Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| genome-wide scan for metabolic syndrome and related quantitative traits in hong kong chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. | we conducted autosomal genome scans to map loci for metabolic syndrome (mes) and related traits in the hong kong family diabetes study. we selected 55 families with 137 affected members (121 affected relative pairs) for nonparametric linkage analysis on mes. we also selected 179 families with 897 members (2,127 relative pairs) for variance component-based linkage analyses on seven mes-related traits: waist circumference, systolic and diastolic blood pressure (bp), triglyceride, hdl cholesterol, ... | 2004 | 15448100 |
| transforming growth factor-beta1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in southern chinese women. | genetic contributions play an important role in determining bone mineral density (bmd) and bone turnover. transforming growth factor-beta (tgf-beta) is abundant in bone and has been implicated as an important regulator of both bone formation and resorption. several polymorphisms of the tgf-beta1 gene have recently been suggested to be associated with bmd and susceptibility to osteoporotic spine fractures. to determine the relationship between tgf-beta1 polymorphisms and bmd in southern chinese w ... | 2004 | 15354859 |
| the use of recombinant human epidermal growth factor (rhegf) in a gentleman with drug-induced steven johnson syndrome. | a case of drug-induced steven johnson syndrome in a gentleman is reported. its course of treatment with rhegf was compared to conventional treatment in historical control. | 2004 | 15347507 |
| associations between il12b polymorphisms and tuberculosis in the hong kong chinese population. | interleukin (il)-12 plays a vital role in regulating cell-mediated immunity against tuberculosis (tb). | 2004 | 15295696 |
| dioxin-like components in human breast milk collected from hong kong and guangzhou. | the h4iie rat hepatoma cell line was employed as a cell model to screen 7-ethoxyresorufin o-deethylase (erod)-tcdd equivalents (erod-teq) of human breast milk samples collected from hong kong and guangzhou, china. the screening methods employed a 96-well plate spectrofluorometer-erod assay. for cell-line validation, our results demonstrated a dose-dependent increase in the ah receptor-mediated response (i.e., cyp1a1 mrna and erod) of the cells upon exposure to a number of known ah receptor agoni ... | 2004 | 15261788 |
| breast milk substitutes in hong kong. | in 1981 the world health assembly (wha) adopted the international code of marketing of breast milk substitutes (the code) to support breastfeeding. despite improving trends, hong kong has low rates of breastfeeding compared to other developed countries. | 2004 | 15228560 |
| excess hospital admissions for pneumonia, chronic obstructive pulmonary disease, and heart failure during influenza seasons in hong kong. | it is widely held that southern china is a hypothetical influenza epicentre for the emergence of pandemic influenza viruses. however, influenza is perceived as a relatively unimportant infection in this part of the world compared with western countries. hong kong is situated within the hypothetical epicentre and serves as a sentinel post for the region. in a retrospective study, the influenza-associated excess hospitalisations in a regional hospital for pneumonia, chronic obstructive pulmonary d ... | 2004 | 15221909 |
| outcome of patients with positive epstein-barr virus serologic status in the absence of nasopharyngeal carcinoma in hong kong. | to evaluate the current clinical practice of follow-up and the outcomes of patients with raised epstein-barr virus (ebv) antibody levels but without pathological evidence of nasopharyngeal carcinoma (npc) for a possible risk of developing npc in the future. | 2004 | 15210561 |
| molecular diversity of epstein-barr virus igg and iga antibody responses in nasopharyngeal carcinoma: a comparison of indonesian, chinese, and european subjects. | epstein-barr virus (ebv)-specific immunoblot analysis was used to reveal the molecular diversity of immunoglobulin (ig) g and iga antibody responses against epstein-barr nuclear antigen (ebna), early antigen (ea), and viral capsid antigen (vca) in serum samples from patients with nasopharyngeal carcinoma (npc) and control subjects, by use of immunofluorescence assay (ifa). control donors (n=150) showed igg responses to few ebv proteins--vca-p18, vca-p40, ebna1, and zebra--and sporadically weak i ... | 2004 | 15195243 |
| stress and health-related quality of life among hiv-infected persons in hong kong. | this study examines the relationships among illness-related factors, stress, health-related quality of life (hrqol), and psychological distress in persons infected with the human immunodeficiency virus (hiv) living in hong kong (n = 55). participants completed questionnaires including a symptom checklist, modified hiv stressor scale (hivss), medical outcomes study short-form 36 (sf-36), and the hospital anxiety and depression scale (hads). in addition, cd4 count information was obtained. multipl ... | 2004 | 15187474 |
| use of an electronic barcode system for patient identification during blood transfusion: 3-year experience in a regional hospital. | to evaluate the use of an electronic barcode system for patient identification during blood transfusion. | 2004 | 15181220 |
| genome-wide scan for type 2 diabetes loci in hong kong chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. | we conducted an autosomal genome scan to map loci for type 2 diabetes in a hong kong chinese population. we studied 64 families, segregating type 2 diabetes, of which 57 had at least one member with an age at diagnosis of </=40 years. these families included a total of 126 affected sibpairs and 4 other affected relative pairs. nonparametric linkage analysis revealed seven regions showing nominal evidence for linkage with type 2 diabetes (logarithm of odds [lod] >0.59, p(pointwise) < 0.05): chrom ... | 2004 | 15161769 |
| [pay enough attention to human infection with avian influenza virus]. | 2004 | 15157379 | |
