Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| tandemly arranged gene clusters of malarial parasites that are highly conserved and transcribed. | a molecular clone containing a 5.8 kb eco ri fragment was isolated from a genomic library of the rodent malarial parasite plasmodium yoelii. the p. yoelii genome contains about 150 copies of this sequence, making up almost 3% of the dna. these sequences are tandemly arrayed in head-to-tail configurations with the unit length of the repeat being 5.8 kb. several poly(a+) rnas of p. yoelii ranging from 1.6 to 0.3 kb are recognized by the 5.8 kb clone. five additional species of malarial parasites ( ... | 1987 | 3033497 |
| homologous telomeric sequences are present in different species of the genus plasmodium. | the telomeric sequence cloned from plasmodium berghei (see m. ponzi et al. (1985) embo j. 4, 2991-2995) was tested for species specificity. a telomeric and a subtelomeric fragment of the cloned insert served as separate, labelled probes on pulsed field gradient electrophoretical patterns and on genomic digests from the rodent malarias plasmodium yoelii, plasmodium chabaudi and from the human malaria plasmodium falciparum. results indicate that the subtelomeric fragment, abundantly represented in ... | 1986 | 3024000 |
| cephalo-adrenal interactions in the broader context of pragmatic and theoretical rhythm models. | some of the literature on modeling of biological rhythms with mathematical, physical, chemical, biochemical, in vivo and in vitro oscillations is succintly annotated. the need for biologic models that account for the interaction of 3 or more periodic entities is indicated, documented and illustrated, with emphasis on the cephalo-adrenal network of rodents. patterns of interaction, in this context, involve attenuation, no-effect and/or amplification by a third entity, the modulator, of the effect ... | 1986 | 3015508 |
| plasmodium berghei: reaction of sporozoites with chemically and enzymatically modified hepatoma cells. | plasmodium berghei sporozoites were observed to react with human hepatoma (hepg2) target cells which had been fixed with methanol, formaldehyde, or glutaraldehyde. the reaction consisted of attachment of sporozoites to the fixed target cells and the release of circumsporozoite protein which bound to target cell areas adjacent to the attachment sites. treatment of fixed target cells with 0.1 n h2so4 at 80 c, neuraminidases, neuraminidase plus galactose oxidase or inclusion of transferrin, orosomu ... | 1986 | 3013669 |
| effects of antimalarial drugs on oxygen consumption by erythrocytes infected with plasmodium berghei: an esr study. | oxygen consumption in mouse erythrocytes infected with plasmodium berghei has been followed by electron spin resonance (esr) spectroscopy of nitroxide radical spin probes. the parasitized red cell suspension is mixed with the spin probe ctpo (3-carbamoyl-2,2,5,5-tetramethyl-3-pyrrolin-1-yloxy) in a closed chamber. oxygen consumption is monitored by the increasing resolution of the superhyperfine splittings of the spin label. the antimalarial drugs quinacrine, primaquine, and quinine are shown to ... | 1986 | 3012241 |
| purification and characterization of plasmodium berghei dna topoisomerases i and ii: drug action, inhibition of decatenation and relaxation, and stimulation of dna cleavage. | it has recently been suggested that topoisomerases could be important targets for drugs used in several diseases. this prompted us to purify and characterize the topoisomerases i and ii present in the erythrocytes of protozoan parasites of the genus plasmodium, the causative agent of malaria, in order to later use these enzymatic systems in antimalarial drug assays. the topoisomerases were purified from plasmodium berghei, a parasite of mouse red cells. the plasmodium topoisomerase ii consists o ... | 1986 | 3011062 |
| antimalarial agents, 2. artesunate, an inhibitor of cytochrome oxidase activity in plasmodium berghei. | the activity of the cytochrome oxidase, which is located in the plasma and the nuclear and the food-vacuole-limiting membranes as well as in the mitochondria of the trophozoites of plasmodium berghei, was inhibited completely by sodium artesunate, an antimalarial drug, in vitro at 1 mm and in vivo at 100 mg/kg iv. this enzyme appears to be a target for the antimalarial mechanism of action of artesunate and qinghaosu. | 1986 | 3009719 |
| [inhibition of plasmodium berghei in rats infested with strongyloides ratti or trichinella spiralis; role of high blood corticosterone in reaction to the development of helminths]. | the plasma corticosterone induced in the rat by the development of strongyloides ratti or trichinella spiralis reaches a sufficient level of intensity to determine reticulocytopenia. the latter is linked chronologically to the inhibition of parasitemia in plasmodium berghei, which occurs when this protozoa develops at the same time as the nematodes, and seems to be the causal factor. this hypothesis may be verified by replacing the helminths with the corticotropic action of a.c.t.h. which causes ... | 1985 | 3002223 |
| magnetic resonance studies of the pathophysiology of murine malaria. | 1985 | 2999860 | |
| identification of a telomeric dna sequence in plasmodium berghei. | a fragment of plasmodium berghei dna was cloned using a technique designed to select for telomeric sequences. the cloned fragment recognizes bal31-sensitive bands in p. berghei genomic digests. it contains at its distal end at least 70 tandem repeats of the heptanucleotide sequence ccctgaaa. the presence of natural single strand discontinuities in the telomeric regions of p. berghei dna is demonstrated by the selective incorporation of deoxyribonucleoside triphosphates in the absence of dnase. t ... | 1985 | 2998771 |
| screening of morinda lucida leaf extract for antimalarial action on plasmodium berghei berghei in mice. | the leaf extract of morinda lucida collected in august was administered subcutaneously to albino swiss mice infected with p. berghei berghei. the schizontocidal activity on early infection was assessed by administering chloroquine (standard) distilled water or morinda lucida as single daily dose on day 0-3 to infected mice. on day 4 the degree of parasitaemia and percentage was determined in relation to control. its schizontocidal activity was also observed on an established infection by adminis ... | 1985 | 2994441 |
| lack of schizontocidal activity of three herbal decoctions on plasmodium berghei berghei in mice. | this work reports the effects of three herbal decoctions on plasmodium berghei berghei in mice. the schizontocidal activity of each decoction was determined on an established infection using chloroquine as a standard and distilled water as control. also a repository study of the decoction was carried out in another group of mice. the three decoctions neither reduced parasitaemia nor prolonged the life of infected mice that received them. | 1985 | 2994440 |
