Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| e hepatitis seroprevalence in a population of patients with transaminases increased at le mans' hospital (france). | in europe, infection through the hepatitis e virus presents itself under the form of autochthone, sporadic cases with zoonotic transmission. the diagnosis is more frequent in the case of male subjects above 50, with a generally severe clinical presentation. moreover, a transition to chronicity is described in the case of immunocompromised patients. in france and in the world, seroprevalence has not clearly been established yet. in the hospital of le mans, sarthe, france, the serologic status reg ... | 2016 | 27237808 |
| hepatitis e virus (hev) orf2 antigen levels differentiate between acute and chronic hev infection. | hepatitis e virus (hev) genotype 3 infections are frequent in europe and north america, with acute and chronic courses described in the literature. hev rna detection by real-time polymerase chain reaction (pcr) is the gold standard for diagnosis. recently, an anti-hev antigen (ag)-specific enzyme-linked immunosorbent assay (elisa) directed against the hev capsid became commercially available. the effectiveness of anti-hev ag-specific elisa at detecting hev genotype 3 infections remains undefined ... | 2016 | 27234418 |
| innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis e virus replication efficiencies. | hepatitis e virus (hev) is a significant health problem in developing countries causing sporadic and epidemic forms of acute viral hepatitis. hepatitis e is a self-limiting disease; however, chronic hev infections are being reported in immunocompromised individuals. the disease severity is more during pregnancy with high mortality (20-25%), especially in third trimester. early cellular responses after hev infection are not completely understood. we analyzed innate immune responses associated wit ... | 2016 | 27230536 |
| hepatitis e virus infection among chronic hemodialysis. | 2016 | 27226872 | |
| hepatitis e virus circulation in italy: phylogenetic and evolutionary analysis. | hepatitis e virus (hev), a major cause of acute viral hepatitis in developing countries, has been classified into four main genotypes and a number of subtypes. new genotypes have been recently identified in various mammals, including hev genotype 3, which has a worldwide distribution. it is widespread among pigs in developed countries. | 2016 | 27226798 |
| in vivo evidence for ribavirin-induced mutagenesis of the hepatitis e virus genome. | hepatitis e virus (hev) infection can take chronic courses in immunocompromised patients potentially leading to liver cirrhosis and liver failure. ribavirin (rbv) is currently the only treatment option for many patients, but treatment failure can occur which has been associated with the appearance of a distinct hev polymerase mutant (g1634r). here, we performed a detailed analysis of hev viral intrahost evolution during chronic hepatitis e infections. | 2016 | 27222534 |
| hepatitis e virus genotype 3 in mussels (mytilus galloprovinciallis), spain. | coastal waters can become contaminated with both human waste from sewage treatment plants and runoff following manure application. thus, shellfish produced close to land can bioaccumulate enteric viruses of human and animal origin, including zoonotic hepatitis e virus that infect both human and swine. the goal of this study was to evaluate the presence of hev in shellfish from galicia (nw spain), a densely populated region with a strong tradition of swine farming, and one of the most important r ... | 2016 | 27217353 |
| the role of hepatitis e virus infection in adult americans with acute liver failure. | acute hepatitis e virus (hev) infection is a leading cause of acute liver failure (alf) in many developing countries, yet rarely identified in western countries. given that antibody testing for hev infection is not routinely obtained, we hypothesized that hev-related alf might be present and unrecognized in north american alf patients. serum samples of 681 adults enrolled in the u.s. acute liver failure study group were tested for anti-hev immunoglobulin (ig) m and anti-hev igg levels. subjects ... | 2016 | 27215797 |
| seroprevalence of parvovirus b19, cytomegalovirus, hepatitis a virus and hepatitis e virus antibodies in haemophiliacs treated exclusively with clotting-factor concentrates considered safe against human immunodeficiency and hepatitis c viruses. | clotting-factor concentrates (cfc) are a potential source of transmission of blood-borne viruses. newer physical and chemical methods (pasteurization, wet-heating, solvent/detergent treating) developed to inactivate viruses are effective against hiv, hbv and hcv. however, it is not clear if these methods protect against other pathogenic viruses such as parvovirus b19, cytomegalovirus (cmv), hepatitis a virus (hav) and hepatitis e virus (hev). to evaluate the safety of current cfc we have studied ... | 1995 | 27214319 |
| thermal stability of hepatitis e virus as estimated by a cell culture method. | hepatitis e virus (hev) is an increasingly recognized zoonotic pathogen. transmission is suspected to occur from infected pigs or wild boars to humans through direct contact, environmental pathways, or contaminated food. however, the physical and chemical stability of hev is largely unknown, because suitable cell culture methods for infectivity measurement are missing. here, we developed a titration method using infection of the cell line a549/d3 with hev genotype 3 strain 47832c and subsequent ... | 2016 | 27208095 |
| hepatitis e: latest developments in knowledge. | hepatitis e, caused by hepatitis e virus (hev), is a highly prevalent disease in developing countries. in developed nations, autochthonous hev infections seem to be an emergent disease. its clinical manifestations and epidemiology are well known for endemic countries. it has been confirmed that hepatitis e is a zoonosis and that parenteral transmission can also occur. the molecular mechanisms of hev replication are not fully understood, mostly because there are no efficient cell culture systems. ... | 2016 | 27203841 |
| experimental infection of rabbits with genotype 3 hepatitis e virus produced both chronicity and kidney injury. | 2017 | 27196597 | |
