Publications

the genetic revolution at work: legislative efforts to protect employees.		2002	12197465
us refuses to issue entry visas to people with hiv / aids.	the us government, ignoring the almost unanimous recommendation of medical and public health experts throughout the world, continues to ban both immigration and travel by people with hiv. following recommendations from the us centers for disease control and prevention, the us department of health and human services indicated its intention to reduce the list of dangerous and contagious diseases for excluding entry to the us to include only active tuberculosis. that decision would have removed h ...	1991	12179700
the new york times ad.	feminization of patriarchal institutions is necessary in order to eliminate the exclusivity and mutuality of hierarchical, gender, class, and race stratification. the aim of this paper is to explain the history and activities surrounding the new york times ad on sunday, october 7, 1984 (the catholic statement on pluralism and abortion signed by barbara ferraro and patricia hussey of the sisters of note dame de namur, rose dominic trapasso of the maryknoll sisters, and 67 other signers). the si ...	1993	12178920
an instrument for determining the amount of nih support for clinical investigations at one academic health center.	although interest in supporting clinical investigators is increasing, information regarding the quantity, spectrum, and specific types of clinical research performed in academic health centers (ahcs) is generally not available. the authors report on an instrument to quantify the national institutes of health (nih)-funded component of clinical research at one institution.	2002	12176698
mental retardation research center at boston children's hospital/harvard medical school. introductory overview.	the mrrc at children's hospital/harvard medical school is focused on research in genetics and neuroscience. both clinical and basic science approaches are abundant. major interdisciplinary programs, particularly in the areas of neonatal brain injury, human cerebral cortical malformations, and human neuromuscular disorders, interdigitate basic and clinical research in cohesive research programs. the core research support facilities serve as the nidus for this large research effort, encompassing 6 ...	2002	12175871
quantification of respirable, thoracic, and inhalable quartz exposures by ft-ir in personal impactor samples from construction sites.	the classification of quartz as a group i human carcinogen by the international agency for research on cancer (iarc) highlights the need to develop a method to assess quartz exposures in the thoracic and inhalable particle size fractions to supplement the current method for the respirable size fraction. heavy and highway construction operations can produce high respirable quartz exposures, but inhalable and thoracic exposures have not previously been well characterized. these larger particle siz ...	2002	12166893
just-in-time delivery comes to knowledge management.	like all primary care physicians, dr. bob goldszer must stay on top of approximately 10,000 different diseases and syndromes, 3,000 medications, 1,100 laboratory tests, and many of the 400,000 articles added each year to the biomedical literature. that's no easy task. and it is, quite literally, a matter of life and death. the institute of medicine's 1999 report, to err is human, suggests that more than a million injuries, and 90,000 deaths are attributable to medical errors annually. something ...	2002	12140850
incidence, outcome, and long-term consequences of herpes simplex virus type 1 reactivation presenting as a facial rash in intubated adult burn patients treated with acyclovir.	increased mortality, extensive visceral involvement, and necrotizing tracheobronchitis associated with herpes viruses have been reported after burns. it is unclear whether herpes presenting as a facial rash results in outcome changes after burns.	2002	12131395
evidence for heritability of abdominal aortic calcific deposits in the framingham heart study.	atherosclerosis is a systemic disease that underlies clinical cardiovascular disease. the radiographic finding of abdominal aortic calcific deposits is an indicator of the presence of aortic atherosclerosis and an independent predictor of cardiovascular disease events. little is known about the heritability of aortic calcification.	2002	12119250
case records of the massachusetts general hospital. weekly clinicopathological exercises. case 20-2002. a 37-year-old man with fever, hepatosplenomegaly, and a cutaneous foot lesion after a trip to africa.		2002	12087144
use of physical, chemical, and biological indices to assess impacts of contaminants and physical habitat alteration in urban streams.	human activities in urban areas can lead to both chemical pollution and physical alteration of stream habitats. the evaluation of ecological impacts on urban streams can be problematic where both types of degradation occur. effects of contaminants, for example, may be masked if stream channelization, loss of riparian vegetation, or other physical stressors exert comparable or larger influences. in the aberjona watershed (near boston, ma, usa), we used physical, chemical, and biological indices t ...	2002	12069298
