Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| effect of t-cell transfer on pneumocystis carinii infection in nude mice. | the effect of transfer of spleen lymphocytes from euthymic heterozygote littermates (nu/+) or rabbit antiserum on pneumocystis carinii (p. carinii) infection in nude (nu/nu) mice was investigated. after intravenous administration of nu/+ spleen t-cells, the number of cysts in the lung of previously infected mice was markedly decreased at day 14 and further at day 30. intense cellular reactions were seen at day 14 and subsided lesions at day 30. increased igg antibody titers were observed at days ... | 1984 | 6332219 |
| acquired immune deficiency syndrome (aids). light microscopic, ultrastructural and immunocytochemical studies of one case. | the lung and axillary lymph node biopsies of a 33-year-old male drug-abuser with clinical and immunologic evidences of aids were studied by light and electron microscopy. encysted pneumocystis carinii organisms with attached membranous expansions and virus-like particles were demonstrated in the alveolar spaces and, occasionally, in macrophages. the lymph node biopsy revealed areas of angioimmunoblastic proliferation associated with lymphocytic depletion of the interfollicular zones. tubuloretic ... | 1984 | 6332199 |
| pneumocystis carinii pneumonia: a problem revisited. | 1984 | 6332188 | |
| five-year absence of pneumocystis carinii pneumonitis in a pediatric oncology center. | 1984 | 6332155 | |
| rapidly progressing rheumatoid arthritis: an example of polyclonal b-cell activation? | we report the case of a 76-year old woman who presented with a palindromic onset of seropositive rheumatoid arthritis. after suffering from a fulminant pulmonary infection she developed serologic tests for ornitosis, mycoplasma, pneumocystis carinii and low titer yersinia. also the rheumatoid factor titer increased and the antinuclear antibody test became positive. clinically, the course of a rather benign polyarthritis changed into a rapidly progressive deforming disease. the course was also co ... | 1984 | 6331972 |
| opportunistic infections in endogenous cushing's syndrome. | the cases of 6 patients with endogenous cushing's syndrome and opportunistic infections were studied, and compared with those of 17 similar patients reported in the literature. cushing's syndrome was caused by ectopic adrenocorticotrophic hormone production or adrenal tumors in most patients, and hypercortisolism was extreme. four infectious processes were preponderant: cryptococcosis, aspergillosis, nocardiosis, or pneumocystis carinii pneumonia occurred in 21 patients. signs and symptoms of in ... | 1984 | 6331781 |
| [autopsy case of adult t-cell leukemia complicated with pneumocystis carinii pneumonia and generalized cytomegalic inclusion body disease]. | 1983 | 6328087 | |
| murine cytomegalovirus and pneumocystis carinii. | 1984 | 6327837 | |
| acquired immune deficiency syndrome: postmortem findings. | the autopsies of 13 male homosexuals with acquired immune deficiency syndrome (aids) were reviewed. all patients had laboratory evidence of cellular immune dysfunction. the most common diagnoses made were disseminated cytomegalovirus infection in 12 patients and kaposi's sarcoma in 10. all patients infected with cytomegalovirus had pulmonary compromise. the adrenal glands and gastrointestinal tract also were involved often by cytomegalovirus. cytomegalovirus infection of organs uncommonly affect ... | 1984 | 6326563 |
| opportunistic infection complicating acquired immune deficiency syndrome. clinical features of 25 cases. | twenty-five cases of acquired immune deficiency syndrome (aids) complicated by opportunistic infections were diagnosed at lenox hill hospital during an 18 month period and followed for at least 1 year or until the patients' deaths. twenty-three patients were homosexual men, including 1 i.v. drug user, and 2 were heterosexual i.v. drug users, including the sole woman. seventy infections were diagnosed. the commonest etiologic agents included candida albicans, pneumocystis carinii, cytomegalovirus ... | 1984 | 6325849 |
| coccidioidomycosis in acquired immune deficiency syndrome. depressed humoral as well as cellular immunity. | progressive pulmonary coccidioidomycosis has not been previously reported in the setting of acquired immune deficiency syndrome (aids). a patient with aids, progressive pulmonary coccidioidomycosis, pneumocystis carinii pneumonia, and disseminated cytomegalovirus is described. diagnosis of these opportunistic pathogens was made by bronchoalveolar lavage and transbronchial lung biopsy. results of traditional complement fixation serologic testing for cytomegalovirus were negative; however, the mor ... | 1984 | 6324591 |
| pneumocystis carinii: oxygen uptake, antioxidant enzymes, and susceptibility to oxygen-mediated damage. | the ability of pneumocystis carinii obtained by alveolar lavage of rats with glucocorticoid-induced pneumocystosis to utilize molecular oxygen, the concentrations of selected antioxidant enzymes, and the susceptibility of p. carinii to in vitro killing by oxygen radical-generating systems have been evaluated. as expected of an organism which has been found to convert radiolabeled glucose to co2, the parasite utilizes molecular oxygen. no evidence for pathways of oxygen utilization other than the ... | 1984 | 6323317 |
