Publications

penicillin-resistant isolates of neisseria lactamica produce altered forms of penicillin-binding protein 2 that arose by interspecies horizontal gene transfer.	isolates of neisseria lactamica that have increased resistance to penicillin have emerged in recent years. resistance to penicillin was shown to be due to the production of altered forms of penicillin-binding protein 2 (pbp 2) that have reduced affinity for the antibiotic. the sequences of the pbp 2 genes (pena) from two penicillin-resistant isolates were almost identical (less than or equal to 1% sequence divergence) to that of a penicillin-susceptible isolate, except in a 175-bp region where t ...	1991	2024965
superoxol and aminopeptidase tests for identification of pathogenic neisseria species and moraxella (branhamella) catarrhalis.	the superoxol test, and prolyl aminopeptidase and gammaglutamyl aminopeptidase tests were evaluated for the detection of pathogenic neisseria spp. using 317 strains of neisseria-ceae. the superoxol test was positive for all 116 gonococci and 62 moraxella (branhamella) catarrhalis strains, but also for three strains of neisseria meningitidis, one strain of neisseria lactamica and eight saprophytic neisseriae. when using strains grown on thayer-martin medium, the positive and negative predictive v ...	1990	1974848
pharyngeal carriage of neisseria meningitidis and neisseria lactamica in households with infants within areas with high and low incidences of meningococcal disease.	in a household survey in the faroe islands, an isolated community with hyperendemic occurrence of meningococcal disease due to serogroup b 15, 1604 persons were examined for pharyngeal carriage of neisseria meningitidis and n. lactamica. two areas were chosen having experienced high (hia), and two having experienced low incidences (lia) of disease. living in hia compared with lia was associated with higher risk of n. meningitidis b 15 carriage and lower risk of n. lactamica carriage, with odds r ...	1991	1904825
acute otitis media caused by neisseria lactamica.		1991	1794375
variability in growth of neisseria polysaccharea on colistin-containing selective media for neisseria spp.	in a prospective survey of 773 healthy schoolchildren in southern alberta, canada, neisseria polysaccharea was isolated from the pharynxes of only 4 (0.5%) subjects, whereas neisseria lactamica and neisseria meningitidis were isolated from 110 (14%) and 15 (2%) children, respectively. these strains of n. polysaccharea, together with three other sporadic isolates from alberta, canada, were compared with the type strain from france and strains from spain and germany. all strains were phenotypicall ...	1991	1774246
meningococcal molecular mimicry and the search for an ideal vaccine.	the carbohydrates expressed on the surface of meningococcal strains of groups b and c mimic those commonly found on human cells and thus are not functionally antigenic in infancy. in order to develop an effective vaccine, it will be necessary to find ways of circumventing this molecular mimicry. three possible ways of achieving this are discussed. (i) the surface polysaccharides can theoretically present conformationally different epitopes, some of which might be recognized as antigenic by the h ...	1991	1725072
further antigenic similarities of neisseria gonorrhoeae lipooligosaccharides and human glycosphingolipids.	anticarbohydrate monoclonal antibodies were tested for their ability to bind to various strains of neisseria. a monoclonal antibody that binds to the ganglio-series glycosphingolipid, ganglio-n-triaosylceramide, also bound to strains of neisseria gonorrhoeae but not to other species of neisseria. an antibody specific for the globo-series glycosphingolipid, globotriaosylceramide, also bound to strains of n. gonorrhoeae, neisseria meningitidis, neisseria lactamica, and branhamella catarrhalis but ...	1992	1612771
epidemiology and molecular basis of penicillin-resistant neisseria meningitidis in spain: a 5-year history (1985-1989).	penicillin-resistant (penr) clinical isolates of neisseria meningitidis, which do not produce beta-lactamase, were first identified in spain in 1985; the frequency of their recovery, which has been increasing in the past few years, reached 20% in 1989. serogrouping, determination of serotypes and subtypes, and multilocus enzyme electrophoresis of the penr strains showed an extensive diversity. resistance is due, at least in part, to a decreased affinity of penicillin-binding protein (pbp) 2 for ...	1992	1554823
secretor status and humoral immune responses to neisseria lactamica and neisseria meningitidis.	non-secretors of abo blood group antigens are over-represented among patients with meningococcal diseases. lower levels of secretory iga reported for non-secretors have been suggested to compromise mucosal defences. total serum and salivary igg, iga and igm and levels of these isotypes specific for neisseria lactamica and five isolates of meningococci were determined by elisa for 357 pupils and staff of a secondary school in which an outbreak of meningitis occurred. there were no differences in ...	1992	1468529
lipooligosaccharides (los) of some haemophilus species mimic human glycosphingolipids, and some los are sialylated.	the lipooligosaccharides (los) of strains of haemophilus ducreyi, neisseria gonorrhoeae, neisseria meningitidis, and neisseria lactamica contain epitopes that are antigenically and structurally similar to carbohydrates present in human glycosphingolipids. los from strains of haemophilus influenzae and h. influenzae biogroup aegyptius were tested for the binding of monoclonal antibodies (mabs) that bind to human glycosphingolipids possessing gal beta 1-4glcnac (mab 3f11) and gal alpha 1-4gal beta ...	1992	1372291