experimentation on human fetuses prohibited; medical procedures authorized; consent; approval; civil and criminal liability and proceedings; severability.		1976	12041355
an act prohibiting experimentation on human fetuses. approved 26 jun 1974.		1974	12041354
rust v. sullivan.	the federal public health service act specifies that no title x funds used for family planning services "shall be used in programs where abortion is a method of family planning." in 1988, the secretary of health and human services promulgated regulations that prohibited title x projects from abortion counseling, referral, or advocacy. various title x doctors sued, alleging violations of their first and fifth amendment rights. the supreme court found the regulations to be a permissible constru ...	1991	12041295
care and protection of beth.	the supreme judicial court of massachusetts upheld the lower court's "do not resuscitate" (dnr) order regarding a five-year-old child who had been in an irreversible coma since infancy. although dnr orders generally do not require judicial review, the fact that both parents were minors and the mother and child were in the custody of the department of social services necessitated judicial involvement. using the doctrine of substituted judgment, the court determined that the incompetent child woul ...	1992	12041221
commonwealth v. cass.	the massachusetts supreme judicial court decided the question of whether a viable fetus is a "person" for purposes of the vehicular homicide statute in massachusetts. although the common law rule in every american jurisdiction that has considered the question, including massachusetts, has been that the destruction of the fetus in utero is not homicide, the supreme judicial court ruled to the contrary. confident in the ability of medical science to provide competent proof as to whether the cond ...	1984	12041184
commonwealth v. edelin. 17 dec 1976.		1976	12038352
implementing the precautionary principle.	the precautionary principle can be found in international treaties that protect human health and the environment from a variety of pollutants and perturbations. one of the earliest forms of the precautionary principle was used in the 1980s in europe to protect the north sea. in 1992, the rio declaration specifically included the precautionary principle in calling on nations to protect the environment. the us articulation that best embodies this approach to environment and human health protection ...	2002	12013543
prevalence of enterocytozoon bieneusi in swine: an 18-month survey at a slaughterhouse in massachusetts.	slaughterhouse pig samples were analyzed by pcr for enterocytozoon bieneusi infection. thirty-two percent were found to be positive, with rates being higher over the summer months. three isolates from pigs were identical in their ribosomal internal transcribed spacer sequence to human e. bieneusi type d, two were identical to type f (from a pig), and nine were previously unreported. the viability of these spores was demonstrated by their ability to infect gnotobiotic piglets. the presence of the ...	2002	11976142
identifying undiagnosed human immunodeficiency virus: the yield of routine, voluntary inpatient testing.	despite current recommendations for human immunodeficiency virus (hiv) counseling and testing among patients admitted to hospitals with at least a 1% prevalence of hiv infection, an estimated 300 000 people in the united states remain unaware of their hiv infection.	2002	11966339
particulate matter and polycyclic aromatic hydrocarbon concentrations in indoor and outdoor microenvironments in boston, massachusetts.	estimating personal exposures to air pollution is a crucial component in identifying high-risk populations and determining efficient control strategies. because of the difficulty of comprehensively measuring personal exposure, data on air pollution patterns in homogenous microenvironments linked with activity data are often used as surrogates. in this study, we focus on strengthening the available information about nonresidential microenvironmental exposures to particulate matter and other combu ...	2002	11965527
using gis and historical records to reconstruct residential exposure to large-scale pesticide application.	investigation of pesticide impacts on human health depends on good measures of exposure. historical exposure data are needed to study health outcomes, such as cancer, that involve long latency periods, and other outcomes that are a function of the timing of exposure. environmental or biological samples collected at the time of epidemiologic study may not represent historical exposure levels. to study the relationship between residential exposure to pesticides and breast cancer on cape cod, massa ...	2002	11859434
the menopause experience: a woman's perspective.	to understand the complexities of the experience of menopause in american women from diverse ethnic and socioeconomic backgrounds. the specific aims of this phenomenologic study were to (a) examine and interpret the reality of the menopausal transition as experienced by american women and (b) identify common elements and themes that occur as a result of the complexities of this experience.	2002	11843022
