Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| lncrnas as an intermediate in hpv16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma. | the emerging evidence showed that long noncoding rnas (lncrnas) are involved in cell growth and apoptosis as well as cancer progression and metastasis of malignant tumor, however, limited data are available on the role of lncrnas in human papillomavirus (hpv)-associated head and neck squamous cell carcinomas (hnscc). here, we demonstrated that 23.98% of 196 hnscc cases in southwest china could be classified as hpv16 infection. the number of mdscs in hpv-positive hnscc was significantly higher th ... | 2017 | 28159935 |
| sexual and reproductive health in spanish university students. a comparison between medical and law students. | to describe behaviors and knowledge related to sexual and reproductive health of spanish university students and their association with the subject area studied (biomedical or not). | 2017 | 28159136 |
| ambiguous bodies, uncertain diseases: knowledge of cervical cancer in papua new guinea. | within their local realities, people experience and interpret disease in diverse ways that do not necessarily correlate or converge with western biomedical interventions. in the high cervical cancer burden setting of papua new guinea, understanding how people experience and interpret cervical cancer is necessary for effective intervention. drawing on work by street on the production of unstable biomedical knowledge, we explored how ambiguity and uncertainty, coupled with cultural taboos and ling ... | 2017 | 28158947 |
| development of a simple and quick immunochromatography method for detection of anti-hpv-16/-18 antibodies. | immunochromatography (ic) is widely used to detect target molecules in biological fluids. since this method can be performed without a special technique or device, ic is a convenient way to assess the existence of antibodies or pathogens such as viruses and bacteria, simply and quickly. in this study, we established an ic method to detect serum antibodies against oncogenic human papillomavirus (hpv)-16 and hpv-18 l1 proteins using recombinant l1 proteins produced by silkworms as antigens. infect ... | 2017 | 28158224 |
| beliefs, perceptions and health-seeking behaviours in relation to cervical cancer: a qualitative study among women in uganda following completion of an hpv vaccination campaign. | background cervical cancer remains a leading cause of morbidity and mortality in uganda. despite earlier information campaigns to introduce human papilloma virus (hpv) vaccination, which also targeted cervical cancer, misinterpretation and misunderstanding of the subject remain high. women in uganda present with cervical cancer at an advanced stage due to poor health-seeking behaviours, with an associated high mortality rate. this project explored beliefs, attitudes, perceptions, and health-seek ... | 2016 | 28157050 |
| hpv vaccines for circumpolar health: summary of plenary session, "opportunities for prevention: global hpv vaccine" and "human papillomavirus prevention: the nordic experience". | in this publication, we provide an overview of the presentations, "opportunities for prevention: global hpv vaccine" and "human papillomavirus prevention: the nordic experience" as a part of the 15th international congress on circumpolar health, held at anchorage, alaska, on august 8, 2012. we provide an overview of hpv, hpv vaccines and policy as well as the nordic experience with hpv vaccine introduction. | 2013 | 28156289 |
| human papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in luanda, angola. | cervical cancer is the leading cause of cancer deaths among females in angola and human papillomavirus (hpv) is the main risk factor for the development of pre-cancerous squamous intraepithelial lesions. the diversity and frequency of hpv types in angola has yet to be reported. | 2016 | 28154623 |
| human papillomavirus-associated neoplasms of the head and neck. | human papillomavirus (hpv) is an essential causal factor in a subset of head and neck neoplasms, most notably oropharyngeal squamous cell carcinoma, for which hpv infection has important diagnostic, prognostic, and therapeutic implications. this article summarizes the current understanding of hpv-associated neoplasms of the head and neck, including the recently described carcinoma with adenoid cystic-like features. salient clinical, gross, and microscopic features are discussed, and the utility ... | 2017 | 28153135 |
| pragmatic trial of an intervention to increase human papillomavirus vaccination in safety-net clinics. | human papillomavirus (hpv) infection has been causally linked to six cancers, and many disproportionately affect minorties. this study reports on the development and effectiveness of an intervention aimed at increasing hpv vaccine uptake among african american and hispanic pediatric patients in safety-net clinics. | 2017 | 28153042 |
| role of tlr9 in oncogenic virus-produced cancer. | nucleic acid recognition by toll-like receptor 9 (tlr9) initiates signaling pathways that regulate the production of proinflammatory cytokines or type i interferons, as well as many other molecules required to initialize the immune response. the use of synthetic oligodeoxynucleotides (odns) has been crucial to emulate the recognition of dna sequences by tlr9. furthermore, odn administration to mice has shown to confer protection against a wide range of viral, bacterial, and parasitic pathogens. ... | 2017 | 28151089 |
| oral human papillomavirus infection incidence and clearance: a systematic review of the literature. | subclinical oral hpv infection that persists for decades is likely to precede a hpv-driven hnscc, however little is known about the natural history of oral hpv. we systematically reviewed and abstracted data from nine manuscripts that examined hiv-negative and cancer-free subjects for oral hpv dna to determine the pooled baseline prevalence and incidence of newly acquired oral hpv infections, and specifically for hpv-16. we also documented the clearance rate and the median time to clearance, whe ... | 2017 | 28150575 |
| bizarre cell dysplasia of the cervix. | the aim of this study was the characterization of a new subtype of high-grade cervical squamous intraepithelial lesion (hsil) with enlarged cells containing bizarre nuclei: so-called bizarre cell dysplasia (bcd). | 2017 | 28150409 |
