Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| perceptions and opinions regarding human papilloma virus vaccination among young women in malaysia. | the objective of this study is to explore the perceptions and opinions of young women about human papilloma virus (hpv) vaccination and associated barriers. | 2010 | 21338190 |
| prevalence of high-risk human papillomavirus infection and cytologic results in thailand. | cervical cancer is the second most common female cancer with a high mortality rate. the established cause is high-risk types of human papillomavirus (hpv) and a new modality for cervical cancer screening is the combination of cervical cytology with hpv testing. the aim of present study was to identify the prevalence of high-risk hpv infection, and cervical cytological profiles of healthy thai women. this largest cross-sectional investigation of hpv testing so far with cytology screening in thail ... | 2010 | 21338181 |
| koilocytes are enriched for alkaline-labile sites. | this study investigated possible variations in the chromatin structure of koilocytes resulting from human papillomavirus (hpv) infection. alkaline-labile sites (als) were detected with the dna breakage detection–fluorescence in situ hybridization (dbd-fish) technique using a whole human genome dna probe obtained from individuals without koilocytosis. the variable levels of als present were measured quantitatively using image analysis after whole-genome dna hybridization. a significant increase i ... | 2010 | 21337807 |
| cost-consequences evaluation between bivalent and quadrivalent hpv vaccines in italy: the potential impact of different cross-protection profiles. | two human papillomavirus (hpv) vaccines are currently available: a bivalent hpv-16/18 and a quadrivalent hpv-6/11/16/18 vaccine. the vaccines may have different sustained- and cross-protection levels against non-vaccine oncogenic hpv-types. this study investigated the potential difference in clinical and economic impacts provided by two hpv vaccines in italy. | 2011 | 21334734 |
| survivin and telomerase expression in the uterine cervix of women with human papillomavirus-induced lesions. | infection by human papillomavirus is the most important risk factor in the pathogenesis of uterine cervical cancer. the aims of this study were to evaluate the expression of survivin protein and telomerase enzyme in samples of uterine cervix from women with human papillomavirus-induced lesions and to determine the relationship between survivin and telomerase expression and the different grades of cervical squamous intraepithelial neoplasia and invasive cervical carcinoma. | 2011 | 21330827 |
| oral lichen planus: malignant transformation and human papilloma virus: a review of potential clinical implications. | oral lichen planus (olp) occurs in from 2% to 3% of the population and may have a risk of malignant transformation into squamous cell carcinoma (scc). this risk is not necessarily associated with exposure to tobacco and alcohol. an increased awareness of a possible role of human papilloma virus (hpv) and scc led us to review a possible association between this virus infection and malignant transformation of olp. the possible linkage between hpv and the risk of transformation of olp to malignancy ... | 2011 | 21330164 |
| hpv types and variants among cervical cancer tumors in three regions of tunisia. | cervical cancer is the second most common cancer among tunisian women, and the incidence rates vary by region. three tunisian registries report age-standardized rates of 6.3/10(5) in the central region, 5.4/10(5) in the north, and 2.7/10(5) in the south. high-risk human papillomavirus (hpv) types and their variants differ in carcinogenic potential and geographic distribution. the hpv type and variant distribution could be a factor in the differing rates between regions of tunisia. tumor tissue w ... | 2011 | 21328380 |
| casp8 promoter polymorphism is associated with high-risk hpv types and abnormal cytology but not with cervical cancer. | only a small fraction of women infected with human papillomavirus (hpv) progress to cervical cancer pointing to additional risk factors including host genetics that might play a role in development of cervical cancer. caspase-8 (encoded by casp8 gene) is crucial in generating cell death signals to eliminate potentially malignant cells. genetic variation in casp8 might influence the susceptibility to cancer. casp8 -652 6n ins/del polymorphism has been previously reported to influence the progress ... | 2011 | 21328377 |
| prevalence and clinical features of human papillomavirus in head and neck squamous cell carcinoma in okinawa, southern japan. | previous studies from okinawa, a subtropical island in southern japan, demonstrated a higher prevalence of human papillomavirus (hpv) in oral carcinoma and a higher incidence of oral and pharyngeal carcinoma than those for mainland japan. the present study aims to investigate epidemiologic and clinical features of hpv in head and neck squamous cell carcinoma (hnscc) in okinawa. a total of 150 dna samples from 150 okinawan patients with head and neck squamous cell carcinoma (hnscc) were screened ... | 2011 | 21328000 |
| rapid genotyping of human papillomavirus by post-pcr array-based hybridization techniques. | kinetic hybridization measurements on a microarray are expected to become a valuable tool for genotyping applications. a method has been developed that enables kinetic hybridization measurements of pcr products on a low-density microarray. this is accomplished by pumping a solution containing pcr products up and down through a porous microarray substrate. after every pumping cycle, the fluorescently labeled pcr products hybridized to capture probes immobilized on the solid surface of the porous ... | 2011 | 21325552 |
| comparison of hpv genotyping assays and hybrid capture 2 for detection of high-risk hpv in cervical specimens. | high-risk types of human papillomavirus (hr-hpv) are among the primary causes of cervical cancers. hybrid capture 2 (hc-ii) (digene, gaithersburg, md), which detects 13 hr-hpvs as a group, is the only hpv assay approved to date by the united states food and drug administration. in korea, several hpv genotyping assays are commercially available, including hpv rfmp (genematrix co., seoul), hpvdnachip (biomedlab co., seoul), and myhpv chip (mygene co., seoul). we compared the results of these assay ... | 2011 | 21325255 |
