Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| hepatitis b virus infection in undocumented immigrants and refugees in southern italy: demographic, virological, and clinical features. | the data on hepatitis b virus (hbv) infection in immigrants population are scanty. the porpoise of this study was to define the demographic, virological, and clinical characteristics of subjects infected with hbv chronic infection in a cohort of immigrants living in naples, italy. | 2017 | 28179020 |
| hepatitis b virus surface proteins accelerate cholestatic injury and tumor progression in abcb4-knockout mice. | understanding of the pathophysiology of cholestasis associated carcinogenesis could challenge the development of new personalized therapeutic approaches and thus improve prognosis. simultaneous damage might aggravate hepatic injury, induce chronic liver disease and even promote carcinogenesis. we aimed to study the effect of hepatitis b virus surface protein (hbsag) on cholestatic liver disease and associated carcinogenesis in a mouse model combining both impairments. hybrids of abcb4-/- and hbs ... | 2017 | 28178654 |
| different courses of hepatitis b reinfection after renal transplant: a case report. | hepatitis b surface antigen-positive allografts may be a source of transmission in patients who undergo renal transplantation. treatment of hepatitis b virus infection with nucleoside/nucleotide analogs in kidney recipients who have hepatitis b virus infection or who have received transplants from hepatitis b surface antigen-positive donors improves long-term patient survival. antiviral agents are administered as a preemptive or prophylactic therapy at the time of kidney transplantation, rather ... | 2017 | 28176616 |
| netrin-1 protects hepatocytes against cell death through sustained translation during the unfolded protein response. | netrin-1, a multifunctional secreted protein, is up-regulated in cancer and inflammation. netrin-1 blocks apoptosis induced by the prototypical dependence receptors deleted in colorectal carcinoma and uncoordinated phenotype-5. although the unfolded protein response (upr) triggers apoptosis on exposure to stress, it first attempts to restore endoplasmic reticulum homeostasis to foster cell survival. importantly, upr is implicated in chronic liver conditions including hepatic oncogenesis. netrin- ... | 2016 | 28174720 |
| a practical approach to immunotherapy of hepatocellular carcinoma using t cells redirected against hepatitis b virus. | hepatocellular carcinoma (hcc) cells often have hepatitis b virus (hbv)-dna integration and can be targeted by hbv-specific t cells. the use of viral vectors to introduce exogenous hbv-specific t-cell receptors (tcr) on t cells to redirect their specificity is complex and expensive to implement in clinical trials. moreover, it raises safety concerns related to insertional mutagenesis and potential toxicity of long-lived hbv-specific t cells in patients with persistent infection. to develop a mor ... | 2013 | 28173945 |
| autologous neohep derived from chronic hepatitis b virus patients' blood monocytes by upregulation of c-met signaling. | in view of the escalating need for autologous cell-based therapy for treatment of liver diseases, a novel candidate has been explored in the present study. the monocytes isolated from hepatitis b surface antigen (hbsag) nucleic acid test (nat)-positive (hnp) blood were differentiated to hepatocyte-like cells (neohep) in vitro by a two-step culture procedure. the excess neutrophils present in hnp blood were removed before setting up the culture. in the first step of culture, apoptotic cells were ... | 2017 | 28170202 |
| health-related quality of life in pediatric patients with chronic hepatitis b living in the united states and canada. | to determine if selected socio-demographic and hbv-specific clinical factors are associated with health-related quality of life (hrqol) among pediatric patients chronically infected with hepatitis b virus (hbv). | 2017 | 28169971 |
| th17/treg imbalance is an indicator of liver cirrhosis process and a risk factor for hcc occurrence in hbv patients. | to determine the impact of t helper 17 cell (th17)/regulatory t cell (treg) ratio imbalance on the process and prognosis of hepatitis b virus (hbv)-related liver cirrhosis. | 2017 | 28169127 |
| community seroprevalence of hepatitis b, c and human immunodeficiency virus in adult population in gojjam zones, northwest ethiopia. | in ethiopia, there is lack of data on the prevalence of hepatitis b virus (hbv), hepatitis c virus (hcv) and human immune deficiency virus (hiv) infections in adult population at community level. this study aimed at determining the hbv, hcv and hiv seroprevalence in adult population at community level in east and west gojjam zones in amhara region, ethiopia. | 2017 | 28166829 |
| targeting mitochondrial dysfunction can restore antiviral activity of exhausted hbv-specific cd8 t cells in chronic hepatitis b. | hepatitis b virus (hbv)-specific cd8 t cells are functionally exhausted in chronic hepatitis b infection, and this condition can be corrected only partially through the modulation of inhibitory pathways, which suggests that a more complex molecular interplay underlies t cell exhaustion. to gain broader insight into this process and identify additional targets for the restoration of t cell function, we compared the transcriptome profiles of hbv-specific cd8 t cells from patients with acute and ch ... | 2017 | 28165481 |
| changes in red blood cell distribution width is associated with liver function parameters and prognosis in patients with chronic hbv liver disease. | hepatitis b virus (hbv) infection represents a major threat to global public health, especially in china. the clear pathogenesis of chronic hbv infection (chb) has not been fully elucidated, but inflammation is widely accepted to play an important role. emerging evidence suggests that red blood cell distribution (rdw) is a novel potential marker of inflammatory responses. the present study aimed to investigate the clinical relevance of elevated rdw in the patients with chronic hbv liver disease ... | 2016 | 28164679 |
| analysis of biochemical features of hepatitis b virus infected patients in southwest china. | hepatitis b is one of the most common infectious diseases in china, and it is necessary to study biochemical indicators of hbv infected patients. | 2016 | 28164598 |
| effect of serum vitamin d levels on cellular immunity and antiviral effects in chronic hepatitis b patients. | to study the effect of 25-hydroxyl vitamin d3 on peripheral blood t lymphocyte immune function and antiviral effects in chronic hepatitis b patients. | 2016 | 28164523 |