us: court refuses to order disclosure of hiv status to police.	in february 2001, massachusetts' highest court ruled that a man whose blood was splattered on police officers during his arrest is protected under that state's law from having to reveal his hiv status.	2001	11837039
sources and species of cryptosporidium oocysts in the wachusett reservoir watershed.	understanding the behavior of cryptosporidium oocysts in the environment is critical to developing improved watershed management practices for protection of the public from waterborne cryptosporidiosis. analytical methods of improved specificity and sensitivity are essential to this task. we developed a nested pcr-restriction fragment length polymorphism assay that allows detection of a single oocyst in environmental samples and differentiates the human pathogen cryptosporidium parvum from other ...	2002	11823192
structure and seasonality of nearctic culex pipiens populations.	the abundance and structure of urban autogenous and anautogenous populations of culex pipiens mosquitoes were documented systematically in boston, ma, during three successive years. autogenous larvae become abundant mainly in enclosed sites and anautogenous larvae in sites that provide free access and egress. both populations begin to proliferate when the water temperature exceeds 15 degrees c during june. larval anautogenous mosquitoes increase in abundance 10-fold in two weeks and autogenous i ...	2001	11797779
human milk lipids bind shiga toxin.	hemolytic uremic syndrome, a serious complication of shiga toxin-associated diarrhea, is rare before 6 months of age. immunologic and nonimmunologic factors present in human milk may partially explain this observation. in prior studies, we have demonstrated that human milk contains gb3, the receptor for the b subunit of shiga toxin, and also contains secretory iga (siga) against the toxin. we therefore sought to determine the relative importance of milk glycolipid and toxin-specific siga in toxi ...	2001	11787699
rabies surveillance in the united states during 2000.	during 2000, 49 states, the district of columbia, and puerto rico reported 7,364 cases of rabies in nonhuman animals and 5 cases in human beings to the centers for disease control and prevention, an increase of 4.3% from 7,067 cases in nonhuman animals reported in 1999. ninety-three percent (6,855 cases) were in wild animals, whereas 6.9% (509 cases) were in domestic species (compared wth 91.5% in wild animals and 8.5% in domestic species in 1999). compared with cases reported in 1999, the numbe ...	2001	11767918
an outbreak of primary pneumonic tularemia on martha's vineyard.	in the summer of 2000, an outbreak of primary pneumonic tularemia occurred on martha's vineyard, massachusetts. the only previously reported outbreak of pneumonic tularemia in the united states also occurred on the island in 1978.	2001	11757506
ige and igg antibody responses to recombinant alt a 1 as a marker of sensitization to alternaria in asthma and atopic dermatitis.	sensitization to alternaria alternata is a risk factor for the development of wheezing and asthma. alt a 1 is the major alternaria allergen causing sensitization in asthmatics. some atopic dermatitis (ad) patients have very high immunoglobulin (ig)e antibody (ab) to alternaria as analysed by pharmacia cap, however, it is not clear whether these are specific responses or whether alt a 1 is involved in disease symptoms.	2001	11737041
blood lead levels in relation to paint and dust lead levels: the lead-safe cambridge program.		2001	11726378
the treating physician as active gatekeeper in the recruitment of research subjects.	institutional review boards vary in regard to the conditions imposed on investigators concerning contacting potential subjects to participate in health-services research studies.	2001	11717575
mbd, drug research and the schools: a conference on medical responsibility and community control, 13-14 feb 1976.		1976	11678140
psychosurgery in massachusetts: a task force report.		1975	11664587
ethical problems in fetal research.		1975	11664449
foetal research aborted in united states.		1974	11664375
dr. edelin cleared by appeals court.		1977	11663717
boston md--neighbors exemplify divergent views in abortion debate.		1976	11663681
fetal research iv: the living fetus and the law--the state's role.		1975	11663566
from comstockery through population control: the inevitability of balancing.		1974	11663527
abortion and the law: equal protection.		1973	11663435
student research in service agencies.		1978	11661773
radiation experiments on children at the fernald and wrentham schools: lessons for protocols in human subject research.		1998	11660586
the law of patient care in massachusetts.		1983	11658444
whatever made them do it?		1995	11656388
understanding abortion via different scholarly methodologies: book review essay.	erde review three works that in his opinion have made important contributions to the abortion debate: abortion policy: an evaluation of the consequences for maternal and infant health, by jerome s. legge, jr. (albany: state university of new york press; 1985); abortion and the politics of motherhood, by kristen luker (berkeley: university of california press; 1984); and abortion: moral and legal perspective, edited by j.l. garfield and p. hennessey (amherst: university of massachusetts press; ...	1986	11655806
