Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| viral immunoreceptor tyrosine-based activation motif (itam)-mediated signaling in cell transformation and cancer. | viruses frequently co-opt host cell pathways to enhance their propagation or to enable latent infection. certain receptors expressed by hematopoietic cells have immunoreceptor tyrosine-based activation motifs (itams) in their cytoplasmic domains that initiate cellular activation, proliferation and differentiation. some viruses have evolved, or acquired from their host, genes that encode itam-bearing proteins. these itam-bearing viral proteins have been implicated in cellular transformation in vi ... | 2006 | 16815013 |
| dna viruses in human cancer: an integrated overview on fundamental mechanisms of viral carcinogenesis. | the first experimental data suggesting that neoplasm development in animals might be influenced by infectious agents were published in the early 1900s. however, conclusive evidence that dna viruses play a role in the pathogenesis of some human cancers only emerged in the 1950s, when epstein-barr virus (ebv) was discovered within burkitt lymphoma cells. besides ebv, other dna viruses consistently associated with human cancers are the hepatitis b virus (hbv), human papillomavirus (hpv), and kaposi ... | 2007 | 16814460 |
| genetic organization and hypoxic activation of the kaposi's sarcoma-associated herpesvirus orf34-37 gene cluster. | kaposi's sarcoma-associated herpesvirus (kshv) is the etiologic agent for kaposi's sarcoma (ks) and primary effusion lymphoma (pel). we previously reported that hypoxia activates kshv lytic replication and that the promoter for open reading frame 34 (orf34) contains a functional hypoxia-responsive element (hre). orf34 is part of a cluster of lytic genes (orf34-37) that includes orf36, a phosphotransferase, and orf37, a shutoff exonuclease. rapid amplification of cdna ends analysis revealed that ... | 2006 | 16809309 |
| molecular epidemiology of the hhv-8 k1 gene from moroccan patients with kaposi's sarcoma. | the genetic variability of the human herpesvirus 8 (hhv-8) strains circulating in the populations living in the maghreb region, an endemic area for hhv-8 and associated kaposi's sarcoma, remains largely unknown. we have thus analyzed the genetic variation of the complete k1 gene of hhv-8 in a series of 35 viral strains, originating from 28 moroccan patients with classic, aids-associated or iatrogenic kaposi's sarcoma lesions. all but one of the 35 strains belonged to the large c molecular subtyp ... | 2006 | 16793109 |
| murine gammaherpesvirus (mhv) mk3 gene sequence diversity among 72, 4556, and 68 strains. | murid herpesvirus 4 (muhv-4) currently serves as a model for study of human gamma-herpesvirus pathogenesis. it codes for mk3 protein that similarly as k5 protein of kaposi's sarcoma-associated herpesvirus are members of a family of structurally related viral immune evasion molecules possessing ring-ch finger domain with ubiquitin ligase activity. murine herpesvirus 72 (mhv-72) isolated from the same species of free-living small rodent is considered as closely related to murine herpesvirus 68 (mh ... | 2006 | 16791419 |
| human herpesvirus 8 oral shedding in hiv-infected men with and without kaposi sarcoma. | two main routes of human herpesvirus 8 (hhv-8) transmission are known: sexual, predominantly in men who have sex with men; and nonsexual, in endemic populations. both routes implicate saliva, so identifying the factors that influence oral hhv-8 shedding is important. | 2006 | 16791117 |
| molecular interactions between porcine and human gammaherpesviruses: implications for xenografts? | reactivation of latent herpesviruses is an important cause of morbidity and mortality in human transplantation. this issue might be further complicated in the case of xenotransplantation. zoonotic viruses could reactivate and replicate in the transplanted tissue, and interactions with homologous human viruses could take place. since the pig is a favoured animal as donor of organs for human transplants, we analysed the possibility of interactions between porcine and human herpesviruses. porcine l ... | 2006 | 16768724 |
| kaposi's sarcoma-associated herpesvirus immune modulation: an overview. | kaposi's sarcoma-associated herpesvirus (kshv) is the most recently discovered human herpesvirus. it is the aetiological agent of kaposi's sarcoma (ks), a tumour frequently affecting aids patients not receiving treatment. kshv is also a likely cause of two lymphoproliferative diseases: multicentric castleman's disease and primary effusion lymphoma. the study of kshv offers exciting challenges for understanding the mechanisms of virus pathogenesis, including those involved in establishing infecti ... | 2006 | 16760382 |
| primary mediastinal large b-cell lymphoma: a single-center study of clinicopathologic characteristics. | primary mediastinal large b-cell lymphoma (pmlbcl) is a subset of lbcl with unique clinicopathologic features. some studies have raised the question of differences in biological features and clinical course among patients from different parts of the world. we conducted a retrospective clinicopathologic analysis of 24 patients with pmlbcl from a single center in croatia. we also conducted the first investigation of the frequency of lymphotropic viruses human herpesvirus 6 (hhv-6) and hhv-8 in lym ... | 2006 | 16757434 |
| effusion and solid lymphomas have distinctive gene and protein expression profiles in an animal model of primary effusion lymphoma. | lymphoma usually forms solid tumours in patients, and high expression levels of adhesion molecules are observed in these tumours. however, kaposi's sarcoma-associated herpesvirus (kshv)-related primary effusion lymphoma (pel) does not form solid tumours and adhesion molecule expression is suppressed in the cells. inoculation of a kshv-associated pel cell line into the peritoneal cavity of severe combined immunodeficiency mice resulted in the formation of effusion and solid lymphomas in the perit ... | 2006 | 16741895 |
| big endothelin-1 and interleukin-6 modulation in human microvascular endothelial cells after human herpesvirus 8 infection. | endothelin (et)-1 is an angiogenic factor that, among others, is secreted by endothelial cells during development of several neoplasias. in particular, kaposi sarcoma (ks) skin lesions show overexpression of the et-1 system. spindle cells, which characterize tumor lesions, are of endothelial origin and during disease are infected by human herpesvirus 8 (hhv-8). the majority of these cells are latently infected, suggesting that latent genes are sufficient for maintenance of viral infection and de ... | 2006 | 16741071 |
