Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| a nationwide survey of hepatitis e virus infection and chronic hepatitis e in liver transplant recipients in japan. | recently, chronic hepatitis e has been increasingly reported in organ transplant recipients in european countries. in japan, the prevalence of hepatitis e virus (hev) infection after transplantation remains unclear, so we conducted a nationwide cross-sectional study to clarify the prevalence of chronic hev infection in japanese liver transplant recipients. | 2015 | 26870785 |
| design, construction and cloning of truncated orf2 and tpasp-padre-truncated orf2 gene cassette from hepatitis e virus in the pvax1 expression vector. | hepatitis e virus (hev) is the causative agent of enterically transmitted acute hepatitis and has high mortality rate of up to 30% among pregnant women. therefore, development of a novel vaccine is a desirable goal. | 2015 | 26865938 |
| distinct entry mechanisms for nonenveloped and quasi-enveloped hepatitis e viruses. | the hepatitis e virus (hev) sheds into feces as nonenveloped virions but circulates in the blood in a membrane-associated, quasi-enveloped form (ehev). since the ehev virions lack viral proteins on the surface, we investigated the entry mechanism for ehev. we found that compared to nonenveloped hev virions, ehev attachment to the cell was much less efficient, requiring a longer inoculation time to reach its maximal infectivity. a survey of cellular internalization pathways identified clathrin-me ... | 2016 | 26865708 |
| seroprevalence of hav, hbv, hcv, and hev among acute hepatitis patients at kenyatta national hospital in nairobi, kenya. | acute viral hepatitis is most frequently caused by the hepatitis a virus (hav), hepatitis b virus (hbv), hepatitis c virus (hcv), hepatitis d virus (hdv) and hepatitis e virus (hev). | 2012 | 26856042 |
| investigation of suspected viral hepatitis outbreaks in north west india. | hepatitis e (hev) infection is diagnosed on the basis of serum anti-hev igm detection. in outbreaks, early diagnostic method is important for prompt control measures. this study compared 3 diagnostic methods in 60 serum samples collected in suspected hev outbreaks. the suitability of saliva samples for antibody detection was also evaluated in 21 paired serum saliva samples. the anti-hev igm, hev-ag, and hev-rna were detected in serum samples of 52 (86.66%), 16 (26.66%), and 18 (30%) patients, re ... | 2016 | 26853491 |
| cross-genotype-specific t-cell responses in acute hepatitis e virus (hev) infection. | hepatitis e is an inflammatory liver disease caused by infection with the hepatitis e virus (hev). in tropical regions, hev is highly endemic and predominantly mediated by hev genotypes 1 and 2 with >3 million symptomatic cases per year and around 70 000 deaths. in europe and america, the zoonotic hev genotypes 3 and 4 have been reported with continues increasing new infections per year. so far, little is known about t-cell responses during acute hev genotype 3 infection. therefore, we did a com ... | 2016 | 26852892 |
| immunogenicity difference between two hepatitis e vaccines derived from genotype 1 and 4. | we investigated the immunogenicity difference between hepatitis e vaccine p239 derived from hepatitis e virus (hev) genotype 1 and vaccine p179 derived from hev genotype 4; and the presence of genotype-specific neutralizing epitopes. hev orf2 recombinant proteins (p166w01, p166mex, p166us and p166chn) derived from the four hev genotypes were used to detect anti-hev iggs in sera of mice and humans vaccinated with p179 or p239 and in sera of rhesus monkey challenged with hev genotype 1 or 4 strain ... | 2016 | 26850829 |
| review: approaches to the viral extraction, detection, and identification of hepatitis viruses, hav and hev, in foods. | although the incidence rate of hepatitis a virus (hav) infection has been on the decline in developed countries, in part due to immunization availability, high profile outbreaks continue to be reported. hepatitis e virus has been recognized as an emerging pathogen in industrialized countries. while associated with waterborne illnesses, particularly in undeveloped countries, several animal species have been identified as reservoirs for the virus. consequently, the potential of zoonotic transmissi ... | 2017 | 26846628 |
| [prevention of hepatitis e virus]. | 2015 | 26846011 | |
| [virological characteristics of hepatitis e virus]. | 2015 | 26846008 | |
| acute hepatitis e virus infection in human immunodeficiency virus-positive men and women in nepal: not quite a rare entity. | 2016 | 26845252 | |
| hepatitis e virus superinfection and clinical progression in hepatitis b patients. | hepatitis e virus (hev) infection may cause acute hepatitis and lead to hepatic failure in developing and developed countries. we studied hev seroprevalences in patients with hepatitis b virus (hbv) infection to understand the consequences of hev superinfection in a vietnamese population. this cross-sectional study was conducted from 2012 to 2013 and included 1318 vietnamese patients with hbv-related liver diseases and 340 healthy controls. the case group included patients with acute (n = 26) an ... | 2015 | 26844288 |
| virology, serology, and demography of hepatitis e viremic blood donors in south east england. | hepatitis e virus (hev) genotype 3 (g3) in england comprises two principal phylogenetic groups (group 1 and group 2) and can be transmitted by transfusion. unselected screening identified 79 viremic donors; 76 participated in a follow-up study. | 2016 | 26841005 |
| hepatitis e virus as a cause of acute hepatitis in the netherlands. | recent studies indicate that 27% of dutch blood donors have evidence of past infection with hev. however, the low number of diagnosed hev infections indicates either an asymptomatic course or under diagnosis. | 2016 | 26840767 |
| hepatitis e in transplantation. | hepatitis e virus (hev) has a worldwide distribution and is known to cause acute and fulminant hepatitis. however, over the last few years, it has been shown to also cause chronic hepatitis and cirrhosis in immunosuppressed patients, especially solid-organ-transplant patients. in immunocompetent and immunosuppressed patients, hev is also associated with extra-hepatic manifestations, such as neurological symptoms and kidney injury. unfortunately, a diagnostic assay for hev infection is still not ... | 2016 | 26838163 |