| multiplex reverse transcriptase-pcr for simultaneous detection of hepatitis b, c, and e virus. | the hepatitis b virus (hbv), hcv, and hev may occur as singly or concurrently in patients of different kind of liver disease. the rapid, reliable, and cost-effective screening of these pathogens is required for the large epidemiological studies. therefore, a study has been planned to develop a multiplex reverse transcriptase-pcr assay which can be used for the screening of maximum number of pathogens at a time. | 2016 | 27194894 |
| acute-on-chronic liver failure (aclf) in coastal eastern india: "a single-center experience". | acute-on-chronic liver failure (aclf) is an emerging entity. the present study was undertaken to analyze the clinical profile and natural course of aclf patients. | 2016 | 27194893 |
| evaluation of the microbiological quality of reclaimed water produced from a lagooning system. | the use of lagooning as a complementary natural method of treating secondary effluents of wastewater treatment plants has been employed as an affordable and easy means of producing reclaimed water. however, using reclaimed water for some purposes, for example, for food irrigation, presents some risks if the effluents contain microbial pathogens. classical bacterial indicators that are used to assess faecal contamination in water do not always properly indicate the presence of bacterial or viral ... | 2016 | 27194016 |
| development and evaluation of two subunit vaccine candidates containing antigens of hepatitis e virus, rotavirus, and astrovirus. | hepatitis e virus (hev), rotavirus (rv), and astrovirus (astv) are important pathogens that transmit through a common fecal-oral route, causing hepatitis (hev) and gastroenteritis (rv and astv) respectively in humans. in this study, we developed and evaluated two subunit vaccine candidates that consisted of the same protruding or spike protein antigens of the three viruses in two formats, a fusion of the three antigens into one molecule (fused vaccine) vs. a mixture of the three free antigens to ... | 2016 | 27194006 |
| prevention strategies for blood-borne viruses-in the era of vaccines, direct acting antivirals and antiretroviral therapy. | blood-borne viruses, such as hepatitis b virus, hepatitis c virus, human immunodeficiency virus, and the facultative blood-borne hepatitis e virus, are considered a major public health problem given that they are accountable for millions of deaths each year. treatment options, including effective vaccine design, development of antiviral strategies and the implementation of antiretroviral therapy have improved substantially over the last couple of years and contribute to successful treatment and ... | 2016 | 27185010 |
| hepatitis e virus: current epidemiology and vaccine. | hepatitis e virus infections have been continuously reported in indian subcontinent, africa, southeast and central asia, posing great health threats to the public, especially to pregnant women. hecolin® is the only licensed hev vaccine developed by xiamen innovax biotech co., ltd. extensive characterizations on antigenicity, physicochemical properties, efficacy in clinical trials, and manufacturing capability have made hecolin® a promising vaccine for hev control. however, there are many obstacl ... | 2016 | 27184971 |
| blood-borne hepatitis e virus transmission: a relevant risk for immunosuppressed patients. | 2016 | 27178472 | |
| hepatitis e virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity. | ribavirin monotherapy is the preferred treatment for chronic hepatitis e, although occasional treatment failure occurs. we present a patient with chronic hepatitis e experiencing ribavirin treatment failure with a completely resistant phenotype. we aimed to identify viral mutations associated with treatment failure and explore the underlying mechanisms. | 2016 | 27174035 |
| acute liver failure - it's just a matter of cell death. | acute liver failure (alf) is characterized by a sudden loss of hepatic function due to hepatocyte cell death and dysfunction in previously healthy individuals. the clinical presentation of alf is associated with coagulopathy (international normalized ratio ≥1.5) and hepatic encephalopathy, although the latter may be less pronounced. without appropriate and timely intensive care or liver transplantation (ltx), alf will result in multi-organ failure and death. various causes may induce alf, with a ... | 2017 | 27170397 |
| hepatitis e virus: time to change the textbooks. | until recently, hepatitis e virus (hev) was thought not to occur in developed countries. it is now clear that locally acquired hev is common in such settings. hev infection acquired in these areas differs from that in developing countries in a number of important aspects: it is caused by genotype 3 (and 4 in china and japan), it mainly affects middle-aged/elderly males and it is zoonotic with a porcine primary host. pig herds worldwide are infected with hev genotype 3 and hev has been found in t ... | 2017 | 27170383 |
| history and global burden of viral hepatitis. | between 1963 and 1989, 5 hepatotropic viruses have been discovered that are the major causes of viral hepatitides worldwide: hepatitis a virus, hepatitis b virus (hbv), hepatitis c virus (hcv), hepatitis delta virus and hepatitis e virus. their epidemiology and pathogenesis have been studied in great detail. furthermore, the structure and genetic organization of their dna or rna genome including the viral life cycle have been elucidated and have been successfully translated into important clinic ... | 2017 | 27170381 |
| hepatitis e virus orf1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion. | hepatitis e virus (hev) is the major causative agent of acute hepatitis in developing countries. its genome has three open reading frames (orfs)-called as orf1, orf2, and orf3. orf1 encodes nonstructural polyprotein having multiple domains, namely: methyltransferase, y domain, protease, macro domain, helicase, and rna-dependent rna polymerase. in the present study, we show that hev-macro domain specifically interacts with light chain subunit of human ferritin (ftl). in cultured hepatoma cells, h ... | 2016 | 27170377 |