| effect of azadirachta indica on plasmodium berghei berghei in mice. | azadirachta indica leaf extract has been investigated for antimalarial activity against drug sensitive strain of p. berghei berghei in mice. on administering the extract subcutaneously to infected mice in the "4-day schizontocidal test' 41.2% suppression of parasitaemia was observed. a similar observation was made when the extract was injected for 3 days before the animals were infected with the parasites, 21.7% chemosuppression was obtained. when treatment commenced after the infection had alre ... | 1985 | 2994439 |
| investigations of various extracts of morinda lucida for antimalarial actions on plasmodium berghei berghei in mice. | morinda lucida extracts, the stem bark, the root bark and the leaves were screened for antimalarial activity in a "4-day schizontocidal test' against a chloroquine-sensitive strain of p. berghei berghei in mice. each extract was administered as a single daily dose on days 0, 1, 2 and 3 to mice that had received an intraperitoneal inoculum of 1 x 10(7) infected erythrocytes. each extract produced a degree of suppression of parasitaemia. the most promising result was obtained with chromatographic ... | 1985 | 2994438 |
| plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony. | dl-alpha-difluoromethylornithine and dl-alpha-monofluoromethyldehydroornithine methyl ester, inhibitors of ornithine decarboxylase, blocked exoerythrocytic schizogony of plasmodium berghei in mice and in cultured human hepatoma cells. these effects were reversed by exogenous administration of the polyamine, spermidine. the antimalarial drug, primaquine, the side chain of which is structurally analogous to a natural polyamine, did not enhance the activity of alpha-difluoromethylornithine or alpha ... | 1985 | 2990989 |
| acth-dependent modulation of malaria immunity in mice. | tetracosactrin, a synthetic adrenocorticotrophic hormone (acth) analogue delivered by osmotic minipumps implanted s.c. in mice induced a dose-dependent increase of plasma corticosterone levels. in mice with an established immunity to plasmodium berghei the increase of the plasma corticosterone level due to tetracosactrin treatment correlated with loss of immunity against this malaria parasite. the observed plasma corticosterone levels associated with loss of malaria immunity were of the same ord ... | 1985 | 2987773 |
| in vitro cultivation of the exoerythrocytic stage of plasmodium berghei in irradiated hepatoma cells. | growth of cultures of human hepatoma cells was inhibited by exposure to doses of gamma irradiation as low as 1,000 rad., and the monolayers remained viable for up to 35 days. irradiated cells were at least as susceptible to plasmodium berghei sporozoite invasion as non-irradiated cells, and supported the entire exoerythrocytic cycle producing more infectious merozoites. irradiated cultures may have use for culture of human malarias, and drug studies requiring synchronous cultures. | 1985 | 2982289 |
| immunoradiometric assay to measure the in vitro penetration of sporozoites of malaria parasites into hepatoma cells. | we describe here an immunoradiometric assay to quantitate the in vitro invasion of hepatoma cells by sporozoites. the assay measures levels of circumsporozoite (cs) antigen that remain associated with the hepatoma cells after their incubation with the parasites. several observations show that these measurements reflect internalized rather than extracellular antigen. for example, when incubations were performed with nonviable parasites (sonicated or heated), or in the presence of metabolic inhibi ... | 1985 | 2981261 |
| impairment of t-helper function by a plasmodium berghei-derived immunosuppressive factor. | mice injected with an immunosuppressive factor (isf) extracted from plasmodium berghei-infected rat erythrocytes have a reduced antibody response to unrelated antigens. t-cells from isf-treated mice failed to provide adequate help to naive, syngeneic b-cells in the primary igm response in vitro to sheep red blood cells and to dinitrophenylated keyhole limpet hemocyanin. the same t-cells, however, were able to cooperate with memory b-cells in the secondary igg response. no other cellular deficit ... | 1988 | 2974077 |
| induction of macrophage motility by a t-cell line from balb/c mice specific for plasmodium berghei malaria. | a long-term antimalaria t-cell line (amtl) expressing a helper phenotype (thy 1.2+, lyt 2.2-) was established from plasmodium berghei-recovered balb/c mice. the ability of this t-line to induce macrophage motility was measured in vivo and in vitro. adoptive transfer of amtl cells to normal balb/c mice showed an increased delayed hypersensitivity response to the homologous antigen, i.e., parasitized erythrocytes (pe). in vitro, amtl culture supernatant (amtl-sup) augmented chemotactic locomotion ... | 1988 | 2973521 |
| a kinetic model of phosphofructokinase from plasmodium berghei. influence of atp and fructose-6-phosphate. | phosphofructokinase (pfk) from the malarial parasite plasmodium berghei shows the following kinetic features: the more the ph is decreased, the more the enzyme is inhibited by atp; in contrast to pfk from erythrocytes, this inhibition is less potent by two orders of magnitude; as in the red cell, fructose-6-phosphate (f6p) is a positive effector. kinetic modelling of pfk from p. berghei has been performed by taking the ph-dependence of activity into regard, implicitly by the estimation of ph-dep ... | 1988 | 2963958 |
| manifestation of cerebral malaria-like symptoms in the wm/ms rat infected with plasmodium berghei strain nk65. | conditions required for the induction of cerebral malaria (cm)-like symptoms were investigated using 12 strains of rats and 5 murine malaria strains. among various combinations, only inbred wm/ms rats infected with p. berghei (nk65) developed neuropathological complications that closely resembled human cm cases. when young wm/ms rats were infected with the parasites, neurologic signs were induced followed by death in 5-10 days with almost 100% incidence, whereas aged hosts revealed strong resist ... | 1987 | 2963898 |
| plasmodium berghei: lymphocyte and macrophage dynamics in the spleen of balb/c mice in the course of infection and after rechallenge of cured mice. | the purpose of this study was to determine a possible correlation between the cell populations of the immune system in the spleen, and the failure of normal balb/c mice to overcome a plasmodium berghei infection. after primary infection, all splenic white cell populations increased in number. however, the ratios between the different cell populations changed markedly. macrophages, which comprise 5-10% of normal white spleen cells, rose to 70-80?% during the lethal infection. most of the macropha ... | 1988 | 2962882 |
| [development of a line of plasmodium berghei resistant to sodium artesunate]. | 1987 | 2959002 | |