| hepatitis e virus seroprevalence among blood donors in bushehr, south of iran. | although so far several studies have determined the hepatitis e virus (hev) prevalence in some parts of iran, no data exists regarding the hev seroprevalence in bushehr province as the southernmost point in iran yet. | 2015 | 26834784 |
| production and characterization of a brazilian candidate antigen for hepatitis e virus genotype 3 diagnosis. | hepatitis e, caused by hepatitis e virus (hev), is a viral infectious pathology of great importance in the public health. hepatitis e outbreaks were registered in developing countries with poor or no sanitation, where drinking water was contaminated with fecal material, but also in many industrialized countries probably due to consumption of hev-positive swine meat. in this study, we present the development and characterization of a recombinant antigen from orf2 hev genotype 3. viral rna was ext ... | 2016 | 26832642 |
| concomitant outbreaks of yellow fever and hepatitis e virus in darfur states, sudan, 2012. | yellow fever (yf) is a vector-borne disease transmitted to humans by infected aedes mosquitoes, while hepatitis e virus (hev) is a waterborne disease that is transmitted through the fecal-oral route. both diseases have very close clinical presentation, namely fever, jaundice, malaise, and dark urine; they differ in severity and outcome. | 2016 | 26829534 |
| hepatitis e virus does not contribute to hepatic decompensation among patients with advanced chronic hepatitis c. | hepatitis e (hev) can cause acute-on-chronic liver failure in persons with pre-existing liver disease. we investigated whether hev infection contributes to hepatic decompensation in patients with previously stable, advanced chronic hepatitis c. | 2016 | 26820399 |
| hepatitis e virus infection among blood donors in the south caribbean: is screening warranted? | 2016 | 26819367 | |
| no evidence of genotype-3 hepatitis e virus-induced myocarditis. | 2016 | 26815640 | |
| hepatitis e: an underdiagnosed, emerging infection in nonendemic regions. | although hepatitis e virus (hev) is the primary cause of enterically transmitted acute hepatitis and jaundice in developing countries, locally acquired hev infections are increasing in nonendemic countries. as such, hev is emerging as an underdiagnosed cause of infection. this report describes three clinically variable cases of hev infection with unusual clinical presentations. these cases highlight the fact that hev should be considered in the differential diagnosis of patients with unexplained ... | 2015 | 26807386 |
| hepatitis e virus infection in the liver transplant recipients: clinical presentation and management. | hepatitis e virus (hev) is an emerging pathogen and an increasingly recognized cause of graft hepatitis, especially in the post-orthotopic liver transplantation immunocompromised population. the exact incidence and prevalence of hev infection in this population remains unclear but is certainly greater than historical estimates. identifying acute hev infection in this population is imperative for choosing the right course of management as it is very difficult to distinguish histologically from ac ... | 2016 | 26807207 |
| human liver chimeric mice as a new model of chronic hepatitis e virus infection and preclinical drug evaluation. | hepatitis e virus (hev) is a major cause of acute hepatitis as well as chronic infection in immunocompromised individuals; however, in vivo infection models are limited. the aim of this study was to establish a small animal model to improve our understanding of hev replication mechanisms and permit the development of effective therapeutics. | 2016 | 26805671 |
| two uncommon causes of guillain-barré syndrome: hepatitis e and japanese encephalitis. | we are presenting two cases of guillain-barré syndrome where it is preceded by hepatitis e virus (hev) and japanese encephalitis virus (jev) infection, respectively. our first case is a forty-three-year-old nondiabetic, nonhypertensive female who was initially diagnosed with acute hev induced viral hepatitis and subsequently developed acute onset ascending quadriparesis with lower motor neuron type of bilateral facial nerve palsies and respiratory failure. second patient was a 14-year-old young ... | 2015 | 26798531 |
| ferret hepatitis e virus infection induces acute hepatitis and persistent infection in ferrets. | ferret hepatitis e virus (hev), a novel hepatitis e virus, has been identified in ferrets. however, the pathogenicity of ferret hev remains unclear. in the present study, we compared the hev rna-positivity rates and alanine aminotransferase (alt) levels of 63 ferrets between before and after import from the us to japan. we found that the ferret hev-rna positivity rates were increased from 12.7% (8/63) to 60.3% (38/63), and alt elevation was observed in 65.8% (25/38) of the ferret hev rna-positiv ... | 2016 | 26790932 |
| antiviral activities of different interferon types and subtypes against hepatitis e virus replication. | hepatitis e virus (hev) is the causative agent of hepatitis e in humans and a member of the genusorthohepevirusin the familyhepeviridae hev infections are the common cause of acute hepatitis but can also take chronic courses. ribavirin is the treatment of choice for most patients, and type i interferon (ifn) has been evaluated in a few infected transplant patientsin vivo in this study, the antiviral effects of different exogenously administered interferons were investigated by using state-of-the ... | 2016 | 26787701 |
| chemically activatable viral capsid functionalized for cancer targeting. | to design a theranostic capsule using the virus-like nanoparticle of the hepatitis e virus modified to display breast cancer cell targeting functional group (lxy30). | 2016 | 26786134 |