| acquired immune deficiency syndrome (aids) trends in the united states, 1978-1982. | this report summarizes results of surveillance for the acquired immune deficiency syndrome (aids) in the united states by the centers for disease control through the first quarter of 1983. surveillance has been predominantly passive, supplemented by active follow-up of requests to the centers for disease control for pentamidine isethionate for treatment of pneumocystis carinii pneumonia. the 1,299 reported cases showed trends of increasing incidence among all risk groups: homosexual men (72 perc ... | 1984 | 6322585 |
| pneumocystis carinii pneumonia in renal-transplant recipients treated with cyclosporine and steroids. | fourteen of 156 renal-transplant recipients treated with cyclosporine and steroids developed pneumocystis carinii-related pneumonia (pcp) over a 19-month period. this was a significant change from past experience with this disease in renal-transplant patients receiving azathioprine and steroids (six cases among 179 patients from 1977 to 1981). epidemiological investigation failed to implicate either person-to-person or nosocomial spread of infection. cases of pcp occurred more frequently in male ... | 1984 | 6321606 |
| retinal manifestations of the acquired immune deficiency syndrome (aids): cytomegalovirus, candida albicans, cryptococcus, toxoplasmosis and pneumocystis carinii. | the ocular manifestations of 34 patients with the acquired immune deficiency syndrome (aids), are reviewed. cytomegalovirus retinitis was seen in 18 patients, cotton wool spots were observed in 11 patients with pneumocystis carinii pneumonia; fungal retinitis and toxoplasmosis retinochoroiditis were each seen in 2 patients. a review of literature regarding aids is included. | 1983 | 6320505 |
| [pneumocystis carinii infection in a homosexual adult subject with immunodeficiency: apropos of a case]. | 1983 | 6320330 | |
| pathologic features of the lung in the acquired immune deficiency syndrome (aids): an autopsy study of seventeen homosexual males. | the lungs of 17 homosexual males who died of the acquired immune deficiency syndrome were studied to determine the type and extent of pulmonary disease present at autopsy. all patients had two or more pathologic processes, including one or more infections in their lungs. cytomegalovirus pneumonia was the most common pulmonary infection identified at autopsy (15 patients) but was documented morphologically rarely during life (two patients). most patients with pneumocystis pneumonia had recurrent ... | 1984 | 6318549 |
| use of the transbronchial biopsy for diagnosis of opportunistic pulmonary infections in acquired immunodeficiency syndrome (aids). | the authors used a method that includes giemsa-stained touch preparations of a lung biopsy and culture of the same biopsy for viruses and microorganisms. the yield of etiologic agent diagnoses by this cytologic method was compared with yield from a simultaneous biopsy processed by usual histologic methods and stained by hematoxylin and eosin, silver methenamine, and other stains as necessary. fifty-nine transbronchial biopsies and eight open lung biopsies were processed on 38 male patients with ... | 1984 | 6318546 |
| pneumocystis carinii pneumonia and disseminated cytomegalovirus infection in previously healthy bisexual man. | 1983 | 6318460 | |
| transfusion-associated cytomegalovirus infection and acquired immune deficiency syndrome in an infant. | an infant who received multiple blood transfusions in the neonatal intensive care unit developed a transfusion-associated cmv infection at age 11 weeks and thereafter was noted to have hepatosplenomegaly, mitogen hyporesponsiveness, persistent viruria, an abnormal distribution of t-lymphocyte subpopulations, and poor growth. he has had recurrent opportunistic infections, including pneumocystis carinii pneumonia. six donors of blood products received by this infant were investigated; one was foun ... | 1983 | 6315905 |
| acquired immune deficiency syndrome. ocular manifestations. | the acquired immune deficiency syndrome (aids) is a recently described disorder of cellular immunity in homosexuals, intravenous drug abusers, and haitians. manifestations include kaposi's sarcoma, pneumocystis carinii pneumonia, and other opportunistic infections. ophthalmic and autopsy examinations of 30 patients at ucla revealed frequent ocular abnormalities. findings included cotton-wool spots (16 patients), cytomegalovirus retinitis (eight patients), conjunctivitis and keratitis (four patie ... | 1983 | 6314219 |
| gastrointestinal cytomegalovirus infection in a homosexual man with severe acquired immunodeficiency syndrome. | a 44-yr-old white homosexual man with a history of pneumocystis carinii pneumonia developed watery diarrhea and fever. flexible sigmoidoscopy revealed yellow plaques in the sigmoid colon suggestive of pseudomembranous colitis. stool examination for ova and parasites, clostridium difficile toxin, and cultures for pathogens, including clostridium difficile, were negative. infection with multiple organisms, including mycobacterium avium intracellulare, toxoplasma gondii, herpes simplex, and cytomeg ... | 1983 | 6313468 |