| interferon-gamma inhibits the intrahepatocytic development of malaria parasites in vitro. | in this study, we examined the activity of recombinant interferon (ifn)-gamma against plasmodium berghei exoerythrocytic forms (eef) grown in vitro within the highly differentiated human hepatoma cell line hepg2. we assayed the effect of ifn-gamma on parasite growth by dna hybridization using a p. berghei specific dna probe. the specific activity of ifn-gamma against eef is very high, and depends upon the time of lymphokine addition. when ifn-gamma is added to hepg2 cells containing intracellula ... | 1987 | 2957445 |
| antimalarial activity of tripynadine in mice and monkeys. | 1987 | 2955662 | |
| [effects of artemether on red blood cell immunity in malaria]. | 1986 | 2954426 | |
| [delay in emergence of resistance to pyronaridine phosphate in plasmodium berghei]. | 1986 | 2954424 | |
| [effects of piperaquine on the fine structure of the erythrocytic stages of plasmodium berghei anka strain]. | 1986 | 2954398 | |
| [effect of pyronaridine on ultrastructure of erythrocytic forms of plasmodium berghei in mice]. | 1985 | 2945375 | |
| [stability of drug resistance of a pyronaridine-resistant line of plasmodium berghei]. | 1985 | 2943123 | |
| surface plasmodium sugar-binding components evidenced by fluorescent neoglycoproteins. | a sugar-binding component was shown to be present at the surface of endoerythrocytic plasmodium berghei and p. chabaudi stages and merozoites by means of a panel of neoglycoproteins using fluorescence microscopy and flow cytofluorometry. the protein nature of this material was ascertained by the loss of sugar-binding capacity upon trypsin treatment. this lectin-like protein primarily bound neoglycoprotein-borne n-acetylglucosamine and secondarily bound neoglycoprotein-borne alpha-d-glucose, beta ... | 1986 | 2941097 |
| [the effect of qinghaosu on the pfc and rfc of mice infected with plasmodium berghei]. | 1985 | 2936520 | |
| [response of the plasmodium berghei anka strain to some antimalarials]. | 1985 | 2934947 | |
| comparison of repeated dna from strains of entamoeba histolytica and other entamoeba. | restriction enzyme digestion patterns of total genomic dna revealed the presence of highly repeated dna in entamoeba histolytica and e. histolytica-like (laredo type) amoebae of humans, e. invadens and e. invadens and e. terrapinae of reptiles, and e. moshkovskii isolated from sewage polluted waters. homology with plasmodium berghei ribosomal dna was striking. northern blot analysis of e. histolytica rna provided further evidence that the highly repeated dna codes for ribosomal rna. the distribu ... | 1988 | 2893976 |
| plasmodium berghei-infected mice: lack of effect of meclizine and cimetidine on the development of pulmonary oedema. | the involvement of histaminergic mechanisms in the pathogenesis of pulmonary oedema observed in plasmodium berghei-infected mice was investigated. histamine concentrations in plasma and whole blood of infected and normal mice were determined by radioenzymatic assay during the seven days of the infection. elevated plasma and whole blood histamine levels were found at the last stages of infection (sixth day and seventh day after ip injection of parasitized erythrocytes), showing a close temporal c ... | 1986 | 2888439 |
| the sustained release of pyrimethamine base or pyrimethamine pamoate from a biodegradable injectable depot preparation in mice. | the pharmacokinetics and mass fate in mice, of pyrimethamine (425 mg kg-1 s.o.) administered subcutaneously either as the base (base) or the pamoate salt (pam) in an injectable oil mixture (benzyl benzoate-peanut oil 50:50 v/v) have been evaluated. maximum measured plasma pyrimethamine levels after base were attained within 24 h, and were twice as high as after pam. 25% of animals dosed with base died; among the survivors plasma drug levels fell rapidly below the minimum inhibitory concentration ... | 1985 | 2868095 |
| in vitro formation of ookinetes and functional maturity of plasmodium berghei gametocytes. | in vitro formation of plasmodium berghei ookinetes was studied. gametocytes produced in vitro were obtained from heart and tail blood of swiss mice and from blood removed from mosquitoes directly after feeding on these mice. in vitro produced gametocytes were obtained from short-term cultures of the erythrocytic stages of p. berghei. reproducible ookinete production was obtained in medium rpmi 1640, ph 7.8-8.0, using in vivo and in vitro produced gametocytes. the morphology of developmental stag ... | 1985 | 2863802 |
| re-examination of earlier work on repetitive dna and mosquito infectivity in rodent malaria. | previous results, relating mosquito infectivity to percentage of repetitive dna in the genome of plasmodia, are re-examined in the light of the finding that a parasite line used in the previous studies and classified as plasmodium berghei nk65, was a mixed infection, where the major component appeared to be plasmodium yoelii. this conclusion was reached through cloning and isoenzyme typing of different clones. isoenzyme typing alone is not sufficiently sensitive to reveal contamination amounting ... | 1985 | 2863751 |
| c3b inactivator in normal mice and mice infected with plasmodium berghei berghei. | c3b inactivator levels were assayed in clean albino mice and mice infected with plasmodium berghei berghei. infected animals (63.1%) had low c3b inactivator levels when compared with 45% of controls with low levels. in the low titre range, infected mice had a significantly lower mean level (p less than 0.001) of the factor than controls. conversely, in the high titre range, the mean c3b inactivator level is significantly (p less than 0.001) higher in infected than in control mice. lower levels o ... | 1988 | 2845758 |
| primary sequences of two small subunit ribosomal rna genes from plasmodium falciparum. | we have determined the complete sequence of two structurally distinct 18s ribosomal rna genes from the malarial parasite plasmodium falciparum. s1 nuclease analyses demonstrate that only one of the genes is represented in stable rrna populations isolated from blood-stage parasites. comparisons of homologous rrna genes from plasmodium berghei and p. falciparum reveal that they are identical at 86% of their positions. from comparisons of the plasmodium genes to that of humans, it was possible to d ... | 1988 | 2836731 |
| effect of solanum erianthum aqueous leaf extract on plasmodium berghei in mice. | the aqueous leaf extract of solanum erianthum collected in may was administered orally to albino swiss mice infected with plasmodium berghei berghei. the schizontocidal activity on early infection was assessed by administering the extract of s. erianthum, chloroquine, or distilled water as single daily dose from the day of infection for 4 days. microscopic examination made on the fifth day from all the mice, showed s. erianthum extract producing a dose-related schizontocidal effect, with the hig ... | 1987 | 2830780 |
