Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [first research work by robert koch on etiology of anthrax-in cooperation with józef knechtel, polish apothecary]. | terroristic attack on united states of america 11 september 2001 and just after many cases of anthrax spores employment as biological warfare called our attention to robert koch. he determined anthrax etiology and enclosed it in his first research work: die aetiologie der milzbrand-kranheit begrundet auf die entwicklungsgeschichte des bacillus anthracis. the results of this research are widely described. in the scientific researches participated j. knechtel, pole, pharmacist, pharmacy owner in w ... | 2003 | 14565192 |
| morphogenesis of bacillus spore surfaces. | spores produced by bacilli are encased in a proteinaceous multilayered coat and, in some species (including bacillus anthracis), further surrounded by a glycoprotein-containing exosporium. to characterize bacillus spore surface morphology and to identify proteins that direct formation of coat surface features, we used atomic-force microscopy (afm) to image the surfaces of wild-type and mutant spores of bacillus subtilis, as well as the spore surfaces of bacillus cereus 569 and the sterne strain ... | 2003 | 14563859 |
| differential processing of cd4 t-cell epitopes from the protective antigen of bacillus anthracis. | we have mapped cd4+ t-cell epitopes located in three domains of the recombinant protective antigen of bacillus anthracis. mouse t-cell hybridomas specific for these epitopes were generated to study the mechanisms of proteolytic processing of recombinant protective antigen for antigen presentation by bone marrow-derived macrophages. overall, epitopes differed considerably in their processing requirements. in particular, the kinetics of presentation, ranging from 15 (fast) to 120 min (slow), sugge ... | 2003 | 14561737 |
| statistical analysis of microarray data: a bayesian approach. | the potential of microarray data is enormous. it allows us to monitor the expression of thousands of genes simultaneously. a common task with microarray is to determine which genes are differentially expressed between two samples obtained under two different conditions. recently, several statistical methods have been proposed to perform such a task when there are replicate samples under each condition. two major problems arise with microarray data. the first one is that the number of replicates ... | 2003 | 14557114 |
| anthrax--cdc review. | 2003 | 14556368 | |
| cutaneous anthrax in adults: a review of 25 cases in the eastern anatolian region of turkey. | the clinical features, therapy and outcome of anthrax cases from the elazig province (the eastern anatolian region) of turkey seen in our clinic over an 8-year period were reviewed. | 2003 | 14556058 |
| human antibodies from immunized donors are protective against anthrax toxin in vivo. | a panel of fabs that neutralize anthrax toxin in vitro was selected from libraries generated from human donors vaccinated against anthrax. at least two of these antibodies protect rats from anthrax intoxication in vivo. fabs 83k7c and 63l1d bind with subnanomolar affinity to protective antigen (pa) 63, and fab 63l1d neutralizes toxin substoichiometrically, inhibits lethal factor (lf) interaction with pa63 and binds to a conformational epitope formed by pa63. | 2003 | 14555959 |
| prevention and treatment of bacterial diseases caused by bacterial bioterrorism threat agents. | there is general consensus that the bacterial agents or products most likely to be used as weapons of mass destruction are bacillus anthracis, yersinia pestis, francisella tularensis and the neurotoxin of clostridium botulinum. modern supportive and antimicrobial therapy for inhalational anthrax is associated with a 45% mortality rate, reinforcing the need for better adjunctive therapy and prevention strategies. pneumonic plague is highly contagious, difficult to recognize and is frequently fata ... | 2003 | 14554016 |
| novel protein targeted therapy of metastatic melanoma. | metastatic melanoma patients have a dismal prognosis with poor responsiveness to chemotherapy, radiation therapy and current immunotherapy regimens and a median survival of less than six months. novel therapies directed at melanoma-selective molecular targets are urgently needed. based on the frequent constitutive activation of the mitogen-activated protein kinase (mapk) signaling pathway in malignant melanomas and the selective inhibition of mapk signaling by anthrax lethal factor which proteol ... | 2003 | 14552326 |
