Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| identification of plasmodium spp. in neotropical primates of maranhense amazon in northeast brazil. | in the brazilian amazon region, malaria caused by plasmodium malariae is considered to be a zoonosis because of cross-transfer of the parasite between humans and neotropical primates. to contribute information on this issue, we investigated occurrences of natural infection with plasmodium sp. among neotropical primates in the maranhense amazon (amazon region of the state of maranhão), in the northeastern region of brazil. blood samples were collected from 161 neotropical primates of six species ... | 2017 | 28796820 |
| cortical control of object-specific grasp relies on adjustments of both activity and effective connectivity: a common marmoset study. | the cortical mechanisms of grasping have been extensively studied in macaques and humans; here, we investigated whether common marmosets could rely on similar mechanisms despite strong differences in hand morphology and grip diversity. we recorded electrocorticographic activity over the sensorimotor cortex of two common marmosets during the execution of different grip types, which allowed us to study cortical activity (power spectrum) and physiologically inferred connectivity (phase-slope index) ... | 2017 | 28791721 |
| cross-species comparison of behavioral neurodevelopmental milestones in the common marmoset monkey and human child. | the common marmoset (callithrix jacchus) is an increasingly popular non-human primate species for developing transgenic and genomic edited models of neurological disorders. these models present an opportunity to assess from birth the impact of genetic mutations and to identify candidate predictive biomarkers of early disease onset. in order to apply findings from marmosets to humans, a cross-species comparison of typical development is essential. aiming to identify similarities, differences, and ... | 2017 | 28763098 |
| progesterone hydroxylation by cytochromes p450 2c and 3a enzymes in marmoset liver microsomes. | 1. common marmosets (callithrix jacchus) are potentially useful nonhuman primate models for preclinical drug metabolism studies. however, the roles of marmoset cytochrome p450 (p450) isoforms in the oxidation of endobiotic progesterone have not been fully investigated. in this study, the roles of marmoset p450 isoforms in progesterone hydroxylation were extensively determined. 2. the activities of liver microsomes from individual marmosets with respect to progesterone 21/17α- and 16α/6β-hydroxyl ... | 2017 | 28762864 |
| assessment of behavioural deficits following ischaemic stroke in the marmoset. | stroke is a common and devastating disease worldwide. over the last two decades, many therapeutic approaches to ameliorate ischaemic stroke have been promising in animal studies but failed when transferred to the clinical situation. one of the possible explanations for these failures is the widespread use of animal models of cerebral ischemia that do not mimic the pathology encountered in the clinic. accordingly, many expert committees recommended the integration of higher order species such as ... | 2017 | 28760698 |
| identification and characterization of the tyrosinase gene (tyr) and its transcript variants (tyr_1 and tyr_2) in the crab-eating macaque (macaca fascicularis). | tyrosinase is a copper-containing enzyme that regulates melanin biosynthesis and is encoded by the tyrosinase (tyr) gene. previous studies demonstrated that mutations in tyr could lead to oculocutaneous albinism type 1 (oca1) owing to the failure of melanin formation. although a previous study found that albinism in the rhesus monkey was derived from a mutation in tyr, the identification and characterization of this gene in non-human primates has not been achieved thus far. thus, using the rapid ... | 2017 | 28756020 |
| a b cell-driven autoimmune pathway leading to pathological hallmarks of progressive multiple sclerosis in the marmoset experimental autoimmune encephalomyelitis model. | the absence of pathological hallmarks of progressive multiple sclerosis (ms) in commonly used rodent models of experimental autoimmune encephalomyelitis (eae) hinders the development of adequate treatments for progressive disease. work reviewed here shows that such hallmarks are present in the eae model in marmoset monkeys (callithrix jacchus). the minimal requirement for induction of progressive ms pathology is immunization with a synthetic peptide representing residues 34-56 from human myelin ... | 2017 | 28744286 |
| non-human primates as a model for aging. | there has been, and continues to be, a dramatic shift in the human population towards older ages necessitating biomedical research aimed at better understanding the basic biology of aging and age-related diseases and facilitating new and improved therapeutic options. as it is not practical to perform the breadth of this research in humans, animal models are necessary to recapitulate the complexity of the aging environment. the mouse model is most frequently chosen for these endeavors, however, t ... | 2017 | 28729086 |
| utah optrode array customization using stereotactic brain atlases and 3-d cad modeling for optogenetic neocortical interrogation in small rodents and nonhuman primates. | as the optogenetic field expands, the need for precise targeting of neocortical circuits only grows more crucial. this work demonstrates a technique for using solidworks(®) computer-aided design (cad) and readily available stereotactic brain atlases to create a three-dimensional (3-d) model of the dorsal region of area visual cortex 4 (v4d) of the macaque monkey (macaca fascicularis) visual cortex. the 3-d cad model of the brain was used to customize an [formula: see text] utah optrode array (uo ... | 2017 | 28721358 |
| three-dimensional kinematic and kinetic analysis of quadrupedal walking in the common marmoset (callithrix jacchus). | the common marmoset has recently gained a great deal of attention as an experimental primate model for biological science and medical research. to use the common marmoset for development of novel treatments and rehabilitation for locomotor disorders, it is crucial to understand fundamental baseline characteristics of locomotion in this species. therefore, in the present study we performed kinematic and kinetic analyses of quadrupedal locomotion in this animal. a total of 14 common marmosets walk ... | 2017 | 28711711 |
| a technological framework for running and analyzing animal head turning experiments. | head turning experiments are widely used to test the cognition of both human infants and non-human animal species. monitoring head turns allows researchers to non-invasively assess attention to acoustic or visual stimuli. in the majority of head turning experiments, the head direction analyses have been accomplished manually, which is extremely labor intensive and can be affected by subjectivity or other human errors and limitations. in the current study, we introduce an open-source computer pro ... | 2017 | 28710717 |
| marmoset pulmonary cytochrome p450 2f1 oxidizes biphenyl and 7-ethoxycoumarin and hepatic human p450 substrates. | 1. a potentially useful animal model for preclinical studies is the common marmoset (callithrix jacchus). in this study, using reverse-transcription polymerase chain reaction from marmoset livers, we identified a novel cytochrome p450 (p450) 2f1 cdna with an open reading frame of 1473 bp. 2. high sequence identities of 92-94% with primate p450 2 f amino acid sequences were indicated by deduced amino acid sequences of p450 2f1 cdna. phylogenetic analysis indicates that marmoset p450 2f1 is more c ... | 2017 | 28689458 |
| effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome p450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome p450 2c19. | 1. the pharmacokinetics were investigated for human cytochrome p450 probes after single intravenous and oral administrations of 0.20 and 1.0 mg/kg, respectively, of caffeine, warfarin, omeprazole, metoprolol and midazolam to aged (10-14 years old, n = 4) or rifampicin-treated/young (3 years old, n = 3) male common marmosets all genotyped as heterozygous for a cytochrome p450 2c19 variant. 2. slopes of the plasma concentration-time curves after intravenous administration of warfarin and midazolam ... | 2017 | 28686070 |
| extra-ovarian gonadotropin negative feedback revealed by aromatase inhibition in female marmoset monkeys. | while the ovary produces the majority of estradiol (e2) in mature female primates, extra-ovarian sources contribute to e2 synthesis and action, including brain e2 regulating hypothalamic gonadotropin-releasing hormone (gnrh). in ovary-intact female rodent models, aromatase inhibition (ai) induces a pcos-like hypergonadotropic hyperandrogenism due to absent e2-mediated negative feedback. in order to examine the role of extra-ovarian e2 on nonhuman primate gonadotropin regulation, the present stud ... | 2017 | 28679622 |
| occurrence of hemotropic mycoplasmas in non-human primates (alouatta caraya, sapajus nigritus and callithrix jacchus) of southern brazil. | hemoplasmas, the erythrocyte-associated mycoplasmas, have been detected in several primates, causing mostly subclinical infection. this study aimed to determine the prevalence of hemoplasma infection in captive and free-ranging monkeys from southern brazil, as well as factors and hematological abnormalities associated with infection. blood samples from 40 non-human primates (nhp) were tested for hemoplasmas and coinfections. an overall of 10/40 (25.0%) nhp tested positive for hemoplasmas using p ... | 2017 | 28673463 |
| hepatic expression of cytochrome p450 enzymes in non-human primate species. | cytochromes p450 (p450) largely remain to be characterized in great apes. comparative immunochemical detection of drug metabolizing forms of p450s 1a, 2a, 2b, 2c, 2d, 2e, 2j, 3a, 4a, and 4f in liver microsomes from chimpanzees, gorillas, orangutans, gibbons, cynomolgus and rhesus macaques, and common marmosets were carried out. | 2017 | 28664555 |
| computed tomography of the abdomen in eight clinically normal common marmosets (callithrix jacchus). | the aim of this study was to provide a detailed anatomical description of the abdomen in the clinically normal common marmoset by means of computed tomography (ct). eight clinically healthy mature common marmosets ranging from 12 to 48 months and 235 to 365 g bodyweight were anesthetized and pre- and post-contrast ct examinations were performed using different ct settings in dorsal recumbency. abdominal organs were identified and visibility noted. diagnostic quality abdominal images could be obt ... | 2017 | 28653415 |
| induced pluripotent stem cell-derived dopaminergic neurons from adult common marmoset fibroblasts. | the common marmoset monkey (callithrix jacchus; cj) is an advantageous nonhuman primate species for modeling age-related disorders, including parkinson's disease, due to their shorter life span compared to macaques. cj-derived induced pluripotent stem cells (cj-ipscs) from somatic cells are needed for in vitro disease modeling and testing regenerative medicine approaches. here we report the development of a novel cj-ipsc line derived from adult marmoset fibroblasts. the cj-ipscs showed potent pl ... | 2017 | 28635509 |
| representations of time-varying cochlear implant stimulation in auditory cortex of awake marmosets (callithrix jacchus). | electrical stimulation of the auditory periphery organ by cochlear implant (ci) generates highly synchronized inputs to the auditory system. it has long been thought such inputs would lead to highly synchronized neural firing along the ascending auditory pathway. however, neurophysiological studies with hearing animals have shown that the central auditory system progressively converts temporal representations of time-varying sounds to firing rate-based representations. it is not clear whether th ... | 2017 | 28634306 |
| the effect of infant vocalization in alloparental responsiveness of common marmosets (callithrix jacchus). | among mammals, alloparental care can be influenced by hormones as well as by previous experience and sensory stimuli from the infants, such as sight and sound, smell, and physical contact with the infant. to determine the responsiveness of common marmoset (callithrix jacchus) nonreproductive females and males with and without previous experience in caretaking to infant sensory cues, we exposed 12 females and 12 males to vocalization recordings for 10 min under two conditions: (1) exposure to adu ... | 2017 | 28631840 |
| diffusion-weighted tractography in the common marmoset monkey at 9.4t. | the common marmoset (callithrix jacchus) is a small new world primate that is becoming increasingly popular in the neurosciences as an animal model of preclinical human disease. with several major disorders characterized by alterations in neural white matter (e.g., multiple sclerosis, alzheimer's disease, schizophrenia), proposed to be transgenically modeled using marmosets, the ability to isolate and characterize reliably major white matter fiber tracts with mri will be of use for evaluating st ... | 2017 | 28615334 |
| visual discrimination and reversal learning in aged common marmosets (callithrix jacchus). | common marmosets (callithrix jacchus) have been suggested as a new model for analysis of age-related changes and neurodegenerative diseases. however, the effects of age on learning and memory processes are not well defined within this species. therefore, we employed visual discrimination and reversal learning tasks to evaluate learning and memory in four aged common marmosets relative to a younger cohort. we found that aged marmosets commit significantly more errors in initial stages of visual d ... | 2017 | 28602996 |
| targeted patching and dendritic ca(2+) imaging in nonhuman primate brain in vivo. | nonhuman primates provide an important model not only for understanding human brain but also for translational research in neurological and psychiatric disorders. however, many high-resolution techniques for recording neural activity in vivo that were initially established for rodents have not been yet applied to the nonhuman primate brain. here, we introduce a combination of two-photon targeted patching and dendritic ca(2+) imaging to the neocortex of adult common marmoset, an invaluable primat ... | 2017 | 28588297 |
| an eye tracking system for monitoring face scanning patterns reveals the enhancing effect of oxytocin on eye contact in common marmosets. | eye tracking systems are used to investigate eyes position and gaze patterns presumed as eye contact in humans. eye contact is a useful biomarker of social communication and known to be deficient in patients with autism spectrum disorders (asds). interestingly, the same eye tracking systems have been used to directly compare face scanning patterns in some non-human primates to those in human. thus, eye tracking is expected to be a useful translational technique for investigating not only social ... | 2017 | 28586711 |
