Publications

[the hypothesis of infectious etiology for idiopathic nervous system diseases: from the postulates of koch to the criteria of hill].	the evaluation of the hypothesis of an infectious etiology to some neurological diseases comprises four different situations. first, numerous neurological diseases have an obvious infectious etiology (encephilitis, meningoencephilitis). second, some neurological disorders were primarily suspected to be have an infectious etiology, but the causative microorganism was discovered either longtime after the princeps description of the disease (neurologic whipple disease, due to tropheryma whippelii), ...	1999	10598368
tropheryma whippelii in synovial tissue and fluid.		1999	10577317
pcr for tropheryma whippelii.		1999	10543701
polymerase chain reaction analysis for diagnosis of tropheryma whippelii infective endocarditis in two patients with no previous evidence of whipple's disease.		1999	10525255
hypertrophic osteoarthropathy can indicate recurrence of whipple's disease.	we report the case of a patient with whipple's disease (wd) who developed hypertrophic osteoarthropathy (hoa) characterized by digital clubbing, periostosis of the tubular bones, and polysynovitis. the hoa disclosed the recurrence of the patient's wd, since polymerase chain reaction (pcr) analysis clearly demonstrated the presence of tropheryma whippelii in the synovial fluid from the patient's left knee. initiation of appropriate antibiotic therapy resulted in complete healing of all clinical r ...	1999	10513818
tropheryma whippelii dna in saliva of healthy people.	in a random sample of 40 healthy people, 35% showed evidence of tropheryma whippelii dna in their saliva. consistent detection of t. whippelii dna on repeated sampling suggests that this organism can be an oral commensal.	1999	10513716
relapsing whipple's disease presenting with hypopituitarism.	a 44-year-old man with a history of whipple's disease 8 years ago presented with recurrent grand mal seizures and signs of hypopituitarism on physical examination. magnetic resonance imaging of the brain revealed a hypothalamic lesion of 1 cm diameter in the region of the rostral infundibulum. hypopituitarism was confirmed by low levels of serum cortisol, free testosterone and free thyroxine without an elevated tsh. whipple encephalitis with hypothalamic involvement was suggested and verified by ...	1999	10435068
pcr analysis in the pathological diagnosis of whipple's disease: emphasis on extraintestinal involvement or atypical morphological features.	pcr analysis of species-specific bacterial 16s rrna gene of tropheryma whippelii was performed in biopsies from 10 cases of whipple's disease (wd). in seven patients showing the typical clinical picture of wd, pcr was performed on the diagnostic intestinal biopsy. in the remaining three cases (an autopsy case of disseminated wd and two patients showing lymphadenopathy as the initial clinical presentation), pcr was done on lymph node specimens. in one of the lymph node biopsies, an unusual sarcoi ...	1999	10419602
whipple endocarditis without overt gastrointestinal disease: report of four cases.	cardiac manifestations of whipple disease are rarely diagnosed before death.	1999	10419427
pcr-positive tests for tropheryma whippelii in patients without whipple's disease.		1999	10392994
[whipple's disease in a man with weight loss and diarrhea].	in a 45-year-old man with diarrhoea, upper abdominal pain and malabsorption whipple's disease was diagnosed by gastroduodenoscopy with small bowel biopsies. the disease is rare and can present with gastrointestinal problems but also with cardiac or neurological complaints. tropheryma whippelii, the aetiological organism, can be demonstrated by pathological investigation of biopsies and with the polymerase chain reaction (pcr). treatment with trimethoprim-sulfamethoxazole 160-800 mg twice daily i ...	1999	10221112
[whipple's disease].	whipple's disease is characterized by malabsorption, weight loss, diarrhoea and abdominal pain, often preceded by a long period of migrating arthralgias. instead of the intestine the heart, brain, eyes, lungs or blood vessels may be affected. whipple's disease is caused by tropheryma whippelii, a bacillus found inside phagocytes. a specific defect in the immune system of the host appears to play a part. the diagnosis is based on microscopic examination of periodic-acid-schiff(pas)-stained slides ...	1999	10221107