| skin cancer: epidemiology, disease burden, pathophysiology, diagnosis, and therapeutic approaches. | skin cancer, including both melanoma and non-melanoma, is the most common type of malignancy in the caucasian population. firstly, we review the evidence for the observed increase in the incidence of skin cancer over recent decades, and investigate whether this is a true increase or an artefact of greater screening and over-diagnosis. prevention strategies are also discussed. secondly, we discuss the complexities and challenges encountered when diagnosing and developing treatment strategies for ... | 2017 | 28150105 |
| wart on fire: a rare entity of verruciform xanthoma arising on a lower leg in a setting of chronic lymphedema. | 2017 | 28149940 | |
| health economic evaluation of human papillomavirus vaccines in women from venezuela by a lifetime markov cohort model. | cervical cancer (cc) and genital warts (gw) are a significant public health issue in venezuela. our objective was to assess the cost-effectiveness of the two available vaccines, bivalent and quadrivalent, against human papillomavirus (hpv) in venezuelan girls in order to inform decision-makers. | 2017 | 28148228 |
| human papillomavirus (hpv) and cervical cancer. | cervical cancer is one of the most common cancer in women in poland and in the world. the main risk factor for this cancer is persistent infection with high - risk human papillomavirus (hpv-hr) types. the most important role in carcinogenesis is attributed to viral oncoproteins e6 and e7, that affect some cell cycle proteins. diagnosis of hpv infection, in which the molecular test play an important role, allow for detection on precancerous lesions of the cervix, and effective treatment of these ... | 2017 | 28146625 |
| colorectal cancer prevalence linked to human papillomavirus: a systematic review with meta-analysis. | colorectal cancer is one of the most prevalent types of tumors worldwide. deaths caused by these malignant tumors remain high and have stayed practically at the same level for the last few decades. among the established risk factors for the development of cancer are infections due to pathogens or viruses. among the viruses, the human papillomavirus (hpv) is the most prevalent, with over 180 strains, 40 of which are directly related to anogenital infections. | 2017 | 28146168 |
| does p53 codon 72 polymorphism have a prognostic value in carcinoma of the vulva and vagina? | human papilloma virus (hpv) is considered to be responsible for a large part of vaginal and vulvar carcinomas, and the p53 codon 72 polymorphism has been implicated in susceptibility to cancer induced by this virus, but with contradicting results. in this study, we have investigated the prognostic value of the codon 72 polymorphism by real-time pcr (qpcr) in two cohorts of vaginal (n = 66) and vulvar (n = 123) carcinomas. in vaginal carcinoma, arginine homozygous patients were significantly asso ... | 2017 | 28144815 |
| multimodality functional imaging using dw-mri and (18)f-fdg-pet/ct during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: meixoeiro hospital of vigo experience. | to noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging (dw-mri) and glucose metabolism measured by (18)f-labeled fluorodeoxyglucose positron emission tomography/computed tomography ((18)f-fdg-pet/ct) during radiation therapy (rt) for human papillomavirus negative (hpv-) head and neck squamous cell carcinoma (hnscc). | 2017 | 28144403 |
| burden of cervical cancer and role of screening in india. | cervical cancer is a major cause of cancer mortality in women and more than a quarter of its global burden is contributed by developing countries. in india, in spite of alarmingly high figures, there is no nationwide government-sponsored screening program. this study was conducted to assess the burden of cervical cancer in india and review the performance characteristics of available cervical cancer screening tools, so as to provide evidence-based recommendations for application of most practica ... | 2017 | 28144096 |
| role of host-microrna hsa-mir-139-3p in hpv-16 induced carcinomas. | human papillomavirus 16 (hpv-16) is important risk factor in head and neck cancer (hnc). studies suggest that micrornas play an important role in cancer, however, their role in hpv mediated oncogenesis remains largely unknown. we investigated the role of micrornas with hpv-16 as putative target in hpv-16 mediated cancers. | 2017 | 28143871 |
| methylation at 3'lcr of hpv16 can be affected by patient age and disruption of e1 or e2 genes. | cpg methylation at early promoter of hpv16 dna, in the 3' end of the long control region (3'lcr), has been associated to the presence of episomal forms of viral genome and, consequently, intact e1 and e2 orfs. the dna methylation would block the access of e2 viral protein to the e2 binding sites at early-promoter. however, is still unclear if methylation at 3'lcr of hpv16 dna can also vary depending of other tumor characteristics in addition to viral dna physical state. in this study, we evaluat ... | 2017 | 28143725 |
| epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets. | epigenetic modifications are heritable changes in gene expression that do not directly alter dna sequence. these modifications include dna methylation, histone post-translational modifications, small and non-coding rnas. alterations in epigenetic profiles cause deregulation of fundamental gene expression pathways associated with carcinogenesis. the role of epigenetics in oropharyngeal squamous cell carcinoma (opscc) has recently been recognized, with implications for novel biomarkers, molecular ... | 2017 | 28143553 |
| human papillomavirus infections among women with cervical lesions and cervical cancer in eastern china: genotype-specific prevalence and attribution. | cervical cancer and its precursor, high-grade cervical intraepithelial neoplasia (cin2/3), are associated with persistent high-risk human papillomavirus (hpv) infection. hpv genotype prevalence varies with severity of cervical lesions, patient age and geographical location. the aim of this study was to investigate hpv genotypes prevalence and attribution according to the severity of cervical lesions among chinese women. | 2017 | 28143439 |
| role of the common fragile sites in cancers with a human papillomavirus etiology. | high-risk human papillomaviruses (hpvs) are known to be associated with different anogenital cancers including cervical, anal, penile, and vaginal cancers. they are also found to be responsible for the dramatic increases in oropharyngeal squamous cell carcinoma (opscc) observed in the united states and europe. the model for how high-risk hpvs induce cancer formation comes from studies of cervical cancer which usually involves integration of the hpv into the human genome and subsequent changes du ... | 2016 | 28142148 |