| experimental models of autoimmune demyelinating diseases in nonhuman primates. | human idiopathic inflammatory demyelinating diseases (iidd) are a heterogeneous group of autoimmune inflammatory and demyelinating disorders of the central nervous system (cns). these include multiple sclerosis (ms), the most common chronic iidd, but also rarer disorders such as acute disseminated encephalomyelitis (adem) and neuromyelitis optica (nmo). great efforts have been made to understand the pathophysiology of ms, leading to the development of a few effective treatments. nonetheless, iid ... | 2017 | 28583039 |
| relationship between immunoglobulin deposition and early lesions of progressive glomerulonephropathy in young common marmosets. | the authors previously investigated progressive glomerulonephropathy in 2- to 11-year-old common marmosets and characterized age-related changes of the renal glomeruli and development of tubulointerstitial lesions. in this study, immunoglobulin deposition and ultrastructural changes of the glomeruli were investigated in 5 young marmosets from 6 months to 3 years of age with pre-onset or early glomerulonephropathy. in all animals, the foot processes of podocytes were effaced, and igm was deposite ... | 2017 | 28578628 |
| 3d reconstruction of brain section images for creating axonal projection maps in marmosets. | the brain of the common marmoset (callithrix jacchus) is becoming a popular non-human primate model in neuroscience research. because its brain fiber connectivity is still poorly understood, it is necessary to collect and present connection and trajectory data using tracers to establish a marmoset brain connectivity database. | 2017 | 28577985 |
| faecal transplantation for the treatment of clostridium difficile infection in a marmoset. | the common marmoset has been used as an experimental animal for various purposes. because its average weight ranges from 250 to 500 g, weight loss quickly becomes critical for sick animals. therefore, effective and non-stressful treatment for chronic diseases, including diarrhoea, is essential. | 2017 | 28569200 |
| naturally occurring and experimentally induced β-amyloid deposits in the brains of marmosets (callithrix jacchus). | cerebral β-amyloid occurs in elderly animals of some species and in alzheimer's disease. previously, we injected 3 young marmosets intracerebrally with brain tissue from a patient with alzheimer's disease. six years later, when the monkeys were middle aged, we found moderate numbers of intracerebral plaques and cerebrovascular deposits containing β-amyloid. we have re-examined these brains and those of 10 other marmosets injected with brain homogenate containing β-amyloid, and have found some β- ... | 2000 | 28567518 |
| vocal learning via social reinforcement by infant marmoset monkeys. | for over half a century now, primate vocalizations have been thought to undergo little or no experience-dependent acoustic changes during development [1]. if any changes are apparent, then they are routinely (and quite reasonably) attributed to the passive consequences of growth. indeed, previous experiments on squirrel monkeys and macaque monkeys showed that social isolation [2, 3], deafness [2], cross-fostering [4] and parental absence [5] have little or no effect on vocal development. here, w ... | 2017 | 28552359 |
| hunger enhances consistent economic choices in non-human primates. | hunger and thirst are fundamental biological processes that drive consumption behavior in humans and non-human animals. while the existing literature in neuroscience suggests that these satiety states change how consumable rewards are represented in the brain, it remains unclear as to how they change animal choice behavior and the underlying economic preferences. here, i used combined techniques from experimental economics, psychology, and neuroscience to measure food preferences of marmoset mon ... | 2017 | 28539584 |
| altered detrusor contractility in mptp-treated common marmosets with bladder hyperreflexia. | bladder hyperreflexia is a common non-motor feature of parkinson's disease. we now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following mptp, the amplitude and frequency of spontaneous contraction was increased. these responses were unaffected by dopamine d1 and d2 receptor agonists a77636 and ropinirole respectively. contractions by exogenous carbachol, histamine or atp were similar and no differences in the magnitude of noradrenaline ... | 2017 | 28520722 |
| oxidative injury and iron redistribution are pathological hallmarks of marmoset experimental autoimmune encephalomyelitis. | oxidative damage and iron redistribution are associated with the pathogenesis and progression of multiple sclerosis (ms), but these aspects are not entirely replicated in rodent experimental autoimmune encephalomyelitis (eae) models. here, we report that oxidative burst and injury as well as redistribution of iron are hallmarks of the ms-like pathology in the eae model in the common marmoset. active lesions in the marmoset eae brain display increased expression of nicotinamide adenine dinucleoti ... | 2017 | 28505283 |
| a geometrically adjustable receive array for imaging marmoset cohorts. | the common marmoset (callithrix jacchus) is an increasingly popular animal model for translational neuroscience studies, during which anatomical and functional mri can be useful investigative tools. to attain the requisite snr for high-resolution acquisitions, the radiofrequency coil must be optimized for the marmoset; however, relatively few custom coils have been developed that maximize snr and are compatible with accelerated acquisitions. for the study of large populations of animals, the het ... | 2017 | 28499849 |
| regio- and stereo-selective oxidation of a cardiovascular drug, metoprolol, mediated by cytochrome p450 2d and 3a enzymes in marmoset livers. | a β-blocker, metoprolol, is one of the in vivo probes for human cytochrome p450 (p450) 2d6. investigation of nonhuman primate p450 enzymes helps to improve the accuracy of the extrapolation of pharmacokinetic data from animals into humans. common marmosets (callithrix jacchus) are a potential primate model for preclinical research, but the detailed roles of marmoset p450 enzymes in metoprolol oxidation remain unknown. in this study, regio- and stereo-selectivity of metoprolol oxidations by a var ... | 2017 | 28495902 |
| non-human primate orthologues of tmprss2 cleave and activate the influenza virus hemagglutinin. | the cellular serine protease tmprss2, a member of the type ii transmembrane serine protease (ttsp) family, cleaves and activates the hemagglutinin of influenza a viruses (fluav) in cell culture and is essential for spread of diverse fluav in mice. non-human primates (nhp), in particular rhesus and cynomolgus macaques, serve as animal models for influenza and experimental fluav infection of common marmosets has recently also been reported. however, it is currently unknown whether the nhp ortholog ... | 2017 | 28493964 |