whipple's arthritis: direct detection of tropheryma whippelii in synovial fluid and tissue.	we describe 2 patients presenting with polyarthritis in whom the synovial fluid (1 patient) or synovial tissue (1 patient) was positive for tropheryma whippelii, the whipple's disease-associated bacillus, when examined by polymerase chain reaction (pcr) and dna sequencing. histopathologic findings were consistent with articular whipple's disease in the synovial fluid of 1 patient and the synovial tissue of the other. in both patients, bowel mucosal specimens were negative for whipple's disease f ...	1999	10211899
anonymous survey of blood donors by polymerase chain reaction for tropheryma whippelii.		1999	10209674
diagnosis and follow-up of whipple's disease by amplification of the 16s rrna gene of tropheryma whippelii.	amplification of the 16s rrna gene of tropheryma whippelii was performed in eight patients with whipple's disease and 34 control patients to confirm a diagnosis of whipple's disease and to monitor the course of disease. polymerase chain reaction (pcr) tests were positive before treatment in 13 of 15 tissue samples from whipple's disease patients (gut 8/8; lymph nodes 2/2; bone marrow 1/2; peripheral blood 2/3), in contrast to none of 54 tissue samples from controls. pcr tests converted to negati ...	1999	10192717
[tropheryma whippelii, an emerging intracellular pathogen causing whipple disease].	clinical diagnosis: whipple's disease is a diffuse disease with a wide variety of clinical manifestations. differential diagnoses include chronic enteritis, chronic joint disease, chronic meningoencephalitis and prolonged fever with weight loss, chronic uveitis and endocarditis with negative blood culture. molecular diagnosis: histologically the characteristic lesions contain pas-positive inclusions. pcr of rnar gene 16s in fresh tissue identifies tropheryma whippelii and confirms bacteriologica ...	1999	10093605
detection of tropheryma whippelii dna (whipple's disease) in faeces.	to date the diagnosis of whipple's disease is based mainly on the histopathological analysis of duodenal biopsies since tropheryma whippelii cannot be cultured in vitro. we investigated the possibility to diagnose whipple's disease by detection of bacterial dna in faces. nested polymerase chain reaction with amplification of part of the 16s rrna gene of this bacterium in dna extracted from faeces of a patient with whipple's disease was performed. sequencing of the polymerase chain reaction produ ...	1999	10091107
a rare case of aortic valve endocarditis caused by tropheryma whippelii with left coronary cusp perforation diagnosed by transoesophageal echocardiography and pcr.		1999	9922364
rheumatologic manifestations of gastrointestinal disorders.	there are many different rheumatic symptoms of gastrointestinal (gi) disorders and a whole range of gi symptoms that occur in rheumatologic disorders. spondyloarthropathies (spa) are closely related to the gi tract. bacterial dna has been detected in peripheral but not the sacroiliac joints of patients, including enterobacteria; the significance of this finding is not clear yet because antibiotic therapy seems not to be effective. the synovial lymphocyte proliferation of reactive arthritis (rea) ...	1999	9894633
whipple's disease.	whipple's disease is a chronic, multisystem disease that is caused by tropheryma whippelii infection. more information is now known about this unusual infectious process, which was once considered uniformly fatal. immunologic, diagnostic, and therapeutic advancements are reviewed in this article. hopefully, future advances in the basic and clinical sciences will lead to a more rapid diagnosis, more complete understanding of the effects of infection, improved therapy, and better clinical outcome.	1998	9891703
homogeneity of 16s-23s ribosomal intergenic spacer regions of tropheryma whippelii in swiss patients with whipple's disease.	the current genetic strategies used to identify tropheryma whippelii, the putative agent of whipple's disease, are based on pcr-mediated amplification of a part of its 16s rrna gene (16s rdna). because there is very little intraspecies variation in these molecules, they are not suitable as targets for epidemiologic investigations. however, the intergenic spacer region between the 16s and 23s rdnas is usually much more variable and has repeatedly been used for epidemiologic purposes. we have ther ...	1999	9854081