| hepatitis e virus in surface water, sediments, and pork products marketed in southern brazil. | hepatitis e virus (hev) is an emerging causative agent of food and waterborne hepatitis in human beings. hev circulates among human populations and swine herds, and may be found in water contaminated by swine feces, as well as in pork. in the present study, 68 sediment samples and 250 water samples collected from the sinos river tributaries, as well as 50 samples of pork products (pâté and blood sausage) marketed in the sinos river watershed region, brazil, were tested for the presence of hev ge ... | 2016 | 27169536 |
| which is safer source plasma for manufacturing in china: apheresis plasma or recovered plasma? | in most countries, the plasma for derivative production includes two types of plasma, apheresis plasma (ap) and recovered plasma (rp). however, the plasma recovered from whole blood is not permitted for manufacture in china. because of the lack of source plasma and the surplus of rp, the chinese government is considering allowing rp as an equivalent source for the production of plasma derivatives. it is known that human blood can be contaminated by various infectious agents. the objective of the ... | 2016 | 27167358 |
| detection of hepatitis e virus in sewage after an outbreak on a french island. | a hepatitis e outbreak, which occurred on a small isolated island, provided an opportunity to evaluate the association between the number of hepatitis e cases in the community and the concentration of virus detected in sewage. samples were collected from the different sewage treatment plants from the island and analyzed for the presence of hepatitis e (hev) virus using real-time rt-pcr. we demonstrated that if 1-4 % of inhabitants connected to a wwtp were infected with hev, raw sewage contained ... | 2016 | 27165600 |
| identification and characterization of avian hepatitis e virus genotype 2 from chickens with hepatitis-splenomegaly syndrome in korea. | a new avian hepatitis e virus (hev) gi-b was identified in broiler breeders with hematomas, liver rupture, and splenomegaly, along with excessive abdominal fat, in korea. previously, genotype 1 had been identified in avian hev strains in korea. complete sequence analyses revealed that the new avian hev clustered in genotype 2, which has been identified in the usa and spain; the gi-b isolate was closely related to the usa prototype avian hev isolated from a chicken with hepatitis-splenomegaly syn ... | 2016 | 27164843 |
| advances in hepatitis e - i: virology, pathogenesis and diagnosis. | infection with hepatitis e virus (hev) is the commonest cause of acute hepatitis worldwide. hev was discovered in 1980s and is known to have small non-enveloped virions with single-stranded rna genome of positive polarity. in recent years. in recent years, availability of new information has changed our understanding of this virus and the pathogenesis of the related disease. | 2016 | 27159083 |
| sero-epidemiological study of hepatitis e virus among thalassemia as high risk patients: a cross-sectional survey in jahrom, southern, iran. | hepatitis e virus (hev) could be cause of viral hepatitis in the developing countries and cause severe epidemics. according to other studies, blood transfusion as a probable route of hev infection has been suggested. an infection with hepatitis agents such as hev causes active liver failure in multi-transfusion patients in particular thalassemia. the purpose of this study determines the seropositivity of anti-hev antibodies in thalassemia individuals in jahrom. in a cross-sectional study, sera f ... | 2016 | 27157168 |
| asialoglycoprotein receptor facilitates infection of plc/prf/5 cells by hev through interaction with orf2. | although the biological and epidemiological features of hepatitis e virus (hev) have been studied extensively in recent years, the mechanism by which hev infects cells is still poorly understood. in this study, coimmunoprecipitation, pull-down, and elisa were used to show that the hev orf2 protein interacts directly with the ectodomain of both asgr1 and asgr2. susceptibility to hev correlated positively with the expression level of surface asialoglycoprotein receptor (asgpr) in cell lines. asgpr ... | 2016 | 27155063 |
| convergent transcription of interferon-stimulated genes by tnf-α and ifn-α augments antiviral activity against hcv and hev. | ifn-α has been used for decades to treat chronic hepatitis b and c, and as an off-label treatment for some cases of hepatitis e virus (hev) infection. tnf-α is another important cytokine involved in inflammatory disease, which can interact with interferon signaling. because interferon-stimulated genes (isgs) are the ultimate antiviral effectors of the interferon signaling, this study aimed to understand the regulation of isg transcription and the antiviral activity by ifn-α and tnf-α. in this st ... | 2016 | 27150018 |
| advances in hepatitis e - ii: epidemiology, clinical manifestations, treatment and prevention. | infection with hepatitis e virus (hev) is the commonest cause of acute hepatitis worldwide. this infection, with fecal-oral transmission, was previously thought to be limited to humans residing in developing countries with poor sanitation, spreading via contaminated drinking water. in recent years, our understanding of epidemiology and clinical spectrum of this infection have changed markedly. | 2016 | 27148907 |
| hepatitis e virus in farmed rabbits, wild rabbits and petting farm rabbits in the netherlands. | rabbits have been suggested as a zoonotic source of hepatitis e virus. phylogenetic analysis of hev isolates from farmed, wild and pet rabbits in the netherlands (23, 0, and 60 % respectively) showed them to be grouped amongst published rabbit hev sequences and distinct from most human isolates. dutch rabbits are unlikely to be a zoonotic source. | 2016 | 27147250 |
| identification of distribution characteristics and epidemic trends of hepatitis e in zhejiang province, china from 2007 to 2012. | hepatitis e virus is a common hepatotropic virus that causes serious gastrointestinal symptoms. data of reported hev cases in zhejiang province was collected between 2007 and 2012. descriptive epidemiological methods and spatial-temporal epidemiological methods were used to investigate the epidemiological trends and identify high-risk regions of hepatitis e infection. in this study, the average morbidity of hepatitis e infection was 4.03 per 100,000 in zhejiang province, peaking in winter and sp ... | 2016 | 27146250 |
