Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| plasmodium berghei: relationship between mitosis and erythropoiesis in spleen cells of infected rats. | 1977 | 598448 | |
| accelerated clearance of uninfected red cells from plasmodium berghei-infected mouse blood in normal mice. | 51cr-labelled uninfected cells, separated from plasmodium berghei-infected mouse blood using the fluorescence-activated cell sorter, were cleared more rapidly than normal mouse erythrocytes after intravenous injection into normal mice. | 1979 | 548017 |
| influence of malaria infection on the elaboration of soluble mediators by adherent mononuclear cells. | malaria results in two seemingly paradoxical perturbations of the immune response: polyclonal b-cell activation and immunosuppression. to determine what immunoregulatory role mediators secreted by adherent cells might play in these alterations, we cultured adherent cells from uninfected mice and from mice at different times during infection with plasmodium berghei or p. yoelii. culture supernatants obtained from these cells were tested for their ability to enhance the in vitro proliferative resp ... | 1979 | 457269 |
| immune phagocytosis in murine malaria. | spleen macrophages from plasmodium berghei-infected mice are more efficient in the ingestion of parasitized reticulocytes than spleen macrophages obtained from normal animals. other indications of spleen macrophage activation detected during malarial infection are enhanced macrophage spreading and increased phagocytosis of opsonized and nonopsonized sheep erythrocytes (e). peritoneal macrophages are not activated to a significant degree. the appearance of antibodies directed against forssman ant ... | 1979 | 448288 |
| the significance of plasma kinins in malaria. | 1978 | 416663 | |
| [light microscopic and scanning electron microscopic observations on phagocytosis of plasmodium berghei infected erythrocytes by mouse macrophages [author's transl)]. | peritoneal macrophages from mice were cultured in leighton tubes for 2 hours. thereafter suspensions of washed red blood corpuscles originating from plasmodium berghei-infected mice were offered to the cultured cells for phagocytosis. after 15 minutes of incubation 13,5% of the macrophages showed phagocytized parasites if the peritoneal cells came from malariaimmune mice. cells from normal mice or from infected mice had lower rates (4,8/9,1%). after an incubation of 3 hours about 50% of the cell ... | 1977 | 414386 |
| exacerbation of experimental trypanosoma cruzi infection in mice by concomitant malaria. | the effect of malaria on the chronic phase of chagas' disease was investigated in mice. the animals were given plasmodium bergheri-infected red blood cells 2 to 12 months after their initial inoculation with trypomastigotes of 3 different strains of trypanosoma cruzi (y. cl and gilmar). in all the experiments carried out with one of the strains (cl), a somewhat variable but always considerable percentage of mice (average 39%) relapsed in to the acute phase of chagas' disease. this relapse was ch ... | 1977 | 413912 |
| modifications of primiaquine as antimalarials. 2. 5-phenylthio and 5-anilino derivatives of primaquine. | a number of 5-phenylthio and 5-anilino derivatives of primaquine have been prepared which are less toxic but less active than primaquine itself in murine and monkey antimalarial screens. it is apparent that the toxicity of primaquine can be diminished by introduction at position 5 of phenylthio, anilino, or phenoxy groups. however, the best hope for concomitant retention of high activity would seem to reside with the phenoxy moieties. | 1978 | 412967 |
| antimalarials. 10. synthesis of 4-substituted primaquine analogues as candidate antimalarials. | primaquine (i) has been extensively used in combination with other drugs in the radical cure of relapsing malaria as well as for prophylaxis or the interruption of transmission. this, coupled with the activity data reported for 4-methylprimaquine (ii), has led to the synthesis of a series of 14 4-substituted analogues of i. in addition, three side-chain analogues of ii were prepared. the compounds were tested for suppressive antimalarial activity against plasmodium berghei in the rane mouse scre ... | 1977 | 411930 |
| synthesis of 2-benzyloxy and 2-benzylthio analogues of primaquine as potential antimalarials. | a series of 2-benzyloxy and 2-benzylthio analogues of primaquine has been synthesized and evaluated against plasmodium berghei in the mouse and plasmodium cynomolgi in the rhesus monkey. 8-aminoquinoline toxicity, as measured in the rane mouse screen, was reduced, and these compounds showed significant blood schizonticidal antimalarial activity in mice. in monkeys, significant tissue-schizonticidal activity was observed. | 1977 | 409843 |
| modifications of primaquine as antimalarials. 1. 5-phenoxy derivatives of primaquine. | various 5-phenoxy derivatives of primaquine have been prepared which are more active and less toxic than the parent compound in murine and monkey antimalarial screens. an improved method for the phthalimido alkylation of amines is described. | 1977 | 408489 |