| h5n1 influenza: a protean pandemic threat. | infection with avian influenza a virus of the h5n1 subtype (isolates a/hk/212/03 and a/hk/213/03) was fatal to one of two members of a family in southern china in 2003. this incident was preceded by lethal outbreaks of h5n1 influenza in waterfowl, which are the natural hosts of these viruses and, therefore, normally have asymptomatic infection. the hemagglutinin genes of the a/hk/212/03-like viruses isolated from humans and waterfowl share the lineage of the h5n1 viruses that caused the first kn ... | 2004 | 15148370 |
| reemerging h5n1 influenza viruses in hong kong in 2002 are highly pathogenic to ducks. | waterfowl are the natural reservoir of all influenza a viruses, which are usually nonpathogenic in wild aquatic birds. however, in late 2002, outbreaks of highly pathogenic h5n1 influenza virus caused deaths among wild migratory birds and resident waterfowl, including ducks, in two hong kong parks. in february 2003, an avian h5n1 virus closely related to one of these viruses was isolated from two humans with acute respiratory distress, one of whom died. antigenic analysis of the new avian isolat ... | 2004 | 15078970 |
| oseltamivir prophylaxis during the influenza season in a paediatric cancer centre: prospective observational study. | to determine the role of oseltamivir prophylaxis for immunocompromised patients. | 2004 | 15075430 |
| non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma. | to present an institution's 2-year experience of non-myeloablative allogeneic stem cell transplantation among chinese patients. | 2004 | 15075426 |
| epstein-barr virus latent membrane protein 1 (lmp1) upregulates id1 expression in nasopharyngeal epithelial cells. | nasopharyngeal carcinoma is closely associated with epstein-barr virus (ebv) infection. the ebv-encoded lmp1 has cell transformation property. it suppresses cellular senescence and enhances cell survival in various cell types. many of the downstream events of lmp1 expression are mediated through its ability to activate nf-kappab. in this study, we report a novel function of lmp1 to induce id1 expression in nasopharyngeal epithelial cells (np69) and human embryonal kidney cells (hek293). the id1 ... | 2004 | 15064751 |
| responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines. | in response to the emergence of severe infection capable of rapid global spread, who will issue a pandemic alert. such alerts are rare; however, on feb 19, 2003, a pandemic alert was issued in response to human infections caused by an avian h5n1 influenza virus, a/hong kong/213/03. h5n1 had been noted once before in human beings in 1997 and killed a third (6/18) of infected people. the 2003 variant seemed to have been transmitted directly from birds to human beings and caused fatal pneumonia in ... | 2004 | 15064027 |
| [severe acute respiratory syndrome: a singular epidemic of viral pneumonia]. | infectious agent: the severe acute respiratory syndrome (sars) is a febrile pneumonia initially observed in china at the end of 2002. the infectious agent has rapidly been identified as a new coronavirus, baptised sars-associated coronavirus (cov-sars). transmission is inter-human, via respiratory particles mainly. clinical presentation and treatment: the clinical presentation is highly variable, from a mild fever to an acute respiratory distress syndrome. there is no specific treatment. ribavir ... | 2004 | 15041887 |
| consideration of highly active antiretroviral therapy in the prevention and treatment of severe acute respiratory syndrome. | we observed that 0 of 19 patients with human immunodeficiency virus type 1 (hiv-1) infection, including those with acquired immunodeficiency syndrome (aids), who were hospitalized together and who had close contact with 95 patients with severe acute respiratory syndrome (sars) on the same hospital floor contracted sars, whereas 6 of 28 medical workers who served on this floor contracted sars while caring for these patients. our investigation found that most of the patients with hiv-1/aids were r ... | 2004 | 15034838 |
| sars-related virus predating sars outbreak, hong kong. | using immunofluorescence and neutralization assays, we detected antibodies to human severe acute respiratory syndrome-associated coronavirus (sars-cov) and/or animal sars-cov-like virus in 17 (1.8%) of 938 adults recruited in 2001. this finding suggests that a small proportion of healthy persons in hong kong had been exposed to sars-related viruses at least 2 years before the recent sars outbreak. | 2004 | 15030679 |
| phenotypic alterations induced by the hong kong-prevalent epstein-barr virus-encoded lmp1 variant (2117-lmp1) in nasopharyngeal epithelial cells. | epstein-barr virus (ebv) is closely associated with nasopharyngeal carcinoma (npc), a common cancer in hong kong. the ebv-encoded lmp1 protein is believed to play an important role in cell transformation. we have previously identified a prevalent lmp1 variant (2117-lmp1) that is expressed in 86% of primary npc in hong kong. in this study, the biologic phenotypes induced by 2117-lmp1 were compared with those of the prototypic b95.8-lmp1 in an immortalized nasopharyngeal epithelial cell line, np69 ... | 2004 | 15027126 |
| overview on sars in asia and the world. | severe acute respiratory syndrome (sars) is the first major novel infectious disease to hit the international community in the 21st century. it originated in southern china in november 2002, reached hong kong in february 2003 and spread rapidly thereafter to 29 countries/regions on five continents. at the end of the epidemic, the global cumulative total was 8098 with 774 deaths. seven asian countries/regions were among the top ten on the list. mainland china and hong kong, sar, accounted for 87% ... | 2003 | 15018125 |
| risk factors affecting the severity of single vehicle traffic accidents in hong kong. | a population-based case-control study was conducted to examine factors affecting the severity of single vehicle traffic accidents in hong kong. in particular, single vehicle accident data of three major vehicle types, namely private vehicles, goods vehicles and motorcycles, which contributed to over 80% of all single vehicle accidents during the 2-year-period 1999-2000, were considered. data were obtained from the newly implemented traffic accident data system (trads), which was developed jointl ... | 2004 | 15003577 |
