Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| immunization with a momp-based vaccine protects mice against a pulmonary chlamydia challenge and identifies a disconnection between infection and pathology. | chlamydia pneumoniae is responsible for up to 20% of community acquired pneumonia and can exacerbate chronic inflammatory diseases. as the majority of infections are either mild or asymptomatic, a vaccine is recognized to have the greatest potential to reduce infection and disease prevalence. using the c. muridarum mouse model of infection, we immunized animals via the intranasal (in), sublingual (sl) or transcutaneous (tc) routes, with recombinant chlamydial major outer membrane protein (momp) ... | 2013 | 23613984 |
| detection of chlamydia and complement factors in neovascular membranes of patients with age-related macular degeneration. | to investigate whether chlamydia pneumoniae and complement factors were present in surgically removed choroidal neovascular membranes (cnv) of patients with age-related macular degeneration (amd). | 2013 | 23590149 |
| endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs. | apoptosis of endothelial cells (ecs) has been suggested to play a role in atherosclerosis. we studied the synergism of hypercholesterolemia with chlamydia pneumoniae and influenza virus infections on ec morphology and intimal changes in a minipig model. the coronary artery was excised at euthanasia (19 weeks of age) and serial sections were processed for the detection of ec apoptosis, histology, and transmission electron microscopy (tem) studies. there was a significantly higher number of tunel- ... | 2013 | 23580230 |
| microbiological diagnosis and antibiotic therapy in patients with community-acquired pneumonia and acute copd exacerbation in daily clinical practice: comparison to current guidelines. | the aim of this secondary analysis was to evaluate current microbiological approaches, microbiology, and antibiotic therapy in patients with community-acquired pneumonia (cap) and acute exacerbation of chronic obstructive pulmonary disease (aecopd) in clinical practice and to compare them with current international guidelines. | 2013 | 23564195 |
| buerger disease, smoking, and periodontitis. | weak oral bacteria such as periodontal bacteria or chlamydia pneumoniae have been observed in various arterial and venous lesions with epidemiological data reported prior to the discovery of bacterial invasion into vessels. rich lymph vessels easily bring the bacteria from the mouth to the neck and the venous angle, which is directly open to the blood vessels. periodontal bacteria travel within platelets and chlamydia pneumoniae can be carried by monocytes. the transportation system of other wea ... | 2008 | 23555343 |
| application of three uniplex polymerase chain reaction assays for the detection of atypical bacteria in asthmatic patients in kuwait. | respiratory infections are known to exacerbate wheezing in many asthmatic patients. we aimed to use molecular methods for the fast detection of mycoplasma pneumoniae, chlamydia pneumoniae and legionella pneumophila in respiratory specimens from asthmatic patients in kuwait. | 2013 | 23537827 |
| differential identification of atypical pneumonia pathogens in aorta and internal mammary artery related to ankle brachial index and walking distance. | we studied the existence of agents in aorta biopsies, such as chlamydia pneumoniae, cytomegalovirus, and mycoplasma pneumoniae, that are thought to have a role in atherosclerosis etiopathogenesis role, and their association with peripheral artery disease. | 2013 | 23535111 |
| infectious burden and cognitive function: the northern manhattan study. | we hypothesized that infectious burden (ib), a composite serologic measure of exposure to common pathogens (i.e., chlamydia pneumoniae, helicobacter pylori, cytomegalovirus, and herpes simplex virus 1 and 2) associated with vascular risk in the prospective northern manhattan study (nomas), would also be associated with cognition. | 2013 | 23530151 |
| abc transporter atpase of chlamydophila pneumoniae as a potential vaccine candidate. | better vaccines and new therapeutic drugs could be a successful breakthrough against intracellular bacteria. m. tuberculosis abc transporter atpase (rv0986) plays a role in mycobacterial virulence by inhibiting phagosome-lysosome fusion. thus, it could be a potential vaccine candidate. c. pneumoniae another important intracellular bacterium possesses a protein named cpb0255, which is homologous with the mycobacterial rv0986. the aim of this study was the cloning, over-expression and purification ... | 2013 | 23529295 |
| bias in associations of emerging biomarkers with cardiovascular disease. | numerous cardiovascular biomarkers are proposed as potential predictors of cardiovascular risk. | 2013 | 23529078 |
| recent advances in understanding the biology, epidemiology and control of chlamydial infections in koalas. | the koala (phascolarctos cinereus) is recognised as a threatened wildlife species in various parts of australia. a major contributing factor to the decline and long-term viability of affected populations is disease caused by the obligate intracellular bacteria, chlamydia. two chlamydial species infect the koala, chlamydia pecorum and chlamydia pneumoniae, and have been reported in nearly all mainland koala populations. chlamydial infections of koalas are associated with ocular infections leading ... | 2013 | 23523170 |
| could past chlamydial vascular infection promote the dissemination of chlamydia pneumoniae to the brain? | chlamydia pneumoniae, a pathogen responsible for respiratory tract infections, has been associated with atherosclerosis which, along with hypertension, hyperlipidemia, cardiovascular and/or cerebrovascular ischemia and stroke, is a risk factor for chronic neurological disorders. several studies have demonstrated the ability of c. pneumoniae to disseminate from lungs to arteries through peripheral blood mononuclear cells. once inside the vascular tissue, c. pneumoniae infection may disseminate vi ... | 2013 | 23489695 |
| prevalence of chlamydophila pneumoniae antibodies in women with pre-eclampsia in lagos, nigeria. | the precise aetiology of pre-eclampsia has remained unknown. it is still a major contributor to maternal and perinatal morbidity and mortality. | 2012 | 23468028 |