| full coding hepatitis e virus genotype 3 genome amplification method. | hepatitis e virus (hev) genotype 3 produces zoonotic infection associated with the consumption of infected animals. hev infections can become chronic in immunocompromised (ic) patients. the viral genome has three well defined open reading frames (orf1, orf2 and orf3) within which various domains and functions have been described. this paper (i) describes a new method of complete sequencing of the hev coding region through overlapping pcr systems, (ii) establishes a consensus sequence and polymor ... | 2016 | 26784284 |
| [new viral risks in blood transfusion by 2016]. | viral safety remains a major concern in transfusion of blood products. over years, the control measures applied to blood products were made more and more sophisticated; however, the number of infectious agents, and notably of viruses, that can be transmitted by transfusion is increasing continuously. the aim of this review paper is to actualize that published in the same journal by the same authors in 2011 with more details on some of actual vs virtual viral threats that were identified recently ... | 2016 | 26781857 |
| a trivalent vaccine candidate against hepatitis e virus, norovirus, and astrovirus. | hepatitis e virus (hev), norovirus (nov), and astrovirus (astv) are enterically-transmitted viral pathogens causing epidemic or endemic hepatitis (hev) and gastroenteritis (nov and astv) respectively in humans, leading to significant morbidity and mortality worldwide. while a recombinant subunit vaccine against hevs is available in china, there is no commercial vaccine or antiviral against nov or astv. we report here our development of a trivalent vaccine against the three viral pathogens throug ... | 2016 | 26778421 |
| seroepidemiology of hepatitis e in selected population groups in croatia: a prospective pilot study. | hepatitis e has become an emerging infection in many european countries. we analysed the prevalence of hepatitis e virus (hev) infection in selected population groups in croatia. overall hev igg seropositivity was 5.6%, while 1.9% participants showed igm antibodies suggestive of recent infection. no igm-positive sample was positive for hev rna. hev igg antibodies were most prevalent in alcohol abusers (8.9%) and war veterans (8.6%), compared with 6.1% among injecting drug users and 2.7% in healt ... | 2016 | 26776465 |
| prophylaxis against hepatitis e: at risk populations and human vaccines. | hepatitis e is an emerging global disease caused by hepatitis e virus (hev) infection. while in developing countries the infection was primarily due to poor sanitary conditions through intake of contaminated water or undercooked meats of infected animals, increasing cases of chronic hepatitis e resulting in rapidly progressive liver cirrhosis and end-stage liver disease have been reported in organ transplant patients or in immune compromised patients in developed countries. fortunately, hepatiti ... | 2016 | 26775537 |
| a public health initiative on hepatitis e virus epidemiology, safety and control in portugal--study protocol. | the discovery of autochthonous hepatitis e in industrialized countries has changed the understanding of hepatitis e virus (hev) infection in these regions, now known to be mainly due to zoonotic transmission of genotype 3. the foodborne route of transmission via consumption of contaminated meat from hev infected pigs is well documented as well as the direct occupational exposure to animal reservoirs. accumulating evidence also points to an emerging potential threat to blood safety after the iden ... | 2016 | 26774897 |
| orf3 of hepatitis e virus inhibits the expression of proinflammatory cytokines and chemotactic factors in lps-stimulated human pma-thp1 cells by inhibiting nf-κb pathway. | hepatitis e virus (hev) is one of the primary causative agents of acute hepatitis. it is noteworthy that hev can develop chronic infection and even lead to liver cirrhosis; however, the mechanism has not been revealed. in this study, the elisa assay was used to detect protein levels, and we found that hev open reading frame 3 (orf3) protein inhibited the expression of proinflammatory cytokines (tumor necrosis factor-alpha [tnf-α], interleukin [il]-1β, il-6, il-8, il-12p40, and il-18) and chemota ... | 2016 | 26771290 |
| production of infectious ferret hepatitis e virus in a human hepatocarcinoma cell line plc/prf/5. | a strain of ferret hepatitis e virus (hev), sf4370, isolated from an imported ferret was used to inoculate a human hepatocarcinoma cell line, plc/prf/5. the virus genome and capsid protein were detected in the cell culture supernatant. immunofluorescence microscopy indicated that the capsid protein was located in the cytoplasm. the virus particles were purified from the culture supernatant by sucrose gradient ultracentrifugation. the capsid protein with molecular mass of ∼72 kda was detected in ... | 2016 | 26763355 |
| prevalence of anti-hepatitis e virus antibodies and first detection of hepatitis e virus in wild boar in slovenia. | hepatitis e is an emerging zoonotic disease caused by hepatitis e virus (hev). in this study, we investigated hev presence in a wild boar (sus scrofa) population of slovenia. a total of 288 wild boar serum samples were collected throughout the country, and hev infection was investigated by serology, using enzyme-linked immunosorbent assay (elisa) and by hev rna detection using a real-time pcr assay. antibodies against hev were detected in 30.2% (87/288) of animals tested, whereas hev rna was det ... | 2016 | 26757050 |
| hepatitis e virus outbreak in postearthquake nepal: is a vaccine really needed? | 2016 | 26756604 | |
| hepatitis e virus seroprevalence in free-ranging deer in canada. | hepatitis e virus infection (hev) is an important public health concern not only in traditional endemic areas, but also in some industrialized countries where both domesticated and wild animals have been recognized as potential zoonotic reservoirs implicated in hev transmission. while the prevalence of infection in the deer population in europe and asia has been thoroughly investigated, it remains largely undetermined in north america. we assessed the presence of hev in three different species o ... | 2016 | 26752436 |