| ficoll fractionation for the separation of parasitized erythrocytes from malaria infected blood. | separation and concentration of parasitized erythrocytes from infected blood was achieved by centrifugation of a sample placed in a layer on top of a cushion of a ficoll solution with a critical density. pure suspensions of parasitized erythrocytes were obtained from plasmodium berghei infected rodent blood, whereas results with p. vivax infected monkey (aotus trivirgatus) blood were partially successful. titration experiments revealed that the parasitized erythrocytes obtained by ficoll fractio ... | 1977 | 408020 |
| electrophoresis of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in erythrocytes from malaria-infected animals. | electrophoresis of red-cell extracts from control and malaria-infected animals on 'cellogel' demonstrated the absence of g-6-pd activity of 'parasite' origin, although 6-pgd activity was present. an identical 6-pgd isoenzyme was found in mice, rats and hamsters infected with the same strain of plasmodium berghei indicating the parasite as the source of the enzyme. a similar 6-pgd isoenzyme was also found in a few preliminary experiments with p. knowlesi-infected monkey erythrocytes. the implicat ... | 1977 | 405935 |
| studies on the invasive ability of malarial merozoites (plasmodium berghei). | studies were performed to evaluate several methods for the artificial removal of plasmodium berghei merozoites from infected mouse erythrocytes. these methods, many of which have been reported to yield free parasites capable of establishing a patent infection when injected into a suitable host, included nh4c1-mediated lysis, complement-mediated immune lysis, pressure filtration, and multiple-burst and continuous-flow sonication. free parasites isolated from infected mouse blood were examined in ... | 1977 | 405468 |
| spleen-derived mononuclear cell chemotactic factor in malaria infections: a possible mechanism for splenic macrophage accumulation. | 1977 | 402418 | |
| studies on susceptibility to plasmodium berghei in a normal vector population of anopheles atroparvus after the introduction of plasmodium-refractory genotypes: the establishment of the vector population with overlapping generations. | 1979 | 400467 | |
| modulation by malaria infection of the induction of t lymphocyte-dependent delayed-type hypersensitivity and antibody formation to sheep erythrocytes in mice. | a profound alteration of the inductive phase of delayed-type hypersensitivity and antibody formation to srbc was found in malaria infected mice when sensitization with this antigen was performed intravenously at a critical time of the disease, but not after subcutaneous immunization, suggesting a major role for the spleen in the mechanism of immunodepression. | 1979 | 399338 |
| antibody responses in mice protected against malaria by vaccination. | mice were vaccinated against lethal p. yoelii or p. berghei malaria and their immunofluorescent anti-parasite antibody levels followed after infection with live homologous parasites. there was a good correlation between antibody titres (especially igg) and protection, under various experimental conditions, including: different doses of vaccine, different strains of mice, and increase or decrease of macrophage function. when antiserum was passively transferred to normal recipients, protection aga ... | 1979 | 399336 |
| immunosuppression in murine malaria. iv. the secondary response to bovine serum albumin. | the anamnestic antibody response of cba mice to bovine serum albumin was characterized by a rapid production of high-avidity antibody. after 3 weeks both the total amount of antibody and its avidity declined but still remained above those seen in the primary response for at least 6 weeks. the effects of acute plasmodium berghei and plasmodium yoelii yoelii infections upon the induction and the expression of this anamnestic response were studied. mice infected with these malaria parasites respond ... | 1979 | 399334 |
| immunoprecipitation of biosynthetically-labelled products in the identification of antigens of murine red cells infected with the protozoan parasite, plasmodium berghei. | in this methodological paper an immunoprecipitation technique has been optimised for the identification of antigens of plasmodium berghei-infected blood which react with antibody specificities in a host-protective antiserum. extracted 3h-leucine biosynthetically-labelled products of infected blood were sequentially reacted and precipitated with sera from mice which had been exposed to p. berghei but which were either non-protected or protected against lethal infection, protection having been sho ... | 1979 | 398697 |
| selection of a chloroquine resistant strain of plasmodium berghei. | 1979 | 398346 | |
| selection of a primaquine resistant strain of plasmodium berghei. | 1979 | 398345 | |
| [proposition of a cycle suggested by the morphological incidences of malaria induced by plasmodium berghei in the mouse (author's transl)]. | 1979 | 398178 | |
| genetic modification of macrophage functions in relation to antibody responsiveness and resistance to infection. | 1979 | 397751 | |