| [case of adult t-cell leukemia with generalized cytomegalovirus infection, pneumocystis carinii pneumonia and hypoimmunoglobulinemia]. | 1983 | 6310178 | |
| the acquired immunodeficiency syndrome. | recently, a new epidemic illness, the acquired immunodeficiency syndrome, has dramatically emerged in the united states, europe, and haiti. the syndrome represents an unprecedented epidemic form of immunodeficiency involving prominent defects of the t-lymphocyte arm of the immune system. pneumocystis carinii pneumonia, other opportunistic infections, and the previously rare cancer, kaposi's sarcoma, are the most conspicuous illnesses that have this profound state of immune compromise as their un ... | 1983 | 6309051 |
| national case-control study of kaposi's sarcoma and pneumocystis carinii pneumonia in homosexual men: part 2. laboratory results. | the centers for disease control conducted a case-control study to investigate an outbreak of kaposi's sarcoma and pneumocystis carinii pneumonia in homosexual men. the occurrence of these diseases was found to be associated with certain aspects of lifestyle, including a greater number of male sex partners per year, exposure to feces during sex, history of syphilis and non-b hepatitis, treatment for enteric parasites, and use of various illicit substances. laboratory studies reflected both this l ... | 1983 | 6309049 |
| immunologic alterations in bronchoalveolar lavage fluid in the acquired immunodeficiency syndrome (aids). | the association of pneumocystis carinii pneumonia and cytomegalovirus infection in apparently healthy intravenous drug abusers or homosexual males recently has been described. two patients with this syndrome were seen recently at our institution. bronchoalveolar lavage samples from these two patients, taken at the time of bronchoscopy, were analyzed. in both patients a significant increase in inflammatory cells (polymorphonuclear cells) and evidence for polyclonal b cell activation, as measured ... | 1983 | 6307101 |
| acquired immunodeficiency syndrome. a report of 2 south african cases. | this report documents the first 2 cases of the acquired immunodeficiency syndrome in male homosexuals identified in south africa. both patients died of pneumocystis carinii pneumonia and both had cytomegalovirus infection. neither had peripheral lymphadenopathy and in both cases the lymph nodes showed cortical and paracortical atrophy with marked plasma cell and histiocytic infiltration. it is suggested that this lymph node pattern represents the morphological expression of the immunological def ... | 1983 | 6306851 |
| adult respiratory distress syndrome in a previously healthy young male. | 1982 | 6305041 | |
| effects of interferon-alpha on cytomegalovirus reactivation syndromes in renal-transplant recipients. | we have previously demonstrated that six weeks of prophylaxis with interferon-alpha delays cytomegalovirus excretion and decreases viremia in recipients of kidney transplants. in a double-blind trial to evaluate the effects of a longer course of prophylaxis, we gave either 3 x 10(6) units of interferon or placebo intramuscularly to 42 patients before transplant surgery was performed. after surgery, doses were given three times a week for six weeks and then twice a week for eight weeks (total of ... | 1983 | 6304513 |
| combined infections of pneumocystis carinii and cytomegalovirus: a case report. | 1983 | 6304221 | |
| cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (aids). | two homosexual males with the "gay bowel syndrome' experienced an acute unilateral loss of vision. both patients had white intraretinal lesions, which became confluent. one of the cases had a depressed cell-mediated immunity; both patients ultimately died after a prolonged illness. in one patient cytomegalovirus was cultured from a vitreous biopsy. autopsy revealed disseminated cytomegalovirus in both patients. widespread retinal necrosis was evident, with typical nuclear and cytoplasmic inclusi ... | 1983 | 6303386 |
| symbiosis of pneumocystis carinii and cytomegalovirus in a case of fatal pneumonia. | 1983 | 6301670 | |
| diagnostic open lung biopsy for diffuse pulmonary disease in immunocompromised pediatric patients. | diagnostic open lung biopsy was performed in 40 pediatric patients with diffuse pulmonary disease and underlying malignancy or immunosuppression. specific diagnoses on which therapy could be based were made in 32 patients and there was only one false-negative result. pneumocystis carinii was diagnosed antemortem in 28 patients. complications of surgery occurred in six patients (15%), but no patients died as a result of the procedure. open lung biopsy appears to be a safe and effective diagnostic ... | 1982 | 6301305 |
| the acquired immunodeficiency syndrome and mycobacterium avium-intracellulare bacteremia in a patient with hemophilia. | a 27-year-old previously healthy man with hemophilia presented with pneumocystis carinii pneumonia. the patient had several episodes of oral candidiasis followed by disseminated infection with mycobacterium avium-intracellulare. he was not homosexual nor did he take illicit drugs, but he had been self-administering two to four monthly infusions of factor viii concentrate for 7 years. in-vitro lymphocyte studies showed findings consistent with the acquired immunodeficiency syndrome that had previ ... | 1983 | 6299154 |