abdominal lymphomas, convulsive seizure and coma: a case of successfully treated, advanced whipple's disease with cerebral involvement.	whipple's disease is a rare, generalized inflammatory disorder due to the recently described bacterium tropheryma whippelii. we report an unusual, successfully treated case of a 32-year-old woman, who presented with a 25 month history of large abdominal lymphomas, polyserositis and cachexia. the diagnosis of whipple's disease was confirmed by duodenoscopy, lymph node and duodenal histology and polymerase chain reaction analysis of biopsy material and cerebrospinal fluid. a prolonged convulsive s ...	1998	9831415
whipple's syndrome (uveitis, b27-negative spondylarthropathy, meningitis, and lymphadenopathy) associated with arthrobacter sp. infection.	to report an unusual case of whipple's disease, including uveitis, seronegative spondylarthropathy, meningitis, and lymphadenopathy, associated with an arthrobacter sp. infection.	1998	9787360
ocular manifestations of whipple disease: an atypical presentation.	a 62-year-old man developed bilateral granulomatous iridocyclitis after uncomplicated cataract surgery. on ophthalmic examination, we found moderate inflammation in the anterior chamber and vitreous, with granular crystalline deposits on the iris, intraocular lens, and capsular bag. biopsy of the lens capsule and vitreous revealed periodic acid-schiff-positive, diastase-resistant bacilli consistent with tropheryma whippelii. electron microscopy and polymerase chain reaction confirmed the diagnos ...	1998	9747687
pcr analysis of t. whippelii dna in a case of whipple's disease: effect of antibiotics and correlation with histology.	a 58-yr-old man developed severe weight loss, arthralgias, and diarrhea. endoscopic examination of the stomach and duodenum revealed thickened folds of duodenal mucosa. biopsy of the gastric mucosa was negative, whereas duodenal biopsy revealed blunted epithelial villi and pas-positive foamy macrophages within the lamina propria. bacilli typical of those associated with whipple's disease were found by electron microscopy. the diagnosis was confirmed by polymerase chain reaction (pcr) assay, whic ...	1998	9732952
whipple disease presenting as posterior uveitis without prominent gastrointestinal symptoms.	to describe the clinical presentation and course of whipple disease in an adult.	1998	9683160
whipple's disease with aortic regurgitation requiring aortic valve replacement.	cardiac involvement in whipple's disease is well established. however, clinical consequences beside antibiotic therapy have rarely been reported. our observation of a middle-aged man with increasing dyspnea, fatigue, chest pain, and dizziness leading to admission to a cardiology department demonstrates that cardiac symptoms may represent the main symptoms in patients with whipple's disease. the diagnosis was not made prior to upper endoscopy, performed because of diarrhea, and revealed whipple's ...	1998	9646112
diagnosis and treatment of whipple's disease.	whipple's disease is a rare systemic infectious disease. to date, it has neither been possible to culture the bacillus tropheryma whippelii, nor to infect other individuals with the pathogen. today the diagnosis is confirmed by means of polymerase chain reaction (pcr) technology. typically, the material for the pcr analysis comes from the duodenum. the diagnosis can also be established in this way on the basis of other tissue, or the cerebrospinal fluid. treatment should only be carried out with ...	1998	9585865
diagnostic utility of the polymerase chain reaction in 2 cases of suspected whipple disease.	we describe 2 patients with a diagnosis of whipple disease in whom the usual antibiotic therapy failed. a polymerase chain reaction-based test was used to identify the recently described whipple bacillus, tropheryma whippelii. in one case, the diagnosis was confirmed, whereas in the second case, which had been histologically diagnosed as whipple disease of the brain, the process was identified as a monocyte-derived histiocytosis. in conclusion, whipple disease can be distinguished from other dis ...	1998	9554687
whipple's disease without malabsorption: new atypical features.	the diagnosis of whipple's disease in the absence of intestinal involvement is difficult and often overlooked. we describe five patients aged 8-71 years with normal jejunal biopsies and disparate clinical features, previously unrecognized in whipple's; all were investigated at a single institution over a period of 18 months. routine histological examination for periodic acid-schiff (pas) positive macrophages and polymerase chain reaction (pcr) analysis for tropheryma whippelii was performed on t ...	1997	9536341