| soluble antigens released in vitro from erythrocytes infected with plasmodium berghei. | rat erythrocytes parasitized with plasmodium berghei were found to release soluble antigenic products in vitro. the supernatants obtained by centrifugation of the disrupted cells induced specific transformation of non-adherent spleen lymphocytes of convalescent rats and produced precipitation lines with antiplasmodial antibodies. in a preliminary experiment they also immunized young rats against a viable challenge of p. berghei. it is suggested that the soluble material could serve for the purif ... | 1979 | 397011 |
| [synthesis of quinolines with heterocyclic substituents at position 3 (author's transl)]. | 1979 | 396909 | |
| [observations on the virulence and the antigenic characters of cloned and uncloned lines of the anka isolate of plasmodium berghei. 2. cross-protection assay with successive recrudescent populations]. | 1979 | 396896 | |
| [observations on the virulence and the antigenic characters of cloned and uncloned lines of the anka isolate of plasmodium berghei. 1. production of recrudescent parasitaemias in immunized mice]. | 1979 | 396895 | |
| nutritional studies of the south east peasant diet: studies on the effect of malarial infection (plasmodium berghei) on serum protein and trace element concentrations in rats offered a peasants' diet. | 1979 | 396732 | |
| pathology of anopheles stephensi after infection with plasmodium berghei berghei. ii. changes in amino acid contents. | infection with plasmodium berghei results in the disease of a relatively high percentage of mosquitoes depending on the experimental conditions. the damage caused by the parasites may be so severe that the host dies. it can also become manifest for instance in a change in the amino acid content of the mosquito homogenate. the amino acid content of mosquitoes fed on a glucose solution, normal mouse blood, or the blood of infected mice was analysed qualitatively and quantitatively over a period of ... | 1979 | 396730 |
| pathology of anopheles stephensi after infection with plasmodium berghei berghei. i. mortality rate. | the mortality of p. berghei-infected anopheles stephensi females can be about 30% higher during the first three days than in normal blood-fed mosquitoes. as expected the mortality is higher after feeding on highly infected mice but also depends on the date of feeding and the temperature. infected mosquitoes kept at 25 degrees c die more often than those kept at 21 degrees c. on the other hand sporozoite production needs the low temperature of 21 degrees c. so the sporozoite production rate falls ... | 1979 | 396729 |
| antimalarial activity of the optical isomers of chloroquine diphosphate. | optically pure d- and l-chloroquine diphosphate were examined for their efficacy against plasmodium berghei in mice. the d-enantiomer is significantly more effective than the corresponding l-enantiomer, and in subcurative doses the d-enantiomer is also signficantly more active than the racemate. this increased activity has however no influence upon chloroquine-resistant strains of p. berghei. the ld50 in non-infected mice is higher for the d-enantiomer than for either the racemate or the l-enan ... | 1979 | 396700 |
| [myelin-like forms of erythrocytes, monocytes (macrophages) and neutrophilic granulocytes in mice infested with plasmodium berghei (author's transl)]. | 1979 | 395875 | |
| exoerythrocytic merozoites of plasmodium berghei in rat hepatic kupffer cells. | liver biopsies of white rates infected by plasmodium berghei sporozoites were examined by electron microscopy. intrahepatocytic schizont development was confirmed. in addition, at 60 and 70 h after sporozoite inoculation, exoerythrocytic merozoites were noted in kupffer cells of liver sinusoids. although it is theoretically possible that this observation may be of merozoite development in kupffer cells, the authors suspect that this example of phagocytosis would be one of the host's natural defe ... | 1979 | 395294 |
| hemolymph volume of noninfected and plasmodium berghei-infected anopheles stephensi. | 1979 | 395256 | |
| [synthesis of m6407, a new anti-malarial agent (author's transl)]. | 1979 | 394574 | |
| antisporozoite antibodies in mice immunized with irradiation-attenuated plasmodium berghei sporozoites. | sera from nmri/nih mice were tested for the presence of igm and igg anti-sporozoite antibodies using the indirect fluorescent antibody test (ifat). both igm and igg antibody titres were related to the number of immunizations with irradition-attenuated plasmodium berghei sporozoites, and protection from challenge with subsequent non-attenuated sporozoites correlated with the pre-challenge antibody titre. sera taken five days following challenge showed marked reductions in antibody titres, except ... | 1979 | 394412 |
| the cultivation of the exoerythrocytic stages of plasmodium berghei from sporozoites. | 1979 | 393619 | |
| 2-acetylpyridine thiosemicarbazones. 2. n4,n4-disubstituted derivatives as potential antimalarial agents. | the most effective antimalarial agents among the n4-monosubstituted 2-acetylpyridine thiosemicarbazones recently described by us have a cyclohexyl or a phenyl substituent and produce cures in plasmodium berghei infected mice at a dose of 160 and 320 mg/kg, respectively. we report here on a related series of n4,n4-disubstituted 2-acetylpyridine thiosemicarbazones. several members of this group bearing alkyl or cycloalkyl substituents at n4 show activity superior to the most active monosubstituted ... | 1979 | 392099 |