| acquired immunodeficiency syndrome with pneumocystis carinii pneumonia and mycobacterium avium-intracellulare infection in a previously healthy patient with classic hemophilia. clinical, immunologic, and virologic findings. | a previously healthy patient with classic hemophilia who was on a home infusion program with factor viii concentrates developed an acquired immunodeficiency syndrome manifested by a dramatic weight loss (47 kg over 12 months), lassitude, transient thrombocytopenia, and opportunistic infections with varicella zoster, pneumocystis carinii, and mycobacterium avium-intracellulare. the patient was not homosexual and had no history of intravenous drug abuse. immunologic studies showed a persistent lym ... | 1983 | 6299153 |
| opportunistic infections and kaposi's sarcoma among haitians: evidence of a new acquired immunodeficiency state. | twenty haitian patients, hospitalized from 1 april 1980 to 20 june 1982, had pneumocystis carinii pneumonia, central nervous system toxoplasmosis, esophageal candidiasis, cryptococcosis, disseminated cytomegalovirus, progressive herpes simplex virus, chronic enteric coccidiosis, or invasive kaposi's sarcoma. ten patients died. opportunistic infections were frequently multiple and were recurrent in three patients. in seven patients disseminated tuberculosis preceded the other infections by 2 to 1 ... | 1983 | 6299151 |
| [pulmonary pneumocystosis]. | sixteen autopsy cases of adults and older children who had contracted pneumocystosis of the lung were observed macro- and microscopically. electron microscopical observation was done in 5 of these 16 cases. also experimental studies on the pathogenesis of this disease were carried out on 20 rats. most of the autopsy cases in this study had hematological neoplasia such as leukemia and malignant lymphoma which had been treated with cortisone and cytostatics. we found that intraalveolar foamy subst ... | 1982 | 6293422 |
| the role of transbronchial biopsy for the diagnosis of diffuse pneumonias in immunocompromised marrow transplant recipients. | we studied the use of transbronchial biopsy for the diagnosis of diffuse pneumonia in marrow transplant recipients. transbronchial biopsy results were directly compared with open-lung biopsy results by performing the procedures simultaneously in the same lobe of the lung and processing the specimens in parallel. there were 24 cases of pneumonia diagnosed in 22 patients. transbronchial biopsy correctly identified 3 of 5 cases of pneumocystis carinii and none of the 5 cases of viral pneumonia. the ... | 1982 | 6293351 |
| pneumocystis carinii pneumonia in an apparently nonimmunocompromised patient. | 1982 | 6289469 | |
| immunosuppression in a homosexual man with kaposi's sarcoma. | the occurrence of kaposi's sarcoma in young homosexual men is a recently reported condition. the same individuals are at risk for the development of pneumocystis carinii pneumonia and other unusual infections. these associations suggest these persons are somehow immunocompromised. evidence of current or prior cytomegalovirus (cmv) infection is seen in a high percentage of these and other homosexual men. cmv infections are known to induce alterations in the immunoregulatory suppressor and helper ... | 1982 | 6284810 |
| an outbreak of pneumocystis carinii pneumonia in homosexual men. | pneumocystis carinii pneumonia has rarely been reported in previously healthy persons over the age of 6 months. five cases of p. carinii pneumonia in adult homosexual men, confirmed by biopsy results, are reported. all five patients were seropositive when tested for antibodies to cytomegalovirus and four had evidence of active concurrent cytomegalovirus infections. kaposi's sarcoma was shown in two of the patients and one had possible pneumocystis infection of the central nervous system as well ... | 1982 | 6283975 |
| opportunistic infections and immune deficiency in homosexual men. | a syndrome of opportunistic infections and acquired immune deficiency occurred among four previously healthy homosexual men. fever, leukopenia, and diminished delayed hypersensitivity were accompanied by various degrees of proctitis, perianal ulcerations, and lymphadenopathy. the infectious agents included pneumocystis carinii, cryptococcus neoformans, candida albicans, herpes simplex virus, and cytomegalovirus. the immune deficiency was characterized as a persistent and profound selective decre ... | 1982 | 6283974 |
| pneumocystis carinii and cytomegalovirus pneumonia in a previously healthy adult. | a case of pneumocystis carinii pneumonia and cytomegalovirus infection occurring in a previously healthy adult male homosexual who was not receiving known immunosuppressive therapy is described. this 35-year-old man had been treated with metronidazole and tetracycline for an intermittent diarrheal illness of 5 months' duration. he was then admitted to the hospital where he was found to have a small infiltrate in the left lower lobe, and this process soon involved both lungs. initially, pneumocys ... | 1982 | 6282154 |