ultrastructural localization of osteopontin immunoreactivity in phagolysosomes and secretory granules of cells in human intestine.	a post-embedding ultrastructural immunogold method was used to detect osteopontin in human intestinal biopsies with special emphasis on secretory and phagocytic organelles. osteopontin immunoreactivity was localized to phagolysosomes of macrophages, fibroblasts, absorptive epithelial cells of the small intestine and paneth cells. the mucigen secretory granules and golgi structures of mucous epithelial cells of the small intestinal epithelium contained osteopontin, but secretory granules of numer ...	1997	9466147
environmental occurrence of the whipple's disease bacterium (tropheryma whippelii).	whipple's disease is a systemic disorder in which a gram-positive rod-shaped bacterium is constantly present in infected tissues. after numerous unsuccessful attempts to culture this bacterium, it was eventually characterized by 16s rrna gene analysis to be a member of the actinomycetes. the name tropheryma whippelii was proposed. until now, the bacterium has only been found in infected human tissues, but there is no evidence for human-to-human transmission. here we report the detection of dna s ...	1998	9464419
invasion and destruction of mucosal plasma cells by tropheryma whippelii.	whipple's disease is a poorly understood systemic disorder associated with the bacillus, tropheryma whippelii. an early stage of whipple's disease is studied by using electron microscopy (elmi) and immunohistochemistry. the diagnosis was confirmed by polymerase chain reaction-amplification and sequencing of the 16s ribosomal-rna of the bacterium. by using elmi, tropheryma whippelii was found in plasma cells and macrophages in the jejunal mucosa. the immunoglobulin (ig)a-positive plasma cells wer ...	1997	9416701
molecular evidence and clinical significance of herpesvirus coinfection in the central nervous system.	a total of 60 cerebrospinal fluid (csf) specimens from patients manifesting symptoms resembling viral central nervous system (cns) disease were examined for the presence of herpes simplex virus (hsv), human herpesvirus 6 (hhv-6), epstein-barr virus (ebv), cytomegalovirus, varicella-zoster virus, borrelia burgdorferi, and tropheryma whippelii dna by pcr. of 30 specimens which were selected on the basis of hsv dna positivity, 2 were concomitantly positive for hhv-6 dna and 1 was positive for ebv d ...	1997	9350749
molecular diagnosis of bacterial endocarditis by broad-range pcr amplification and direct sequencing.	broad-range pcr amplification of part of the 16s rrna gene followed by single-strand sequencing was applied to samples of 18 resected heart valves from patients with infective endocarditis. the pcr results were compared with those of cultures of valves and with those of previous blood cultures. for two patients there was agreement with the cultures of the valves; for nine patients there was agreement with the previous blood cultures, which were positive, while the cultures of the valves were neg ...	1997	9350723
[whipple's disease: molecular biology--clinical aspects--therapy].	whipple's disease is a rare systemic bacterial disease, affecting mostly middle-aged white men. its clinical presentation is very variable. arthralgias, fever of unknown origin or central nervous system symptoms may precede the more typical gastrointestinal manifestations with weight loss and chronic diarrhea. the diagnosis is based on the histopathologic demonstration of pas-positive macrophages in duodenal or jejunal biopsies. in addition, it has become possible to detect the causative actinob ...	1997	9333910
deactivation of macrophages with interleukin-4 is the key to the isolation of tropheryma whippelii.	whipple's disease is a systemic illness caused by a specific agent. despite recognition of bacteria in lesions, efforts to isolate the causative agent remained futile. a novel strategy was devised to culture whipple bacilli in deactivated mononuclear phagocytes. infected tissue was inoculated into human phagocytes deactivated with interleukin (il)-4, il-10, and dexamethasone. within 8-10 days, diastase-resistant periodic acid-schiff-positive inclusions appeared, corresponding to intact and degen ...	1997	9291314