| mean cytoplasmic protein concentration of host erythrocytes and the reticulocyte response in plasmodium berghei infected mice. | the decreasing mean cytoplasmic protein concentration (mpc) of p. berghei host cells is paralled by an increasing parasitemia and percent reticulocyte response. the reticulocyte response parallels the percent parasitemia except during a period of accelerated reticulocytosis noted during the midpoint of the infection at which time the percent reticulocytes increases at a rate more than double the rate of increase of percent parasitemia. although the reticulocyte population and the host cell popul ... | 1979 | 391584 |
| [the infectivity of plasmodium berghei sporozoites during laboratory manipulation]. | 1979 | 391163 | |
| altered erythropoiesis during the course of virulent murine malaria. | 1979 | 390536 | |
| cell-mediated immunity in the liver of mice vaccinated against malaria. | mice can be protected against several species of lethal malaria infection by vaccination, and their recovery correlates well with increased anti-malarial antibody levels, particularly igg (ref.2). however, there is also a good correlation between protection by vaccines and priming for delayed-type hypersensitivity in the skin, although there is no obvious explanation for this effect. we now report an apparent relationship between protection and a cell-mediated immune response involving the migra ... | 1979 | 390399 |
| [synthesis of 1-(3-quinolino)-2-alkylaminoethanols (author's transl)]. | 1979 | 389197 | |
| different appearance of parasitized erythrocytes in blood between normal and toxoplasma-infected rats after infection of plasmodium berghei. | when normal rats were infected with plasmodium berghei (pb), both igg and igm immunofluorescent antibody titers were found to rise in the 1st week with increase of parasitaemia. after reinoculation of p. berghei into pb-immune rats, igg titer was further increased remarkably, although no parasitaemia was observed. no elevation of igm titer was found. in rats infected with toxoplasma gondii (tg), igg and igm antibody activities were demonstrated in the 1st to the 3rd week postinfection but only i ... | 1979 | 388945 |
| serum opsonic activity in rodent malaria: functional and immunochemical characteristics in vitro. | the functional and immunochemical characteristics of serum opsonic activity in rodent malaria were examined in the present study. schizont- and late trophozoite-enriched populations of plasmodium berghei-infected red blood cells (irbc) were isolated on a ficoll density-gradient and used in an in vitro phagocytosis system composed of serum and monolayer cultures of rat peritoneal macrophages. hyperimmune serum augmented the phagocytosis of irbc to a greater degree than did nonimmune serum. when e ... | 1979 | 387873 |
| lipid composition and activity of a lytic factor isolated from plasmodium berghei. | a fraction was obtained from plasmodium berghei which induced hemolysis of the erythrocytes of mice and hamsters. this fraction, called lytic factor (lf), was found to be composed of a large amount of lipid material. an examination of the lipids showed the major lipids to be monoglycerides, diglycerides, triglycerides, fatty acids, long-chain alcohol, sterol, sterol ester, sterol glycoside, and two cerebrosides. the most abundant component found in the lf was sterol ester, followed in order by c ... | 1979 | 387594 |
| urea and electrolyte studies in albino rats in plasmodium berghei infection. | 1979 | 387582 | |
| biochemistry of intraerythrocytic parasites. ii. comparative studies in carbohydrate metabolism. | comparative studies were carried out on the glucose catabolism of mouse erythrocytes infected with plasmodium berghei, plasmodium yoelii, babesia rodhaini, babesia microti and anthemosoma garnhami, as well as on uninfected erythrocytes and reticulocytes. the results showed that there was little qualitative difference between the glucose utilization and lactate production of the parasites although quantitative differences between malaria parasites and piroplasms were observed. the rate of glucose ... | 1979 | 386968 |
| biochemistry of intraerythrocytic parasites. i. identification of enzymes of parasite origin by starch-gel electrophoresis. | enzymes of parasite origin were identified by starch-gel electrophoresis. the species of parasite studied were plasmodium berghei, plasmodium yoelii nigeriensis, babesia rodhaini and anthemosoma garnhami. lactate dehydrogenase, glucose phosphate isomerase and (nadp) glutamate dehydrogenase were detected in all species; phosphogluconate dehydrogenase was detected in both plasmodium species but malate dehydrogenase only in p. y. nigeriensis. glucose-6-phosphate dehydrogenase, alanine aminotransfer ... | 1979 | 386967 |
| experimental studies on the effect of proguanil and dapsone against chloroquine-resistant plasmodium berghei (anka) in white mice. | 1979 | 386963 | |
