Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| accelerated solute clearance in pneumocystis carinii pneumonia. | a radioaerosol clearance test was used to detect lung injury in 12 patients with acquired immune deficiency syndrome (aids) and pneumocystis carinii pneumonia documented by bronchoscopy. the clearance of 99mtc-dtpa was elevated over most regions of interest in all of these patients. in each of 7 subjects who responded to trimethoprim-sulfamethoxazole therapy, clearance returned toward normal. average clearances were either normal or very slightly above the 95% expected upper limit of normal in e ... | 1987 | 3551706 |
| pneumocystis carinii pneumonia. | pneumocystis carinii pneumonia (pcp) has become one of the most important of the opportunistic pulmonary infections of the 1980s. in view of the rapidly expanding population of immunosuppressed patients, many more cases of pcp may be expected in the future. the history, microbiology, pathogenesis, pathology, clinical and laboratory features, diagnosis, treatment, course and prognosis of this disease are reviewed. | 1987 | 3551122 |
| a comparison of the antigenic characteristics of rat and human pneumocystis carinii by immunoblotting. | the antigenic characteristics of rat pneumocystis carinii obtained from infected lungs and grown in tissue culture were compared with the properties of human p. carinii obtained from the lungs of aids and non-aids patients by the immunoblotting technique, using different sources of antibody. major immunoreactive bands of 45, 50, and 116 kd were found in both lung and tissue culture-derived rat p. carinii, suggesting the organism retains its antigenic characteristics in short-term culture. the pr ... | 1987 | 3549900 |
| patterns of antibody response in individuals infected with the human immunodeficiency virus. | immunofluorescence and immunoblot assays were conducted on 488 sera from patients with aids and clinically healthy individuals at risk for infection by the human immunodeficiency virus. of these, 360 contained antiviral antibodies, and nearly all reacted with the envelope precursor glycoprotein gp160. sera from 103 individuals for whom a complete clinical history was available were evaluated in detail. most sera recognized both the gp160 and the p55 gag precursor protein. because these two antig ... | 1987 | 3546516 |
| histoenzymological study of selected dehydrogenase enzymes in pneumocystis carinii. | the metabolic activity of pneumocystis carinii cysts was studied histochemically by a tetrazolium dye technique to assess substrate-specific dehydrogenase activity. lactate dehydrogenase, succinate dehydrogenase, and glutamate dehydrogenase produced moderate-to-strong reactions in the cysts, whereas glucose-6-phosphate dehydrogenase had little if any reactivity. these results suggest that pneumocystis cysts have some of the enzymes necessary for glycolysis, krebs cycle activity, and intermediary ... | 1987 | 3546138 |
| infectious complications in heart transplant recipients receiving cyclosporine and corticosteroids. | the rate of infectious complications differed significantly in two groups of heart transplant recipients who received different immunosuppressive regimens. compared with patients who received conventional immunosuppression, patients treated with cyclosporine had a lower rate of infectious complications, and the contribution of infection to observed mortality was lower. herpes simplex virus caused less morbidity and there were fewer active cytomegalovirus infections in seropositive recipients tre ... | 1987 | 3541723 |
| pneumocystis carinii pneumonia. cytologic manifestations and rapid diagnosis in routinely prepared papanicolaou-stained preparations. | in this study of 28 immunocompromised patients, it was found that pneumocystis carinii pneumonia could be easily and reliably diagnosed by examination of routinely prepared, papanicolaou-stained cellular samples obtained by bronchoalveolar lavage, bronchial brushing, and bronchial washing. the distinctive intra-alveolar exudate of pneumocystosis observed in lung biopsy specimens was readily discernible in all of the cellular samples that demonstrated p. carinii by special stains. the exudate was ... | 1986 | 3541586 |
| preliminary studies on the development of a vaccine for pneumocystis carinii. i. immunological and biochemical characterization. | initial progress has been made toward the development of an experimental vaccine or immunostimulant for pneumocystis carinii. antigen derived from cell culture propagated p. carinii proved to be a potent immunogen in the rabbit and antibody thus produced demonstrated identity with intact murine and human lung-derived p. carinii organisms. reactivity of the antibody with p. carinii soluble antigen in the blood of rats and human subjects with p. carinii pneumonitis (pcp) was demonstrated by the ou ... | 1986 | 3541429 |
| pneumocystis carinii and toxoplasma gondii infections in patients with aids. | pneumocystis carinii and toxoplasma gondii are the commonest protozoans causing infections in patients with acquired immunodeficiency syndrome (aids). p. carinii is almost exclusively a pulmonary pathogen and caused the commonest serious infection experienced by aids patients. the clinical findings are those of progressive pneumonia. diagnosis requires microscopic examination of lower respiratory secretions or lung tissue. pentamidine or combinations of trimethoprim and sulfamethoxazole are equa ... | 1986 | 3541120 |
| pneumocystis carinii pneumonia. | 1986 | 3538805 | |
| pulmonary nocardiosis in the acquired immunodeficiency syndrome. diagnosis with bronchoalveolar lavage and treatment with non-sulphur containing drugs. | a patient with the acquired immunodeficiency syndrome (aids) presented with pneumocystis carinii pneumonia and pulmonary nocardiosis. the nocardial lesions appeared small and localized on chest radiograph. on two separate occasions, nocardial organisms were absent in transbronchial lung biopsy specimens, but were identified in bronchoalveolar lavage fluid probably because the latter specimen sampled a larger area of lung. the patient was initially treated with trimethoprim-sulfamethoxazole (tmp/ ... | 1986 | 3536345 |