| the characteristics of hepatitis b surface antigen (hbsag)-negative hepatitis b virus (hbv) infection in chinese blood donors: a follow-up study of donors tested negative for hbsag and reactive for simultaneous nucleic acid testing of hbv, hepatitis c virus, and human immunodeficiency virus. | the real infection status of hepatitis b virus (hbv) of hepatitis b surface antigen (hbsag)-negative yet nucleic acid test (nat)-positive blood donors is difficult to clarify. detailed follow-up study is needed for analyzing the infectivity of these blood donors. | 2017 | 28164313 |
| nitrative and oxidative dna damage in infection-related carcinogenesis in relation to cancer stem cells. | infection and chronic inflammation have been recognized as important factors for carcinogenesis. under inflammatory conditions, reactive oxygen species (ros) and reactive nitrogen species (rns) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative dna lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodg) and 8-nitroguanine. the dna damage can cause mutations and has been implicated in inflammation-mediated carcinogenesis. it has bee ... | 2017 | 28163802 |
| role of superoxide dismutase in hepatitis b virus-related hepatocellular carcinoma. | reactive oxygen species (ros) play important roles in hepatocarcinogenesis. superoxide dismutase (sod) is involved in the repair of ros. serum alpha-fetoprotein (afp) is the "golden marker" for diagnosing hepatocellular carcinoma (hcc), and one major shortcoming of its use is that it is insensitive for the early detection of hcc. therefore, we evaluated serum sod levels and their association with afp in hepatitis b virus (hbv)-related hcc. | 2016 | 28163740 |
| pharmaceutical approval update. | prasterone (intrarosa) for the treatment of dyspareunia due to menopause; crisaborole (eucrisa) for the topical treatment of atopic dermatitis; and tenofovir alafenamide (vemlidy) for once-daily treatment of chronic hepatitis b virus infection. | 2017 | 28163553 |
| anti-pd-1/pd-l1 therapy for infectious diseases: learning from the cancer paradigm. | immune checkpoint pathways regulate optimal host immune responses against transformed cells, induce immunological memory, and limit tissue pathology. conversely, aberrant immune checkpoint activity signifies a poor prognosis in cancer and infectious diseases. host-directed therapy (hdt) via immune checkpoint blockade has revolutionized cancer treatment with therapeutic implications for chronic infections, thus laying the foundation for this review. | 2017 | 28163164 |
| autoimmune hepatitis and occult hcv infection: a prospective single-centre clinical study. | 2017 | 28161557 | |
| short-course tocilizumab increases risk of hepatitis b virus reactivation in patients with rheumatoid arthritis: a prospective clinical observation. | to investigate the impact of short-course tocilizumab (tcz) on hepatitis b virus (hbv) reactivation in rheumatoid arthritis (ra) patients. | 2017 | 28160426 |
| clinical characteristics and prognosis of non-b, non-c hepatocellular carcinoma: the impact of patient sex on disease-free survival - a retrospective cohort study. | the number of patients with hepatocellular carcinoma (hcc) negative for both hepatitis b virus surface antigen (hbsag) and hepatitis c virus antibody (hcvab) has increased recently. the purpose of the present study was to investigate the clinical characteristics and prognoses of non-b non-c hcc (nbnc-hcc) patients. | 2017 | 28159713 |
| cxcr5(+) cd8(+) t cells indirectly offer b cell help and are inversely correlated with viral load in chronic hepatitis b infection. | treatment options for chronic hepatitis b (chb) infection are extremely limited. cxcr5(+) cd8(+) t cell is a novel cell subtype and could possess strong cytotoxic properties in hiv infection. in this study, we investigated the role of cxcr5(+) cd8(+) t cells in chb patients. compared to healthy individuals, both chb patients and hepatitis b virus (hbv)-infected hepatocellular carcinoma patients presented significant upregulation of cxcr5(+) cd8(+) t cells in peripheral blood, in which cxcr5(+) c ... | 2017 | 28157399 |
| efficient genome replication of hepatitis b virus using adenovirus vector: a compact pregenomic rna-expression unit. | the complicated replication mechanisms of hepatitis b virus (hbv) have impeded hbv studies and anti-hbv therapy development as well. herein we report efficient genome replication of hbv applying adenovirus vectors (advs) showing high transduction efficiency. even in primary hepatocytes derived from humanized mice the transduction efficiencies using advs were 450-fold higher compared than those using plasmids. by using an expression unit consisting of the cmv promoter, 1.03-copy hbv genome and fo ... | 2017 | 28157182 |
| epidemiology of hepatitis b virus in immigrants crossing to europe from north and sub-saharan africa. | 2017 | 28153710 | |
| hepatitis b virus modulates store-operated calcium entry to enhance viral replication in primary hepatocytes. | many viruses modulate calcium (ca2+) signaling to create a cellular environment that is more permissive to viral replication, but for most viruses that regulate ca2+ signaling, the mechanism underlying this regulation is not well understood. the hepatitis b virus (hbv) hbx protein modulates cytosolic ca2+ levels to stimulate hbv replication in some liver cell lines. a chronic hbv infection is associated with life-threatening liver diseases, including hepatocellular carcinoma (hcc), and hbx modul ... | 2017 | 28151934 |
| sonography predicts liver steatosis in patients with chronic hepatitis b. | liver inflammation and fibrosis may impair the ability of sonography to identify steatosis. we determined the accuracy of sonography in grading steatosis in patients with chronic hepatitis b compared to liver biopsy. | 2017 | 28151547 |
| role of tlr9 in oncogenic virus-produced cancer. | nucleic acid recognition by toll-like receptor 9 (tlr9) initiates signaling pathways that regulate the production of proinflammatory cytokines or type i interferons, as well as many other molecules required to initialize the immune response. the use of synthetic oligodeoxynucleotides (odns) has been crucial to emulate the recognition of dna sequences by tlr9. furthermore, odn administration to mice has shown to confer protection against a wide range of viral, bacterial, and parasitic pathogens. ... | 2017 | 28151089 |
