per day) for 5 weeks. echocardiographic and radionuclide techniques were used to monitor cardiac function. there was a gradual but significant (p less than 0.01) decrease in ejection fraction from 61 +/- 7% (sd) at baseli ...19873596785
storage conditions and stability of thyrotropin and thyroid hormones on filter paper.we evaluated the effects of temperature and humidity on thyroid hormones (t4, t3) and thyrotropin (tsh) measured in blood spots dried on filter paper. rias for t4 and t3 blood spots were optimized to measure these analytes over the neonatal and euthyroid adult reference intervals. sensitivities of the t3 and t4 assays were 0.5 and 10 nmol/l, respectively. a blood-spot immunoradiometric assay for tsh involving magnetizable particles was developed with a sensitivity of 6 milli-int. units/l. contro ...19873594835
storage conditions and stability of thyrotropin and thyroid hormones on filter paper.we evaluated the effects of temperature and humidity on thyroid hormones (t4, t3) and thyrotropin (tsh) measured in blood spots dried on filter paper. rias for t4 and t3 blood spots were optimized to measure these analytes over the neonatal and euthyroid adult reference intervals. sensitivities of the t3 and t4 assays were 0.5 and 10 nmol/l, respectively. a blood-spot immunoradiometric assay for tsh involving magnetizable particles was developed with a sensitivity of 6 milli-int. units/l. contro ...19873594835
fatal infectious mononucleosis and virus-associated hemophagocytic syndrome.a detailed clinicopathologic analysis of 52 cases of fatal infectious mononucleosis was performed. fever, rash, generalized lymphadenopathy, hepatosplenomegaly, and blood cytopenias were the characteristic findings. epstein-barr virus infection was documented in 44 of the 52 patients. a triphasic process evolved in the blood and bone marrow of 43 patients. early, the leukocyte count was elevated due to numerous atypical lymphoid cells, and the marrow was hyperplastic. later, severe pancytopenia ...19873579509
[proliferative activity of experimental brain tumors].the method of autoradiography was used to study the parameters of the cell cycle and the intensity of proliferative processes in three transplantable rat brain tumors differing in the duration of the latent period and sensitivity to chemotherapy. the tumors were found to be similar in the duration of the cell cycle and its phases, the mean values of the label index and growth fraction, and were characterized by the irregularity of the proliferative processes within the tumor; the label index was ...19873564792
voluntary hyperventilation changes recruitment order of parasternal intercostal motor units.the order of recruitment of single-motor units in parasternal intercostal muscles during inspiration was studied in normal human subjects during quiet breathing and voluntary hyperventilation. electromyograms were recorded from the second and third intercostal spaces by means of bipolar fine wire electrodes. flow at the mouth, volume, end-expired co2, and rib cage and abdominal anterior-posterior diameters were monitored. single-motor units were identified using criteria of amplitude and shape, ...19873558179
parkinsonian rigidity: the first hundred-and-one years 1817-1918. 20113550860
parkinsonian rigidity: the first hundred-and-one years 1817-1918. 20113550860
convulsions in childhood shigellosis. clinical and laboratory features in 153 children.we studied 153 children who experienced convulsions associated with shigellosis. the male-female ratio was 1.2:1.0. thirty-six children had a previous history of febrile convulsions, and 31 children had a family history of convulsive disorder. most of the children were 0.5 to 3 years of age, although 49 (32%) were older than 3 years of age and 20 (13.1%) were older than 5 years of age. all children were febrile; in 75% of the children, the temperature was over 39 degrees c. the majority of the c ...19873544808
[bacteriological study of shigellosis in the lake kivu area (central africa). developments in the last 15 years (1968-1983)].1913 shigella strains were isolated from 1968 to 1983 in lake kivu area (central africa). distribution and evolution of serotypes, biotypes and antibiotypes were studied. the majority of serotypes and biotypes were stable. however, few of these strains showed variations, among them shigella dysenteriae serotype 1, causing epidemic dysenteriae since 1981. epidemiologic survey of shigellosis in kivu seems to be rather underdeveloped (4 bacteriology laboratories for an area of 10 million inhabitant ...19863542256
clinical overview of alpha interferon. studies and future directions.the clinical development of the alpha interferons has now progressed through initial phase i and ii trials into extensive controlled clinical trial designs. alpha interferon has been a prototype of other biological agents that are now in clinical development. these agents operate through fundamentally different mechanisms of action than conventional chemotherapy and have produced a unique profile of side effects as well as response patterns. time to response is generally longer than with chemoth ...20133542185