| simulation of viral hepatitis e in marmosets. | we developed a model of hepatitis e virus infection in common marmosets (callithrix jacchus) and determined optimal route of infection, duration, clinical and virological characteristics of infection in laboratory animals. using this model, we demonstrated that replication of hepatitis e virus primarily occurs in the liver, while virus replication presumed to take place in the intestine was not confirmed in this experiment. | 2016 | 26750931 |
| proposed reference sequences for hepatitis e virus subtypes. | the nomenclature of hepatitis e virus (hev) subtypes is inconsistent and makes comparison of different studies problematic. we have provided a table of proposed complete genome reference sequences for each subtype. the criteria for subtype assignment vary between different genotypes and methodologies, and so a conservative pragmatic approach has been favoured. updates to this table will be posted on the international committee on taxonomy of viruses website (http://talk.ictvonline.org/r.ashx?c). ... | 2016 | 26743685 |
| seroprevalence of hepatitis e virus infection among dogs in several developed cities in the guangdong province of china. | hepatitis e virus (hev), as a zoonotic disease virus, was seldom studied in dogs especially in stray dogs. as previously reported, dog might be an accidental host of hev for human beings and some risk factors might play an important role in hev transmission. thus, we designed this study to evaluate the seroprevalence of hev infection among dogs in several cities in guangdong province of china. this surveillance may help us understand risk factors including location, gender, live type, and diet h ... | 2016 | 26743155 |
| development and evaluation of a rt-lamp assay for rapid detection of hepatitis e virus from shellfish. | hepatitis e virus (hev) has becoming a well known zoonotic enteric pathogen and circulated widely inter human-animal-water-food. generally, detection of the virus has relied on conventional reverse transcription-pcr (rt-pcr) and taqman/sybr quantitative real-time rt-pcr (rt-qpcr), but these tools are usually disadvantages in time-consuming and expensive instruments required. in the present study, we report here on the development of a one-step single-tube reverse transcription-loop-mediated isot ... | 2016 | 26741532 |
| hepatic failure after pig heart transplantation into a baboon: no involvement of porcine hepatitis e virus. | after transplantation of pig hearts into baboons, a particularly high increase of liver parameters was observed in 1 animal. to evaluate whether porcine hepatitis e virus (hev) was involved in the pathological changes, the donor pig and the recipient baboon were screened for the presence of hev. | 2016 | 26739324 |
| when should ribavirin be started to treat hepatitis e virus infection in transplant patients? | 2016 | 26729540 | |
| hepatitis e, the neglected one. | hepatitis e virus (hev) infection is a worldwide disease. it is the first cause of acute viral hepatitis in the world with an estimated 20 million cases every year and 56 000 deaths. in developing countries, hepatitis e is a waterborne infection. in these countries, hev genotypes 1 and 2 cause large outbreaks and affect young subjects with a significant mortality rate in pregnant women and patients with cirrhosis. in the developed countries, hev genotypes 3 and 4 are responsible for autochthonou ... | 2016 | 26725910 |
| antigen detection and apoptosis in mongolian gerbil's kidney experimentally intraperitoneally infected by swine hepatitis e virus. | we examined the effect of hepatitis e virus (hev) on the renal tissue pathogenesis, morphological damages and related molecular mechanisms following swine hev suspension intraperitoneally inoculation in mongolian gerbils. the microscopic and ultramicroscopic analyses of kidney tissue structure were carried out at different points after inoculation of hev. the immunohistochemistry, real-time pcr and western blot were performed to explore the molecular mechanisms associated with hev presence in th ... | 2016 | 26724751 |
| hepatitis e virus and neurological injury. | hepatitis e is hyperendemic in many developing countries in asia and africa, and is caused by hepatitis e virus (hev) genotypes 1 and 2, which are spread via the faecal-oral route by contaminated water. recent data show that hev infection is also endemic in developed countries. in such geographical settings, hepatitis e is caused by hev genotypes 3 and 4, and is mainly a porcine zoonosis. in a minority of cases, hev causes acute and chronic hepatitis, but infection is commonly asymptomatic or un ... | 2016 | 26711839 |
| mutation in the hepatitis e virus polymerase and outcome of ribavirin therapy. | hepatitis e virus (hev) can lead to chronic infection in solid-organ transplant patients. ribavirin is efficient for treatment of chronically infected patients. recently, the1634r mutation in the hev polymerase has been associated with treatment failure. however, it is unclear if this mutation can be used as a prognostic marker of treatment outcome. we studied the prevalence of the 1634r mutation in the hev polymerase of patients starting ribavirin therapy, the influence of the 1634r variants on ... | 2015 | 26711757 |
| coastal clustering of hev; cornwall, uk. | autochthonous hepatitis e virus (hev) infection is a porcine zoonosis and increasingly recognized in developed countries. in most cases the route of infection is uncertain. a previous study showed that hev was associated geographically with pig farms and coastal areas. | 2016 | 26709884 |
| frequency of hepatitis e and hepatitis a virus in water sample collected from faisalabad, pakistan. | hepatitis e and hepatitis a virus both are highly prevalent in pakistan mainly present as a sporadic disease. the aim of the current study is to isolate and characterized the specific genotype of hepatitis e virus from water bodies of faisalabad, pakistan. drinking and sewage samples were qualitatively analyzed by using rt-pcr. hev genotype 1 strain was recovered from sewage water of faisalabad. prevalence of hev and hav in sewage water propose the possibility of gradual decline in the protectio ... | 2015 | 26706972 |
