Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| survival of aegyptianella pullorum, anaplasma marginale and various parasitic protozoa following prolonged storage in liquid nitrogen. | various protozoa species were examined using in vivo and in vitro methods to determine their ability to survive prolonged periods of storage in liquid nitrogen. the following protozoan species were successfully recovered after they had been cryopreserved for a period over 10 years: trypanosoma lewisi, t. cruzi, t. congolense, t. brucei, t. rhodesiense, t. gambiense, t. evansi, t. equinum, t. equiperdum, leishmania donovani, plasmodium berghei, p. praecox (relictum), babesia rodhaini and b. canis ... | 1977 | 919686 |
| reduced 8-aminoquinoline analogues as potential antimalarial agents. | the synthesis of 1-alkyl-8-(aminoalkylamino)-6-methyl1-1,2,3,4-tetrahydroquinolines, 8-(4'-amino-1'-methylbutylamino)-6-methoxy-1-methyl1-1,2-dihydroquinoline, 5-substituted 8-(4'-amino-1'-methylbutylamino)-1-methyl-1,2-dihydroquinolines, 8-alkylamino-1-(2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinolines, 1-)2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinoline, 1-(2-n,n-diethylaminoethyl)-8-(2-n,n-diethylaminoethylamino)-6-methoxy-1,2,3,4-tetrahydroquinoline, and 2-substit ... | 1976 | 824447 |
| 5-aryloxy-6-methoxy-8-aminoquinolines as potential prophylactic antimalarials. | 5-(p-anisyloxy)-6-methoxy-8-(5-isopropylaminopentylamino)quinoline was resynthesized for evaluation in the plasmodium berghei and monkey prophylactic (plasmodium cynomolgi) tests. a new primary amine, three secondary amines, and one structurally modified side-chain analog of the 5-aryloxy series were also prepared. none of these compounds showed significant antimalarial or prophylactic activity. | 1976 | 824437 |
| [increased non-specific resistance to induction of malaria by sporozoites of plasmodium berghei yoëlii in mice pretreated with a bacterial phospholipid extract]. | the injection of a bacterial phosphospholipid extract increases resistance of mice subsequently challenged with sporozoïtes of plasmodium berghei yoëlii. the pretreatment consisted of one injection of a suspension containing various amounts of phospholipid extract. it was e-fective when it shortly preceded the sporozoïtes inoculation. this resulted in total protection of a great number of animals against various amounts of sporozoïtes. there was a correlation between the dose of ebp injected and ... | 1975 | 819147 |
| effect of vitamin a and undernutrition on the susceptibility of rodents to a malarial parasite plasmodium berghei. | the ability of vitamin a deficient rats to resist infection with p. berghei was investigated. when 10 x 10(6) erythrocytes bearing the parasite/100 g body weight were given to the vitamin a protein energy undernourished rats, parasitemia developed in these animals at a faster pace than the controls. a high number (60% to 95%) of red blood cells (rbc) carrying the parasite were noticeable within 6 to 7 days after infection, at which time most animals in this group died. the pair-fed controls (pro ... | 1976 | 818347 |
| complement alterations in rodent malaria. | in the course of rodent malaria, the ability of mouse serum to release immune complexes from lymphocytes (complex-release, or cra), a complement dependent function, becomes profoundly altered. these alterations occur in parallel with changes in the serum levels of the third complement component (c3). a transitory but significant increase in cra and c3 was noticed during the first 3 days after blood-induced plasmodium berghei infection. this was followed by a progressive decrease in cra, which wa ... | 1976 | 816212 |
| antibody-induced ultrastructural changes of malarial sporozoites. | immunization with irradiated sporozoites produces a considerable degree protection against rodent, simian, and human malaria. this protection is in part antibody mediated. antibodies neutralize sporozoites (sna), i.e. abolish their infectivity, and cause, in vitro, the formation of a thread-like precipitate on the parasites (csp reaction). the present study was undertaken to characterize the ultrastructural aspects of antibody-sporozoite interaction. | 1976 | 815435 |
| the search for new antimalarial drugs. | 1975 | 813015 | |
| quinazolines as inhibitors of dihydrofolate reductase. 3. analogs of pteroic and isopteroic acids. | a series of 19 quinazoline analogs of pteroic and isopteroic acid was prepared with particular emphasis being placed upon carboxylic acid esters. each compound was evaluated as an inhibitor of the dihydrofolate reductases from rat liver as well as from streptococcus faecium. several of the more potent inhibitors were found to be inactive against l1210 leukemia in mice at low dose levels and were lethal to mice at 100 mg/kg. six compounds were also evaluated for antimalarial activity against plas ... | 1975 | 811798 |