| notch and wnt signaling: mimicry and manipulation by gamma herpesviruses. | a small number of fundamental cell signaling pathways are key to the regulation of proliferation and differentiation responses during normal development. two of these pathways, the notch and wnt pathways, have proven to be attractive targets for virus interaction and manipulation. in general, viral gene expression and replication are intimately linked to the differentiation state of the infected cell and, in the case of the gamma herpesviruses, establishment of a lifelong persistent infection in ... | 2006 | 16705130 |
| angiosarcoma arising in a lymphedematous abdominal pannus with histologic features reminiscent of kaposi's sarcoma: report of a case and review of the literature. | despite common endothelial origins, angiosarcoma and kaposi's sarcoma are clinically and histologically distinct vascular proliferations. the development of angiosarcoma in a chronically edematous abdominal pannus is extremely uncommon. similarly, tumors with the combined histologic features of angiosarcoma and kaposi's sarcoma have rarely been described. | 2006 | 16700780 |
| modulation of kaposi's sarcoma-associated herpesvirus infection and replication by mek/erk, jnk, and p38 multiple mitogen-activated protein kinase pathways during primary infection. | kaposi's sarcoma-associated herpesvirus (kshv) is etiologically associated with kaposi's sarcoma, a dominant aids-related tumor of endothelial cells, and several other lymphoproliferative malignancies. while activation of the phosphatidylinositol 3-kinase-protein kinase c-mek-erk pathway is essential for kshv infection, we have recently shown that kshv also activates jnk and p38 mitogen-activated protein kinase (mapk) pathways during primary infection (j. xie, h. y. pan, s. yoo, and s.-j. gao, j ... | 2006 | 16699017 |
| decrease in epstein-barr virus-positive aids-related lymphoma in the era of highly active antiretroviral therapy. | recent introduction of highly active antiretroviral therapy (haart) is reported to have reduced the incidence of lymphoma among hiv-infected individuals. a clinicopathological study was performed on 86 aids-related lymphoma patients who were treated in tokyo area from 1987 to 2005. the incidence of lymphoma detected by autopsy was 27% (53 cases/198 autopsies). diffuse large b cell lymphoma was the most predominant histological subtype throughout the period (78%). burkitt's lymphoma (bl) increase ... | 2006 | 16697236 |
| a prognostic index for aids-associated kaposi's sarcoma in the era of highly active antiretroviral therapy. | aids-associated kaposi's sarcoma remains common in individuals with hiv-1 infection in the era of highly active antiretroviral therapy (haart). we developed a simple model for predicting mortality on the basis of clinical characteristics present at the time of diagnosis of kaposi's sarcoma. | 2006 | 16679162 |
| solitary eyelid kaposi sarcoma in an hiv-negative patient. | to describe a case of localized kaposi sarcoma (ks) of the eyelid in an hiv-seronegative patient. | 2006 | 16670494 |
| histoid leprosy - unusual presentation. | a 39-year-old man presented with a chronic nonhealing toe ulcer and multiple skin-colored papules on the back, arms, and knees. from an initial small erosion, the toe lesion ulcerated over a 1.5-year period, while the papules progressed over a 6-month period, first appearing on the back and then spreading to the arms and knees. the past medical and family history were non-contributory. pertinent findings included the aforementioned well-defined, asymmetric, shiny papules (fig. 1). there were mul ... | 2006 | 16650172 |
| correlations between synthetic peptide-based enzyme immunoassays and immunofluorescence assay for detection of human herpesvirus 8 antibodies in different argentine populations. | human herpesvirus 8 (hhv-8) antibody tests vary in sensitivity and specificity, depending on the population tested and on the type of assay. in this study, we evaluated the sensitivity and specificity of two peptide enzyme immunoassays using a multiple antigenic peptide (pk8.1-map) or a chimeric peptide (pk8.1-orf65) as the antigens and determined the hhv-8 seroprevalence in different argentine populations using an immunofluorescence assay (ifa) as reference. for analysis, when either or both of ... | 2006 | 16628571 |
| cutaneous plasmacytosis: a report of five cases with immunohistochemical evaluation for hhv-8 expression. | cutaneous plasmacytosis is a rare disorder that typically affects middle-aged to older individuals of asian, particularly japanese, descent. clinically, it is characterized by multiple asymptomatic red-brown plaques and nodules on the trunk. lymphadenopathy and hypergammaglobulinemia may be present. histologically, the lesions show a moderately dense superficial and deep perivascular infiltrate composed predominantly of mature plasma cells without atypia or light chain restriction. we report our ... | 2006 | 16625068 |
| [development of drugs with antiherpetic activity]. | 2006 | 16620633 | |
| promoter switching allows simultaneous transcription of lana and k14/vgpcr of kaposi's sarcoma-associated herpesvirus. | latent transcription of the latency-associated nuclear antigen (lana/orf73) of kaposi's sarcoma-associated herpesvirus is driven by the lanap-c. complexity arises during lytic reactivation, however, as the bicistronic k14/vgpcr transcript initiates 32 bp downstream of lanap-c in the opposite orientation. we identify an rta/orf50-inducible lana promoter (lanap-i) that is distinct from the lanap-c. lanap-c is unaffected by rta/orf50. utilization of the second, downstream lanap-i explains how lana ... | 2006 | 16616289 |
| [kaposi's sarcoma]. | 2006 | 16615556 | |
| [epidemiology of kshv infection]. | 2006 | 16615545 | |
| [immune modulation by kshv]. | 2006 | 16615536 | |
| [classification and structure of gamma-herpesviruses]. | 2006 | 16615528 | |
| lymphatic and vascular origin of kaposi's sarcoma spindle cells during tumor development. | the histogenesis of kaposi's sarcoma (ks) tumor spindle cells (sc) remains controversial but several immunohistochemical studies favor a lymphatic origin. twenty ks surgical biopsies were analyzed for the coexpression of lana, cd34, lyve-1, d2-40, vegfr-2, vegfr3 by using double or triple immunostaining. most of the sc in both early and late ks expressed the lymphatic markers lyve-1, d2-40 and vegfr-3 and the blood vascular endothelial/endothelial precursor cell markers cd34 and endothelial stem ... | 2006 | 16615115 |
| raf/mek/erk signalling triggers reactivation of kaposi's sarcoma-associated herpesvirus latency. | kaposi's sarcoma-associated herpesvirus (kshv) causes kaposi's sarcoma, primary effusion lymphoma and multicentric castleman's disease. kshv infection of cells produces both latent and lytic cycles of infection. in vivo, the virus is found predominantly in the latent state. in vitro, a lytic infection can be induced in kshv-infected cells by treating with phorbol ester (tpa). however, the exact signalling events that lead to the reactivation of kshv lytic infection are still elusive. here, a rol ... | 2006 | 16603514 |