| e6 and e7 gene polymorphisms in human papillomavirus types-58 and 33 identified in southwest china. | cancer of the cervix is associated with infection by certain types of human papillomavirus (hpv). the gene variants differ in immune responses and oncogenic potential. the e6 and e7 proteins encoded by high-risk hpv play a key role in cellular transformation. hpv-33 and hpv-58 types are highly prevalent among chinese women. to study the gene intratypic variations, polymorphisms and positive selections of hpv-33 and hpv-58 e6/e7 in southwest china, hpv-33 (e6, e7: n = 216) and hpv-58 (e6, e7: n = ... | 2017 | 28141822 |
| prevalence of anal hpv and anal dysplasia in hiv-infected women from johannesburg, south africa. | anal cancer is a relatively common cancer among hiv-infected populations. there are limited data on the prevalence of anal high-risk human papillomavirus (hr-hpv) infection and anal dysplasia in hiv-infected women from resource-constrained settings. | 2017 | 28141783 |
| is p16 an adequate surrogate for human papillomavirus status determination? | in head and neck cancer management, immunoexpression of protein p16 is widely used as a surrogate marker for human papillomavirus (hpv) positivity due to challenges of direct hpv testing. previously p16 has been reported to have good sensitivity but only moderate specificity in hpv-status determination. the aim of this review is to evaluate the existing information on sensitivity and specificity of p16 immunohistochemistry (ihc) in hpv-status determination among the recent studies. | 2017 | 28141601 |
| a longitudinal online interprofessional education experience involving family nurse practitioner students and pharmacy students. | interprofessional education (ipe) continues to gain traction worldwide. challenges integrating ipe into health profession programmes include finding convenient times, meeting spaces, and level-appropriate assignments for each profession. this article describes the implementation of a 21-month prospective cohort study pilot programme for the master of science in nursing family nurse practitioner (fnp) and doctor of pharmacy (pharmd) students at a private university in the united states. this ipe ... | 2017 | 28140703 |
| pediatric laryngeal carcinoma in a heterozygous carrier of fanconi anemia. | a case of invasive, keratinizing squamous cell carcinoma of the larynx in an 8-year-old female treated with laryngectomy is presented. perinatal exposure to human papilloma virus and constitutional heterozygosity for a fancc mutation were identified, though fancc heterozygosity is not known to be cancer predisposing. an additional tumor-associated mutation in notch1 was also identified potentially contributing to oncogenesis. this case illustrates an exceedingly rare type of cancer in the pediat ... | 2017 | 28139070 |
| involvement of retinoblastoma-associated protein 48 during photodynamic therapy of cervical cancer cells. | 5-aminolevulinic acid-mediated photodynamic therapy (ala‑pdt) is an effective treatment option for cervical intraepithelial neoplasia, the precancerous lesion of cervical cancer, and early cervical cancer, particularly for young or nulliparous women who want to remain fertile. a previous report described the involvement of histone deacetylases (hdac) during ala‑pdt mediated apoptosis in the cerebral cortex of a mouse model. retinoblastoma‑associated protein 48 (rbap48), a highly abundant compone ... | 2017 | 28138695 |
| human papillomavirus genotypes associated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, longnan, china. | the mortality of cervical cancer in longnan is as high as 39/10 million, ranking first in china. | 2017 | 28138337 |
| assessment of the knowledge, attitude and practices about human papilloma virus vaccine among the nurses working in a tertiary hospital in china: a cross-sectional descriptive study. | to assess the knowledge about human papilloma virus infection and vaccine, to ascertain the attitude and practices about the vaccine, and to ascertain the determinants preventing people from getting themselves vaccinated. | 2017 | 28138173 |
| combining chk1/2 inhibition with cetuximab and radiation enhances in vitro and in vivo cytotoxicity in head and neck squamous cell carcinoma. | egfr inhibition and radiotherapy are potent inducers of dna damage. checkpoint kinases 1 and 2 (chk1/2) are critical regulators of the dna-damage response, controlling cell-cycle checkpoints that may permit recovery from therapy-associated genomic stress. we hypothesized that chk1/2 inhibition (chki) with prexasertib may enhance cytotoxicity from egfr inhibition plus radiotherapy in head and neck squamous cell carcinoma (hnscc). in this study, we found that the addition of chki to the egfr inhib ... | 2017 | 28138028 |
| association of epithelial atypia with recurrence after surgical excision in conjunctival papilloma. | to investigate the association between recurrence of conjunctival papillomas and presence of atypical epithelial changes in patients undergoing surgical excision for conjunctival papilloma. | 2017 | 28134665 |
| chemotherapy for localized head and neck squamous cell cancers. | concomitant chemotherapy with cisplatin (100 mg/m every 3 weeks) improves outcome for high-risk patients in the postoperative setting and for inoperable disease. toxicity is increased. other schemes of potentiation are sometimes used to reduce toxicity, but efficiency is diminished. cetuximab also improves outcome, but there has been no direct comparison with cisplatin. immunotherapy is currently being evaluated in association with radiation therapy. trials are ongoing to evaluate the impact of ... | 2017 | 28134662 |
| fine-needle aspiration biopsy of hpv-related squamous cell carcinoma of the head and neck: current ancillary testing methods for determining hpv status. | human papillomavirus (hpv)-related head and neck squamous cell carcinoma (hnscc) is a unique form of carcinoma that largely arises from the tonsillar tissue in the oropharynx. these tumors often present with cervical lymphadenopathy resulting in a fine needle aspiration (fna) biopsy. use of the cytology specimen to determine the hpv-status has significant prognostic and treatment implications as hpv-related tumors have a more favorable prognosis and response to nonsurgical therapies. while sever ... | 2017 | 28134480 |