| auricular anthropometry of hong kong chinese babies. | to provide a database of the auricular measurements of chinese infants born in hong kong. | 2004 | 14989749 |
| re-emergence of fatal human influenza a subtype h5n1 disease. | human disease associated with influenza a subtype h5n1 re-emerged in january, 2003, for the first time since an outbreak in hong kong in 1997. patients with h5n1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [ip-10] and monokine induced by interferon gamma [mig]). taken together with a previous report that h5n1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokin ... | 2004 | 14987888 |
| epidemiology of hepatitis a and hepatitis e infection and their determinants in adult chinese community in hong kong. | current epidemiology of hepatitis a virus (hav) and hepatitis e virus (hev) in hong kong was evaluated in 936 adult chinese subjects recruited through a telephone interview in 2001. some 15% of the subjects had igg antibodies to both hav and hev while 665 (71.0%) and 176 (18.8%) had anti-hav and anti-hev, respectively. age was the most significant independent factor. six hundred thirty-eight (79.8%) and 165 (20.7%) subjects aged > or =30 had anti-hav and anti-hev, respectively, as compared with ... | 2004 | 14981755 |
| pb contamination and isotopic composition of urban soils in hong kong. | in the urban environment, intense human activities can lead to degradation of environmental quality and have potential long-term effects on human health. in the present study, pb contamination of urban soil cores in hong kong was investigated using a combination of the 'total' concentration, chemical partitioning and isotopic composition of pb in the soils. the analytical results showed that urban soil cores in close vicinity to high traffic volumes (> 40000 vehicles per day) were usually contam ... | 2004 | 14967510 |
| [sars (severe acute respiratory syndrome). emergent transmissible disease]. | of the reemergent transmissible diseases of the past decades, sars is probably not the last to express the alterations occurring in the relationships of the human being with its global ecosystem. the life of contemporary man is characterized, among others, by a huge thirst for traveling, for varied reasons, consequence of the globalization process. sars virus, mutant belonging to coronaviridae, occurred in one of the most densely populated areas of the world. there are two main moments marking t ... | 2003 | 14755924 |
| cerebrotendinous xanthomatosis in a hong kong chinese kinship with a novel splicing site mutation ivs6-1g>t in the sterol 27-hydroxylase gene. | we reported a hong kong chinese proband with cerebrotendinous xanthomatosis in which a novel acceptor splicing site mutation (ivs6-1g>t) was identified. family screening revealed the same mutation in his elder brother and the youngest sister. all the three affected siblings were compound heterozygous for ivs6-1g>t and a known missense mutation r372q (genbank accession no. m62401). significant phenotypic variation was noted among them that the youngest sister was still symptom-free at the time of ... | 2004 | 14741198 |
| wet markets--a continuing source of severe acute respiratory syndrome and influenza? | context: live-animal markets (wet markets) provide a source of vertebrate and invertebrate animals for customers in tropical and subtropical regions of the world. wet markets sell live poultry, fish, reptiles, and mammals of every kind. live-poultry markets (mostly chicken, pigeon, quail, ducks, geese, and a wide range of exotic wild-caught and farm-raised fowl) are usually separated from markets selling fish or red-meat animals, but the stalls can be near each other with no physical separation. ... | 2004 | 14738798 |
| identification of serum amyloid a protein as a potentially useful biomarker to monitor relapse of nasopharyngeal cancer by serum proteomic profiling. | nasopharyngeal cancer (npc) is a common cancer in hong kong, and relapse can occur frequently. using protein chip profiling analysis, we aimed to identify serum biomarkers that were useful in the diagnosis of relapse in npc. experimental design: profiling analysis was performed on 704 sera collected from 42 npc patients, 39 lung cancer patients, 30 patients with the benign metabolic disorder thyrotoxicosis (tx), and 35 normal individuals (nm). protein profile in each npc patient during clinical ... | 2004 | 14734450 |
| investigation of killer cell immunoglobulinlike receptor gene diversity: i. kir2dl4. | polymerase chain reaction-sequence-specific oligonucleotide probes typing procedures identifying alleles of the killer immunoglobulin-like gene (kir2dl4) have been established. the methods, designed around the specific amplification of the d0 and d2 domains of this gene, produce discrimination of kir2dl4 alleles. the methods have been applied to a healthy northern irish control group, establishing frequencies for this caucasian population. additionally, the kir2dl4 allele status of cell line dna ... | 2004 | 14700593 |
| common nod2 polymorphisms in hong kong chinese patients with systemic lupus erythematosus. | 2004 | 14681560 | |
| how are social identities linked to self-conception and intergroup orientation? the moderating effect of implicit theories. | social identity approaches assume that social identification affects both self-conception and intergroup orientation. the authors contend that such social identification effects are accentuated when people hold a fixed view of human character and attribute immutable dispositions to social groups. to these individuals, social identities are immutable, concrete entities capable of guiding self-conception and intergroup orientation. social identification effects are attenuated when people hold a ma ... | 2003 | 14674820 |