| amino acid analogs. iii: new syntheses of monomethyl- and monophenylglutamic acids. | glutamic acid analogs containing 3- and 4-methyl and 2-, 3-, and 4-phenyl substituents were prepared. the 3- and 4-methyl- and 3- and 4-phenylglutamic acids did not inhibit plasmodium berghei and were nontoxic to the host (mice) at 640 mg/kg. the five analogs in addition to 2-methlglutamic acid were inactive against lactobacillus casei at 1000 mug/ml in a defined medium: against escherichia coli, only 2-methylglutamic acid caused 27% inhibition at 10,000 mug/ml. all six analogs failed to inhibit ... | 1975 | 811786 |
| orally-administered silver sulfadiazine: chemotherapy and toxicology in cf-1 mice; plasmodium berghei (malaria) and pseudomonas aeruginosa. | silver sulfadiazine when administered orally and subcutaneously to cf-1 mice in doses not exceeding 1,050 mg/kg proved to have minimal toxicity. no pathology or abnormal reactions were seen in cf-1 mice after receiving 1,050 mg/kg orally and subcutaneously once a day for 30 days. silver sulfadiazine in doses of 1,050 mg/kg, once a day for 5 days cured mice of plasmodium berghei even after splenectomy. parasitemia was reduced to zero in 1-3 days and antimalarial activity was not inhibited signifi ... | 1975 | 807459 |
| pyruvate kinase in malaria host-parasite interaction. | 1975 | 805379 | |
| biological screening in the u.s. army antimalarial drug development program. | the methods of testing drugs in the united states army antimalarial drug development program are described. to date over two hundred thousand compounds have been screened. for each 3,000 compounds evaluated in the primary screen, only 1 is assessed for efficacy in the final test system. of those potential antimalarials assessed in this last system, only about half are deemed worthy of preclinical toxicological evaluation. | 1975 | 804264 |
| the effects of azadiracta indica in acute plasmodium berghei malaria [proceedings]. | 1976 | 799404 | |
| [synthesis of quinoline-3- and quinoxaline-2- derivatives and their actions against various malarial parasites]. | 1976 | 799316 | |
| vaccine against malaria in rodents--a preliminary communication. | 1976 | 798726 | |
| preliminary studies of artificial immunization of rats against plasmodium berghei and adoptive transfer of this immunity by splenic t and t + b cells. | protective t lymphocyte and t+b lymphocyte responses in rats artificially immunized against p. berghei have been demonstrated by adoptive transfer. the techniques used could be developed for detailed analysis of protective lymphocyte responses generated by various methods of immunization, and their relationship to immunity. | 1976 | 798635 |
| abnormal red cells in the peripheral blood of malarian mouse. | 1976 | 798563 | |
| [absence of transplacental passage in congenital trypanosomiasis in mice with trypanosoma equiperdum. comparison with results obtained in congenital malaria (p.b. berghei) in the same animal]. | 1976 | 797328 | |
| suppression of malaria infection by oxidant-sensitive host erythrocytes. | 1976 | 796730 | |
| mouse malaria nephropathy. | mice were infected with 1x 107 plasmodium berghei yoelii parasites intraperitoneally. circulating parasite, malaria antibody and c3 concentrations were measures: parasitaemia and hypocomplementaemia were transient, but the antibody response was persistent. animals were sacrificed at intervals and their kidneys examined: a glomerulonephritis associates with predominantly mesangial deposits of c3, igg1, igm and some iga always developed after 7 days and persisted for up to 6 mth. malaria antigen a ... | 1976 | 796419 |
| [chemotherapeutically active nitro compounds. 2nd communication: nitrodiphenyl sulfones (author's transl)]. | a number of new 4-nitro-4'-amino-diphenyl sulfones and related compounds were prepared and investigated as to their therapeutic activity. they showed a good systemic activity against tubercle bacilli (m. bovis, nmri mouse) and plasmodia (p. berghei, nmri mouse). the test results reveal that the 4-nitro-4'-amino-diphenyl sulfones possess a spectrum of activity similar to that of diamino-diphenyl sulfone (dds). it is assumed that 4-nitro-4'-amino-diphenyl sulfones in vivo are converted into dds de ... | 1976 | 795435 |
| studies on plasmodium ookinetes. 1. isolation and concentration from mosquito midguts. | in a method for isolating a relatively clean suspension of concentrated plasmodium berghei ookinetes from infected midguts of anopheles stephensi at appropriate times after the infective blood meal, the ookinetes are freed from the midguts by enzymatic digestion, and then concentrated by means of a bsa/renografin gradient. the mean number of ookinetes recovered/midgut was 152. more than 95% of the recovered ookinetes were viable by the criteria of motility, incorporation of adenosine and leucine ... | 1976 | 794460 |
| surface properties of extracellular malaria parasites: electrophoretic and lectin-binding characteristics. | the surface charge and lectin-binding capacity of isolated malaria parasites and host erythrocytes were analyzed and compared by chromatographic, electrophoretic, and cytochemical methods. results indicated that at physiological ph values both freshly prepared and glutaraldehyde-fixed parasites and erythrocytes possess a net negative surface charge. both cell types were strongly bound to cation-exchange resins and underwent cathode-directed electrophoretic migration. the isoelectric points for e ... | 1976 | 793992 |