| human papillomavirus positivity in the anal canal in hiv-infected and hiv-uninfected men who have anal sex with men in guangzhou, china: implication for anal exams and early vaccination. | background. the epidemiology of hpv in men who have sex with men (msm) in guangzhou, china, had not been reported previously. methods. hiv-infected and hiv-uninfected msm were recruited from a guangzhou-based msm clinic in 2013. sociodemographic characteristics and sexual behaviors were collected. an anal cytological sample was taken for hpv testing. results. we recruited 79 hiv-infected and 85 hiv-uninfected msm. the median age was 26 years in both groups. the positivities of anal hpv of any ty ... | 2017 | 28133605 |
| determinants of hpv vaccine awareness and healthcare providers' discussion of hpv vaccine among females. | two human papillomavirus (hpv) vaccines are available and can prevent 98% of hpv 16 and 18 infections. this study aimed to explore determinants of 1) hpv vaccine awareness among a cohort of low-income women participating in a cancer prevention program in central texas and compare them to united states residents; 2) determinants of healthcare providers' discussion of hpv vaccine among female residents of the united states. bivariate and multivariable analysis of hpv vaccine awareness using survey ... | 2017 | 28133601 |
| immunotolerant indoleamine-2,3-dioxygenase increases in condyloma acuminata. | the tryptophan-depleting enzyme indoleamine-2,3-dioxygenase (ido) is critical for the regulation of immune tolerance and plays an important role in immune-associated skin diseases. | 2017 | 28132413 |
| particle-mediated intravenous delivery of antigen mrna results in strong antigen-specific t-cell responses despite the induction of type i interferon. | cancer vaccines based on mrna are extensively studied. the fragile nature of mrna has instigated research into carriers that can protect it from ribonucleases and as such enable its systemic use. however, carrier-mediated delivery of mrna has been linked to production of type i interferon (ifn) that was reported to compromise the effectiveness of mrna vaccines. in this study, we evaluated a cationic lipid for encapsulation of mrna. the nanometer-sized, negatively charged lipid mrna particles (lm ... | 2016 | 28131274 |
| on the association between human papillomavirus vaccine and sleep disorders: evaluation based on vaccine adverse events reporting systems. | 2017 | 28131183 | |
| proteomic comparison of chelidonium majus l. latex in different phases of plant development. | chelidonium majus l. (papaveraceae) latex is used in traditinonal folk medicine to treat papillae, warts, condylomas, which are visible effects of human papilloma virus (hpv) infections. the aim of this work was to provide new insights into the biology and medicinal use of c. majus milky sap in the flowering and fruit ripening period of the plant by comparing the protein content between samples collected on respective developmental stages using lc-ms-based label-free proteome approach. for quant ... | 2017 | 28131060 |
| high-risk human papillomavirus in anal squamous cell carcinoma: a "conservative" leading role. | 2017 | 28130278 | |
| promoting hpv vaccination online. | we investigated the effects of message framing and online media channel on young adults' perceived severity of human papillomavirus (hpv), perceived barriers and benefits of getting hpv vaccination, and behavioral intention to get vaccinated. an experiment was conducted with 142 college students. we found an interaction effect: the loss-framed message posted on facebook was more effective in increasing the number of people who expressed their willingness to get hpv vaccination than the gain-fram ... | 2017 | 28129691 |
| age-related changes in pre- and post-conization hpv genotype distribution among women with high-grade cervical intraepithelial neoplasia. | to assess the effect of age on pre- and post-conization hpv genotype distribution. | 2017 | 28129439 |
| costing of national sti program implementation for the global sti control strategy for the health sector, 2016-2021. | in 2016 the world health assembly adopted the global strategy on sexually transmitted infections (sti) 2016-2021 aiming to reduce curable stis by 90% by 2030. we costed scaling-up priority interventions to coverage targets. | 2017 | 28129372 |
| head and neck cancers-major changes in the american joint committee on cancer eighth edition cancer staging manual. | answer questions and earn cme/cne the recently released eighth edition of the american joint committee on cancer (ajcc) staging manual, head and neck section, introduces significant modifications from the prior seventh edition. this article details several of the most significant modifications, and the rationale for the revisions, to alert the reader to evolution of the field. the most significant update creates a separate staging algorithm for high-risk human papillomavirus-associated cancer of ... | 2017 | 28128848 |
| no evidence for cross-protection of the hpv-16/18 vaccine against hpv-6/11 positivity in female sti clinic visitors. | data from a vaccine trial and from post-vaccine surveillance in the united kingdom have suggested that the bivalent hpv-16/18 vaccine offers cross-protection against hpv-6/11 and protection against anogenital warts (agw). we studied the effect of the bivalent vaccine on genital hpv-6/11 positivity and agw in the netherlands. | 2017 | 28126492 |
| impact of louisiana's hpv vaccine awareness policy on hpv vaccination among 13- to 17-year-old females. | the advisory committee on immunization practices recommends routine human papillomavirus (hpv) immunization for 11- to 12-year-old adolescents. in 2008, louisiana required the school boards to distribute hpv vaccine information to parents or guardian of students in grades 6 to 12. this article investigates the impact of this policy on hpv vaccination among 13- to 17-year-old female adolescents using national immunization survey-teen (nis-teen) data. drawing on the data from the 2008 to 2012 nis- ... | 2017 | 28125911 |
| immediate referral to colposcopy versus cytological surveillance for minor cervical cytological abnormalities in the absence of hpv test. | a significant number of women are diagnosed with minor cytological abnormalities on cervical screening. many authorities recommend surveillance as spontaneous regression might occur. however, attendance for cytological follow-up decreases with time and might put some women at risk of developing invasive disease. | 2017 | 28125861 |