| identification of key amino acid residues that determine the ability of high risk hpv16-e7 to dysregulate major histocompatibility complex class i expression. | high risk human papillomavirus (hpv) types are the major causative agents of cervical cancer. reduced expression of major histocompatibility complex class i (mhc i) on hpv-infected cells might be responsible for insufficient t cell response and contribute to hpv-associated malignancy. the viral gene product required for subversion of mhc i synthesis is the e7 oncoprotein. although it has been suggested that high and low risk hpvs diverge in their ability to dysregulate mhc i expression, it is no ... | 2011 | 21321113 |
| the role of human papillomavirus infection in breast cancer. | breast cancer is the leading female cancer and the third most common cause of cancer deaths worldwide. many studies have suggested a possible link between breast cancer pathogenesis and viral infection, particularly mouse mammary tumour virus, simian virus 40, epstein-barr virus, and human papillomavirus (hpv). a significant number of recent studies have reported that approximately 29% of human breast cancer tissues were positive for high-risk hpv subtypes, especially hpv subtypes 16, 18, or 33. ... | 2011 | 21318737 |
| survival and human papillomavirus in oropharynx cancer in tax 324: a subset analysis from an international phase iii trial. | the association between human papillomavirus (hpv) and overall survival (os) in oropharynx cancer (opc) was retrospectively examined in tax 324, a phase iii trial of sequential therapy for locally advanced head and neck cancer. | 2011 | 21317223 |
| biomarker expression in cervical intraepithelial neoplasia: potential progression predictive factors for low-grade lesions. | the aim of this study was to reveal whether 3 biomarkers (p16ink4a, proex c, and human papilloma virus dna) are useful in the diagnosis of cervical intraepithelial neoplasia and whether they could predict disease progression of cervical intraepithelial neoplasia-1. we analyzed 252 cervical specimens: nondysplastic mucosa (n = 9), cervical intraepithelial neoplasia (n = 229), and squamous cell carcinoma (n = 14). immunostaining for p16ink4a and proex c, and the hybridcapture ii assay for human pa ... | 2011 | 21315414 |
| acceptability of human papillomavirus vaccine among the urban, affluent and educated parents of young girls residing in kolkata, eastern india. | aim: the human papillomavirus (hpv) vaccine is recommended for adolescent girls and young women; however, the social structure in india will not permit vaccination of this age-group without parental approval. our study aimed to explore the attitude of affluent, urban indian parents towards the hpv vaccine. methods: well-to-do married couples with at least one daughter between 9-26 years of age were interviewed using a questionnaire in two parts. the first part was to assess their attitude to v ... | 2011 | 21314807 |
| human papillomaviruses prevalence and genital co-infections in hiv-seropositive women in ouagadougou (burkina faso). | the vaginal swabs among hiv-positive women in africa often revealed opportunistic infections such as human papillomavirus (hpv) and mycoplasma that induce respectively cervix cancer and diseases such as vaginosis, abortions, infertility in through salpingitis. the purposes of this study were to: (1) seek for, the prevalence of pathogens such as hpv and mycoplasma; (2) characterize the strains of hpv and estimate their prevalence; (3) identify among these women, those who were co-infected by thes ... | 2010 | 21313918 |
| lack of hpv 16 and 18 detection in serum of colposcopy clinic patients. | persistent infection with high-risk human papillomavirus (hpv) types is necessary for the development of high-grade cervical dysplasia and cervical carcinoma. the presence of hpv dna in the blood of cervical cancer patients has been reported; however, whether hpv dna is detectable in the blood of patients with pre-invasive cervical disease is unclear. | 2011 | 21306941 |
| women's sexual behavior. population-based study among 65,000 women from four nordic countries before introduction of human papillomavirus vaccination. | sexual behavior is of public health interest because of the association with reproductive health and sexually transmitted infections such as human papillomavirus, which is the causal factor of cervical cancer. the aim of the study was to describe patterns in women's sexual behavior in four nordic countries. | 2011 | 21306319 |
| awareness and knowledge about human papillomavirus among latina immigrants. | few studies have examined associations with the public's awareness and knowledge of the human papillomavirus (hpv) among latina immigrants. the primary purpose of this study was to assess hpv awareness and knowledge, while examining demographic and healthcare utilization associations. | 2010 | 21305817 |
| the hpv vaccine: are dosing recommendations being followed? | the aims of this study were to determine the percentage of females who after initiating the human papillomavirus (hpv) vaccine series, both completed it and completed it on-time, as well as to examine factors associated with series completion and on-time completion. using data from the north carolina immunization registry, of 138,823 females analyzed, 55% completed the series, and 28% completed it on-time. over 83% of those who initiated the vaccine series in 2006 completed it by the final study ... | 2011 | 21300098 |
| text message reminders to promote human papillomavirus vaccination. | to implement and evaluate text message reminders for the second (hpv2) and third (hpv3) vaccine doses. | 2011 | 21300094 |
| distribution of hpv genotypes in women with cervical cancer in auckland, new zealand; a review of 50 specimens between 2000-2006. | in new zealand, around two hundred women are diagnosed with cervical cancer annually, with approximately seventy deaths from cervical cancer per year. | 2010 | 21299512 |
| bd-proexc as adjunct molecular marker for improved detection of cin2+ after hpv primary screening. | we investigated the efficacy of 8 cervical cancer screening strategies relative to cytology with emphasis on immunocytochemical detection of high-risk human papillomavirus (hrhpv)-induced cell transformation (bd-proexc) as a tool of triage following primary cytology or hrhpv testing. 3,126 women were tested with bd-surepath liquid-based cytology, hrhpv pcr genotyping and bd-proexc immunostaining, and colposcopy verification to calculate sensitivity and positive predictive value (ppv) in detectin ... | 2011 | 21297040 |