isotope exchange at equilibrium studies with rat muscle adenylosuccinate synthetase.the kinetic mechanism of rat muscle adenylosuccinate synthetase was studied by determining the rates of isotope exchange at equilibrium. a random sequential binding mechanism was indicated for both the forward and reverse reactions. aspartate, adenylosuccinate, gdp, and pi were determined to bind in rapid equilibrium. gtp exchanges with both gdp and pi at the same rate, which is similar to the exchange rate of imp with adenylosuccinate. aspartate exchanges with adenylosuccinate at a higher rate ...19863542024
shigella from ovine faeces. 19863541356
production of shiga toxin and other cytotoxins by serogroups of shigella.we measured the cytotoxic activity of 119 strains of shigella by using a quantitative [3h]thymidine-labeled hela cell assay. we assayed 13 strains of shigella dysenteriae 1; 18 strains of s. dysenteriae types 2 and 3; and 88 strains of shigella sonnei, shigella flexneri, and shigella boydii. strains of s. dysenteriae 1 demonstrated high levels of cytotoxicity (geometric mean, 10(5.04) cd50/mg of protein; range, 10(3.95)-10(6.10). cytotoxic activities of the non-type 1 strains of s. dysenteriae a ...19863537154
comparison of dna probes and the sereny test for identification of invasive shigella and escherichia coli strains.forty-two shigella and 29 escherichia coli strains were screened for invasiveness in the sereny test and for hybridization with two recently described dna probes for the invasiveness plasmid. both probes produced identical results. all sereny-positive strains hybridized with both dna probes. three sereny-negative strains also hybridized with the probes, suggesting that there are strains containing the invasiveness plasmid that are not pathogenic in animal models.19863531233
measurement of monoclonal immunoglobulin concentrations in hybridoma cultures by competitive inhibition enzyme immunoassay. 20123523131
[conjugative r-plasmids simultaneously belonging to the 2 incompatibility groups inc i zeta and inc b].five plasmids detected in the clinical strains of shigella were studied. the plasmids had similar phenotypes of antibiotic resistance and allotted streptomycin and tetracycline resistance to the host cell. none of them allotted the bacterial cells with sensitivity to phages specific for the inc groups f, n, p and i. the molecular weights of the plasmids ranged from 47 to 50 md. the studies on the incompatibility showed that pkmr 227, pkmr 228-1, pkmr 231, pkmr 242-1 and pkmr 245 plasmids simulta ...19863521469
[use of dna-dna hybridization methods for studying the epidemiology and evolutionary similarity of drug resistance determinants].a procedure for rapid mass assay of clinical strains of microorganisms based on dna-dna hybridization was developed. epidemiology of the gentamicin resistance determinant cloned earlier from clinical strains of the same hospital was studied and its plasmid localization in representatives of various genera of enterobacteriaceae was confirmed. the studies on dot-hybridization showed that in three antibiotic-producing organisms, i.e. s. fradiae 918 producing neomycin, m. purpurea 1535 producing gen ...20123521468
the relation between production of cytotoxin and clinical features in shigellosis.the relation between in vitro production of hela cell cytotoxin by strains of shigella and clinical symptomatology was determined for 35 travelers from the united states who developed shigellosis in guadalajara, mexico. there were 25 patients with shigella sonnei, eight with shigella flexneri, one with shigella boydii, and one with shigella dysenteriae. these strains were evaluated for in vitro production of cytotoxin. the amount of cytotoxin did not correlate with the number of stools passed, t ...19863519788
[development of the classification of bacteria in the genus shigella]. 19863518304
conservative treatment of fingertip injuries.in a prospective investigation of 81 consecutive patients with fingertip injuries conservative treatment was evaluated. fingertip injuries were defined as lesions greater than or equal to 1 cm2 in the terminal phalanx without injury to the tendons or joints. all fingertip injuries were cleaned and covered by vaseline gauze and left to heal. if less than 2 mm of soft tissue covered the bone a few millimetres of bone were nibbled away to allow good cover with soft tissue. the majority of injuries ...20123508851
[rapid decisions in the situation of dichotic choice: an integrated approach which takes into account onset snd execution of the response]. 20123502909
infectious interstitial emphysema in aids. 20123497367
dexamethasone pre-treatment is antipyretic toward polyinosinic: polycytidylic acid, lipopolysaccharide and interleukin 1/endogenous pyrogen.the effect of intravenously injected dexamethasone on the febrile response of rabbits to polyinosinic: polycytidylic acid (poly i:c), lipopolysaccharide (lps) and interleukin 1/endogenous pyrogen (il1/e.p.) was studied. dexamethasone (1 mg/kg) attenuated the febrile response to poly i:c (5 micrograms/kg) but only if administered between 0.5 to 2 h before poly i:c. if it was given after poly i:c this resulted in a potentiation of the fever. antagonism of the febrile response to poly i:c by dexame ...19873495738
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