| association between intracellular infectious agents and schizophrenia. | a number of studies have reported association between toxoplasma gondii (t. gondii) and chlamydia infection and the risk of schizophrenia. the aim of the present study was to compare the prevalence of t. gondii and chlamydia infection between the schizophrenia and normal control subjects and to compare the clinical features between seropositive and seronegative schizophrenia patients. | 2012 | 23430959 |
| bacterial signatures in thrombus aspirates of patients with myocardial infarction. | infectious agents, especially bacteria and their components originating from the oral cavity or respiratory tract, have been suggested to contribute to inflammation in the coronary plaque, leading to rupture and the subsequent development of coronary thrombus. we aimed to measure bacterial dna in thrombus aspirates of patients with st-segment-elevation myocardial infarction and to check for a possible association between bacteria findings and oral pathology in the same cohort. | 2013 | 23418311 |
| impact of infectious etiology on the outcome of taiwanese patients hospitalized with community acquired pneumonia. | this study aimed to assess the relationships between infectious etiology, empiric treatment, and outcomes in taiwanese patients with community acquired pneumonia (cap). | 2013 | 23416657 |
| chronic lyme disease and co-infections: differential diagnosis. | in lyme disease concurrent infections frequently occur. the clinical and pathological impact of co-infections was first recognized in the 1990th, i.e. approximately ten years after the discovery of lyme disease. their pathological synergism can exacerbate lyme disease or induce similar disease manifestations. co-infecting agents can be transmitted together with borrelia burgdorferi by tick bite resulting in multiple infections but a fraction of co-infections occur independently of tick bite. cli ... | 2012 | 23400696 |
| [contemporary risks of infections by mycoplasma pneumoniae and chlamydophila pneumoniae]. | atypical microorganisms, like mycoplasma pneumoniae and chlamydophila pneumoniae are common subject of studies because of caused diseases. in the last years, attention is paid on serious complications, which persistent infection of this atypical pathogens can cause and on the immunological body answer for them. | 2012 | 23394038 |
| [role of infection in the pathogenesis of obesity]. | current global epidemic of obesity is mainly related to increased consumption of high energy density foods and sedentary lifestyle that leads to a positive energy balance with subsequent accumulation of fat stores, primarily in genetically predisposed individuals. however, additional pathogenetic factors should be considered, including an infection. several viruses causing obesity have been described in mice, chicken, rats, hamsters and monkeys. in humans, a significant positive association betw ... | 2012 | 23387813 |
| chlamydophila pneumoniae re-infection triggers the production of il-17a and il-17e, important regulators of airway inflammation. | investigation of the effects of interleukin (il)-17 cytokines in chlamydophila pneumoniae-infected mice. | 2013 | 23385305 |
| molecular cartography in acute chlamydia pneumoniae infections--a non-targeted metabolomics approach. | infections with chlamydia pneumoniae cause several respiratory diseases, such as community-acquired pneumonia, bronchitis or sinusitis. here, we present an integrated non-targeted metabolomics analysis applying ultra-high-resolution mass spectrometry and ultra-performance liquid chromatography mass spectrometry to determine metabolite alterations in c. pneumoniae-infected hep-2 cells. most important permutations are elaborated using uni- and multivariate statistical analysis, logd retention time ... | 2013 | 23354577 |
| community-acquired pneumonia. | community-acquired pneumonia (cap) is one of the most common acute infections requiring admission to hospital. the main causative pathogens of cap are streptococcus pneumoniae, influenza a, mycoplasma pneumoniae and chlamydophila pneumoniae, and the dominant risk factors are age, smoking and comorbidities. the incidence of cap and its common complications, such as the requirement for intensive care and complicated parapneumonic effusions, are increasing, making it essential for all physicians to ... | 2012 | 23342408 |
| [spectrum of pathogens for community-acquired pneumonia in children]. | to investigate the spectrum of pathogens for community-acquired pneumonia (cap) in children, and to provide a basis for the diagnosis and treatment of cap. | 2013 | 23336167 |
| two-step bacterial broad-range polymerase chain reaction analysis of heart valve tissue improves bacteriological diagnosis of infective endocarditis. | positive heart valve (hv) culture is a major duke's criterion for the diagnosis of infective endocarditis but is poorly sensitive. two broad-range 16s rdna polymerase chain reaction (pcr) methods were applied to 31 hv samples: first, a real-time method, then conventional end-point pcr was applied to hv samples on which the first pcr was negative. five specific real-time pcr procedures were also used in order to identify bartonella spp., tropheryma whipplei, chlamydophila pneumoniae, mycoplasma p ... | 2013 | 23318112 |
| neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage chlamydia pneumoniae replication by modulating intracellular iron homeostasis. | neutrophil gelatinase-associated lipocalin (ngal/lipocalin-2/lcn-2) is a 25kda protein which is involved in host defence against certain gram negative bacteria upon binding of iron loaded bacterial siderophores thereby limiting the availability of this essential nutrient to bacteria resulting in inhibition of their growth and pathogenicity. as iron is important for the growth of the intracellular bacterium chlamydia pneumoniae we questioned whether lcn-2 affects the course of this infection. we ... | 2012 | 23317919 |
| [the dynamics of detection of antibodies class g against chlamydia pneumoniae and chlamydia psittaci in blood serum of patients of different age groups]. | the detection of antibodies class g in blood serum of patients of different age groups was carried out in 2005-2010. the analysis permitted to establish the peak of activity of chlamydiae infection in 2006 and increase of activity of morbidity in 2010. | 2012 | 23305020 |
| chlamydia pneumoniae impairs the innate immune response in infected epithelial cells by targeting traf3. | type i ifns are induced during microbial infections and have well-characterized antiviral activities. traf3 is a signaling molecule crucial for type i ifn production and, therefore, represents a potential target for disarming immune responses. chlamydia pneumoniae is a human pathogen that primarily infects respiratory epithelial cells; the onset of symptoms takes several weeks, and the course of infection is protracted. c. pneumoniae has also been associated with a variety of chronic inflammator ... | 2013 | 23303668 |