| malarial immunodepression in vitro: adherent spleen cells are functionally defective as accessory cells in the response to horse erythrocytes. | the basis for the depressed response of malarial infected mice to horse red blood cells (hrbc) has been studied in vitro. results presented show that the adherent spleen cells from infected mice (a) are defective in their ability to allow nonadherent spleen cells of both normal and infected mice to respond to hrbc whereas a response does occur with adherent spleen cells from normal mice (b) do not suppress the response of unfractionated spleen cells from normal mice to hrbc (c) contain phagocyti ... | 1976 | 793851 |
| plasmodium berghei: deep vascular sequestration of young forms in the heart and kidney of the white rat. | 1976 | 793548 | |
| a comparison of two different methods for the selection of primaquine resistance in plasmodium berghei berghei. | 1976 | 793547 | |
| [comparative morphology by optical and scanning electron microscopy of erythrocytes from mice infected with plasmodium berghei]. | 1976 | 793494 | |
| cultivation of the erythrocytic stages of plasmodium berghei in leydig cell tumor cultures. | twelve different established cell-lines were used in attempts to cultivate the erythrocytic stages of plasmodium berghei, p. vinckei vinckei, p. coatneyi or p. knowlesi. intracellular parasites were seen in only mouse leydig cell testicular tumor (lct) cultures inoculated with red cells infected with p. berghei. intracellular parasites were present at 15 to 96 h after inoculation, being most numerous at 36 h. most intracellular stages were rings, trophozoites, schizonts and merozoites; gametocyt ... | 1976 | 793226 |
| t cells and protective immunity to plasmodium berghei in rats. | experiments were carried out in which unfractionated spleen cells, and t lymphocyte subpopulations characterized by certain experimental criteria, were isolated at various times from rats infected with plasmodium berghei. by adoptive transfer it was shown that unfractionated spleen cells, and t cells alone, could transfer protection to syngenic recipients as early as 11 days after infection of the cell donors. the protection conferred by t cells increased with the duration of the infection in th ... | 1976 | 791865 |
| cyclophosphamide pretreatment and protection against malaria. | mice pretreated with cyclophosphamide were able to overcome infection from a lethal malarial strain. the development of resistance was preceded by increased hypersensitivity to malarial antigens. hypersensitivity was demonstrable by a delayed footpad swelling technique. | 1976 | 791863 |
| interaction between protective antibodies and malaria parasites (plasmodium berghei): involvement of low avidity antibodies. | free plasmodium parasites were incubated with a standardized amount of immune serum in a small volume of fluid or a larger one. when these parasites were tested for infectivity in and in vivo test system the parasites incubated in the larger volume of fluid were more infective. other aliquots of free p. berghei parasites were incubated with a standaridzed amount of immune serum and then reincubated with or without dilution of the suspending fluid. those parasites reincubated after dilution were ... | 1976 | 790706 |
| physiological and morphological characters in two pyrimethamine-resistant lines of plasmodium berghei sp11 after cryopreservation. | the authors describe the characters in two pyrimethamine-resistant lines of plasmodium berghei berghei sp 11-rr after long storage at very low temperatures. in one case the line had maintained its original virulence but lost its resistance to pyrimethamine. gametocytogenesis increased and cyclical transmission was successful. furthermore, parasites crossed the blood-brain barrier and provoked cerebral malaria. in the other case no physiological changes could be detected. the authors conclude tha ... | 1976 | 790672 |
| [transfusional serology of malaria by an indirect immunofluorescence test using the plasmodium berghei antigen]. | 1976 | 790519 | |
| interaction between trypanosoma brucei and plasmodium berghei in concurrent infections in mice. | in conccurrent infection of trypanosoma brucei rhodesiense and plasmodium berghei yoelii in mice, potentiation of one parasite by the other was observed, especially the malaria by the trypanosome infection. the effect appeared early in the infection. it is suggested that the mutual potentiation of the two infections was probably due to immuno-suppression which both organisms are capable of inducing in the host. | 1976 | 789909 |