| hepatitis b virus-encoded mirna controls viral replication. | micrornas (mirnas) are a class of small single-stranded non-coding functional rnas. hepatitis b virus (hbv) is an enveloped dna virus with virions and subviral forms of particles that lack a core. it was not known whether hbv encodes mirnas. here, we identified an hbv-encoded mirna (called hbv-mir-3) by deep sequencing and northern blot. hbv-mir-3 is located at nts 373-393 of the hbv genome and was generated from 3.5kb, 2,4kb and 2.1kb hbv in classic mirna biogenesis (drosha-dicer dependent) man ... | 2017 | 28148795 |
| poor sensitivity of rapid tests for the detection of antibodies to the hepatitis b virus: implications for field studies. | rapid tests (rts) can be used as an alternative method for the conventional diagnosis of hepatitis b virus (hbv). this study aims to evaluate antibodies to hbsag (anti-hbs) and antibodies to hbeag (anti-hbe) rts under different brazilian settings. the following three groups were included: gi: viral hepatitis outpatient services; gii: low resource areas; and giii: crack users and beauticians. imuno-rápido anti-hbsag™ and imuno-rápido anti-hbeag™ rts were evaluated and showed specificities greater ... | 2017 | 28146158 |
| clinical validity of metroticket calculator in transplant patients undergoing prior chemoembolization for hepatocellular carcinoma. | to test the predictive performance of the metroticket calculator for survival after liver transplantation (lt) of patients with hepatocellular carcinoma (hcc) undergoing prior transarterial chemoembolization (tace). | 2017 | 28144812 |
| proteomics approaches for early detection and targeted therapy of hepatocellular carcinoma. | hepatocellular carcinoma (hcc) is one of the leading causes of cancer related mortality worldwide. hcc incidences have increased worldwide though more prevalent in asia and africa. hepatitis b virus and hepatitis c virus infections are mostly responsible of increased number of hcc cases. biomarkers can help early detection and improve treatment regimen in patients as advanced stage is chemo-refractive with limited treatment options. potential of proteomics in finding new biomarkers for early det ... | 2017 | 28144394 |
| immunological and antiviral responses after therapeutic dna immunization in chronic hepatitis b patients efficiently treated by analogues. | a substudy of a phase i/ii, prospective, multicenter clinical trial was carried out to investigate the potential benefit of therapeutic vaccination on hepatitis b e antigen-negative patients with chronic hepatitis b (chb), treated efficiently with analogues. patients were randomized in 2 arms, one receiving a hepatitis b virus (hbv) envelope dna vaccine, and one without vaccination. at baseline, hbv-specific interferon (ifn)-γ-producing t cells were detected in both groups after in vitro expansi ... | 2014 | 28141993 |
| usefulness of humanized cdna-upa/scid mice for the study of hepatitis b virus and hepatitis c virus virology. | urokinase-type plasminogen activator-severe combined immunodeficiency (upa/scid) mice transplanted with human hepatocytes are permissive for hepatitis b virus (hbv) and hepatitis c virus (hcv) infection. however, one of the problems affecting upa transgenic mice is the expansion of mouse hepatocyte colonies due to homologous recombination of the upa gene. in this study, we attempted to infect hbv and hcv in humanized cdna-upa/scid mice, a novel upa transgenic mouse model designed to overcome thi ... | 2017 | 28141486 |
| antiviral therapies for managing viral hepatitis in lymphoma patients. | in patients with lymphoma the detection of positive hepatitis b or c viruses (hbv and hcv) serology involves crucial therapeutic consequences. in hbv-infected patients the serological profile of active (hbsag-positive) or resolved (hbsag-negative/anti-hbcab-positive) infection is associated to differential risk of viral reactivation during rituximab-based therapy and require appropriate strategies of monitoring and of antiviral prophylaxis. in hcv-associated nhl patients consolidated data demons ... | 2017 | 28140702 |
| comparative evaluation of long-term monotherapies & combination therapies in patients with chronic hepatitis b: a pilot study. | reduction of viraemia in patients with chronic hepatitis b virus (hbv) infection using nucleoside/nucleotide analogues reduces fatal liver disease-related events, but development of resistance in virus presents serious clinical challenge. therefore, comparative evaluation of prolonged antiviral monotherapy and combination therapies was prospectively studied to assess their influence on viral suppression, rapidity of response, development of drug resistance and surfacing mutants in chronic liver ... | 2016 | 28139541 |
| evaluating exosome protein content changes induced by virus activity using silac labeling and lc-ms/ms. | exosomes are small membrane vesicles that are produced by cells and excreted into extracellular space. contents of exosomes generally include lipid, membrane, and soluble proteins, and various types of coding and noncoding rnas. over the past decades, it has become clear that exosomes constitute an important vector for intercellular transport and communication with significant functional relevance. evaluating exosome contents and their changes are vital for understanding its role in different ph ... | 2017 | 28137563 |
| microrna-141 targets sirt1 and inhibits autophagy to reduce hbv replication. | about 400 million individuals are chronically infected with hepatitis b virus, at high risk of developing liver cirrhosis and hepatocellular carcinoma. recent studies have demonstrated an interaction between hepatitis b virus replication and autophagy activity of hepatocytes. in the present study, we aimed to investigate the role of mir-141 in regulating autophagy and hepatitis b virus replication. | 2017 | 28135713 |
| will infant hepatitis b vaccination protect into adulthood? extended canadian experience after a 2, 4, 6 month immunization schedule. | hepatitis b virus (hbv) vaccination programs generally target infants to prevent chronic hbv infection and/or pre-adolescents to reduce transmission in adulthood. to assess whether infant hbv immunization can potentially accomplish both objectives we measured residual immunity 10-16 years after vaccination in canadian children. | 2017 | 28134742 |
| [two cases of primary hepatic mucosa-associated lymphoid tissue(malt) lymphoma]. | case 1: a 57-year-old woman with chronic hepatitis related to the hepatitis b virus was found to have a liver tumor on ultrasonography(us). computed tomography(ct), magnetic resonance imaging(mri), and angiography revealed 2 tumors in the liver. the patient underwent right anterior sectorectomy, and histopathologic analysis revealed mucosa-associated lymphoid tissue(malt)lymphoma. thirty months later, recurrence was confirmed using liver biopsy. cr was confirmed after radiation and chemotherapy, ... | 2016 | 28133134 |