| freeze-fracture study of malaria sporozoites: antibody-induced changes of the pellicular membrane. | plasmodium cynomolgi, plasmodium knowlesi, and plasmodium berghei sporozoites, before and after incubation with immune serum, were studied after freeze-fracture by electron microscopy. there were evenly distributed numerous intramembranous particles (imp) on the p face of the outer membrane. the e face of the plasma membrane had fewer imp than its p face. the e face of the intermediate membrane had few imp and also linear arrays of slightly raised ridges running the length of the parasite. the p ... | 1979 | 385856 |
| mechanisms of action of hyperimmune serum in mediating protective immunity to rodent malaria (plasmodium berghei). | 1979 | 385778 | |
| plasmodium berghei--infected mice. focal glomerulonephritis in hyperimmune state. | twenty-one male swiss albino mice were injected intraperitoneally with 2 x 10(5) plasmodium berghei berghei-infected cells. twenty-four mice were used as a noninfected control group. on the tenth day after infection, three mice were killed and the remainder were treated with chloroquine phosphate (0.025% solution) given orally. the dosage was subsequently adjusted to keep the parasitemia below 5%. eighteen of the controls received the same chloroquine dosage. diffuse proliferative glomerulonephr ... | 1979 | 384958 |
| [production of interferon after infection by various doses of "plasmodium berghei" in mice (author's transl)]. | groups of mice were inoculated with either low or high intraperitoneal doses of plasmodium berghei infected erythrocytes (pie). the course of infection was observed daily by counting new pie which appeared in the red blood cells (rbc) of infected mice. at the same time, circulating interferon (if) was tested. when low doses of infecting pie were used (400 per mouse), circulating if was first detected on the 5th day after inoculation. it increased to a maximal rate, when 5% of rbc were affected. ... | 1979 | 384870 |
| [malaria plasmodia in the mouse. parasitization of mature and immature erythrocytes by plasmodium berghei, plasmodium yoelii and plasmodium chabaudi (author's transl)]. | plasmodium berghei parasites (strain k173) in mice with developing immunity changed to a variant type with increased resistance against antibodies and enhanced invasion of mature erythrocytes; on passages in normal mice this variant type retransformed to the normal type (kretschmar 1964). on detailed study, parasites of the variant type showed a markedly decreased predilection for polychromatophilic erythrocytes, leading to slowed multiplication during prepatency, increased invasion of mature er ... | 1979 | 384629 |
| [serodiagnosis of malaria. plasmodium berghei and p. falciparum as antigen for the indirect immune of fluorescence test (author's transl)]. | serum samples of malaria patients were investigated by the iift with p. berghei antigen (from mice) and p. falciparum antigen (from in vitro cultures). both antigens were useful principally and produced approximately identical results. p. falciparum antigen produced mostly higher titres than p. berghei antigen. in cases of lack of homologous malaria antigen it can be suitable to use an antibody-free p. berghei antigen for the iift, especially in cases of epidemiological studies. for the individu ... | 1979 | 383607 |
| plasmodium berghei: uptake of clindamycin and its metabolites by mouse erythrocytes with clindamycin-sensitive and clindamycin-resistant parasites. | 1979 | 383487 | |
| liposomes in the chemotherapy of experimental murine malaria. | 1979 | 382476 | |
| sporozoite-induced malaria: therapeutic effects of glycolipids in liposomes. | liposomes containing neutral glycolipids with a terminal glucose or galactose, when injected intravenously, prevented the appearance of erythrocytic forms of malaria (plasmodium berghei) in mice previously injected with sporozoites. inhibitory glycolipids included glucosyl, galactosyl, or lactosyl ceramide. inhibition was not observed with liposomes containing ceramide, phosphocholine ceramide, sulfogalactosyl ceramide (sulfatide), or ganglioside gm1. liposomes containing glycolipids did not inh ... | 1979 | 382358 |
| immunopathological studies of plasmodium berghei infected mice: (effect of carbon particles). | an attempt was made to block the role of the macrophages in the immune response by saturating them with carbon particles. the experiment was performed on swiss albino female mice injected intraperitoneally with 10(5) p. berghei berghei. these mice were injected with carbon particles of 20 mgs on the day before the inoculation and again 10 mgs on day 4 and day 9 after the inoculation. the degree of parasitaemia was slightly higher throughout the experiment in the infected mice treated with carbon ... | 1979 | 381681 |
| electron microscopy of cerebral malaria in golden hamsters (mesocricetus auratus) infected with plasmodium berghei. | transmission and scanning electron microscopy of hamster cerebral malaria show that haemorrhages occur following vessel necrosis in animals with low parasitaemias. there is no concurrent thrombosis nor packing of capillaries with parasitised erythrocytes. small vessels contain numerous monocytes which have phagocytosed erythrocytes and smaller particles of similar electron density. the monocytes attach to and migrate through the endothelium but then remain in close proximity to the vessels. irre ... | 1979 | 381611 |