| molecular cloning and characterization of marmoset aldehyde oxidase. | common marmosets (callithrix jacchus), new world monkeys, are a promising primate model for preclinical drug metabolism studies because of the similarities of cytochrome p450 (p450) enzyme function to those of humans. despite an increasing number of drug candidates catalyzed by non-p450 enzymes, drug metabolizing enzymes other than p450s have been hardly identified or characterized in marmosets. in this study, we identified aldehyde oxidase (aox) 1 gene by marmoset genome analysis. aox1 cdna was ... | 2017 | 28487309 |
| muscle architectural properties in the common marmoset (callithrix jacchus). | the common marmoset, callithrix jacchus, is a small new world monkey that has recently gained attention as an important experimental animal model in the field of neuroscience as well in rehabilitative and regenerative medicine. this attention reflects the closer phylogenetic relationship between humans and common marmosets compared to that between humans and other experimental animals. when studying the neuronal mechanism behind various types of neurological motor disorders using the common marm ... | 2017 | 28484857 |
| functional characterization and tissue expression of marmoset cytochrome p450 2e1. | common marmosets (callithrix jacchus) have attracted increasing attention as a useful small non-human primate model in preclinical research. however, studies on marmoset cytochrome p450 (p450) 2e enzyme have scarcely been conducted. in this study, the full-length cdna encoding p450 2e1 enzyme was isolated from marmoset livers by reverse transcription (rt)-polymerase chain reaction (pcr). marmoset p450 2e1 amino acid sequences were highly identical (>88%) to those of cynomolgus monkey and human p ... | 2017 | 28474789 |
| human neutralizing monoclonal antibody efficiently inhibits mers-cov replication in common marmoset. | middle east respiratory syndrome coronavirus (mers-cov) infection in humans is highly lethal, with a fatality rate of 35%. new prophylactic and therapeutic strategies to combat human infections are urgently needed. we isolated a fully human neutralizing antibody, mca1, from a human survivor. the antibody recognizes the receptor-binding domain of mers-cov s glycoprotein and interferes with the interaction between viral s and the human cellular receptor human dipeptidyl peptidase 4 (dpp4). to our ... | 2017 | 28472421 |
| detection of mycobacterium avium subsp. paratuberculosis in non-human primates. | due to a sporadic occurrence of mycobacterium avium subsp. paratuberculosis (map) in non-human primates (nhp), the susceptibility of different nhp to map should be investigated. | 2017 | 28444886 |
| trialling nutrient recommendations for slow lorises (nycticebus spp.) based on wild feeding ecology. | slow loris (nycticebus spp.) captive diets have been based on routine and anecdotes rather than scientific fact. the growing body of evidence contradicts the high fruit diet supported by such anecdotes. non-human primate nutrient requirements are grouped into new (based on the common marmoset callithrix jacchus) or old world (based on rhesus macaques macaca mulatta) primates. slow lorises are known to suffer from many health ailments in captivity such as dental disease, obesity, wasting and kidn ... | 2017 | 28444791 |
| terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome p450 3a and 4f enzymes in livers and small intestines. | 1. roles of human cytochrome p450 (p450) 3a4 in oxidation of an antihistaminic drug terfenadine have been previously investigated in association with terfenadine-ketoconazole interaction. several antihistamine drugs have been recently identified as substrates for multiple p450 enzymes. in this study, overall roles of p450 3a4, 2j2, and 4f12 enzymes in terfenadine t-butyl hydroxylation were investigated in small intestines and livers from humans, marmosets, and/or cynomolgus monkeys. 2. human liv ... | 2017 | 28436281 |
| common marmoset (callithrix jacchus) as a primate model for behavioral neuroscience studies. | the common marmoset (callithrix jacchus) has been proposed as a suitable bridge between rodents and larger primates. they have been used in several types of research including auditory, vocal, visual, pharmacological and genetics studies. however, marmosets have not been used as much for behavioral studies. | 2017 | 28400103 |
| efficacy of antibody-based therapies against middle east respiratory syndrome coronavirus (mers-cov) in common marmosets. | cases of middle east respiratory syndrome coronavirus (mers-cov) continue to be identified and with a lack of effective clinical treatment and no preventative strategies, treatment using convalescent plasma or monoclonal antibodies (mabs) is a potential quick route to an intervention. passive immunotherapy via either convalescent plasma or mabs has proven to be effective for other infectious agents. following infection with mers-cov, common marmosets were treated with high titer hyperimmune plas ... | 2017 | 28389142 |
| transgenic monkey model of the polyglutamine diseases recapitulating progressive neurological symptoms. | age-associated neurodegenerative diseases, such as alzheimer's disease, parkinson's disease, and the polyglutamine (polyq) diseases, are becoming prevalent as a consequence of elongation of the human lifespan. although various rodent models have been developed to study and overcome these diseases, they have limitations in their translational research utility owing to differences from humans in brain structure and function and in drug metabolism. here, we generated a transgenic marmoset model of ... | 2017 | 28374014 |
| representation of glossy material surface in ventral superior temporal sulcal area of common marmosets. | the common marmoset (callithrix jacchus) is one of the smallest species of primates, with high visual recognition abilities that allow them to judge the identity and quality of food and objects in their environment. to address the cortical processing of visual information related to material surface features in marmosets, we presented a set of stimuli that have identical three-dimensional shapes (bone, torus or amorphous) but different material appearances (ceramic, glass, fur, leather, metal, s ... | 2017 | 28367117 |
| convergent balancing selection on the mu-opioid receptor in primates. | the mu opioid receptor is involved in many natural processes including stress response, pleasure, and pain. mutations in the gene also have been associated with opiate and alcohol addictions as well as with responsivity to medication targeting these disorders. two common and mutually exclusive polymorphisms have been identified in humans, a118g (n40d), found commonly in non-african populations, and c17t (v6a), found almost exclusively in african populations. while a118g has been studied extensiv ... | 2017 | 28333316 |
| neuronal degeneration in the dorsal lateral geniculate nucleus following lesions of primary visual cortex: comparison of young adult and geriatric marmoset monkeys. | neuronal loss in the lateral geniculate nucleus (lgn) is a consequence of lesions of the primary visual cortex (v1). despite the importance of this phenomenon in understanding the residual capacities of the primate visual system following v1 damage, few quantitative studies are available, and the effect of age at the time of lesion remains unknown. we compared the volume, neuronal number, and neuronal density in the lgn, 6-21 months after unilateral v1 lesions in marmoset monkeys. stereological ... | 2017 | 28331974 |