| analyses of rat pneumocystis carinii antigens recognized by human and rat antibodies by using western immunoblotting. | the major pneumocystis carinii antigens inducing antibody responses in infected hosts were identified by western immunoblotting techniques. the biochemical nature of these antigens was also elucidated. sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by protein staining revealed a major component with a molecular weight (mw) of greater than 205,000. this major component disappeared and a new major protein staining component of approximately 110,000 to 116,000 mw appeared when e ... | 1986 | 3531021 |
| [pneumocystis carinii infections in a danish case population of renal transplants]. | 1986 | 3529553 | |
| prevalence of pneumocystis carinii in wild rodents in japan. | during the period from november 1980 to april 1984, 292 small wild rodents were captured in 6 localities in japan. eleven out of 142 apodemus speciosus, 1 out of 11 a. argenteus, 4 out of 40 microtus montebelli and 2 out of 3 mus musculus were positive for pneumocystis carinii. the intensity of infection was generally low and the infection rate did not show any significant difference between sexes of the host animals. the seasonal prevalence of infection in a. speciosus was not remarkable, but w ... | 1986 | 3526764 |
| acquired immune deficiency syndrome: review. | acquired immunodeficiency syndrome (aids) is reviewed for dental practitioners, with an emphasis on oral findings; the clinical course, diagnosis, reporting, treatment, prognosis, transmission, and epidemiology are also covered. hiv infection has an incubation period that may be associated with glandular fever, a prodrome called aids-related complex (arc) characterized by lymphadenopathy, low fever, weight loss, night sweats, diarrhea, oral candidosis, nonproductive cough and recurrent infectio ... | 1986 | 3524629 |
| development of murine monoclonal antibodies to pneumocystis carinii. | relatively little is known about the antigenic structure of pneumocystis carinii and the immunopathogenesis of pneumonitis caused by p. carinii. to begin to define the antigenic character of the surface of this organism, we have produced murine monoclonal antibodies that react with the surface of p. carinii (obtained from rats), as detected by immunofluorescence and immunoelectron microscopy. immunoblot analysis revealed that the six antibodies described in this report bound an antigen with an a ... | 1986 | 3522758 |
| trimethoprim-sulfamethoxazole or pentamidine for pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. a prospective randomized trial. | forty patients with the acquired immunodeficiency syndrome (aids) and their first episodes of pneumocystis carinii pneumonia were assigned at random to receive either trimethoprim-sulfamethoxazole or pentamidine isethionate. the two groups did not differ significantly in the severity of pulmonary or systemic processes at enrollment. five patients treated initially with trimethoprim-sulfamethoxazole and one patient treated initially with pentamidine died during the 21-day treatment period (p = 0. ... | 1986 | 3521428 |
| [clinical aspects and treatment of pneumocystis carinii infections]. | 1986 | 3518567 | |
| respiratory failure in patients with acquired immunodeficiency syndrome and pneumocystis carinii pneumonia. | seven patients with acquired immunodeficiency syndrome (aids) and pneumocystis carinii pneumonia were studied to define the pathophysiology of their respiratory failure. the patients had fever, cough, dyspnea, hypoxemia, and diffuse infiltrates on chest x-ray. biopsies revealed a spectrum of alveolar filling, interstitial edema and infiltration, and fibrosis. the patients were studied on mechanical ventilation to assess the effect of positive end-expiratory pressure (peep) and supplemental oxyge ... | 1986 | 3516574 |
| serologic methods for the early diagnosis of pneumocystis carinii infection in renal allograft recipients. | because of the nephrotoxic action of trimethoprimsulfamethoxazole (tmp-smx) in cyclosporine (csa)-treated patients, combined with the (csa)-treated patients, combined with the possibility of selecting resistant gram-negative or nocardia asteroides organisms, a monitoring tool to detect early pneumocystis carinii (pc) infection permitting a selective treatment approach is highly desirable. a review of 401 consecutive renal transplants revealed 26 cases (18 suspected and 8 histologically proved) o ... | 1986 | 3515643 |
| production of monoclonal antibody against pneumocystis carinii by using a hybrid of rat spleen and mouse myeloma cells. | it has been difficult to obtain pure pneumocystis carinii antigen either from cultures or from infected lungs for use in producing a specific antibody against p. carinii. this report describes an approach toward producing a monoclonal antibody that bypasses the antigen purification steps. p. carinii infection was developed in sprague-dawley rats by the method of immunosuppression with cortisone. the infected lungs were homogenized, and the homogenate was used to immunize sprague-dawley rats. rat ... | 1986 | 3514660 |
| [lung complications in aids]. | a short description of epidemiologic and clinical facts correlated with the acquired immunodeficiency syndrome (aids) is followed by a report on the manifestation of pulmonary infections mostly effected by pneumocystis carinii. two examples out of four cases will demonstrate the radiographic appearance of the pneumocystis carinii pneumonia and clinical data. only in rare cases does it seem possible to reduce the fatal outcome by early diagnosis. | 1986 | 3513241 |