| immunomodulation by hyperimmunoglobulins after solid organ transplantation: beyond prevention of viral infection. | hyperimmunoglobulins are pharmaceutical formulations of human igg which contain high titers of antibodies against specific viruses. they have been successfully used in solid organ transplantation (sot) to prevent cytomegalovirus (cmv) and hepatitis b virus (hbv) infection. the introduction of effective and cheaper antiviral drugs has resulted in decreasing usage of hyperimmunoglobulins in sot. however, it may still be attractive to combine antiviral drug therapy with hyperimmunoglobulins after s ... | 2017 | 28131494 |
| a novel noninvasive algorithm for the assessment of liver fibrosis in patients with chronic hepatitis b virus infection. | several noninvasive blood biomarkers have been established for the assessment of liver fibrosis in patients with chronic hepatitis b virus (hbv) infection, but their clinical performance remains inconclusive. here, we compared the diagnostic performance of these biomarkers and developed a novel algorithm for assessing liver fibrosis. six hundred and sixteen chronically hbv-infected and treatment-naïve patients who underwent liver biopsy were enrolled and randomly divided into training (n=410) an ... | 2017 | 28130852 |
| hepatitis b surface antigen loss and clinical outcomes between hbeag-negative cirrhosis patients who discontinued or continued nucleoside analogue therapy. | we investigated the incidence and predictors of post-treatment hepatitis b virus (hbv) relapse and hepatitis b surface antigen (hbsag) loss. after cessation of nucleoside analogue (na) treatment in hepatitis b e antigen (hbeag)-negative patients with cirrhosis. the rates of hbsag loss and hepatocellular carcinoma (hcc) development in hbeag-negative patients with cirrhosis who continued na treatment were compared with those who discontinued treatment. patients with compensated cirrhosis who had d ... | 2017 | 28130815 |
| role of surface antibody in hepatitis b reactivation in patients with resolved infection and hematologic malignancy: a meta-analysis. | patients with resolved hepatitis b virus (hbv) infection who are treated for hematological malignancies remain at risk for hbv reactivation. because of conflicting studies about whether the antibody to hepatitis b surface antigen (anti-hbs) protects against reactivation in patients with resolved infection (hepatitis b surface antigen negative) receiving chemotherapy for hematological malignancies, we conducted a meta-analysis to determine if anti-hbs reduces hbv reactivation risk. we sought engl ... | 2017 | 28128861 |
| immunosuppression strategies in liver transplantation patient; patients with hepatocellular carcinoma. | hepatocellular carcinoma (hcc) consists the main primary malignant tumor of the liver. there is an underlining liver cirrhosis mainly attributed to chronic hepatitis b virus or hepatitis c virus, alcoholic liver disease, nonalcoholic steatohepatitis and other pathologic conditions. liver transplantation consists a radical management, treating both cancer and cirrhosis. by introducing the milan criteria for liver transplantation in hcc patients there was a 5-year survival escalation. even though ... | 2017 | 28128716 |
| regulatory responses during chronic hepatitis b virus infection. | 2017 | 28128469 | |
| microrna profile analysis in the liver fibrotic tissues of chronic hepatitis b patients. | the mirnas play an important role in the development of human fibrosis diseases. however, the mechanisms of mirna related to liver fibrosis are not fully exploited. our study aims to identify the mirnas features during fibrotic stage s0 to s4,which would be associated with hepatitis b virus (hbv) related liver fibrosis. | 2017 | 28127890 |
| phase iib trial of in vivo electroporation mediated dual-plasmid hepatitis b virus dna vaccine in chronic hepatitis b patients under lamivudine therapy. | to assess the efficacy and safety of in vivo electroporation (ep)-mediated dual-plasmid hepatitis b virus (hbv) dna vaccine vs placebo for sequential combination therapy with lamivudine (lam) in patients with chronic hepatitis b. | 2017 | 28127204 |
| 3-dimensional liver volume assessment in patients with hepatitis b virus-related liver cirrhosis during long-term oral nucleos(t)ide analogues therapy. | to assess the effect of long-term oral nucleos(t)ide analogues (nucs) therapy on liver volume change in patients with suppress hepatitis b virus (hbv)-related liver cirrhosis. | 2017 | 28127203 |
| association between polymorphisms of the apobec3g gene and chronic hepatitis b viral infection and hepatitis b virus-related hepatocellular carcinoma. | to determine the relationship between five a3g gene single nucleotide polymorphisms and the incidence of hepatitis b virus (hbv) infection and hepatocellular carcinoma (hcc). | 2017 | 28127197 |
| characterization of contrasting features between hepatitis b virus genotype a and genotype d in small envelope protein expression and surface antigen secretion. | hepatitis b virus (hbv) genotypes a and d are prevalent in many parts of the world and show overlapping geographic distributions. we amplified the entire hbv genome from sera of patients with genotypes a and d and generated overlength constructs for transient transfection into huh7 or hepg2 cells. genotype d clones were associated with less hbsag in culture supernatant and even less intracellular hbsag. they produced less 2.1-kb rna due to a weaker spii promoter. chimeric promoter constructs ide ... | 2017 | 28126637 |
| prevalence of and risk factors associated with cryptosporidium infection in an underdeveloped rural community of southwest china. | cryptosporidium spp. is an important intestinal protozoan causing diarrhea in humans, livestock, and wild animals. cryptosporidium infection remains a major public health issue, but its epidemiology in humans is still unclear, particularly in rural china. this study was designed to determine the prevalence of and risk factors associated with cryptosporidium infection in a rural southwestern chinese community. | 2017 | 28126012 |
| lack of ser267phe variant of sodium taurocholate cotransporting polypeptide among moroccans regardless of hepatitis b virus infection status. | the sodium taurocholate co-transporting polypeptide, encoded by slc10a1, was identified as a functional receptor for hepatitis b virus (hbv). the objective of this study was to determine if there was an association of the ser267phe variant (rs2296651) with hbv infection status in moroccan patients. | 2017 | 28125961 |