| a new world order for human experiments. | 2003 | 14552300 | |
| anthrax toxin induces hemolysis: an indirect effect through polymorphonuclear cells. | anthrax toxin can induce hemolysis in the presence of polymorphonuclear cells (pmns), an activity primarily mediated by protective antigen, with synergic effects provided by lethal factor and edema factor. lethal factor and edema factor, individually or in combination, are incapable of lysing red blood cells. the requirement for the presence of pmns indicates that hemolysis associated with bacillus anthracis infection is indirect rather than direct, as observed in many other bacterial infections ... | 2003 | 14551883 |
| molecular characterization of anthrax in positive powders: a mexican experience. | 2003 | 14532260 | |
| use of denaturing high-performance liquid chromatography to identify bacillus anthracis by analysis of the 16s-23s rrna interspacer region and gyra gene. | denaturing high-performance liquid chromatography (dhplc) was evaluated as a method for identifying bacillus anthracis by analyzing two chromosomal targets, the 16s-23s intergenic spacer region (isr) and the gyra gene. the 16s-23s isr was analyzed by this method with 42 strains of b. anthracis, 36 strains of bacillus cereus, and 12 strains of bacillus thuringiensis; the gyra gene was analyzed by this method with 33 strains of b. anthracis, 27 strains of b. cereus, and 9 strains of b. thuringiens ... | 2003 | 14532217 |
| species-specific peptide ligands for the detection of bacillus anthracis spores. | currently available detectors for spores of bacillus anthracis, the causative agent of anthrax, are inadequate for frontline use and general monitoring. there is a critical need for simple, rugged, and inexpensive detectors capable of accurate and direct identification of b. anthracis spores. necessary components in such detectors are stable ligands that bind tightly and specifically to target spores. by screening a phage display peptide library, we identified a family of peptides, with the cons ... | 2003 | 14532093 |
| innate immunity and biodefence vaccines. | host defence in vertebrates is achieved by the integration of two distinct arms of the immune system: the innate and adaptive responses. the innate response acts early after infection (within minutes), detecting and responding to broad cues from invading pathogens. the adaptive response takes time (days to weeks) to become effective, but provides the fine antigenic specificity required for complete elimination of the pathogen and the generation of immunologic memory. antigen-independent recognit ... | 2003 | 14531891 |
| detection of the sentinel anthrax case in the united states. | first-hand knowledge of the detection of the first bioweapon in modern united states history is described in this article. the method by which the presumptive diagnosis of anthrax meningitis was made within 13 hours of the patient presenting to the emergency department is described using pre-analytic, analytic, and post-analytic phases. the lessons learned from this process are briefly presented so that other laboratories may learn from our experience: how to prepare; how to quickly analyze a po ... | 2003 | 14531222 |
| advances in molecular-based diagnostics in meeting crop biosecurity and phytosanitary issues. | awareness of crop biosecurity and phytosanitation has been heightened since 9/11 and the unresolved anthrax releases in october 2001. crops are highly vulnerable to accidental or deliberate introductions of crop pathogens from outside u.s. borders. strategic thinking about protection against deliberate or accidental release of a plant pathogen is an urgent priority. rapid detection will be the key to success. this review summarizes recent progress in the development of rapid real-time pcr protoc ... | 2003 | 14527331 |
| anthrax: lessons learned from the u.s. capitol experience. | 2003 | 14527185 | |
| [bacillus anthracis and anthrax]. | 2003 | 14524244 | |
| follow-up of deaths among u.s. postal service workers potentially exposed to bacillus anthracis--district of columbia, 2001-2002. | in october 2001, two letters contaminated with bacillus anthracis spores were processed by mechanical and manual methods at the u.s. postal service (usps) brentwood mail processing and distribution center in the district of columbia. four postal workers at the brentwood facility became ill with what was diagnosed eventually as inhalational anthrax; two died. the facility was closed on october 21, and postexposure prophylaxis was recommended for approximately 2,500 workers and business visitors. ... | 2003 | 14523371 |
