Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| multiplex antibody detection for noninvasive genus-level diagnosis of prosthetic joint infection. | we developed and evaluated a multiplex antibody detection-based immunoassay for the diagnosis of prosthetic joint infections (pjis). sixteen protein antigens from three staphylococcusspecies (staphylococcus aureus,staphylococcus epidermidis, and staphylococcus lugdunensis) (8 antigens),streptococcus agalactiae(4 antigens), and propionibacterium acnes(4 antigens) were selected by comparative immune proteomics using serum samples from pji cases versus controls. a bead-based multiplex immunoassay t ... | 2016 | 26865683 |
| genome stability of propionibacterium acnes: a comprehensive study of indels and homopolymeric tracts. | we present a species-wide comparative analysis of 90 genomes of propionibacterium acnes that represent the known diversity of the species. our results are augmented by six high-quality genomes and a manual investigation of all gene-sized indels found in the strains. overall, the order of genes is conserved throughout the species. a public sybil database for easy comparative analysis of the 90 genomes was established. the analysis of indels revealed a total of 66 loci of non-core genes that corre ... | 2016 | 26857276 |
| isolation of propionibacterium acnes among the microbiota of primary endodontic infections with and without intraoral communication. | the presence of opportunistic pathogens such as propionibacterium acnes (p. acnes) may contribute to the endodontic pathology. the presence of p. acnes may be influenced by different endodontic conditions. the aims of the study were firstly, to identify p. acnes within the whole cultivable microbiota of primary endodontic infections, to investigate which p. acnes phylotypes predominate in such infections and secondly to determine if the presence of an "open" communication (e.g. a sinus) can be a ... | 2016 | 26856712 |
| systematic review of antibiotic resistance in acne: an increasing topical and oral threat. | topical and oral antibiotics are routinely used to treat acne. however, antibiotic resistance is increasing, with many countries reporting that more than 50% of propionibacterium acnes strains are resistant to topical macrolides, making them less effective. we reviewed the current scientific literature to enable proposal of recommendations for antibiotic use in acne treatment. references were identified through pubmed searches for articles published from january, 1954, to march 7, 2015, using fo ... | 2016 | 26852728 |
| effects of magnesium ascorbyl phosphate on the expression of inflammatory biomarkers after treatment of cultured sebocytes with propionibacterium acnes or ultraviolet b radiation. | 2016 | 26848238 | |
| wide-spectrum activity of a silver-impregnated fabric. | fabrics, such as clothing, drapes, pillowcases, and bedsheets are potential sources of pathogenic bacteria and viruses. we found fabrics (ie, professional clothing, pillowcases, and lab coats) treated with a silver-impregnated material to be effective in significantly reducing a wide spectrum of ordinary and drug-resistant microorganisms, including salmonella, methicillin-resistant staphylococcus aureus, propionibacterium acnes, trichphyton mentagrophytes, and norovirus. fabrics impregnated with ... | 2016 | 26827093 |
| overview: the role of propionibacterium acnes in nonpyogenic intervertebral discs. | propionibacterium acnes (p. acnes), an important opportunistic anaerobic gram-positive bacterium, causes bone and joint infections, discitis and spondylodiscitis. accumulated evidence suggested that this microbe can colonise inside intervertebral discs without causing symptoms of discitis. epidemiological investigation shows that the prevalence ranges from 13 % to 44 %. furthermore, colonisation by p. acnes inside nonpyogenic intervertebral discs is thought to be one pathogen causing sciatica, m ... | 2016 | 26820744 |
| propionibacterium acnes: disease-causing agent or common contaminant? detection in diverse patient samples by next-generation sequencing. | propionibacterium acnesis the most abundant bacterium on human skin, particularly in sebaceous areas.p. acnesis suggested to be an opportunistic pathogen involved in the development of diverse medical conditions but is also a proven contaminant of human clinical samples and surgical wounds. its significance as a pathogen is consequently a matter of debate. in the present study, we investigated the presence ofp. acnesdna in 250 next-generation sequencing data sets generated from 180 samples of 20 ... | 2016 | 26818667 |
| prospective study using anterior approach did not show association between modic 1 changes and low grade infection in lumbar spine. | the modern literature is producing a rapidly growing number of articles which highlight the relationship between infection and lumbar disc degeneration. however, the means by which samples are collected is questionable. posterior approach surgery is not free from skin contamination. the possibility of intraoperative contamination of disc biopsies cannot be excluded. | 2016 | 26818032 |
| in vitro antimicrobial activity of benzoyl peroxide against propionibacterium acnes assessed by a novel susceptibility testing method. | benzoyl peroxide (bpo), a therapeutic agent for acne vulgaris, was assessed for in vitro antimicrobial activity against propionibacterium acnes using a novel broth microdilution testing that improved bpo solubility. we searched for a suitable culture medium to measure the minimum inhibitory concentration (mic) of bpo against p. acnes and finally found the gifu anaerobic medium (gam) broth supplemented with 0.1(v/v)% glycerol and 2(v/v)% tween 80, in which bpo dissolved up to 1250 μg/ml and p. ac ... | 2016 | 26806150 |
| follicular fluorescence quantity to characterize acne severity: a validation study. | porphyrins are native fluorophores in the follicle openings, visible under ultraviolet-a light. acne severity might be associated with increased propionibacterium acnes colonization and porphyrin production. aim of this study was to investigate whether the parameter fluorescence quantity can be used to measure acne severity. | 2016 | 26804729 |
| antimicrobial activities of ethanol and butanol fractions of white rose petal extract. | white rose (rosa hybrida) petals were extracted with ethanol (etoh) or butanol (buoh), and tested for their antimicrobial activities against two species of gram-positive bacteria, six species of gram-negative bacteria, and two species of fungi. on in vitro antimicrobial assays, helicobacter pylori and propionibacterium acnes were highly susceptible to white rose petal extract (wrpe)-etoh and wrpe-buoh, leading to minimal inhibitory concentrations of 100 and 10 μg/ml for h. pylori and 400 and 40 ... | 2016 | 26802535 |