| n-glycosylation of the na+-taurocholate cotransporting polypeptide (ntcp) determines its trafficking and stability and is required for hepatitis b virus infection. | the sodium/bile acid cotransporter ntcp was recently identified as a receptor for hepatitis b virus (hbv). ntcp is glycosylated and the role of glycans in protein trafficking or viral receptor activity is not known. ntcp contains two n-linked glycosylation sites and asparagine amino acid residues n5 and n11 were mutated to a glutamine to generate ntcp with a single glycan (ntcp-n5q or ntcp- n11q) or no glycans (ntcp- n5,11q). hepg2 cells expressing ntcp with a single glycan supported hbv infecti ... | 2017 | 28125599 |
| [atypical serological profiles in hepatitis b infections: investigation of s gene mutations in cases with concurrently positive for hbsag and anti-hbs]. | hepatitis b virus (hbv) causes different clinical manifestations, ranging from asymptomatic carriage to fulminant or chronic hepatitis. serological tests are widely used for the diagnosis of hbv infections to detect viral markers. however, facing with atypical serological profiles in some patients leads to problems in interpreting of the results and management of the patients. the aims of this study were to investigate the atypical serologic profiles seen in patients screened for hbv infection a ... | 2016 | 28124958 |
| re-evaluation of glycated hemoglobin and glycated albumin with continuous glucose monitoring system as markers of glycemia in patients with liver cirrhosis. | liver cirrhosis (lc) is frequently accompanied by glucose intolerance. the present study was designed to determine whether glycated hemoglobin a1c (hba1c) and glycated albumin (ga) were predictive markers of glycemia, as determined by a continuous glucose monitoring system (cgms), in patients with lc. a total of 30 patients with lc, including 3, 19, 5, 2 and 1 with lc due to hepatitis b virus, hepatitis c virus, non-alcoholic steatohepatitis, alcohol and unknown causes, respectively, were assess ... | 2017 | 28123707 |
| adefovir dipivoxil-induced fanconi syndrome and its predictive factors: a study of 28 cases. | the aim of the present study was to identify monitoring and prevention measures as well as predictive factors for early detection of renal toxicity associated with long-term administration of adefovir dipivoxil in order to avoid progression to fanconi syndrome. clinical data of 28 patients with fanconi syndrome caused by long-term administration of adefovir dipivoxil for the treatment of chronic hepatitis b virus (hbv) infection were collected pre-and post-administration for analysis. patients p ... | 2017 | 28123560 |
| experimental studies on the inactivation of hbv in blood via riboflavin photochemical treatment. | the aim of the study was to examine the influence of riboflavin photochemical method on the inactivation of hepatitis b virus (hbv) and the functions of red blood cells. twenty patients suffering viral hepatitis b were selected in this study, and venous blood was collected and final concentration of 1,500 µmol/l riboflavin were added, to accept the λ=400-500 nm. the light intensity of 40,000 lux was treated with 2 h. the effect of inactivation was then evaluated and the function of red blood cel ... | 2017 | 28123493 |
| sero-prevalence of bloodborne tumor viruses (hcv, hbv, htlv-i and kshv infections) and related risk factors among prisoners in razavi khorasan province, iran, in 2008. | prisoners are at high risk of blood borne and sexually transmitted infections due to their high involvement in risky behaviors. in this descriptive/cross-sectional study, the prevalence, sero-prevalence, and risk factors for bloodborne tumor viruses including htlv-i, hbv, hcv, and kshv were evaluated among inmates of two central prisons in the northeast of iran. | 2016 | 28123439 |
| characteristics of pregnant women with hepatitis b virus infection in 5 us public health jurisdictions, 2008-2012. | we estimated the prevalence of hepatitis b surface antigen (hbsag), a serologic marker of active hepatitis b virus (hbv) infection, among pregnant women, and estimated the proportion hbsag-positive pregnant women who had received additional recommended testing. | 2016 | 28123209 |
| matrix metalloproteinase 9 facilitates hepatitis b virus replication through binding with type i interferon (ifn) receptor 1 to repress ifn/jak/stat signaling. | hepatitis b virus (hbv) infection may cause acute hepatitis b, chronic hepatitis b (chb), liver cirrhosis, and hepatocellular carcinoma (hcc). however, the mechanisms by which hbv evades host immunity and maintains chronic infection are largely unknown. here, we revealed that matrix metalloproteinase 9 (mmp-9) is activated in peripheral blood mononuclear cells (pbmcs) of hbv-infected patients, and hbv stimulates mmp-9 expression in macrophages and pbmcs isolated from healthy individuals. mmp-9 p ... | 2017 | 28122987 |
| clinico-pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases. | angiomyolipomas are rare neoplasms of mesenchymal origin and are derived from perivascular epithelioid cells. they usually develop in the kidney and rarely in the liver. due to their rarity, most hepatic angiomyolipomas have been misinterpreted as hepatocellular carcinoma (hcc) or other hypervascular liver tumours on imaging studies. we aimed to assess the clinico-pathological correlation of hepatic angiomyolipoma. | 2017 | 28122404 |
| effects of antiviral therapy on post-hepatectomy hbv reactivation and liver function in hbv dna-negative patients with hbv-related hepatocellular carcinoma. | the ability of antiviral therapy to reduce risk of post-hepatectomy hepatitis b virus (hbv) reactivation in patients negative for viral dna is unclear. this prospective study involved 174 consecutive patients with hepatitis b virus related hepatocellular carcinoma who were negative for hepatitis b virus dna in serum and who underwent hepatic resection. hepatitis b virus reactivation occurred in 30 patients in the non-antiviral group (27.8%) but in only 2 patients in the antiviral group (3.0%, p ... | 2017 | 28122361 |
| permissive, in vitro replication of hepatitis b virus genotype e. | a cloned stable cell line, hepg2-hbve6, was established following transfection of hepg2 cells with a retroviral plasmid into which a 1.1-fold genomic construct of hepatitis b virus (hbv) belonging to genotype e (hbv/e) was inserted. the cell line retains the entire hbv/e insert, and produces episomal hbv dna. it expresses hbv pregenomic, pres1 and pres2/s transcripts, and sheds hepatitis b surface and e antigens as well as structures resembling hbv-subviral and dane particles. the hepg2-hbve6 ce ... | 2017 | 28122202 |