| excess prevalence of pneumocystis carinii pneumonia in patients treated for lymphoma with combination chemotherapy. | a significantly greater prevalence of interstitial pulmonary infiltrates and pneumocystis carinii pneumonitis occurred on one arm of a randomized study comparing promace-cytabom (prednisone, methotrexate with leucovorin, doxorubicin, cyclophosphamide, etoposide; cytarabine, bleomycin, vincristine, methotrexate with leucovorin) to promace-mopp (promace, mechlorethamine, vincristine, prednisone, procarbazine) chemotherapy in patients with lymphoma. of the 37 patients receiving promace-cytabom, 13 ... | 1986 | 3511821 |
| recurrent salmonella infection with a single strain in the acquired immunodeficiency syndrome. confirmation by plasmid fingerprinting. | five weeks before the development of acquired immunodeficiency syndrome (aids), a 38-yr-old homosexual man had symptomatic gastroenteritis that resolved without antibiotic treatment. his stool culture was positive for salmonella typhimurium at that time. the patient subsequently developed pneumocystis carinii pneumonia and received a 10-day course of intravenous trimethoprim-sulfamethoxazole. he developed salmonella bacteremia 4 months later. the salmonella isolates from the stool and blood were ... | 1986 | 3510806 |
| development and characterization of monoclonal antibodies to pneumocystis carinii. | hybridoma-producing monoclonal antibodies against pneumocystis carinii were produced by the fusion of nonsecreting mouse myeloma cells (p3x63-ag8.653) with splenocytes from balb/c mice that had been immunized with partially purified preparations of p. carinii. of 227 hybridoma clones producing antibodies against p. carinii, as measured by an enzyme-linked immunosorbent assay, 12 monoclonal antibodies showing the highest reactivity in the enzyme-linked immunosorbent assay were further characteriz ... | 1986 | 3510163 |
| [pneumonia caused by pneumocystis carinii in aids]. | 1987 | 3502489 | |
| separation of trophozoites of pneumocystis carinii from lung of the inoculated nude rat. | 1987 | 3502477 | |
| pulmonary manifestations of the acquired immunodeficiency syndrome. | between 1983 and 1985, 71 patients with the acquired immunodeficiency syndrome (aids) were evaluated. pulmonary manifestations were present in 42 patients (59%). pneumocystis carinii pneumonia (pcp) was the most common pulmonary manifestation, present in 32 patients (45%). other pulmonary findings were cytomegalovirus pneumonia (one patient), candida pneumonia (one patient), cryptococcal pneumonia (one patient), bacterial pneumonia (three patients), nonspecific pneumonitis (three patients), kapo ... | 1987 | 3502322 |
| an autopsy-proved aids patient with pneumocystis carinii pneumonia. | 1987 | 3502135 | |
| doses and side effects of co-trimoxazole in treatment of aids associated pneumocystis carinii pneumonia. | 1987 | 3502075 | |
| freeze-fracture studies on pneumocystis carinii. iii. fine structure of the precyst and the cyst. | the ultrastructure of the precyst and cyst of pneumocystis carinii was investigated by the freeze-fracture method. the most interesting point in this study is the alteration in the number of intramembranous particles (imps) of the plasma membrane during the formation of intracystic bodies. the imp density of delimiting membrane originating from the precyst plasma membrane, which later becomes the plasma membrane of the intracystic body, was low. in contrast, that of the plasma membrane of the in ... | 1987 | 3501864 |
| severe ventricular arrhythmia during pentamidine treatment of aids-associated pneumocystis carinii pneumonia. | 1987 | 3501769 | |
| the role of bronchoalveolar lavage in the diagnosis of suspected opportunistic pneumonia. | we report 50 immunocompromised patients with pulmonary infiltrates who underwent fibreoptic bronchoscopy, including bronchoalveolar lavage, on 56 occasions. the underlying diseases were mostly lymphoma, leukemia, other malignancies and renal failure. the commonest immunodeficiency factors were chemotherapy, steroids and neutropenia. a positive diagnosis could be made from analysis of the bronchoalveolar lavage on 59% (33/56) occasions. this was a comparable yield to transbronchial lung biopsy 57 ... | 1987 | 3501711 |
| the acquired immune deficiency syndrome: a report of the first case in malaysia. | the 1st case of acquired immunodeficiency syndrome (aids) in malaysia was detected in 1987, 1 year after the ministry of health established a national aids task force. the patient was a 45-year-old chinese man of malaysian origin who had been living overseas for the past 30 years. the patient denied any homosexual relationships, blood transfusions, of intravenous drug use; however, he reported multiple sexual partners 10 years prior to developing aids. at hospital admission, the patient was i ... | 1987 | 3501533 |
| high-performance liquid chromatographic method for measurement of pentamidine in plasma and its application in an immunosuppressed patient with renal dysfunction. | a rapid method for the quantitation of pentamidine in plasma by high-performance liquid chromatography is described. pentamidine was extracted from plasma using a mixed solvent of 40% acetonitrile in chloroform. reversed-phase chromatography was then performed on a mu bondapak c-18 column, using a mobile phase of acetonitrile containing 0.1% h3po4 and 0.1% nacl (20:80) and the eluting peaks detected by their uv absorbance at 262 nm. the assay had a within-day coefficient of variation of less tha ... | 1987 | 3501181 |
| multiple pulmonary cavities--an unusual complication of pneumocystis carinii pneumonia. | cavitation is a most unusual radiological feature of pneumocystis carinii pneumonia (pcp). autopsy evidence of cavities in pcp is poorly documented. we describe a case of fatal pcp occurring in a patient with the acquired immune deficiency syndrome; the pcp was associated with radiological as well as autopsy evidence of large intrapulmonary cavities. these cavities are ascribed to pneumocystis carinii infection, since other possible causes were excluded. | 1987 | 3501169 |