| regulation of intracellular signalling by the terminal membrane proteins of members of the gammaherpesvirinae. | the human gamma(1)-herpesvirus epstein-barr virus (ebv) and the gamma(2)-herpesviruses kaposi's sarcoma-associated herpesvirus (kshv), rhesus rhadinovirus (rrv), herpesvirus saimiri (hvs) and herpesvirus ateles (hva) all contain genes located adjacent to the terminal-repeat region of their genomes, encoding membrane proteins involved in signal transduction. designated 'terminal membrane proteins' (tmps) because of their localization in the viral genome, they interact with a variety of cellular s ... | 2006 | 16603506 |
| molecular evidence for mother-to-child transmission of kaposi sarcoma-associated herpesvirus in uganda and k1 gene evolution within the host. | epidemiological studies of kaposi sarcoma (ks)-related herpesvirus (kshv) indicate that having a kshv-seropositive mother is a risk factor for kshv infection in children. | 2006 | 16586362 |
| kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xct. | kaposi's sarcoma-associated herpesvirus (kshv, human herpesvirus 8) is the causative agent of kaposi's sarcoma and other lymphoproliferative syndromes often associated with hiv/aids. functional complementary dna selection for a receptor mediating kshv cell fusion identified xct, the 12-transmembrane light chain of the human cystine/glutamate exchange transporter system x-c. expression of recombinant xct rendered otherwise not susceptible target cells permissive for both kshv cell fusion and viri ... | 2006 | 16574866 |
| seroprevalence of six different viruses among pregnant women and blood donors in rural and urban burkina faso: a comparative analysis. | a seroprevalence study was carried out of six different human pathogenic viruses, namely human immunodeficiency virus (hiv), hepatitis b virus (hbv), hepatitis c virus (hcv), human t-cell leukemia virus (htlv), human herpesvirus type 8 (hhv-8), and dengue virus among pregnant women and blood donors from rural (nouna) and urban (ouagadougou) burkina faso, west africa. a total of 683 samples from blood donors (n = 191) and pregnant women (n = 492) were collected from both sites and screened for th ... | 2006 | 16555290 |
| characterization of kaposi's sarcoma-associated herpesvirus (kshv) k1 promoter activation by rta. | the k1 gene of kaposi's sarcoma-associated herpesvirus (kshv) encodes a 46-kda transmembrane glycoprotein that possesses transforming properties, initiates signaling pathways in b cells, and prevents apoptosis. here, we demonstrate a mechanism for activation of the k1 promoter by the rta transactivator. electrophoretic mobility shift assay (emsa) analysis of the k1 promoter demonstrated that purified rta protein bound to the k1 promoter at three locations, independent of other dna-binding factor ... | 2006 | 16546233 |
| the host control of lytic and latent infection with human herpesvirus-8. | 2006 | 16544244 | |
| kshv/hhv-8 infection of human hematopoietic progenitor (cd34+) cells: persistence of infection during hematopoiesis in vitro and in vivo. | the cellular reservoir for kaposi sarcoma-associated herpesvirus (kshv) infection in the hematopoietic compartment and mechanisms governing latent infection and reactivation remain undefined. to determine susceptibility of human cd34+ hematopoietic progenitor cells (hpcs) to infection with kshv, purified hpcs were exposed to kshv, and cells were differentiated in vitro and in vivo. clonogenic colony-forming activity was significantly suppressed in kshv-infected cd34+ cells, and viral dna was pre ... | 2006 | 16543476 |
| anatomical mapping of human herpesvirus reservoirs of infection. | following primary infection, all eight human herpesviruses persist lifelong in the human host. however, a mapping of all anatomic sites of human herpesvirus persistence is lacking. fresh tissue specimens representing approximately 40 major anatomic sites from eight autopsies were screened using a recently developed real-time pcr method for detection of all eight human herpesviruses. patients with evidence of active herpesvirus infection (herpes simplex 1 (hsv-1), herpes simplex 2 (hsv-2), varice ... | 2006 | 16528368 |
| quantitative and functional defects of dendritic cells in classic kaposi's sarcoma. | in this study, we investigated whether dendritic cells (dcs) are altered in classic kaposi's sarcoma (cks), a lympho-angioproliferative disorder associated with human herpesvirus-8 (hhv-8) infection. by direct analysis of peripheral blood dcs (pbdcs), we demonstrated that cks patients have lower frequency of myeloid and plasmacytoid dcs than controls. this reduction was greater in patients with advanced stages of disease. pbdcs from cks patients also showed up-regulated expression of the scaveng ... | 2006 | 16527545 |
| kaposi's sarcoma triggered by endogenous hhv-8 reactivation after non-myeloablative allogeneic haematopoietic transplantation. | human herpesvirus 8 (hhv-8) is causally associated with kaposi's sarcoma (ks). ks is most frequently observed in hiv patients and in solid organ transplant recipients. the role of hhv-8 in allogeneic haematopoietic cell transplantation (hct) remains to be determined. here we describe a case in which ks concomitantly occurred with cmv reactivation after a non-myeloablative allogeneic hct and presented with skin lesions, but not visceral involvement. skin biopsy confirmed the diagnosis and ruled o ... | 2006 | 16519707 |
| phosphorylation of the cyclin-dependent kinase inhibitor p21cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21cip1-imposed g1 arrest. | k cyclin encoded by kaposi's sarcoma-associated herpesvirus confers resistance to the cyclin-dependent kinase (cdk) inhibitors p16ink4a, p21cip1, and p27kip1 on the associated cdk6. we have previously shown that k cyclin expression enforces s-phase entry on cells overexpressing p27kip1 by promoting phosphorylation of p27kip1 on threonine 187, triggering p27kip1 down-regulation. since p21cip1 acts in a manner similar to that of p27kip1, we have investigated the subversion of a p21cip1-induced g1 ... | 2006 | 16508017 |
| simultaneous occurrence of hodgkin's lymphoma and kaposi's sarcoma within the same lymph nodes of a non-aids patient. | we report a case of simultaneous occurrence of hodgkin's lymphoma and kaposi's sarcoma within the same lymph nodes of a 61-year-old woman without human immunodeficiency virus (hiv) infection. epstein-barr virus (ebv) was detected in the hodgkin cells and reed-sternberg cells by ebv lmp-1 immunostaining and epstein-barr virus encoded early rna (eber) in situ hybridization. in contrast, kaposi's sarcoma cells were positive for human herpes virus 8. this case is documented because the occurrence of ... | 2006 | 16501843 |