| hypoxemia after single-shot anesthesia in common marmosets. | it remains unknown how single-shot anesthesia influences physical parameters, especially respiratory function and blood oxygen level of common marmosets (callithrix jacchus) which came to be used for laboratory research. | 2017 | 28326553 |
| tranexamic acid and supportive measures to treat wasting marmoset syndrome. | wasting marmoset syndrome (wms) has high incidence and mortality rates and is one of the most important problems in captive common marmoset (callithrix jacchus) colonies. despite several reports on wms, little information is available regarding its reliable treatment. we previously reported that marmosets with wms had high serum levels of matrix metalloproteinase 9 (mmp9). mmp9 is thought to be a key enzyme in the pathogenesis of inflammatory bowel disease, the main disease state of wms, and is ... | 2016 | 28304250 |
| how important is the α1 adrenoceptor in primate and rodent proximal urethra? sex differences in the contribution of α1 adrenoceptor to urethral contractility. | urethral smooth muscle (usm) contributes to urinary continence by contracting during the urine storage phase, which is mainly mediated by activation of post-junctional α1-adrenoceptors. males and females show differences in the functioning of the lower urinary tract and the most common urinary tract symptoms (luts). luts in men typically occur in association with bladder outlet obstruction, whereas in women urinary urge-incontinence symptoms are more common. therefore, this study aimed to evalua ... | 2017 | 28298357 |
| retinal, npy- and 5ht- inputs to the aged suprachiasmatic nucleus in common marmosets (callithrix jacchus). | the circadian timing system (cts) anticipates optimal physiological patterns in response to environmental fluctuations, such as light-dark cycle. since age-related disruption of circadian synchronization is linked to several pathological conditions, we characterized alterations of neurochemical constituents and retinal projections to the major pacemaker of cts, the suprachiasmatic nucleus (scn), in adult and aged marmosets. we used intraocular injections of neural tracer cholera toxin b (ctb) to ... | 2017 | 28288865 |
| erratum to: characterization and pathogenesis of aerosolized eastern equine encephalitis in the common marmoset (callithrix jacchus). | 2017 | 28283042 | |
| marmoset flavin-containing monooxygenase 3 in liver is a major benzydamine and sulindac sulfide oxygenase. | common marmosets (callithrix jacchus) are potentially primate models for preclinical drug metabolism studies because the molecular characteristics of cytochrome p450 (p450) enzymes have similarities between this species and humans. however, characterization of non-p450 enzymes have not been clarified in marmosets. here, we report characterization of flavin-containing monooxygenase (fmo) 1-5 identified in marmoset tissues. marmoset fmo forms shared high amino acid sequence identities (93-95%) and ... | 2017 | 28258069 |
| whole-brain metallomic analysis of the common marmoset (callithrix jacchus). | despite the importance of transition metals for normal brain function, relatively little is known about the distribution of these elemental species across the different tissue compartments of the primate brain. in this study, we employed laser ablation-inductively coupled plasma-mass spectrometry on pfa-fixed brain sections obtained from two adult common marmosets. concurrent cytoarchitectonic, myeloarchitectonic, and chemoarchitectonic measurements allowed for identification of the major neocor ... | 2017 | 28246661 |
| comparative pathology of rhesus macaque and common marmoset animal models with middle east respiratory syndrome coronavirus. | middle east respiratory syndrome (mers), which is caused by a newly discovered coronavirus (cov), has recently emerged. it causes severe viral pneumonia and is associated with a high fatality rate. however, the pathogenesis, comparative pathology and inflammatory cell response of rhesus macaques and common marmosets experimentally infected with mers-cov are unknown. we describe the histopathological, immunohistochemical, and ultrastructural findings from rhesus macaque and common marmoset animal ... | 2017 | 28234937 |
| corrigendum: evidence of tau hyperphosphorylation and dystrophic microglia in the common marmoset. | [this corrects the article on p. 315 in vol. 8, pmid: 28066237.]. | 2017 | 28232798 |
| behavioral phenotypes associated with mptp induction of partial lesions in common marmosets (callithrix jacchus). | parkinson's disease is a chronic neurodegenerative disorder with the core motor features of resting tremor, bradykinesia, rigidity, and postural instability. non-motor symptoms also occur, and include cognitive dysfunction, mood disorders, anosmia (loss of smell), and rem sleep disturbances. as the development of medications and other therapies for treatment of non-motor symptoms is ongoing, it is essential to have animal models that aid in understanding the neural changes underlying non-motor p ... | 2017 | 28219749 |
| use of human methylation arrays for epigenome research in the common marmoset (callithrix jacchus). | we examined the usefulness of commercially available dna methylation arrays designed for the human genome (illumina humanmethylation450 and methylationepic) for high-throughput epigenome analysis of the common marmoset, a nonhuman primate suitable for research on neuropsychiatric disorders. from among the probes on the methylation arrays, we selected those available for the common marmoset. dna methylation data were obtained from genomic dna extracted from the frontal cortex and blood samples of ... | 2017 | 28215819 |
| assisted reproductive technologies in the common marmoset: an integral species for developing nonhuman primate models of human diseases†. | 2017 | 28203717 | |
| marmoset cytochrome p450 3a4 ortholog expressed in liver and small-intestine tissues efficiently metabolizes midazolam, alprazolam, nifedipine, and testosterone. | common marmosets (callithrix jacchus), small new world primates, are increasingly attracting attention as potentially useful animal models for drug development. however, characterization of cytochrome p450 (p450) 3a enzymes involved in the metabolism of a wide variety of drugs has not investigated in marmosets. in this study, sequence homology, tissue distribution, and enzymatic properties of marmoset p450 3a4 ortholog, 3a5 ortholog, and 3a90 were investigated. marmoset p450 3a forms exhibited h ... | 2017 | 28196829 |
| anatomical study of the brachial plexus in the common marmoset (callithrix jacchus). | to elucidate the forelimb phylogeny of primates, anatomical analysis of the brachial plexus in platyrrhines is beneficial. in the present study, six brachial plexuses and the surrounding arteries of four common marmosets were dissected. in five specimens, the brachial plexus consisted of five ventral rami from the fifth cervical nerve (c5) to the first thoracic nerve (t1). in one specimen, the ventral ramus of the fourth cervical nerve joined with the brachial plexus. in five specimens, the uppe ... | 2017 | 28187501 |