| differentiating occult propionibacterium acnes infection from aseptic "biologic" interference screw hydrolysis after anterior cruciate ligament reconstruction: introducing a novel culture protocol for detecting low-virulence organisms. | 2015 | 26779549 | |
| staphylococcus aureus carriage rates and antibiotic resistance patterns in patients with acne vulgaris. | overuse of antibiotics has led to the development of antibiotic-resistant strains of staphylococcus aureus, which are occurring more frequently within the community. | 2016 | 26777099 |
| propionibacterium acnes in shoulder surgery: is loss of hair protective for infection? | propionibacterium acnes (p acnes) has been linked to chronic infections in shoulder surgery. it was recently observed during first-time shoulder surgery in healthy patients at a rate between 36% and 56%. male gender and the anterolateral approach were reported risk factors. because the skin biology greatly differs, we aimed to correlate skin complaints with p acnes-positive intraoperative cultures from different tissue layer samples in patients undergoing shoulder surgery for the first time. | 2016 | 26763856 |
| rapid diagnosis of propionibacterium acnes infection in patient with hyperpyrexia after hematopoietic stem cell transplantation by next-generation sequencing: a case report. | the rapid determination of pathogenic agent is very important to clinician for guiding their clinical medication. however, current diagnostic methods are of limitation in many aspects, such as detecting range, time-consuming, specificity and sensitivity. in this report, we apply our new-developing pathogen detection method to clarify that propionibacterium acnes is the causative agent of a two-year-old boy with juvenile myelomonocytic leukemia presenting clinical symptoms including serious rash ... | 2016 | 26743541 |
| staphylococcal lta-induced mir-143 inhibits propionibacterium acnes-mediated inflammatory response in skin. | staphylococcus epidermidis (s. epidermidis) plays a critical role in modulating cutaneous inflammatory responses in skin. although s. epidermidis has been shown to co-colonize with propionibacterium acnes (p. acnes) in acne lesions, it is unclear whether s. epidermidis is involved in the regulation of p. acnes-induced inflammatory responses. in this study, we demonstrated that s. epidermidis inhibited p. acnes-induced inflammation in skin. p. acnes induced the expression of interleukin-6 and tum ... | 2016 | 26739093 |
| [bacterial resistance in acne? a meta-analysis of the controversy]. | acne is one of the dermatological pathologies with the highest incidence around the world. it is a multifactorial disease and its treatment can be complex. propionibacterium acnes play a key role in the inflammation of this dermatosis. topical antibiotics, including mainly erythromycin and clindamycin, have been used, but there is controversy over their use due to the widely documented bacterial resistance. for this reason a meta-analysis of the publications over the past 10 years is presented i ... | 2016 | 26738649 |
| exploring valrubicin's effect on propionibacterium acnes-induced skin inflammation in vitro and in vivo. | acne is a common skin disease involving colonization with propionibacterium acnes (p. acnes), hyperproliferation of the follicular epithelium and inflammatory events. valrubicin is a second-generation anthracycline, non-toxic upon contact, and available in a topical formulation. valrubicin's predecessor doxorubicin possesses antibacterial effects and previously we demonstrated that valrubicin inhibits keratinocyte proliferation and skin inflammation suggesting beneficial topical treatment of acn ... | 2015 | 26734122 |
| compressive spinal epidural mass caused by propionibacterium acnes. | propionibacterium acnes is a gram-positive and facultative anaerobe bacillus that is found within sebaceous follicles of the human skin and recognized as a cause of infections after spinal surgery. to our knowledge, there has been no previously reported case of symptomatic compressive chronic inflammatory epidural mass caused by p. acnes in a patient with no prior spinal procedures. | 2016 | 26721733 |
| flavones isolated from scutellariae radix suppress propionibacterium acnes-induced cytokine production in vitro and in vivo. | scutellariae radix, the root of scutellaria baicalensis, has long been applied in traditional formulations and modern herbal medications. propionibacterium acnes (p. acnes) in follicles can trigger inflammation and lead to the symptom of inflammatory acnes vulgaris. this study was aimed at evaluating the effect of scutellariae radix extract and purified components isolated from it on inflammation induced by p. acnes in vitro and in vivo. the results showed the ethyl acetate (ea) soluble fraction ... | 2015 | 26712724 |
| microorganisms inhabiting follicular contents of facial acne are not only propionibacterium but also malassezia spp. | to clarify the relationship between major cutaneous microorganisms (propionibacterium, staphylococcus and malassezia spp.) and acne vulgaris (acne), we examined the microbiota quantitatively in the follicular contents of inflammatory acne and on the facial skin of patients with acne. fifteen japanese untreated acne outpatients were studied. the follicular contents from inflammatory acne lesions of the face were collected using a comedo extractor. the skin surface samples were obtained by the swa ... | 2016 | 26705192 |
| propionibacterium acnes in primary shoulder arthroplasty: rates of colonization, patient risk factors, and efficacy of perioperative prophylaxis. | recent literature has shown that propionibacterium acnes can be cultured from superficial and deep layers of the shoulder. our aims were to assess the rate of p. acnes colonization in patients undergoing primary shoulder arthroplasty, to identify patient-related risk factors, and to evaluate the efficacy of our perioperative antisepsis protocol. | 2016 | 26704361 |
| deep neck infection and descending mediastinitis as a complication of propionibacterium acnes odontogenic infection. | propionibacterium acnes is an anaerobic, gram-positive bacterium which causes numerous types of infections. isolated propionibacterium acnes deep neck infections are very rare. we present an interesting case of deep neck infection complicated by descending mediastinitis of isolated propionibacterium acnes infection. | 2015 | 26693363 |