nuclear weapons: us research put to vote.	a statute banning nuclear weapons research in cambridge, massachusetts, is scheduled for a referendum vote in november 1983. if passed, the act would require the city to fine or imprison violators after the ban takes effect in october 1985, and could have an impact on work done at harvard university and the massachusetts institute of technology, as well as at the charles stark draper laboratory. lawyers for draper and the local anti-nuclear group that drafted the statute, mobilization for surv ...	1983	11653480
improving the readability of informed consent documents.		1993	11652152
being a physician and being ethical.		1992	11651450
state constitutions: the new battlefield for abortion rights.		1987	11649953
mother v. her unborn child: where should texas draw the line?		1987	11649225
judicial recognition of feticide: usurping the power of the legislature?		1986	11649213
massachusetts v. secretary of health and human services.	the plaintiffs challenged the validity of regulations, promulgated under title x of the public health service act, that prohibit funding of nondirective abortion counseling or referral and demand separation of funded projects from projects which encourage abortion. the plaintiffs argued that the regulations unconstitutionally burden a woman's choice because they impermissibly restrict the information received during pregnancy counseling. distinguishing between refusals to fund abortion and in ...	1990	11648391
commonwealth of massachusetts v. bowen.	the u.s. department of health and human services (dhhs) promulgated regulations on 2 feb 1988 prohibiting the use of any federal funds by health clinics that engage in abortion counseling and referral or in abortion lobbying and advocacy, even if the clinics make use of nonfederal funds for these activities. the u.s. district court, d. massachusetts, found that the regulations violated both constitutional rights, under the first amendment in particular, and congressional intent. the court issu ...	1988	11648376
a sound way to curtail abortion.		1985	11647360
manufacturer admits selling untested devices for heart.		1993	11647008
court says feeding may stop for man in a vegetative state.		1986	11646483
legal trends in bioethics.		1996	11644885
experiment perilous: forty-five years as a participant observer of patient-oriented clinical research.		1996	11644830
fetal research (iii): the impact of a massachusetts law.		1975	11643265
fetal research (ii): the nature of a massachusetts law.		1975	11643261
fetal research: the case history of a massachusetts law.		1975	11643258
child study at clark university: 1894-1904.		1990	11607967
the applications of capture-recapture models to epidemiological data.	capture-recapture methodology, originally developed for estimating demographic parameters of animal populations, has been applied to human populations. this tutorial reviews various closed capture-recapture models which are applicable to ascertainment data for estimating the size of a target population based on several incomplete lists of individuals. most epidemiological approaches merging different lists and eliminating duplicate cases are likely to be biased downwards. that is, the final merg ...	2001	11590637
sample exchange to compare insulin measurements between the san antonio heart study and the framingham offspring study.	lack of assay standardization has precluded cross-study comparison of insulin levels. we exchanged blood samples between the san antonio heart and framingham offspring studies to compare insulin measurements. two randomly selected specimens were chosen for each non-diabetic man and woman in each of the bottom four quintiles and top two deciles of the originally assayed fasting and 2-hour post-challenge insulin distributions: 48 plasma samples from framingham, and after further stratification by ...	2001	11576815
muscle power of the ankle flexors predicts functional performance in community-dwelling older women.	to test the hypothesis that peak power of the ankle flexors is related to physical functioning in older women with functional limitations.	2001	11559374
the motor unit and electromyography--the legacy of derek denny-brown.	with the development of the concept of the motor unit and new recording instruments, single motor unit action potentials (muaps) were recorded in 1929 in man by adrian and bronk and in the experimental animal by denny-brown. studies of muaps in patients with neuromuscular disease followed, and in 1938, denny-brown and pennybacker laid the foundation for clinical electromyography (emg). action potentials of single contracting or spontaneously firing motor units, termed fasciculations, were record ...	2001	11535228
baby-friendly hospital initiative improves breastfeeding initiation rates in a us hospital setting.	breastfeeding initiation rates were compared at boston medical center before (1995), during (1998), and after (1999) baby-friendly policies were in place. boston medical center, an inner-city teaching hospital that provides care primarily to poor, minority, and immigrant families, achieved baby-friendly status in 1999.	2001	11533335