| atypical pneumocystis carinii pneumonia in homosexual men with unusual immunodeficiency. | pneumocystis carinii pneumonia is a well known opportunistic infection whose radiographic presentation and association with cytomegalovirus (cmv) have been well described. recently nine young homosexual men with chronic flulike illnesses were seen. bronchoscopy in six cases demonstrated evidence of cmw infection with pneumocystis pneumonia. the radiographic presentation was atypical. immunologic evaluation revealed t-cell abnormalities. cmv infections altering immunologic mechanisms has been pos ... | 1982 | 6282099 |
| pneumocystis carinii pneumonia in a male homosexual. | 1982 | 6281920 | |
| kaposi's sarcoma in young homosexual men. | an outbreak of ks has been observed in young homosexual men. these patients are different from those with classical ks for the following reasons: 1. geographic distribution (clustering in new york and california); 2. age (younger, mean--39 years); 3. higher incidence; 4. sexual preference (homosexual); 5. distribution of skin lesions (face, upper extremities, trunk); 6. lymph node involvement; 7. visceral lesions; 8. associated opportunistic infections (pneumocystis carinii, toxoplasmosis); 9. h ... | 1982 | 6276100 |
| severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. | four homosexual men presented with gradually enlarging perianal ulcers, from which herpes simplex virus was cultured. each patient had a prolonged course characterized by eight loss, fever, and evidence of infection by other opportunistic microorganisms including cytomegalovirus, pneumocystis carinii, and candida albicans. three patients died; kaposi's sarcoma developed in the fourth. all were found to have depressed cell-mediated immunity, as evidenced by skin anergy, lymphopenia, and poor or a ... | 1981 | 6272110 |
| pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. | four previously healthy homosexual men contracted pneumocystis carinii pneumonia, extensive mucosal candidiasis, and multiple viral infections. in three of the patients these infections followed prolonged fevers of unknown origin. in all four cytomegalovirus was recovered from secretions. kaposi's sarcoma developed in one patient eight months after he presented with esophageal candidiasis. all patients were anergic and lymphopenic; they had no lymphocyte proliferative responses to soluble antige ... | 1981 | 6272109 |
| [pneumocystis carinii pneumonia in patients with lung neoplasms]. | 1981 | 6270632 | |
| infant pneumonitis associated with cytomegalovirus, chlamydia, pneumocystis, and ureaplasma: a prospective study. | in a prospective study of 104 infants between 1 and 3 months of age hospitalized with pneumonitis, 65 (63%) had evidence of infection with one or more potential respiratory pathogens. single infections were noted in 48 (74%) whereas mixed infections occurred in 17 (26%) of 65 infected infants. the four most common infections were chlamydia trachomatis (15/59, 25%), ureaplasma urealyticum (8/38, 21%), cytomegalovirus (21/104, 20%), and pneumocystis carinii (19/104, 18%). in sharp contrast, the in ... | 1981 | 6269042 |
| [infections in children with leukaemia or malignant tumour treated with cytostatic agents: long-term study of 200 cases (author's transl)]. | all children with leukaemia or malignant tumour receiving cytostatic agents were followed by virological tests over three years. serological tests or virus isolation in 200 children demonstrated 238 instances of viral infection. only those of the herpes group led to severe symptoms which, however, responded to treatment. the course of infections induced by respiratory viruses was no different from that in children not receiving immunosuppressive agents. it was possible, by using a "virus risk re ... | 1981 | 6260450 |
| [a case of adult t-cell type lymphoma with generalized cytomegalovirus infection and pneumocystis carinii pneumonia (author's transl)]. | 1980 | 6256559 | |
| pneumocystis carinii pneumonitis in patients with lung cancer. | pneumocystis carinii pneumonia was histologically documented in five patients with bronchogenic carcinoma. all patients had been treated with combination antineoplastic chemotherapy. two patients received no corticosteroids, two received no chest radiotherapy, and one received neither radiotherapy nor corticosteroids. this suggests that as more patients with lung cancer are treated with intensive chemotherapy, pulmonary infection with p carinii may become an important differential diagnostic con ... | 1980 | 6253235 |
| [results of a protocol for etiologic diagnosis of pneumopathies on immunosuppressed children (author's transl)]. | a protocol for etiologic diagnosis has been used on 40 immuno suppressed children with pulmonary infiltrate. the purpose of this protocol is to permit an early etiologic diagnosis, concomitant infections by several pathogen agents being frequently seen. an endobronchial brushing is first performed; the results being obtained between 24 to 48 hours. if the results are negative and the patient's condition worsens we propose an open lung biopsy. thus pathogenic agent has been established in 24 case ... | 1980 | 6252614 |