| invasive cancer incidence and survival - united states, 2013. | although cancer represents many heterogeneous diseases, some cancer types share common risk factors. for example, conclusive evidence links cancer at multiple sites with tobacco use, alcohol use, human papillomavirus (hpv) infection, excess body weight, and physical inactivity (1,2). to monitor changes in cancer incidence and assess progress toward achieving healthy people 2020 objectives,* cdc analyzed data from the u.s. cancer statistics (uscs) data set for 2013, the most recent year for which ... | 2017 | 28125576 |
| patterns of persistent hpv infection after treatment for cervical intraepithelial neoplasia (cin): a systematic review. | a systematic review of the literature was conducted to determine the estimates of and definitions for human papillomavirus (hpv) persistence in women following treatment of cervical intra-epithelial neoplasia (cin). a total of 45 studies presented data on post-treatment hpv persistence among 6,106 women. most studies assessed hpv persistence after loop excision (42%), followed by conization (7%), cryotherapy (11%), laser treatment (4%), interferon-alpha, therapeutic vaccination, and photodynamic ... | 2017 | 28124442 |
| cervical intraepithelial neoplasia in pregnancy: interference of pregnancy status with p16 and ki-67 protein expression. | to date, there are evidence-based guidelines available for cervical dysplasia diagnosed in pregnancy. certain functional biomarkers have proven useful in the prediction of regressing and non-regressing cervical intraepithelial neoplasia (cin) lesions in non-pregnant women. in the present study, ki-67 and p16 immunostaining were evaluated in different grades of cin lesions diagnosed in pregnant or non-pregnant women with the aim to identify any differences in order to better understand the behavi ... | 2017 | 28123559 |
| human papillomavirus and mandatory immunization laws: what can we learn from early mandates? | 2016 | 28123214 | |
| via/vili is more suitable for cervical cancer prevention in chinese poverty-stricken region: a health economic evaluation. | screening is the main preventive method for cervical cancer in developing countries, but each type of screening has advantages and disadvantages. to investigate the most suitable method for low-income areas in china, we conducted a health economic analysis comparing three methods: visual inspection with acetic acid and lugol's iodine (via/vili), thinprep cytology test (tct), and human papillomavirus (hpv) test. | 2017 | 28122530 |
| distinct patterns of infiltrating cd8+ t cells in hpv+ and cd68 macrophages in hpv- oropharyngeal squamous cell carcinomas are associated with better clinical outcome but pd-l1 expression is not prognostic. | immunotherapies are beginning to revolutionise treatment paradigms in oncology with monoclonal antibodies (mab) targeting t-cell co-inhibitory (e.g. pd-1/pd-l1) and co-stimulatory pathways (e.g. ctla-4/cd28) demonstrating clinical utility. some clinical studies demonstrate that responsiveness to pd-1/pd-l1 mab therapy is greater in patients with expression of pd-l1 in the tumour microenvironment. however, robust responses have also been observed in patients with low or absent expression of pd-l1 ... | 2017 | 28122336 |
| multiple preinvasive and invasive hpv-related lesions of the anogenital tract in a female patient with hiv infection: a case report. | patients with human immunodeficiency virus (hiv) infection have been shown to be at increased risk for high-risk human papillomavirus (hr-hpv) infection of the anogenital tract. furthermore, in the last decades, the introduction of highly active antiretroviral therapy (haart) has increased the longevity of these patients who now live long enough to develop hpv-related cancers; hence, the impact of hpv infection on hiv-positive patients is of increasing concern. | 2017 | 28121939 |
| human papillomavirus antibody response following haart initiation among msm. | to describe effects of haart on high-risk human papillomavirus (hpv) antibody response in hiv-positive msm and the meaning of this response for subsequent hpv-related cancer risk. | 2017 | 28121669 |
| ranpirnase eradicates human papillomavirus in cultured cells and heals anogenital warts in a phase i study. | human papillomaviruses (hpv), the causative agents of anogenital warts, are the most prevalent sexually transmitted infectious agents, and wart treatment poses a persistent challenge. we assessed the safety and efficacy of treating hpv with ranpirnase, an endoribonuclease from the northern leopard frog that has been used extensively in phase iii oncology trials. | 2017 | 28121292 |
| association of hpv infection and clearance with cervicovaginal immunology and the vaginal microbiota. | cervical human papillomavirus (hpv) infection may increase hiv risk. since other genital infections enhance hiv susceptibility by inducing inflammation, we assessed the impact of hpv infection and clearance on genital immunology and the cervico-vaginal microbiome. genital samples were collected from 65 women for hpv testing, immune studies and microbiota assessment; repeat hpv testing was performed after 6 months. all participants were hiv-uninfected and free of bacterial stis. cytobrush-derived ... | 2017 | 28120845 |
| pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. practical messages from the eular guidelines. | over the last few decades, reproductive medicine has observed an improvement in the management and outcome of pregnancy in connective tissue diseases, such as systemic lupus erythematosus (sle) and antiphospholipid syndrome (aps). however, pregnancy and related issues remain a challenge in these patients. in routine clinical practice, health professionals dealing with sle and aps need to consider the numerous aspects of the reproductive life of their patients, such as pregnancy, family planning, ... | 2017 | 28120818 |
| detection of human papillomavirus type 35 in recurrent bowen's disease lesions of the fingers. | 2017 | 28120774 | |
| cervical cancer incidence after screening with hpv, cytology, and visual methods: 18-year follow-up of the guanacaste cohort. | testing negative for human papillomavirus (hpv) predicts long-term reassurance against invasive cervical cancer (icc). to provide realistic estimates of effectiveness for new screening programs, we studied icc risk after a 7-year repeated multimethod screening effort. in 1993-1994, 10,049 women aged 18-97 years were enrolled into a population-based cohort study of cervical hpv in guanacaste, costa rica. women were screened at different intervals according to enrollment results. each visit (mean ... | 2017 | 28120391 |