| the growing pains of biodefense. | 2003 | 14523029 | |
| toxin-induced resistance in bacillus anthracis lethal toxin-treated macrophages. | in the current study, we show that macrophages adaptively resist anthrax lethal toxin (lt) through a toxin-activated process termed toxin-induced resistance (tir). tir was triggered by pretreatment of raw 264.7 or j774a.1 macrophages with a low dose of lt for at least 6 h, which resulted in resistance to high doses of lt for 96 h. activation of tir required functional toxin, because lt subunits, mutants, and heat-inactivated toxin were unable to trigger resistance. tir macrophages were not alter ... | 2003 | 14519843 |
| anthrax: forms, symptoms and treatment. | background: this article examines the history of anthrax, the organism, the different forms of human anthrax, its symptoms and treatment. set against fears of a bioterrorist attack, the article also examines the potential threat of anthrax as a weapon. conclusion: frontline staff such as nurses can contribute greatly to increasing survival by recognising symptoms, treating patients promptly and helping to allay public concern. | 2003 | 14515539 |
| calls about anthrax to the texas poison center network in relation to the anthrax bioterrorism attack in 2001. | between october 4, 2001 and november 20, 2001, 22 cases of anthrax were identified in a bioterrorism attack on the us. this study examined the patterns of anthrax calls before and after the bioterrorist attack based on calls received by poison centers in texas, a state that reported no anthrax cases as a result of the attack. during 1998-2002, 553 calls about anthrax were received. the majority of the anthrax calls occurred in 2001 (n = 489, 88.4%) and 2002 (n = 52, 9.4%). the number of calls in ... | 2003 | 14513892 |
| molecular diagnostic techniques for use in response to bioterrorism. | the use of micro-organisms as agents of biological warfare is considered inevitable for several reasons, including ease of production and dispersion, delayed onset of symptoms, ability to cause high rates of morbidity and mortality and difficulty in diagnosis. therefore, the clinical presentation and pathogenesis of the organisms posing the highest threat (variola major, bacillus anthracis, yersinia pestis, clostridium botulinum toxin, francisella tularensis, filoviruses, arenaviruses and brucel ... | 2003 | 14510181 |
| mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. | juvenile hyaline fibromatosis (jhf) and infantile systemic hyalinosis (ish) are autosomal recessive conditions characterized by multiple subcutaneous skin nodules, gingival hypertrophy, joint contractures, and hyaline deposition. we previously mapped the gene for jhf to chromosome 4q21. we now report the identification of 15 different mutations in the gene encoding capillary morphogenesis protein 2 (cmg2) in 17 families with jhf or ish. cmg2 is a transmembrane protein that is induced during capi ... | 2003 | 14508707 |
| binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions. | the secreted protein toxin produced by bacillus anthracis contributes to virulence of this pathogen and can cause many of the symptoms seen during an anthrax infection, including shock and sudden death. the cell-binding component of anthrax toxin, protective antigen, mediates entry of the toxin into cells by first binding directly to the extracellular integrin-like inserted (i) domain of the cellular anthrax toxin receptor, atr. here we report that this interaction requires an intact metal ion-d ... | 2003 | 14507921 |
| 'we're looking for zebras now'. | 2003 | 14507083 | |
| using a structured medical note for determining the safety profile of anthrax vaccine for us soldiers in korea. | selected military personnel are immunized with an fda-licensed anthrax vaccine unless there are clinical contraindications. the objective of this analysis is to capture the experience of soldiers receiving anthrax vaccine to assist in better patient-provider communication and clarify the safety profile of the vaccine in this population as a quality-assurance initiative. between august 1998 and july 1999, 2824 soldiers immunized against anthrax at one military clinic completed a structured medica ... | 2003 | 14505923 |