| hepatitis delta and hiv infection. | viral liver diseases are frequent comorbidities and major contributors to death in hiv-positive individuals on antiretroviral therapy. although cure of hepatitis c and control of hepatitis b with antivirals avert liver disease progression in most hiv-coinfected patients, the lack of satisfactory treatment for hepatitis delta virus (hdv) infection remains a major threat for developing cirrhosis and liver cancer in this population. in the european union (eu) and north america, sexual contact has r ... | 2017 | 28121714 |
| seroepidemiology of hepatitis b and c virus infections among blood donors in ethiopia. | this study was conducted to investigate the prevalence of hepatitis b virus (hbv) and hepatitis c virus (hcv) infections among blood donors in different regions in ethiopia. a total of 56 885 sera were tested for hbsag and anti-hcv antibodies. of these, 3.9% were found hbsag-positive, 0.52% anti-hcv-positive, and 0.054% dual positive. hbv prevalence was relatively higher in adama (5.91%) than gondar (4.05%), jimma (3.87%), addis ababa (3.75%), and tigray (3.7%); and in males (4.64%) than females ... | 2017 | 28121005 |
| prevalence and the associated risk factors of hiv, stis and hbv among men who have sex with men in kunming, china. | to investigate the prevalence and the associated risk factors of human immunodeficiency virus (hiv), hepatitis b virus (hbv) and sexually transmitted infections (stis) among men who have sex with men (msm) in kunming, 300 msm were recruited through community-based organizations between september 2014 and january 2015. the prevalence of hiv, hbsag, syphilis, chlamydia trachomatis (ct) and neisseria gonorrhoeae (ng) were 17.0%, 7.7%, 11.3%, 18.2% and 13.2%, respectively. in the three different ana ... | 2017 | 28120646 |
| the prevalence of occult hepatitis b virus in the hemodialysis patients in yazd, iran. | occult hbv infection of hemodialysis (hd) patients is informative in terms of virus transmission. it may be of clinical importance in hd patients. the aim of this study was to investigate the prevalence of anti-hbc in the hd patients. number of 126 patients undergoing hemodialysis were included in this study from main hemodialysis units in yazd. hepatitis b surface antigens (hbsag), hepatitis b core antibody (anti-hbc) were examined in all subjects. finally, stored serum samples from anti-hbcab ... | 2016 | 28120590 |
| hepatitis b virus infection status and infertility causes in couples seeking fertility treatment-indicator of impaired immune response? | the relationship between hepatitis b (hbv) infection in infertile couples seeking in vitro fertilization (ivf) treatment and infertility causes is unknown. | 2017 | 28120470 |
| three-dimensional laparoscopic anatomical segment 8 liver resection with glissonian approach. | anatomical liver resection has been reported to have oncologic benefit over nonanatomical resection in surgery for hepatocellular carcinoma (hcc). basic concept of anatomical resection is preventing tumor spread through the portal or venous flow. few cases have been reported for laparoscopic anatomical segment 8 resection because of its technical difficulties. this video shows operative techniques for laparoscopic anatomical resection of segment 8, exposing middle and right hepatic vein and infe ... | 2017 | 28120133 |
| association between chronic hepatitis b virus infection and hla-dp gene polymorphisms in the turkish population. | hepatitis b virus (hbv) affects approximately 360 million people worldwide. 10-15% of patients with chronic hbv develop liver cirrhosis (lc), liver failure and hepatocellular carcinoma (hcc). chronic hbv infection or hbv clearance is influenced by both viral and host factors. in genome-wide association studies (gwas), the human leukocyte antigen (hla) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis b. hla genes have been linked to immune response t ... | 2017 | 28119119 |
| 15year fulminant hepatitis b follow-up in belgium: viral evolution and signature of demographic change. | fulminant hepatitis among different clinical outcomes of hepatitis b virus infection is very rare and manifests high mortality rate, however it has not been investigated in belgian inhabitants yet. in the frame of a retrospective study between 1995 and 2010, 80 serum samples (in some cases serial samples) archived in biobank, were collected from 24 patients who had clinically developed fulminant infection of hepatitis b virus. in total, 33 hepatitis b virus (hbv) strains (31 full-length genome a ... | 2017 | 28119028 |
| prevalence of hepatitis b and c and factors for infection and nonimmune in inflammatory bowel disease patients in china. | the aims of this study were to investigate the prevalence of hepatitis b virus (hbv) and hepatitis c virus (hcv) infection in inflammatory bowel disease (ibd) patients and the risk factors related to the infection and nonimmune status. | 2017 | 28118178 |
| research progress of therapeutic vaccines for treating chronic hepatitis b. | hepatitis b virus (hbv) is a member of hepadnavirus family, which leads to chronic infection in around 5% of patients with a high risk of developing liver cirrhosis, liver failure, and hepatocellular carcinoma. (1) despite the availability of prophylactic vaccines against hepatitis b for over 3 decades, there are still more than 2 billion people have been infected and 240 million of them were chronic. antiviral therapies currently used in the treatment of chb (chronic hepatitis b) infection incl ... | 2017 | 28118084 |
| nuclear import of hepatitis b virus capsids and genome. | hepatitis b virus (hbv) is an enveloped pararetrovirus with a dna genome, which is found in an up to 36 nm-measuring capsid. replication of the genome occurs via an rna intermediate, which is synthesized in the nucleus. the virus must have thus ways of transporting its dna genome into this compartment. this review summarizes the data on hepatitis b virus genome transport and correlates the finding to those from other viruses. | 2017 | 28117723 |
| control of hepatitis b virus by cytokines. | hepatitis b virus (hbv) infection remains a major public health problem worldwide with more than 240 million individuals chronically infected. current treatments can control hbv replication to a large extent, but cannot eliminate hbv infection. cytokines have been shown to control hbv replication and contribute to hbv cure in different models. cytokines play an important role in limiting acute hbv infection in patients and mediate a non-cytolytic clearance of the virus. in this review, we summar ... | 2017 | 28117695 |