| fractionation of mouse malarious blood according to parasite developmental stage, using a percoll-sorbitol gradient. | asexual intraerythrocytic malarial parasites permeabilize the membrane of their host cell to small monelectrolytes and anions. since permeabilization increases with parasite maturation, this property has been used previously to fractionate blood infected with plasmodium falciparum and p. knowlesi according to the developmental stage of the parasite, using percoll-sorbitol density gradients. we have extended this method to fractionate mouse blood infected with four species of rodent malaria: p. c ... | 1987 | 2827557 |
| tricyclic 2,4-diaminopyrimidines with broad antifolate activity and the ability to inhibit pneumocystis carinii growth in cultured human lung fibroblasts in the presence of leucovorin. | a selected number of 1,3-diaminobenzo[f]quinazolines and 1,3-diamino-5,6-dihydrobenzo[f]quinazolines, which may be viewed as tricyclic analogues of the lipid-soluble antifolates pyrimethamine (pm), metoprine (ddmp), and etoprine (ddep), were tested as inhibitors of purified dihydrofolate reductase (dhfr) from wi-l2 lymphoblasts, and as inhibitors of the growth of streptococcus faecium atcc 8043 and l1210 murine leukemia cells in culture. in addition, these tricyclic compounds were tested for ant ... | 1989 | 2788420 |
| spectrum of the antimalarial activity of a new macrolide antibiotic midecamycin in mice and monkeys. | the antimalarial activity of a new macrolide antibiotic, midecamycin, has been evaluated against a sensitive strain of plasmodium berghei, a chloroquine-resistant strain of p. yoelii nigeriensis and a simian parasite, p. cynomolgi b. the ed50 and ed90 values of this antibiotic administered in two divided daily doses were found to be 37.15 +/- 3.51 and 100.84 +/- 7.54 mg/kg, respectively, against p. berghei and 362.34 +/- 85.33 and 878.04 +/- 10.02 mg/kg, respectively, against p. yoelii nigeriens ... | 1989 | 2766859 |
| effects of pyran copolymer on host resistance of mice to plasmodium yoelii. | female b6c3f1 mice treated with 25 mg/kg pyran intravenously (i.v.) on days -4 and -3 were more susceptible to nonlethal plasmodium yoelii 17xnl or lethal plasmodium berghei atcc-30090 than untreated mice or mice treated intraperitoneally (i.p.). female b6c3f1 mice treated with pyran i.p. displayed enhanced resistance to listeria monocytogenes as compared to untreated mice or mice given pyran i.v. peritoneal exudate cells (pec) primed by pyran i.p. possessed enhanced ability to kill listeria but ... | 1989 | 2723926 |
| tumor necrosis factor alpha and the anemia associated with murine malaria. | the anemia associated with malaria is complex, and multiple factors contribute to its severity. an increased destruction and a decreased production of erythrocytes are involved; however, the mechanisms responsible remain unclear. tumor necrosis factor alpha (tnf-alpha), released by macrophages in response to infection, is thought to play a role through its ability to inhibit erythropoiesis. in these studies we have examined erythropoiesis in mice infected with plasmodium berghei and in mice infu ... | 1989 | 2707858 |
| characterization of a model of malaria in the pregnant host: plasmodium berghei in the white rat. | this study characterizes a plasmodium berghei white rat model of p. falciparum malaria in the pregnant human. seventy-day-old and 114-day-old female rats, given an infecting inoculum at time of mating, had higher parasitemias and a more severe anemia than age- and sex-matched controls. under these experimental conditions, the parasitemia went to crisis in all animals and there were no fatal infections. in contrast, all animals died when the infection was initiated 7 days after conception, a timi ... | 1989 | 2701632 |
| [synthesis and antimalarial as well as antitumor activities of 1-methyl-2,4-diamino-6-(n-methyl-substituted benzylamion) quinazolinium iodides]. | fourteen 1-methyl-2,4-diamino-6-(n-methyl-substituted benzylamino) quinazolinium iodides (ii) were synthesized by treatment of 2,4-diamino-6-substituted benzylaminoquinazolines with methyl iodide. three compounds (ii4,7,10) were shown to produce 100% suppression on plasmodium berghei in mice at oral dose of 20 mg/kg and ii4 was found to inhibit twice as much as methotrexate on l1210 leukemia cells in culture. | 1989 | 2700414 |
| ultrastructural comparison of erythrocytic stages of experimentally selected drug resistant strains of rodent malaria parasite p. berghei with its susceptible strain. | studies on ultrastructure of drug-resistant strains of plasmodium berghei have been mostly restricted to the experimentally selected chloroquine and pyrimethamine resistant strains. study of the morphology of mefloquine and quinine resistant strain of p. berghei has been carried out to demonstrate some differences between normal and drug-resistant strains. the main differences are concerned with a complex physiological process i.e., food ingestion and digestion. e.m. studies reveal that in the s ... | 1989 | 2699865 |
| the antioxidants as protectors of host stress organ injury in mice infected with plasmodium berghei. | a study has been made of counteracting the stress organ injury in plasmodium infection by means of antioxidants on the premise that free radicals are responsible for causing the injury to stress organs. this was evidenced by drastically altered biochemical parameters in liver and spleen of the host in terms of elevated levels of lipid peroxides and xanthine oxidase (xo) activity, and a fall in superoxide dismutase activity coupled with other drastic biochemical changes. the cardinal factor respo ... | 1989 | 2699864 |
| in vitro culture of erythrocytic stages, including gametocytes of plasmodium berghei (nk 65 strain) using candle jar method and a newly designed continuous medium flow apparatus. | three methods have been described for cultivation of erythrocytic stages, specially gametocytes of p. berghei nk65 strain, (1) by using vial candle jar where the cultures were subcultured by addition of fresh erythrocytes, (2) a newly designed simple and compact continuous medium flow apparatus, where medium was continuously perfused but fresh erythrocytes were not added and (3) where the subcultures were also done using simple and compact continuous medium flow apparatus for comparison. the max ... | 1989 | 2699308 |
| evaluation of ciep and elisa in a rodent malaria model. | circulating antigens could be detected by both elisa and ciep in the sera of mice infected with plasmodium berghei. however, elisa was positive for circulating antigen even though the giemsa stained smears did not show significant parasites. hence, elisa can have a diagnostic value for detection of antigens as a marker of active infection. | 1989 | 2698862 |