| [molecular investigation on the presence of hepatitis e virus in wild game in okazaki city, japan between april 2010 and november 2014]. | cases of hepatitis e have been caused by infection with hepatitis e virus (hev) due to consumption of raw or undercooked game meats and liver of wild boars or deer in various countries. we investigated hev prevalence in wild boar and deer in okazaki city and its outskirts, aichi, japan, using liver samples (439 boar; 185 deer) collected between april 2010 and november 2014. hev rna was detected in 49 (11.2%)of 439 and 0 of 185 samples of wild boar and deer, respectively. the positive rate (13.0% ... | 2015 | 26699273 |
| hepatitis e virus orf1 encoded non structural protein-host protein interaction network. | hepatitis e virus orf1 encoded non-structural polyprotein (nsp) consist of multiple domains, namely: methyltransferase, y-domain, protease, x-domain, helicase and rna dependent rna polymerase. we have attempted to identify human liver cell proteins that are interacting with hev orf1 encoded functional domains by using y2h screening. a total of 155 protein-protein interactions between hev-orf1 and human proteins were identified. comparative analysis of the hev-orf1-human interaction network with ... | 2016 | 26689634 |
| hepatitis e virus genotype 3 infection in a tertiary referral center in the netherlands: clinical relevance and impact on patient morbidity. | hepatitis e virus (hev) genotype 3 infections can have important clinical consequences. | 2016 | 26687439 |
| hepatitis e virus-induced cryoglobulinemic glomerulonephritis in a nonimmunocompromised person. | hepatitis e virus (hev)-related kidney disease and symptomatic cryoglobulinemia have been observed in solid-organ transplant recipients. however, hev rna in the cryoprecipitate has not yet been assessed. we report what to our knowledge is the first documented case of autochthonous hev-induced cryoglobulinemic crescentic and membranoproliferative glomerulonephritis in an immunocompetent man with no notable medical history. he presented with edema, hypertension, increased serum creatinine level, a ... | 2016 | 26682764 |
| diagnostic performance of five assays for anti-hepatitis e virus igg and igm in a large cohort study. | determination of anti-hepatitis e virus (anti-hev) antibodies is still enigmatic. there is no gold standard, and results obtained with different assays often diverge. herein, five assays were compared for detection of anti-hev igm and igg. serum samples from 500 swedish blood donors and 316 patients, of whom 136 had suspected hev infection, were analyzed. concordant results for igm and igg with all assays were obtained only for 71% and 70% of patients with suspected hepatitis e, respectively. th ... | 2016 | 26659210 |
| hepatitis e virus seroprevalence in pregnant women in jiangsu, china, and postpartum evolution during six years. | china is an endemic area for hepatitis e virus (hev). the previous surveys of anti-hev seroprevalence are cross-sectional. this study aimed to investigate the prevalence of infection among pregnant women and their children in jiangsu, china, and to observe postpartum anti-hev evolution. | 2015 | 26653888 |
| [investigation of the hepatitis e virus seroprevalence in cases admitted to hacettepe university medical faculty hospital]. | hepatitis e virus (hev), classified in hepeviridae family, hepevirus genus, is a non-enveloped virus with icosahedral capsid containing single-stranded positive sense rna genome. hev infections may be asymptomatic especially in children, however it may present as fulminant hepatitis in pregnant women, as well as chronic hepatitis in immunocompromised patients. there are four well-known genotypes of hev that infect humans and many mammalian species. genotype 1 and 2 are frequently responsible for ... | 2015 | 26649413 |
| acute and chronic hepatitis e virus infection in human immunodeficiency virus-infected u.s. women. | exposure to hepatitis e virus (hev) is common in the united states, but there are few data on prevalence of hev/human immunodeficiency virus (hiv) coinfection in u.s. | 2016 | 26646162 |
| a novel multiplex isothermal amplification method for rapid detection and identification of viruses. | a rapid multiplex isothermal amplification assay has been developed for detection and identification of multiple blood-borne viruses that infect millions of people world-wide. these infections may lead to chronic diseases or death if not diagnosed and treated in a timely manner. sets of virus-specific oligonucleotides and oligofluorophores were designed and used in a reverse-transcription loop-mediated multiplexed isothermal amplification reaction for detection and gel electrophoretic identifica ... | 2015 | 26643761 |
| hepatitis e virus serum antibodies and rna prevalence in patients evaluated for heart and kidney transplantation. | acute hepatitis e virus (hev) infection in solid organ transplant recipients is rare, but can cause severe hepatic and extrahepatic complications. we sought to identify the pretransplant prevalence of hev infection in heart and kidney candidates and any associated risk factors for infection. | 2015 | 26626638 |
| stem cell-derived hepatocytes: a novel model for hepatitis e virus replication. | yearly, approximately 20million people become infected with the hepatitis e virus (hev) resulting in over 3million cases of acute hepatitis. although hev-mediated hepatitis is usually self-limiting, severe cases of fulminant hepatitis as well as chronic infections have been reported, resulting annually in an estimated 60,000 deaths. we studied whether pluripotent stem cell (psc)-derived hepatocytes, mesodermal and/or neuroprogenitor cells support hev replication. | 2016 | 26626494 |
| hepatitis e virus seroprevalence rate in hiv-infected patients in germany: a comparison of two commercial assays. | cases of chronic hepatitis e virus (hev) infection have been described in hiv-infected patients. there are several commercial anti-hev assays, but anti-hev seroprevalence rates differ largely depending on the assay used. the aim of this study was to (1) compare two commercial anti-hev assays in a german cohort of hiv-positive individuals, and (2) determine whether hev takes chronic courses in controlled hiv infection. | 2015 | 26625157 |