| a 3-year interval is too short for re-screening hpv negative women: a population-based cohort study. | to compare the results of the first round and of re-screening 3 years after a negative human papillomavirus (hpv) test in women attending two hpv-based screening programs. | 2017 | 28120382 |
| α-defensin hd5 inhibits human papillomavirus 16 infection via capsid stabilization and redirection to the lysosome. | α-defensins are an important class of abundant innate immune effectors that are potently antiviral against a number of nonenveloped viral pathogens; however, a common mechanism to explain their ability to block infection by these unrelated viruses is lacking. we previously found that human defensin 5 (hd5) blocks a critical host-mediated proteolytic processing step required for human papillomavirus (hpv) infection. here, we show that bypassing the requirement for this cleavage failed to abrogate ... | 2017 | 28119475 |
| genome-wide dna methylation profiling reveals methylation markers associated with 3q gain for detection of cervical pre-cancer and cancer. | epigenetic host cell changes involved in cervical cancer development following a persistent high-risk human papillomavirus (hrhpv) infection, provide promising markers for the management of hrhpv-positive women. in particular, markers based on dna methylation of tumour suppressor gene promoters are valuable. these markers ideally identify hrhpv-positive women with pre-cancer (cin2/3) in need of treatment. here, we set out to identify biologically relevant methylation markers by genome-wide methy ... | 2017 | 28119363 |
| ecological validity of cost-effectiveness models of universal hpv vaccination: a protocol for a systematic review. | sexually transmitted infection with high-risk, oncogenic strains of human papillomavirus (hpv) still induces a relevant burden of diseases on both men and women. although vaccines appear to be highly efficacious in preventing the infection of the most common high-risk strains (hpv 6, 11, 16, 18), important questions regarding the appropriate target population for prophylactic vaccination are still debated. models in the extant literature seem to converge on the cost-effectiveness of high coverag ... | 2017 | 28118846 |
| a plant protein signal sequence improved humoral immune response to hpv prophylactic and therapeutic dna vaccines. | signal sequences (ss) play a critical role in the sorting of nascent secretory and membrane proteins. this function has been conserved from bacteria through eukaryotes, although ss appear diverse in length and amino acid composition. sorting of proteins is also critical to instruct antigens for a proper immunological response. thus, a plant ss was used to drive human papillomavirus (hpv) model antigens into the human secretory pathway: the hpv16 e7 oncoprotein, its chimera with the coat protein ... | 2017 | 28118086 |
| [sexuality risk factors among people with suspect of sexually transmitted disease]. | describing determinants factors in sexually transmitted diseases is necessary to evaluate and design effective measures for prevention and treatment. the aim of this research was to determine the sexual risk factors of people who are treated at sexually transmitted diseases centre and to analyze differences based on gender. | 2017 | 28117765 |
| endocervical carcinogenesis and hpv vaccination: an occasional circumstance or a gap in the chain? | as a result of the human papillomavirus (hpv) vaccination program, the prevalence of precancerous dysplasia and invasive cervical cancer has substantially decreased. in this brief report, we present a case of a young patient who was diagnosed with in situ adenocarcinoma of the cervix. this 30-year-old female had completed the hpv vaccination after she became sexually active and has been undergoing annual gynecological assessments, including clinical examination and pap test, all of which had bee ... | 2017 | 28116194 |
| human papillomavirus infection in anal intraepithelial lesions from hiv infected cuban men. | an association between hpv infection and progression to anal squamous intraepithelial lesions (asil) has been established, specifically in high-risk populations such as hiv-infected men. in this population, anal cancer is one of the most common non-aids-defining malignancies. | 2017 | 28115985 |
| induction of dormancy in hypoxic human papillomavirus-positive cancer cells. | oncogenic human papillomaviruses (hpvs) are closely linked to major human malignancies, including cervical and head and neck cancers. it is widely assumed that hpv-positive cancer cells are under selection pressure to continuously express the viral e6/e7 oncogenes, that their intracellular p53 levels are reconstituted on e6/e7 repression, and that e6/e7 inhibition phenotypically results in cellular senescence. here we show that hypoxic conditions, as are often found in subregions of cervical and ... | 2017 | 28115701 |
| prevalence of genital human papillomavirus infection and human papillomavirus vaccination rates among us adult men: national health and nutrition examination survey (nhanes) 2013-2014. | human papillomavirus (hpv) is a common sexually transmitted infection that is a major cause of noncervical anogenital and oropharyngeal cancers. prophylactic hpv vaccine is available for primary prevention. however, the population prevalence data for male genital hpv infection is not well known, while the hpv vaccination coverage is low in the united states. | 2017 | 28114440 |
| prevalence of and associated risk factors for high risk human papillomavirus among sexually active women, swaziland. | high risk human papillomavirus (hr-hpv) infection and the dual burden of hiv remains a huge challenge in some low-income countries (lics) such as swaziland with limited or no data. we estimated the prevalence and investigated determinants of hr-hpv, including hiv infection among sexually active women in swaziland. | 2017 | 28114325 |
| can human papillomavirus dna self-sampling be an acceptable and reliable option for cervical cancer screening in female sex workers? | the causal relation between human papillomavirus (hpv) and cervical cancer has enabled hpv self-sampling to be envisaged as a possible screening method. | 2017 | 28114260 |