| first case of propionibacterium acnes urinary tract infection in a dog. | propionibacterium acnes has been rarely isolated as a commensal from dogs, but there is little evidence of pathogenicity. urinary tract infections are common in dogs and are typically caused by various commensal bacteria. here we present the first case report of a urinary tract infection caused by p. acnes. | 2015 | 26690238 |
| propionibacterium acnes as a cause of lung abscess in a cardiac transplant recipient. | a 29-year-old man was admitted with fevers, cough, left-sided chest pain and lethargy for 1 week. he had a cardiac transplant 10 years prior and was on immunosuppressive drugs. he was found to have a pulmonary lesion and went on to develop a lung abscess. propionibacterium acnes was identified on matrix-assisted laser desorption ionisation mass spectrometry-time of flight and 16s rrna gene sequencing after drainage. he was curatively treated with co-trimoxazole and co-amoxiclav. he divulged a lo ... | 2015 | 26677153 |
| association between lumbar disc degeneration and propionibacterium acnes infection: clinical research and preliminary exploration of animal experiment. | clinical research and animal experiment. | 2016 | 26656049 |
| microbial colonization of normal skin: direct visualization of 194 skin biopsies. | recent genetic studies have suggested the presence of numerous microbial species on and in the skin. we characterised microbial colonization of a large collection of skin biopsies from 194 healthy subjects by fluorescence assay. forty per cent of all biopsies did not show any evidence for microbial colonization. propionibacterium acnes was the sole predominant bacterial species in both sebaceous and non-sebaceous areas. non- p. acnes species were present in approximately 30% of all colonized sam ... | 2016 | 26655456 |
| endotoxin-neutralizing activity and mechanism of action of a cationic α-helical antimicrobial octadecapeptide derived from α-amylase of rice. | we have previously reported that amyi-1-18, an octadecapeptide derived from α-amylase (amyi-1) of rice, is a novel cationic α-helical peptide that exhibited antimicrobial activity against human pathogens, including porphyromonas gingivalis, pseudomonas aeruginosa, propionibacterium acnes, streptococcus mutans, and candida albicans. in this study, to further investigate the potential functions of amyi-1-18, we examined its inhibitory ability against the endotoxic activities of lipopolysaccharides ... | 2016 | 26643956 |
| n-substituted n'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)guanidines--antibacterial, cytotoxic activities and some structure-activity relationships. | a series of n-substituted n'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)guanidine derivatives bearing sulfonamide moiety have been screened in vitro for antibacterial activity against isolates from patients with infections of oral cavity, respiratory tract and intestinal tract. the majority of compounds exhibited good antibacterial potency. 1-[4-chloro-5-methyl-2-(4-trifluoromethylbenzylthio)benzenesulfonyl]-3-(3-sulfamoylphenyl)guanidine (13) showed very strong activity, with mic ≤ 6.2 μg/ml ... | 2015 | 26638540 |
| infection prevention in shoulder surgery. | the microbiome of the shoulder demonstrates distinctive differences to other orthopaedic surgical sites. recent studies have demonstrated that the most common organisms found in deep shoulder infections are coagulase-negative staph lococcal species and propionibacterium acnes . many studies support diligent hand washing, decreasing operative time, routine glove changing, minimizing operating room traffic, and covering instruments as means for decreasing the risk of deep infection. on the other h ... | 2015 | 26631211 |
| propionibacterium acnes infection after shoulder surgery. | propionibacterium acnes has been implicated as a cause of infection following shoulder surgery, may occur up to 2 years after the index operation and has been shown to be responsible for up to 56% of shoulder infections after orthopedic implant. male patients within the population undergoing shoulder surgery are particularly at risk, especially if their shoulder surgery involved prosthesis or was posttraumatic. p. acnes infection can be difficult to diagnose clinically and laboratory techniques ... | 2017 | 26622132 |
| a study on the characterization of propionibacterium acnes isolated from ocular clinical specimens. | there are only a few reports available on characterization of propionibacterium acnes isolated from various ocular clinical specimens. we undertook this study to evaluate the role of p. acnes in ocular infections and biofilm production, and also do the phylogenetic analysis of the bacilli. | 2015 | 26609036 |
| investigation of antibacterial activity of aspidin bb against propionibacterium acnes. | in the present study, antibacterial activity of four kinds of phloroglucinol derivatives extracted from dryopteris fragrans (l.) schott against s. aureus, s. epidermidis and p. acnes has been tested. aspidin bb exerted the strongest antibacterial activity with minimal inhibition concentration (mic) values ranging from 7.81 to 15.63 μg/ml. the time-kill assay indicated that aspidin bb could kill p. acnes completely at 2 mic (mbc) within 4 h. by using afm, we demonstrated extensive cell surface al ... | 2016 | 26596576 |
| effect of surgical delay on bacterial colonization in proximal humeral fractures. | postoperative infection is a severe complication after proximal humeral fracture surgical treatment. the aim of this study was to determine if the surgical delay could modify the number and type of bacteria on the surgical site. a two stages study was set up. in the first stage the effect of delay was simulated in 20 patients affected by proximal humeral fracture treated conservatively. in a second stage, the effect of delay was measured in 20 patients that underwent surgery. in stage 1, three s ... | 2016 | 26580139 |
| draft genome sequences of two propionibacterium acnes strains isolated from progressive macular hypomelanosis lesions of human skin. | propionibacterium acnes is a gram-positive bacterium that is prevalent on human skin. it has been associated with skin disorders such as acne vulgaris and progressive macular hypomelanosis (pmh). here, we report draft genome sequences of two type iii p. acnes strains, pmh5 and pmh7, isolated from pmh skin lesions. | 2015 | 26543110 |