| hepatitis e virus infection and acute-on-chronic liver failure in west africa: a case-control study from the gambia. | in sub-saharan africa, it is unknown whether hepatitis e virus (hev) infection is a common precipitating event of acute-on-chronic liver failure (aclf). | 2016 | 26623967 |
| hepatitis e virus seroprevalence in hiv positive individuals in shiraz, southern iran. | hepatitis e virus (hev) is the most common cause of acute viral hepatitis in the world. it is usually a self-limited disease but may leads to the deaths of about 20% of pregnant women in developing countries. this study was conducted to determine the prevalence of hev infection among hiv individuals . | 2015 | 26622971 |
| the association of cytokines and micronutrients with hepatitis e virus infection during pregnancy and the postpartum period in rural bangladesh. | hepatitis e virus (hev) infection is severe during pregnancy, with a pregnant case fatality rate around 30%. in bangladesh, plasma samples from 1,100 women during the first trimester (tm) and third tm of pregnancy and 3 months postpartum (pp) were tested for anti-hev igg. during this time, 40 women developed antibody responses to hev. these seroconverters are classified as the cases (incidence = 46 infections per 1,000 person-years). all except one seroconversion occurred between the third tm an ... | 2016 | 26621563 |
| [seroprevalence of hepatitis e virus in patients with hepatitis c and / or infected with hiv]. | hepatitis e virus (hev) can cause chronic infection and cirrhosis. the seroprevalence data of anti-hev igg in the patients infected with hiv or with chronic liver disease are scarce. | 2015 | 26621176 |
| disparity of basal and therapeutically activated interferon signalling in constraining hepatitis e virus infection. | hepatitis e virus (hev) represents one of the foremost causes of acute hepatitis globally. although there is no proven medication for hepatitis e, pegylated interferon-α (ifn-α) has been used as off-label drug for treating hev. however, the efficacy and molecular mechanisms of how ifn signalling interacts with hev remain undefined. as ifn-α has been approved for treating chronic hepatitis c (hcv) for decades and the role of interferon signalling has been well studied in hcv infection, this study ... | 2016 | 26620360 |
| case report associated with aspergillosis and hepatitis e virus coinfection in himalayan griffons. | this study involved a death which occurred in four himalayan griffons housed in beijing zoo, china. based on pathogen identification and the pathological changes observed, we did characterize the fungi and hepatitis e virus (hev) in four dead himalayan griffons. pathological changes were severe. membranous-like material was observed on the surface of the internal organs. spleen was necrotic. focal lymphocyte infiltration in the liver and many sunflower-like fungi nodules were evident in the tiss ... | 2015 | 26605326 |
| recent trend of hepatitis e virus infection in chiba area, japan: 3 of 5 cases with rheumatoid arthritis. | hepatitis e virus (hev) infection is an emerging health concern in developing and developed countries, such as japan. five cases have recently been diagnosed as hepatitis e. of interest, 3 of them had rheumatoid arthritis (ra), although a previous study demonstrated a lack of association between hev and ra. one of the other patients developed autoimmune hepatitis and was successfully treated with corticosteroids approximately 150 days after the diagnosis of hepatitis e. in ra patients with liver ... | 2017 | 26600768 |
| viral hepatitis in pregnancy--a study of its effect on maternal and foetal outcome. | the outcome of hepatitis during pregnancy has been observed to be widely different by various authors, ranging from the benign to fatal. a poor outcome has increasingly been observed in pregnant women suffering from hepatitis in central india. hence, this study was undertaken to study the incidence, causative organisms and chief prognostic factors affecting the outcome of viral hepatitis in pregnant women. | 2015 | 26591124 |
| hepatitis e virus infections in children age 0-15, uganda outbreak, 2007. | the epidemiology of hepatitis e virus (hev) infections among children is not well understood, with some studies reporting that hepatitis e infections do not affect children. | 2015 | 26590690 |
| [chronic hepatitis caused by hepatitis e virus and treated with ribavirin]. | 2016 | 26589539 | |
| role of asparagine at position 562 in dimerization and immunogenicity of the hepatitis e virus capsid protein. | the hepatitis e virus (hev) capsid protein, porf2, contains 2 potential n-glycosylation sites, n137 and n310, located in the s domain, and one site, n562, in the p domain. the last domain located at positions 454-606 aa forms a protruding spike from the shell, with n562 being located in the apical center of the spike, which is also a cell-attachment region and neutralizing antigenic site. here, we expressed in pichia pastoris a recombinant polypeptide p179 comprising the region of 439-617 aa of ... | 2016 | 26584510 |
| hepatitis e virus infection: epidemiology and treatment implications. | hepatitis e virus (hev) infection is now established as an emerging enteric viral hepatitis. standard treatments in acute and chronic hepatitis e remain to be established. this study undertakes a review of the epidemiology, treatment implication and vaccine prevention from published literature. hev infection is a worldwide public health problem and can cause acute and chronic hepatitis e. hev genotypes 1 and 2 are primarily found in developing countries due to waterborne transmission, while the ... | 2015 | 26568916 |
| subclinical avian hepatitis e virus infection in layer flocks in the united states. | the objective of this study was to determine patterns of avian hev infection in naturally infected chicken farms. a total of 310 serum samples and 62 pooled fecal samples were collected from 62 chicken flocks on seven commercial in-line egg farms in the midwestern united states and tested for avian hev circulation. serum samples were tested for the presence of anti-avian hev igy antibodies by a fluorescent microbead immunoassay (fmia) which was developed for this study. the fmia was validated us ... | 2015 | 26564555 |