| cytomegalovirus and dual infection in infants. | in four unrelated infants without underlying immunodeficiency, dual infections with cytomegalovirus (cmv) and another microorganism developed. the patients included the following: (1) a 3-month-old girl with congenital cmv and perinatal cutaneous herpes simplex virus; (2) a 5-week-old girl with cmv and pneumocystis carinii; (3) a 12-week-old girl with cmv and haemophilus influenzae meningitis; and, (4) a 2 1/2-month-old girl with cmv and escherichia coli meningitis. in all four cases, the patien ... | 1980 | 6244804 |
| [pneumocystis carinii diffuse alveolo-interstitial pneumopathy and legionella pneumophila infection in an immunosuppressed child]. | 1984 | 6239226 | |
| pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. | clinical features of 49 episodes of pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome were compared with those of 39 episodes in patients with other immunosuppressive diseases. at presentation patients with the syndrome were found to have a longer median duration of symptoms (28 days versus 5 days, p = 0.0001), lower mean respiratory rate (23.4 versus 30, p = 0.005), and higher median room air arterial oxygen tension (69 mm hg versus 52 mm hg, p = 0.0002). th ... | 1984 | 6231873 |
| the acquired immunodeficiency syndrome in patients with hemophilia. | since mid-1981 the centers for disease control (cdc) has received reports of more than 1900 cases of the acquired immunodeficiency syndrome. these cases had either kaposi's sarcoma confirmed by biopsy or a life-threatening opportunistic infection confirmed by biopsy or culture. in january 1982 a hemophiliac with pneumocystis carinii pneumonia was reported to the cdc, and by july 1982 two other hemophiliacs had developed p. carinii pneumonia. during the next 12 months a total of 22 confirmed case ... | 1984 | 6230977 |
| adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. | we reviewed the charts of 38 patients with the acquired immunodeficiency syndrome who were treated for pneumocystis carinii pneumonia. only 5 of 37 patients started on trimethoprim-sulfamethoxazole were able to complete treatment; in 29 patients drug toxicity occurred and in 19 treatment was changed due to adverse reactions that included rash, fever, neutropenia, thrombocytopenia, and transaminase elevation. pentamidine was given to 30 patients (1 as initial treatment); toxicity occurred in 13 b ... | 1984 | 6230976 |
| acquired immunodeficiency syndrome in african patients. | between may 1979 and april 1983, 18 previously healthy african patients were hospitalized in belgium with opportunistic infections (cryptococcosis, pneumocystis carinii pneumonia, central-nervous-system toxoplasmosis, progressive cutaneous herpes simplex virus infection, disseminated cytomegalovirus infection, candidiasis, or cryptosporidiosis) or kaposi's sarcoma, or with both. ten of them died. during the same period five other patients were hospitalized with an illness consistent with a prodr ... | 1984 | 6229701 |
| the acquired immunodeficiency syndrome in the wife of a hemophiliac. | a 71-year-old previously healthy woman developed unexplained thrush, onychomycosis, pneumocystis carinii pneumonia, and a t-cell defect consistent with the acquired immunodeficiency syndrome. her only apparent risk factor was infrequent, monogamous sexual contact with her husband, a 74-year-old hemophiliac who had received factor viii concentrate and subsequently died due to p. carinii pneumonia. she first developed probable signs of the syndrome (recurrent thrush and onychomycosis) 1 year befor ... | 1984 | 6229203 |
| acquired immunodeficiency syndrome in a colony of macaque monkeys. | a naturally occurring immunodeficiency syndrome has been seen in a captive colony of macaque monkeys. this syndrome is seen primarily in the species macaca cyclopis. affected animals died with lymphomas (a rare disease in macaques) or such opportunistic infections as pneumocystis carinii and noma (necrotizing gingivitis). these m. cyclopis exhibited anemia, neutropenia, and a circulating bizarre immature monocyte. in addition, liver function tests suggested hepatitis. pokeweed mitogen-, concanav ... | 1983 | 6221343 |
| t-lymphocyte subpopulation abnormalities in apparently healthy patients with hemophilia. | t-lymphocyte populations in 12 apparently healthy heterosexual adult patients with hemophilia have been examined to ascertain if these patients have abnormalities in their lymphocyte subpopulations similar to those in homosexual men, haitian refugees, and narcotic addicts. a striking reduction in the helper to suppressor cell ratio ([0.86 +/- 0.14]:1) was found in 9 of the 12 patients. these abnormalities were similar to those previously described in two patients with hemophilia critically ill w ... | 1983 | 6219601 |
| community-acquired opportunistic infections and defective cellular immunity in heterosexual drug abusers and homosexual men. | fourteen previously healthy young patients with unusual community-acquired opportunistic infections were seen over a period of three years. they differ from patients previously described in that 11 were heterosexual drug abusers (including two women) and only three were homosexual men. there were eight puerto ricans, five blacks, and one white. infections included pneumocystis carinii pneumonia (seven), disseminated mycobacterium intracellulare infection, histoplasmosis, cryptococcosis, and cyto ... | 1983 | 6219579 |