| synthesis and properties of mesoionic pyrimido[1,2-b-a1pyridazine-2,4-diones and mesoionic pyridazino[2,3-a-a1-s-trizine-2,4-diones: mesoionic analogs structurally related to fervenulin. | derivatives of two new and unusual classes of heterocycles, possessing structural similarities to the broad spectrum antibiotic fervenulin, were synthesized and examined for in vitro antimicrobial activity. only three of 17 mesoionic pyrimido[1,2-b]pyridazine-2,4-diones exhibited evidence of antimicrobial activity while seven of eight mesoionic pyridazino[2,3-a]-s-triazine-2,4-diones were active against one or more microorganisms. susceptibility toward attack by nucleophiles of both mesoionic py ... | 1976 | 789854 |
| stimulation of resistance in mice to sporozoite-induced plasmodium berghei malaria by injections of avian exoerythrocytic forms. | mice received a series of injections of formalin-killed merozoites (fkm) of exoerythrocytic stages of plasmodium fallax prior to challenge with sporozoites of p. berghei. in one study 4 of 16 fkm-immunized mice never exhibited parasitized erythrocytes after 2 challenges of 10(4) p. berghei sporozoites each, while all control animals died with high parasitemias. fkm-immunized mice were as susceptible as control mice to infections initiated with parasitized erythrocytes. in a second study, 14 of 1 ... | 1976 | 789848 |
| schizont-infected cell enrichment in rodent malaria. | mouse erythrocytes parasitized with plasmodium berghei or plasmodium yoelii were separated by ultracentrifugation using preformed isodensity gradients of the discontinuous type. three fractions were obtained following centrifugation, the upper of which contained greater than 90% of all schizont-infected cells added to the gradient. the gradient material, stractan ii, is an arabinogalactan polysaccharide and appears to yield results similar to those available using gradients of bovine serum album ... | 1976 | 789847 |
| cultivation of the erythrocytic stages of plasmodium berghei in primary bone marrow cells. | cultures of primary bone marrow cells, obtained from the tibiae and femora of hamsters (hbm), mice (mbm), or rats (rbm) were inoculated with red cells infected with plasmodium berghei, p. vinckei vinckei, or p. knowlesi. merozoites, rings, trophozoites, schizonts and a few gametocytes were seen in hbm and mbm cells inoculated with p. berghe-infected red cells. at 1 to 2 or 3 days after inoculation in hbm and mbm, the number of intracellular asexual stages decreased slightly or remained the same, ... | 1976 | 789846 |
| plasmodium berghei: osmotic fragility of malaria parasites and mouse host erythrocytes. | 1976 | 789104 | |
| studies on azadiracta indica in malaria [proceedings]. | 1976 | 788819 | |
| the chemotherapy of rodent malaria, xxvi. the potential value of wr 122,455 (a 9-phenanthrenemethanol) against drug-resistant malaria parasites. | the phenanthrenemethanol compound wr 122,455 is an effective blood schizontocide against lines of plasmodium berghei that are highly resistant to primaquine, sulphonamides, pyrimethamine and cycloguanil. it is also active against the ns line that is moderately resistant to chloroquine. wr 122,455 is inactive against the rc line which is highly resistant to chloroquine. resistance to wr 122,455 is fairly readily developed by the drug-sensitive n strain of p. berghei, using a relapse technique. r ... | 1976 | 788658 |
| the chemotherapy of rodent malaria, xxv. antimalarial activity of wr 122,455 (a 9-phenanthrenemethanol) in vivo and in vitro. | wr 122,455, 3,6-bis-(trifluoromethyl)-alpha-(2-piperidinyl)-9-phenanthrenemethanol hcl, suppresses infection with drug-sensitive plasmodium berghei n strain in mice. it acts rapidly and affects all the stages of the asexual intraerythrocytic parasites, the effective dose levels being about three times those of chloroquine and one-twelfth to one-fifteenth those of quinine. under the influence of wr 122,455 haemozoin seems to disappear from the affected parasites following an initial coarsening of ... | 1976 | 788657 |
| the chemotherapy of rodent malaria, xxiv. the blood schizontocidal action of erythromycin upon plasmodium berghei. | erythromycin inhibits chloroquine-induced pigment clumping in plasmodium berghei in vitro. the drug was therefore tested against infections of p. berghei in mice and was found to be active at non-toxic doses. given orally, the stearate salt was more effective than the base, but subcutaneously the base was more effective than the stearate. erythromycin potentiated the action of chloroquine against two chloroquine-resistant strains of rodent malaria, the mildly resistant ns, and the highly resista ... | 1976 | 788656 |
| [preparation and biological trials of antimalarial sulfa embonates]. | with the purpose of obtaining salts of sulfonamides with low toxicity but prolonged action, embonates of seven known sulfonamides, with antimalarila activity, were prepared by double exchange reaction between embonic acid and the antimalarial agents. six of the seven embonates prepared showed activity against plasmodium berghei in experimentally infected mice, one of them being significantly more active than the original sulfonamide (sulfadimethoxine). | 1975 | 788077 |