| hepatic low density lipoprotein receptor binding and lipid profile in mastomys natalensis during plasmodium berghei infection. | plasmodium berghei infection to mastomys natalensis showed hyper beta-lipoproteinemia. the increase in serum cholesterol is associated with decreased uptake of low density lipoprotein (ldl) by the liver through receptor mediated endocytosis. the membranes prepared from infected m. natalensis exhibit up to 50% decline in high affinity binding sites for human 125i-ldl. significant increases in serum lipids, cholesterol, triglyceride and lipid peroxide (lpo) contents of liver membrane were observed ... | 1989 | 2698856 |
| benzoxazinone derivatives: new fluorescent probes for two-color flow cytometry analysis using one excitation wavelength. | a new class of fluorescent dye which upon excitation at 488 nm turns red is shown to be probe-suitable for using in flow cytometry alone or in conjunction with fluorescein derivatives. 7-dimethylamino 3-(p-formylstyryl) 1,4 benzoxazin 2-one is suitable for rendering microorganisms, such as plasmodium merozoites and cells detectable by flow cytometry, allowing a dual fluorescence analysis when the cells are labelled with suitable fluoresceinylated ligands such as fluorescein labeled neoglycoprote ... | 1989 | 2698760 |
| hepatoprotective activity of silymarin against hepatic damage in mastomys natalensis infected with plasmodium berghei. | silymarin, a flavolignan from the seeds of silybum marianum, showed significant hepatoprotective activity in p. berghei-induced hepatic damage in m. natalensis, as assessed by changes in several serum and liver biochemical parameters. changes in lipoprotein-x, got, gpt, alkaline phosphatase and bilirubin were found to be protected by silymarin at different doses. maximum activity was observed at a dose of 5 mg/kg bw, po. silymarin had no effect on parasitaemia. | 1989 | 2697691 |
| [complete inhibition of cyclic transmission by immunization against plasmodium berghei anka ookinetes]. | an antiserum raised against p. berghei anka ookinetes binds specifically to ookinetes and zygotes surface as assessed by indirect immunofluorescence. the transmission blocking activity of this serum was assessed by feeding mosquitoes on immunized mice. a serum showing an antibody titer of 1/320 reached after 6 immunizations completely blocks ookinetes development. this immune serum might be used to screen p. berghei genomic or cdna library in order to identify or clone sequences involved in the ... | 1989 | 2696409 |
| cerebral lesions in mice infected with plasmodium berghei are the result of an immunopathological reaction. | cerebral lesions in mice with plasmodium berghei infections can be prevented by timely treatment with immune serum, by splenectomy, and by administration of dexamethasone. t cell deficient mice do not develop cerebral lesions. the results of these studies are compatible with the hypothesis that a pathological reaction is responsible for development of cerebral lesions in mice infected with p. berghei. | 1989 | 2696153 |
| plasmodium falciparum ookinetes migrate intercellularly through anopheles stephensi midgut epithelium. | the migration of plasmodium falciparum and p. berghei ookinetes through the midgut epithelium in anopheles stephensi was studied by transmission electron microscopy. with ruthenium red (rr) staining, the results of previous studies were confirmed: p. falciparum ookinetes take an intercellular route through the midgut epithelium. in the same mosquito species, the rodent parasite p. berghei appeared to take an intracellular position, as previously suggested by other authors. the intra- or intercel ... | 1989 | 2695921 |
| interactions between vitamin a deficiency and plasmodium berghei infection in the rat. | it has been claimed that vitamin a deficiency increases the severity of malarial infection in rats. we measured parasitemia, mortality, serum retinol, liver retinol, spleen weight, and degree of xerophthalmia in vitamin a-deficient rats (a-), pair-fed control rats (a+pf), and ad libitum-fed control rats (a+al) infected with plasmodium berghei, a rodent malarial parasite. in experiments 1 and 2 vitamin a deprivation began at weaning. parasitemia and mortality among mildly deficient (expt. 1, mean ... | 1989 | 2695606 |
| immunoprotection by beta-1,3 glucan antigen combination in plasmodium berghei infection in mice. | in an attempt to protect mice against experimental infection with p. berghei, mice were immunized against soluble extract of p. berghei in combination with beta-1,3 glucan or fca and also independently. mice immunized against p. berghei antigen-glucan developed well defined cell mediated and humoral immune responses, while mice injected with antigen fca or antigen alone developed only an antibody response. antigen-glucan immunization afforded a high degree of immune protection to the host agains ... | 1989 | 2695459 |
| [synthesis and antimalarial and antineoplastic activities of some derivatives of 2,4-diamino-5-methyl-6-substituted benzylaminoquinazolines]. | this paper reports the synthesis and the antimalarial and anticancer activities of some derivatives of 2,4-diamino-5-methyl-6-substituted benzylaminoquinazolines. these compounds were synthesized by condensation of 5-methyl-2,4,6-triaminoquinazoline with substituted benzyaldehyde to produce schiff base, followed by reduction, formylation or nitrosation. the suppressive therapeutic effects against plasmodium berghei in mice showed that the suppressive rate of three compounds (iv 2,5,6)was 100 per ... | 1989 | 2694758 |
| [pharmacodynamics of dihydroartemisinine against plasmodium berghei in mice]. | dihydroartemisinine (dha) is a derivative of qinghaosu(artemisine), which is an antimalarial drug. dha was given to mice inoculated with plasmodium berhgei anka strain by intramuscular injection. within proper dose range, the dose-effect and time-effect curves of dha against the malaria can be described by y = 4.9960 + 2.9536 x and y = 7.2654 - 0.3414 t, respectively, where y is the estimated value of parasitemia suppressing rate in probit; x is log dose; t is the period since drug administratio ... | 1989 | 2694757 |
| antiplasmodial activity of an aqueous infusion prepared from brucea javanica fruits against plasmodium falciparum and p. berghei. laboratory meeting, london school of hygiene and tropical medicine. 17 november 1988. abstracts. | 1989 | 2694473 | |
| significance of blood urea nitrogen as an index of renal function in mice infected with plasmodium berghei. | parameters of renal function were evaluated in severe malarial infection, using mice infected with plasmodium berghei. when 7-week-old male balb/c mice were inoculated with 1 x 10(7) p. berghei nk65-infected red blood cells, the rodents died an average of 7.4 days after inoculation. anemia developed on day 5 after inoculation and progressed markedly on days 6 and 7. plasma urea nitrogen increased rapidly on day 6 or 7, after which death occurred within 24 h. in contrast, urinary urea nitrogen ex ... | 1989 | 2694168 |