| acquired immune deficiency in haitians: opportunistic infections in previously healthy haitian immigrants. | we describe acquired immune deficiency manifested by opportunistic infections in 10 previously healthy heterosexual haitian men. the opportunistic pathogens included toxoplasma gondii (in four patients), cryptococcus neoformans (in one), pneumocystis carinii (in four patients), and candida albicans (in three). six of the patients also had mycobacterium tuberculosis. immunologic studies of three patients showed a decrease in the numbers and activity of helper t cells, with normal or increased pop ... | 1983 | 6217423 |
| a reliable silver staining method for identification of pneumocystis carinii in histologic sections. | the acquired immune deficiency syndrome (aids) is characterized by the development of kaposi's sarcoma and several opportunistic infections including pneumonia caused by pneumocystis carinii. as a staining method for pneumocystis carinii, the methenamine-silver nitrate method has been used routinely. most of fungi can be stained easily by this technique but the identification of pneumocystis carinii is not always easy. the author has improved the method by using ammoniacal silver nitrate and fou ... | 1984 | 6208635 |
| the effect of corticosteroid treatment on the cell surface glycocalyx of the rat pulmonary alveolus: relevance to the host-parasite relationship in pneumocystis carinii infection. | pneumocystis carinii infection is characterized by the attachment of p. carinii to host alveolar type i cell and propagation of the organism with corticosteroid administration. we have examined the effects of corticosteroids on the cell surface glycocalyx of the pulmonary alveolus in rats by ultrastructural histochemistry using cationized ferritin, ruthenium red and concanavalin a-horseradish peroxidase techniques. in rats treated for 4 and 6 weeks, the amount of the alveolar cell surface glycoc ... | 1984 | 6204668 |
| [specific staining method for pneumocystis carinii]. | 1984 | 6204075 | |
| treatment with rifampicin for pneumocystis carinii pneumonia. | the role of rifampicin in the treatment of serologically proved pneumocystis carinii pneumonitis was reported recently from poland (1). serum antibody or antigen levels alone provide uncertain evidence as by four years of age two-thirds of normal children may have significant titres (2). we present the first case treated with rifampicin, and proven by open lung biopsy. | 1984 | 6203475 |
| acquired immune deficiency syndrome, leading to opportunistic infections, kaposi's sarcoma, and other malignancies. | in early 1981 several cases of pneumocystis carinii pneumonia in young male homosexuals were recognized. between then and the end of 1982 almost 800 cases of serious opportunistic infections and malignancies have occurred in this group and now in other groups as well. the most common malignant disease to be seen is the otherwise uncommon endothelial cell sarcoma, kaposi's sarcoma. the underlying abnormality, both to the opportunistic infections and the malignancies, is one of acquired immune def ... | 1984 | 6202462 |
| wright's stain in rapid diagnosis of pneumocystis carinii. | the conventional hematology wright's stain has been used in touch preparation from open lung biopsies to identify pneumocystis carinii. a 100% positive correlation has been found using this rapid and readily available technique when compared to the conventional silver stain and permanent histologic sections. | 1984 | 6199969 |
| pneumocystis carinii identified by gram stain of lung imprints. | the diagnosis of pneumocystis carinii pneumonia conventionally depends on the time-consuming demonstration of the organisms in pulmonary secretions or lung tissue using toluidine blue 0, methenamine silver, or gram weigert stains that require special reagents. in 27 recent episodes of moderate to heavy pneumocystis infections, the cyst form and internal sporozoites of p. carinii could be readily identified on lung imprints using the conventional gram stain. the gram stain is unlikely to replace ... | 1983 | 6194727 |
| [staining of pneumocystis carinii in tissue section: a reliable silver staining method]. | 1982 | 6182316 | |
| comparison of two methods used to prepare smears of mouse lung tissue for detection of pneumocystis carinii. | the laboratory diagnosis of pneumocystis carinii pneumonia in humans includes the identification of cysts in stained lung tissue impression smears. by using a mouse model, we compared the number of cysts in lung tissue impression smears with those contained in a concentrate of homogenized lung tissue. eleven c3h/hen mice developed p. carinii infection after corticosteroid injections, a low protein (8%) diet, and tetracycline administered in drinking water. impression smears were prepared with fr ... | 1982 | 6181088 |
| laboratory diagnosis of pneumocystis carinii infection. | 1982 | 6180860 | |
| ten-minute silver stain for pneumocystis carinii and fungi in tissue sections. | a ten-minute methenamine silver staining procedure for the rapid demonstration of pneumocystis carinii and fungi in tissue sections has been developed. the procedure is optimal for both urgent and routine histologic diagnosis of diffuse, progressive, and life-threatening pulmonary infiltrates, especially in the compromised host, and of fungal lesions in general. moreover, it is simple and brief, is applicable to both paraffined and frozen sections, and can easily be used by the pathology residen ... | 1982 | 6178384 |