| rhesus rhadinovirus r15 encodes a functional homologue of human cd200. | a viral cd200 homologue (vcd200) encoded by open reading frame r15 of rhesus rhadinovirus (rrv), a gammaherpesvirus closely related to human herpesvirus 8 (hhv-8), is described here. rrv vcd200 shares 30% and 28% amino acid identity with human cd200 (hucd200) and hhv-8 vcd200, respectively. in vitro analysis indicated that an fc fusion (vcd200-fc) is expressed as a glycoprotein with a core molecular mass of 53 kda. utilizing monoclonal antibodies raised against vcd200-fc, vcd200 expression was d ... | 2006 | 16501121 |
| the latency-associated nuclear antigen of kaposi sarcoma-associated herpesvirus induces b cell hyperplasia and lymphoma. | kaposi sarcoma-associated herpesvirus (kshv) is a human lymphotropic herpesvirus. it is implicated in b cell neoplasias such as primary effusion lymphoma and multicentric castleman disease in aids patients. the kshv latency-associated nuclear antigen (lana) is consistently expressed in all kshv-associated tumor cells and was shown to bind the tumor suppressor proteins p53 and prb. to test lana's contribution to lymphomagenesis in vivo we generated transgenic mice expressing lana under the contro ... | 2006 | 16498502 |
| transcriptional origin of kaposi's sarcoma-associated herpesvirus micrornas. | kaposi's sarcoma-associated herpesvirus (kshv) encodes 11 distinct micrornas, all of which are found clustered within the major latency-associated region of the kshv genome in the same transcriptional orientation. because the kshv micrornas are all expressed in latently infected cells and are largely unaffected by induction of lytic replication, it appeared probable that they would be processed out of kshv transcripts that are derived from a latent promoter(s) present in this region. here, we de ... | 2006 | 16474131 |
| the nucleosomal surface as a docking station for kaposi's sarcoma herpesvirus lana. | kaposi's sarcoma-associated herpesvirus (kshv) latency-associated nuclear antigen (lana) mediates viral genome attachment to mitotic chromosomes. we find that n-terminal lana docks onto chromosomes by binding nucleosomes through the folded region of histones h2a-h2b. the same lana residues were required for both h2a-h2b binding and chromosome association. further, lana did not bind xenopus sperm chromatin, which is deficient in h2a-h2b; chromatin binding was rescued after assembly of nucleosomes ... | 2006 | 16469929 |
| human herpesvirus-8 in kaposi's sarcoma of the conjunctiva in a patient with aids. | to demonstrate human herpesvirus-8 (hhv-8) in kaposi's sarcoma (ks) of the conjunctiva in a patient with acquired immunodeficiency syndrome (aids). | 2006 | 16453181 |
| susceptibility to mycobacterial infections due to interferon-gamma and interleukin-12 pathway defects. | a case of interferon-gamma (ifn-gamma)/interleukin-12 (il-12) pathway defect is presented. pathophysiology, clinical characteristics, diagnostic test, and case management are reviewed. clinical pearls and pitfalls include: (1) a high probability of a defect in the ifn-gamma/il-12 cascade exists in patients with disseminated or recurrent infection due to poorly pathogenic mycobacteria or systemic infections caused by non-typhi salmonella species that are persistent and recurrent despite antibioti ... | 2005 | 16450579 |
| cutaneous malignancy and human immunodeficiency virus disease. | certain skin cancers occur with increased frequency or altered course in patients infected with hiv. malignant melanoma and squamous cell carcinoma are examples of cutaneous malignancies that have a more aggressive course in patients with hiv. others, such as basal cell carcinoma, appear more frequently in this population but do not appear to be more aggressive. the incidence of hiv-associated kapsosi's sarcoma has markedly decreased since the advent of hiv antiretroviral therapy. our understand ... | 2006 | 16443048 |
| the kaposi's sarcoma-associated herpesvirus complement control protein (kcp) binds to heparin and cell surfaces via positively charged amino acids in ccp1-2. | the kaposi's sarcoma-associated herpesvirus (kshv) complement control protein (kcp) inhibits the human complement system, and is similar in structure and function to endogenous complement inhibitors. other inhibitors such as c4b-binding protein and factor h, as well as the viral homologue vaccinia virus complement control protein are known to bind heparin and, for the two latter, also to glycosaminoglycans at the surface of cells. we report here that kcp also binds to heparin at physiological io ... | 2006 | 16442624 |
| dc-sign is a receptor for human herpesvirus 8 on dendritic cells and macrophages. | human herpesvirus 8 (hhv-8) causes kaposi's sarcoma and pleural effusion lymphoma. in this study, we show that dendritic cell-specific icam-3 grabbing nonintegrin (dc-sign; cd209) is a receptor for hhv-8 infection of myeloid dcs and macrophages. dc-sign was required for virus attachment to these cells and dc-sign-expressing cell lines. hhv-8 binding and infection were blocked by anti-dc-sign mab and soluble dc-sign, and mannan, a natural ligand for dc-sign. infection of dcs and macrophages with ... | 2006 | 16424204 |
| epidemiology of kaposi's sarcoma herpesvirus (hhv8) in västerbotten county, sweden. | a population-based serosurvey of human herpesvirus type 8 (hhv8) in västerbotten county, an area of northern sweden with high incidence of kaposi's sarcoma, was conducted. serum samples from an age- and sex-stratified random sample of 520 subjects (260 men and 260 women) participating in a population-based biobanking project were tested for antibodies against hhv8, using a sensitive indirect immunofluorescence assay to latent and lytic hhv8 antigens. buffy coat dna was also analyzed for viral dn ... | 2006 | 16419115 |
| focal adhesion kinase is critical for entry of kaposi's sarcoma-associated herpesvirus into target cells. | kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (kshv/hhv-8) interacts with cell surface alpha3beta1 integrin early during in vitro infection of human endothelial cells and fibroblasts and activates the focal adhesion kinase (fak) that is immediately downstream in the outside-in signaling pathway by integrins, leading to the activation of several downstream signaling molecules. in this study, using real-time dna and reverse transcription-pcr assays to measure total internalized viral ... | 2006 | 16414994 |
| risk factors for human herpesvirus 8 seropositivity in the aids cancer cohort study. | cigarette smoking has been associated with a decreased risk for aids-related and classical ks, but whether it is associated with decreased risk of human herpesvirus 8 (hhv-8) infection is unknown. | 2006 | 16414306 |