| [low grade endophthalmitis caused by p. acnes : case report]. | low grade endophthalmitis is usually a chronic indolent inflammation that may be misdiagnosed as noninfectious uveitis. therefore, this form of endophthalmitis is often unsuccessfully treated with corticosteroids. we describe the case of a patient with low grade endophthalmitis caused by propionibacterium acnes after cataract surgery. this case report presents the difficulties in establishing the diagnosis of this form of endophthalmitis as well as the benefits of a combined operative therapy wi ... | 2016 | 26531293 |
| [propionibacterium acnes induces the formation of granulomas via promoting th1 and th17 cell differentiation]. | to investigate the immunostimulatory role of propionibacterium acnes (p. acnes) in the differentiation of dendritic cell maturation and t helper (th) subsets, and further explore the potential mechanism of its granuloma-inducing effect. | 2015 | 26522349 |
| multicenter cross-sectional observational study of antibiotic resistance and the genotypes of propionibacterium acnes isolated from chinese patients with acne vulgaris. | antibiotics are widely applied in management of acne vulgaris, which raises the issue of antibiotic resistance. due to improper application and supervision of antibiotics, antibiotic resistance has become a serious problem in china. so, the efficacy of antimicrobial therapy in acne is unclear without an objective monitor of antibiotic resistance of propionibacterium acnes. this cross-sectional, multicenter observational study is aimed at understanding the status of antibiotic resistance in p. ac ... | 2016 | 26508505 |
| two cases of non-prosthetic bone and joint infection due to propionibacterium acnes. | 2016 | 26507785 | |
| suppression of propionibacterium acnes-induced dermatitis by a traditional japanese medicine, jumihaidokuto, modifying macrophage functions. | purpose. macrophages serve as sweepers of microbes and inflammation-derived wastes and regulators of inflammation. some traditional japanese medicines are reported to have adjuvant effects by modifying macrophages. our aim was to characterize the actions of jumihaidokuto (jht) for treatment of skin inflammations including acne vulgaris, in which propionibacterium acnes has pathogenic roles. methods. dermatitis was induced in rat ears by intradermal injection of p. acnes. jht or prednisolone (pdn ... | 2015 | 26495013 |
| comparison of riboflavin and toluidine blue o as photosensitizers for photoactivated disinfection on endodontic and periodontal pathogens in vitro. | photoactivated disinfection has a strong local antimicrobial effect. in the field of dentistry it is an emerging adjunct to mechanical debridement during endodontic and periodontal treatment. in the present study, we investigate the effect of photoactivated disinfection using riboflavin as a photosensitizer and blue led light for activation, and compare it to photoactivated disinfection with the widely used combination of toluidine blue o and red light. riboflavin is highly biocompatible and can ... | 2015 | 26469348 |
| frequent isolation of propionibacterium acnes from the shoulder dermis despite skin preparation and prophylactic antibiotics. | in vitro, propionibacterium acnes (p acnes) is highly susceptible to commonly used antibiotics and antiseptics, yet in vivo, it still causes postsurgical infections of the shoulder. we hypothesized that the local environment within the pilosebaceous glands protects p acnes and that incision of the skin transects these glands, exposing viable p acnes to the wound. | 2016 | 26456428 |
| plasma pharmacokinetics of polyphenols in a traditional japanese medicine, jumihaidokuto, which suppresses propionibacterium acnes-induced dermatitis in rats. | most orally administered polyphenols are metabolized, with very little absorbed as aglycones and/or unchanged forms. metabolic and pharmacokinetic studies are therefore necessary to understand the pharmacological mechanisms of polyphenols. jumihaidokuto (jht), a traditional japanese medicine, has been used for treatment of skin diseases including inflammatory acne. because jht contains various types of bioactive polyphenols, our aim was to clarify the metabolism and pharmacokinetics of the polyp ... | 2015 | 26437394 |
| chemical composition of the essential oil from croton oblongifolius and its antibacterial activity against propionibacterium acnes. | the essential oil of c. oblongifolius roxb. stem bark was obtained by hydrodistillation. chemical analysis by gc-ms identified 29 compounds. terpinen-4-ol (17.8%) was a major component, together with α-guaiene (7.9%), e-caryophyllene (7.0%), myrcene (6.7%), (+)-cyclosativene (5.1%), sabinene (4.8%), aciphyllene (4.7%), pogostol (4.6%), gamma-terpinene (3.4%), α-muurolol (3.2%) and germecrene d (3.2%). the essential oil exhibited antibacterial activity against propionibacterium acnes atcc 6919 wi ... | 2015 | 26434141 |
| dissecting the taxonomic heterogeneity within propionibacterium acnes: proposal for propionibacterium acnes subsp. acnes subsp. nov. and propionibacterium acnes subsp. elongatum subsp. nov. | propionibacterium acnes subsp. acnes subsp. nov. and propionibacterium acnes subsp. elongatum subsp. nov. are described. these emanate from the three known phylotypes of p. acnes, designated types i, ii and iii. electron microscopy confirmed the filamentous cell shape of type iii, showing a striking difference from types i/ii, which were short rods. biochemical tests indicated that, in types i/ii, either the pyruvate, l-pyrrolidonyl arylamidase or d-ribose 2 test was positive, whereas all of the ... | 2015 | 26432704 |
| propionibacterium acnes isolated from lymph nodes of patients with sarcoidosis. | propionibacterium acnes has been repeatedly suggested as a candidate causative agent of sarcoidosis. it is the only microorganism that has been isolated from sarcoid lesions by bacterial culture so far and this has been described in japanese patients only. we report two non-japanese patients in whom mediastinoscopy was performed in order to obtain lymph node tissue for histopathology, which was suggestive for sarcoidosis. bacterial culture of these uncontaminated mediastinal lymph nodes revealed ... | 2015 | 26422574 |
| preliminary evidence for vitamin d deficiency in nodulocystic acne. | acne vulgaris is a chronic inflammatory disease, and hormonal influences, follicular plugging and follicular hyperkeratinization, increased sebum secretion, propionibacterium acnes colonization, and inflammation are involved in its pathogenesis. recently, a significant body of evidence has accumulated that describes the comedolytic properties of vitamin d and its roles as a modulator of the immune system, a regulator of the proliferation and differentiation of sebocytes and keratinocytes, and as ... | 2017 | 26413187 |