| diagnostic bronchoalveolar lavage in children with aids. | between october, 1985 and may 1987, 29 children (mean age 22 +/- 22 months, range 2-54 months) with aids or arc developed acute respiratory illness. the initial diagnostic procedure was flexible fiberoptic bronchoscopy, with bronchoalveolar lavage (bal). bal was positive for pneumocystis carinii in 14 and for respiratory syncytial virus, staphylococcus aureus, and escherichia coli in 3 additional patients. subsequent lung tissue analysis and/or clinical course suggested no false negative lavages ... | 1987 | 3501100 |
| pneumocystis carinii pneumonia following 5-fluorouracil administration. | a 54-year-old man who had been treated with monthly courses of 5-fluorouracil for one year developed pneumocystis carinii pneumonia. no evidence of significant, permanent, immunologic impairment was evident one year after the patient became infected. an infection associated with 5-fluorouracil treatment is implicated. | 1987 | 3501015 |
| diagnosis of lung disease in acquired immune deficiency syndrome: biopsy or cytology and implications for management. | one hundred and twenty consecutive bronchoscopic examinations were carried out on 80 patients with acquired immune deficiency syndrome (aids) between january 1982 and december 1986. ninety one paired biopsy and cytology specimens from 72 of these patients were analysed. there was no significant difference between biopsy and cytology in diagnosing pneumocystis carinii pneumonia (0.95 greater than p greater than 0.1). in 10 cases p carinii pneumonia was diagnosed by biopsy but not cytology and in ... | 1987 | 3500967 |
| clinical features of 100 human immunodeficiency virus antibody-positive individuals from an alternate test site. | we evaluated 100 human immunodeficiency virus (hiv) antibody-positive persons from the only alternate test site in los angeles. thirty-five subjects complained of systemic symptoms suggestive of hiv infection and 65 were completely asymptomatic. irrespective of symptoms, the group as a whole demonstrated clinical and laboratory evidence of immunodeficiency. eighty had generalized lymphadenopathy, 16 onychomycosis, six oral candidiasis, and two biopsy-proved kaposi's sarcoma. seventy-seven were a ... | 1987 | 3500685 |
| [contribution of chest radiology to the diagnosis of hiv virus infection]. | after revising literature concerning pneumocystis carinii pneumoniae (pcp), the authors undertook a close examination of the immunological system of the hivab-positive patients that suffered opportunistic pneumopathy from pcp. hundred-forty-three cases of hivab-positive (mean age of 29), prevalently heroin drug-users, were studied. there were 13 aids, 26 arc, 91 las cases and 13 patients with only ab positivity for hiv. four hundred chest radiographs were examined without previous knowledge of c ... | 1987 | 3500488 |
| [pneumocystis carinii pneumonia (pneumocystosis)]. | in former times pneumocystis carinii (pc) primarily affected premature infants. more recently, it has proved to be one of the major infectious complications among immunocompromised patients, particularly those with aids. the most frequent radiographic feature is diffuse, bilateral alveolar and interstitial perihilar shadowing, spreading in a butterfly pattern. the typical findings may mimic other infectious diseases, but the presence of large pleural effusions of hilar adenopathy is evidence aga ... | 1987 | 3500484 |
| scanning electron microscopy with backscattered electron imaging to identify pneumocystis carinii. | 1987 | 3500413 | |
| survival with the acquired immunodeficiency syndrome. experience with 5833 cases in new york city. | in a cohort of 5833 subjects in whom the acquired immunodeficiency syndrome (aids) was diagnosed in new york city before 1986, the cumulative probability of survival (mean +/- se) was 48.8 +/- 0.7 percent at one year and 15.2 +/- 1.8 percent at five years. the group with the most favorable survival rate--white homosexual men 30 to 34 years old who presented with kaposi's sarcoma only--had a one-year cumulative probability of survival of 80.5 percent; that group was used as the reference group in ... | 1987 | 3500409 |
| aids in louisiana. unusual pneumocystis carinii pneumonia in an aids patient. | 1987 | 3500272 | |
| [pneumocystis carinii pneumonia in hiv infection. diagnosis and therapy]. | 1987 | 3500030 | |
| prognostic factors and life expectancy of patients with acquired immunodeficiency syndrome and pneumocystis carinii pneumonia. | to assess determinants of prognosis for 43 patients with the acquired immunodeficiency syndrome (aids) and pneumocystis carinii pneumonia, objective clinical and histopathologic characteristics were analyzed for acute and long-term prognostic significance. severe abnormalities on initial chest radiographs and alveolar-arterial oxygen differences (aapo2) greater than 30 mm hg were associated with higher mortality during the period of treatment for the acute episode (p less than 0.05). decreased l ... | 1987 | 3499836 |
| hypoxemia with normal chest roentgenogram due to pneumocystis carinii pneumonia. diagnostic errors due to low suspicion of aids. | three patients encountered in a single month had insidious development of atypical respiratory or systemic symptoms and were found to be hypoxemic. all had normal chest roentgenograms and were perplexing problems in diagnosis. on initial presentation, none had evidence of pulmonary infection or recognized clinical or social features that suggested acquired immunodeficiency syndrome (aids). all received corticosteroids for respiratory distress before the correct diagnosis was made, and all died r ... | 1987 | 3499294 |