| a case of oral myiasis due to chrysomya bezziana. | chrysomya bezziana is a causative agent of obligatory myiasis. we report the first case of human infestation of chrysomya bezziana in hong kong in an 89-year-old woman who had previously had a stroke. one day after hospital admission for fever, a small fissure at the labial gingiva of the upper incisors and several ulcerative lesions at the hard palate were noticed during routine mouth care. a live maggot was seen protruding from the small fissure. in the following few days, a total of seven mag ... | 2003 | 14660813 |
| nuclear beta catenin as a potential prognostic and diagnostic marker in patients with colorectal cancer from hong kong. | to study the expression of nuclear beta catenin in patients with colorectal cancer, colorectal adenoma, and colorectal polyps to elucidate its role in carcinogenesis, and its potential for prognosis and diagnosis. | 2003 | 14645698 |
| risk assessment of exposure to volatile organic compounds in different indoor environments. | the lifetime cancer risks of exposure of cooks and food service workers, office workers, housewives, and schoolchildren in hong kong to volatile organic compounds (vocs) in their respective indoor premises during normal indoor activities were assessed. the estimated cancer risk for housewives was the highest, and the second-highest lifetime cancer risk to voc exposure was for the groups of food service and office workers. within a certain group of the population, the lifetime cancer risk of the ... | 2004 | 14643287 |
| assessing the impact of airline travel on the geographic spread of pandemic influenza. | the objective of this research is to explore what would happen if the hong kong influenza pandemic strain of 1968-1969 returned in 2000. we report the results of a series of simulations of an seir epidemic model coupled with air transportation data for 52 global cities. preliminary results suggest that if the 1968-1969 pandemic strain returned, it would spread concurrently to cities in both the northern and southern hemispheres thereby exhibiting less of the characteristic seasonal swing. in add ... | 2003 | 14620941 |
| hong kong's gloom and doom. | 2003 | 14607533 | |
| differences between influenza virus receptors on target cells of duck and chicken and receptor specificity of the 1997 h5n1 chicken and human influenza viruses from hong kong. | to study whether influenza virus receptors in chickens differ from those in other species, we compared the binding of lectins and influenza viruses with known receptor specificity to cell membranes and gangliosides from epithelial tissues of ducks, chickens, and african green monkeys. we found that chicken cells contained neu5ac alpha(2-6)gal-terminated receptors recognized by sambucus nigra lectin and by human viruses. this finding explains how some recent h9n2 viruses replicate in chickens des ... | 2003 | 14575133 |
| pathogenesis of and immunity to a new influenza a (h5n1) virus isolated from duck meat. | the outbreak of avian influenza h5n1 in hong kong in 1997 raised concerns about the potential for the h5 subtype to cause a human pandemic. in 2001 a new h5n1 virus, a/duck meat/anyang/avl-1/2001 (a/dkmt), was isolated from imported duck meat in korea. the pathogenesis of this virus was investigated in mice. a/dkmt virus had low infectivity but was lethal for mice at high doses, and at lethal doses, the virus replicated in the brains of infected mice. a/dkmt virus cross-reacted poorly with ferre ... | 2003 | 14575129 |
| generation and characterization of an h9n2 cold-adapted reassortant as a vaccine candidate. | h9n2 subtype avian influenza viruses have been identified in avian species worldwide, and infections in pigs were confirmed in hong kong in 1998. subsequently, h9n2 viruses were isolated from two children in hong kong in 1999, and five human infections were reported from china, raising the possibility that h9n2 viruses pose a potential pandemic threat for humans. these events prompted us to develop a vaccine candidate to protect humans against this subtype of influenza a viruses. reassortant h1n ... | 2003 | 14575127 |
| avian influenza in hong kong 1997-2002. | in 1997, a high-pathogenicity h5n1 avian influenza virus caused serious disease in both man and poultry in hong kong, china. eighteen human cases of disease were recorded, six of which were fatal. this unique virus was eliminated through total depopulation of all poultry markets and chicken farms in december 1997. other outbreaks of high-pathogenicity avian influenza (hpai) caused by h5n1 viruses occurred in poultry in 2001 and 2002. these h5n1 viruses isolated had different internal gene conste ... | 2003 | 14575073 |
| report on avian influenza in the eastern hemisphere during 1997-2002. | since the fourth international symposium on avian influenza (ai) there has been considerable ai activity in the eastern hemisphere. the higher profile of ai resulting from the human infections with h5n1 and h9n2 viruses in hong kong, in 1997 and 1999, respectively, resulted in increased reporting and active surveillance. there have been three reported incidents of high-pathogenicity (hp) ai: h5n2 in northeastern italy in 1997 (eight outbreaks); h5n1 in hong kong in 1997 recurring in 2001 and 200 ... | 2003 | 14575066 |
| human metapneumovirus detection in patients with severe acute respiratory syndrome. | we used a combination approach of conventional virus isolation and molecular techniques to detect human metapneumovirus (hmpv) in patients with severe acute respiratory syndrome (sars). of the 48 study patients, 25 (52.1%) were infected with hmpv; 6 of these 25 patients were also infected with coronavirus, and another 5 patients (10.4%) were infected with coronavirus alone. using this combination approach, we found that human laryngeal carcinoma (hep-2) cells were superior to rhesus monkey kidne ... | 2003 | 14519240 |
| mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male japanese workers. | increased mean corpuscular volume (mcv) is common in alcohol abusers and alcoholics. mcv is higher in japanese heavy drinkers with inactive aldehyde dehydrogenase-2 (aldh2) encoded by aldh2*1/2*2 than among those with active aldh2 encoded by aldh2*1/2*1. inactive aldh2 dramatically increases blood acetaldehyde levels after alcohol intake. because moderate and heavy drinkers with aldh2*1/2*2 have very high risks for esophageal cancer, mcv might serve as an indicator of these high-risk drinkers. | 2003 | 14506399 |