| occurrence and prevalence of selected zoonotic agents: echinococcus multilocularis, trichinella spiralis and hepatitis e virus (hev) in the population of polish hunters--results of the study conducted in 2010-2012. | in poland the development of the knowledge concerning zoonotic pathogens, of which free-living animals are the reservoir of is gaining in importance both in epidemiological aspect as well as in the context of prevention for improving public health. dietary habits such as the consumption of forest undergrowth products and wild game meat, and the way of those products being prepared (in the process of barbequing) pose a risk factors of infection with the foodborne pathogens such as echinococcus mu ... | 2015 | 27139343 |
| screening transfusions for hepatitis e virus: is it needed in india? | 2016 | 27132948 | |
| serum levels of soluble cd26, a novel prognostic marker for hepatitis e infection. | even without treatment, most acute hepatitis e virus (hev) infected patients resolve hev but sometimes the disease leads to acute liver failure, chronic infection, or extrahepatic symptoms. the mechanisms of hev pathogenesis appear to be substantially immune mediated. however, the immune responses to hev are not precisely identified. | 2016 | 27127593 |
| farm-level prevalence and risk factors for detection of hepatitis e virus, porcine enteric calicivirus, and rotavirus in canadian finisher pigs. | hepatitis e virus (hev), norovirus (nov), and rotavirus (rv) are all hypothesized to infect humans zoonotically via exposure through swine and pork. our study objectives were to estimate canadian farm-level prevalence of hev, nov [specifically porcine enteric calicivirus (pec)], and rv in finisher pigs, and to study risk factors for farm level viral detection. farms were recruited using the canadian integrated program for antimicrobial resistance surveillance (cipars) and foodnet canada on-farm ... | 2016 | 27127336 |
| a high-throughput neutralizing assay for antibodies and sera against hepatitis e virus. | hepatitis e virus (hev) is the aetiological agent of enterically transmitted hepatitis. the traditional methods for evaluating neutralizing antibody titres against hev are real-time pcr and the immunofluorescence foci assay (ifa), which are poorly repeatable and operationally complicated, factors that limit their applicability to high-throughput assays. in this study, we developed a novel high-throughput neutralizing assay based on biotin-conjugated p239 (hev recombinant capsid proteins, a.a. 36 ... | 2016 | 27122081 |
| identification of critical residues in hepatitis e virus macro domain involved in its interaction with viral methyltransferase and orf3 proteins. | hepatitis e virus (hev) is a major cause of hepatitis in normal and organ transplant individuals. hev open reading frame-1 encodes a polypeptide comprising of the viral nonstructural proteins as well as domains of unknown function such as the macro domain (x-domain), v, duf3729 and y. the macro domain proteins are ubiquitously present from prokaryotes to human and in many positive-strand rna viruses, playing important roles in multiple cellular processes. towards understanding the function of th ... | 2016 | 27113483 |
| hepatitis a virus and hepatitis e virus seroprevalence among blood donors in tehran, iran. | hepatitis a virus (hav) and hepatitis e virus (hev) are both transmitted by the fecal-oral route and are known as the leading causes of acute viral hepatitis in the world, especially in developing countries. there is a lack of updated data on hav and hev seroprevalence in iran. | 2016 | 27110256 |
| apolipoprotein e ε3 and ε4 are associated with a lower exposure to hepatitis e virus in american non-hispanic blacks. | 2016 | 27098729 | |
| neuralgic amyotrophy associated with hepatitis e virus (hev) infection: a case report. | 2016 | 27095100 | |
| uv disinfection and flocculation-chlorination sachets to reduce hepatitis e virus in drinking water. | hepatitis e virus (hev) is a major cause of waterborne outbreaks in areas with poor sanitation. as safe water supplies are the keystone for preventing hev outbreaks, data on the efficacy of disinfection treatments are urgently needed. here, we evaluated the ability of uv radiation and flocculation-chlorination sachets (fcss) to reduce hev in water matrices. the hev-p6-kernow strain was replicated in the hepg2/c3a cell line, and we quantified genome number using qrt-pcr and infectivity using an i ... | 2016 | 27079972 |
| first reported outbreak of locally acquired hepatitis e virus infection in australia. | to determine the source and extent of a locally acquired hepatitis e virus (hev) infection outbreak. | 2016 | 27078603 |
| local transmission of hepatitis e virus in australia: implications for clinicians and public health. | 2016 | 27078590 | |
| reduced glutathione in hepatitis e infection and pregnancy outcome. | to study reduced glutathione (gsh) as a marker of oxidative stress in hepatitis e virus (hev) infection during pregnancy, and to clarify its association with pregnancy outcome. | 2016 | 27075039 |
| c-terminal amino acids 471-507 of avian hepatitis e virus capsid protein are crucial for binding to avian and human cells. | the infection of chickens with avian hepatitis e virus (avian hev) can be asymptomatic or induces clinical signs characterized by increased mortality and decreased egg production in adult birds. due to the lack of an efficient cell culture system for avian hev, the interaction between virus and host cells is still barely understood. in this study, four truncated avian hev capsid proteins (orf2-1 - orf2-4) with an identical 338aa deletion at the n-terminus and gradual deletions from 0, 42, 99 and ... | 2016 | 27073893 |