robley evans and what physics can do for medicine.	when asked, in 1936 by j. howard means, chief of medicine at massachusetts general hospital, whether radioiodine could be produced for thyroid studies, karl t. compton, president of the massachusetts institute of technology, referred the question to robley evans of the physics department. in response, evans formed a team from the fields of physics and medicine that produced 128i for animal studies and, subsequently on a cyclotron dedicated to medical purposes, 130i for human uptake measurements ...	2001	11471483
management of patients with chronic renal insufficiency in the northeastern united states.	comorbid conditions that develop during chronic renal insufficiency (cri) contribute to the high morbidity and mortality among patients with end-stage renal disease (esrd). thus, appropriate management during cri may lead to improved esrd outcomes. a retrospective cohort study was performed to describe the management of patients with cri. a total of 602 patients with cri (creatinine > or =1.5 mg/dl for women and > or =2.0 mg/dl for men) were seen between october 1994 and september 1998 at five n ...	2001	11423579
association of the ala54-thr polymorphism in the intestinal fatty acid-binding protein with 2-h postchallenge insulin levels in the framingham offspring study.	to investigate the association of variants of the intestinal fatty acid-binding protein gene (fabp2) with fasting and postchallenge glucose and insulin levels, hba(1c), and prevalence of type 2 diabetes in a separate sample of men and women.	2001	11423496
uv doses of americans.	the uv doses of americans were never measured, but are needed for assessing the risks of uv-related health effects. we calculated these doses using a novel approach. the environmental protection agency's (epa) national human activity pattern survey (nhaps) recorded the activity profiles of 9386 americans over 24 months to assess their exposure to environmental pollutants, one of which is uv radiation. nhaps used randomized telephone interviews to get their previous day's minute-by-minute activit ...	2001	11421067
mastering the value chain. an interview with mark levin of millennium pharmaceuticals. interview by david champion.	as today's business leaders are all too aware, a new scientific or technological break-through can quickly transform an industry's competitive landscape. the upheaval is often traumatic for the companies involved, forcing them to rethink their strategies and redefine their boundaries. but an industry in flux also creates vast opportunities. to seize them, companies must see how the current upheavals will affect the future distribution of profits--and then reinvent themselves to capitalize on the ...	2001	11408971
managing health care variability to achieve quality care.	while much has been written about variation and health care, one area that has received little attention is variation within hospitals related to the operations management--which can lead to wasted money and human resources. two boston researchers who have been studying this area say that addressing these variations--and using techniques found in other major industries across the country--could give hospitals a new tool in addressing patient safety issues, nursing shortages, cost containment, an ...	2001	11400326
developing leadership in healthcare administration: a competency assessment tool.	despite the many graduate programs that specialize in health administration, healthcare leaders and practitioners have expressed concern about the quality of preparation of health administration graduates. the purpose of this study was to facilitate one part of an integrated approach to leadership development that spans academic and practitioner settings. the approach was to design a competency assessment tool for early careerists who have two to five years of postgraduate experience and who asp ...	2001	11372221
criminal exposure.	in august, an hiv-positive man plead guilty to sexually assaulting a 14-year-old boy. the sleeping boy awoke to find james muise sexually assaulting him, while watching a pornographic video. muise plead guilty to the assault with intent to rape a child. in addition, muise received three counts of indecent assault and battery on a child, and exposure of pornographic material to a minor. muise will remain on probation for five years, although the prosecution had recommended sentencing muise to fou ...	1999	11366904
annual colposcopies and pap smears recommended for women with hiv.	a new study presented by annekathryn goodman of massachusetts general hospital indicates that hiv positive women should receive annual colposcopies, along with pap smears, to detect abnormal cell growth early. the recommendation is due to the fact that hiv positive women are more likely to have false-negative pap smears than hiv negative women. in a related development, the fda approved a new dna-based blood test to detect human papillomavirus, which is associated with cervical and anal cancer. ...	1999	11366700