| when bioterrorism strikes: diagnosis and management of inhalational anthrax. | in october and november, 2001, reports of patients with inhalational anthrax reacquainted the public with this ancient disease and introduced the harsh reality of a bioterrorist act. bacillus anthracis, a rod-shaped, spore-forming bacterium, primarily infects herbivores. humans traditionally have acquired the disease from occupational or agricultural exposure to infected animals and animal products. recent events saw the intentional release of anthrax spores, using the u.s. postal system as an u ... | 2003 | 14505276 |
| inhalational anthrax: radiologic and pathologic findings in two cases. | 2003 | 14500233 | |
| [a case of anthrax of the skin]. | 1961 | 14481735 | |
| pathophysiological investigations into the terminal course of experimental anthrax in the rabbit. | 1961 | 14480282 | |
| [penicillin-produced changes in bac. anthracis. i. attempted production of the l-form bacteria]. | 1962 | 14479097 | |
| [changes produced by penicillin in bacillus anthracis. ii. appearance of coccal variants]. | 1962 | 14479096 | |
| [on the terminal groupings of the immuno-specific polysaccharide of bacillus anthracis]. | 1962 | 14472991 | |
| [anthrax morbidity among the inhabitants of the precaucasian and transcaucasian republics and its control]. | 1962 | 14468669 | |
| the phage receptors of bacillus anthracis. | 1961 | 14462234 | |
| [antibacterial effect of some n-substituted pyridine derivatives. i]. | 1962 | 14458073 | |
| immunological studies of anthrox. ii. levels of immunity against bacillus anthracis obtained with protective antigen and live vaccine. | 1962 | 14456743 | |
| anthrax of the eyelid. | 1960 | 14446872 | |
| control of anthrax. suggestions based on survey of imported hides. | 1959 | 14444846 | |
| the serological relationship between purified preparations of factors i and ii of the anthrax toxin produced in vivo and in vitro. | 1960 | 14441729 | |
| [apropos of the anthrax vaccine virus of pasteur, chamberland and roux]. | 1960 | 14436064 | |
| serologic testing for anthrax antibodies in workers in a goat hair processing mill. | 1960 | 14427621 | |
| cutaneous anthrax in moshi district. | 1960 | 14426882 | |
| [research on the action of erythromycin on guinea pigs inoculated with bacillus anthracis]. | 1960 | 14418101 | |
| homogeneity of response of mouse and guinea pig strains to virulence tests with bacillus anthracis and pasteurella tularensis. | 1959 | 14417035 | |
| comparative study of the agglutinogens of the endospores of bacillus anthracis and bacillus cereus. | 1960 | 14413545 | |
| a history of anthrax. | 1959 | 14409786 | |
| [vaccination against anthrax infection by killed bacilli in oil excipient]. | 1960 | 14406453 | |
| [on the criteria for usefulness and methods for the control of anthrax vaccine sti]. | 1959 | 14406135 | |
| [determination of viability of spores in anthrax sti vaccine with the aid of microcultures]. | 1959 | 14406134 | |
| the earliest account of anthrax in man and animals in north america. | 1959 | 14399630 | |
| the isolation of bacillus anthracis from bones. | 1955 | 14392938 | |
| comparative study of host resistance of guinea pigs and rats. i. virulence of diplococcus pneumoniae and bacillus anthracis for guinea pigs and rats. | 1955 | 14392367 | |
| [preparation of anthrax vaccine from non-pathogenic strains of bacillus anthracis]. | 1954 | 14391989 | |
| [not available]. | 1955 | 14390823 | |
| electric energy as a lethal lytic and antigen-extractive agent for bacterial cell. ii. the antigen-extractive action, with special reference to the possibility of differentiating the vegetative and the spore antigens in bacillus anthracis. | 1953 | 14382306 | |
| the induction of motility in bacillus anthracis by means of bacteriophage lysates: significance for the relationship of bacillus anthracis to bacillus cereus. | 1955 | 14381382 | |
| influence of oxygen uptake and age of culture on sporulation of bacillus anthracis and bacillus globigii. | 1955 | 14367301 | |
| the effect of certain enzyme systems on the capsule of bacillus anthracis. | 1955 | 14367289 | |
| a clinical note on an outbreak of cutaneous anthrax in the lundi native reserve. | 1955 | 14364574 | |
| [bacillus anthracis life cycle in a sporogenesis-inhibiting terrain]. | 1954 | 14363408 | |