| chlamydophila pneumoniae endonuclease iv prefers to remove mismatched 3' ribonucleotides: implication in proofreading mismatched 3'-terminal nucleotides in short-patch repair synthesis. | dna polymerase i (dnapoli) catalyzes dna synthesis during okazaki fragment maturation, base excision repair, and nucleotide excision repair. some bacterial dnapolis are deficient in 3'-5' exonuclease, which is required for removing an incorrectly incorporated 3'-terminal nucleotide during dna elongation by dna polymerase activity. the key amino acid residues in the exonuclease center of chlamydophila pneumoniae dnapoli (cpdnapoli) are naturally mutated, resulting in the loss of 3'-5' exonuclease ... | 2013 | 23291401 |
| [correlation between chlamydia pneumoniae infection and chronic obstructive pulmonary disease]. | to investigate the correlation between chlamydia pneumonia (cpn) infection and chronic obstructive pulmonary disease (copd). | 2012 | 23290855 |
| chlamydia pneumoniae and progression of subclinical atherosclerosis. | cross-sectional investigation between presence of antibodies and coronary artery calcification (cac) in past studies has shown no relationship, but progression over time has not been investigated. the objective of this study was to determine the relationship between presence of chlamydia pneumoniae antibodies and progression of cac and ankle-brachial index (abi). | 2014 | 23253746 |
| the incidence and etiology of community-acquired pneumonia in fever outpatients. | the purpose of this study was to analyze the incidence, etiology and clinical characteristics of community-acquired pneumonia (cap) among outpatients with sore throat and/or cough, and thus to provide theoretical basis for timely and accurate diagnosis and treatment for cap. we used chest x-rays for fever (a temperature greater than 37.5°c) patients, who were recruited since 2007, presenting with sore throat and/or cough. the patients' age, gender, days of fever, respiratory symptoms (e.g. cough ... | 2012 | 23239436 |
| development and evaluation of a mab-based elisa for detection of chlamydophila pneumoniae infection with variable domain 2 and 3 of the major outer membrane protein. | this paper aims to develop a monoclonal antibodies (mabs)- based elisa for detecting chlamydophila pneumoniae (c. pneumoniae) antigens in humans with the variable domains (vd) 2 and 3 of the major outer membrane protein (mompvd2-vd3) and to assess its sensitivity and specificity by comparing with a widely used mab that is able to recognize the elementary bodies of c. pneumoniae. | 2012 | 23228839 |
| chlamydia pneumoniae: modern insights into an ancient pathogen. | chlamydia pneumoniae is an enigmatic human and animal pathogen. originally discovered in association with acute human respiratory disease, it is now associated with a remarkably wide range of chronic diseases as well as having a cosmopolitan distribution within the animal kingdom. molecular typing studies suggest that animal strains are ancestral to human strains and that c. pneumoniae crossed from animals to humans as the result of at least one relatively recent zoonotic event. whole genome ana ... | 2013 | 23218799 |
| role of atypical pathogens in nursing home-acquired pneumonia. | no international consensus has been reached on the empirical use of antibiotics with atypical coverage in nursing home-acquired pneumonia (nhap). aspiration is an important cause of nhap, but it may not require antimicrobial treatment. this study aimed to investigate the prevalence and clinical characteristics of ap infections and review the need for empirical antibiotics with atypical coverage in nhap. | 2013 | 23206723 |
| chlamydia pneumoniae infection acts as an endothelial stressor with the potential to initiate the earliest heat shock protein 60-dependent inflammatory stage of atherosclerosis. | we identified increased expression and redistribution of the intracellular protein 60-kda human heat shock protein (hhsp60) (hspd1) to the cell surface in human endothelial cells subjected to classical atherosclerosis risk factors and subsequent immunologic cross-reactivity against this highly conserved molecule, as key events occurring early in the process of atherosclerosis. the present study aimed at investigating the role of infectious pathogens as stress factors for vascular endothelial cel ... | 2013 | 23192457 |
| prospective detection of respiratory pathogens in symptomatic children with cancer. | : the data on human rhinovirus, coronavirus, bocavirus, metapneumovirus, chlamydophila pneumoniae, mycoplasma pneumoniae and bordetella pertussis infections in children with cancer is limited. | 2013 | 23190778 |
| [investigation of bacterial etiology with conventional and multiplex pcr methods in adult patients with community-acquired pneumonia]. | community-acquired pneumonia (cap) is still a serious life-threatening disease, in which the etiologic agent cannot be identified in more than 50% of patients despite advanced diagnostic methods. the most commonly used methods in the determination of cap etiology are culture and serological tests. since early and accurate therapy reduces the mortality in cap cases, rapid and reliable diagnostic methods are needed. the aim of this study was to determine the bacterial etiology in adult patients wi ... | 2012 | 23188566 |
| chlamydophila pneumoniae in human immortal jurkat cells and primary lymphocytes uncontrolled by interferon-γ. | lymphocytes are a potential host cell for chlamydophila pneumoniae, although why the bacteria must hide in lymphocytes remains unknown. meanwhile, interferon (ifn)-γ is a crucial factor for eliminating chlamydiae from infected cells through indoleamine 2,3-dioxygenase (ido) expression, resulting in depletion of tryptophan. we therefore assessed if lymphocytes could work as a shelter for the bacteria to escape ifn-γ. c. pneumoniae grew normally in human lymphoid jurkat cells, even in the presence ... | 2013 | 23178757 |
| one-year observation of inflammatory markers in patients with aortic valve stenosis who expressed high or low chlamydia pneumoniae antibody titers. | aortic valve stenosis (avs) and atherosclerosis can be regarded as two manifestations of the same pathological process. the study aim was to evaluate annually the plasma levels of c-reactive protein (crp), interleukin-6 (il-6) and tumor necrosis factor alpha (tnfalpha) in avs patients, and to compare these data in avs patients with and without high igg, igm, and iga titers against chlamydia pneumoniae. | 2012 | 23167224 |