| characterization and pathogenesis of aerosolized eastern equine encephalitis in the common marmoset (callithrix jacchus). | licensed antiviral therapeutics and vaccines to protect against eastern equine encephalitis virus (eeev) in humans currently do not exist. animal models that faithfully recapitulate the clinical characteristics of human eeev encephalitic disease, including fever, drowsiness, anorexia, and neurological signs such as seizures, are needed to satisfy requirements of the food and drug administration (fda) for clinical product licensing under the animal rule. | 2017 | 28173871 |
| propagation of pathological α-synuclein in marmoset brain. | α-synuclein is a defining, key component of lewy bodies and lewy neurites in parkinson's disease (pd) and dementia with lewy bodies (dlb), as well as glial cytoplasmic inclusions in multiple system atrophy (msa). the distribution and spreading of these pathologies are closely correlated with disease progression. recent studies have revealed that intracerebral injection of synthetic α-synuclein fibrils or pathological α-synuclein prepared from dlb or msa brains into wild-type or transgenic animal ... | 2017 | 28148299 |
| spontaneous mediastinal myeloid sarcoma in a common marmoset (callithrix jacchus) and review of the veterinary literature. | myeloid sarcoma is a rare manifestation of myeloproliferative disorder defined as an extramedullary mass composed of myeloid precursor cells. a 9-month old, female, common marmoset (callithrix jacchus) had increased respiratory effort. | 2017 | 28145579 |
| the effect of mirtazapine on dopaminergic psychosis and dyskinesia in the parkinsonian marmoset. | parkinson's disease (pd) psychosis is encountered in as many as 50% of patients with advanced disease. treatment options for pd psychosis are few. in fact, only clozapine and pimavanserin have shown efficacy in randomised controlled trials. clinicians are often reluctant to prescribe the former, due to the risk of agranulocytosis, while the latter is not widely available yet. because it is already clinically available and exhibits high affinity for serotonin 2a receptors, a target with which bot ... | 2017 | 28130646 |
| long-term-stability of relationship structure in family groups of common marmosets, and its link to proactive prosociality. | cooperatively breeding, group-living common marmosets show differentiated relationships, where more strongly bonded dyads within a group engage more in affiliative interactions than less strongly bonded ones. intriguingly, recent results suggest that strong bonds do not only occur between breeding partners but between individuals from any sex or status, and that strong-bond partners exhibit correlated oxytocin fluctuations (dyadic oxytocin synchrony, ots) over a period of six weeks. to date, it ... | 2017 | 28115225 |
| audience affects decision-making in a marmoset communication network. | an audience can have a profound effect on the dynamics of communicative interactions. as a result, non-human primates often adjust their social decision-making strategies depending on the audience composition at a given time. here we sought to test how the unique vocal behaviour of multiple audience members affected decisions to communicate. to address this issue, we developed a novel experimental paradigm in which common marmosets directly interacted with multiple 'virtual monkeys' (vms), each ... | 2017 | 28100720 |
| harmonic template neurons in primate auditory cortex underlying complex sound processing. | harmonicity is a fundamental element of music, speech, and animal vocalizations. how the auditory system extracts harmonic structures embedded in complex sounds and uses them to form a coherent unitary entity is not fully understood. despite the prevalence of sounds rich in harmonic structures in our everyday hearing environment, it has remained largely unknown what neural mechanisms are used by the primate auditory cortex to extract these biologically important acoustic structures. in this stud ... | 2017 | 28096341 |
| metabolic dysregulation in hepacivirus infection of common marmosets (callithrix jacchus). | chronic hepatitis c has been associated with metabolic syndrome that includes insulin resistance, hepatic steatosis and obesity. these metabolic aberrations are risk factors for disease severity and treatment outcome in infected patients. experimental infection of marmosets with gbv-b serves as a tangible, small animal model for human hcv infection, and while virology and pathology are well described, a full investigation of clinical disease and the metabolic milieu is lacking. in this study six ... | 2017 | 28085952 |
| evidence of tau hyperphosphorylation and dystrophic microglia in the common marmoset. | common marmosets (callithrix jacchus) have recently gained popularity in biomedical research as models of aging research. basically, they confer advantages from other non-human primates due to their shorter lifespan with onset of appearance of aging at 8 years. old marmosets present some markers linked to neurodegeneration in the brain such as amyloid beta (aβ)1-42 and aβ1-40. however, there are no studies exploring other cellular markers associated with neurodegenerative diseases in this non-hu ... | 2016 | 28066237 |
| pain relief in nonhuman primate models of arthritis. | animal models of rheumatoid arthritis are important in the elucidation of etiopathogenic mechanisms of the disease and for the development of promising new therapies. species specificity of new biological compounds and their mode of action preclude safety and efficacy testing in rodent models of disease. nonhuman primates (nhp) can fill this niche and provide the only relevant model. over the last two decades models of collagen-induced arthritis (cia) were developed in the rhesus monkey and the ... | 2017 | 28063060 |
| transcriptional regulation of follicle-stimulating hormone β-subunit in marmoset by an alternate distal promoter. | follicle-stimulating hormone (fsh) is essential for mammalian folliculogenesis and spermatogenesis. common marmoset (callithrix jacchus) is a new world primate which exhibits an unusual fsh profile across the ovarian cycle with a mid-follicular fsh peak that is not observed in catarrhini primates like humans. since transcription of fsh β-subunit gene (fshβ) is a rate-limiting step in the production of mature fsh, this study aimed to investigate the regulation of marmoset fshβ gene expression in ... | 2017 | 28062307 |
| neurometabolic profiles of the substantia nigra and striatum of mptp-intoxicated common marmosets: an in vivo proton mrs study at 9.4 t. | given the strong coupling between the substantia nigra (sn) and striatum (str) in the early stage of parkinson's disease (pd), yet only a few studies reported to date that have simultaneously investigated the neurochemistry of these two brain regions in vivo, we performed longitudinal metabolic profiling in the sn and str of 1-methyl-1,2,3,6-tetrahydropyridine (mptp)-intoxicated common marmoset monkey models of pd (n = 10) by using proton mrs ((1) h-mrs) at 9.4 t. t2 relaxometry was also perform ... | 2017 | 28028868 |
| survey of retinal ganglion cell morphology in marmoset. | in primate retina, the midget, parasol, and small bistratified cell populations form the large majority of ganglion cells. in addition, there is a variety of low-density wide-field ganglion cell types that are less well characterized. here we studied retinal ganglion cells in the common marmoset, callithrix jacchus, using particle-mediated gene transfer. ganglion cells were transfected with an expression plasmid for the postsynaptic density 95-green fluorescent protein. the retinas were processe ... | 2016 | 27997691 |