| hepatitis e virus (hev)-1 harbouring hev-4 non-structural protein (orf1) replicates in transfected porcine kidney cells. | hepatitis e virus (hev) is a causative agent of acute hepatitis and a major public health problem in india. there are four mammalian hev genotypes worldwide. in india, genotype 1 (hev-1) is restricted to humans whereas genotype 4 (hev-4) circulates in pigs. studies from our laboratory have shown that hev-4 (swine) virus can establish experimental infection in rhesus monkeys; however, hev-1 (human) virus cannot infect pigs. viral and/or cellular factors responsible for this host specificity are n ... | 2016 | 27072797 |
| endemicity of zoonotic diseases in pigs and humans in lowland and upland lao pdr: identification of socio-cultural risk factors. | in lao people's democratic republic pigs are kept in close contact with families. human risk of infection with pig zoonoses arises from direct contact and consumption of unsafe pig products. this cross-sectional study was conducted in luang prabang (north) and savannakhet (central-south) provinces. a total of 59 villages, 895 humans and 647 pigs were sampled and serologically tested for zoonotic pathogens including: hepatitis e virus (hev), japanese encephalitis virus (jev) and trichinella spira ... | 2016 | 27070428 |
| fulminant hepatic failure from hepatitis e in a non-pregnant female traveller. | a non-pregnant canadian woman returning from india presented with a 1-week history of jaundice and malaise. subsequently, she developed fulminant hepatic failure caused by hepatitis e virus (hev). hev can cause fulminant hepatic failure, most commonly in pregnant women and those with chronic liver disease; however, all travellers are at risk. | 2016 | 27069000 |
| chronic hepatitis e virus infection after living donor liver transplantation via blood transfusion: a case report. | although it occurs worldwide, hepatitis e virus (hev) infection in developed countries is generally foodborne. hev infection is subclinical in most individuals. although fulminant liver failure may occur, progression to chronic hepatitis is rare. this study describes a 41-year-old man with liver cirrhosis caused by non-alcoholic steatohepatitis and hepatocellular carcinoma within the milan criteria. his liver function was classified as child-pugh grade c. living donor liver transplantation (ldlt ... | 2016 | 27059470 |
| persisting hepatitis e virus infection leading to liver cirrhosis despite recovery of the immune system in an hiv-infected patient. | chronic hepatitis e has been described several times in strongly immunosuppressed hiv-patients. we describe the persistence of hev-infection in an hiv-patient despite a restored immune response. this case demonstrates that hev-infection can persist in formerly immunosuppressed individuals irrespective of the current immune status. persisting hev-infection can lead to chronic inflammation and liver cirrhosis. physicians should be aware of the possibility of chronic hepatitis e even in patients th ... | 2016 | 27055386 |
| hepatitis e virus as an emerging zoonotic pathogen. | hepatitis e outbreaks are a serious public health concern in developing countries. the disease causes acute infections, primarily in young adults. the mortality rate is approximately 2%; however, it can exceed 20% in pregnant women in some regions in india. the causative agent, hepatitis e virus (hev), has been isolated from several animal species, including pigs. hev genotypes 3 and 4 have been isolated from both humans and animals, and are recognized as zoonotic pathogens. seroprevalence studi ... | 2016 | 27051334 |
| hepatitis e in children: a position paper by the espghan hepatology committee. | hepatitis e virus (hev) is endemic in large parts of the developing world. waterborne transmission of genotypes 1 or 2 commonly causes acute hepatitis, which is usually self-limited in healthy individuals. in addition, acute hev infections also occur outside endemic areas, mostly related to foodborne transmission of hev genotype 3. a growing number of publications in the last decade have reported chronic infection progressing to cirrhosis in immunosuppressed patients. it has also been suggested ... | 2016 | 27050048 |
| autochthonous infection with hepatitis e virus related to subtype 3a, france: a case report. | hepatitis e virus (hev) recently emerged in europe as a cause of autochthonous acute hepatitis and a porcine zoonosis. european autochthonous cases almost exclusively involved viruses of genotype 3, subtype 3a being only recently reported in france, from farm pigs. we report an autochthonous human infection with a hev related to subtype 3a in southeastern france. a 55-year-old human immunodeficiency virus-infected man presented liver cytolysis in june 2014. hev rna was detected in serum and thre ... | 2017 | 27049499 |
| the honolulu liver disease cluster at the medical center: its mysteries and challenges. | in 2013, physicians at the honolulu queen's medical center (qmc) noticed that seven liver disease patients reported the use of oxyelite pro (oep), a widely consumed dietary supplement (ds). assuming a temporal association between oep use and disease, they argued that oep was the cause of this mysterious cluster. subsequent reexamination, however, has revealed that this qmc cohort is heterogeneous and not a cluster with a single agent causing a single disease. it is heterogeneous because patients ... | 2016 | 27043544 |
| performance of an antigen assay for diagnosing acute hepatitis e virus genotype 3 infection. | hepatitis e virus (hev) is a major cause of hepatitis worldwide. its diagnosis is based on the detection of anti-hev igm and/or hev-rna. | 2016 | 27038538 |
| endoplasmic reticulum stress induced synthesis of a novel viral factor mediates efficient replication of genotype-1 hepatitis e virus. | hepatitis e virus (hev) causes acute hepatitis in many parts of the world including asia, africa and latin america. though self-limiting in normal individuals, it results in ~30% mortality in infected pregnant women. it has also been reported to cause acute and chronic hepatitis in organ transplant patients. of the seven viral genotypes, genotype-1 virus infects humans and is a major public health concern in south asian countries. sporadic cases of genotype-3 and 4 infection in human and animals ... | 2016 | 27035822 |
| isolation of hepatitis e virus from breast milk during acute infection. | 2016 | 27025819 | |