| sustained release of an antimalarial drug using a copolymer of glycolic/lactic acid. | 1976 | 787714 | |
| influence of rodent malaria on the course of leishmania enriettii infection of hamsters. | plasmodium yoelii infection was established in hamsters, and the effect of this type of malaria on concurrent leishmania enriettii infection was examined. it was found that the course of the l. enriettii infection was affected by p. yoelii and that this effect depended on the relative timing of the two infections. a chronic malarial infection with plasmodium berghei was also established in hamsters, and this was found to affect the course of a concurrent l. enriettii infection in a similar manne ... | 1976 | 786886 |
| plasmodium berghei: phagocytic activtiy in two strains of rats. | 1976 | 786708 | |
| plasmodium berghei: heat-treated sporozoite vaccination of mice. | 1976 | 786707 | |
| plasmodium berghei: the spleen in sporozoite-induced immunity to mouse malaria. | 1976 | 786705 | |
| plasmodium berghei: use of free blood stage parasites to demonstrate protective humoral activity in the serum of recovered rats. | 1976 | 786704 | |
| specific lymphocyte transformation in murine malaria. | lymphoblast transformation tests were performed on convalescent rats and mice, after infection with plasmodium berghei had been reduced to latency. spleen cells from immune animals reacted in vitro to specific plasmodial antigen and not to control antigen produced from non infected rbc. the response in vitro was dependent on the concentration of the antigen and the time of exposure to it. a correlation was observed between the parasitaemia of the convalescent animal during its acute infection an ... | 1976 | 785850 |
| protective activity in sera from mice immunized against plasmodium berghei. | 1976 | 784936 | |
| [antimicrobial action of the combination sulfamoxole/trimethoprim in vivo (author's transl)]. | the experimental infections of the mouse by gram-positive and gram-negative germs are effectively treated with the combination of n1-(4,5-dimethyl-2-oxazolyl)-sulfanilamide (sulfamoxole) and 2,4-diamino-5-(3,4,5-trimethoxy-benzyl)-pyrimidine (trimethoprim) (cn 3123, nevin, supristol). the potentiating effect of both substances is demonstrated by the calculated index of the synergistic effect. the therapeutic efficacy of the combination sulfamoxole/trimethoprim is proved by two models of experime ... | 1976 | 782473 |
| [behavior of a strain of p.berghei after low temperature preservation during more than 10 years]. | 1975 | 782384 | |
| the plasmodium berghei-infection in isogenic f1 (c57b1 x dba)- mice. iii. neonatal thymectomy and cell transfer experiments. | in neonatally thymectomized f1(c57bl x dba)-mice the course of an infection with plasmodium berghei, strain k 173, was unaltered if compared with the course in normal animals. no shortening of the survival time was observed. cell transfer experiments were carried out. in numerous trials it was not possible to convey the protective immunity of immune animals to non-immune animals by the transfer of lymphoid cells. if an acquired immunity was destroyed by heavy x-irradiation it could be restored b ... | 1976 | 781956 |
| antimalarials. 9. methylthio- and methylsulfonyl-substituted 9-phenanthrenemethanols. | nine di- and trisubstituted 9-phenanthrenemethanols bearing methylthio and methylfulfonyl substituents in the 2 and/or 6 positions of the phenanthrene nucleus were prepared and screened for antimalarial activity against plasmodium berghei in mice. six of the nine compounds were curative at or below 160 mg/kg. the most active structures contained a methylthio substituent in combination with two chlorine atoms. | 1976 | 781249 |
| synthesis, antimalarial activity, and phototoxicity of some benzo(h)quinoline-4-methanols. | nine alpha-dibutylaminomethylbenzo[h]quinoline-4-methanols were synthesized from the corresponding 1-amino-naphthalenes by the following sequence: 1-aminonaphthalene leads to 1h-benz[g]indole-2,3-dione leads to benzo[h]quinoline-4-carboxylic acid leads to acid chloride leads to bromomethyl ketone leads to epoxide leads to benzo[h]quinoline-4-methanol. several acid chlorides substituted in the 3 position reacted incompletely with ethereal diazomethane but were efficiently converted, without isola ... | 1976 | 781245 |
| antimalarials. 3. 1,2,4-triazines. | the syntheses of a number of substituted 1,2,4-triazines as potential antimalarials are described. the structural requirements for antimalarial activity are discussed with reference to the substituents of a phenyl group in the 6 position and amino groups at the 3 and 5 positions. of the compounds tested, 2,5, and 7 produced cures in mice infected with plasmodium berghei. compounds 2(3,5-diamino-6-(4-trifluoromethylphenyl)-1,2,4-triazine),3,5,8,12,and 37 produced cures in chicks infected with pla ... | 1976 | 781244 |