| pentamidine aerosol in prophylaxis and treatment of murine pneumocystis carinii pneumonia. | the efficacy and tolerance of pentamidine aerosol were evaluated in the prophylaxis and therapy of murine pneumocystis carinii pneumonia. p. carinii pneumonia was induced in rats by corticosteroid immunosuppression. pentamidine was administered three times weekly via a bird micronebulizer. the actual amount of pentamidine inhaled was estimated by monitoring the ventilation of the rats during the aerosol administration. pentamidine levels in blood, lung, liver and kidney samples were determined b ... | 1987 | 3499116 |
| torsade de pointes during administration of pentamidine isethionate. | pentamidine isethionate is a diamidine compound used in the treatment of a number of parasitic diseases, notably pneumocystis carinii pneumonia. although cases of sudden death have been reported during the administration of pentamidine, there have been no reported cases in the literature of pentamidine-associated arrhythmias. reported in this study are two cases of torsade de pointes occurring during the prolonged administration of pentamidine. in addition, electrocardiographic changes of marked ... | 1987 | 3499072 |
| pneumocystis carinii pneumonia (pcp) in a hemophiliac with transfusion-acquired aids. | 1987 | 3498988 | |
| prophylaxis against pneumocystis carinii pneumonia in patients receiving azidothymidine. | 1987 | 3498898 | |
| trimethoprim-sulfamethoxazole. | the antimicrobial combination of trimethoprim and sulfamethoxazole is active in vitro against a variety of gram-positive and gram-negative bacteria. clinically, it is useful for treatment and prophylaxis of various infections of the genitourinary tract and certain infections of the respiratory and gastrointestinal tracts. trimethoprim-sulfamethoxazole by itself or in combination with other antimicrobial agents is indicated for most nocardia asteroides infections. it is the antimicrobial agent of ... | 1987 | 3498863 |
| pneumocystis carinii pneumonia therapy with 9-deazainosine in rats. | an inosine analog, 9-deazainosine, has previously been demonstrated to inhibit pneumocystis carinii in culture with wi-38 cells. the present study shows that it is also effective against pneumocystis carinii in immunosuppressed sprague-dawley rats with pneumocystis carinii pneumonia. after 8 wk of immunosuppression, rats that developed severe pneumocystis carinii pneumonia were treated with either 9-deazainosine or served as controls. after 15 days of therapy, animals were sacrificed and severit ... | 1987 | 3498606 |
| inhaled or reduced-dose intravenous pentamidine for pneumocystis carinii pneumonia. a pilot study. | study objective: to evaluate inhaled or reduced-dose intravenous pentamidine for the treatment of patients with mild pneumocystis carinii pneumonia. design: open, nonrandomized pilot study; measurement of pentamidine concentrations in plasma and bronchoalveolar lavage fluid. patients: of 22 men with mild p. carinii pneumonia (po2 greater than or equal to 55 mm hg), 15 (9 in the inhaled group and 6 in the intravenous group) received treatment for their first episode and 7 for a repeat episode. in ... | 1987 | 3498418 |
| pneumocystis carinii pneumonia--changing status. | 1987 | 3498350 | |
| [bronchoscopic detection of pneumocystis carinii pneumonia]. | 1987 | 3498114 | |
| [severe pneumopathy caused by pneumocystis carinii in chickenpox in a immunosuppressed adult]. | 1987 | 3497599 | |
| [intracerebral calcification in a patient with late-onset congenital rubella]. | a fourteen-week-old boy is described who was admitted with failure to thrive and an interstitial pneumonia caused by pneumocystis carinii infection. a late onset congenital rubella infection was diagnosed in combination with an immunodeficiency. the congenital rubella infection induced a chronic meningoencephalitis. further investigations revealed intracerebral calcifications on computerized tomography of the skull. the clinical symptoms of early and late onset congenital rubella syndrome are de ... | 1987 | 3497469 |
| radiographic resolution of pneumocystis carinii pneumonia in response to corticosteroid therapy. | systemic corticosteroid therapy alone was administered to a patient with pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome. substantial clinical improvement and almost complete chest radiographic resolution of parenchymal infiltrates occurred. because spontaneous resolution of p. carinii pneumonia is not known to occur, corticosteroid therapy most likely was responsible for the favorable response. given the high mortality associated with p. carinii infection i ... | 1987 | 3496819 |
| nonspecific interstitial pneumonitis in patients with aids: radiologic features. | chest radiographic abnormalities in patients with aids usually are associated with opportunistic infection or neoplasm. one hundred five patients with aids and clinical evidence of pneumonitis had chest radiographs and underwent bronchoscopy with bronchoalveolar lavage, transbronchial biopsy, or open-lung biopsy. chest radiographs were abnormal in 73 (70%). pneumocystis carinii pneumonia was identified at bronchoscopy or open-lung biopsy in 52 (50%). nonspecific interstitial pneumonitis occurrin ... | 1987 | 3496748 |
| pneumocystis carinii pneumonia. | 1987 | 3496671 | |
| pneumocystis carinii infections in patients with aids. | 1987 | 3496651 | |
| efficacy and complications of transthoracic needle biopsy of lung in patients with pneumocystis carinii pneumonia and aids. | transthoracic needle biopsy of lung was performed under fluoroscopic guidance in 16 patients with aids or suspected aids for diagnosing 18 episodes of possible p carinii infection. diagnostic information was obtained in 15 of 18 cases. p carinii (10) and other infections agents (5) were diagnosed by tnb. the complications were pneumothorax in 44% (17% requiring chest tube drainage) and minor hemoptysis in 11%. our incidence of pneumothorax following tnb in patients with diseases other than aids ... | 1987 | 3496467 |