letter: neisseria lactamicus pharyngitis.		1975	1173412
septicemia due to neisseria lactamica.	neisseria lactamica was isolated from the blood of a pediatric patient who had signs of septicemia and otitis media. organisms morphologically resembling neisseria, as well as gram-positive cocci, were seen on a gram stain of fluid from the middle ear. it is hypothesized that the n. lactamica septicemia was secondary to infection of the middle ear by this organism.	1976	972188
[experience with neisseria lactamica (author's transl)].	the authors have performed a detailed study of the presence of a new microbial species, neisseria lactamica which even recently had still been classified among the nontypable neisseria meningitidis strains. an examination of the spread of neisseria strains among the healthy population of this country revealed 1.6% to be carriers of neisseria lactamica as compared with 4.7% being carriers of neisseria meningitidis. from the material examined, the highest number of neisseria lactamica carriers was ...	1976	827879
neisseria lactamica meningitis.	neisseria lactamica was recovered from the blood and cerebrospinal fluid of a 7-month-old girl with acute purulent meningitis. the isolate was identified initially as n meningitidis. however, additional biochemical testing at the center for disease control showed that the organism fermented lactose and produced beta-d-galactosidase, thereby confirming its identity as n lactamica.	1976	814807
neisseria lactamica meningitis.		1978	722428
meningitis caused by neisseria lactamica.		1978	683293
the lipopolysaccharide (r type) as a common antigen of neisseria gonorrhoeae. ii. use of hen antiserum to gonococcal lipopolysaccharide in a rapid slide test for the identification of n. gonorrhoeae from primary isolates and secondary cultures.	an antiserum has been prepared in hens to r-type gonococcal lipopolysaccharide (lps) and used in a simple slide-agglutination test for the identification of neisseria gonorrhoeae. anti-lps serum agglutinated gonococcal cells representative of the four colony types of n. gonorrhoeae. absorption of the antiserum with lps removed the agglutinating activity. secondary cultures (1120) were tested without observation of the colony type and all were agglutinated. no agglutination occurred with strains ...	1978	417781
carriage of neisseria meningitidis and neisseria lactamica in infants and children.	asymptomatic carriage of neisseria meningitidis and neisseria lactamica was studied in a total of 2,969 healthy infants and children in danbury, conn., between october 1971 and june 1975. the prevalence of n. meningitidis averaged 0.71% during the first four years of life and increased to 5.4% by 14--17 years. rates of carriage of n. lactamica increased from 3.8% in three-month-old infants to a peak of 21.0% at 18 months and then declined to 1.8% by 14--17 years of age. of the children who acqui ...	1978	415097
neisseria meningitidis in the anal canal of homosexual men.	cultures were obtained from the oropharynx, urethra, and anal canal of 157 homosexual men. neisseria gonorrhoeae was identified in 30 men (19.1%), neisseria meningitidis in 32 men (20.4%), and neisseria lactamicus and branhamella catarrhalis in one man each. n. gonorrhoeae was isolated from the anal canal of three men (1.9%), and n. meninititidis was identified in the anal canal of seven men (4.5%). these findings suggest that confirmatory tests are indicated for homosexual males with rectal iso ...	1977	411836
[differential diagnosis of neisseria lactamicus from other neisserias].		1979	400540
comparison of three methods for identification of pathogenic neisseria species.	a radiometric procedure was compared with the minitek and cystine trypticase agar sugar degradation methods for identification of 113 neisseria species (58 neisseria meningitidis, 51 neisseria gonorrhoeae, 2 neisseria lactamica, 2 neisseria sicca). identification of meningococci and gonococci was confirmed by agglutination and fluorescent antibody techniques, respectively. the minitek method identified 97% of meningococci, 92% of gonococci, and 100% of other neisseria after 4 h of incubation. th ...	1979	383747
hen fluorescein-labeled gonococcal lipopolysaccharide antibody in the delayed fluorescent antibody technique for the confirmation of neisseria gonorrhoeae.	a fluorescent antibody reagent (termed anti-lps conjugate) was prepared from sera obtained from hens immunized with gonococcal r-type lipopolysaccharide. the reagent was absorbed with formalin-treated cells of neisseria meningitidis. the anti-lps conjugate gave uniform brilliant staining of neisseria gonorrhoeae with little background fluorescence, thus making interpretation and reading of fluorescence simple. the conjugate did not significantly stain cultures of n. meningitidis, neisseria lacta ...	1979	110824
inhibition of neisseria gonorrhoeae by normal human saliva.	saliva was found to be a powerful and specific inhibitor of neisseria gonorrhoeae. although 28 other species of bacteria were tested, including neisseria meningitidis, neisseria pharyngis var flava, neisseria lactamica, and neisseria catarrhalis, we failed to find any others sensitive to saliva under similar conditions. the physical properties of the inhibitory substance indicated that it might be salivary alpha-amylase. to test this hypothesis alpha-amylase was extracted from saliva and was sho ...	1979	106919