| dynamic regulation of hypothalamic dmxl2, kiss1, and rfrp expression during postnatal development in non-human primates. | the neurobiological mechanism of puberty onset in primates is currently only partly understood. a recent study reported an important role of dmx-like 2 (dmxl2), a gene encoding rabconnectin-3α vesicular protein, in human subjects with mental retardation and neuroendocrine impairment of reproduction. to further characterize the potential role of dmxl2 in the regulation of reproduction, we analyzed the expression of dmxl2 in hypothalami of newborn, infantile, juvenile, pubertal, and postpubertal f ... | 2016 | 27957681 |
| effects of the 5-ht1a receptor agonists buspirone and 8-oh-dpat on pupil size in common marmosets. | as pupil size is affected by psychotropic drugs in all mammals, it has been used as a well-established clinical indicator for the preclinical and clinical development of novel drugs. it has been reported that activation of the serotonin (5-ht)1a receptor differently affects pupil response in rodents (mydriasis) and humans (miosis). thus, it is important to establish a quantitative system for measuring pupil size using other species, such as nonhuman primates. common marmosets have recently attra ... | 2017 | 27922541 |
| cryobiological parameters of multipotent stromal cells obtained from different sources. | stem cells are important for regenerative medicine mainly due to their multilineage differentiation capacity. however, the cells rapidly loose this capability during culturing. cryopreservation preserves the differentiation potential of the cells, until they are needed. in this study, specific cell properties of multipotent stromal cells (mscs), from the common marmoset monkey callithrix jacchus mscs derived from amnion (am) and bone marrow (bm) were studied in order to predict optimal cooling r ... | 2017 | 27916562 |
| distinct neural activities in premotor cortex during natural vocal behaviors in a new world primate, the common marmoset (callithrix jacchus). | although evidence from human studies has long indicated the crucial role of the frontal cortex in speech production, it has remained uncertain whether the frontal cortex in nonhuman primates plays a similar role in vocal communication. previous studies of prefrontal and premotor cortices of macaque monkeys have found neural signals associated with cue- and reward-conditioned vocal production, but not with self-initiated or spontaneous vocalizations (coudé et al., 2011; hage and nieder, 2013), wh ... | 2016 | 27903726 |
| cloning and expression of a novel catechol-o-methyltransferase in common marmosets. | catechol-o-methyltransferase (comt) catalyzes the o-methylation of endogenous catechol amines and estrogens and exogenous catechol-type of drugs. a parkinson's disease model of common marmoset (callithrix jacchus) has been widely used in preclinical studies to evaluate inhibitory potential of new drug candidates on marmoset comt. despite comt inhibitors could potentiate the pharmacological action of levodopa on parkinson's disease in animal models, marmoset comt cdna has not yet been identified ... | 2017 | 27890888 |
| systematic evaluation of monoclonal antibodies and immunoassays for the detection of interferon-γ and interleukin-2 in old and new world non-human primates. | non-human primates (nhp) provide important animal models for studies on immune responses to infections and vaccines. when assessing cellular immunity in nhp, cytokines are almost exclusively analyzed utilizing cross-reactive anti-human antibodies. the functionality of antibodies has to be empirically established for each assay/application as well as nhp species. a rational approach was employed to identify monoclonal antibodies (mab) cross-reactive with many nhp species. panels of new and establ ... | 2017 | 27889562 |
| differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (callithrix jacchus). | inherited and acquired marrow failure syndromes most commonly lead to defect in myeloid and/or neutrophil differentiation and/or function. besides this, neutropenia induced by cancer-adjusted chemotherapy is a frequent clinical problem. in both cases, cell replacement therapy is a well-established, but due to necessity of donors limited and perilous procedure. therefore, autologous cell replacement from patients' own marrow-derived cells lowers risk and bares new possibilities for therapy. since ... | 2017 | 27888517 |
| contextual effects of noise on vocalization encoding in primary auditory cortex. | robust auditory perception plays a pivotal function for processing behaviorally relevant sounds, particularly with distractions from the environment. the neuronal coding enabling this ability, however, is still not well understood. in this study, we recorded single-unit activity from the primary auditory cortex (a1) of awake marmoset monkeys (callithrix jacchus) while delivering conspecific vocalizations degraded by two different background noises: broadband white noise and vocalization babble. ... | 2017 | 27881720 |
| characterization of two distinct early post-entry blocks to hiv-1 in common marmoset lymphocytes. | in nature, primate lentiviruses infect humans and several old world monkeys and apes. however, to date, lentiviruses infecting new world monkeys have not been described. we studied the susceptibility of common marmoset cells to hiv-1 infection and observed the presence of post-entry blocks to the early phase of hiv-1 infection in peripheral blood lymphocytes (pbls) and a b lymphocytic cell line (b-lcl). the blocks present in these cells are dominant and phenotypically different from each other. ... | 2016 | 27876849 |
| local ecological knowledge about endangered primates in a rural community in paraíba, brazil. | the study of local ecological knowledge (lek) fosters a better understanding of the relationship between humans and the environment. we assessed respondents' ecological knowledge of primates in a rural community located near the atlantic forest remnants in the state of paraíba, brazil. populations of alouatta belzebul (red-handed howler monkeys), sapajus flavius (blonde capuchins), and callithrix jacchus (the common marmoset) inhabit the region. we conducted 200 semi-structured interviews and ap ... | 2016 | 27866209 |
| strong induction of cytochrome p450 1a/3a, but not p450 2b, in cultured hepatocytes from common marmosets and cynomolgus monkeys by typical human p450 inducing agents. | common marmosets (callithrix jacchus) and cynomolgus monkeys (macaca fascicularis) are used as non-human primate models in preclinical studies for drug development. | 2016 | 27842484 |
| centromere repositioning explains fundamental number variability in the new world monkey genus saimiri. | cytogenetics has historically played a key role in research on squirrel monkey (genus saimiri) evolutionary biology. squirrel monkeys have a diploid number of 2n = 44, but vary in fundamental number (fn). apparently, differences in fn have phylogenetic implications and are correlated with geographic regions. a number of hypothetical mechanisms were proposed to explain difference in fn: translocations, heterochromatin, or, most commonly, pericentric inversions. recently, an additional mechanism, ... | 2016 | 27834006 |