court sees no basis to void policy issued to man with hiv.	the massachusetts supreme judicial court found that protective life insurance company cannot rescind a policy if it failed to detect fraud within a two-year contestability period. the court ruled that the insurer should have exercised reasonable diligence when conducting the medical exam of dennis j. sullivan one year after he tested positive for hiv-antibodies. sullivan lied about his health on the insurance application and omitted the names of the doctors who had been treating him for hiv. sul ...	1997	11364602
doctor withheld prenatal care to woman with hiv, suit says.	when vickie lesley's routine hiv test came back positive, her obstetrician/gynecologist said she must transfer to a high-risk clinic for her prenatal care. lesley filed suit against dr. hee man chie for discontinuing treatment and for refusing to provide azt. the refusal to provide prenatal care violates the americans with disabilities act (ada), the rehabilitation act, and chapter 272, section 98 of the massachusetts public accommodations law. under the statute, a doctor may not automatically t ...	1997	11364309
lawsuit filed.	social service providers at a boston center for haitian immigrants filed a suit in a u.s. district court against the federal government. the suit claims that auditors from the inspector general's office in the u.s. department of health and human services demanded the names of clients with aids. the auditors explained that this process, conducted to determine whether agencies are properly spending ryan white care act funds, is appropriate and routine. attorneys for the social service providers co ...	1996	11363287
court lets stand ruling on condoms, insurance and azt.	in three aids-related cases, the u.s. supreme court has let the decisions stand. the three cases are: curtis v. school committee of falmouth, allowing the availability of condoms in a massachusetts public school; fioretti v. massachusetts general life insurance co., invalidating a life insurance policy issued to a man with aids who used a stand-in to pass an hiv-antibody test to qualify for coverage; and barr laboratories v. burroughs wellcome co., preventing generic drug manufacturers from ente ...	1996	11363161
court upholds voiding of insurance policy based on fraud.	a federal appeals court has determined that an insurer acted properly in refusing to pay life insurance benefits to the survivor of a man with aids who fraudulently obtained the insurance. the eleventh u.s. circuit court of appeals said the late anthony c. fioretti fraudulently obtained the policy from massachusetts general life insurance company in 1986 when he applied for an $1.9 million policy. to qualify for the coverage, fioretti used an hiv-negative individual to pass an hiv-antibody test. ...	1995	11362709
boston: important trial of treatment vaccine, cd4 over 500.	a trial at beth israel hospital of boston is seeking eighteen volunteers for a new hiv treatment vaccine. the vaccine is a peptide found in hiv, is chemically synthesized, is not from live hiv, and appears to be safe. the 68-week placebo-controlled study is called hiv lipopeptide immunotherapeutic in hiv-1 seropositive human subjects. the study requires volunteers to have cd4 counts over 500, no antiretroviral use for six months prior to entering the study, no use of immunosuppressive agents, no ...	1995	11362626
a mobile hiv education and testing program: bringing services to hard-to-reach populations.	few programs exist that offer a range of human immunodeficiency virus (hiv) services to multiple populations (i.e., substance abusers, individuals on probation, sex workers and their clients, court-mandated perpetrators of domestic violence) in multiple settings (i.e., courts, methadone maintenance clinics, residential and outpatient substance abuse treatment programs). the purpose of this article is to describe a model mobile hiv program, highlighting its flexibility in providing services to cl ...	1998	11362065
an investigation of why eligible patients do not receive haart.	treatment with highly active antiretroviral therapy (haart) decreases morbidity and mortality for persons with human immunodeficiency virus/acquired immunodeficiency syndrome (hiv/aids) and reduces costs of care. yet many patients for whom haart is indicated do not receive it. this study investigated the reasons why certain patients of a community health center with hiv/aids did not receive haart between 1997 and 1998. medical record reviews were performed to determine which patients for whom ha ...	2001	11359660
enzootic transmission of deer tick virus in new england and wisconsin sites.	to determine whether rodents that are intensely exposed to the deer tick-transmitted agents of lyme disease, human granulocytic ehrlichiosis, and human babesiosis are also exposed to deer tick virus (dtv), we assayed serum samples from white-footed mice (peromyscus leucopus) and meadow voles (microtus pennsylvanicus) in sites densely infested by deer ticks. to conduct serosurveys, we developed an enzyme-linked immunosorbent assay (elisa) and western blot assay by cloning, expressing, and purifyi ...	2000	11357992
tufts man of the century, dr. j. murray gavel.		2000	11324041
john m. kinney international awards. looking back: a human reason for studying the effects of glutamine in patients with aids.		2001	11312061
