Publications

letter: asymptomatic non-fatal canine rabies.		1975	47030
[rabies specific igm- and igg-antibody response in persons immunized with hdcs vaccine according to the essen postexposure vaccination schedule (author's transl)].	a solid phase enzyme immunoassay (elisa) was applied for the determination of rabies virus antibodies of the immunoglobulin classes g and m in sera of 10 young adults. vaccinations were carried out with the essen post-exposure vaccination schedule, which is recommended by the w.h.o., with the rabies hdcs vaccine with an antigen value of 1.9. from these results the rabies virus igm/igg-conversion was derived. furthermore a comparison was carried out of results obtained with the elisa, the mouse n ...	1979	44937
[interferon induced in the hamster by subunits of "nocardia": essay of protection against rabies (author's transl)].	lipid-free cells of nocardia opaca and a cell extract (nwsm) are interferon inducers in syrian hamsters: peak interferon appears 2 h after injection as compared to 8 h in the case of interferon induced by inactivated ndv virus. the interferon induced by nocardia product is inactivated by a treatment for 30 min at 56 degrees c or 24 h at ph 2: ndv-induced interferon is more stable under these conditions. hamsters inoculated with nwsm before and after infection with rabies virus are partially prot ...	1979	43690
early events in non-lethal rabies infection.	inoculation of sublethal doses of rabies virus strains isolated from small wild rodents resulted in non-lethal infection of white mice. during the first 48 hr after inoculation the virus neutralizing and protection activities in mouse sera and brain suspensions increased, followed by a transient decrease on the 3rd and 4th day. in some cases there also occurred transient multiplication of virus, which retained a relatively high infectivity for mice.	1979	40421
chronic form of experimental rabies in mice.	the l-28 strain of street rabies virus isolated from the salivary gland of a red fox caused chronic infection in mice. after intracerebral (i.e.) infection with virus-containing fox salivary gland suspension, 13.9% of mice showed clinical signs of disease for 11--52 days. clear-cut stages of irritation and paralysis were distinguished in the course of infection of mice. the diagnosis of chronic rabies in mice was confirmed by immunofluorescence and isolation of virus by i.c. inoculation of mice. ...	1979	39437
allergic encephalitis, rabies antibodies, and the blood/brain barrier.	similarity of the syndromes of rabies and of encephalomyelitis resulting from rabies vaccination poses a problem in differential diagnosis that has had tragic consequences. that difficulty may also be largely responsible for the traditional belief that rabies is inexorably fatal, in that recovery from paralysis is interpreted as evidence that the disease was postvaccinal encephalomyelitis rather than rabies. diagnosis is additionally complicated by presence of rabies antibodies in serum in both ...	1979	38289
an rna polymerase activity in purified rabies virions.	an rna polymerase activity has been demonstrated in purified rabies virions. efficiency of the reaction is low since the rate of incorporation was equal to 3 to 5 pmol of uridine per hour, per mg of protein. as with other mammalian rhabdoviruses the optimal temperature was 31 degrees c. unlike vesicular stomatitis virus, manganese could be substituted for magnesium as a divalent cation, at an optimum concentration of 10 to 20 mm.	1978	29077
application of a tricin-buffered modification of the cmrl-1969 medium in cell and virus cultivation (author's transl).	cmrl-1969 medium (healy et al., 1971) was modified by using 0.02 molar n-tris-(hydroxymethyl)-methyl-glycin (= tricin) instead of bicarbonate as the buffer substance. several permanent cell lines and primary cell cultures did not show growth differences in the two medium variants. like other non volatile buffers tricin abolishes the initial increase of the ph in freshly split or newly fed closed vessel cultures, but in 0.02 m concentration maintains the same buffering capacity of the medium as c ...	1977	24962
transcriptase activity associated with rabies virion.	rabies virion-associated transcriptase activity was investigated in vitro and compared with that of the new jersey serotype of vesicular stomatitis virus. the concentration of detergent that affected 3hgmp incoporation into acid-insoluble material was significantly different for both viruses. vesicular stomatitis virus new jersey required 0.05 to 0.1% nonionic detergent, whereas rabies virion could not be fully activated unless 4 to 5% detergent was used. other optimal conditions were as follows ...	1977	22766
comparison of the ribonucleoproteins of different rabies virus serotypes by radioimmunoassay.	radioimmunoassay (ria) provides a sensitive serological procedure for detecting rabies virus ribonucleoprotein (rnp) as well as its specific antibodies, ria was carried out using highly purified rnps labelled by the chloramine-t method. this paper describes optimal conditions for iodination of rnp with high specific activity. the optimal concentrations of 125i, rnp, chloramine-t, and reducing agent as well as the effect of ph on the reaction were investigated. ria proved to be extremely sensitiv ...	1977	22569
possible role of measles, rubella and mumps viruses in multiple sclerosis.		1977	17282
rabies glycoprotein purification by isoelectric focusing (author's transl).	a glycoprotein was extracted with triton x100 from rabies virus grown in primary foetal bovine kidney cells. this glycoprotein was further purified by iso electro focusing and showed a major peak at ph 7,0 and a smaller peak at ph 4,6. purified fractions were migrated on polyacrylamide gels and assayed for immunogenicity.	1976	14578