| influenza vaccine enlisted to prevent sars confusion. | 2003 | 13678898 | |
| genetic variation of glycoproteins b and h of human herpesvirus 7 in hong kong. | glycoprotein b (gb) and glycoprotein h (gh) of human herpesvirus 7 (hhv-7) are believed to play an important role in virus entry and as targets for host immune response. this study examined the genetic diversity of these glycoproteins among 90 hhv-7 isolates collected from different individuals in hong kong. overall, both the gb and gh genes were found to be highly conserved. nucleotide polymorphism was detected only at four positions of the gb-encoding region, and all of these were synonymous s ... | 2003 | 12966550 |
| facial anthropometry of hong kong chinese babies. | to provide a database of the craniofacial measurements of chinese infants born in hong kong. | 2003 | 12962199 |
| different optineurin mutation pattern in primary open-angle glaucoma. | the optineurin gene (optn) is the second gene besides myoc in which mutations have been identified to be associated with primary open-angle glaucoma (poag). in this study, sequence alterations in the optn gene associated with poag in chinese subjects were investigated. | 2003 | 12939304 |
| serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children. | chemokines are responsible for the trafficking of leukocytes to sites of inflammation. serum chemokine levels were previously shown to be increased in adult patients with atopic dermatitis (ad). we tested whether serum concentrations of chemokines, including macrophage-derived chemokine (mdc), thymus and activation-regulated chemokine (tarc), eotaxin (eox), interferon gamma inducible protein 10 (ip-10) and monocyte chemotactic protein 1 (mcp-1), are useful inflammatory markers for assessing ad s ... | 2003 | 12911508 |
| pitfalls in diagnosis of interstitial pregnancy. | to determine the incidence and reasons for misdiagnosis in interstitial ectopic pregnancy. | 2003 | 12911450 |
| hong kong under who spotlight after flu outbreak. | 2003 | 12907480 | |
| [severe acute respiratory syndrome: the first transmissible disease of the 21st century]. | the severe acute respiratory syndrome (sars) is the first severe and easily transmissible disease to emerge in the 21st century. it is caused by the infection with a coronavirus, a single strand rna capsulated virus, recently found in a small mammalian, the masked palm civet. it is likely to represent the source of human infection. the first cases of sars have been reported in the chinese province of guangdong and, since then, probable cases have been reported world wide. the clinical picture is ... | 2003 | 12868234 |
| a study of ozone variation trend within area of affecting human health in hong kong. | as far as the impact of air pollutants on human health being concerned, ozone is one of the main pollutants in atmosphere. in particular, the ground level ozone is responsible for a variety of adverse effects on both human being and plant life. to protect the humankind from such adverse health effects, early information and precautions of high ozone level need to be supplied in times. in this study, statistical characteristics of ground level ozone is analyzed according to the field monitoring d ... | 2003 | 12867170 |
| neurotropism of the 1997 hong kong h5n1 influenza virus in mice. | the direct transmission of h5n1 influenza a viruses from chickens to humans in hong kong in 1997 emphasized the need to have information on the pathogenesis of avian influenza virus infection in mammals. h5n1 influenza viruses isolated from patients during the incident killed experimentally infected mice. the principal lesions of the mice were broncho-interstitial pneumonia and nonsuppurative encephalitis. infectious viruses and/or viral antigens were detected in the brain as well as in the trig ... | 2003 | 12860072 |
| genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity. | adenocarcinoma of the lung is now the most common histologic subtype of non-small-cell lung cancer (nsclc) worldwide. in chinese populations, the incidence of lung adenocarcinoma is amongst the highest worldwide and its development in non-smoking females is particularly striking. information on the associated underlying genetic changes has been, however, minimal to date. the present study represents the first systematic analysis on the overall genetic changes in lung adenocarcinoma of chinese fe ... | 2003 | 12826317 |
| children with respiratory disease associated with metapneumovirus in hong kong. | human metapneumovirus (hmpv) is a newly discovered pathogen thought to be associated with respiratory disease. we report the results of a study of 587 children hospitalized with respiratory infection over a 13-month period. hmpv was detected in the nasopharyngeal aspirates from 32 (5.5%) children by reverse transcription-polymerase chain reaction. hmpv infection was associated with clinical diagnoses of pneumonia (36%), asthma exacerbation (23%), or acute bronchiolitis (10%). when compared to th ... | 2003 | 12781000 |
| transmission dynamics and control of severe acute respiratory syndrome. | severe acute respiratory syndrome (sars) is a recently described illness of humans that has spread widely over the past 6 months. with the use of detailed epidemiologic data from singapore and epidemic curves from other settings, we estimated the reproductive number for sars in the absence of interventions and in the presence of control efforts. we estimate that a single infectious case of sars will infect about three secondary cases in a population that has not yet instituted control measures. ... | 2003 | 12766207 |