bach1, a novel helicase-like protein, interacts directly with brca1 and contributes to its dna repair function.	brca1 interacts in vivo with a novel protein, bach1, a member of the deah helicase family. bach1 binds directly to the brct repeats of brca1. a bach1 derivative, bearing a mutation in a residue that was essential for catalytic function in other helicases, interfered with normal double-strand break repair in a manner that was dependent on its brca1 binding function. thus, bach1/brca1 complex formation contributes to a key brca1 activity. in addition, germline bach1 mutations affecting the helicas ...	2001	11301010
evolution of depressive symptoms in human immunodeficiency virus-infected patients entering primary care.	our purpose was to examine among hiv-infected patients a) characteristics associated with depressive symptoms at initial primary care presentation and b) factors associated with improvement in depressive symptoms. we interviewed hiv-infected patients at initial presentation and reassessed them 6 months later. at baseline and follow-up, we collected data on depressive symptoms (ces-d) and other characteristics. using multiple linear regression, we examined associations between ces-d score and bas ...	2001	11225690
switching doctors: predictors of voluntary disenrollment from a primary physician's practice.	our objective was to evaluate 8 interpersonal and structural features of care as predictors of patients' voluntary disenrollment from their primary care physician's practice.	2001	11219560
babesiosis.	a case of human babesiosis is presented. this case emphasizes the need to consider tick-borne disease in anyone who presents with prolonged and undulating fevers, chills, headache, myalgias, and arthralgias. this holds true particularly in areas endemic for tick-borne diseases, even in the absence of a history of tick bite. these symptoms, associated with signs of intravascular hemolysis, thrombocytopenia, and renal insufficiency in a patient who resides in, or with recent travel to, the northea ...	2001	11165832
building a better human.		2000	11147306
emergence of domestically acquired ceftriaxone-resistant salmonella infections associated with ampc beta-lactamase.	ceftriaxone, an expanded-spectrum cephalosporin, is an antimicrobial agent commonly used to treat severe salmonella infections, especially in children. ceftriaxone-resistant salmonella infections have recently been reported in the united states, but the extent of the problem is unknown.	2000	11135779
rabies surveillance in the united states during 1999.	during 1999, 49 states, the district of columbia, and puerto rico reported 7,067 cases of rabies in nonhuman animals to the centers for disease control and prevention, a decrease of 11.2% from 7,961 cases in nonhuman animals and 1 case in a human being reported in 1998. more than 91% (6,466 cases) were in wild animals, whereas 8.5% (601 cases) were in domestic species (compared with 92.4% in wild animals and 7.6% in domestic species in 1998). no cases of rabies were reported in human beings in 1 ...	2000	11132881
update: west nile virus activity--eastern united states, 2000.	data reported to cdc through the west nile virus (wnv) surveillance system have shown an increase in the geographic range of wnv activity in 2000 compared with 1999, the first year that wnv was reported in the western hemisphere. in response to this occurrence of wnv, 17 states along the atlantic and gulf coasts, new york city, and the district of columbia conducted wnv surveillance, which included monitoring mosquitoes, sentinel chicken flocks, wild birds, and potentially susceptible mammals (e ...	2000	11105767
particle concentrations in urban microenvironments.	although ambient particulate matter has been associated with a range of health outcomes, the health risks for individuals depend in part on their daily activities. information about particle mass concentrations and size distributions in indoor and outdoor microenvironments can help identify high-risk individuals and the significant contributors to personal exposure. to address these issues in an urban setting, we measured particle count concentrations in four size ranges and particulate matter ( ...	2000	11102296
prevalence of hypogonadism among men with weight loss related to human immunodeficiency virus infection who were receiving highly active antiretroviral therapy.	previous studies have indicated that there is a significant prevalence (50%) of hypogonadism among men with acquired immunodeficiency syndrome (aids)-associated wasting, and for these patients testosterone administration has been shown to increase lean body mass and improve quality of life. however, the prevalence of hypogonadism is not known among men with weight loss related to human immunodeficiency virus (hiv) infection who are receiving highly active antiretroviral therapy (haart). from 199 ...	2000	11073758
further trials stopped by ohrp. office for human research protections.		2000	10973291
predictors of change in the functional status of children with human immunodeficiency virus infection.	the purpose of this study was to identify important clinical predictors of change in the functional status of children with perinatally acquired human immunodeficiency virus (hiv) infection.	2000	10920180