| iatrogenic kaposi's sarcoma following steroid therapy for nonspecific interstitial pneumonia with hhv-8 genotyping. | we present a case of iatrogenic kaposi's sarcoma (ks) in a 64-year-old, human immunodeficiency virus (hiv)-negative woman with nonspecific interstitial pneumonia (nsip) following steroid therapy. she suffered from longstanding exertional dyspnea, and was diagnosed to have nsip by a thoracoscopic lung biopsy. after 4 months of steroid therapy, multiple purplish nodular or patchy skin lesions developed throughout the entire body. microscopically, the skin lesions, consisting of closely packed spin ... | 2006 | 16413694 |
| systems biology. when proteomes collide. | 2006 | 16410514 | |
| multicentric castleman's disease in a patient with hiv. | multicentric castleman's disease (mcd) was originally described in non-hiv patients. it is a rare lymphoproliferative disorder, which is more commonly seen in hiv-positive patients and is associated with human herpes virus-8 (hhv-8). we describe a patient with advanced hiv who responded well to conventional highly active antiretroviral treatment. she was diagnosed with mcd soon after her diagnosis of hiv. she presented with multiple flares of her mcd. the case illustrates the difficulty of diffe ... | 2006 | 16409683 |
| localization of human herpesvirus type 8 in human sperms by in situ pcr. | defining the mechanism of infection with human herpesvirus-8 (hhv-8) or kaposi's sarcoma associated herpesvirus (kshv) is an important clinical issue. hhv-8 has been linked to kaposi's sarcoma (ks) development in hiv-1-infected individuals, and ks develops in 40% of those infected with both viruses. a series of epidemiological data suggest that sexual transmission is one of the routes of transmission for hhv-8. in our studies, we sought to assess the cellular reservoirs of hhv-8 dna in the semen ... | 2006 | 16402152 |
| the kaposi's sarcoma-associated herpesvirus g protein-coupled receptor as a therapeutic target for the treatment of kaposi's sarcoma. | the kaposi's sarcoma-associated herpesvirus (kshv) encodes a g protein-coupled receptor (vgpcr) that has been implicated in the initiation of kaposi's sarcoma, identifying vgpcr as an attractive target for preventing kaposi's sarcoma. however, as only a fraction of cells in advanced kaposi's sarcoma lesions express vgpcr, it is unclear whether this unique viral oncogene contributes to kaposi's sarcoma progression. we therefore set out to determine whether the few cells that express vgpcr in esta ... | 2006 | 16397229 |
| prognostic factors in human herpesvirus 8-related lymphoproliferative disorders associated with hiv infection. | 2006 | 16382129 | |
| nf-kappab is essential for the progression of kshv- and ebv-infected lymphomas in vivo. | activated nf-kappab is a critical mechanism by which lymphoma cells infected by epstein-barr virus (ebv/hhv-4) and kaposi sarcoma herpesvirus (kshv/hhv-8) are protected from apoptotic stress. selective pharmacologic inhibition of constitutive nf-kappab activity induces apoptosis in kshv- and ebv-infected lymphoma cells. in both tumor types, pharmacologic inhibition of nf-kappab in vitro induced identical mitochondrially mediated apoptosis cascades. assessment of gene regulation by microarray ana ... | 2006 | 16380446 |
| the epidemiology of non-hodgkin lymphoma. | non-hodgkin lymphoma (nhl) includes a group of more than 20 different malignant lymphoproliferative diseases that originate from lymphocytes. rates of nhl have increased dramatically over the past few decades, although the rate of increase has recently slowed. it is now the sixth most common cancer in australia. globally, it is somewhat more common in men than in women, and rates are highest in north america and australia. the causes of the increase in nhl rates are largely unknown. the best des ... | 2005 | 16373224 |
| effect of extremely low frequency electromagnetic fields (elf-emf) on kaposi's sarcoma-associated herpes virus in bcbl-1 cells. | association between extremely low frequency electromagnetic fields (elf-emf) and human cancers is controversial, and few studies have been conducted on their influence on oncogenic viruses. we studied the effects of 1 mt, 50 hz sine waves, applied for 24-72 h, on kaposi's sarcoma (ks)-associated herpesvirus (kshv or hhv-8) in bcbl-1, a latently infected primary effusion lymphoma (pel) cell line. elf-emf exposure did not affect the growth and viability of bcbl-1 cells, either stimulated or not wi ... | 2006 | 16342195 |
| sexual behaviour and human herpesvirus 8 infection in homosexual men in australia. | human herpesvirus 8 (hhv-8) is a common sexually transmitted agent among homosexual men, but there are few australian data. we aimed to describe the prevalence and risk factors for seropositivity to hhv-8 in australian homosexual men. | 2005 | 16334707 |
| pathogenesis of gammaherpesvirus infections. | gammaherpesviruses are members of an emerging subfamily among the herpesviridae. two genera are discriminated: (i) lymphocryptovirus, including its type species epstein-barr virus (ebv), and (ii) rhadinovirus, including viruses of interest for medicine, veterinary medicine, and biomedical research, i.e. alcelaphine herpesvirus 1, bovine herpesvirus 4, equine herpesvirus 2, human herpesvirus 8, mouse herpesvirus 68, and ovine herpesvirus 2 (ovhv-2). the perception that these viruses have a narrow ... | 2006 | 16332416 |
| fatal hhv-8-associated hemophagocytic syndrome in an hiv-negative immunocompetent patient with plasmablastic variant of multicentric castleman disease (plasmablastic microlymphoma). | virus-associated hemophagocytic syndrome (vahs) triggered by hhv-8 is extremely rare and has been reported only in 9 immunocompromised patients. we report the first case of hhv-8-associated vahs in an hiv-negative, immunocompetent patient with plasmablastic variant (plasmablastic microlymphoma) of multicentric castleman disease (mcd). this 61-year-old man presented with fever, cough, and bilateral inguinal lymphadenopathy. biopsy of the right inguinal lymph node revealed plasmablastic mcd with n ... | 2006 | 16330952 |
| plasmablastic lymphoma in hiv-positive patients: an aggressive epstein-barr virus-associated extramedullary plasmacytic neoplasm. | aids-associated aggressive b-cell lymphomas often have plasmacytoid features. plasma cell neoplasms in hiv patients were commonly described to have atypical morphology and an aggressive clinical course in the literature. we reviewed 14 cases of neoplasms with marked plasmacytic differentiation in hiv-positive patients to determine their clinicopathologic features. of these, 13 of 14 had homogeneous morphology and were generally cd45(+), cd20-, pax-5-, and cd138(+). all were positive for epstein- ... | 2005 | 16327436 |