| x-ray structure of the hemagglutinin of a potential h3 avian progenitor of the 1968 hong kong pandemic influenza virus. | we have determined the structure of the ha of an avian influenza virus, a/duck/ukraine/63, a member of the same antigenic subtype, h3, as the virus that caused the 1968 hong kong influenza pandemic, and a possible progenitor of the pandemic virus. we find that structurally significant differences between the avian and the human has are restricted to the receptor-binding site particularly the substitutions q226l and g228s that cause the site to open and residues within it to rearrange, including ... | 2003 | 12758169 |
| prediction of maximum daily ozone level using combined neural network and statistical characteristics. | analysis and forecasting of air quality parameters are important topics of atmospheric and environmental research today due to the health impact caused by air pollution. as one of major pollutants, ozone, especially ground level ozone, is responsible for various adverse effects on both human being and foliage. therefore, prediction of ambient ozone levels in certain environment, especially the ground ozone level in densely urban areas, is of great importance to urban air quality and city image. ... | 2003 | 12742398 |
| ebv specific antibody-based and dna-based assays in serologic diagnosis of nasopharyngeal carcinoma. | we assessed 5 ebv specific assays for their capacity to effect serologic diagnosis of suspected npc. the assays were the immunofluorescent assays, vca iga and ea iga, the enzyme-linked immunosorbent assays specific for ebna 1 iga or zta igg and an ebv dna assay. serum samples were taken from 218 symptomatic npc patients presenting consecutively at a public hospital in hong kong, 51 of whom were subsequently diagnosed as having npc; 4 had ebv-associated lung cancer with similar serology as npc. t ... | 2003 | 12740922 |
| infectious diseases. up close and personal with sars. | 2003 | 12738826 | |
| multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, burkholderia pseudomallei and burkholderia mallei. | a collection of 147 isolates of burkholderia pseudomallei, b. mallei, and b. thailandensis was characterized by multilocus sequence typing (mlst). the 128 isolates of b. pseudomallei, the causative agent of melioidosis, were obtained from diverse geographic locations, from humans and animals with disease, and from the environment and were resolved into 71 sequence types. the utility of the mlst scheme for epidemiological investigations was established by analyzing isolates from captive marine ma ... | 2003 | 12734250 |
| epidemiology, clinical presentation and laboratory investigation of severe acute respiratory syndrome (sars) in canada, march 2003. | as of 23 march, 2003, 11 cases of sars have been reported in canada. three patients had travelled to china, including hong kong sar. the remaining eight had a history of close contact with cases. there have been three deaths. to date, evidence for human metapneumovirus has been found in six cases; further studies are ongoing to determine whether this virus is the causative agent of the sars or whether other, so far undetected, pathogens are responsible. public health measures are being implement ... | 2003 | 12710251 |
| ecological restoration of mine degraded soils, with emphasis on metal contaminated soils. | this paper reviews the ecological aspects of mined soil restoration, with special emphasis on maintaining a long-term sustainable vegetation on toxic metal mine sites. the metal mined soils are man-made habitats which are very unstable and will become sources of air and water pollution. establishment of a vegetation cover is essential to stabilize the bare area and to minimize the pollution problem. in addition to remediate the adverse physical and chemical properties of the sites, the choice of ... | 2003 | 12688490 |
| the next influenza pandemic: lessons from hong kong. | pandemic influenza is a zoonosis. studies on influenza ecology conducted in hong kong since the 1970s in which hong kong essentially functioned as an influenza sentinel post indicated that it might be possible, for the first time, to have influenza preparedness at the baseline avian level. this appreciation of influenza ecology facilitated recognition of the h5n1 'bird flu' incident in hong kong in 1997 in what was considered to be an incipient pandemic situation, the chicken being the source of ... | 2003 | 12675938 |
| the first patient with locally acquired dengue fever in hong kong. | this report is of the first locally acquired case of dengue fever. the diagnosis was made even in the absence of a history of travel outside hong kong. the patient was a 21-year-old man, who presented with high fever, leukopenia, thrombocytopenia, and elevated liver enzymes. his haematocrit revealed mild haemoconcentration but the albumin was normal throughout the course of the illness. his blood pressure remained low with no tachycardia or overt shock syndrome. the pyrexia subsided 4 days after ... | 2003 | 12668825 |
| clinical profiles of human immunodeficiency virus-associated lymphoma in hong kong. | to identify the clinical and prognostic features of human immunodeficiency virus-associated lymphoma in the local population with a view to designing more effective treatment strategies. | 2003 | 12668818 |
| tuberculosis in hong kong-patient characteristics and treatment outcome. | to identify the general characteristics of patients with tuberculosis, and to evaluate their treatment outcomes. | 2003 | 12668817 |
| voluntary hiv antibody testing amongst youth in hong kong. | we performed a study to estimate the prevalence of and factors associated with human immunodeficiency virus (hiv) antibody-testing behaviour among youth in hong kong. it was a population-based cross-sectional study. questions on hiv testing were asked as part of a youth sexuality study conducted in july to december 1996 among young adults in hong kong. a total of 517 (53.6%) males and 447 (46.4%) females aged 17 to 28 years completed an anonymous structured self-administered questionnaire. respo ... | 2003 | 12662393 |
| strong association between n-acetyltransferase 2 genotype and pd in hong kong chinese. | the slow acetylator genotype for n-acetyltransferase 2 (nat2 genotype) may be associated with pd in white subjects and the genotype is common in both white and chinese populations. whether there is a relationship between nat2 genotype and pd in chinese subjects is not known. | 2003 | 12654968 |