| frequency of human papillomavirus infection, coinfection, and association with different risk factors in colombia. | the aims of this study were to provide new insights into infection patterns of six high-risk human papillomaviruses (hr-hpv-16, -18, -31, -33, -45, and -58) and two low-risk hpv types (lr-hpv-6 and -11), their association with risk factors and coinfection. | 2011 | 21296271 |
| distribution of human papillomavirus load in clinical specimens. | the information about the range and distribution of human papillomavirus load in clinical specimens is important for the design of accurate clinical tests. the amount of human papillomavirus in cervical specimens was estimated using the digene hc2 hpv dna test(®) (qiagen). this semi-quantitative assay is based on linear signal amplification with an analytical limit-of-detection of approximately 2500 virus copies per assay and 3-4 log dynamic range. the dynamic range of the assay was extended by ... | 2011 | 21295613 |
| human papillomavirus infection in women with and without cervical cancer in tbilisi, georgia. | background: no accurate estimates of cervical cancer incidence or mortality currently exist in georgia. nor are there any data on the population-based prevalence of high-risk (hr) human papillomavirus (hpv) infection, which, in the absence of good-quality screening, is known to correlate with cervical cancer incidence. methods: we obtained cervical cell specimens from 1309 women aged 18-59 years from the general population of tbilisi, and also from 91 locally diagnosed invasive cervical cancers ... | 2011 | 21292583 |
| biphasic vesicles for topical delivery of interferon alpha in human volunteers and treatment of patients with human papillomavirus infections. | purpose. topical biphasic vesicle delivery system encapsulating interferon alpha (ifn a) was developed as an alternative to injections used to treat human papillomavirus (hpv) infections. methods. biphasic lipid vesicles encapsulating increasing doses of ifn a (biphasic ifn a) were characterized for encapsulation efficiency, size, zeta potential and vesicle structure by centrifugation, dynamic light scattering, confocal microscopy and small-angle x-ray scattering. biphasic ifn-a delivery into hu ... | 2011 | 21291377 |
| assessment of effectiveness and cost-effectiveness of hpv testing in primary screening for cervical. | the introduction of a screening programme for cervical carcinoma in germany has led to a significant reduction in incidence of the disease. to date, however, diagnosis in germany has been based solely on cervical cytology, which has been criticised because of a low sensitivity and consequently high rate of false negative results. because an infection with the human papillomavirus (hpv) previously was found to be a necessary aetiological factor in the development of cervical cancer, there has bee ... | 2007 | 21289942 |
| decision-analytic modeling to evaluate the long-term effectiveness and cost-effectiveness of hpv-dna testing in primary cervical cancer screening in germany. | persistent infections with high-risk types of human papillomavirus (hpv) are associated with the development of cervical neoplasia. compared to cytology hpv testing is more sensitive in detecting high-grade cervical cancer precursors, but with lower specificity. hpv based primary screening for cervical cancer is currently discussed in germany. decisions should be based on a systematic evaluation of the long-term effectiveness and cost-effectiveness of hpv based primary screening. | 2010 | 21289878 |
| health-related quality of life in indian patients with three viral sexually transmitted infections: herpes simplex virus-2, genital human papilloma virus and hiv. | health-related quality of life (hrqol) has not been studied in indian patients with viral sexually transmitted infections (stis): herpes simplex virus-2 (hsv-2) and genital human papilloma virus (hpv) infections. furthermore, there is no reported study that compares hrqol among these two viral stis and hiv. | 2011 | 21289022 |
| safety of the hpv bivalent and quadrivalent vaccines during pregnancy (february). | objective: to evaluate the safety of the human papillomavirus (hpv) bivalent and quadrivalent vaccines in pregnancy. data sources: pubmed (1966-august 2010) was searched using the terms human papillomavirus, human papillomavirus vaccine, and pregnancy. references were reviewed for relevant information. study selection and data extraction: all studies including humans that were published in english with data describing hpv vaccine administration in pregnancy were evaluated. data synthesis: two co ... | 2011 | 21285408 |
| prevalence of human papillomavirus genotypes in cytologic abnormalities from unvaccinated women living in north-western spain. | cervical cancer and its precursors low-grade squamous intraepithelial lesions (lsil) and high-grade squamous intraepithelial lesions (hsil) are associated with infection by human papillomavirus (hpv), in particular hpv 16 and 18. the distribution of the hpv genotype varies with the severity of cervical disease, age and the geographic location of the patients. we report the results of a population study carried out in a region of north-western (nw) spain aimed at determining the prevalence of sin ... | 2011 | 21284738 |
| what is your diagnosis? bowenoid papulosis. | 2010 | 21284277 | |
| considerations for human papillomavirus (hpv) vaccination of mid-adult women in the united states. | in the united states, human papillomavirus (hpv) vaccination is recommended for 11 or 12 year old girls, with catch-up vaccination through age 26 years. data are available for women over the age of 26 years on immunogenicity for both quadrivalent and bivalent hpv vaccines and on efficacy for the quadrivalent hpv vaccine. if hpv vaccines are licensed for use in women over 26 years of age (mid-adult women), recommendations for this age group will need to be considered. this review summarizes vacci ... | 2011 | 21277406 |
| intradermal injection of ppd as a novel approach of immunotherapy in anogenital warts in pregnant women. | immunotherapy for treatment of recalcitrant warts was used through different modalities including intralesional injection of purified protein derivative (ppd), which is an extract of mycobacterium tuberculosis, used for testing exposure to tuberculin protein, either from a previous vaccination or from the environment. this method is used to evaluate the efficacy of a new approach of intradermal injection of ppd in the treatment of anogenital warts in pregnant women. a total of 40 pregnant women, ... | 2011 | 21276168 |