| host defenses in murine malaria: analysis of the mechanisms of immunity to plasmodium berghei generated in response to immunization with formalin-killed blood-stage parasites. | syngeneic b6d2f1 (c57bl/6 x dba/2) mice were immunized with a nonliving antigen prepared from mixed blood forms of plasmodium berghei strain nyu-2. consistently greater than 80% of the vaccinated mice survived virulent challenge, and protective immunity was demonstrable from 1 week through at least 4 months after immunization. however, vaccination did not prevent the development of patient infection after challenge. instead, infections in vaccinated mice progressed to about 10% parasitemia and w ... | 1979 | 381198 |
| alterations in some biochemical parameters in mouse liver and spleen during infection with plasmodium berghei. | 1979 | 381192 | |
| dissociative effects of malarial infection on humoral and cell-mediated immunity in mice. | the effect of malarial infection on immune responses was studied in mice. when sheep red blood cells (srbc) were injected 2 days before or at the same time as infection with plasmodium berghei, there was a marked increase in the number of splenic plaque forming cells (pfc) induced by srbc as compared with uninfected controls. when srbc were injected 2 days or more after the infection, however, the pfc response was significantly reduced. on the other hand, cell-mediated immunity, as exemplified b ... | 1979 | 381176 |
| nutritional studies of the south eastern state peasant diet: studies of the effect of malarial infection (plasmodium berghei) on electrolyte changes in rats fed the peasants' diet. | 1. plasmodium berghei (malaria infection) is not specifically related to the nutritional status of the host though nutritional status may aid the advance or elimination of the parasite. 2. the effect of the infection is more severe in low protein diets than in diets whose protein content was adequate. 3. there was no evidence of excessive urinary excretion of electrolytes in the infected rats. 4. it is suggested that low plasma levels of electrolytes in the infected rats were due to skin losses ... | 1978 | 380218 |
| selection of pyrimethamine resistant strain of plasmodium berghei. | 1979 | 378824 | |
| phosphorylation of membrane proteins from plasmodium berghei-infected red cells. | 1979 | 378225 | |
| spleen plays major role in removal from bloodstream of malaria-infected rbcs. | 1979 | 377364 | |
| immunosuppression induced by plasmodium berghei and p. chabaudi infections in mice. | 1978 | 377186 | |
| dipeptides of o-methyl-l-threonine as potential antimalarials. | l-leucyl-o-methyl-l-threonine, o-methyl-l-threonyl-l-leucine, and o-methyl-l-threonyl-o-methyl-l-threonine were prepared and compared with o-methyl-l-threonine and l-leucine for antimalarial activity against plasmodium berghei in mice. o-methyl-l-threonine significantly prolonged survival time at doses of 160, 320, and 640 mg/kg. o-methyl-l-threonyl-o-methyl-l-threonine was less active, significantly prolonging survival time only at 640 mg/kg. l-leucine, as well as the other two dipeptides, exhi ... | 1979 | 376849 |
| 2-acetylpyridine thiosemicarbazones. 1. a new class of potential antimalarial agents. | based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against plasmodium berghei in mice. screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at n4 of the thiosemicarbazone moiety also contribute to antimalarial activity. | 1979 | 376848 |
| isolation of plasmodium berghei by hemolysin lysis of infected erythrocytes and evidence for a parasite hexokinase. | a rapid and simple procedure has been developed for the isolation of plasmodium berghei parasites from infected-mouse erythrocytes employing the heat stable hemolysin produced by pseudomonas aeruginosa. using parasites isolated by this method, the presence of a parasite specific hexokinase has been demonstrated, providing an explanation for the increased glucose consumption observed with infected cells. enzyme assays and serology were employed in determining the purity and yield of purified para ... | 1979 | 376819 |
| hemolymph of anopheles stephensi from noninfected and plasmodium berghei-infected mosquitoes. 3. carbohydrates. | determinations were made of carbohydrates in hemolymph collected from adult female mosquitoes (anopheles stephensi). first the hemolymph was fractionated by extraction and precipitation procedures, after which qualitative and quantitative determinations of carbohydrates were made by thin layer chromatography. the most abundant sugars found in the hemolymph were glucose and trehalose, though maltose, glucuronic acid, and inositol could be found after the mosquitoes took blood meals. after the mos ... | 1979 | 376818 |
| hemolymph of anopheles stephensi from uninfected and plasmodium berghei-infected mosquitoes. 2. free amino acids. | determinations were made of free amino acids in hemolymph collected from adult female anopheles stephensi mosquitoes. the hemolymph first was fractionated by extraction and precipitation procedures, after which qualitative determinations of free amino acids were made by high voltage thin layer electrophoresis, and thin layer chromatography. subsequent quantitative determinations were made with an automatic amino acid analyzer. the concentration of total free amino acids in the hemolymph rose 60- ... | 1979 | 376812 |