polymerase chain reaction-based detection of tropheryma whippelii in central nervous system whipple's disease.	whipple's disease of the central nervous system (cns) may be associated with normal intestinal histology as a result of minimal or patchy involvement. the diagnosis is difficult and is frequently made post mortem. we studied 6 patients with clinically suspected cns whipple's disease; 2 had oculomasticatury myorhythmia (omm) fitting criteria for a diagnosis of definite cns whipple's disease. one of the 2 had duodenal histology highly suggestive of whipple's disease the other 5 patients had normal ...	1997	9225695
myocarditis in whipple's disease: an unsuspected cause of symptoms and sudden death.	whipple's disease (wd) is an uncommonly diagnosed infection caused by the recently characterized bacillus, tropheryma whippelii. the association of wd with pericarditis and endocarditis is widely recognized, although less attention has been paid to the myocardium as a site of disease. although the disease was uniformly fatal before antibiotic therapy, current treatment usually results in cure. we report two patients whose deaths were directly related to cardiac involvement by wd and whose underl ...	1997	9195567
cerebral relapse of sarcoidlike whipple's disease.	whipple's disease, an infection with the recently identified intracellular bacillus tropheryma whippelii, is a systemic disorder that can be life threatening when untreated. in a few patients, the signs and symptoms of the disease are similar to those of sarcoidosis, and this illness is referred to as sarcoidlike whipple's disease. this variant must be recognized because patients with sarcoidlike whipple's disease must be treated with antibiotics instead of corticosteroids, which would be indica ...	1997	9195094
whipple disease. clinical review of 52 cases. the snfmi research group on whipple disease. société nationale française de médecine interne.	whipple disease is a rare, multiorgan disease with prominent intestinal manifestations. we report a retrospective clinical study of 52 patients recruited in various parts of france from 1967 to 1994. seventy-three percent of the patients were male. clinical manifestations preceding the diagnosis were articular for 35 patients (67%), digestive for 8 patients (15%), general for 7 patients (14%), and neurologic for 2 patients (4%). at a later stage of the disease, 44 patients (85%) presented diarrh ...	1997	9193452
coinfection with tropheryma whippelii and a whipple's disease-associated bacterial organism detected in a patient with central nervous system whipple's disease.		1997	9163508
whipple's disease: comparison of histology with diagnosis based on polymerase chain reaction in four consecutive cases.	polymerase chain reaction (pcr) based detection of species specific sequences of the 16s rrna gene of tropheryma whippelii is a recently described method for diagnosis of whipple's disease.	1997	9135536
strategy for detection and identification of bacteria based on 16s rrna genes in suspected cases of whipple's disease.	the 16s ribosomal rna (rrna) gene of the phylogenetic subdivision containing gram-positive bacteria with a high g + c content was detected specifically in clinical specimens from patients suspected of having whipple's disease. the primary structure of 16s rdna amplified from clinical samples was determined by cloning and sequencing. two sorts of sequences were identified: one corresponded exactly to the rrna sequence of tropheryma whippelii (genbank accession no. m87484) while the other was rela ...	1997	9128199
the syndrome of inappropriate antidiuretic hormone secretion in a patient with whipple's disease.	we report the case of a patient with central nervous system whipple's disease who developed the syndrome of inappropriate antidiuretic hormone secretion (siadh). the patient did not exhibit any gastrointestinal symptoms and initially was diagnosed based on neurologic findings and a duodenal biopsy that was positive for tropheryma whippelii by the polymerase chain reaction. radiologic involvement of the hypothalamus suggested whipple's disease as the likely etiology of the syndrome of inappropria ...	1997	9099157
diagnosis and monitoring of whipple disease by polymerase chain reaction.	whipple disease is a chronic, multisystem disorder associated with infection with tropheryma whippelii, an organism that has not yet been grown on artificial media. in some cases, the diagnosis of whipple disease is uncertain if it is based on histology alone. although antibiotic regimens of various durations have been used, the disease recurs in about one third of cases. no test for cure is available.	1997	9092317