| incidence and duration of hepatitis e virus infection in dutch blood donors. | the incidence of hepatitis e virus (hev) infection in the netherlands is high. blood donors are not routinely screened for hev infection, but since january 2013, donations used for the production of solvent/detergent (s/d)-treated plasma have been screened for hev rna. | 2016 | 26559806 |
| hepatitis e virus. | 2015 | 26557817 | |
| serological and molecular investigation of swine hepatitis e virus in pigs raised in southern italy. | hepatitis e virus (hev) infection is a common acute hepatitis transmitted by the fecal-oral route. in developed countries, the virus has a zoonotic potential, and domestic pigs and wild boars are considered main reservoirs. to assess the prevalence of hev-positive animals in the calabria region (southern italy) on a serological and molecular level, a total of 216 autochthonous healthy pigs (apulo-calabrese breed) were sampled. both sera and feces were collected. pigs were grouped based on age: 1 ... | 2015 | 26555536 |
| chronic infection with camelid hepatitis e virus in a liver transplant recipient who regularly consumes camel meat and milk. | there have been increasing reports of food-borne zoonotic transmission of hepatitis e virus (hev) genotype 3, which causes chronic infections in immunosuppressed patients. we performed phylogenetic analyses of the hev sequence (partial and full-length) from 1 patient from the middle east who underwent liver transplantation, and compared it with other orthohepevirus a sequences. we found the patient to be infected by camelid hev. this patient regularly consumed camel meat and milk, therefore came ... | 2016 | 26551551 |
| serologic and molecular survey of hepatitis e virus in german deer populations. | hepatitis e virus (hev) is a human pathogen that is primarily transmitted by the fecal-oral route and causes a usually self-limiting acute viral hepatitis. the virus is endemic in developing countries of africa, asia, and latin america and is responsible for sporadic cases in industrialized countries. in western europe, an increasing number of autochthonous cases have been associated with zoonotic transmissions of hev from domestic and wild animals. in germany, animal reservoirs for hev have bee ... | 2016 | 26528571 |
| requirement of the eukaryotic translation initiation factor 4f complex in hepatitis e virus replication. | hepatitis e virus (hev) infection, one of the foremost causes of acute hepatitis, is becoming a health problem of increasing magnitude. as other viruses, hev exploits elements from host cell biochemistry, but we understand little as to which components of the human hepatocellular machinery are perverted for hev multiplication. it is, however, known that the eukaryotic translation initiation factors 4f (eif4f) complex, the key regulator of the mrna-ribosome recruitment phase of translation initia ... | 2015 | 26526587 |
| [clinical feature analysis of 334 chronic hepatitis b patients coinfected with hepatitis e virus]. | 2015 | 26524366 | |
| epidemiology of hepatitis e virus infection during pregnancy in benin. | hepatitis e virus (hev) is the cause of enterically transmitted non-a, non-c hepatitis (an infection that is particularly severe during pregnancy) in tropical and subtropical countries. as there are no published data concerning the prevalence of hev antibodies in benin, their presence was investigated in pregnant women undergoing routine hiv screening in a rural area in northern benin and in pregnant women with acute non-a, non-c hepatitis. | 2016 | 26523476 |
| acute hepatitis e virus in pregnant women in israel and in other industrialized countries. | acute hepatitis e virus (hev) is the most common etiology of viral hepatitis in adults in developing countries. hev is rare in industrialized countries but its incidence is rising both in returning travelers and through autochthonous infection. in developing countries hev is associated with a high rate of fulminant hepatitis and mortality during pregnancy and contributes to poor obstetric and fetal outcomes. there are no reliable data on the outcome of hev during pregnancy in industrialized coun ... | 2015 | 26521225 |
| acute on chronic liver failure because of acute hepatic insults: etiologies, course, extrahepatic organ failure and predictors of mortality. | acute on chronic liver failure (aclf) because of precipitating factors (variceal bleed/infections) identifies cirrhotics at risk for high short-term mortality. information on aclf because of acute hepatic insults is lacking. the aim of the study was to evaluate acute hepatic insults in aclf and their effect on the course and outcome. | 2016 | 26519215 |
| belgian wildlife as potential zoonotic reservoir of hepatitis e virus. | hepatitis e is an acute human liver disease in healthy individuals but may become chronic in immunocompromised patients. it is caused by the hepatitis e virus (hev) and can have a zoonotic origin, particularly in high-income countries. in this study, 383 sera from wild boars were selected for serology; for virological analyses, 69 sera and 61 livers from young wild boars were used. a total of 189 and 235 sera of, respectively, red deer and roe deer were collected for serological analysis. for vi ... | 2015 | 26518619 |
| detection of hepatitis e virus in archived rabbit serum samples, germany 1989. | we detected hepatitis e virus in serum samples of wild rabbits that were hunted in 1989 around the city of greifswald, germany. the recovery of one partial sequence and subsequent phylogenetic analysis indicates a close relationship to rabbit hev sequences from france and suggests a long-established circulation of rabbit hev in europe. | 2016 | 26518295 |
| epidemiology of hepatitis e virus in european countries. | over the last decade the seroprevalence of immunoglobulin (igg) anti hepatitis e virus (hev) has been increasing in european countries and shows significant variability among different geographical areas. in this review, we describe the serological data concerning the general population and risk groups in different european countries. anti-hev antibody prevalence ranged from 1.3% (blood donors in italy) to 52% (blood donors in france). various studies performed on risk groups in denmark, moldova ... | 2015 | 26516843 |