| circulating and tissue-bound immune complex formation in murine malaria. | immune complex formation during plasmodium berghei infection of of1 mice was investigated. circulating immune complexes (cic) were detected by the clg-binding assay and the conglutinin-binding solid-phase assay in lethal or drug-limited infections. cic appeared on day 9 of infection, peaked on day 11, and disappeared only after complete cure of the infection. analysis of the immune complexes detected by the clq-binding assay revealed the following characteristics: sedimentation coefficients of 1 ... | 1979 | 376733 |
| intravascular clearance of parasitized erythrocytes in rodent malaria. | little is known about host defense mechanisms responsible for protective immunity in malaria. the intravascular location of the infection suggested that removal of parasitized erythrocytes by reticuloendothelial organs might be important. to study this possibility, we examined the clearance of (51)crlabeled plasmodium berghei-infected erythrocytes in rats. infected erythrocytes were removed more rapidly from circulation than homologous uninfected erythrocytes. the rate of clearance of infected c ... | 1979 | 376554 |
| plasmodium berghei: effect of antithymocyte serum on induction of immunity in the mouse. | 1979 | 376327 | |
| protection of mice against plasmodium and babesia infections: attempts to raise host-protective sera. | in an attempt to generate large numbers of mice resistant to plasmodium berghei and babesia rodhaini to be used as donors of antibody-secreting cells for hybridoma production, various methods of inducing resistance to repeated challenge with infected blood cells have been explored. although results of independent experiments varied markedly, prior injection of cba/m mice with bcg, and prior infection of balb/c mice with plasmodium yoelii, were found to be manipulations capable of inducing resist ... | 1978 | 375903 |
| [further observations of the course of plasmodium berghei infection in the mouse]. | invasion of immature and mature erythrocytes by merozoites of plasmodium berghei seems to obey the following rules: merozoites prefer unparasitized immature erythrocytes. multiple infections of immature erythrocytes occur in conditions of high merozoite production and low concentration of unparasitized immature erythrocytes, when frequently repeated contacts between merozoites and unparasitized or freshly parasitized immature erythrocytes become increasingly probable. mature erythrocytes are inv ... | 1979 | 375509 |
| phenazines with two cationic side chains as potential antimalarials. | 1,9-phenazine-bis(dialkylaminocarboxamides) were prepared for screening as potential antimalarials. no significant activity against plasmodium berghei was observed. the phenazine targets were prepared from 1,9-phenazinedicarboxylic acid by standard methods. the reaction between 1,9-phenazinedicarboxylic acid and thionyl chloride in the presence of dimethylformamide unexpectedly gave 4-chloro-1,9-phenazinedicarbonyl chloride. | 1979 | 374708 |
| immunosuppression in murine malaria. iii. induction of tolerance and of immunological memory by soluble bovine serum albumin. | the primary antibody response to alumadsorbed bsa was depressed when initiated during low-grade chronic plasmodium berghei malaria in mice, as previously reported during acute p.y. yoelii infection. induction of immunological memory by soluble polymerized bsa was abolished in both infections; in infected hosts this normally immunogenic stimulus resulted in partial tolerance. in contrast to the depression of immune response, neither infection interfered with the induction of low-zone tolerance by ... | 1979 | 374257 |
| experimental studies of schistosomal pigment from schistosoma japonicum. | the schistosomal and malarial pigments were distinguishable before and after extraction from the host liver. presence of iron in both pigments was ascertained by the elemental x-ray analysis. histochemically, however, schistosomal pigment was similar to that of malarial pigment. | 1979 | 374107 |
| plasmodium berghei: correlation of in vitro erythrophagocytosis with the dynamics of early-onset anemia and reticulocytosis in mice. | 1979 | 374106 | |
| host defenses in murine malaria: successful vaccination of mice against plasmodium berghei by using formolized blood parasites. | infections of normal icr mice with the nyu-2 strain of plasmodium berghei (pb) are uniformly fatal. however, a proportion of mice that have been vaccinated with a formalin-killed antigen prepared from the blood stages of pb survive an otherwise lethal challenge. such immunity is not induced by immunization with normal mouse erythrocytes. the level of acquired anti-malarial immunity is related to the size and number of doses of antigen, and intravenous injection is superior to the subcutaneous ro ... | 1979 | 373471 |
| effect of temperature and clofibrate on plasmodium berghei infection in mice. | parasitemia counts established that 22 degrees c-acclimated mice subjected to cold exposure for a short time (-35 degrees c for 30 min) during plasmodium berghei infection had significantly higher parasitemia levels than parasitized mice continuously housed at 22 degrees c. parasitized 5 degrees c-acclimated mice also demonstrated higher parasitemia levels than parasitized 22 degrees c-acclimated mice. there was no correlation between plasma free fatty acid (pffa) concentration and parasitemia i ... | 1979 | 373470 |