| post-arthroscopy septic arthritis: current data and practical recommendations. | septic arthritis develops after less than 1% of all arthroscopy procedures. the clinical symptoms may resemble those seen after uncomplicated arthroscopy, raising diagnostic challenges. the diagnosis rests on emergent joint aspiration with microscopic smear examination and prolonged culturing on specific media. urgent therapeutic measures must be taken, including abundant arthroscopic lavage, synovectomy, and the concomitant administration of two effective antibiotics for at least 6 weeks. prese ... | 2015 | 26412207 |
| the wound healing and antibacterial activity of five ethnomedical calophyllum inophyllum oils: an alternative therapeutic strategy to treat infected wounds. | calophyllum inophyllum l. (calophyllaceae) is an evergreen tree ethno-medically used along the seashores and islands of the indian and pacific oceans, especially in polynesia. oil extracted from the seeds is traditionally used topically to treat a wide range of skin injuries from burn, scar and infected wounds to skin diseases such as dermatosis, urticaria and eczema. however, very few scientific studies reported and quantified the therapeutic properties of calophyllum inophyllum oil (cio). in t ... | 2015 | 26406588 |
| lubricant and bactericidal properties of calcium salts of fatty acids: effect of degree of unsaturation. | fatty acids containing a c18 alkyl chain such as stearic acid (c18:0 fatty acid), oleic acid (c18:1 fatty acid) and linoleic acid (c18:2 fatty acid) are common emulsifiers in skin-care products and cosmetics and are also used in skin cleansers. in this study, we prepared calcium salts (ca salts) of the above fatty acids to determine the effect of the degree of unsaturation of the alkyl chain. scanning electron microscopy images and x-ray diffraction patterns show that c18:0 and c18:1 fatty acid ... | 2015 | 26369591 |
| insulin resistance in severe acne vulgaris. | acne vulgaris is a pilosebaceous gland disease that usually affects people from puberty to young adulthood. it is seen especially on the face, neck, trunk and arms. its severity differs from patient to patient and its pathogenesis is multifactorial. the main pathogenic factors of acne are high sebaceous gland secretion, follicular hyperproliferation, high androgen effects, propionibacterium acnes colonization and inflammation. diet is always thought a probable reason for acne and many studies ar ... | 2015 | 26366152 |
| cell-free extracts of propionibacterium acnes stimulate cytokine production through activation of p38 mapk and toll-like receptor in sz95 sebocytes. | propionibacterium acnes has been considered to influence the acne lesions. the present study intended to elucidate the underlying signaling pathways of p. acnes in human sebaceous gland cells relative to the generation of proinflammatory cytokines. | 2015 | 26341693 |
| anaerobic prosthetic joint infection. | in an effort to improve mobility and alleviate pain from degenerative and connective tissue joint disease, an increasing number of individuals are undergoing prosthetic joint replacement in the united states. joint replacement is a highly effective intervention, resulting in improved quality of life and increased independence [1]. by 2030, it is predicted that approximately 4 million total hip and knee arthroplasties will be performed yearly in the united states [2]. one of the major complicatio ... | 2015 | 26341272 |
| presence of bacteria in failed anterior cruciate ligament reconstructions. | novel microbial detection technologies have revealed that chronic bacterial biofilms, which are recalcitrant to antibiotic treatment, are common in failed orthopedic procedures. | 2015 | 26339561 |
| solid lipid nanoparticles loaded with retinoic acid and lauric acid as an alternative for topical treatment of acne vulgaris. | topical therapy is the first choice for the treatment of mild to moderate acne and all-trans retinoic acid is one of the most used drugs. the combination of retinoids and antimicrobials is an innovative approach for acne therapy. recently, lauric acid, a saturated fatty acid, has shown strong antimicrobial activity against propionibacterium acnes. however, topical application of retinoic acid is followed by high incidence of side-effects, including erythema and irritation. solid lipid nanopartic ... | 2015 | 26328443 |
| risk factors for surgical site infections after neurosurgery: a focus on the postoperative period. | surgical site infection (ssi) after neurosurgery has potentially devastating consequences. | 2015 | 26300100 |
| relationship between annular tear and presence of propionibacterium acnes in lumbar intervertebral disc. | propionibacterium acnes (p. acnes) in the intervertebral disc may result in low back pain. the purpose of this study was to determine how p. acnes accesses the disc. | 2015 | 26287263 |
| the diversity and host interactions of propionibacterium acnes bacteriophages on human skin. | 2015 | 26283260 | |
| propionibacterium acnes in the pathogenesis and immunotherapy of acne vulgaris. | acne vulgaris, a multi-factorial disease, is one of the most common skin diseases, affecting an estimated 80% of americans at some point during their lives. the gram-positive and anaerobic propionibacterium acnes (p. acnes) bacterium has been implicated in acne inflammation and pathogenesis. therapies for acne vulgaris using antibiotics generally lack bacterial specificity, promote the generation of antibiotic-resistant bacterial strains, and cause adverse effects. immunotherapy against p. acnes ... | 2015 | 26264195 |
| sunscreen remanence on the skin: a noninvasive real time in vivo spectral analysis assessing the quenching of specular ultraviolet a light reflectance. | under specific light illumination, particularly ultraviolet radiation (uvr), the skin produces both specular light reflectance and, possibly, specific fluorescent emission. a quenching effect of fluorescence is observed following the application of sunscreens active against uva radiations. | 2016 | 26260120 |
| propionibacterium acnes recovered from atherosclerotic human carotid arteries undergoes biofilm dispersion and releases lipolytic and proteolytic enzymes in response to norepinephrine challenge in vitro. | in the present study, human atherosclerotic carotid arteries were examined following endarterectomy for the presence of the gram-positive bacterium propionibacterium acnes and its potential association with biofilm structures within the arterial wall. the p. acnes 16s rrna gene was detectable in 4 of 15 carotid artery samples, and viable p. acnes was one among 10 different bacterial species recoverable in culture. fluorescence in situ hybridization analysis of 5 additional atherosclerotic caroti ... | 2015 | 26216428 |