| chlamydia pneumoniae modulates human monocyte-derived dendritic cells functions driving the induction of a type 1/type 17 inflammatory response. | chlamydia pneumoniae is a respiratory pathogen involved in the onset of chronic inflammatory pathologies. dendritic cells (dc), are major players in spreading of c. pneumoniae from the lungs, a crucial step leading to disseminated infections. less is known concerning modulation of dc functions consequent to encounter with the bacterium. in order to address this aspect, human monocyte-derived (md)dc were infected with c. pneumoniae. after internalization bacterial counts increased in mddc, as wel ... | 2013 | 23164610 |
| transcription factor complex ap-1 mediates inflammation initiated by chlamydia pneumoniae infection. | chlamydia pneumoniae is responsible for a high prevalence of respiratory infections worldwide and has been implicated in atherosclerosis. inflammation is regulated by transcription factor (tf) networks. yet, the core tf network triggered by chlamydiae remains largely unknown. primary human coronary artery endothelial cells were mock-infected or infected with c. pneumoniae to generate human transcriptome data throughout the chlamydial developmental cycle. using systems network analysis, the predo ... | 2013 | 23163821 |
| [role of infectious agents in the emergence of malignant tumors]. | according to the data of the international agency for research on cancer (iarc), at least 6 virus species (hpv, ebv, hhv-8/kshv, htlv-1, hbv, hcv), 4 helminthes species (schistosoma haematobium and japonicum, opisthorchis viverrini, clonorchis sinensis) and i bacterium species (helicobacter pylori) have been proved to be capable of causing the development of cancer. the analysis of the data available shows that merkel cell polyomavirus (mcv), herpes simplex virus (hsv), john cunningham polyomavi ... | 2012 | 23163048 |
| [study of prevalence of rare and difficult to cultivate causative agents of inflammatory diseases of respiratory organs]. | study the prevalence of mycoplasma pneumoniae, chlamydophila pneumoniae, chlamydophila psittaci, legionella pneumophila, moraxella catarrhalis, cytomegalovirus, herpes simplex i/ii virus (hsv i/ii) in individuals of various age groups with varying inflammatory broncho-pulmonary diseases. | 2012 | 23163026 |
| chlamydia pneumoniae and osteoporosis-associated bone loss: a new risk factor? | we found an association between the presence of chlamydia pneumoniae dna both in osteoporotic bone tissue and peripheral blood mononuclear cells (pbmcs) and the increase in circulating resorptive cytokines. | 2013 | 23160916 |
| construction of a highly flexible and comprehensive gene collection representing the orfeome of the human pathogen chlamydia pneumoniae. | the gram-negative bacterium chlamydia pneumoniae (cpn) is the leading intracellular human pathogen responsible for respiratory infections such as pneumonia and bronchitis. basic and applied research in pathogen biology, especially the elaboration of new mechanism-based anti-pathogen strategies, target discovery and drug development, rely heavily on the availability of the entire set of pathogen open reading frames, the orfeome. the orfeome of cpn will enable genome- and proteome-wide systematic ... | 2012 | 23157390 |
| antibody to epstein-barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset. | a defined diagnostic panel differentiated patients who had been diagnosed with chronic fatigue syndrome (cfs), based upon fukuda/carruthers criteria. this diagnostic panel identified an epstein-barr virus (ebv) subset of patients (6), excluding for the first time other similar "clinical" conditions such as cytomegalovirus (cmv), human herpesvirus 6 (hhv6), babesiosis, ehrlichiosis, borreliosis, mycoplasma pneumoniae, chlamydia pneumoniae, and adult rheumatic fever, which may be mistakenly called ... | 2012 | 23155374 |
| genetic and infectious profiles of japanese multiple sclerosis patients. | nationwide surveys conducted in japan over the past thirty years have revealed a four-fold increase in the estimated number of multiple sclerosis (ms) patients, a decrease in the age at onset, and successive increases in patients with conventional ms, which shows an involvement of multiple sites in the central nervous system, including the cerebrum and cerebellum. we aimed to clarify whether genetic and infectious backgrounds correlate to distinct disease phenotypes of ms in japanese patients. | 2012 | 23152786 |
| bacteria associated with acute exacerbations of chronic obstructive pulmonary disease requiring mechanical ventilation and antimicrobial management in respiratory care unit of central chest institute of thailand. | to investigate the role of bacterial infection, antimicrobial sensitivity and antibiotics usage in severe acute exacerbations of copd requiring mechanical ventilation in the respiratory care unit of the central chest institute of thailand. | 2012 | 23130469 |
| plasmacytoid dendritic cells play a role for effective innate immune responses during chlamydia pneumoniae infection in mice. | plasmacytoid dendritic cells (pdcs) are known for their robust antiviral response and their pro-tolerance effects towards allergic diseases and tissue engraftments. however, little is known about the role pdcs may play during a bacterial infection, including pulmonary chlamydia pneumoniae (cp). in this study, we investigated the role of pdcs during pulmonary cp infection. our results revealed that depletion of pdcs during acute cp infection in mice results in delayed and reduced lung inflammatio ... | 2012 | 23119083 |
| rapid detection of atypical respiratory bacterial pathogens by real-time pcr. | the accurate diagnosis of lower respiratory tract infection remains a challenge, with conventional diagnostic methods often failing to identify a causative agent. here we describe a multiplex real-time pcr assay that has been validated for the detection of the rarely identified atypical bacterial pathogens: legionella pneumophila, mycoplasma pneumoniae, and chlamydophila pneumoniae. due to the complexity and poor performance of the existing cultural and serological methods for the detection of t ... | 2013 | 23104286 |