| presence of contaminating mitochondrial dna from host reticulocytes in experimental infections of plasmodium berghei. | superposition of two unrelated processes, namely terminal reticulocyte differentiation and synchronous plasmodial development, takes place in experimental infections of plasmodium berghei. the first process is shown to be responsible for the appearance of some discrete restriction bands of host origin when dna is extracted from leucocyte-free blood containing synchronous parasites at early stages of infection. these discrete dna fragments cross-hybridize with host cell mitochondrial dna. purific ... | 1989 | 2693960 |
| changing pattern of antimalarial drug resistance. | with the current increase of international travel and increasing drug resistance, united kingdom residents stand a high risk of contracting malaria when they visit endemic countries. the development of anti-malarial agents from old traditional plant remedies to modern synthetic drugs is briefly reviewed. resistance to the latter has spread rapidly since the 1950s, culminating in the widespread distribution of multiple drug-resistant strains of plasmodium falciparum in most endemic areas. there i ... | 1989 | 2693718 |
| [the in-vitro action of chloroquine on the infectivity of gametocytes of plasmodium berghei anka]. | the influence of chloroquine on the infectivity of gametocytes of p. berghei anka chloroquino-sensitive was assessed in vitro. it was found that chloroquine could not affect the exflagellation of microgametocytes but prevented the formation of ookinetes at the concentration of 10 micrograms/ml. this activity seemed to be stage and dose dependent. | 1989 | 2692524 |
| antagonism of serum of mice infected with chloroquine-resistant 'ns' line to the antimalarial action of chloroquine. | chloroquine (cq) solution was separately mixed with the serum of mice infected with chloroquine-resistant 'ns' line (smns), the serum of mice infected with chloroquine-sensitive plasmodium berghei anka strain (smcs), and the serum of normal mice (sm). these mixtures were then used in treating mice inoculated with p. berghei anka strain. the results obtained on d 5 after drug-serum administration showed that the erythrocyte infection rates in the smns + cq, smcs + cq, and sm + cq groups were 32, ... | 1989 | 2692400 |
| antimalarial and toxic effect of triple combination of pyronaridine, sulfadoxine and pyrimethamine. | the triple combination of pyronaridine, sulfadoxine and pyrimethamine which has been proven to be efficient in delaying emergence of drug resistance of rodent malarial parasites was further studied for potential application to malaria control. the antimalarial effect of the triple combination on plasmodium berghei anka-infected mice and the toxic effects in mice and rats were additive. a single dose of pyronaridine 500 mg in combination with sulfadoxine, 1000 or 1500 mg, and pyrimethamine, 50 or ... | 1989 | 2692191 |
| an in vivo study on the effect of the immunosuppressant drug cyclosporin in malaria-infected mice. | 1989 | 2690419 | |
| the chemotherapy of rodent malaria. xliv. studies on the mode of action of cm 6606, an indolo (3,2-c) quinoline n-oxide. | cm 6606 differs in its mode of action from chloroquine but studies on its activity against parasites resistant to other antimalarials suggest that it may have some features in common with aminoalcohols. similarities in drug-induced pigment changes are especially striking. only halofantrine shows a reduced activity, however, against parasites that are highly resistant to cm 6606, while such parasites are slightly hypersensitive to sulfadoxine and clindamycin. evidence suggesting that cm 6606 may ... | 1989 | 2688575 |
| contrasts in antigen expression in the erythrocytic and exoerythrocytic stages of rodent malaria. | the time and site of expression of five antigens, recognized by monoclonal antibodies raised against blood-stage parasites, were studied in the exoerythrocytic stage of plasmodium berghei using indirect immunofluorescent antibody staining. two monoclonal antibodies (w 3.5, i 2.6), which stain the cytoplasm of infected erythrocytes, did not stain the cytoplasm of the infected liver cell but stained the parasite itself suggesting a difference in the antigenic architecture of the erythrocytic and e ... | 1989 | 2687775 |
| studies on 2,3,n,n'-substituted 4,4'-diaminodiphenylsulfones as potential antimalarial agents. | a series of new 4,4'-diaminodiphenylsulfones substituted at 2 and 3 position and also at primary amino group of the phenyl rings have been synthesized and evaluated for their antimalarial activity against plasmodium berghei infection in mice. some of these compounds were active and showed complete inhibition of parasitaemia which included 7a1-7a4, 7b3, 7b4 and 16a at 1 mg/kg i.p. for 4 days and 16a, at 0.3 mg/kg for 4 days. some compounds tested for their synthetase inhibitory action in cell-fre ... | 1989 | 2686657 |
| preparation and biological activity of new substituted antimalarial diaminodiphenylsulfones. | starting from 4,4'-diamino-diphenylsulfone (dds) as a lead structure, new 2-substituted analogues as well as new 2-substituted 4-alkylamino-4'-amino diphenylsulfones have been designed and synthetized in different ways. this has led to compounds the inhibitory activity of which against 7,8-dihydropteroic acid synthase of plasmodia and mycobacteria is clearly superior to that of sulfadoxine and in most cases to that of dds. of special interest is 4'-amino-4-n-propylamino-2-methyl-diphenylsulfone. ... | 1989 | 2686656 |
| estimating the degree of infection of plasmodium berghei infected red blood cells by evaluation of pyruvate kinase activity. | a procedure is proposed to estimate the parasitemia of red blood cells infected with p. berghei by determination of pyruvate kinase activity. the activity of this enzyme shows a linear dependence not on the relative number of infected cells but on the average number of parasites per red blood cell. to provide a transformation between these two parameters a theoretical model of multiple infections of blood cells is derived, the accuracy of which was proved experimentally. | 1989 | 2684475 |
| [antimalarial action of alloxan and 5,6-diamino-2,4-dihydroxy-pyrimidine in plasmodium berghei]. | three hours after iv administration of alloxan and 5,6-diamino-2,4-dihydroxy-pyrimidine to mice infected with chloroquine-sensitive (cs) and chloroquine-resistant (cr) strains of plasmodium berghei, the 2 compounds showed remarkable antimalarial actions. parasitemia in cs and cr infected mice were reduced by about 50%. slight hemolysis was seen in mice treated with alloxan but not in mice treated with 5,6-diamino-2,4-dihydro-pyrimidine. alloxan did not inhibit glutathione reductase activity and ... | 1989 | 2683580 |