| a novel blocking elisa for detection of antibodies against hepatitis e virus in domestic pigs. | hepatitis e virus (hev) infects both humans and animals, with an overall human mortality rate generally less than 1%, but as high as 20% among pregnant women. hev strains fall into 4 major genotypes. zoonotic genotypes 3 and 4 associate with sporadic human and animal hev cases in many industrialized countries. to date, collective evidence implicates pigs as the main hev reservoir, justifying the importance of monitoring hev infection rates in pig herds to prevent human illness. due to the lack o ... | 2016 | 27023902 |
| hepatitis e virus seroprevalence among schistosomiasis patients in northeastern brazil. | hepatitis e virus (hev) can cause chronic infection with rapid progression to liver cirrhosis in immunocompromised patients. hev seroprevalence in patients with schistosoma mansoni in brazil is unknown. we evaluated the prevalence of past or present hev infection in schistosomiasis patients in recife, pernambuco, brazil. a total of 80 patients with schistosoma mansoni were consecutively enrolled in a cross-sectional study. serum samples were tested for the presence of anti-hev igg antibodies by ... | 2017 | 27020708 |
| comment on: acute and chronic hepatitis e virus infection in human immunodeficiency virus-infected u.s. women. | 2016 | 27018541 | |
| seroprevalence of hepatitis e virus in autoimmune hepatitis patients in the netherlands. | in recent years chronic courses of hepatitis e virus (hev) infection have been described in immunosuppressed individuals. this may implicate a potential role for hev in the development of autoimmune diseases, including autoimmune hepatitis (aih). here we investigated the prevalence of hev-antibodies in aih patients in an endemic central european country. | 2016 | 27014749 |
| hepatitis e virus infection among solid organ transplant recipients at a north american transplant center. | background. autochthonous hepatitis e virus (hev) infection has been reported in over 200 solid organ transplant (sot) recipients since 2006, yet little is known about the burden of hev among sot recipients in north america. we performed a retrospective, cross-sectional study to investigate the prevalence and risk factors associated with hev infection among sot recipients at our institution. methods. children and adults (n = 311) who received allografts between 1988 and 2012 at the johns hopki ... | 2016 | 27014710 |
| study of hepatitis e virus infection of genotype 1 and 3 in mice with humanised liver. | the hepatitis e virus (hev) is responsible for approximately 20 million infections per year worldwide. although most infected people can spontaneously clear an hev infection, immune-compromised individuals may evolve towards chronicity. chronic hev infection can be cured using ribavirin, but viral isolates with low ribavirin sensitivity have recently been identified. although some hev isolates can be cultured in vitro, in vivo studies are essentially limited to primates and pigs. since the use o ... | 2017 | 27006186 |
| the hepatitis e virus: a likely cause of extrahepatic diseases! | 2016 | 27005693 | |
| extrahepatic manifestations of hepatitis e virus. | hepatitis e virus can cause acute, fulminant and chronic hepatitis and has been associated with a range of extrahepatic manifestations. guillain-barré syndrome, neuralgic amyotrophy and encephalitis are the main neurological manifestations associated with acute and chronic hepatitis e virus infection. renal injuries have been also reported, including membranoproliferative glomerulonephritis with or without cryoglobulinemia and membranous glomerulonephritis. acute pancreatitis, haematological dis ... | 2016 | 27005692 |
| characterization and epitope mapping of monoclonal antibodies raised against rat hepatitis e virus capsid protein: an evaluation of their neutralizing activity in a cell culture system. | hepatitis e virus (hev) is the causative agent of acute hepatitis. rat hev is a recently discovered virus related to, but distinct from, human hev. since laboratory rats can be reproducibly infected with rat hev and a cell culture system has been established for rat hev, this virus may be used as a surrogate virus for human hev, enabling studies on virus replication and mechanism of infection. however, monoclonal antibodies (mabs) against rat hev capsid (orf2) protein are not available. in this ... | 2016 | 26992654 |
| microbiological characterization of a newly established pig breed, aachen minipigs. | to alleviate the shortage of human donor organs or tissues for the treatment of organ and tissue failure including diabetes, pigs are considered suitable donor animals. as organs from conventional pigs are usually too large, those from minipigs may be better suited. we recently characterized the göttingen minipigs, a breed well characterized concerning the presence of zoonotic microorganisms and found hepatitis e virus (hev) and porcine cytomegalovirus (pcmv) in some animals. here, we characteri ... | 2016 | 26991265 |
| new insights into the natural history of hepatitis e virus infection through a longitudinal study of multitransfused immunocompetent patients in france. | little is known about the natural history of hepatitis e virus (hev) infection in immunocompetent individuals. the prevalence, the course of infection and the occurrence of transmission by transfusion were investigated in multitransfused immunocompetent patients/blood donor pairs included in a longitudinal sample repository collection and followed up between 1988 and 2010. ninety-eight subjects aged 6-89 years and suffering from acquired haemoglobinopathies were tested for hev markers (igm, igg ... | 2016 | 26990022 |
| hepatitis e virus and serum level aminotransferases in blood donors. | hepatitis e virus (hev) infection is a self-limiting viral infection that can lead to severe complications and death. in different regions the epidemiology of this infection varies. in this study we evaluated the seroepidemiology of hepatitis e infection in jahrom, a city in southern iran. | 2013 | 26989720 |
| hepatitis e virus prevalence among blood donors, ouagadougou, burkina faso. | 2016 | 26982195 | |