| evaluation of serological tests for diagnosis of chlamydophila pneumoniae pneumonia in patients with nursing and healthcare-associated pneumonia. | nursing and healthcare-associated pneumonia (nhcap) is a new category that is distinct from community-acquired pneumonia that has been documented in the 2011 japanese respiratory society (jrs) guidelines. we aimed to evaluate an elnas plate test for detecting anti-chlamydophila pneumoniae-specific immunoglobulin m (igm) antibodies in patients with nhcap, by comparing the results of the elnas test with those of the hitazyme enzyme-linked immunosorbent assay (hitazyme-elisa) and those of immunoblo ... | 2013 | 23096022 |
| chlamydophila pneumoniae serology: cross-reaction with mycoplasma pneumoniae infection. | atypical pathogens mycoplasma pneumoniae and chlamydophila pneumoniae play an important role in community-acquired pneumonia. however, it has been pointed out that positive enzyme-linked immunosorbent assay (elisa, hitazyme c. pneumoniae) igm reactivity is frequent among m. pneumoniae pneumonia patients. to clarify the reactivity of elisa igm in m. pneumoniae pneumonia, findings were compared with immunoblotting, elnas plate c. pneumoniae (elnas) and the micro-immunofluorescence (mif) test. nine ... | 2013 | 23065148 |
| evidence for chlamydia in wild mammals of the serengeti. | only limited information is available on the presence of chlamydiaceae in wildlife, a deficit that is particularly acute concerning mammalian wildlife in africa. in a retrospective analysis of organ material from an earlier study on wild mammals from the seregenti national park, 521 samples from 54 animals of 14 mammalian species were investigated. the presence of chlamydiaceae was analyzed using molecular methods and immunohistochemistry. chlamydial dna was detected by real-time polymerase chai ... | 2012 | 23060512 |
| seroprevalence of chlamydophila pneumoniae in hiv-infected children in vietnam. | a total of 89 blood samples collected from hiv-infected infants and children from provinces of southern vietnam who were hospitalized at children's hospital 1, ho chi minh city, during the 1-year period from october 2004 to september 2005 were submitted to serological screening for igg, iga, and igm antibodies against chlamydophila pneumoniae (c. pneumoniae). the presence of this microorganism was also evaluated by pcr. the results showed that 64 % of the samples were positive for anti-c. pneumo ... | 2013 | 23053502 |
| immunoglobulin-specific responses to chlamydia elementary bodies in individuals with and at risk for genital chlamydial infection. | renewed interest in chlamydia vaccination has revealed the need for a greater understanding of the seroprevalence of chlamydial infection in us populations. we used a chlamydia trachomatis elementary body (eb)-based enzyme-linked immunosorbent assay to define the characteristics of the humoral immune response and to determine seroprevalence. two groups were analyzed: one consisting of patients with current, laboratory confirmed, genital chlamydial infection (n = 98) and one group of individuals ... | 2012 | 23045619 |
| characterization of the activity and expression of arginine decarboxylase in human and animal chlamydia pathogens. | chlamydia pneumoniae encodes a functional arginine decarboxylase (argdc), aaxb, that activates upon self-cleavage and converts l-arginine to agmatine. in contrast, most chlamydia trachomatis serovars carry a missense or nonsense mutation in aaxb abrogating activity. the g115r missense mutation was not predicted to impact aaxb functionality, making it unclear whether aaxb variations in other chlamydia species also result in enzyme inactivation. to address the impact of gene polymorphism on functi ... | 2012 | 23043454 |
| distinct genetic and infectious profiles in japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status. | to clarify whether genetic and common infectious backgrounds are distinct, according to anti-aquaporin 4 (aqp4) antibody status in japanese patients with neuromyelitis optica (nmo). | 2013 | 23038741 |
| hepatitis c virus infection and risk of coronary artery disease: a systematic review of the literature. | several chronic infections have been associated with cardiovascular diseases, including chlamydia pneumoniae, human immunodeficiency virus and viral hepatitis. this review evaluates the literature on the association between chronic hepatitis c virus (hcv) infection and the risk of coronary artery disease (cad). | 2012 | 23031062 |
| atherosclerosis and infection: is the jury still not in? | atherosclerosis is a chronic inflammatory process accounting for increased cardiovascular and cerebrovascular morbidity and mortality. a wealth of recent data has implicated several infectious agents, mainly chlamydophila pneumoniae, helicobacter pylori, cmv and periodontal pathogens, in atherosclerosis. thus, we sought to comprehensively review the available data on the topic, exploring in particular the pathogenetic mechanisms, and discuss anticipated future directions. | 2012 | 23030426 |
| infections and atheromatous plaque: current therapeutic implications. | infections are the most common inflammatory triggers and acute and chronic infections have been associated with the development and progression of atherosclerotic disease raising interest in the infectious hypothesis of atherosclerosis. pathogens have been identified in atherosclerotic plaques and large epidemiological studies have documented conflicting associations between serological evidence of infection and cardiovascular events. influenza a was mostly studied as a trigger for cardiovascula ... | 2013 | 23016720 |
| host cell golgi anti-apoptotic protein (gaap) and growth of chlamydia pneumoniae. | chlamydia pneumoniae protein cpn0809 is a type three secretion system substrate, the exact function of which in infection pathogenesis has remained unknown. in this study, we identified by yeast two-hybrid screening a potential host cell interaction partner of cpn0809, golgi anti-apoptotic protein (gaap), a conserved protein found in eukaryotic cells. gaap gene is expressed at relatively constant levels and its expression remained stable also after c. pneumoniae infection. the interaction betwee ... | 2013 | 23000903 |
| toll-like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma. | airway inflammation in asthma involves innate immune responses. toll-like receptors (tlrs) and thymic stromal lymphopoietin (tslp) are thought to be involved in airway inflammation, but their expression in asthmatics' both large and small airways has not been investigated. | 2012 | 22994343 |