| integrated genomic and molecular characterization of cervical cancer. | cervical cancer remains one of the leading causes of cancer-related deaths worldwide. here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. we observed notable apobec mutagenesis patterns and identified shkbp1, erbb3, casp8, hla-a and tgfbr2 as novel significantly mutated genes in cervical cancer. we also discovered amplifications in immune targets cd274 (also known as pd-l1) and pdcd1 ... | 2017 | 28112728 |
| [molecular detection of sexually transmitted agents in a symptomatic group of men and its relationship with sexual behavior]. | sexually transmitted infections (stis) affect sexual and reproductive health of millions of men. pathogens such as human papillomavirus (hpv), herpes simplex virus type 1 and 2 (hsv-1 y hsv-2), chlamydia trachomatis,mycoplasmagenitalium,mycoplasma hominis and ureaplasma urealyticum are associated with stis. | 2016 | 28112332 |
| cancer control-a global perspective. | disparities in cancer control exist in low- and middle-income countries (lmics). many countries do not have cancer registries to record incidence, mortality and prevalence and are reliant on globocan estimates of their cancer burden. poorer cancer control within and between countries occurs in those living remotely from urban centres, those in a low socioeconomic group and some ethnic groups who have lifestyle and belief systems which impact on cancer control. high-income countries generally hav ... | 2017 | 28111859 |
| therapeutic use of the hpv vaccine in recurrent respiratory papillomatosis: a case report. | recurrent respiratory papillomatosis (rrp) is a condition characterized by recurring squamous papillomas in the aerodigestive tract due to human papilloma virus (hpv) infection. treatment includes surgical debridement of the lesions often with adjuvant therapy. a newer adjuvant agent being tested is the hpv vaccine. the case report includes a child with rrp who underwent 10 surgeries in a year with an average inter-surgical interval (isi) of 46 days. the patient then received the scheduled regim ... | 2017 | 28109479 |
| predictors of extracapsular extension in hpv-associated oropharyngeal cancer treated surgically. | extracapsular extension (ece) in cervical metastatic lymph nodes remains an indication for adding chemotherapy for patients with oropharyngeal squamous cell carcinoma (opscc). the aim of this study is to identify specific imaging characteristics on computed tomography (ct) scan that are predictive of ece in order to better risk stratify patients preoperatively. | 2017 | 28109475 |
| competing causes of death in the head and neck cancer population. | the increasing survivorship of head and neck squamous cell carcinoma (hnscc) comes with a risk of death from other causes, known as competing causes. the demographics of hnscc are also evolving with increasing incidence of human papillomavirus (hpv) associated tumors. this study describes competing causes of death for the hnscc population compared to the general population and identifies associated risk factors. | 2017 | 28109473 |
| risk of high-grade precancerous lesions and invasive cancers in high-risk hpv-positive women with normal cervix or cin 1 at baseline-a population-based cohort study. | infection with high-risk human papillomavirus (hr-hpv) is transient and clears on its own in majority of the women. only a few women who have persistent infection may finally develop cervical intraepithelial neoplasia (cin) or cervical cancer in later years. the risk of progression in the hr-hpv-positive women with normal cervix or low-grade lesion on colposcopy and histopathology at baseline is less studied. we performed a longitudinal study on 650 hr-hpv-positive women with colposcopy and/or h ... | 2017 | 28108997 |
| intralesional immunotherapy compared to cryotherapy in the treatment of warts. | warts are the most common clinical manifestation of the human papilloma-virus infection in the skin and mucous membranes. in spite of the various therapeutic modalities for nongenital skin warts, there is still no single method to be used as an approved treatment. in this study, we compared the efficacy of immunotherapy and cryotherapy on wart lesions. | 2017 | 28108992 |
| geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. | human papillomavirus (hpv) causes oropharyngeal squamous cell carcinoma (opscc), although strongly divergent results have been reported regarding the prevalence of hpv16 in different countries, whether this represents important differences in etiology remains unclear. applying rigorous protocols for sample processing, we centrally evaluated 1,420 head and neck tumors (533 oropharynx, 395 oral cavity and 482 larynx) from studies conducted in the us, europe and brazil for mucosal hpv dna and p16(i ... | 2017 | 28108990 |
| do educational seminars for the human papillomavirus vaccine improve attitudes toward the value of vaccination? | this study aimed to determine the effectiveness and effect of educational seminars given at 2 sites in north central florida on the knowledge of human papillomavirus (hpv), perceived barriers to hpv vaccination, and willingness to vaccinate against hpv in eligible patients. | 2017 | 28108212 |
| cutaneous hpv8 and mmupv1 e6 proteins target the notch and tgf-β tumor suppressors to inhibit differentiation and sustain keratinocyte proliferation. | cutaneous beta-papillomaviruses are associated with non-melanoma skin cancers that arise in patients who suffer from a rare genetic disorder, epidermodysplasia verruciformis (ev) or after immunosuppression following organ transplantation. recent studies have shown that the e6 proteins of the cancer associated beta human papillomavirus (hpv) 5 and hpv8 inhibit notch and tgf-β signaling. however, it is unclear whether disruption of these pathways may contribute to cutaneous hpv pathogenesis and ca ... | 2017 | 28107544 |
| human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer. | human papillomavirus (hpv), in addition to smoking and alcohol, is a cause of oropharyngeal squamous cell carcinoma (opscc), particularly of the tonsils and base of the tongue (tscc and botscc, respectively). moreover, hpv-positive tscc and botscc are associated with a better outcome compared with their hpv-negative counterparts (80 vs. 40% 3-year disease-free survival rate, respectively) and their incidence has increased in several countries. recently, accumulating evidence of hpv in a consider ... | 2016 | 28105346 |