| germicidal effectiveness of formaldehyde fixatives and preservatives against bacillus anthracis in animal tissue. | 1955 | 14361428 | |
| [two cases of anthrax infection with pharyngeal localization]. | 1954 | 14357856 | |
| anthrax and bone-meal fertiliser. | 1955 | 14354933 | |
| specific identification of bacillus anthracis by means of a variant bacteriophage. | 1955 | 14354236 | |
| [case of symptomatic anthrax in a dog]. | 1954 | 14350353 | |
| [some epidemiologic observations on cases of anthrax, treated at the clinic of infectious diseases of the lublin medical academy]. | 1965 | 14347476 | |
| [some data on therapeutic properties of d-17 mycetin]. | 1964 | 14347062 | |
| use of fluorescent antibodies for the rapid diagnosis of infections caused by b. anthracis and p. tularensis. | 1965 | 14345660 | |
| some diseases common to animals and man. | 1965 | 14337624 | |
| [effect of various alcohols on the cytoplasm of a bacillus specie]. | 1965 | 14334407 | |
| anthrax and antibiotics. | 1965 | 14331476 | |
| the chemistry of the cell walls of bacillus anthracis: the effect of penicillin. | 1965 | 14329285 | |
| inducible lytic systems in the genus bacillus. | 1965 | 14328413 | |
| anthrax in bison in the northwest territories. | 1965 | 14323057 | |
| alkaline phosphatase repression by inorganic phosphate in bacillus anthracis and bacillus cereus. | 1964 | 14314671 | |
| [further data on the pathogenesis of anthrax infection and anti-anthrax immunity]. | 1964 | 14312709 | |
| [antigenic structure of the vaccinal strain of bac. anthracis]. | 1964 | 14295826 | |
| [study of immunogenesis following vaccination with live associated vaccine. i. study of immunogenesis in guinea pigs, vaccinated with brucella and anthrax vaccine]. | 1964 | 14295816 | |
| [studies on capsular anthrax sera and methods for the determination of their immunological activity]. | 1964 | 14295010 | |
| successful treatment of rhesus monkeys for septicemia anthrax. | 1964 | 14288031 | |
| the incidence and epidemiology of disease in kenya. i. some diseases of social significance. | 1965 | 14286359 | |
| [on the stability of the bological properties of the anthrax sti-1 vaccine strain]. | 1964 | 14279452 | |
| formation of spheroplasts from bacillus anthracis. | chatterjee, b. r. (baylor university college of medicine, houston, tex.), and robert p. williams. formation of spheroplasts from bacillus anthracis. j. bacteriol. 89:1128-1133. 1965.-spheroplasts were prepared from bacillus anthracis by combined treatment with lysozyme and glycine. glycine, at a final concentration of 3%, was added to cultures of b. anthracis in nutrient broth that had grown at 37 c for 16 to 18 hr under 50% co(2). after additional incubation under co(2) for 2 hr, lysozyme, at t ... | 1965 | 14276107 |
| anthracidins a and b, new antibiotics. | 1963 | 14274977 | |
| plate micromethods for the detection of indole produced by bacteria. | 1964 | 14270089 | |
| plate micromethods for the determination of urea decomposition by bacteria. | 1964 | 14270088 | |
| [cytological and cytochemical study of the capsule and cell wall of bacillus anthracis]. | 1964 | 14267392 | |
| [studies on phagocytosis in animals with high and low bactericidal properties of the blood]. | 1964 | 14266468 | |
| [apropos of antibacterial properties of intravascular and in vitro blood]. | 1964 | 14266467 | |
| studies on anthrax infections in immunized guinea pigs. | 1965 | 14258478 | |
| [further experimental study of the efficacy of chemical anthrax vaccine]. | 1964 | 14255898 | |
| effect of hematin on the recovery of bacillus anthracis and related organisms. | 1965 | 14255729 | |
| quantitative assay for crude anthrax toxins. | haines, bertram w. (u.s. army biological laboratories, frederick, md.), frederick klein, and ralph e. lincoln. quantitative assay for crude anthrax toxins. j. bacteriol. 89:74-83. 1965.-the whole crude toxins of bacillus anthracis, although apparently responsible for the death of animals with anthrax, had never been quantitated. a total of 14 lots of the toxic culture filtrate of b. anthracis were pooled into one large lot of crude anthrax toxins. an extensive assay of this reference material wa ... | 1965 | 14255684 |
| effect of egg yolk and phosphatides on anthrax infection of rats and guinea pigs. | 1965 | 14254517 | |
| [aspects of parasitic and infectious tropical pathology in the republic of haiti]. | 1964 | 14250536 | |
| [anthrax in the tirnovo district in 1958-1962]. | 1964 | 14247061 |