| gallium-67 scans of the chest in patients with acquired immunodeficiency syndrome. | eighty-six [67ga]citrate chest scans were performed in 71 adult patients with the acquired immunodeficiency syndrome. forty-five of these patients also had kaposi's sarcoma. only 29 of 57 abnormal scans were correlated with abnormal chest radiographs. chest radiographs were negative for 27 scans and unavailable for one. several scan patterns were seen. diffusely increased lung uptake was seen most commonly with pneumocystis carinii pneumonia, but also other infections and noninfectious inflammat ... | 1987 | 3496432 |
| patterns of gallium-67 scintigraphy in patients with acquired immunodeficiency syndrome and the aids related complex. | thirty-two patients with aids related complex (arc) or acquired immunodeficiency syndrome (aids) underwent 67ga scans as part of their evaluation. three patterns of 67ga biodistribution were found: lymph node uptake alone; diffuse pulmonary uptake; normal scan. gallium-67 scans were useful in identifying clinically occult pneumocystis carinii pneumonia in seven of 15 patients with arc who were asymptomatic and had normal chest radiographs. gallium scans are a useful ancillary procedure in the ev ... | 1987 | 3496431 |
| a critical review of the use of open lung biopsy in the management of the oncologic patient with acute pulmonary infiltrates. | in a retrospective review, 28 open lung biopsies from 27 oncology patients with acute pulmonary infiltrates were evaluated. the operative complication rate was 28%, and the operative mortality 4%. infection caused 57% of the infiltrates (16 cases); 87% of the infections were secondary to either pneumocystis carinii or a viral infection. two patients had bacterial pneumonia. sixteen of these cases survived (37%). all but one survivor had pneumocystis carinii. a nonspecific pneumonitis either with ... | 1987 | 3496003 |
| [inhalation pneumonia presenting as a pneumocystis infection]. | a case of pneumocystis carinii pneumonia is presented. following presentation a chronic alveolitis was uncovered, which was due to ultimately repeated and prolonged inhalation of sweets containing gum arabic. the diagnosis was confirmed by a trans-bronchial biopsy and by chemical analysis of centrifugation of the alveolar lavage deposit. after cessation of the inhalation the progress was satisfactory both in terms of clinical status and lung function measurement. | 1987 | 3495833 |
| deterioration of kidney function by high doses of co-trimoxazole in man. | high doses of co-trimoxazole in a patient with pneumocystis carinii and impaired kidney function (creatinine clearance 10 ml/min) resulted in a declining renal clearance of the drug but did not affect the average creatinine clearance. the renal clearance of sulfamethoxazole and its metabolites 5-hydroxy-, n4-acetyl-, n4-acetyl-5-hydroxysulfamethoxazole decreased 80%, while the renal clearance of trimethoprim decreased 60%. the renal clearance of all compounds was evidently dependent on urine flo ... | 1987 | 3495779 |
| successful intermittent chemoprophylaxis for pneumocystis carinii pneumonitis. | we conducted a prospective, randomized clinical trial over a two-year period in patients with acute lymphocytic leukemia to assess the effectiveness of trimethoprim-sulfamethoxazole given on three consecutive days each week as compared with daily in the prevention of pneumocystis carinii pneumonitis. p. carinii pneumonitis did not develop in any of 92 patients receiving the drug daily (30,602 patient-days) or in any of 74 who received it three consecutive days a week (27,329 patient-days), where ... | 1987 | 3495732 |
| intralymphatic interleukin-2 treatment of a hemophiliac aids patient with defective interleukin-2 production. | to improve immune functions in an interleukin-2 (il-2) deficient hemophiliac aids patient suffering from severe pneumocystis carinii pneumonia, treatment with il-2 was started in addition to standard antimicrobial therapy. highly purified il-2 was administered subcutaneously and then repeatedly intralymphatically in a manner similar to pedal lymphography. no toxicity was observed. the patient temporarily improved clinically as well as with regard to immunological functions. particularly the in v ... | 1987 | 3495696 |
| freeze-fracture localization of filipin-sterol complexes in plasma- and cyto-membranes of pneumocystis carinii. | the polyene antibiotic, filipin, was used as the probe for demonstrating sterols in the freeze-fractured plasma- and cytomembranes of pneumocystis carinii. the distribution of filipin-sterol complexes was homogeneous on the plasma membrane throughout all developmental stages from trophozoite to cyst; however, the density of the complexes gradually decreased with the progress of development. in the trophozoite, the density of the complexes was 485 +/- 42/micron2 on the p face and 341 +/- 27/micro ... | 1987 | 3495660 |
| experimental pneumocystis carinii pneumonia in the ferret. | pneumocystis carinii pneumonia (pcp) was provoked in the ferret, mustela pulorius furo, by immunosuppression with daily long-term administration of cortisone acetate, 10-20 mg/kg subcutaneously for 9 to 10 weeks, microscopically p. carinii was observed in the lungs of all 11 treated animals: mild to moderate in five and extensive disease in six. the histopathological features of pcp in the ferret included interstitial pneumonitis, scant mononuclear cell alveolitis, with abundant cysts and tropho ... | 1987 | 3495285 |