| prevalence and determinants of oral human papillomavirus infection in 500 young adults from italy. | although the prevalence of human papillomavirus (hpv)-related oropharyngeal squamous cell carcinoma (opscc) is increasing in developed countries and becoming a relevant health issue, the natural history of oral hpv infection is still unclear. estimating the infection's prevalence in specific populations and identifying risk factors can widen our understanding of its natural history and help to delineate appropriate prevention strategies. this study sought to (i) determine oral hpv prevalence and ... | 2017 | 28103272 |
| the impact of human papillomavirus type on colposcopy performance in women offered hpv immunisation in a catch-up vaccine programme: a two-centre observational study. | to determine whether human papillomavirus (hpv) immunisation has affected the prevalence of hpv genotypes and colposcopic features of cervical intraepithelial neoplasia (cin) in young women referred for colposcopy. | 2017 | 28102931 |
| reduction in colposcopy workload and associated clinical activity following human papillomavirus (hpv) catch-up vaccination programme in scotland: an ecological study. | to measure patterns of clinical activity at colposcopy before and after vaccinated women entered the scottish cervical screening programme (scsp). | 2017 | 28102928 |
| nonpromoter methylation of the cdkn2a gene with active transcription is associated with improved locoregional control in laryngeal squamous cell carcinoma. | we previously reported a novel association between cdkn2a nonpromoter methylation and transcription (arf/ink4a) in human papillomavirus associated oropharyngeal tumors. in this study we assessed whether nonpromoter cdkn2a methylation in laryngeal squamous cell carcinomas (lxscc) conferred a similar association with transcription that predicted patient outcome. we compared dna methylation and arf/ink4a rna expression levels for the cdkn2a locus using the illumina humanmethylation27 beadchip and r ... | 2017 | 28102032 |
| identification of changes in the human papilloma virus 16 (hpv16) genome during early dissemination of cervical cancer cells may complement histological diagnosis of lymph node metastasis. | cancer of the uterine cervix (cacx) is one of the most common carcinoma affecting women worldwide. during treatment, histologically lymph node (ln) metastasis and presence of hpv dna in blood plasma act as a major prognostic factor. despite the lack of apparent ln involvement, some early-invasive cacx patients have shown recurrences and poor survival. this is suggestive of undetected early dissemination of cancer cells characterized by presence of hpv dna in histologically non-metastatic lns whi ... | 2017 | 28101801 |
| urethral carcinoma in situ: recognition and management. | urethral carcinoma in situ (cis) is an uncommon malignancy that is poorly described in the published literature and is often under-recognized in the clinical setting. this short case series reports some challenges associated with the recognition and management of this disease. | 2017 | 28101735 |
| the biological significance of methylome differences in human papilloma virus associated head and neck cancer. | in recent years, studies have suggested that promoter methylation in human papilloma virus (hpv) positive head and neck squamous cell carcinoma (hnscc) has a mechanistic role and has the potential to improve patient survival. the present study aimed to replicate key molecular findings from previous analyses of the methylomes of hpv positive and hpv negative hnscc in an independent cohort, to assess the reliability of differentially methylated markers in hpv-associated tumors. hpv was measured us ... | 2016 | 28101231 |
| comparison of human papillomavirus detection in urine and cervical samples using high-risk hpv dna testing in northern thailand. | objective. to evaluate the performance of high-risk human papillomavirus (hpv) dna testing in urine samples compared to that of cervical sample testing in northern thailand. methods. paired urine and cervical samples were collected during the follow-up of women with a previous positive hpv test. hpv testing was performed using the cobas 4800 hpv test. linear array assay was used for genotyping in selected cases. results. paired urine and cervical samples were obtained from 168 women. of 123 pair ... | 2016 | 28101107 |
| efficacy of a film-forming medical device containing piroxicam and sun filters in the treatment of multiple actinic keratosis lesions in a subject with a history of kaposi sarcoma. | actinic keratosis (ak) is considered a premalignant form of skin cancer due to chronic sun exposure. in addition, human papilloma virus (hpv) has been advocated a role in the pathogenesis of this clinical condition. hpv proteins (mainly e6 and e7) seem to act synergistically with ultraviolet (uv) radiation in reducing the defensive mechanisms of keratinocyte apoptosis after uv damage. data regarding the involvement of other viruses, i.e. human herpes viruses (hhv), in the pathogenesis of ak are ... | 2017 | 28101017 |
| the acceptability of self-sampled screening for hpv dna: a systematic review and meta-analysis. | to examine whether or not self-sampled cervical screening for human papillomavirus (hpv) dna is acceptable and if women prefer self-sampling to clinician-based sampling. | 2017 | 28100761 |
| the ptpn14 tumor suppressor is a degradation target of human papillomavirus e7. | activation of signaling pathways ensuring cell growth is essential for the proliferative competence of human papillomavirus (hpv)-infected cells. tyrosine kinases and phosphatases are key regulators of cellular growth control pathways. a recently identified potential cellular target of hpv e7 is the cytoplasmic protein tyrosine phosphatase ptpn14, which is a potential tumor suppressor and is linked to the control of the hippo and wnt/beta-catenin signaling pathways. in this study, we show that t ... | 2017 | 28100625 |
| determinants of viral oncogene e6-e7 mrna overexpression in a population-based large sample of women infected by high-risk human papillomavirus types. | cervical cancer screening by human papillomavirus (hpv) dna testing with cytology triage is more effective than cytology testing. compared to cytology, the hpv dna test's higher sensitivity, which allows better protection with longer intervals, makes it necessary to triage the women with a positive result to compensate its lower specificity. we are conducting a large randomized clinical trial (new technologies for cervical cancer 2 [ntcc2]) within organized population-based screening programs in ... | 2017 | 28100595 |