| adoptive transfer of immunity to plasmodium berghei with immune t and b lymphocytes. | immunity to malarial infection may be transferred with immune lymphocytes. this study was designed to determine which lymphocyte type is responsible for the adoptive transfer of immunity to malarial infection. in one set of experiments, the ability of immune t and b lymphocytes, separated by passage through nylon-wool columns, to transfer immunity to infection was determined. in another experiment, the effect of killing t lymphocytes with anti-theta serum on the transfer of immunity was determin ... | 1976 | 780273 |
| t and b cell population changes in young and in adult rats infected with plasmodium berghei. | malaria infection in young rats is characterized by high parasitemia, severe anemia, and death. parasitemia is lower in older rats, and the rats usually survive. this study was designed to investigate the immunological basis of this difference. t cell numbers in the thymuses and spleens of young (4 weeks old) and in adult (18 weeks old) infected and control rats were determined by killing with anti-theta serum and complement. the number of complement receptor lymphocytes (b cells) in spleens was ... | 1976 | 780272 |
| plasmodium berghei: combining folic acid antagonists for potentiation against malaria infections in mice. | 1976 | 780121 | |
| plasmodium berghei: phase contrast and electron microscopical evidence that certain antimalarials can both inhibit and reverse pigment clumping caused by chloroquine. | 1976 | 780119 | |
| plasmodium berghei: development of resistance to clindamycin and minocycline in mice. | 1976 | 780118 | |
| plasmodium berghei: adaptation of a mouse-adapted strain to the mongolian jird (meriones unguiculatus); infectivity and immunogenicity. | 1976 | 780117 | |
| the reactivity of spleen cells from malarious rats to non-specific mitogens. | the reaction of spleen cells from rats infected with plasmodium berghei to non-specific mitogens has been measured. the cells have been stimulated in vitro by phytohaemagglutinin, concanavalin-a and by bacterial lypopolysaccharide. in addition the release of lymphocyte activating factor (laf) by splenic macrophages has been assayed using a heterologous thymocyte culture. the reactivity of spleen lymphocytes from malarious rats is severly affected. the cells do not react either to the t cell-spec ... | 1976 | 780016 |
| a comparison of methods used for the removal of white cells from malaria-infected blood. | 1976 | 779686 | |
| cross reactivity between anaplasma marginale and two plasmodium species as demonstrated by passive hemagglutination. | two types of antigens were prepared from each of 3 partially purified preparations of anaplasma marginale, plasmodium lophurae, and p berghei. hemagglutination tests were conducted with homologous serums to detect antigenic relationships between these organisms. serums were also absorbed with both homologous and heterologous antigen preparations. cross reactivity between these organisms was observed. | 1976 | 779540 |
| chronic malarial infection in balb/c mice. effect on the immune response to sheep erythrocytes and histological changes in the liver and spleen. | chronic malarial infection was established in balb/c mice by following plasmodium berghei yoelii with p.b. berghei infection. it was found that the igg plaque-forming cell response to sheep erythrocytes was depressed for at least six months. a preliminary investigation of the histological changes in the spleen and liver is described. the possibility that chronically infected mice could serve as a model for the tropical splenomegaly syndrome is discussed. | 1975 | 779156 |
| synthesis and antimalarial activity of dibenz[c, e]azepine derivatives. | a series of 6-alkyl-2,10-bis(trifluoromethyl)-5h-dibenz-[c,e]azepines were synthesized via a condensation reaction between 5,5'-bis(trifluoromethyl)-2,2'-diformylbiphenyl and the appropriate amine. these compounds were screened for antimalarial activity and were found to be inactive. | 1976 | 778378 |
| new synthesis of substituted pyrrolo[1,2-alpha][1,3]diazepine and its pharmacological activity. | a facile route for the synthesis of the substituted pyrrolo[1,2-alpha][1,3]diazepine nucleus from readily available starting material is reported. the compound was tested for antimalarial activity in mice, antineoplastic activity in mice, acute hypotensive activity in rats and dogs, effect on cholesterol-lipoprotein levels in rats, anti-inflammatory activity in rats, antiviral activity in mice, cns depressant or stimulant activity in mice, diuretic activity in fasted rats, and antidiabetic activ ... | 1976 | 778377 |
| viruslike particles in malaria parasites. | the ultrastructural appearance of viruslike particles in several malaria parasites at different times in sporogony is described in detail. emphasis is placed on particle size, 42 to 52 nm, density and the presence or absence of geometric configuration of particle aggregations in p. berghei ookinetes, and p. gallinaceum early oocysts. this particle appearance is compared with that noted in later oocysts of p. berghei, p. gallinaceum, and p. c. bastianelli and with negatively-stained particles obt ... | 1976 | 778372 |