| [pneumocystis carinii in male drug addicts: morphologic study of the parasite]. | this work describes the first case of acquired immuno-deficiency syndrome (aids) to be found in sardinia. the patient was an adult male drug-addict who died following a respiratory inadequacy due to bronchial pneumonia resulting from pneumocystis carinii (pcp). for diagnostic purposes the emphasis is laid on the importance of morphological research into the parasite, considering the lack of specific evidence regarding serological investigation. therefore, the various techniques of coloration are ... | 1986 | 3495279 |
| pneumocystis carinii pneumonia. | 1987 | 3495178 | |
| atypical distribution of pneumocystis carinii infiltrates during radiation therapy. | bilateral peripheral pulmonary infiltrates caused by pneumocystis carinii developed in a patient undergoing mediastinal irradiation after chemotherapy for hodgkin disease. the paramediastinal part of the lung included within the treatment port remained clear during the 2 1/2 weeks of radiation therapy. the distribution of the pneumocystis infiltrates was altered by the radiation, producing a pattern that is the "radiographic negative" of typical post-radiation therapy paramediastinal fibrosis. | 1987 | 3495020 |
| freeze-fracture studies on pneumocystis carinii. ii. fine structure of the trophozoite. | ultrastructure of the trophozoite of pneumocystis carinii was studied by the freeze-fracture technique. nuclei and cytoplasmic organelles such as the endoplasmic reticulum, mitochondria, cytoplasmic vacuoles and small round bodies were observed. the mean number of nuclear pores was 8 per micron 2, which is small compared with that reported for other human pathogenic protozoa. in general, the density of nuclear pores is considered to be related to the metabolic activity of the nucleus. this resul ... | 1987 | 3494990 |
| pneumocystis carinii pneumonitis, eosinophilia and hypogammaglobulinemia. | 1987 | 3494981 | |
| disseminated pneumocystis carinii infection in aids. | 1987 | 3494947 | |
| comparison of histologic and quantitative techniques in evaluation of therapy for experimental pneumocystis carinii pneumonia. | pneumocystis carinii pneumonia was induced in rats by the administration of corticosteroids, and histologic and quantitative techniques were compared in the evaluation of the severity of the disease and response to therapy. a highly significant correlation was found between the histologic score of the extent of alveolar involvement (the standard method of assessment) and the number of p. carinii cysts and nuclei in lung homogenates, lung weight, and lung weight/body weight ratio. clear differenc ... | 1987 | 3494426 |
| successful treatment with aerosolized pentamidine of pneumocystis carinii pneumonia in rats. | we examined both the therapeutic efficacy and tissue distribution of aerosolized pentamidine in immunosuppressed rats with pneumocystis carinii pneumonia. in rats immunosuppressed by 5 weeks of pretreatment with dexamethasone, a 2-week course of 5 mg of aerosolized pentamidine per kg per day, administered free or encapsulated in the drug carrier system (liposomes), eradicated p. carinii pneumonia in 75% of treated animals. at this dose, extrapulmonary drug uptake as measured by a sensitive high- ... | 1987 | 3494424 |
| [aids in a child with a lav/htlv-iii infected mother]. | the clinical course of aids in a child of a htlv iii virus infected drug addicted mother is reported. aged 7 month the baby died from pneumocystis carinii pneumonia. the clinical course prior to the final lethal infection was remarkably uneventful. immunological controls revealed strikingly high immunoglobulin values, whereas only minor changes of cellular immunity were observed. at birth the baby had htlv iii antibodies as her mother, which dropped during the course of the disease to borderline ... | 1986 | 3494349 |
| pneumocystis carinii pneumonia in johannesburg. | pneumocystis carinii pneumonia is today an opportunistic infection of major importance, occurring in immunosuppressed patients. twelve cases of p. carinii pneumonia were seen by the pulmonology unit in johannesburg between november 1984 and december 1985. the clinical presentation, laboratory and radiographic features, method of diagnosis, treatment, complications of therapy and outcome of these 12 cases are described. | 1987 | 3494316 |
| [pneumocystis carinii pneumonia in patients with aids]. | 1987 | 3494202 | |
| pneumocystis carinii choroiditis in a male homosexual with aids and disseminated pulmonary and extrapulmonary p. carinii infection. | 1987 | 3494199 | |
| defect in production of b cell differentiation factor-like activity by mononuclear cells from a boy with hypogammaglobulinemia. | the case history of a boy who presented at 6 mo of age with pneumocystis carinii pneumonia is described. hypogammaglobulinemia was detected. his t lymphocytes and b lymphocytes proliferated with mitogens but no immunoglobulin was secreted secondary to polyclonal stimulation with pokeweed mitogen. his peripheral blood mononuclear cells secreted interleukin 2 and b cell growth factor (bcgf) but failed to secrete detectable levels of b cell differentiation factor (bcdf). studies of his b lymphocyte ... | 1987 | 3494068 |
| evidence for destruction of lung tissues during pneumocystis carinii infection. | five cases of pneumocystis carinii infection with evidence of lung tissue destruction that occurred in patients with the acquired immunodeficiency syndrome were reviewed. none of the patients had a history of cigarette smoking, but all five had either cavitarylike lesions in the lungs or had pneumothorax at the time of presentation to the hospital. all patients had p carinii identified in specimens obtained either from bronchial washings or from open-lung biopsy. in four of the five patients, no ... | 1987 | 3493747 |