| the kshv oncoprotein vflip contains a traf-interacting motif and requires traf2 and traf3 for signalling. | primary effusion lymphomas (pels) characterized by infection with the kaposi's sarcoma herpesvirus (kshv; also called human herpesvirus 8) depend on the expression of the viral fadd-like interleukin-1-beta-converting enzyme (flice)/caspase-8-inhibitory protein (vflip) for their survival. this effect is achieved by activation of the transcription factor nuclear factor-kappab (nf-kappab). tumour necrosis factor (tnf) receptor-associated factors (trafs) are direct mediators of nf-kappab signalling ... | 2006 | 16311516 |
| kaposi's sarcoma-associated herpesvirus induction of ap-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways. | kaposi's sarcoma is an angioproliferative disseminated tumor of endothelial cells linked to infection with kaposi's sarcoma-associated herpesvirus (kshv). ap-1 transcription factors are involved in diverse biological processes, including infection and replication of viruses, cell growth, oncogenesis, angiogenesis, and invasion of cancer cells. here we show that kshv activates ap-1 during primary infection. the activation of ap-1 at the early stage of kshv infection is mainly mediated by virus en ... | 2005 | 16306573 |
| multiplex pcr-based dna array for simultaneous detection of three human herpesviruses, evb, cmv and kshv. | human lymphotropic herpesviruses, epstein-barr virus (ebv), cytomegalovirus (cmv) and kaposi's sarcoma-associated herpesvirus (kshv) are responsible for a wide variety of human diseases. due to an increase in diseased states associated with immunosuppression, more instances of co-morbid infections with these herpesviruses have resulted in viral reactivations that have caused numerous fatalities. therefore, the development of rapid and accurate method to detect these viruses in immunocompromised ... | 2006 | 16298362 |
| gamma-herpesvirus neoplasia: a growing role for cox-2. | both human gamma-herpesviruses, epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) induce neoplasia. burkitt's and hodgkin's lymphomas harbor ebv sequences, while kshv has been associated with kaposi's sarcoma (ks), primary effusion lymphoma (pel), and multicentric castleman's disease (mcd). each of these gamma-herpesvirus-associated malignancies displays typical characteristics of neoplasia, such as angiogenesis and cell survival. one enzyme commonly overexpressed in br ... | 2005 | 16276519 |
| reversibility of pulmonary arterial hypertension in hiv/hhv8-associated castleman's disease. | the present study describes a case of pulmonary arterial hypertension (pah) associated with multicentric castleman's disease in a patient infected with hiv type 1 and human herpes virus 8. therapy included highly active antiretroviral therapy, warfarin, diuretics, continuous i.v. epoprostenol and 12-monthly pulses of cyclophosphamide. the patient's condition improved dramatically with complete reversibility of pah, allowing weaning of continuous i.v. epoprostenol therapy. after 5 yrs, both castl ... | 2005 | 16264059 |
| [kaposi's sarcoma]. | in recent years large amounts of findings have accumulated about kaposi's sarcoma, a virus induced angioproliferative disorder appearing in four clinical forms: classical, epidemic, endemic and iatrogenic, as it has been in focus of not only from the dermatologic but also from the viral tumorgenesis perspective. the common characteristics are the histopathological appearance, the causative role of the human herpesvirus 8 and the similar clinical picture (bluish-red macules, papules, and nodes). ... | 2005 | 16259333 |
| transcripts encoding k12, v-flip, v-cyclin, and the microrna cluster of kaposi's sarcoma-associated herpesvirus originate from a common promoter. | kaposi's sarcoma-associated herpesvirus (kshv) is the causative agent of three malignancies associated with aids and immunosuppression. tumor cells harbor latent virus and express kaposin (open reading frame [orf] k12), v-flip (orf 71), v-cyclin (orf 72), and latency-associated nuclear antigen (lana; orf 73). orfs 71 to 73 are transcribed as multicistronic rnas initiating from adjacent constitutive and inducible promoters upstream of orf 73. here we characterize a third promoter embedded within ... | 2005 | 16254382 |
| induced structure of a helical switch as a mechanism to regulate enzymatic activity. | herpesviruses encode a protease that is activated by homodimerization at high enzyme concentrations during lytic replication. the homodimer contains two active sites, which are distal from the dimer interface. assignment of backbone nmr resonances and engineering of a redox switch show that two helices position a loop containing catalytic residues within each active site. | 2005 | 16244665 |
| extracavitary primary effusion lymphoma of the anorectum. | we report a case of an extracavitary primary effusion lymphoma occurring in the anorectum of a patient with advanced acquired immune deficiency syndrome. the morphology, null cell immunophenotype, and acquisition of plasma cell markers in this case are typical of the so-called solid variant of primary effusion lymphoma. lymphoma cells in this case were shown to be co-infected with human herpesvirus-8 and epstein-barr virus. following combination chemotherapy and highly active antiretroviral ther ... | 2005 | 16231856 |
| human herpesvirus 8 infection in patients with cutaneous lymphoproliferative diseases. | to investigate the prevalence of human herpesvirus 8 (hhv-8; kaposi sarcoma-associated herpesvirus) infection in patients with lymphoproliferative skin diseases such as large-plaque parapsoriasis (lpp) and mycosis fungoides compared with inflammatory cutaneous conditions or healthy control subjects. | 2005 | 16230560 |
| human herpesvirus 8 and pulmonary hypertension. | human herpesvirus 8 (hhv-8) antibodies were detected in 1 of 33 patients with pulmonary hypertension (including in 1 of 16 with idiopathic pulmonary arterial hypertension), 5 of 29 with cystic fibrosis, and 3 of 13 with interstitial lung disease. no relationship between hhv-8 infection and pulmonary hypertension was found. | 2005 | 16229789 |
| brd2/ring3 interacts with a chromatin-binding domain in the kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (lana-1) that is required for multiple functions of lana-1. | latency-associated nuclear antigen 1 (lana-1) of kaposi's sarcoma-associated herpesvirus (kshv) mediates the episomal replication of the kshv genome, as well as transcriptional regulation, in latently infected cells. interaction of lana-1 with cellular chromatin is required for both these functions. an n-terminal heterochromatin-binding site in lana-1 is essential for the replication and maintenance of latent episomes, as well as transcriptional regulation. we have recently described a c-termina ... | 2005 | 16227282 |