| evaluation of anti-acne properties of phloretin in vitro and in vivo. | this study aimed to investigate the anti-acne properties of phloretin in vitro and in vivo. | 2016 | 26212527 |
| south-east asia study alliance guidelines on the management of acne vulgaris in south-east asian patients. | the management of acne in south-east asia is unique, as asian skin and local variables require a clinical approach unlike that utilized in other parts of the world. there are different treatment guidelines per country in the region, and a group of leading dermatologists from these countries convened to review these guidelines, discuss current practices and recent advances, and formulate consensus guidelines to harmonize the management of acne vulgaris in the region. emphasis has been placed on f ... | 2015 | 26211507 |
| immune response to propionibacterium acnes in patients with sarcoidosis--in vivo and in vitro. | propionibacterium acnes was found in lungs and lymph nodes of patients with sarcoidosis and may induce hypersensitivity type granuloma formation. data regarding the immune response to p. acnes of european sarcoid patients are scarce. | 2015 | 26204953 |
| linking diet to acne metabolomics, inflammation, and comedogenesis: an update. | acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to western diet. three major food classes that promote acne are: 1) hyperglycemic carbohydrates, 2) milk and dairy products, 3) saturated fats including trans-fats and deficient ω-3 polyunsaturated fatty acids (pufas). diet-induced insulin/insulin-like growth factor (igf-1)-signaling is superimposed on elevated igf-1 levels during puberty, thereby unmasking the impact of aberrant nutrigenomics on sebaceous gl ... | 2015 | 26203267 |
| suppression of propionibacterium acnes infection and the associated inflammatory response by the antimicrobial peptide p5 in mice. | the cutaneous inflammation associated with acne vulgaris is caused by the anaerobic bacterium propionibacterium acnes through activation of the innate immune system in the skin. current standard treatments for acne have limitations that include adverse effects and poor efficacy in many patients, making development of a more effective therapy highly desirable. in the present study, we demonstrate the protective effects of a novel customized α-helical cationic peptide, p5, against p. acnes-induced ... | 2015 | 26197393 |
| evaluation of lid speculum with a drape (lidrape(®)) for preventing surgical-field contamination. | to compare the degree of surgical-field contamination in cataract surgeries between a new draping method using a lid speculum with a drape (lidrape(®)) and a conventional draping method. | 2015 | 26185413 |
| multiple splenic nodules with fever: a case of splenic abscess due to propionibacterium acnes. | a 64-year-old man with a history of chronic lymphocytic leukemia (cll) presented in the hematology department due to remarkable leukocytosis and progressing anemia. ultrasound confirmed splenomegaly and plain computed tomography revealed multiple hypoattenuating areas in the large spleen. following a clinical diagnosis of relapse of cll, he underwent treatment with fludarabine, cyclophosphamide, and rituximab (fc-r). after five cycles of fc-r treatment, his leukocyte count and hemoglobin level w ... | 2013 | 26182133 |
| early versus late culture growth of propionibacterium acnes in revision shoulder arthroplasty. | propionibacterium acnes is recognized as a pathogenic organism associated with periprosthetic joint infection following shoulder arthroplasty. the goal of our study was to determine the relationship between the time to p. acnes growth in culture and the likelihood of a culture result being a true positive versus a false positive based on the proportion of positive cultures and other perioperative findings in cases of revision shoulder arthroplasty. | 2015 | 26178890 |
| nitric oxide-releasing nanoparticles prevent propionibacterium acnes-induced inflammation by both clearing the organism and inhibiting microbial stimulation of the innate immune response. | propionibacterium acnes induction of il-1 cytokines through the nlrp3 (nlr, nucleotide oligomerization domain-like receptor) inflammasome was recently highlighted as a dominant etiological factor for acne vulgaris. therefore, therapeutics targeting both the stimulus and the cascade would be ideal. nitric oxide (no), a potent biological messenger, has documented broad-spectrum antimicrobial and immunomodulatory properties. to harness these characteristics to target acne, we used an established na ... | 2015 | 26172313 |
| propionibacterium acnes: a treatable cause of constrictive pericarditis. | in this case report we share a case of infective pericarditis caused by propionibacterium acnes (p. acnes) in an immune-competent, nonsurgical patient. this case and review will illustrate the importance of considering p. acnes as a cause of idiopathic pericardial effusion and effusive constrictive disease. the patient was a 61-year-old male with history of osteoarthritis of the knee. he received an intra-articular steroid injection in july 2013. two months later, he presented with atrial fibril ... | 2015 | 26167179 |
| microbial population dynamics in response to pectobacterium atrosepticum infection in potato tubers. | endophytes are microbes and fungi that live inside plant tissues without damaging the host. herein we examine the dynamic changes in the endophytic bacterial community in potato (solanum tuberosum) tuber in response to pathogenic infection by pectobacterium atrosepticum, which causes soft rot in numerous economically important crops. we quantified community changes using both cultivation and next-generation sequencing of the 16s rrna gene and found that, despite observing significant variability ... | 2015 | 26118792 |
| production of conjugated linoleic acid by heterologous expression of linoleic acid isomerase in oleaginous fungus mortierella alpina. | to increase the commercial value of oleaginous fungus mortierella alpina by incorporation of trans-10,cis-12 conjugated linoleic acid (cla) into the polyunsaturated fatty acids (pufas) of m. alpina via propionibacterium acnes isomerase (pai) conversion. | 2015 | 26109146 |