| update on hepatitis e virology: implications for clinical practice. | hepatitis e virus (hev) is a positive-strand rna virus transmitted by the fecal-oral route. the 7.2kb genome encodes three open reading frames (orf) which are translated into (i) the orf1 polyprotein, representing the viral replicase, (ii) the orf2 protein, corresponding to the viral capsid, and (iii) the orf3 protein, a small protein involved in particle secretion. although hev is a non-enveloped virus in bile and feces, it circulates in the bloodstream wrapped in cellular membranes. hev genoty ... | 2016 | 26966047 |
| naked viruses that aren't always naked: quasi-enveloped agents of acute hepatitis. | historically, viruses were considered to be either enveloped or nonenveloped. however, recent work on hepatitis a virus and hepatitis e virus challenges this long-held tenet. whereas these human pathogens are shed in feces as naked nonenveloped virions, recent studies indicate that both circulate in the blood completely masked in membranes during acute infection. these membrane-wrapped virions are as infectious as their naked counterparts, although they do not express a virally encoded protein o ... | 2014 | 26958733 |
| [hepatitis e virus (hev) infection analysis of patients with maintenance haemodialysis]. | 2016 | 26957250 | |
| characterization of seven outbreaks of hemorrhagic hepatopathy syndrome in commercial pullets following the administration of a salmonella enteritidis bacterin in california. | between april 2013 and april 2015, seven flocks belonging to three different major commercial egg producers incalifornia experienced a mild increase in mortality 2 to 3 wk after administration of salmonella enteritidis bacterins. strains of chickens involved were h&n (flock a1, a2, b2, c1, c2, and c3) and lohmann white (flock b1). vaccination was administered individually through injection either in the breast muscles or subcutis in the legs between 11 and 18 wk of age in all flocks. clinical si ... | 2016 | 26953941 |
| conventional and innate lymphocytes response at the acute phase of hev infection in transplanted patients. | the hepatitis e virus (hev) causes usually benign and spontaneously resolving acute hepatitis in immunocompetent individuals. in immunocompromised patients with a solid-organ transplant (sot), chronic infections occur in about 2/3 of cases. we aimed to evaluate the immune cells implicated at the acute phase of hev infection. | 2016 | 26947133 |
| hepatitis e virus infection as a direct cause of neuralgic amyotrophy. | we describe a patient who developed neuralgic amyotrophy (na) related to hepatitis e virus (hev) infection. | 2016 | 26939568 |
| new immunoassays for total, iga and igm antibodies against hepatitis e virus: prevalence in italian blood donors and patients with chronic liver or kidney diseases. | hepatitis e virus (hev) is a zoonotic agent that causes acute hepatitis in humans with sporadic infections and outbreaks in developing countries worldwide. the global spread of hev remains underestimated because of subclinical infections and lack of sensitive diagnostic assays. | 2016 | 26936342 |
| evaluation of rapid tests for diagnosis of acute hepatitis e. | hepatitis e virus diagnosis still presents difficulties due to discordant results among diagnostic tests. | 2016 | 26930580 |
| cross talk between nucleotide synthesis pathways with cellular immunity in constraining hepatitis e virus replication. | viruses are solely dependent on host cells to propagate; therefore, understanding virus-host interaction is important for antiviral drug development. since de novo nucleotide biosynthesis is essentially required for both host cell metabolism and viral replication, specific catalytic enzymes of these pathways have been explored as potential antiviral targets. in this study, we investigated the role of different enzymatic cascades of nucleotide biosynthesis in hepatitis e virus (hev) replication. ... | 2016 | 26926637 |
| transmission of hepatitis e virus by plasma exchange: a case report. | 2016 | 26926359 | |
| serologic evidence for hepatitis e virus infection among patients with undifferentiated acute febrile illness in kibera, kenya. | hepatitis e (hev) is an emerging cause of viral hepatitis mainly transmitted through the fecal-oral route. residents of the kibera slum of nairobi, kenya are at risk for fecal-orally transmitted infections. | 2016 | 26925954 |
| first update of the international xenotransplantation association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--chapter 5: recipient monitoring and response plan for preventing disease transmission. | xenotransplantation of porcine cells, tissues, and organs may be associated with the transmission of porcine microorganisms to the human recipient. a previous, 2009, version of this consensus statement focused on strategies to prevent transmission of porcine endogenous retroviruses (pervs). this version addresses potential transmission of all porcine microorganisms including monitoring of the recipient and provides suggested approaches to the monitoring and prevention of disease transmission. pr ... | 2016 | 26918415 |
| acute viral hepatitis in pediatric age groups. | our clinical experience showed that there has been no decrease in pediatric cases of acute viral hepatitis in kathmandu. the objective of the study was to analyze the etiology, clinical features, laboratory parameters, sonological findings and other to determine the probable prognostic factors of acute viral hepatitis in pediatric population. | 2016 | 26905549 |
| production of hepatitis e virus-like particles presenting multiple foreign epitopes by co-infection of recombinant baculoviruses. | hepatitis e virus (hev) causes not only endemics via a fecal-oral route but also sporadic cases via zoonotic transmission or blood transfusion. hev-like particles (hev-lp) produced by using a baculovirus expression system are considered a candidate for mucosal vaccines for hev infection. in this study, we attempted to produce a chimeric hev-lp presenting various foreign epitopes on its surface. expression of the recombinant capsid proteins carrying a myc- or flag-tag inserted between amino acid ... | 2016 | 26905478 |