| trisomy 21 and other chromosomal abnormalities in acute promyelocytic leukemia. | we describe a case of acute promyelocytic leukemia (apl) with t(15;17)(q22;q12) and trisomy 21 as an additional change in a patient who died at relapse after achieving complete remission (cr) for the duration of 20 months. a survey of 42 cases of apl with cytogenetic study performed at our institutionover the past 10 years showed 12 cases (28.6%) having chromosomal changes in addition to t(15;17). trisomy 8 and trisomy 21 as additional changes were noted in 4 and 2 cases, respectively, with one ... | 2003 | 12645658 |
| hong kong chinese family caregiving: cultural categories of bodily order and the location of self. | this ethnographic study entailed interviews and observations over 2 years involving 35 hong kong chinese families caring for elderly coresidential members. bodily disorder was a starting point from which to locate identifiably chinese attempts to restore disrupted family relations. themes included bodies out of order--challenging confucian-informed models of family obligation; controlling bodily excretions; the body in decay; and the body as the location of self. the management of bodily order b ... | 2003 | 12643026 |
| infectious disease. an avian flu jumps to people. | 2003 | 12624244 | |
| invasive streptococcus iniae infections outside north america. | streptococcus iniae, a fish pathogen causing infections in aquaculture farms worldwide, has only been reported to cause human infections in north america. in this article, we report the first two cases of invasive s. iniae infections in two chinese patients outside north america. while the first patient presented with bacteremic cellulitis, which is the most common presentation in previous cases, the second patient represents the first recognized case of s. iniae osteomyelitis. both s. iniae str ... | 2003 | 12624022 |
| tgfbeta-induced factor: a candidate gene for high myopia. | to investigate the coding exons of transforming growth factor (tgf)-beta-induced factor (tgif) for mutations in chinese patients with high myopia. | 2003 | 12601022 |
| familial high myopia linkage to chromosome 18p. | a locus for autosomal dominant high myopia was reported on chromosome 18p. we sought to confirm this finding and narrow the reported interval by analyzing high myopia among families of hong kong chinese, in whom myopia is common. in 15 families with a possibly autosomal dominant inheritance of high myopia (>or=-6 dpt) in at least 2 generations, 10 chromosome 18p markers were analyzed for linkage with high myopia. two-point linkage analysis showed trends toward linkage of markers d18s476 and d18s ... | 2003 | 12592049 |
| abca4 sequence variants in chinese patients with age-related macular degeneration or stargardt's disease. | abca4 gene sequence alterations cause stargardt's disease (stgd) and may cause some age-related macular degeneration (amd). we sought to shed light on these associations among hong kong chinese by genotyping 140 amd, 18 stgd and 95 normal control subjects for 15 abca4 exons which were reported to often contain amd- or stgd-associated mutations. sequence alterations r212h, t1428m, v1433i, t1572m, i2166m, ivs6-5t>g and ivs33+1g>t were found in amd patients. t1428m and r2040x occurred in stgd patie ... | 2003 | 12592048 |
| effects of training and experience on perception of hazard and risk. | this study was designed to show how those proficient at a machining task, where proficiency was gained through both training and past experience, influence the perceived hazard and risk when observing computer numerical control (cnc) machining. the study was also designed to determine whether the impact of the visual and auditory cues can be isolated during diagnosis of the hazard. in a study that included 40 participants, results show that trained observers can perceive more correctly a hazardo ... | 2003 | 12554401 |
| sex differences on the progressive matrices: some data from hong kong. | there has been a debate between n. j. mackintosh and the first author of this paper on whether the sex difference on the progressive matrices is zero or, at most, 1-2 iq points in favour of either sex, as maintained by mackintosh, or whether from the age of 15 years onwards males obtain higher average scores than females by more than 2 iq points, as maintained by lynn. new data relevant to this controversy are presented from hong kong consisting of sex differences on the standardization sample o ... | 2003 | 12537162 |
| memoir on hepatitis and liver disease history in hong kong. | 2002 | 12534791 | |
| comparison of dioxin and pcb concentrations in human breast milk samples from hong kong and the netherlands. | the adverse effects of dioxins and polychlorinated biphenyls (pcbs) on human health are of increasing concern. these lipophilic compounds are concentrated through the food chain and are present in human milk. this study compares pcb levels in human milk samples from hong kong and dutch mothers. ten breast milk samples from hong kong and 10 from the netherlands were collected during home visits between 2 and 6 weeks postpartum. total toxic equivalence (teq) of dioxin and pcbs were determined usin ... | 2003 | 12519720 |
| determination of total potentially available nucleosides in human milk from asian women. | the objective was to measure the total potentially available nucleosides (tpan) in breast milk from asian women. | 2003 | 12507633 |
| a preliminary study of ozone trend and its impact on environment in hong kong. | as far as the impact of air pollutants on human health being is concerned, ozone (o3) is one of the most pollutant sources, and, in particular, the ground level ozone is responsible for a variety of adverse effects on both human being and plant life. to protect the population from such adverse health effects, early information and precautions about the high ozone level need to be ascertained. in this study, statistical characteristics of ground level ozone is analyzed according to field monitori ... | 2002 | 12503916 |