| impact of universal infant hepatitis b vaccination in the us-affiliated pacific islands, 1985-2015. | the us-affiliated pacific island countries (usapi) is an endemic region for hepatitis b virus (hbv) infection. universal infant hepatitis b vaccination was introduced in the usapi in the mid-1980s to mitigate the hbv burden. we assessed the impact of universal infant vaccination on the hbv infection prevalence over time among children born in the 1980s, 1990s, and 2000s in the usapi. demographic and serologic data from serial sero-surveys conducted between 1985 and 2015 were obtained. descriptiv ... | 2017 | 28117171 |
| alanine aminotransferase is more sensitive to the decrease in hepatitis b virus-dna load than other liver markers in chronic hepatitis b patients. | a direct correlation between hepatitis b virus dna (hbv-dna) and liver markers has not been identified in chronic hepatitis b (chb) patients. however, the effect of hbv-dna changes on liver markers remains unclear. we explored the association between decreased hbv-dna and liver makers in chb patients. | 2017 | 28116822 |
| a survey of knowledge about hepatitis b among new military recruits in china. | hepatitis b is a disease that affects the liver and is caused by the hepatitis b virus (hbv). hepatitis b is a serious public health problem in china. the objective of this study was to assess knowledge of and behaviours towards the transmission and prevention of hepatitis b of new military recruits in china. | 2017 | 28116112 |
| treatment efficacy and safety of tenofovir-based therapy in chronic hepatitis b: a real life cohort study in korea. | we evaluated the efficacy and safety of tenofovir disoproxil fumarate (tdf)-based therapy in naïve and treatment-experienced chronic hepatitis b (chb) patients for 96 weeks in korean real life practice. | 2017 | 28114428 |
| multi-omics analyses reveal metabolic alterations regulated by hepatitis b virus core protein in hepatocellular carcinoma cells. | chronic hepatitis b virus (hbv) infection is partly responsible for hepatitis, fatty liver disease and hepatocellular carcinoma (hcc). hbv core protein (hbc), encoded by the hbv genome, may play a significant role in hbv life cycle. however, the function of hbc in the occurrence and development of liver disease is still unclear. to investigate the underlying mechanisms, hbc-transfected hcc cells were characterized by multi-omics analyses. combining proteomics and metabolomics analyses, our resul ... | 2017 | 28112229 |
| kidney disease in hepatitis b surface antigen-positive children: experience from a centre in south-west nigeria and a review of the nigerian literature. | kidney disease is an important extra-hepatic manifestation of hepatitis b virus (hbv) infection. however, there is paucity of recent literature on kidney disease in children and adolescents with hbv infection from several parts of sub-saharan africa including nigeria. | 2017 | 28112049 |
| portal vein thrombosis in patients with cirrhosis undergoing elective transjugular intrahepatic portosystemic shunt. | portal vein thrombosis (pvt) is a common complication in cirrhosis. the aim of this study was to determine risk factors for pvt, assess the efficacy of anticoagulant therapy, and evaluate the effects of pvt on patients with cirrhosis undergoing elective transjugular intrahepatic portosystemic shunt (tipss). a total of 101 patients with cirrhosis undergoing elective tipss were prospectively studied. after tipss, all patients received preventive therapy for pvt and were followed up at 3, 6, 12, an ... | 2017 | 28110540 |
| immune regulation by t regulatory cells in hepatitis b virus-related inflammation and cancer. | hepatocellular carcinoma (hcc) is the leading cause of cancer death, and hepatitis b virus (hbv) infection is one of the commonest causes in asian countries. india has the second largest pool after china for hepatitis b-infected subjects. hbv clearance is t cell dependent, and one of the reasons for t cells hyporesponsiveness is due to mass production of regulatory t cells (tregs) through activation of notch signalling, which suppress cd4/cd8 t cells. tregs are important to maintain cellular hom ... | 2017 | 28109025 |
| paired assessment of liver telomere lengths in hepatocellular cancer is a reliable predictor of disease persistence. | in the present study, we used a small series of highly defined patients, where we had matched timed peripheral blood samples (pbs), as well as paired liver biopsies obtained during collection of blood samples from patients with diagnosed hepatocellular carcinoma (hcc) and compared the correlation between the changes of telomere lengths in these defined samples. patients included had either hcc alone or in conjunction with either pre-existing hepatitis b virus (hbv) or hepatitis c virus (hcv) inf ... | 2017 | 28108675 |
| development of amino functionalized carbon coated magnetic nanoparticles and their application to electrochemical detection of hybridization of nucleic acids. | in our study, the development of amino functionalized carbon coated magnetic nanoparticles (nh2-cc-mnps) and their usage for electrochemical detection of hybridization of nucleic acids have been aimed. firstly, nh2-cc-mnps were prepared by coating of pristine fe3o4 nanoparticles with two layers via caramelization and silanization processes respectively. after the morphological characterization with scanning electron microscopy (sem) it was seen that nh2-cc-mnps was spherical shaped and in 28nm s ... | 2017 | 28107914 |
| epidemiology update for hepatitis c virus and hepatitis b virus in end-stage renal disease in france. | risk for hcv/hbv infection is increased in end-stage renal disease patients. we generate updated epidemiological data. | 2017 | 28107607 |
| predictors of liver histological changes and a sustained virological response to peginterferon among chronic hepatitis b e antigen-positive patients with normal or minimally elevated alanine aminotransferase levels. | a proportion of chronic hepatitis b patients with normal or only minimally elevated alanine aminotransferase (alt) levels display significant histologic changes and would benefit from antiviral therapy. we aim to evaluate the histologic abnormalities seen in these patients and then determine which of them would most likely respond to peginterferon therapy. one hundred and thirteen hepatitis b e antigen (hbeag)-positive patients with a normal or minimally elevated alt level and moderate-to-severe ... | 2017 | 28107601 |
| validation of a modified child-turcotte-pugh classification system utilizing insulin-like growth factor-1 for patients with hepatocellular carcinoma in an hbv endemic area. | recently, a modified insulin-like growth factor-1 (igf)-child-turcotte-pugh (ctp) classification was proposed to improve the original ctp classification. this study aimed to validate the new igf-ctp classification system as a prognostic maker for patients with hepatocellular carcinoma (hcc) in a hepatitis b virus endemic area. | 2017 | 28107416 |