| serological study of pneumocystis carinii infection in the absence of immunosuppression. | serum samples from 145 children with no known immunosuppressive illness were examined by indirect immunofluorescence for antibody to pneumocystis carinii. positive antibody titres (greater than or equal to 1:8 dilution) were found in 69 children (48%). antibody could not be detected in the remaining children. previous studies have shown that at least 75% of children have antibodies to p. carinii by the age of 4 years. this study shows a lower percentage of children with detectable antibody. this ... | 1987 | 3493735 |
| unusual remission of pneumocystis carinii pneumonia in a patient with the acquired immune deficiency syndrome. | pneumocystis carinii is a well-recognized cause of pneumonia in patients with immune deficiency, and when untreated, mortality approaches 100 percent. although rare cases suggesting spontaneous recovery (usually accompanied by resolving immune deficiency) have been reported, spontaneous resolution of p. carinii pneumonia in patients with the acquired immune deficiency syndrome (aids) has not been described. a patient with aids in whom pneumocystis pneumonia developed and remitted without appropr ... | 1987 | 3493693 |
| pneumocystis carinii. taxonomy as viewed by electron microscopy. | pneumocystis carinii is an opportunistic unicellular organism that can cause serious pulmonary infection in immunosuppressed patients. the taxonomy and classification of p. carinii has not yet been settled. the authors present transmission and scanning electron microscopic (tem and sem) observations of tissue from two patients with pulmonary pneumocystis infections. the infectious organisms display marked variability in shape and size. they appear to divide by binary fission and lack motility or ... | 1987 | 3493682 |
| drug treatment of pneumonia due to pneumocystis carinii. | 1987 | 3493548 | |
| prognostic indicators in patients with the acquired immune deficiency syndrome (aids) and respiratory infection. | the records of 63 patients with acquired immune deficiency syndrome (aids) and respiratory infection comprising 78 hospitalizations over a 36-month period were reviewed to ascertain the etiology of the respiratory infection and to identify the factors influencing short-term survival. pneumocystis carinii pneumonia (pcp) was diagnosed on 56 occasions in 46 patients. fifty percent of patients with pcp died with respiratory failure; of these, all but 1 were diagnosed using fiber-optic bronchoscopy. ... | 1986 | 3493511 |
| [aids and pneumocystis carinii pneumonia]. | 1986 | 3493366 | |
| phospholipid profile of pneumocystis carinii and its interaction with alveolar type ii epithelial cells. | pneumocystis carinii is an obligate parasite of mammalian lungs, attaching to but not invading the alveolar epithelium. the alveolar air spaces are rich in phospholipids, which are secreted by steroid-responsive alveolar type ii epithelial cells. p. carinii isolated from rat lungs was found to contain the expected structural phospholipids as well as a large amount of firmly attached disaturated phosphatidylcholine, the characteristic phospholipid of alveolar surfactant. in vitro, p. carinii cell ... | 1987 | 3493222 |
| disseminated pneumocystis carinii infection in a patient with acquired immunodeficiency syndrome. | pneumocystis carinii, a frequent cause of pneumonia in immunocompromised patients, rarely disseminates to involve other organs. this report describes a patient with acquired immunodeficiency syndrome and pneumocystis pneumonia in whom extrapulmonary p. carinii infection was diagnosed on duodenal and esophageal endoscopic biopsy specimens. autopsy revealed dissemination to multiple organs. | 1987 | 3493199 |
| endobronchial pneumocystis carinii infection in a patient with the acquired immune deficiency syndrome. | we report a case of endobronchial pneumocystis carinii infection in a patient who most likely had the acquired immune deficiency syndrome (aids). although many unusual manifestations of pneumocystis pneumonia have been reported in patients with aids, this is the first case of p carinii presenting as an endobronchial mass. | 1987 | 3493122 |
| roentgenographic patterns of pneumocystis carinii pneumonia in 104 patients with aids. | we reviewed the initial and follow-up chest roentgenograms (cxr) of 104 patients with the acquired immune deficiency syndrome (aids) and pneumocystis carinii pneumonia (pcp) diagnosed between 1981 and 1985 in order to determine the relative frequencies of its various roentgenographic patterns. although a diffuse bilateral interstitial infiltrate is most common, it was concluded that unusual and atypical roentgenographic manifestations of pcp occur in aids. these include localized infiltrate, cys ... | 1987 | 3493117 |
| high-dose corticosteroids as adjunct therapy in severe pneumocystis carinii pneumonia. | three patients with severe pneumocystis carinii pneumonia and acquired immunodeficiency syndrome, not responding to specific therapy with trimethoprim/sulfamethoxazole, were treated with a 24-hour course of high-dose methylprednisolone. rapid improvements in the clinical status and the chest x-rays were detected. in two of the patients, in whom lung biopsy was performed before initiation of corticosteroids, an intense interstitial mononuclear cell infiltrate was seen. in the one patient who had ... | 1986 | 3493015 |
| role of bronchial brushings in aids with pneumocystis carinii pneumonia. | we evaluated the efficacy of bronchial brushings in detecting pneumocystis carinii pneumonia (pcp) in patients with aids. bronchial brushings were performed on 20 occasions in 15 patients. nine of the 20 bronchial brushings were performed through an endotracheal tube without using a bronchoscope. twelve of the 20 were positive for pneumocystis carinii and 8 were negative. the initial diagnostic yield was 84%, the overall sensitivity 86%, and the predictive value of a negative test was 75%. these ... | 1986 | 3493014 |
| trimethoprim-sulfamethoxazole or pentamidine for pneumocystis carinii pneumonia. | 1987 | 3492953 |