| the global implications of influenza in hong kong. | 2002 | 12501229 | |
| influenza-related hospitalizations among children in hong kong. | it has been difficult to define the burden of influenza in children because of confounding by the cocirculation of respiratory syncytial virus (rsv). in hong kong, china, the influenza and rsv infection seasons sometimes do not overlap, thus providing an opportunity to estimate the rate of influenza-related hospitalization in a defined population, free from the effects of rsv. | 2002 | 12501221 |
| animal research, non-vegetarianism, and the moral status of animals--understanding the impasse of the animal rights problem. | i offer some reasons for the theory that, compared with human beings, non-human animals have some but lesser intrinsic value. on the basis of this theory, i first argue that we do not know how to compare an animal's claim to be free from a more serious type of harm (e.g., death), and a human's claim to be free from some lesser type of harm (e.g., non-fatal morbidity). for we need to take account of these parties' intrinsic value, and their competing types of claim. yet, there exists no known way ... | 2002 | 12461712 |
| experience with the clinical development of influenza vaccines for potential pandemics. | during normal interpandemic influenza seasons, immune responses to vaccines are quite predictable and meet the licensing criteria of the european union (eu) committee for proprietary medicinal products (cpmp). in a pandemic situation, large sections, if not all of the community will be immunologically naïve and therefore new immunisation strategies will be needed. in 1976 and 1977 h1n1 vaccines were prepared and tested clinically. to stimulate 'protective' antibody responses, two doses of vaccin ... | 2002 | 12458360 |
| hong kong flu still poses pandemic threat. | 2002 | 12435238 | |
| chinese cultural dynamics of unemployability of male adults with psychiatric disabilities in hong kong. | work and employment has long been regarded as crucial for the mental health of human beings. unemployment may lead to deterioration of physical and mental health. nevertheless, for adults with psychiatric disabilities, discontinuity of employment is common. they may have various reasons to discontinue their employment. in hong kong, only 2.5% of people with psychiatric disabilities discharged from sheltered workshops are able to seek open employment. by means of illustration, the authors will sh ... | 2002 | 12433223 |
| extra-pulmonary and pulmonary tuberculosis in hong kong. | to compare the characteristics of patients with pulmonary and extra-pulmonary tuberculosis and to describe the organ involvement, diagnosis and treatment of extra-pulmonary tuberculosis. | 2002 | 12365574 |
| a profile of hong kong population analysed by district board district, 1998. | the demographic and socioeconomic characteristics of the population of hong kong are analyzed at the district board level as at mid-1998 using official data. data are included on population size, sex and age distribution, educational status, and labor force participation. | 1999 | 12349035 |
| [immigration and economic development in eastern asia]. | this work describes recent trends in east asian migration and their economic effects. the great waves of emigration of the past have largely ceased from japan and the "dragons" of east asia, and all have become countries of illegal immigration, return of emigrants, and legal entry of professionals. all the countries except hong kong have maintained strict immigration policies in order to protect their traditional and homogeneous societies and the employment and income of their own citizens. b ... | 1994 | 12346374 |
| hong kong and its hinterland: a case of international rural-to-urban migration? | "the historical background of migration to hong kong from china is reviewed. the focus is, however, on the 'wave' of migration that occurred in the late 1970s. two distinct streams of migration are identified, legal and illegal, each with different characteristics." data are primarily from official hong kong sources. the author notes the high levels of education among immigrants and the relative ease with which they have been absorbed into the labor force. "political conditions in china are ... | 1986 | 12341325 |
| a migration channels approach to the study of professionals moving to and from hong kong. | "this article evaluates the concept of migration channels, identifying the strengths and weaknesses that have emerged from use of a migration channels framework in international migration research. using professional migration to and from hong kong in the 1990s as an empirical lens, it is argued that the meso-scale understanding offered by examining the effect of migration channels is valuable. this is illustrated in terms of the contrasting channels used by different professions, as well by mig ... | 1998 | 12293996 |
| characteristics and assimilation of chinese immigrants in the u.s. labour market. | "using u.s. public use samples, this article examines differences in the quality and assimilation rate of different chinese immigrant groups (immigrants from hong kong, taiwan and mainland china) in the u.s. labour market. the descriptive statistics show great differences among chinese immigrants from the three areas in their ages, wage rates, years of schooling and industrial and occupational distributions. this article also finds that the three chinese immigrant groups have much more disperse ... | 1998 | 12293795 |
| skilled hong kong immigrants' intention to repatriate. | "an emphasis on skills in australian immigration policy in the past decade has led to the increase of highly skilled hong kong immigrants. however, australia has not been able to retain all of them.... this paper reports the results of an in-depth study on intention to repatriate and work in hong kong, conducted in australia with 111 professional and managerial hong kong immigrants. correlational and loglinear analyses on prediction of such an intention are presented. research findings on the ... | 1997 | 12293142 |