| charm: discovery of combinatorial chromatin modification patterns in hepatitis b virus x-transformed mouse liver cancer using association rule mining. | various chromatin modifications, identified in large-scale epigenomic analyses, are associated with distinct phenotypes of different cells and disease phases. to improve our understanding of these variations, many computational methods have been developed to discover novel sites and cell-specific chromatin modifications. despite the availability of existing methods, there is still room for further improvement when they are applied to resolve the histone code hypothesis. hence, we aim to investig ... | 2016 | 28105934 |
| efficacy and safety of tenofovir in chronic hepatitis b: australian real world experience. | to evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world australian tertiary care setting. | 2017 | 28105258 |
| hepatic resection versus transarterial chemoembolization for patients with barcelona clinic liver cancer intermediate stage child-pugh a hepatocellular carcinoma. | the present study aimed to compare the overall and recurrence-free survival rates following hepatic resection (hr) and transcatheter arterial chemoembolization (tace) in patients with barcelona clinic liver cancer (bclc) classified intermediate-stage child-pugh a hepatocellular carcinoma (hcc). a total of 443 patients were examined, among whom 274 underwent hr, whereas 169 received tace. the overall survival, recurrence-free survival between groups and subgroups, and risk factors with respect to ... | 2016 | 28105115 |
| cutting balloon treatment of anastomotic biliary stenosis after liver transplantation: report of two cases. | biliary stenosis is a common complication after liver transplantation, and has an incidence rate ranging from 4.7% to 12.5% based on our previous study. three types of biliary stenosis (anastomotic stenosis, non-anastomotic peripheral stenosis and non-anastomotic central hilar stenosis) have been identified. we report the outcome of two patients with anastomotic stricture after liver transplantation who underwent successful cutting balloon treatment. case 1 was a 40-year-old male transplanted du ... | 2017 | 28104994 |
| pancreas transplantation after liver transplantation: a case report. | our aim was to describe the clinical indications, surgical technique, and clinical outcomes of a pancreas transplantation, performed 4 years after liver transplantation, as treatment for new-onset, uncontrolled diabetes mellitus in a 53-year-old man. liver transplantation was performed for end-stage liver disease secondary to hepatitis b virus infection and hepatocellular carcinoma. the patient had no history of diabetes prior to the liver transplantation. the decision to proceed with a pancreas ... | 2017 | 28104144 |
| recurrent hepatitis b and d virus infection in a liver transplant recipient. | hepatitis b virus (hbv) and hepatitis delta virus (hdv) co-infections progress rapidly and lead to cirrhosis. in japan, the prevalence of hbv and hdv co-infected patients is low. therefore, there are few reports of patients with hbv and hdv co-infection having undergone liver transplantation. herein, we report a rare case of recurrence of hbv and hdv in a 41-year-old man who underwent living donor liver transplantation 4 years prior. | 2017 | 28104130 |
| telbivudine versus entecavir in patients with undetectable hepatitis b virus dna: a randomized trial. | telbivudine has been suggested to induce hepatitis b surface antigen (hbsag) decline to the similar degree as pegylated interferon. we aimed to investigate whether telbivudine could further decrease hbsag titer in patients who maintain undetectable serum hepatitis b virus (hbv) dna after initial entecavir treatment. | 2017 | 28103819 |
| hbxip, a binding protein of hbx, regulates maintenance of the g2/m phase checkpoint induced by dna damage and enhances sensitivity to doxorubicin-induced cytotoxicity. | to maintain the integrity of the genome, cells need to detect and repair dna damage before they complete cell division. hepatitis b x-interacting protein (hbxip), a binding protein of hbx (hepatitis b virus × protein), is aberrantly overexpressed in human cancer cells and show to promote cell proliferation and inhibit apoptosis. the present study is designed to investigate the role of hbxip on the dna damage response. our results show that hbxip acts as an important regulator of g2/m checkpoint ... | 2017 | 28103177 |
| a community-based randomized trial of hepatitis b screening among high-risk vietnamese americans. | to evaluate the effectiveness of a community-based liver cancer prevention program on hepatitis b virus (hbv) screening among low-income, underserved vietnamese americans at high risk. | 2017 | 28103075 |
| hepatitis b virus x protein promotes the stem-like properties of ov6(+) cancer cells in hepatocellular carcinoma. | hepatitis b virus x protein (hbx) and cancer stem-like cells (cscs) have both been implicated in the occurrence and development of hbv-related hepatocellular carcinoma (hcc). however, whether hbx contributes to the stem-like properties of ov6(+) cscs in hcc remains elusive. in this study, we showed that the concomitant expression of hbx and ov6 was closely associated with the clinical outcomes and prognosis of patients with hbv-related hcc. hbx was required for the stem-like properties of ov6(+) ... | 2017 | 28102846 |
| farnesoid x receptor ablation sensitizes mice to hepatitis b virus x protein-induced hepatocarcinogenesis. | chronic hepatitis b virus infection is a major risk factor for hepatocellular carcinoma (hcc). hepatitis b virus x protein (hbx) is a hepatitis b virus protein that has multiple cellular functions, but its role in hcc pathogenesis has been controversial. farnesoid x receptor (fxr) is a nuclear receptor with activities in anti-inflammation and inhibition of hepatocarcinogenesis. however, whether or how fxr can impact hepatitis b virus/hbx-induced hepatocarcinogenesis remains unclear. in this stud ... | 2017 | 28102638 |
| bone health in hiv and hepatitis b or c infections. | chronic infections with human immunodeficiency virus (hiv), hepatitis b virus (hbv) or hepatitis c virus (hcv) add to age-dependent bone loss and may contribute to lower bone strength in the elderly. in this review, we report recent highlights on the epidemiology of bone fragility in chronic viral infections with hiv, hcv and hbv, its physiopathology and discuss the interference of antiviral therapies with bone metabolism. chronic infections influence bone through the interactions between risk f ... | 2017 | 28101146 |