| topical diclofenac-loaded liposomes ameliorate laser-induced choroidal neovascularization in mice and non-human primates. | this study aimed to evaluate the effect of liposomes loaded with diclofenac, a potent cyclooxygenase (cox)-1 and cox-2 inhibitor, on laser-induced choroidal neovascularization (cnv) in mice and non-human primates (common marmosets). cnv was induced by laser irradiation on the unilateral or bilateral eye of each mouse or common marmoset, respectively, under anesthesia. the cnv was visualized using fluorescence labeling with intravenous injection of fluoresceinconjugated dextran (molecular weight ... | 2017 | 27823554 |
| brain/minds: a japanese national brain project for marmoset neuroscience. | brain/minds (brain mapping by integrated neurotechnologies for disease studies) is a national brain project started by japan in 2014. with the goal of developing the common marmoset as a model animal for neuroscience, the project aims to build a multiscale marmoset brain map, develop new technologies for experimentalists, create transgenic lines for brain disease modeling, and integrate translational findings from the clinical biomarker landscape. brain/minds will collaborate with global brain p ... | 2016 | 27809998 |
| psychophysical measurement of marmoset acuity and myopia. | the common marmoset has attracted increasing interest as a model for visual neuroscience. a measurement of fundamental importance to ensure the validity of visual studies is spatial acuity. the marmoset has excellent acuity that has been reported at the fovea to be nearly half that of the human (ordy and samorajski []: vision res 8:1205-1225), a value that is consistent with them having similar photoreceptor densities combined with their smaller eye size (troilo et al. []: vision res 33:1301-131 ... | 2017 | 27804251 |
| induction of humoural and cellular immunity by immunisation with hcv particle vaccine in a non-human primate model. | although hcv is a major cause of chronic liver disease worldwide, there is currently no prophylactic vaccine for this virus. thus, the development of an hcv vaccine that can induce both humoural and cellular immunity is urgently needed. to create an effective hcv vaccine, we evaluated neutralising antibody induction and cellular immune responses following the immunisation of a non-human primate model with cell culture-generated hcv (hcvcc). | 2016 | 27797937 |
| de novo methylation in male germ cells of the common marmoset monkey occurs during postnatal development and is maintained in vitro. | the timing of de novo dna methylation in male germ cells during human testicular development is yet unsolved. apart from that, the stability of established imprinting patterns in vitro is controversially discussed. this study aimed at determining the timing of dna de novo methylation and at assessing the stability of the methylation status in vitro. we employed the marmoset monkey (callithrix jacchus) as it is considered the best non-human primate model for human testicular development. we selec ... | 2016 | 27786608 |
| chronic multiscale imaging of neuronal activity in the awake common marmoset. | we report a methodology to chronically record in vivo brain activity in the awake common marmoset. over a month, stable imaging revealed macroscopic sensory maps in the somatosensory cortex and their underlying cellular activity with a high signal-to-noise ratio in the awake but not anesthetized state. this methodology is applicable to other brain regions, and will be useful for studying cortical activity and plasticity in marmosets during learning, development, and in neurological disorders. | 2016 | 27786241 |
| very low doses of mycobacterium tuberculosis yield diverse host outcomes in common marmosets (callithrix jacchus). | identifying and refining small-animal models of tuberculosis that recapitulate aspects of human mycobacterium tuberculosis infection can contribute to advancing our understanding of critical facets of the disease. to study the effects of very low-dose infections with 2 strains of m. tuberculosis on disease progression and survival in common marmosets, animals were challenged with strains erdman and cdc1551 at doses ranging from 1 to 12 cfu. these data revealed that the susceptibility of marmoset ... | 2016 | 27780009 |
| antisera against neisseria gonorrhoeae cross-react with specific brain proteins of the common marmoset monkey and other nonhuman primate species. | prenatal maternal infections with neisseria gonorrhoeae (ng) correlate with an increased lifetime probability for the offspring to develop psychosis. we could previously demonstrate that in human choroid plexus papilloma cells, anti-ng antibodies (α-ng) bind to mitochondrial proteins hsp60 and atpb, and interfere with cellular energy metabolism. to assess the in vivo relevance for this, especially during prenatal neural development, we investigated here interactions of ng-specific antisera (α-ng ... | 2016 | 27765579 |
| investigation of sleep-wake rhythm in non-human primates without restraint during data collection. | to understand sleep mechanisms and develop treatments for sleep disorders, investigations using animal models are essential. the sleep architecture of rodents differs from that of diurnal mammals including humans and non-human primates. sleep studies have been conducted in non-human primates; however, these sleep assessments were performed on animals placed in a restraint chair connected via the umbilical area to the recording apparatus. to avoid restraints, cables, and other stressful apparatus ... | 2017 | 27760892 |
| differences in toxicological and pharmacological responses mediated by polymorphic cytochromes p450 and related drug-metabolizing enzymes. | research over the past 30 years has elucidated the roles of polymorphic human liver cytochrome p450 (p450) enzymes associated with toxicological and/or pharmacological actions. thalidomide exerts its various pharmacological and toxic actions in primates through multiple mechanisms, including nonspecific modification of many protein networks after bioactivation by autoinduced human p450 enzymes. to overcome species differences between rodents, currently, nonhuman primates and/or mouse models with ... | 2017 | 27750412 |
| magnetic resonance imaging of experimental autoimmune encephalomyelitis in the common marmoset. | magnetic resonance imaging (mri) is an invaluable tool for the diagnosis and monitoring of patients with multiple sclerosis (ms) as well as for the study of the disease pathophysiology. because of its strong clinical, radiological and histopathological similarities with the human disease, experimental autoimmune encephalomyelitis (eae) in the common marmoset has been studied more intensively over the past several years. here, we review the current knowledge on mri in the marmoset eae, and we out ... | 2017 | 27743612 |
| the marmoset as a model system for studying voluntary motor control. | the common marmoset has recently gained interest as an animal model for systems and behavioral neuroscience. this is due in part to the advent of transgenic marmosets, which affords the possibility of combining genetic manipulations with physiological recording and behavioral monitoring to study neural systems. in this review, they will argue that the marmoset provides a unique opportunity to study the neural basis of voluntary motor control from an integrative perspective. first, as an intermed ... | 2017 | 27739220 |