| spleen reactivity in experimental malaria of rodents. | 1975 | 776124 | |
| proceedings: the chemotherapeutic action of pam-780 against plasmodium berghei malaria in mice. | 1975 | 775791 | |
| antimalarial activity of some novel derivatives of 2,4-diamino-5(p-chlorophenyl)-6-ethylpyrimidine (pyrimethamine). | thirteen new analogs of 2,4-diamino-5(p-chlorophenyl)-6-ethylpyrimidine (daraprim, pyrimethamine) in which the alph position of the 6-ethyl substituent was modified were prepared. the respective oxygens analogs (ketals, ketone, alcohol), the dimethyl hydrazone, and the nitrone displayed activities in the range of 1/4 to 1/16 that of pyrimethamine toward plasmodium berghei in mice. the therapeutic ratios of some of these compounds may be slightly better than that of pyrimethamine. | 1976 | 775088 |
| antimalarials v: aminobenzothiazoles. | four mono- and dialkylated 4-aminobenzothiazoles (vii-x) were prepared as analogs of potent causal prophylactic drugs in the 8-aminoquinoline series. compounds vii and viii were toxic at 80 mg/kg in the chick; ix was inactive at 640 mg/kg. in a sporozoite-induced mouse test system, x was inactive at 30 mg/kg and toxic at 480 mg/kg. none of the compounds was active as a suppressive drug. | 1976 | 775054 |
| an in vitro assay for t cell immunity to malaria in mice. | after infection with a nonlethal strain of murine malaria (17xnl plasmodium berghei yoelli), balb/c mice are then resistant to a lethal strain (17xl p.b. yoelli). balb/c mice were infected with 17xnl, anc challenged 3 weeks later, after clearing their parasitemias, with 17xl. three weeks thereafter, spleen cells from such immune animals were used to define an early peaking t-dependent (anti-theta sensitive) antigen-specific proliferative response when incubated in vitro with 17xl infected rbc, o ... | 1976 | 774978 |
| plasmodium berghei: ii. immunobiological properties of fractions of a soluble extract. | 1976 | 773656 | |
| plasmodium berghei: i. immunochemical properties of fractions of a soluble extract. | 1976 | 773655 | |
| plasmodium berghei berghei: irradiated sporozoites of the anka strain as immunizing antigens in mice. | 1976 | 773654 | |
| nonspecific resistance to infection induced in mice by a water-soluble adjuvant derived from mycobacterium smegmatis. | the effect of a nontoxic, water-soluble adjuvant (neo-wsa) from delipidated cells of mycobacterium smegmatis on the susceptibility of mice to infection with four challenge organisms was studied. an intravenous dose of 1 mg of neo-wsa per mouse 24 hr before challenge enhanced resistance to infection with a fungus (candida albicans), a gram-negative bacterium (klebsiella pneumoniae), and a gram-positive bacterium (streptococcus pneumoniae). protection by neo-wsa was not significant when the mice w ... | 1976 | 772130 |
| adoptive transfer of immunity to plasmodium berghei by a population of immune rat spleen cells resistant to cyclophosphamide. | 1976 | 770355 | |
| a temporal relationship between reticuloendothelial system phagocytic alterations and antibody responses in mice infected with plasmodium berghei (nyu-2 strain). | malaria-induced immunosuppression has been demonstrated in humans and experimental animals. the suppressed immune response has been suggested to be primarily humoral and not cellular in nature, since classical lymphocytic cell-mediated responses have been reported to be normal. since previous results have demonstrated that an impairment in macrophage antigen processing may be a contributing factor in malaria-induced immunosuppression, the present studies were conducted to determine if the macrop ... | 1976 | 769577 |
| plasmodium berghei: characteristics of a selected population of small free blood stage parasites. | the characteristics of a selected population of small blood stage parasites obtained by differential centrifugation of a population of p. berghei parasites freed by continuous flow sonication are described. about 10% of these free parasites are merozoites, many others are transitional forms having some merozoite characteristics. the parasite preparations are infectious and sufficiently resistant to incubation at 37 degrees c to be useful experimentally. disc gel electrophoresis analysis indicate ... | 1976 | 769270 |
| the plasmodium berghei-infection in isogenic f1(c57b1 x dba)-mice. ii. antibodies and antigens in the serum. | using the fluorescent antibody technique it was possible to demonstrate antibodies in the sera of f1(c57b1 x dba)-mice already during the first week of infection with plasmodium berghei, strain k 173. these antibodies reached high titers during the second and third week, but, nevertheless, the animals died from the infection. coincidently with the fat-antibodies plasmodial antigens could be found in the sera of infected mice. the numbers of these antigens increased in the course of the infection ... | 1976 | 769269 |