| vitamin b12 modulates the transcriptome of the skin microbiota in acne pathogenesis. | various diseases have been linked to the human microbiota, but the underlying molecular mechanisms of the microbiota in disease pathogenesis are often poorly understood. using acne as a disease model, we aimed to understand the molecular response of the skin microbiota to host metabolite signaling in disease pathogenesis. metatranscriptomic analysis revealed that the transcriptional profiles of the skin microbiota separated acne patients from healthy individuals. the vitamin b12 biosynthesis pat ... | 2015 | 26109103 |
| propionibacterium acnes catalase induces increased th1 immune response in sarcoidosis patients. | propionibacterium acnes is one of the most commonly implicated etiologic agents of sarcoidosis. we screened antigenic proteins from this indigenous bacterium that increase th1 responses in sarcoidosis patients. | 2015 | 26100176 |
| inhibitory effects of wild bitter melon leaf extract on propionibacterium acnes-induced skin inflammation in mice and cytokine production in vitro. | propionibacterium acnes is a key pathogen involved in acne inflammation. wild bitter melon (wbm, momordica charantia l. var. abbreviate seringe) is consumed as both a vegetable and as folk medicine in taiwan. we examined the inhibitory activity of the total phenolic extract (tpe) of wbm leaf on p. acnes-induced inflammatory responses in vivo and in vitro. our data showed that tpe significantly attenuated p. acnes-induced ear swelling in mice along with microabscess. flow cytometry analysis revea ... | 2015 | 26098998 |
| antimicrobial activity of pomegranate and green tea extract on propionibacterium acnes, propionibacterium granulosum, staphylococcus aureus and staphylococcus epidermidis. | we used pomegranate extract (pomx), pomegranate juice (pom juice) and green tea extract (gt) to establish in vitro activities against bacteria implicated in the pathogenesis of acne. minimum inhibitory concentrations (mic) of 94 propionibacterium acnes, propionibacterium granulosum, staphylococcus aureus, and staphylococcus epidermidis strains were determined by clinical and laboratory standards institute-approved agar dilution technique. total phenolics content of the phytochemicals was determi ... | 2015 | 26091382 |
| fluctuation of bacteria on bleb surface after trabeculectomy with adjunctive mitomycin c. | to determine whether the bacterial and floral patterns on the bleb surface are affected by the season in eyes that had undergone trabeculectomy with adjunctive mitomycin c. | 2016 | 26091180 |
| when is a positive culture in shoulder surgery not an infection? commentary on an article by william r. mook, md, et al.: "the incidence of propionibacterium acnes in open shoulder surgery. a controlled diagnostic study". | 2015 | 26085539 | |
| the incidence of propionibacterium acnes in open shoulder surgery: a controlled diagnostic study. | propionibacterium acnes has arisen as the most common microorganism identified at the time of revision shoulder arthroplasty. there is limited evidence to suggest how frequently false-positive cultures occur. the purpose of this prospective controlled study was to evaluate culture growth from specimens obtained during open shoulder surgery. | 2015 | 26085528 |
| hr-1 mice: a new inflammatory acne mouse model. | there is no appropriate in vivo animal model that reflects the inflammatory response of human acne. | 2015 | 26082581 |
| efficacy of topical benzoyl peroxide on the reduction of propionibacterium acnes during shoulder surgery. | propionibacterium acnes infection is a significant problem after shoulder surgery. residual p. acnes is found on the skin up to 29% of the time immediately after surgical skin preparation and in 70% of dermal biopsy specimens. these residual bacteria may be a source for infection. identifying more ideal skin preparation may help reduce the risk of infection. the purpose of this study was to evaluate the effect that topical benzoyl peroxide (bpo), with chlorhexidine skin preparation, would have o ... | 2015 | 26067191 |
| the absence of fever or leukocytosis does not exclude infection following cranioplasty. | cranioplasty encompasses various cranial reconstruction techniques that are used following craniectomy due to stroke or trauma. despite classical infectious signs, symptoms, and radiologic findings, however, the diagnosis of infection following cranioplasty can be elusive, with the potential to result in definitive treatment delay. we sought to determine if fever or leukocytosis at presentation were indicative of infection, as well as to identify any factors that may limit its applicability. | 2015 | 26062405 |
| clindamycin phosphate 1.2% / tretinoin 0.025%: a novel fixed-dose combination treatment for acne vulgaris. | the global alliance to improve outcomes in acne group recommends retinoid-based combination therapy as first-line therapy and the preferred treatment approach for almost all acne patients except those with the most severe disease. clindamycin 1% (as clindamycin phosphate 1.2%)/tretinoin 0.025% (clin-ra) is a new fixed-dose retinoid-based combination therapy. the aqueous-based gel formulation of clin-ra was designed to minimize skin irritation and optimize adherence with the therapy. it contains ... | 2015 | 26059820 |
| from new findings in acne pathogenesis to new approaches in treatment. | acne is a chronic disease of the pilosebaceous unit which is most common during adolescence. four factors are believed to play a key role in the development of acne lesions: excess sebum production, disturbed keratinization within the follicle, colonization of the pilosebaceous duct by propionibacterium acnes, and the release of inflammatory mediators into the skin. consequently, in order to effectively and rapidly reduce acne lesions, treatments need to address as many of these underlying facto ... | 2015 | 26059819 |
| understanding innate immunity and inflammation in acne: implications for management. | acne has long been understood to have a complex physiological basis involving several main factors: hormonally-stimulated sebum production, abnormal keratinization of the pilosebaceous duct, and an inflammatory immune response to propionibacterium acnes. recent studies at the molecular and cellular level have begun clarifying how all of these factors interact, and the role of the innate immune system is better appreciated. inflammation has been demonstrated in all acne lesions - the preclinical ... | 2015 | 26059728 |
| identification of pathogen signatures in prostate cancer using rna-seq. | infections of the prostate by bacteria, human papillomaviruses, polyomaviruses, xenotropic murine leukemia virus (mlv)-related gammaretroviruses, human cytomegaloviruses and other members of the herpesvirus family have been widely researched. however, many studies have yielded conflicting and controversial results. in this study, we systematically investigated the transcriptomes of human prostate samples for the unique genomic signatures of these pathogens using rna-seq data from both western an ... | 2015 | 26053031 |