| immunogenicity of cpn0425 and its localization in cells infected with chlamydophila pneumoniae. | the present study aimed to determine the intracellular localization of cpn0425 in chlamydophila pneumoniae-infected cells. the recombinant plasmid pgex-6p/cpn0425 was transformed into e.coli bl21 cells to express the fusion protein. following purification with glutathione s-transferase (gst) resin chromatography, the cpn0425 fusion protein was used to induce immunity in mice to develop monoclonal and polyclonal antibodies, which were subsequently used to localize the endogenous cpn0425 protein b ... | 2012 | 22992790 |
| skin own bacteria may aggravate inflammatory and occlusive changes in atherosclerotic arteries of lower limbs. | seroepidemiological studies have given rise to the hypothesis that microorganisms like chlamydia pneumoniae (cp), helicobacter pylori (hp), cytomegalovirus (cmv), hcv types 1 and 2, and bacteria involved in dental or other unspecified infection sites may initiate or maintain the atherosclerotic process in lower limb arteries. however, not much attention has been attached to the patient's own limb skin and deep tissues bacterial flora, activated in ischemic tissues. this flora may enhance the inf ... | 2012 | 22990511 |
| innate immune responses to chlamydia pneumoniae infection: role of tlrs, nlrs, and the inflammasome. | chlamydiae are important human pathogens that are responsible for a wide rage of diseases with a significant impact on public health. in this review article we highlight how recent studies have increased our knowledge of chlamydia pneumoniae pathogenesis and mechanisms of innate immunity directed host defense against c. pneumoniae infection. | 2012 | 22985781 |
| co-infection with invasive pulmonary aspergillosis and pneumocystis jirovecii pneumonia after corticosteroid therapy. | a 95-year-old man with chronic obstructive pulmonary disease and chronic hepatitis c virus infection was treated for acute lung injury caused by chlamydophila pneumoniae with antibiotics and high-dose corticosteroids. in total, 7,500 mg methylprednisolone and 680 mg prednisolone were administered over 21 days. however, respiratory failure progressed, and chest computed tomography (ct) scan showed bilateral ground-glass opacity and cavity-forming consolidation in the right upper lobe. despite int ... | 2013 | 22965844 |
| impact of multiple antigenic epitopes from apob100, hhsp60 and chlamydophila pneumoniae on atherosclerotic lesion development in apob(tm2sgy)ldlr(tm1her)j mice. | to assess whether immunizing apob(tm2sgy)ldlr(tm1her)j mice simultaneously with different atherosclerosis-related epitopes engineered in a single recombinant protein is effective in reducing atherosclerotic lesions. | 2012 | 22959702 |
| an experimental model for induction of lung cancer in rats by chlamydia pneumoniae. | to assess induction effects of chlamydia pneumoniae (cpn) on lung cancer in rats. | 2012 | 22938465 |
| etiology and antimicrobial resistance of community-acquired pneumonia in adult patients in china. | appropriate antimicrobial therapy of community-acquired pneumonia (cap) is mainly based on the distribution of etiology and antimicrobial resistance of major pathogens. we performed a prospective observational study of adult with cap in 36 hospitals in china. | 2012 | 22932165 |
| effect of the termini of rnase hs from chlamydophila pneumoniae on enzymatic biochemical characterization. | a difference between prokaryotic rnase hii and hiii, which both belong to type 2 rnase h, is a long n-terminal extension of hiii; however, the main-fold structures of hii and hiii known as rnase h-fold are similar. to further understand the structure-function relationship of rnase hii and rnase hiii, biochemical analyses were carried out using n-terminal truncations of rnase hiii (iiin56(δ), iiin81(δ), and iiin88(δ)) and c-terminal truncation (iic19(δ)) of rnase hii from chlamydophila pneumoniae ... | 2012 | 22908176 |
| groel1, from chlamydia pneumoniae, induces vascular adhesion molecule 1 expression by p37(auf1) in endothelial cells and hypercholesterolemic rabbit. | the expression of vascular adhesion molecule-1 (vcam-1) by endothelial cells may play a major role in atherogenesis. the actual mechanisms of chlamydia pneumoniae (c. pneumoniae) relate to atherogenesis are unclear. we investigate the influence of vcam-1 expression in the groel1 from c. pneumoniae-administered human coronary artery endothelial cells (hcaecs) and hypercholesterolemic rabbits. in this study, we constructed the recombinant groel1 from c. pneumoniae. the hcaecs/thp-1 adhesion assay, ... | 2012 | 22900050 |
| infectious agents and neurodegeneration. | a growing body of epidemiologic and experimental data point to chronic bacterial and viral infections as possible risk factors for neurodegenerative diseases, including alzheimer's disease, parkinson's disease and amyotrophic lateral sclerosis. infections of the central nervous system, especially those characterized by a chronic progressive course, may produce multiple damage in infected and neighbouring cells. the activation of inflammatory processes and host immune responses cause chronic dama ... | 2012 | 22899188 |
| dual-color bioluminescent assay using infected hepg2 cells sheds new light on chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7α-hydroxylase (cyp7a1) transcription. | chlamydia pneumoniae and human cytomegalovirus (hcmv) are intracellular pathogens able to infect hepatocytes, causing an increase in serum triglycerides and cholesterol levels due to the production of inflammatory cytokines. we investigated whether these pathogens could interfere with cholesterol metabolism by affecting activity of hepatic cholesterol 7α-hydroxylase (cyp7a1) promoter. cyp7a1 is the rate-limiting enzyme responsible for conversion of cholesterol to bile acids, which represents the ... | 2012 | 22889738 |
| chronic pharyngitis: role of atypical organisms: a case control study from south india. | bacteria including chlamydophila pneumoniae, mycoplasma pneumoniae, and anaerobic bacteria such as fusobacterium necrophorum have been implicated as etiological agents of chronic pharyngitis in western literature. because there are no data regarding this from india, the authors undertook this study. | 2012 | 22886080 |
| [relationship of cytomegalovirus, chlamydia pneumoniae and herpes simplex virus type 2 infections with preeclampsia]. | to explore the potential relationship of cytomegalovirus (cmv), chlamydia pneumoniae (cp) and herpes simplex virus type 2 (hsv-2) in inflammation and preeclampsia. | 2012 | 22883201 |