| chloroquine blood levels after administration of the liposome-encapsulated drug in relation to therapy of murine malaria. | in a previous report (p. a. m. peeters, c. w. e. m. huiskamp, w. m. c. eling, and d. j. a. crommelin. parasitology, 1989, in press) an increase in therapeutic and prophylactic potential was found when chloroquine (cq) was encapsulated in fluid-state liposomes (lipcq) and tested in plasmodium berghei-infected mice in comparison to intraperitoneal (i.p.) administration of the free drug. in this study, the same model was used to demonstrate that encapsulation of cq into gel-state liposomes further ... | 1989 | 2682591 |
| [mechanism of porphyrin conformational changes of hemoglobin in the blood in malarial infestation]. | the reversible conformational changes in porphirine of hemoglobin of mouse blood during malaria and under laser and tocopherol effects were studied by means of raman spectroscopy. | 1989 | 2682477 |
| ontogeny of ookinete of plasmodium berghei (nk 65): a scanning electron microscopic study. | the ontogeny of ookinete of plasmodium berghei (nk 65) was studied in vector anopheles stephensi fed on infected mastomys natalensis. the round zygote transformed into an ookinete after passing through following stages-1 gram-seed shaped zygote, 2 comma-shaped stage, 3 semilunar and 4 banana shaped ookinete. each fully formed ookinete had a 'conule' at the anterior end of the body. in some ookinetes under sem a depression was observed in the posterior half of the body. the function of the depres ... | 1989 | 2681394 |
| gametocytocidal and sporontocidal activity of some standard antimalarials on p. berghei (nk 65) infection m. natalensis. | three standard antimalarials pyrimethamine, primaquine and quinine were tested against p. berghei (nk 65) for gametocytocidal and sporontocidal action. pyrimethamine at 7.5, 3.25, 2.5 and 1.25 mg/kg., primaquine at 15, 10 and 7.5 mg/kg, quinine at 225, 168.5, 140.62 and 112.5 mg/kg were given orally to infected m. natalensis for 3 consecutive days i.e., day 6, 7 and 8 post inoculation of sporozoites. to assess sporontocidal action batches of mosquitoes (a. stephensi) were fed on infected-treated ... | 1989 | 2680637 |
| [effect of murine malarial circulating immune complexes on the production of reactive oxygen species by peritoneal exudate cells of normal mice]. | circulating immune complexes (cic) isolated from sera of mice infected with plasmodium berghei by precipitation with polyethylene glycol were examined for their ability to stimulate the production of reactive oxygen species by peritoneal exudate (pec) of normal mice, using luminol-aided chemiluminescence (cl). cic were found to be capable of stimulating the production of cl by normal mouse pec. weaker cl responses were observed when pec were incubated with p. berghei soluble antigens. normal mou ... | 1989 | 2680155 |
| [synthesis and antimalarial as well as antitumor activities of 2,4-diamino-6-(n-methyl-substituted benzylamino) quinazolines]. | sixteen 2,4-diamino-6-(n-methyl-substituted benzylamino) quinazolines (i) were synthesized by two different methods. 2-nitro-5-chloro-benzonitrile was treated with the appropriate n-methyl-substituted benzylamines and i was formed after reduction and cyclization. another method was reductive methylation, i.e., 2,4-diamino-6-substituted benzylaminoquinazolines reacted with formaldehyde and sodium cyanoborohydride at ph 6.3. suppressive therapeutic tests in mice infected with plasmodium berghei sh ... | 1989 | 2678893 |
| cultivation of the exoerythrocytic stage of plasmodium berghei in primary cultures of mouse hepatocytes and continuous mouse cell lines. | plasmodium berghei exoerythrocytic (ee) stages have been cultured in vitro in human continuous cell lines and primary cultures of both human and rat hepatocytes. although the predominant experimental model of irradiated sporozoite-induced protective immunity is the mouse, p. berghei has not been cultivated in primary mouse hepatocytes or in continuous mouse lines. because of this, target cells are not available for determining if these immunized mice produce cytotoxic t lymphocytes (ctls) that r ... | 1989 | 2676959 |
| effects of malaria on o2 consumption and brown adipose tissue activity in mice. | increased energy expenditure often occurs during illness or after injection of endotoxin and can contribute to the generation of fever. in laboratory rats and mice the thermogenic response has been attributed to the sympathetic activation of brown adipose tissue (bat), although mice often fail to show pyrexia. in this study the effects of malaria on o2 consumption and bat were studied in mice inoculated with plasmodium berghei. parasitemia was maximal (greater than 50% of erythrocytes showing po ... | 1989 | 2676949 |
| protective and pathological activity in serum of mice developing resistance to plasmodium berghei infection. | the serum from mice developing resistance against plasmodium berghei infection using chemotherapeutic treatment has been analysed in vivo and in vitro. during the immunization period pathological as well as protective activities which could be transferred by serum were generated. the pathological activity, which was defined as destruction of erythrocytes in normal recipient mice, was generated early in the immunization procedure, peaked at day 21, and decreased to undetectable levels by day 35. ... | 1989 | 2674863 |
| induction of tnf in vitro as a model for the identification of toxic malaria antigens. | tumour necrosis factor (tnf) has been implicated as a mediator of toxicity in a number of infectious diseases, including malaria. we have shown that human and rodent blood-stage parasites liberate heat-stable soluble antigens that induce the release of tnf by activated macrophages in vitro and in vivo, and are toxic to mice made hypersensitive to tnf by d-galactosamine. these antigens induce t-independent antibodies which specifically block their ability, but not that of bacterial lipopolysaccha ... | 1989 | 2674557 |
| host cell specificity and schizogony of plasmodium berghei under different in vitro conditions. | invasion and intra-erythrocytic growth of two strains of plasmodium berghei (anka and k173) were studied under different in vitro conditions. some important limiting factors for the mass cultivation of this rodent malaria parasite were reconsidered. parasites of both strains developed normally from ringforms into mature schizonts in rpmi1640 supplemented with fetal calf serum (fcs). at a temperature of 37 degrees c the duration of the schizogonic cycle was comparable to that of the same parasite ... | 1989 | 2674047 |
| peroxides as oxidant antimalarials. | to further explore the antimalarial activity of peroxides (e.g. artemisinin 1), twenty-three peroxides (all the compounds shown in figures 3 and 4) of diverse chemical structure and acceptable stability were selected and tested for antimalarial activity in vitro against plasmodium falciparum, and in mice against p. berghei. included were hydroperoxides, dialkyl peroxides, acyl and diacylperoxides, peroxyketals, peroxycarbonates, and endoperoxides. none was active in vivo, although several were r ... | 1989 | 2673281 |