| automated high throughput dna isolation for detection of human papillomavirus in oral rinse samples. | oral hpv infection elevates risk of oropharyngeal cancer, but its natural history is unknown. natural history studies necessitate validation of an automated, high-throughput method for hpv genomic dna detection in oral rinse samples (ors). | 2011 | 21273118 |
| comparison of the diagcor genoflow human papillomavirus array test and roche linear array hpv genotyping test. | persistent infection of high-risk (hr) human papillomavirus (hpv) infection has been widely associated with cervical cancer. monitoring hpv infection is therefore an important step against cervical cancer development. the diagcor genoflow human papillomavirus array test (genoflow) is a novel hpv test based on pcr and "flow-through" hybridization that can identify 33 hpv subtypes in 3 hours. in the present study, the genoflow test was evaluated by comparing the genotyping results of 100 samples w ... | 2010 | 21270940 |
| clinicopathologic implications of the epidermal growth factor receptor, cyclooxygenase 2 expression, and human papillomavirus status in squamous cell carcinoma of the uterine cervix in the elderly. | to find information on invasive squamous cervical carcinoma in the elderly, 110 invasive squamous cervical carcinomas obtained from 2 groups of patients (aged <60 and >60 years) were analyzed for human papillomavirus (hpv) status by polymerase chain reaction study, for immunohistochemical epidermal growth factor receptor (egfr), cyclooxygenase 2 (cox-2) expression, and clinicopathologic features. | 2011 | 21270615 |
| phylogeny and polymorphism in the long control region, e6, and l1 of human papillomavirus types 53, 56, and 66 in central brazil. | several studies related that different human papillomavirus (hpv) types and intratype variants can present different oncogenic potential. in opposite to hpvs 16 and 18 variants, information about variants of other carcinogenic hpv types is still scarce. the aim of this study was to investigate the genetic variability of hpvs 53, 56, and 66 from central brazil isolates. | 2011 | 21270605 |
| mutants of plant genes for developing cancer vaccines. | preventive human papillomavirus (hpv) vaccination is an expensive practice and it may be an insufficient tool to tackle cervical cancer worldwide. therapeutic intervention is seeking for safe/effective vaccines inducing the activation of cd8+ cytotoxic t lymphocytes (ctls) that is required to clear the tumor. linking a tumor-specific antigen (i.e. the e7 oncoprotein of the 'high risk' hpvs) to molecules able to increase its immune 'visibility' represents a strategy to force the immune system to ... | 2011 | 21266841 |
| expression of human papillomavirus 16 e7ggg oncoprotein on n- and c-terminus of potato virus x coat protein in bacterial and plant cells. | the e7 oncoprotein from human papillomavirus type 16 (hpv16) is an attractive candidate for anti-cancer therapeutical vaccine development. in this study, we engineered different fusions of mutagenized coding sequence of e7 oncoprotein (e7ggg) with coat protein of potato virus x (pvx cp) both on 5'- and 3'-terminus of pvx cp and evaluated the influence of the length of linker (no linker, 4, 15aa) connecting pvx cp and e7ggg on their production. at first the expression in escherichia coli was cond ... | 2011 | 21266198 |
| prevalence of human papillomavirus among women with normal cervical cytology in kuwait. | this study was undertaken to determine the prevalence and type specific distribution of human papillomavirus (hpv) in women with normal cervical cytology in kuwait. the study is the first of its type in kuwait and one of few in the middle east. the age specific distribution of hpv types was determined in 3,011 thinprep samples taken from women seeking routine gynaecological care. thinprep samples were screened for hpv dna by real-time pcr. the type specific distribution of the viruses was determ ... | 2011 | 21264866 |
| correlates of receiving recommended adolescent vaccines among adolescent females in north carolina. | immunization is a successful and cost-effective method for preventing disease, yet many adolescents do not receive recommended vaccines. we assessed correlates of uptake of three vaccines (tetanus booster, meningococcal, and human papillomavirus [hpv] vaccines) recommended for adolescent females. methods. we examined cross-sectional data from 647 parents of 11-20 year-old females from north carolina who completed the carolina hpv immunization measurement and evaluation (chime) project follow-up ... | 2011 | 21263224 |
| stepwise algorithm combining hpv high-risk dna-based assays and rna-based assay for high grade cin in women with abnormal smears referred to colposcopy. | the detection of high-risk human papillomavirus (hpv) dna provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (cin). | 2010 | 21263189 |
| is human papillomavirus screening preferable to current policies in vaccinated and unvaccinated women? a cost-effectiveness analysis. | italy was the first european nation to offer free vaccination against human papillomavirus (hpv) types 16 and 18. the vaccination is actively encouraged and is available free of charge to 11-year-old girls. the introduction of new technologies such as hpv dna testing and hpv vaccination requires cost-effectiveness analysis of cervical cancer strategies in italy for both vaccinated and unvaccinated women. | 2010 | 21258128 |
| estimating the impact of human papillomavirus (hpv) vaccination on hpv prevalence and cervical cancer incidence in mali. | human papillomavirus vaccines have potential to reduce cervical cancer incidence and mortality; however, cultural and economic barriers may hinder success in developing countries. we assessed impact of a single vaccine campaign in mali with use of mathematical modeling. our model shows that decreases in the prevalence of human papillomavirus infection are proportional to achieved vaccination coverage. | 2011 | 21252142 |
| cd40 is overexpressed by hpv16/18-e6 positive cervical carcinoma and correlated with clinical parameters and vascular density. | cd40 is expressed in many tumor cells, however, its role in tumor biology is yet to be demonstrated. in the present study, we investigated the role of cd40 in cervical carcinoma. in vivo, we evaluated cd40 expression in 56 cervical carcinoma tissues, 43 cervicitis and 38 normal cervix, and investigated the relationship between cd40 and hpv antigen, histopathological parameters, vascular density, and vascular endothelial growth factor (vegf) expressions. the results clearly demonstrated that cd40 ... | 2011 | 21251894 |