| the ribosomes of plasmodium berghei: isolation and ribosomal ribonucleic acid analysis. | ribosomes and high molecular weight ribosomal ribonucleic acid (rrna) from the blood stages of plasmodium berghei parasites were studied in preparations free from host ribosome contamination. purified malarial ribosomes were isolated in high yield from a population of ultrastructurally intact, viable parasites by hypertonic lysis with triton x-100 and differential centrifugation. these ribosomes were shown to be derived from active polysomes and could be dissociated into subunits by puromycin-0. ... | 1978 | 372893 |
| quantitative structure-activity relationships in 1-aryl-2-(alkylamino)ethanol antimalarials. | a quantitative structure-activity relationship has been formulated for 646 antimalarials acting against p. berghei in mice. the equation developed has 14 terms, 9 of which are indicator variables. the correlation coefficient for the qsar is 0.898 and the standard deviation is 0.309. the antimalarials are all arylcarbinols of the type x-archohch2nr1r2. sixty different aryl structures, including a variety of heterocyles, are contained in the study. the most important determinate of activity is fou ... | 1979 | 372527 |
| separation of plasmodium berghei-parasitized rat erythrocytes by means of carrier-free electrophoresis. | a carrier-free electrophoresis apparatus was used to isolate rat erythrocytes parasitized with plasmodium berghei. the region of high electrophoretic mobility yielded noninfected erythrocytes, whereas that of low electrophoretic mobility yielded erythrocytes infected with viable parasites. over 98% purity of parasitized erythrocytes was obtained when blood at an advanced stage of parasitaemia was used. merozoite-rich fractions were also observed. this continuous one-step separation method should ... | 1979 | 371849 |
| the role of platelets in infections. i. observations in human and murine malaria. | the interaction between platelets and microorganisms may be underestimated. our in vivo studies support a direct role of thrombocytes in malarial infections. we have found intrathrombocytic parasites of plasmodium vivax (in 10% of men naturally infected) and p berghei (in 53% of mice experimentally infected); these were both merozoites and trophozoites. neither the mechanism of parasitization (whether by active penetration or by phagocytosis) nor the outcome of this phenomenon is known. however, ... | 1979 | 371580 |
| chloroquine resistance in malaria: accessibility of drug receptors to mefloquine. | the process of mefloquine accumulation was studied in mouse erythrocytes infected with either plasmodium berghei cs (chloroquine susceptible) or p. berghei cr (chloroquine resistant). in both cases, mefloquine was accumulated by a saturable process with an apparent dissociation constant of 2.5 x 10(-6) m and an apparent maximal capacity of 700 mumol per kg of erythrocyte pellet; uninfected mouse erythrocytes accumulated more than half as much mefloquine as infected erythrocytes. the process of a ... | 1979 | 371544 |
| antimalarials. 4. trichloronaphthalene amino alcohols. | an improved procedure for the synthesis of naphthalene amino alcohols is described. four new compounds were prepared and tested by rane laboratories for activity vs. plasmodium berghei in mice. all compounds were active, the most active being 1-[3-(4-chlorophenyl)-5,7-dichloro-1-naphthyl]-3-(di-n-butylamino)propanol hydrochloride (16b). structure--activity relationships between the naphthalene and quinoline isosteres are discussed. | 1979 | 370389 |
| changes in serum, liver, fat pad and thymus lipid levels in adult rats infected with plasmodium berghei. | 1977 | 370086 | |
| [in vivo formation of myelin-like forms in mouse erythrocytes infested by plasmodium berghei (author's transl)]. | 1978 | 369437 | |
| labelling of plasmodium berghei during sporogony. | 1977 | 369268 | |
| a susceptible and refractive strain of anopheles atroparvus van thiel to infection with plasmodium berghei berghei. | 1977 | 369264 | |
| [continuous axenic culture of mammalian plasmodia. i. plasmodium berghei]. | 1977 | 368933 | |
| immunofluorescent staining of exoerythrocytic schizonts of plasmodium berghei in fixed liver tissue with stage-specific immune serum. | 1978 | 368305 | |
| the protective effect of endogenous interferon in mouse malaria, as demonstrated by the use of anti-interferon globulins. | both death rate and percentage of parasitized erythrocytes in mice infected with plasmodium berghei were enhanced by injections of anti-interferon globulins. as, in the same time, parasite-induced interferon was neutralized by these globulins, it can be concluded that endogenous interferon plays an important inhibiting role during parasitic diseases, such as malaria, as it has been previously demonstrated in many virus infections. | 1978 | 367460 |
| removal of leucocytes from red cells in plasmodium berghei-infected mouse blood and purification of schizont-infected cells. | 1978 | 367300 |