| propionic acid produced by propionibacterium acnes strains contri-butes to their pathogenicity. | propionibacterium acnes is an important member of the skin microbiome. the bacterium can initiate signalling events and changes in cellular properties in keratinocytes. the aim of this study was to analyse the effect of the bacterium on an immortalized human keratinocyte cell line. the results show that various p. acnes strains affect the cell-growth properties of these cells differentially, inducing cytotoxicity in a strain-specific and dose-dependent manner. we propose that bacterially secrete ... | 2016 | 26039371 |
| secondary analysis of the nci-60 whole exome sequencing data indicates significant presence of propionibacterium acnes genomic material in leukemia (rpmi-8226) and central nervous system (sf-295, sf-539, and snb-19) cell lines. | the nci-60 human tumor cell line panel has been used in a broad range of cancer research over the last two decades. a landmark 2013 whole exome sequencing study of this panel added an exceptional new resource for cancer biologists. the complementary analysis of the sequencing data produced by this study suggests the presence of propionibacterium acnes genomic sequences in almost half of the datasets, with the highest abundance in the leukemia (rpmi-8226) and central nervous system (sf-295, sf-53 ... | 2015 | 26039084 |
| lactic acid microflora of the gut of snail cornu aspersum. | the intestinal lactic acid microflora of the edible snail cornu aspersum was studied by culture-based methods and was phenotypically and molecularly characterized. the antibacterial activity of lactic acid bacteria (lab) isolates was investigated. snails in different stages of development were collected from farms located in several regions of bulgaria. one hundred twenty-two isolates, belonging to the group of lab, were characterized morphologically and were divided into four groups. representa ... | 2014 | 26019550 |
| the cultivable microbiota of primary and secondary infected root canals, their susceptibility to antibiotics and association with the signs and symptoms of infection. | to examine the presence of microbial species in primary and secondary infections and identify the signs and symptoms associated with them. | 2016 | 26011084 |
| occurrence and new mutations involved in rifampicin-resistant propionibacterium acnes strains isolated from biofilm or device-related infections. | we described for the first time the amino acid substitutions conferring rifampicin resistance in eight propionibacterium acnes strains isolated from patients with biofilm or device-related infections. we identified different mutations in cluster i and one mutation, never reported, in cluster ii of the rpob gene (i480v) associated with the most frequent one in cluster i (s442l). half of the patients previously received treatment with rifampicin. | 2015 | 25999299 |
| a derivative of the thiopeptide ge2270a highly selective against propionibacterium acnes. | a chemical derivative of the thiopeptide ge2270a, designated nai003, was found to possess a substantially reduced antibacterial spectrum in comparison to the parent compound, being active against just a few gram-positive bacteria. in particular, nai003 retained low mics against all tested isolates of propionibacterium acnes and, to a lesser extent, against enterococcus faecalis. furthermore, nai003 showed a time- and dose-dependent killing of both a clindamycin-resistant and a clindamycin-sensit ... | 2015 | 25987631 |
| [bacterial flora in blepharitis]. | blepharitis has multiple, poorly defined origins. the goal of this study was to investigate the bacterial flora present in patients affected with blepharitis in comparison with healthy subjects, so as to understand the role of bacterial etiologies in blepharitis. | 2015 | 25982425 |
| propionibacterium acnes infection in shoulder arthroscopy patients with postoperative pain. | recent studies have identified propionibacterium acnes as the causal organism in an increasing number of postoperative shoulder infections. most reports have found a high rate of p acnes infection after open surgery, particularly shoulder arthroplasty. however, there are limited data regarding p acnes infections after shoulder arthroscopy. | 2015 | 25979553 |
| modulation of th1/th2 immune responses by killed propionibacterium acnes and its soluble polysaccharide fraction in a type i hypersensitivity murine model: induction of different activation status of antigen-presenting cells. | propionibacterium acnes (p. acnes) is a gram-positive anaerobic bacillus present in normal human skin microbiota, which exerts important immunomodulatory effects, when used as heat- or phenol-killed suspensions. we previously demonstrated that heat-killed p. acnes or its soluble polysaccharide (ps), extracted from the bacterium cell wall, suppressed or potentiated the th2 response to ovalbumin (ova) in an immediate hypersensitivity model, depending on the treatment protocol. herein, we investiga ... | 2015 | 25973430 |
| genetic profiles of propionibacterium acnes and identification of a unique transposon with novel insertion sequences in sarcoid and non-sarcoid isolates. | propionibacterium acnes is one of the most commonly implicated etiologic agents of sarcoidosis. we previously reported a complete genome sequence of the c1 strain of p. acnes as a clinical isolate from subcutaneous granulomatous inflammatory lesions in a patient with sarcoidosis. in the present study, we initially searched for genetic profiles specific to the c1 strain by core genome analysis and multiple genome alignment with database sequences from 76 and 9 p. acnes strains, respectively. the ... | 2015 | 25966054 |
| a novel multiple locus variable number of tandem repeat (vntr) analysis (mlva) method for propionibacterium acnes. | propionibacterium acnes plays a central role in the pathogenesis of acne and is responsible for severe opportunistic infections. numerous typing schemes have been developed that allow the identification of phylotypes, but they are often insufficient to differentiate subtypes. to better understand the genetic diversity of this species and to perform epidemiological analyses, high throughput discriminant genotyping techniques are needed. here we describe the development of a multiple locus variabl ... | 2015 | 25965840 |
| typing of the enigmatic propionibacterium acnes. | 2015 | 25963204 |