diagnostic application of a polymerase chain reaction assay for the whipple's disease bacterium to intestinal biopsies.	the uncultured whipple's disease bacterium (tropheryma whippelii) was characterized in 1991-1992 by polymerase chain reaction (pcr) and sequencing of the bacterial 16s ribosomal rna gene. the aim of this study was to develop a pcr assay for diagnostic purposes.	1996	8964398
spondylodiscitis caused by tropheryma whippelii.	we describe the first case of spondylodiscitis caused by tropheryma whippelii in which this so far unculturable organism was shown to be present at the site of infection in a patient without significant gastrointestinal symptoms. the methods used included broad-range pcr amplification with universal primers complementary to constant sequences of the gene coding for 16s rrna, direct sequencing of the amplified fragment, and comparison of the sequence determined with those deposited in sequence da ...	1996	8927953
whipple's disease.	whipple's disease (wd) is a rare systemic disease caused by infection with the recently identified actinomycetes, tropheryma whippelii. the disorder affects mostly middle-aged men, and the major clinical features are weight loss, arthropathy, and diarrhea; other symptoms, caused by systemic infection, are not infrequent. the diagnosis is usually established by duodenal biopsy, which shows the pathognomonic periodic acid schiff-positive infiltrates in the lamina propria. in addition, rt-polymeras ...	1996	8903578
prosthetic joint infection caused by tropheryma whippelii (whipple's bacillus).		1996	8852984
[2 cases of whipple disease with different outcomes].	whipple's disease is a rare infectious disease with systemic manifestation on different organs. in 1992 the typical rod-shaped bacillus was identified as a gram-negative actinomycete with distinctive morphologic characteristics and named as tropheryma whippelii. the diagnosis is established by demonstrating the presence of pas-positive macrophages in the mucosa, with large cytoplasmatic granules. we present two cases of whipple's disease with different outcomes. both were treated with the same a ...	1996	8701260
images in clinical medicine. tropheryma whippelii.		1996	8637538
enteropathic arthritis, uveitis, whipple's disease, and miscellaneous spondyloarthropathies.	enteropathic arthritides, uveitis, and whipple's disease all belong to the category of spondyloarthropathies. the exact mechanism of relationships among joint, tendon, and axial involvement in the spondyloarthropathies, and gut and eye involvement, is unsolved. different hypotheses have been proposed to explain the role of enterogenic bacteria in interfering with the hla system and causing inflammatory reactions in these organs. the microorganism responsible for whipple's disease (tropheryma whi ...	1993	7689329
[whipple's disease associated with opportunistic infections].	a 36-year-old man, with a history of recurrent respiratory infection, dermatomycosis, arthralgia and abnormal stools for 12 years, developed a febrile illness (up to 40 degrees c). a serratia marcescens septicaemia responded to antibiotics. four months later cervical and abdominal lymph-adenopathies were noticed. cervical lymph node biopsy revealed lymphadenitis with epithelioid cell nests. duodenoscopy with biopsy demonstrated whipple's disease associated with lambliasis. electron-microscopy sh ...	1993	7685263
whipple's disease with tubular aggregates in asymptomatic muscle.	a patient with whipple's disease aged 34 years is presented. at muscle biopsy, the patient presented with tubular aggregates of the quadriceps muscle. the patient did not exhibit any clinical and electromyographical indications of muscular involvement nor direct or indirect histological indications of muscular infiltration with whipple's bacillus. the possible etiopathogenetic factors creating these aggregates are discussed.	1993	7682899
tropheryma whippelii in peripheral blood mononuclear cells and cells of pleural effusion.		1993	7680741
whipple's disease.	whipple's disease is a chronic systemic infectious disease caused by tropheryma whippelii that typically involves the small intestine and causes malabsorption. extraintestinal manifestations such as arthritis and fever are common and often exist prior to the onset of gastrointestinal symptoms. involvement of the central nervous system can occur and lead to permanent sequelae. weight loss, hyperpigmentation, and lymphadenopathy are frequent findings. the definitive diagnosis is made by biopsy of ...	1995	7586631