| prevalence and type distribution of human papillomavirus in healthy japanese women aged 20 to 25 years old enrolled in a clinical study. | efficacy, immunogenicity and tolerability of the human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine were evaluated in japanese women aged 20-25 years, for which results have been reported previously. we analyzed the baseline data from that study and report the prevalence rates of hpv infection in young healthy japanese women. one thousand and the forty japanese women aged 20-25 years were enrolled in a phase ii, double-blind, controlled, randomized, multicenter study. at study entry, cervi ... | 2011 | 21251162 |
| human papilloma virus infections. | genital warts are believed to be caused by human papilloma viruses and to be sexually transmitted. the viruses are classified by dna types, which appear to cause different types of disease. the choice of treatment, and usually its success rate, vary according to the type of disease and its location. | 1989 | 21248973 |
| development of a cellular assay system to study the genome replication of high- and low-risk mucosal and cutaneous human papillomaviruses. | we found that recircularized high-risk (type 16 and 18) and low-risk mucosal (type 6b and 11) and cutaneous (type 5 and 8) human papillomavirus (hpv) genomes replicate readily when delivered into u2os cells by electroporation. the replication efficiency is dependent on the amount of input hpv dna and can be followed for more than 3 weeks in proliferating cell culture without selection. cotransfection of recircularized hpv genomes with a linear g418 resistance marker plasmid has allowed subclonin ... | 2011 | 21248030 |
| detection of human papillomavirus in multiple eccrine poromas in a patient with chronic graft-vs-host disease and immunosuppression. | 2011 | 21242407 | |
| single-tube multiplex pcr using type-specific e6/e7 primers and capillary electrophoresis genotypes 21 human papillomaviruses in neoplasia. | 2011 | 21241508 | |
| retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the e7 oncoprotein in hpv 16-positive cells. | "high risk" human papillomavirus strains are the causative agents of the vast majority of carcinomas of the uterine cervix. in these tumors, the physical integration of the hpv genome is a frequent, though not invariable occurrence, but the constitutive expression of the e6 and e7 viral genes is always observed, suggesting key roles for the e6 and e7 oncoproteins in the process of malignant transformation. the "intracellular antibody" technology using recombinant antibodies in single-chain forma ... | 2011 | 21241471 |
| human papillomavirus and predictors of cervical intraepithelial neoplasia among young mothers in a prospective follow-up study. | to study the incidence times and rates for cervical intraepithelial neoplasia (cin) and its predictors. | 2010 | 21241262 |
| molecular pathogenesis of cervical cancer. | cervical cancer is a sexually transmitted disease that results from infection with oncogenic types of human papillomavirus (hpv). oncogenic hpv dna is found in over 95% of invasive cervical cancers worldwide. cervical cancer is a leading cause of cancer deaths in developing countries because of high hpv infection rates and lack of comprehensive cervical pap smear testing of susceptible women. vaccination against hpv prevents the acquisition of cervical dysplastic lesions among eligible women who ... | 2011 | 21239888 |
| diagnosis of anal human papillomavirus infection: polymerase chain reaction or cytology? | to investigate the relationship between human immunodeficiency virus (hiv)-positive and hiv-negative patients engaging in promiscuous behaviors and anal human papillomavirus (hpv) infection diagnosed by polymerase chain reaction (pcr) and cytology. | 2011 | 21239202 |
| a human papillomavirus 8 e7 protein produced in plants is able to trigger the mouse immune system and delay the development of skin lesions. | we investigated the potential of nicotiana benthamiana to express the e7 protein of human papillomavirus 8 (hpv-8), a paradigm genotype among cutaneous hpvs. the protein, modified in its putative prb-binding domain (e7(qgd)), was transiently expressed in leaves following infiltration with agrobacteria carrying either a binary vector combined with silencing suppressor constructs or replicating tobacco mosaic virus (tmv)-based vectors with different targeting signals. hpv-8 e7(qgd) yields ranged f ... | 2011 | 21234770 |
| high-risk hpv dna status and p16 (ink4a) expression as prognostic markers in patients with squamous cell cancer of oral cavity and oropharynx. | to determine and compare the influence of the hpv dna status and p16(ink4a) expression on the outcome of postoperative radiotherapy for squamous cell cancer of the oral cavity or oropharynx. | 2010 | 21225495 |
| identification of differential expressed transcripts in cervical cancer of mexican patients. | the aim of this study was to identify the gene expression profile in biopsies of patients with cervical intraepithelial neoplasia (cin) 1, cin 2, cin 3, and microinvasive cancer by suppression subtractive hybridization and southern blotting. after analyzing 1,800 cdna clones, we found 198 upregulated genes, 166 downregulated, and no significant change of gene expression in 86 clones (p = 0.005). these results were validated by northern blot analysis (p = 0.0001) in the identification of 28 overe ... | 2011 | 21225484 |
| molecular characterization of late stomal recurrence following total laryngectomy. | the goal was to determine recurrent or second primary status for late stomal malignancies, 16 and 17 years post-total laryngectomy in two laryngeal squamous cell carcinoma (lscc) patients, based on dna methylation signatures and hpv typing. adopting a literature review based definition of late stomal recurrences as new primaries at the site of the stoma or neopharynx occurring >5 years after total laryngectomy, we employed a multi-gene candidate approach to examine promoter methylation in 24 tum ... | 2011 | 21225233 |
| population-based frequency assessment of hpv-induced lesions in patients with borderline pap tests in the emilia-romagna region: the pater study. | the pater study assessed the frequency of high-risk (hr) and low-risk (lr) human papillomavirus (hpv) in hpv-induced lesions in patients with borderline cytology. | 2011 | 21222568 |