| antimalarials. 11. 2-vinylogs of substituted 2-aryl-4-quinoline amino alcohols. | 3-(p-chlorobenzylidene)-5, 7-dimethyl-2, 3-dihydro-1h-cyclopenta[b]quinoline-9-(di-n-butylaminomethyl)methanol and 2-[beta-(p-chlorostyryl)]-6, 8-dimethylquinoline-4-(di-n-butylaminomethyl)methanol were synthesized from 6, -8-dimethyl-4-hydroxycarbostyril by 3, 3-dichlorination, dimethoxylation th the 3-ketal, basic hydrolysis to the glyoxal acetal, pfitzinger condensation with cylopentanone or acetone to the 2, 3-trimethylene or 2-methylquinoline, condensation with p-clphcho at the 2-methylene ... | 1976 | 768474 |
| antimalarials. 8. synthesis of amino ethers as candidate antimalarials. | based upon the antimalarial activities demonstrated by compounds i and ii a series of amino ethers represented by structures iii-vi was synthesized. these structures incorporated several modifications of compound ii. the compounds prepared displayed no activity in either the rane p. berghei mouse screen or the rane p. gallinaceum sporozoite-induced chick test. | 1976 | 768473 |
| malaria: decreased survival of transfused normal erythrocytes in infected rats. | 1976 | 768435 | |
| malaria: macrophage migration inhibition factor (mif). | 1976 | 768434 | |
| the plasmodium berghei-infection in isogenic f1 (c57bl x dba)-mice. i. the course of the infection and immunization experiments. | the malarial infection caused by plasmodium berghei (strain k 173) was observed in the isogenic mouse strains c3h, c57bl, dba, and the f1 (c57bl x dba)-hybrids. in addition immunization experiments were carried out by intermittent suppression of the parasite multiplication through maintaining the infected animals on a milk diet for various length of time. the f1-hybrids were the most resistant mice and immunization was most effective in these animals, too. but if the course of the infection was ... | 1975 | 766337 |
| proceedings: pharmacology of plasmodium berghei. | 1975 | 766321 | |
| proceedings: the t-cell response in murine malaria. | 1975 | 766320 | |
| proceedings: the passive transfer of immunity to plasmodium berghei yoelii. | 1975 | 766319 | |
| proceedings: changes in pha and lps responsiveness in murine malaria. | 1975 | 766318 | |
| protection of mice against babesia and plasmodium with bcg. | 1976 | 765838 | |
| synthesis of 5-substituted aminomethyluracils via the mannich reaction. | an extension of the mannich reaction, in which aminomethylation of the five position of uracil, is reported. thus, primary and secondary alkylamines and primary aromatic amines containing ring-activating groups led to the title compounds 3-10. compound 11 in which the aromatic ring contains the ring-deactivating nitro group was synthesized in an alternative way. all compounds were characterized by their elemental and spectral properties. | 1976 | 765460 |
| dynamics of thymidine incorporation by spleen cells from rats infected with plasmodium berghei. | the in vitro incorporation of thymidine by spleen cells of rat infected with plasmodium berghei was higher than that of normal rat spleen cells. the incorporation was proportional to the number of cells in the system and was related to the day of infection, e.g. spleen cells from malarious rats incorporated up to forty times as much thymidine as did normal spleen cells 21 days after inoculation. at the same time, the response of the malarious spleen cells to phytohaemagglutinin (pha) was only on ... | 1975 | 765025 |
| babesia rodhaini: passive protection of mice with immune serum. | immune serum delayed the onset of parasitemia in both intact and splenectomized mice, but it neither prevented the development of babesia rodhaini infection nor protected the mice from death even with further supplementation of immune serum during the infection. the protective antibodies in the serum are more effective in their action on free b. rodhaini parasites than on infected erythrocytes; the parasites (free or inside the red cells) being direct targets for the antibodies. passive administ ... | 1978 | 726044 |
| lower azure b methylene blue ratios in giemsa type blood and malaria stains. | starting from ancient reports that rare samples of methylene blue were apparently sufficiently contaminated with azures to give red plasmodial and red purple nuclear chromatin in chenzinsky type methylene blue eosin stains, it was decided to determine how little azure b would suffice for such staining in methylene blue eosin stains. the traditional 1902 giemsa had an azure : methylene blue : eosin ratio of about 6 : 3 : 6.3 : 10; lillie's 1943 formula had a 5 : 7 : 10 ratio. in the current serie ... | 1978 | 663946 |
| antimalarial activity of saccharidic polymers of dapsone and sulfadimethoxine. | with the purpose of obtaining pro-drugs of dapsone and sulfadimethoxine, those chemotherapeutic agents were attached through covalent bonding to starch polymeric dialdehyde (sumstar-190). the antimalarial activity of the two resulting compounds - the dapsone saccharidic polymer (ps6) and the sulfadimethoxine saccharidic polymer (ps7) - in mice experimentally inoculated with plasmodium berghei was significantly increased with this molecular modification. mice infected with malaria and kept withou ... | 1978 | 648235 |