| the herpesvirus saimiri replication and transcription activator acts synergistically with ccaat enhancer binding protein alpha to activate the dna polymerase promoter. | the open reading frame (orf) 50 gene product, also known as the replication and transcription activator (rta), is an immediate-early gene which is well conserved among all gamma-2 herpesviruses and plays a pivotal role in regulating the latent-lytic switch. herpesvirus saimiri (hvs) orf 50a functions as a sequence-specific transactivator capable of activating delayed-early (de) gene expression via binding directly to an orf 50 response element (re) within the respective promoter. analysis of the ... | 2005 | 16227275 |
| immune mechanisms in murine gammaherpesvirus-68 infection. | the murine gamma-herpesvirus-68 (mhv-68) is a relative of the kaposi's sarcoma-associated herpesvirus (kshv) and epstein-barr virus (ebv) that infects mice. all these gamma-herpesviruses are subject to immune control, but limit the impact of this control through immune evasion. molecular evasion mechanisms have been described in abundance. however, we can only speculate what ebv and kshv immune evasion contributes to the viral lifecycle. with mhv-68, we can analyze in vivo the contribution of im ... | 2005 | 16212523 |
| an unusual case of posttransplant peritoneal primary effusion lymphoma with t-cell phenotype in a hiv-negative female, not associated with hhv-8. | primary effusion lymphoma (pel) is a recently individualized form of non-hodgkin's lymphoma (who classification) that mainly develops in hiv infected males, more frequently in homosexuals and advanced stages of the disease (total cd4+ lymphocyte count below 100-200/microl). occasionally, it appears in other immunodepressive states (such as solid organs transplant period) and even, although very rarely, in immunocompetent patients. from a pathogenetic point of view, pel has been related to kaposi ... | 2005 | 16195773 |
| kshv/hhv-8 associated lymph node based lymphomas in hiv seronegative subjects. report of two cases with anaplastic large cell morphology and plasmablastic immunophenotype. | kaposi sarcoma associated herpesvirus (kshv)/human herpesvirus 8 (hhv-8) associated lymphomas, which often develop in human immunodeficiency virus (hiv) infected patients with advanced aids, present predominantly as primary effusion lymphoma (pel) or, less frequently, as "solid" extracavitary based lymphomas, associated with serous effusions. these last lymphomas, also called "solid pel", have been reported before the development of an effusion lymphoma and after resolution of pel. interestingly ... | 2005 | 16189148 |
| down-regulation of basophil function by human cd200 and human herpesvirus-8 cd200. | human and rodent cd200 are recognized by the inhibitory cd200r, and these molecules play an important role in the regulation of the immune system. several viruses, such as human herpesvirus-6 (hhv-6), hhv-7, and hhv-8, possess a cd200 homologue, suggesting that these viruses regulate the immune response via cd200r. in this study, we analyzed the effect of human cd200 and the viral cd200 homologues on human cd200r-expressing cells. we found that human cd200r is predominantly expressed on basophil ... | 2005 | 16177086 |
| kshv viral cyclin inactivates p27kip1 through ser10 and thr187 phosphorylation in proliferating primary effusion lymphomas. | kaposi sarcoma herpesvirus (kshv) infection is consistently associated with primary effusion lymphomas (pels) that are non-hodgkin lymphomas of b-cell origin. all pel cells are latently infected with kshv and express latent viral proteins such as the viral cyclin (v-cyclin), which has previously been implicated in down-regulation of cell-cycle inhibitor p27(kip1) levels via phosphorylation on thr187. pel cells retain high levels of p27(kip1) but yet proliferate actively, which has left the biolo ... | 2006 | 16160006 |
| prevalence of some herpesviruses in gingival crevicular fluid. | the herpesviruses, ancient pathogens which have co-evoluted with human, are etiologically associated with a number of diseases, from asymptomatic to oncogenic and mortal diseases. it seems that some of them have also an important role in the pathogenesis of human periodontal disease. | 2005 | 16157267 |
| human herpesvirus 8 serological markers and viral load in patients with aids-associated kaposi's sarcoma in central african republic. | epidemic kaposi's sarcoma (ks) is one of the most frequent types of cancer in several african countries; however, very few data are available on human herpesvirus 8 (hhv-8) markers in ks patients from central africa. in a series of 36 aids-ks cases from central african republic, we showed, using a real-time pcr quantitative assay, the high frequency (82%) of detectable hhv-8 dna in peripheral blood mononuclear cells (pbmcs). we also found that the level of antibodies directed against lytic or la ... | 2005 | 16145154 |
| crystal structure of viral macrophage inflammatory protein i encoded by kaposi's sarcoma-associated herpesvirus at 1.7a. | viral macrophage inflammatory protein i (vmip-i) is a chemokine encoded by the kaposi's sarcoma-associated herpesvirus (kshv) that selectively activates the cc chemokine receptor 8 (ccr8), for which the endogenous ligand is ccl1. the crystal structure of vmip-i was determined at 1.7a for comparison with other chemokines, especially those that bind ccr8, such as vmip-ii from kshv, a ccr8 antagonist and the closest homolog (40% identical). vmip-i has a typical chemokine fold consisting of an exten ... | 2005 | 16140327 |
| t- and b-cell clonality and frequency of human herpes viruses-6, -8 and epstein barr virus in angioimmunoblastic t-cell lymphoma. | angioimmunoblastic t-cell lymphoma (t-ail) is a peripheral t-cell lymphoma of unknown etiology. previous clonality studies have shown a heterogeneous composition of this disease with varying restrictions of b- and t-cell populations in the tumour. for the first time in a single study and in the same pathological materials, we have analysed, lymphoid cell clonality and occurrence of human herpes viruses and epstein barr virus. of 18 cases 12 (66.6%) had clonal t- and three (16.6%) had clonal b-ce ... | 2004 | 16134192 |
| constitutive nf-kappab activation, normal fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 k13 transgenic mice. | human herpesvirus 8 (hhv-8, also called kaposi's sarcoma-associated herpes virus) has been linked to kaposi's sarcoma and primary effusion lymphoma. hhv-8-encoded viral fas-associated death domain-like il-1-converting enzyme inhibitory protein (vflip) is one of the few viral proteins to be expressed in latently infected cells and plays a key role in the survival and proliferation of primary effusion lymphoma cells. two main functions have been ascribed to hhv-8 vflip, inhibition of caspase 8/fas ... | 2005 | 16120683 |