| hepatitis e virus is the leading cause of acute viral hepatitis in lothian, scotland. | acute viral hepatitis affects all ages worldwide. hepatitis e virus (hev) is increasingly recognized as a major cause of acute hepatitis in europe. because knowledge of its characteristics is limited, we conducted a retrospective study to outline demographic and clinical features of acute hev in comparison to hepatitis a, b and c in lothian over 28 months (january 2012 to april 2014). a total of 3204 blood samples from patients with suspected acute hepatitis were screened for hepatitis a, b and ... | 2016 | 26904201 |
| a preliminary cost-effectiveness analysis of hepatitis e vaccination among pregnant women in epidemic regions. | objective to estimate the cost-effectiveness of hepatitis e vaccination among pregnant women in epidemic regions. methods a decision tree model was constructed to evaluate the cost-effectiveness of 3 hepatitis e virus vaccination strategies from societal perspectives. the model parameters were estimated on the basis of published studies and experts' experience. sensitivity analysis was used to evaluate the uncertainties of the model. results vaccination was more economically effective on the bas ... | 2016 | 26900799 |
| hepatitis e virus: an ancient hidden enemy in latin america. | hepatitis e virus (hev) infection is a common cause of acute clinical hepatitis worldwide. hev is an rna-containing virus and the only member of the genus hepevirus in the family hepeviridae. human hev is classified into four genotypes widely distributed across the world. the virus is mainly transmitted via the fecal-oral route, and water-borne epidemics have become characteristic of hepatitis e in developing countries, including those in latin america. the zoonotic potential of hev is broadly r ... | 2016 | 26900289 |
| indications of liver biopsy in the era of noninvasive assessment of liver fibrosis. | liver biopsy (lb) has been used as diagnostic modality in liver diseases (ld). over last two decades, there has been remarkable improvement in understanding of natural history, molecular diagnostics of viral hepatitis, genetic of ld, and also limitations of lb. there is current trend in avoiding lb in the management of various lds. | 2015 | 26900273 |
| a mouse model for hepatitis e virus infection. | 2016 | 26892936 | |
| extra-hepatic replication and infection of hepatitis e virus in neuronal-derived cells. | hepatitis e virus (hev) is the causative agent of hepatitis e in humans and a member of the genus orthohepevirus in the family hepeviridae. infection usually leads to acute hepatitis that can become fulminant, particularly among pregnant women and in patients with preexisting liver disease, or may evolve to a chronic state, especially in immunosuppressed individuals. hev has been shown to produce a range of extra-hepatic manifestations including aplastic anaemia, acute thyroiditis, glomeruloneph ... | 2016 | 26891712 |
| risk factors and sources of foodborne hepatitis e virus infection in the united states. | hepatitis e virus (hev) is an important human pathogen with pigs and other species serving as natural animal reservoirs. ample evidence documents sporadic cases of hepatitis e acquired via consumption of undercooked meat. chronic hepatitis e cases in immunosuppressed individuals are mostly caused by zoonotic hev of swine origin. we report here the identification of genotype 3 hev from non-liver commercial pork from local grocery stores in southwest virginia, and association of hev seropositivity ... | 2016 | 26889628 |
| hepatitis e virus (hev) genotype 3 infection of human liver chimeric mice as a model for chronic hev infection. | genotype 3 (gt3) hepatitis e virus (hev) infections are emerging in western countries. immunosuppressed patients are at risk of chronic hev infection and progressive liver damage, but no adequate model system currently mimics this disease course. here we explore the possibilities of in vivo hev studies in a human liver chimeric mouse model (upa(+/+)nod-scid-il2rγ(-/-)) next to the a549 cell culture system, using hev rna-positive edta-plasma, feces, or liver biopsy specimens from 8 immunocompromi ... | 2016 | 26889028 |
| hepatitis e virus genotype 3 in colombia: survey in patients with clinical diagnosis of viral hepatitis. | hepatitis e virus is a major cause of outbreaks as well as sporadic hepatitis cases worldwide. the epidemiology of this enterically transmitted infection differs between developing and developed countries. the aims of this study were to describe hev infection in colombian patients and to characterize the genotype. | 2016 | 26886728 |
| characterization of hepatitis e virus infection in tree shrew (tupaia belangeri chinensis). | hepatitis e virus (hev) is a major cause of hepatitis in developing countries and poses a threat to public health worldwide. tree shrew (tupaia belangeri chinensis) is a useful animal model in studies on hepatitis viruses, such as hepatitis b and c viruses. however, the use of this animal model for hev research is yet to be developed. | 2016 | 26880187 |
| prevalence of hepatitis e virus (hev) antibodies in mexican pigs. | the hepatitis e virus (hev) is the causative agent of hepatitis e, an enterically transmitted disease. hev infections in pigs and humans have been reported worldwide, but data from mexico are scarce. in the present study, the prevalence of anti-hev igg antibodies was investigated in a quite large number of swine from mexico by means of an elisa based on a recombinant open reading frame 2 protein of hev genotype 3. serum samples from 683 healthy pigs (1-48 months old), collected during 2010-2013 ... | 2016 | 26880004 |
| serological survey of hepatitis e virus infection in farmed and pet rabbits in italy. | the recent identification in rabbits of hepatitis e viruses (hev) related to viruses infecting humans raises the question of the role of this species as possible hev reservoir. a serological survey on rabbit hev infection was conducted in italy during 2013-2014, including both farmed and pet rabbits. we found an anti-hev antibody seroprevalence of 3.40 % in 206 farmed rabbits (collected on 7 farms) and 6.56 % in 122 pets. rna was extracted from igg-positive sera and analyzed by hev-specific real ... | 2016 | 26873813 |