| recurrent laryngeal papillomatosis: successful treatment with human papillomavirus vaccination. | the authors describe the case of a 5-year-old girl with recurrent laryngeal papillomatosis (rlp) due to human papillomavirus (hpv) type 11, who required frequent surgical treatment. complete recovery occurred after hpv vaccination (gardasil). confirmed remission of rlp has continued during the 17 months of follow-up since vaccination. the authors conclude that hpv vaccination may represent a new therapeutic option in this situation. | 2011 | 21220258 |
| [prevalence and determinants of lower reproductive tract infections among women aged 25 - 54 years in beijing.] | objective: to determine the prevalence and determinants of the most commonly seen lower reproductive tract infections among women aged 25 - 54 years in beijing. methods: the study population consisted of 6339 women aged 25 - 54 years in 137 communities of beijing. focus of this study was to understand the prevalence of the following diseases as:bacterial vaginosis, trichomoniasis and vulvovaginal candidiasis. in addition to their prevalence rates, a generalized equation for estimation was used t ... | 2010 | 21215070 |
| management of pre-invasive cervical cancer in low-resource setting. | cervical cancer is one of the health burdens in many developing countries. the advanced knowledge in the past decade reassured the important role of human papillomavirus as the necessary cause of cervical cancer and makes a clear understanding of its natural history. cervical cancer has a long period of pre-invasive stage, and only a small proportion of cervical intraepithelial neoplasia (cin) that can progress to be an invasive lesion. appropriate management of cin can prevent invasive cervical ... | 2004 | 21213526 |
| evidence of human papillomavirus in the placenta. | human papillomavirus (hpv) is an epitheliotropic virus typically infecting keratinocytes but also possibly epithelial trophoblastic placental cells. in the present study, we set out to investigate whether hpv can be recovered from transabdominally obtained placental cells to avoid any confounding contamination by hpv-infected cervical cells. thirty-five placental samples from women undergoing transabdominal chorionic villous sampling were analyzed, and we detected hpv-16 and hpv-62 in 2 placenta ... | 2010 | 21208925 |
| the influence of multiple human papillomavirus types on the risk of genotype-concordant incident infections of the anus and cervix: the hawaii hpv cohort study. | the influence of multiple human papillomavirus (hpv) types on detection of concordant incident hpv infections of the cervix or anus following infection at the other anatomic site was examined in a cohort of 897 women. multiple hpv infections at the anus were not significantly associated with subsequent acquisition of a concordant cervical infection, whereas prior coinfections in the cervix increased risk of a new cervical hpv infection. incident anal hpv infections following concordant cervical ... | 2010 | 21208924 |
| long-term persistence of human papillomavirus in environments. | the possibility of its indirect transmission of human papillomavirus (hpv) via formites has been widely raised but with no biological proof. this study explored the durability of hpv16 pseudoviruses and native viruses in different environmental contamination scenarios. | 2011 | 21208649 |
| human papillomavirus in brazilian women with and without cervical lesions. | human papillomavirus (hpv) high-risk (hr) types are the causal factor for cervical cancer and premalignant dysplasia. data on frequency of hpv types provide a basis to design and evaluate hpv prevention programs. taking into account the heterogeneity of hpv types across and within populations this study aims to access the hpv frequency in brazilian women. | 2011 | 21208414 |
| preclinical development of highly effective and safe dna vaccines directed against hpv 16 e6 and e7. | to allow vaccination irrespective of hla type, dna vaccines encoding full-length antigens are required. however, here, we demonstrate that the immunogenicity of dna vaccines encoding the full-length human papillomavirus (hpv) type 16 e7 and e6 proteins is highly reduced compared to vaccines encoding only the immunodominant epitope. furthermore, the low remaining immunogenicity is essentially lost for both e7 and e6 when a nononcogenic "gene-shuffled" variant is utilized. to address these issues, ... | 2011 | 21207427 |
| quadrivalent human papillomavirus (hpv) vaccine: a review of safety, efficacy, and pharmacoeconomics. | what is known and background: the introduction of vaccines has lead to a significant reduction in morbidity and mortality from diseases such as measles, rubella and poliomyelitis, as well as the eradication of smallpox (ertl hc, xiang z (1996) the journal of immunology, 156, 3579-3582). a recent vaccine approved by the food and drug administration (fda) is the recombinant quadrivalent human papillomavirus (hpv) vaccine (merck, gardasil®). concerns raised with this preventive measure include safe ... | 2011 | 21198715 |
| regulation of immune responses to hpv infection and during hpv-directed immunotherapy. | the recent development of vaccines prophylactic against human papillomavirus (hpv) infection has the potential to reduce the incidence of cervical cancer globally by up to 70% over the next 40 years, if universal immunization is adopted. as these prophylactic vaccines do not alter the natural history of established hpv infection, immunotherapies to treat persistent hpv infection and associated precancers would be of benefit to assist with cervical cancer control. efforts to develop immuno-therap ... | 2011 | 21198666 |
| can self vaginal douching for high risk hpv screening replace or assist efficacy of cervical cancer screening? | to study the accuracy of self vaginal douching and collection for hpv types 16, 18, 31 and 33 in women visiting thammasat hospital for the explicit purpose of cervical screening. | 2010 | 21198300 |
| human papillomavirus infection in honduran women with cervical intraepithelial neoplasia or cervical cancer. | the aims of this study were to investigate human papillomavirus (hpv) genotypes in women with cervical intraepithelial lesions and cervical cancer (cc) in honduras and to identify epidemiological cofactors that contribute to the development of cc. | 2011 | 21192177 |