| chlamydia pneumoniae infection in adolescents with type 1 diabetes mellitus. | chlamydia pneumoniae, an intracellular bacterium, is associated with respiratory diseases, reinfectivity and chronic diseases such as cardiovascular disease, hypertension and stroke. the risk of infection is higher and infections are a serious clinical problem in patients with type 1 (insulin-dependent) diabetes mellitus (t1dm). although diabetes mellitus and hyperglycaemia are considered possible risk factors for various types of aetiological agents, the epidemiological evidence concerning c. p ... | 2012 | 22859582 |
| the adenoviral infections in children admitted to hospital with pneumonia, acute bronchiolitis or respiratory viral infections. | the objective of this study was to investigate the percent of infections with adenovirus (adv) in children who had pneumonia, acute bronchiolitis or viral respiratory infections and were admitted to two pediatrics hospitals in bucharest (grigore alexandrescu hospital and alfred rusescu hospital). | 2014 | 22838216 |
| chlamydophila (chlamydia) pneumoniae infection promotes vascular smooth muscle cell adhesion and migration through iq domain gtpase-activating protein 1. | the mechanisms for chlamydophila (chlamydia) pneumoniae (c. pneumoniae) infection-induced atherosclerosis are still unclear. cell adhesion has important roles in vascular smooth muscle cell (vsmc) migration required in the development of atherosclerosis. however, it is still unknown whether iq domain gtpase-activating protein 1 (iqgap1) plays pivotal roles in c. pneumoniae infection-induced the adhesion and migration of rat primary vsmcs. accordingly, in this study, we demonstrated that rat prim ... | 2012 | 22835851 |
| chlamydia pneumoniae infection presenting with angioedema in an adolescent. | 2012 | 22830550 | |
| [role of chlamydia trachomatis and chlamydophila pneumoniae in damage of eye posterior segment structures]. | study the ability of chlamydia trachomatis and chlamydophila pneumoniae to damage structures of eye posterior segment, features of development of such infectious process, its morphological and clinical characteristics. | 2012 | 22830280 |
| pathogen burden, cytomegalovirus infection and inflammatory markers in the risk of premature coronary artery disease in individuals of indian origin. | coronary artery disease (cad) occurs at an earlier age in south asians compared with other ethnic groups. infection and inflammation show a positive association with the disease. | 2012 | 22826649 |
| analysis of gene expression in penicillin g induced persistence of chlamydia pneumoniae. | chlamydia pneumoniae is responsible for respiratory tract infections and has been associated to chronic diseases such as atherosclerosis. the involvement of c. pneumoniae in chronic diseases may be correlated to its ability to induce persistent forms in which chlamydiae remain viable but are not cultivable. the aim of our study is to investigate c. pneumoniae specific gene activities associated with the development of chlamydial persistence in a cell culture system in the presence of penicillin ... | 2013 | 22824742 |
| predominant immunoreactivity of porphyromonas gingivalis heat shock protein in autoimmune diseases. | autoimmune diseases, including atherosclerosis, diabetes mellitus and rheumatoid arthritis, can be triggered and aggravated by the pathogen-driven antigenic peptide from porphyromonas gingivalis hsp60. p. gingivalis is the major pathogen of chronic periodontitis, which is a global epidemic prevalent in two-thirds of the adult population. the monoclonal antibody raised against peptide 19 (pep19: tlvvnrlrgslkicavkapg) from p. gingivalis hsp60 was polyreactive to the human homolog. the aim of this ... | 2012 | 22812430 |
| oral azithromycin in extended dosage schedule for chronic, subclinical chlamydia pneumoniae infection causing coronary artery disease: a probable cure in sight? results of a controlled preliminary trial. | two mega trials have raised the question as to whether the hypothesis that infection plays a role in atherosclerosis is still relevant. this controlled preliminary trial investigated an extended dose of azithromycin in the treatment of chlamydia pneumoniae infection causing coronary artery disease (cad). | 2012 | 22807637 |
| low-dose lipopolysaccharide pretreatment suppresses choroidal neovascularization via il-10 induction. | recent studies have suggested that some kinds of microbial infection may have a crucial role in the development of many diseases such as autoimmune diseases and certain types of cancer. it has been reported that some chronic infections, such as chlamydia pneumoniae, and immunological dysfunctions are associated with age-related macular degeneration (amd), a leading cause of blindness. to evaluate the association between systemic low-level inflammation induced by infection and amd pathogenesis, w ... | 2012 | 22802947 |
| [mixed infections in children with mycoplasma pneumoniae pneumonia]. | to investigate the incidence and clinical features of mixed infections in children with mycoplasma pneumoniae (mp) pneumonia. | 2012 | 22801206 |
| jurkat cell proliferation is suppressed by chlamydia (chlamydophila) pneumoniae infection accompanied with attenuation of phosphorylation at thr389 of host cellular p70s6k. | chlamydia (chlamydophila) pneumoniae infects t lymphocytes and multiplies within them. our previous studies have indicated that c. pneumoniae infection suppresses proliferation of peripheral blood mononuclear cells stimulated with staphylococcus-enterotoxin b; however, the mechanism of suppression was unclear. in this study, we explored the molecular mechanism involved in c. pneumoniae infection by using human acute t cell leukemia cell line, jurkat e6-1. proliferation of jurkat cells was suppre ... | 2013 | 22795649 |
| [community-acquired pneumonia: comparison of etiological diagnostic methods in clinical practice]. | comparison of different methods of community-acquired pneumonia (cap) etiological diagnosis. | 2012 | 22774484 |
| single tube real time pcr for detection of streptococcus pneumoniae, mycoplasma pneumoniae, chlamydophila pneumoniae and legionella pneumophila from clinical samples of cap. | we designed a multiplex real time pcr for rapid, sensitive and specific detection of streptococcus pneumoniae, legionella pneumophila, chlamydophila pneumoniae and mycoplasma pneumoniae. the study cases consisted of 129 patients with community acquired pneumonia (cap). bacteriological techniques were implemented for detection of the cultivable organisms. dna were extracted from sputa, throat swabs, bronchoalveolar lavages and tracheal aspirates and used as templates in real time pcr. the primers ... | 2012 | 22750778 |