| envelope glycoprotein gb of kaposi's sarcoma-associated herpesvirus is essential for egress from infected cells. | kaposi's sarcoma-associated herpesvirus (kshv) envelope glycoprotein gb interacts with cell surface heparan sulfate (hs) and alpha3beta1 integrin and plays roles in the initial binding and entry into the target cells and in the induction of preexisting host cell signal pathways. to define gb function further, using a bacterial artificial chromosome (bac) system carrying the kshv genome (bac36wt-kshv), we constructed a recombinant virus genome with the gb open reading frame (orf) deleted by repla ... | 2005 | 16103147 |
| increasing seroprevalence of human herpesvirus 8 (hhv-8) with age confirms hhv-8 endemicity in amazon amerindians from brazil. | human herpesvirus 8 (hhv-8) seroprevalences were determined in two isolated amazon amerindian tribes, according to age, gender and familial aggregation. plasma and serum samples obtained from 982 amazon amerindians (664 tiriyó and 318 waiampi) were tested for antibodies against lytic and latent hhv-8 antigens by using 'in-house' immunofluorescence assays. overall, hhv-8 seroprevalence was 56.8 % (57.4 % in the tiriyó tribe and 55.7 % in the waiampi tribe). seroprevalence was independent of gende ... | 2005 | 16099900 |
| epidemiology and clinical characteristics of classic kaposi's sarcoma, seroprevalence, and variants of human herpesvirus 8 in south america: a critical review of an old disease. | to review the current south american literature on classic kaposi's sarcoma (ks) and human herpesvirus 8 (hhv-8), and point the way for studies that still need to be performed. | 2005 | 16095940 |
| targeting human herpesvirus-8 for treatment of kaposi's sarcoma and primary effusion lymphoma. | human herpesvirus-8, also called the kaposi's sarcoma herpesvirus, is present in all cases of kaposi's sarcoma and primary effusion lymphoma and in some cases of multicentric castleman's disease. this review discusses mechanisms by which human herpesvirus-8 contributes to tumorigenesis and how this knowledge can be used to target the virus for the treatment of these tumors. | 2005 | 16093794 |
| linking kshv to human cancer. | kaposi's sarcoma-associated herpesvirus (kshv), also known as human herpesvirus 8 (hhv-8), has been linked to several malignancies in humans. kshv is the etiologic agent associated with the development of kaposi's sarcoma (ks), primary effusion lymphoma (pel), and multicentric castleman's disease (mcd). kshv is a double-stranded dna virus that has been classified as a gammaherpesvirus. here, we review the association of kshv with human cancer, viral genes that may potentially be involved in the ... | 2005 | 16091195 |
| epigenetic mechanisms do not control viral latency iii in primary effusion lymphoma cells infected with a recombinant epstein-barr virus. | 2005 | 16079894 | |
| hhv-8 and ebv are not commonly found in idiopathic pulmonary fibrosis. | idiopathic pulmonary fibrosis/usual interstitial pneumonia (ipf/uip) is a diffuse and progressive lung disease whose pathogenesis is incompletely understood. recently, the presence of herpesvirus-specific dna was detected in the large majority of cases of a series of ipf/uip and other lung interstitial diseases. we have therefore tested our own ipf/uip series for the presence of hhv-8 and ebv proteins. | 2005 | 16053027 |
| immunohistochemical and molecular assessment of human herpesvirus type 8 in gastrointestinal tumours. | gastrointestinal stromal tumours (gists) are the most common mesenchymal tumours of the gastrointestinal tract, histologically identified as highly cellular spindle or epithelioid cell tumours, and often positive for cd34 (60-70%). kaposi's sarcomas (kss) are similar to gists: they are most often found in the gastrointestinal tract (although cutaneous lesions do occur), they are also composed of spindle or epithelioid cells (although erythrocytes are also seen), and the tumour cells are nearly a ... | 2005 | 16049289 |
| downregulation of the major histocompatibility complex class i molecules by human herpesvirus type 8 and impaired natural killer cell activity in primary effusion lymphoma development. | primary effusion lymphomas (pels) are invariably infected by human herpesvirus type 8 (hhv8) and often co-infected by epstein-barr virus (ebv). we found that expression of major histocompatibility complex class i (mhc-i) surface molecules was significantly decreased in pel cells when compared with hhv8 negative lymphomas, irrespective of ebv infection. mhc-i downregulation rendered pel cells sensitive to recognition and killing by natural killer (nk) cells. intriguingly, analysis of mhc-i non-re ... | 2005 | 16044583 |
| processivity factor of kshv contains a nuclear localization signal and binding domains for transporting viral dna polymerase into the nucleus. | kaposi's sarcoma-associated human herpesvirus (kshv) encodes a processivity factor (pf-8, orf59) that forms homodimers and binds to viral dna polymerase (pol-8, orf9). pf-8 is essential for stabilizing pol-8 on template dna so that pol-8 can incorporate nucleotides continuously. here, the intracellular interaction of these two viral proteins was examined by confocal immunofluorescence microscopy. when individually expressed, pf-8 was observed exclusively in the nucleus, whereas pol-8 was found o ... | 2005 | 16043206 |
| a relapsing inflammatory syndrome and active human herpesvirus 8 infection. | we describe an immunocompetent 61-year-old woman who was negative for human immunodeficiency virus and who had recurrent human herpesvirus 8 (hhv-8) infection associated with a relapsing systemic inflammatory syndrome characterized by fever, lymphadenopathy, splenomegaly, edema, arthrosynovitis, and rash. kaposi's sarcoma developed 10 months after the initial clinical presentation. a correlation was documented between the recurrent clinical manifestations and the hhv-8 load in plasma and periphe ... | 2005 | 16014885 |
| functional genomics and the development of pathogenesis-targeted therapies for kaposi's sarcoma. | kaposi's sarcoma (ks) is a multifocal angioproliferative disorder affecting the skin, mucosa and viscera of individuals infected with human herpesvirus-8 (hhv-8; also kaposi's sarcoma-associated herpesvirus [kshv]). ks is the most common neoplasm in aids patients; the clinical outcome of aids-ks is significantly improved by highly active antiretroviral therapy (haart). however, in africa, where the severest manifestations of ks occur, there is limited access to these and other effective but expe ... | 2005 | 16013955 |