detection of tropheryma whippelii dna in a patient with aids.	a case of an aids patient infected with the whipple's disease bacterium, tropheryma whippelii, is reported. a dna fragment with sequence specificity for the 16s rrna gene of the bacterium was detected by pcr in a duodenal biopsy specimen from a 55-year-old male patient with aids and diarrhea. the biopsy specimen contained periodic acid-schiff stain-positive macrophages which did not, however, resemble the sickleform-particle-containing cells characteristic of whipple's disease. this observation ...	1995	7542271
tropheryma whippelii endocarditis confirmed by polymerase chain reaction.	this report concerns a patient with cardiac manifestation of whipple's disease. for the first time, the gene that encodes the 16s rrna of tropheryma whippelii was identified in a native aortic valve by means of a polymerase chain reaction technique. dna amplification gives evidence of tropheryma whippelii as a causative organism in infective endocarditis.	1995	7540550
[an elderly patient with arthralgia, fever, weakness and weight loss. diagnosis of whipple disease by pcr detection of tropheryma whippelii].		1995	7536701
[whipple disease: a single or multiple origin?].	after having been considered as an essentially digestive disease, whipple's disease has appeared more and more to be a multivisceral disease with two main characteristics: on one hand whipple's disease yields a diffuse infiltration of tissues by abnormal macrophages without any other inflammatory reaction; on the other hand, aspects of microbial invasion by intra or extracellular unique rod-shaped gram+bacteria are found. this unusual pathological complex has alternatively been considered as sug ...	1995	7534930
brief report: uveitis caused by tropheryma whippelii (whipple's bacillus)		1995	7529892
[detection of tropheryma whippelii using the polymerase chain reaction before and after therapy of whipple's disease].		1994	7527318
disseminated mycobacterium avium-intracellulare infection in acquired immunodeficiency syndrome mimicking whipple's disease.	we report a patient with acquired immunodeficiency syndrome whose clinical presentation and histologic features resembled whipple's disease. the unique feature of this case was the absence of whipple's bacillus and the presence of mycobacterium avium-intracellulare within macrophages infiltrating the small intestinal lamina propria.	1983	6194041
mast cells in whipple's disease.	abundant degranulating mast cells were observed during an ultrastructural study of jejunal biopsy from an untreated patient with whipple's disease. some of these cells were observed in intimate contact with macrophages containing bacteria in various stages of disintegration. thereafter bacilli were often seen within the cytoplasm of mast cells, enclosed within vacuoles. these findings are suggestive of a cooperation between mast cell and macrophage in the defence of the organism against whipple' ...	1982	6184484
whipple's bacillus.		1982	6176410
electron microscopic detection of whipple's bacillus in sarcoidlike periodic acid-schiff-negative granulomas.	we describe a patient with whipple's disease without apparent intestinal involvement at initial presentation. electron microscopy demonstrated the typical bacilli in pas-negative lymph node and muscle biopsy specimens.	1989	2467786
whipple's disease.	whipple's disease is a systemic bacterial infection that once was uniformly fatal and now is treatable with several different antibiotics in most cases. the exact nature of the whipple's bacillus is unknown, since the organism cannot consistently be cultured. there is also controversy concerning the role of immunologic dysfunction in patients with whipple's disease. in addition to the small intestine, whipple's disease can involve the remainder of the gastrointestinal tract, as well as the lymph ...	1986	2417481
phylogeny of the whipple's-disease-associated bacterium.	efforts to culture and identify the intracellular bacteria associated with whipple's disease have been unsuccessful. nucleotide sequencing and amplification by the polymerase chain reaction was done on the bacterial 16 s ribosomal dna present in a small-bowel biopsy specimen taken from a patient with whipple's disease. a search by computer for similar rrna sequences filed in databases showed the whipple's-associated organism to be most similar to bacteria of the rhodococcus, streptomyces, and ar ...	1991	1714530
identification of the uncultured bacillus of whipple's disease.	whipple's disease is a systemic disorder known for 85 years to be associated with an uncultured, and therefore unidentified, bacillus.	1992	1377787