| performance of the aptima high-risk human papillomavirus mrna assay in a referral population in comparison with hybrid capture 2 and cytology. | this study compared the aptima human papillomavirus (hpv) (ahpv; gen-probe incorporated) assay, which detects e6/e7 mrna from 14 high-risk types, the hybrid capture 2 hpv dna (hc2; qiagen incorporated) test, and repeat cytology for their ability to detect high-grade cervical lesions (cervical intraepithelial neoplasia grade 2+ [cin2+]) in women referred to colposcopy due to an abnormal papanicolaou (pap) smear. a total of 424 clinical specimens, stored in liquid-based cytology (lbc) vials at roo ... | 2010 | 21191046 |
| hpv prophylactic vaccination: the first years and what to expect from now. | new prophylactic hpv vaccines have the power to prevent many hpv infections, thus reducing the burden of hpv-associated diseases. two vaccines composed of hpv l1 proteins self assembled into virus-like particles (vlps) have been developed: one containing vlps of hpv types 6, 11, 16 and 18, while the other vaccine is composed of hpv 16 and 18 vlps. large phase ii and iii clinical trials to assess prophylactic efficacy have been conducted in which both hpv infection endpoints and disease endpoints ... | 2010 | 21190794 |
| long-term persistence of systemic and mucosal immune response to hpv-16/18 as04-adjuvanted vaccine in preteen/adolescent girls and young women. | vaccination against oncogenic human papillomavirus (hpv) types is one key intervention for cervical cancer prevention. this follow-up study assessed the persistence of the systemic and mucosal immune responses together with the safety profile of the hpv-16/18 as04-adjuvanted vaccine administered to young women aged 10-25 years. serum and cervicovaginal secretion (cvs) samples were collected at pre-specified time-points during the 48-month follow-up period. anti-hpv-16/18 antibody levels in serum ... | 2010 | 21190190 |
| two distinct pathways to development of squamous cell carcinoma of the vulva. | squamous cell carcinoma (scc) accounts for approximately 95% of the malignant tumors of the vaginal vulva and is mostly found in elderly women. the future numbers of patients with vulvar scc is expected to rise, mainly because of the proportional increase in the average age of the general population. two different pathways for vulvar scc have been put forth. the first pathway is triggered by infection with a high-risk-type human papillomavirus (hpv). integration of the hpv dna into the host geno ... | 2010 | 21188235 |
| [the treatment research of people with different types of hpv infection in sterile patients]. | explore the optimal treatment of infertility patients infected with different types of human papillomavirus (hpv). | 2010 | 21186535 |
| detection of human papillomavirus in bronchoalveolar lavage samples in immunocompetent children. | human papillomavirus (hpv) has been detected in lungs of adults and has been proposed to play a role in lung carcinogenesis. however, no data are currently available on the incidence of hpv in the lower respiratory tract of children. | 2011 | 21178656 |
| [analysis of high risk factors associated with cervical intraepithelial neoplasia in married women aged 25 - 54 years in beijing between 2007 - 2008]. | to investigate high risk factors associated with cervical intraepithelial neoplasia (cin) in married women aged 25 to 54 years in beijing. | 2010 | 21176557 |
| awareness and knowledge of hpv, cervical cancer, and vaccines in young women after first delivery in são paulo, brazil--a cross-sectional study. | the success of hpv vaccination programs will require awareness regarding hpv associated diseases and the benefits of hpv vaccination for the general population. the aim of this study was to assess the level of awareness and knowledge of human papillomavirus (hpv) infection, cervical cancer prevention, vaccines, and factors associated with hpv awareness among young women after birth of the first child. | 2010 | 21176230 |
| variation of human papillomavirus 16 in cervical and lung cancers in sichuan, china. | although the crucial role of human papillomaviruses (hpvs), especially hpv-16 in various cancers has been confirmed, the variation of hpv-16 among different cancers have not been investigated in a specific geographic location. in order to elucidate whether similar hpv-16 variants are involved in different kinds of cancers in the same geographic location, the analysis of sequence variants of e6 and e7 oncogenes and l1 gene of hpv-16 in cervical and lung cancers in sichuan, china, was carried out. ... | 2010 | 21175246 |
| maldi imaging as a specific diagnostic tool for routine cervical cytology specimens. | cervical squamous cell carcinoma (scc) is among the most common malignancies in women worldwide. in developed countries routine cytology screening has dramatically reduced scc mortality within the last three decades. high risk (hr) human papilloma virus (hpv) infection is the main causal factor in nearly 100% of invasive sccs, in most cases of low grade squamous intraepithelial lesion (lsil) and in nearly all cases of high grade squamous intraepithelial lesion (hsil). detection of hr-hpv dna has ... | 2010 | 21174066 |
| correlation of cellular immunity with human papillomavirus 16 status and outcome in patients with advanced oropharyngeal cancer. | to determine whether the favorable outcome associated with human papillomavirus (hpv) 16-positive oropharyngeal cancer is related to a patient's adaptive immunity. | 2010 | 21173378 |
| [prevalence of human papillomavirus in the pubic hair follicles of healthy men and male patients with genital warts]. | human papillomavirus (hpv) commonly exists in healthy individuals, but its prevalence in the pubic hair follicles is not yet clear, nor is the relationship between hpv infection in the pubic hair follicles and the recurrence of genital warts in men. this study aimed to investigate hpv infection in the pubic hair follicles of healthy men and patients with genital warts, and to look into the correlation of hpv infection with recurrent genital warts. | 2010 | 21171259 |
| association of human papillomavirus-related knowledge, attitudes, and beliefs with hiv status: a national study of gay men. | anal cancer and other diseases caused by human papillomavirus (hpv) are more common among people who are hiv-positive. to understand the potential role of hiv status in hpv prevention efforts, we examined hpv-related knowledge, attitudes, and beliefs among hiv-positive and hiv-negative gay men. | 2011 | 21169868 |
| procedural and temporal compliance to cervical cancer screening guidelines in a cdc-funded program in alaska. | to estimate changes in clinical practice in a cervical cancer screening program after the american society for colposcopy and cervical pathology's issuance of 2006 consensus guidelines (2006cg) for managing abnormal pap tests. | 2011 | 21169865 |