| hepatitis e-induced severe myositis. | hepatitis e virus (hev) is endemic in asian and african countries but is rarely reported in western countries. although there are some prominent neurological manifestations, hev is rarely recognized by neurologists. | 2016 | 26514272 |
| role of tlr gene expression and cytokine profiling in the immunopathogenesis of viral hepatitis e. | the clinical manifestations of hepatitis e virus (hev) range from self-limiting acute viral hepatitis (avh) to acute liver failure (alf). the varied clinical course is thought to be immune-mediated. toll-like receptors (tlrs) play a central role in sensing and initiating innate antiviral-response and downstream signaling of tlrs modulates cytokine production, thereby playing an important role in determining the disease course. | 2015 | 26512422 |
| acute hepatitis e virus infection with coincident reactivation of epstein-barr virus infection in an immunosuppressed patient with rheumatoid arthritis: a case report. | hepatitis e virus (hev) is the most recently discovered of the hepatotropic viruses, and is considered an emerging pathogen in developed countries with the possibility of fulminant hepatitis in immunocompromised patients. especially in the latter elevated transaminases should be taken as a clue to consider hev infection, as it can be treated by discontinuation of immunosuppression and/or ribavirin therapy. to our best knowledge, this is a unique case of autochthonous hev infection with coinciden ... | 2015 | 26511098 |
| clinical analysis of patients suffering from chronic hepatitis b superinfected with other hepadnaviruses. | to compare the clinical manifestations, laboratory examinations, and prognoses of patients with chronic hepatitis b (chb) who were superinfected with hepatitis a virus (hav), hepatitis c virus (hcv), hepatitis d virus (hdv), or hepatitis e virus (hev). two hundred and eleven patients with confirmed chb in our hospital, a tertiary teaching hospital in china, between 2005 and 2014 were analyzed retrospectively. among 211 patients with chb, 35 were superinfected with hav, 31 were superinfected with ... | 2016 | 26509653 |
| tgf-β1 gene - 509c > t promoter polymorphism modulates tgf-β1 levels in hepatitis e patients. | elevated levels of transforming growth factor-β1 (tgf-β1) and its positive correlation with foxp3 expression in hepatitis e patients have indicated involvement of tgf-β1 in hepatitis e pathogenesis. the current study determined polymorphisms in tgf-β1 gene, plasma tgf-β1 levels and t effector (teff) cell proliferation and explored their association in a case control study. polymorphisms in three selected sites (- 509c > t, + 869t > c and + 915g > c) of tgf-β1 gene by pcr & restriction fragment l ... | 2015 | 26504745 |
| anti-hepatitis e antibody in hemodialysis patients in isfahan, iran: prevalence and risk factors. | many studies have been performed regarding the prevalence of hepatitis e in the general population, but there is controversial evidence for an increased risk of the infection in patients on maintenance hemodialysis (hd). | 2015 | 26500681 |
| evidence of autochthonous hepatitis e in a portuguese pediatric cohort, 1992-1995. | despite the growing importance of hepatitis e virus (hev) in industrialized countries, minimal attention has been given to autochthonous hev infection in children. the present study screened archived sera (n = 71) from a portuguese pediatric cohort collected in 1992-1995 for the presence of antibodies against hev, using enzyme immunoassays and immunodot. anti-hev igg was detected in two children and anti-hev igm in one, suggesting an acute hev infection. this shows that hev was circulating in th ... | 2016 | 26496362 |
| murine norovirus (mnv-1) exposure in vitro to the purine nucleoside analog ribavirin increases quasispecies diversity. | ribavirin is a pharmaceutical antiviral used for the treatment of rna virus infections including norovirus, hepatitis c virus, hepatitis e virus, lassa virus, respiratory syncytial virus, and rhinovirus. despite the drug's history and documented efficacy, the antiviral mechanism of ribavirin remains unclear. mechanisms proposed include depletion of the intracellular gtp pool, immunomodulatory effects, induction of error catastrophe, inhibition of viral polymerase activity, and/or inhibition of v ... | 2016 | 26494169 |
| hepatitis e virus antibody prevalence in hunters from a district in central germany, 2013: a cross-sectional study providing evidence for the benefit of protective gloves during disembowelling of wild boars. | in germany, 17% of the general human population have antibodies to hepatitis e virus (hev) (recomline hev-igg/igm immunoassay [mikrogen gmbh]). wild boars represent an animal reservoir for hev genotype 3, which is the common genotype in germany. we estimated the seroprevalence among hunters with contact to wild boars to identify factors that may be associated with past or present hev infection. | 2015 | 26493830 |
| hepatitis e virus infection activates signal regulator protein α to down-regulate type i interferon. | hepatitis e virus (hev) is a major cause of enterically transmitted acute hepatitis worldwide. however, the mechanism of hev replication is unclear. type i interferon is the first defense line of host against viral infection. signal regulator protein α (sirp-α) plays an important role in negative regulation of innate immunity. in the present study, hev infection significantly activated the expression of sirp-α and down-regulated phosphorylation of irf3, consequently resulted in suppression of ty ... | 2016 | 26492885 |
| neurologic disorders in immunocompetent patients with autochthonous acute hepatitis e. | neurologic disorders, mainly guillain-barré syndrome and parsonage–turner syndrome (pts), have been described in patients with hepatitis e virus (hev) infection in industrialized and developing countries. we report a wider range of neurologic disorders in nonimmunocompromised patients with acute hev infection. data from 15 french immunocompetent patients with acute hev infection and neurologic disorders were retrospectively recorded from january 2006 through june 2013. the disorders could be div ... | 2015 | 26490255 |