| tlr2, but not tlr4, is required for effective host defence against chlamydia respiratory tract infection in early life. | chlamydia pneumoniae commonly causes respiratory tract infections in children, and epidemiological investigations strongly link infection to the pathogenesis of asthma. the immune system in early life is immature and may not respond appropriately to pathogens. toll-like receptor (tlr)2 and 4 are regarded as the primary pattern recognition receptors that sense bacteria, however their contribution to innate and adaptive immunity in early life remains poorly defined. we investigated the role of tlr ... | 2012 | 22724018 |
| the role of atypical pathogens in community-acquired pneumonia. | the term atypical pneumonia was first used in 1938, and by the 1970s it was widely used to refer to pneumonia due to mycoplasma pneumoniae, legionella pneumophila (or other legionella species), and chlamydophila pneumoniae. however, in the purest sense all pneumonias other than the classic bacterial pneumonias are atypical. currently many favor abolition of the term atypical pneumonia.this review categorizes atypical pneumonia pathogens as conventional ones; viral agents and emerging atypical pn ... | 2012 | 22718210 |
| [morphological factors of productive and persistent developmental cycles of chlamydia pneumoniae in human coronary and aortic endothelium]. | among 46 patients 39 died of cardial cause and 7--noncardial one. chlamydia pneumonia (ch-p) was founded out in aortal endothelium of 26 studied patients. only 3 patients (11%) had the typical form of inclusions, 23 cases (89% of infected patients) had persistent form of inclusions in aortal endothelium. 7 patients had persistent form of inclusions in coronary epithelium. an acute myocardial infarction was accompanied by ch-p (9 cases from 11). the productive form of ch-p developmental cycle was ... | 2012 | 22712301 |
| induction of vegf and mmp-9 expression by toll-like receptor 2/4 in human endothelial cells infected with chlamydia pneumoniae. | matrix metalloproteinases (mmp) are a family of host-derived enzymes involved in the turnover of extracellular matrix (ecm) molecules, and, in particular, it is demonstrated that the 92 kda gelatinase mmp-9 is often expressed in atherosclerotic plaques by macrophages and smooth muscle cells. recent evidence supports a role of toll-like receptor (tlr) signaling in the development of atherosclerosis lesions. in this study, we analyzed the tlr2/tlr4 expression in huvec infected with c. pneumoniae a ... | 2017 | 22697069 |
| conformation study of 2-arylbenzimidazoles as inhibitors of chlamydia pneumoniae growth. | chlamydia pneumoniae is a worldwide cause of various respiratory track diseases ranging from asymptomatic pharyngeal infection to severe, sometimes fatal pneumonia. we have previously identified 2-arylbenzimidazoles as highly active antichlamydial compounds. in this work the importance of conformational effects on the structure-activity relationship of these compounds was studied. to simplify calculations, properly substituted n-phenylbenzamides, or the corresponding heterocyclic compounds, and ... | 2012 | 22695128 |
| chlamydia pneumoniae infection associated with uncontrolled asthma: a hospital based cross sectional study. | to evaluate the proportion of anti- chlamydia pneumoniae (cp) igm positivity in patients with uncontrolled asthma and partly controlled childhood asthma and their clinical correlates. | 2012 | 22678519 |
| pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type iii secretion. | salicylidene acylhydrazides belong to a class of compounds shown to inhibit bacterial type iii secretion (t3s) in pathogenic gram-negative bacteria. this class of compounds also inhibits growth and replication of chlamydiae, strict intracellular bacteria that possess a t3s system. in this study a library of 58 salicylidene acylhydrazides was screened to identify inhibitors of chlamydia growth. compounds inhibiting growth of both chlamydia trachomatis and chlamydophila pneumoniae were tested for ... | 2012 | 22669447 |
| the infectious burden in atherothrombosis. | pathogenesis of atherosclerosis involves multiple mechanisms, including imbalanced lipid metabolism, disturbed equilibrium of the immune response, and chronic inflammation of the artery wall. several reports have shown a relationship between the development of atherosclerosis and the presence of infectious diseases, widely occurring in the general population, often chronic and/or asymptomatic. beyond chlamydia pneumoniae, a large number of infectious agents have been linked with an increased ris ... | 2012 | 22660918 |
| one-year observation of inflammatory markers in patients with aortic valve stenosis. | the study aim was to conduct an annual evaluation of plasma levels of c-reactive protein (crp), tumor necrosis factor-alpha (tnf-alpha), interleukin-6 (il-6) and antibodies against chlamydia pneumoniae during a 12-month period following the natural course of aortic valve stenosis (avs). | 2011 | 22655494 |
| comparative seroepidemiologic analysis of chlamydophila pneumoniae infection using microimmunofluorescence, enzyme immunoassay and neutralization test: implications for serodiagnosis. | a seroepidemiologic study using the microimmunofluorescence (mif) technique was conducted to determine the prevalence of chlamydophila pneumoniae igg antibodies among 205 healthy singapore university undergraduates using the mrl diagnostics mif test kit. the overall seroprevalence was 35.1% with significantly higher seropositivity rates among males than females (48.2 vs. 18.7%, p < 0.001). a comparative study using the labsystems mif test kit was conducted on sera from 192 students. using the mr ... | 2011 | 22654169 |
| early atherosclerotic plaques show evidence of infection by chlamydia pneumoniae. | chlamydia pneumoniae (cpn) could play an important role in the development of atherosclerosis. cpn interferes with hif-1alpha regulation in infected host cells during intracellular replication in hypoxia. we obtained carotid artery specimens with low (n=38), high (n=25) levels of stenosis and 10 middle cerebral arteries. fifty eight percent of the carotids with low levels of stenosis showed evidence of the viable organism. ninety one percent of the positive results were derived from pre-atheroma ... | 2012 | 22652649 |