| human papillomavirus is detectable in barrett's esophagus and esophageal carcinoma but is unlikely to be of any etiologic significance. | barrett's esophagus (be), a known precursor of esophageal adenocarcinoma has recently been associated with human papillomavirus (hpv). p16(ink4a) expression is a recognized surrogate marker of hpv infection in the cervix. | 2010 | 21169053 |
| vaccine generated immunity targets an hpv16 e7 hla-a2.1-restricted cd8(+) t cell epitope relocated to an early gene or a late gene of the cottontail rabbit papillomavirus (crpv) genome in hla-a2.1 transgenic rabbits. | the newly established hla-a2.1 transgenic rabbit model has proven useful for testing the immunogenicity of well known and computer-predicted a2-restricted epitopes. in the current study we compared the protective immunity induced to a preferred hpv16 e7 a2-restricted epitope that has been relocated to positions within the crpv e7 gene and the crpv l2 gene. epitope expression from both the e7 protein and the l2 protein resulted in increased protection against viral dna challenge of the hla-a2.1 t ... | 2010 | 21167863 |
| increased plasma levels of adipokines and inflammatory markers in older women with persistent hpv infection. | we observed diminished lymphoproliferation to multiple stimuli in older women with persistent cervical human papillomavirus (hpv) infection. adipokines are a class of inflammatory cytokines that are altered in some persistent infections. the objective was to compare the level of adipokines and inflammatory cytokines in heparinized plasma from women with persistent hpv cervical infection (cases, n=50, oversampled for their weak lymphoproliferation responses) with women with no evidence of persist ... | 2010 | 21167737 |
| the molecular biology of head and neck cancer. | head and neck squamous cell carcinomas (hnsccs) are caused by tobacco and alcohol consumption and by infection with high-risk types of human papillomavirus (hpv). tumours often develop within preneoplastic fields of genetically altered cells. the persistence of these fields after treatment presents a major challenge, because it might lead to local recurrences and second primary tumours that are responsible for a large proportion of deaths. aberrant signalling pathways have been identified in hns ... | 2010 | 21160525 |
| human papillomavirus vaccine: now for boys too? | 2011 | 21157346 | |
| computer-aided analysis of structural properties and epitopes of iranian hpv-16 e7 oncoprotein. | infection by human papillomavirus type 16 (hpv-16) is the cause of 50% or more of cervical cancers in women. the e7 oncoprotein of hpv-16 has long been known as a potent immortalizing and transforming agent. we used different servers like pseaac, mhc_binding, mhc_ii_binding and expasy for the present computational prediction. the results for t cell epitopes showed that b1501, a0203, a0201, a0202, a6801 and drb0405 alleles had lower ic50 than other alleles. we also predicted several peptides with ... | 2010 | 21153780 |
| prevalence and determinants of high-risk human papillomavirus infection in women from a sub-saharan african community. | background:: human papillomavirus infection with high-risk types (hr-hpv) is a necessary cause of cervical cancer, the most common malignancy among sub-saharan african women. little is known about prevalence of cervical hr-hpv infection in this region. methods:: a cross-sectional study of 1528 women examined the determinants of hr-hpv infection among women in kinshasa, democratic republic of congo. information was collected on sociodemographic, reproductive, lifestyle characteristics, and health ... | 2010 | 21150817 |
| human papillomavirus e7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases. | infection by human papillomaviruses (hpv) leads to the formation of benign lesions, warts, and in some cases, cervical cancer. the formation of these lesions is dependent upon increased expression of proangiogenic factors. angiogenesis is linked to tissue hypoxia through the activity of the oxygen-sensitive hypoxia-inducible factor 1α (hif-1α). our studies indicate that the hpv e7 protein enhances hif-1 transcriptional activity whereas e6 functions to counteract the repressive effects of p53. bo ... | 2010 | 21148070 |
| aptima hpv e6/e7 mrna test is as sensitive as hybrid capture 2 assay but more specific at detecting cervical precancer and cancer. | detection of human papillomavirus (hpv) e6/e7 oncogene expression may be more predictive of cervical cancer risk than testing for hpv dna. the aptima hpv test (gen-probe) detects e6/e7 mrna of 14 oncogenic types. its clinical performance was compared with that of the hybrid capture 2 dna test (hc2; qiagen) in women referred for colposcopy and those routinely screened. aptima was also compared with the pretect hpv-proofer e6/e7 mrna assay (proofer; norchip) in the referral population. cervical sp ... | 2010 | 21147950 |
| introduction of hematoxylin as an electroactive label for dna biosensors and its employment in detection of target dna sequence and single-base mismatch in human papilloma virus corresponding to oligonucleotide. | for the detection of dna hybridization, a new electrochemical biosensor was developed on the basis of the interaction of hematoxylin with 20-mer deoxyoligonucleotides (from human papilloma virus, hpv). the study was performed based on the interaction of hematoxylin with an alkanethiol dna probe self-assembled gold electrode (ss-dna/aue) and its hybridization form (ds-dna/aue). the optimum conditions were found for the immobilization of hpv probe on the gold electrode (aue) surface and its hybrid ... | 2010 | 21146975 |
| vaccination against human papillomavirus types 16 and 18: the impact on cervical cancer. | 2010 | 21142854 | |
| integrating novel primary- and secondary-prevention strategies: the next challenge for cervical cancer control. | the advent of prophylactic vaccines against human papillomavirus (hpv) infection, the cause of cervical cancer, and of new molecular methods to screen for this disease have become key developments in cancer control in the last 5 years. although pap cytology has had a significant history as a key method for cervical cancer screening, not all countries have benefited from this technology or have been able to implement the necessary public health steps to manage and treat the precancerous lesions t ... | 2010 | 21142659 |