| antimalarial activity of new floxacrine-related acridinedione derivatives: studies on blood schizontocidal action of potential candidates against p. berghei in mice and p. falciparum in vivo and in vitro. | deoxyfloxacrine derivatives (1-hydrazone: s 83 0083; 1-imine: s 84 7277) and floxacrine derivatives (10-methoxy-floxacrine: l 84 7667; 1-imine: l 84 7693) selected from a series of newly synthesized 3-aryl-7-chloro-3,4-dihydro-1,9(2h,10h)-acridinediones were evaluated for blood schizontocidal activities in mice infected with asexual stages of various drug-resistant lines of p. berghei and in new world monkeys infected with blood schizonts of different chloroquine-resistant strains of p. falcipar ... | 1989 | 2671988 |
| acquirement of protective immunity in mice through infection with an attenuated isolate and its failure in parent virulent plasmodium berghei. | in virulent plasmodium berghei infection, mice showed suppressive responses to sheep red blood cells srbc (pfc) as well as the parasite antigen (dth) and developed autoantibodies against homologous lymphocytes. on the other hand, mice infected with an attenuated variant derived from p. berghei did not show these responses but developed solid protective immunity against parent parasite infection accompanied by high antibody titre. when such an immune serum was transferred into mice, attenuated pa ... | 1989 | 2671987 |
| effects of testosterone on blood leukocytes in plasmodium berghei-infected mice. | gonadectomized male mice aged 5 weeks were given 5 mg testosterone propionate daily for 14 days. the treatment significantly decreased the number of blood leukocytes. the number of all individual types of leukocytes except basophils in vehicle-treated gonadectomized mice was increased. testosterone-treated mice consistently had a lower number of leukocytes after being infected with plasmodium berghei than did vehicle-treated mice. the results suggest that testosterone suppresses the production o ... | 1989 | 2671986 |
| comparative morphology of human and animal malaria parasites. i. host-parasite interface. | human and animal malaria parasites (plasmodium falciparum, p. malariae, p. vivax, p. berghei, p. gallinaceum) were studied using special fixation and standardized methods, with special attention to their effects on host cells. morphological alterations induced by the parasites in infected erythrocytes included knobs, invaginations, and caveola-vesicle complexes on the surface of the host cell and clefts, microvesicles, and small vesicles in the cytoplasm of the infected erythrocytes. for p. mala ... | 1989 | 2671984 |
| chloroquine containing liposomes in the chemotherapy of murine malaria. | in this study, the advantage of the use of chloroquine (cq) containing liposomes (lipcq) over free cq in the chemotherapy of murine malaria (plasmodium berghei) was demonstrated. the maximum permissible dose per intraperitoneal injection was 0.8 and 10 mg for cq and lipcq, respectively. an increase in therapeutic and prophylactic efficacy of lipcq in comparison with free cq at a 0.8 mg cq dose level was found. it was possible to obtain 100% efficacy (injection at day 5 after infection; parasitae ... | 1989 | 2671876 |
| modulation of the host's immune response to plasmodium berghei by a parasite-derived immunosuppressive factor. | it is well known that plasmodium-infected hosts are immunosuppressed, as show by their depressed immune responsiveness to a variety of antigens. it is not known, however, whether the immune response of malaria-infected animals to the malarial parasite itself is suppressed. the availability of a noninfectious, immunosuppressive factor (isf) derived from plasmodium berghei-infected rat erythrocytes made it possible to investigate this question. mice infected with p. berghei and injected with the i ... | 1989 | 2671343 |
| antioxidants can prevent cerebral malaria in plasmodium berghei-infected mice. | a/j and cba/h mice infected with plasmodium berghei anka, a murine model of cerebral malaria, were used to see whether antioxidants influenced the outcome of this disease. untreated, infected mice died 7 to 9 days after infection, often with cerebral symptoms. haemorrhages, mononuclear infiltration and oedema were present in the central nervous system (cns). feeding a diet containing 0.75% (w/w) butylated hydroxyanisole (bha) greatly altered the course of this disease. death was delayed by up to ... | 1989 | 2669924 |
| expression of plasmodium berghei circumsporozoite antigen on the surface of exoerythrocytic schizonts and merozoites. | the intracellular distribution of circumsporozoite (cs) antigen was traced by immunoelectron microscopy in cultures of plasmodium berghei exoerythrocytic (ee) schizonts with monoclonal antibody (mab) 3d11 to the immunodominant repeat region of the p. berghei cs protein. cs antigen was localized on the parasitophorous vacuole (pv) membrane and pellicular complex of recently invaded sporozoites and on electron-dense masses of sloughed cs antigen in the host cell cytoplasm. cs antigen persisted thr ... | 1989 | 2669544 |
| host diet in experimental rodent malaria: a variable which can compromise experimental design and interpretation. | over the past few years several experienced groups studying malaria have encountered significant problems with their particular rodent malaria-host system. this has involved, in some cases, periods during which the recovery of cryopreserved parasite stocks and growth of bloodstream parasites was markedly inhibited and, in other cases, periods of drastically increased mortality rates. the common factor linking these incidents was that they coincided with alterations in the experimental animal die ... | 1989 | 2668862 |
| interactions of plasmodium berghei sporozoites and murine kupffer cells in vitro. | malaria sporozoites must leave the bloodstream and cross a layer of sinusoidal lining cells in order to infect hepatocytes and undergo exoerythrocytic schizogony. to determine whether kupffer cells (kc) derived from this layer interact with sporozoites, murine kc were isolated from perfused livers of balb/cj mice and incubated in vitro with plasmodium berghei sporozoites. isolated kc had characteristic macrophage surface ag and were phagocytic, ingesting both latex particles and leishmania major ... | 1989 | 2668413 |
| antimalarials. 16. synthesis of 2-substituted analogues of 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3- (trifluoromethyl)phenoxy]quinoline as candidate antimalarials. | a series of 2-substituted analogues of the exceptional drug 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3- (trifluoromethyl)phenoxy]quinoline (i) were prepared and evaluated for both suppressive and prophylactic antimalarial activity. the preparation of analogues of compound i was of interest due to the high level of both blood and tissue schizonticidal activity demonstrated by this compound. one analogue, 8a, was found to be both more active and less toxic than the parent compound i. ... | 1989 | 2666665 |