| metabolic and synthetic activities of pneumocystis carinii in vitro. | pneumocystic carinii organisms obtained from the lungs of rats with glucocorticoid-induced pneumocystosis retained a number of metabolic activities during in vitro culture for 48 to 72 h. they were able to metabolize [14c]glucose to 14co2, to synthesize proteins from 3h-amino acids, and to synthesize ribonucleic acid from [3h]uridine. utilization of [14c]glucose was inhibitable by excess unlabeled glucose, mannose, fructose, 2-deoxy-d-glucose, iodoacetate, and pentamidine, but not glycerol or tr ... | 1981 | 6174453 |
| [pneumocystis carinii delanoe and delanoe, 1912. the different methods of identification (author's transl)]. | pneumocystis carinii pneumonia diagnosis relates on the direct detection of parasites from samples giving the best productivity. the various methods of identification do not detect the same structures. their efficacity is evaluated using parasites from immunodepressed rat lungs. our experience confirms that toluidine blue o stain may be first realized, eventually associated with grocott's method. | 1981 | 6173008 |
| pneumocystis infection masquerading as diffuse alveolar damage: a potential source of diagnostic error. | the nonspecific histopathologic changes of diffuse alveolar damage (dad) were the only findings in nine of 17 lung biopsy specimens containing pneumocystis carinii infection. because of the frequent absence of the classically described intra-alveolar frothy material, special stains for organisms should be performed on all biopsy specimens from immunocompromised patients that show dad, and the diagnosis of pneumocystis infection should not be discarded unless careful search for organisms using sp ... | 1981 | 6164519 |
| in vitro effects of antiprotozoan drugs and immune serum on pneumocystis carinii. | the in vitro survival of pneumocystis carinii isolated from the lungs of rats with glucocorticoid-induced pneumocystosis has been evaluated by quantitation of uptake of vital dyes by the organisms after exposure to a variety of drugs, immune serum, and medium enriched with macrophage lysosomal enzyme. on the basis of these tests, it appears that pentamidine and chloroquine are directly lethal to the organisms, but that suramin, trimethoprim, and sulfamethoxazole are not. neither immune serum sup ... | 1980 | 6156221 |
| comparison of histological and immunological techniques for detection of pneumocystis carinii in rat bronchial lavage fluid. | we compared histological and immunological techniques in the early diagnosis of pneumocystis carinii pneumonia in bronchial lavage fluid of steroid-treated rats. the rats were sacrificed weekly and lavage fluids were: (i) examined with cresyl echt violet and giemsa stains; (ii) examined for p. carinii antigens by indirect fluorescent-antibody, counterimmunoelectrophoresis, and double-diffusion techniques, using high-titer spectific antisera to p. carinii raised in rabbits. p. carinii was detecte ... | 1980 | 6154719 |
| misdiagnosis caused by fungal contaminant in a histological stain solution. | silver stains on tissue and cytology specimens are important in the evaluation of patients with suspected fungal infections. care must be taken, however, to prevent misinterpretation of contamination artifacts. two cases presenting such a problem are reported. the first patient had granulomatous leg lesions that microscopically showed characteristics of erythema induratum but with budding yeastlike organisms demonstrated by grocott methenamine silver stain. cultures and subsequent biopsies were ... | 1980 | 6153661 |
| needlestick transmission of htlv-iii from a patient infected in africa. | this article reports a case of needlestick transmission of human t-lymphotropic virus type iii (htlv-iii) infection to a health care worker in the uk from a patient who was presumably infected while in africa. the patient, a white woman who had lived in central southern africa, presented at the hospital with general malaise, dry cough, and fever. lung biopsy revealed pneumocystis carinii pneumonia infection, and the patient was seropositive for htlv-iii infection with a titer of 260. the pati ... | 1984 | 6150372 |
| oral "hairy" leucoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus. | an outbreak of a new form of oral leucoplakia, found principally on the lateral borders of the tongue, is reported in male homosexuals in the san francisco area. many of the patients showed evidence of immunosuppression, and candida was often found in the lesions. the characteristic histology is similar to that of the flat wart of skin. there was immunocytochemical evidence of papillomavirus core antigen in 77% of 30 biopsy specimens, but no papillomaviruses were detected by electron microscopy ... | 1984 | 6148571 |
| fluorescence of pneumocystis carinii in papanicolaou smears. | pneumocystis carinii organisms can be identified in routine cytologic smears stained by the papanicolaou method and viewed under ultraviolet light in a fluorescence microscope. the organisms can be identified easily in thin, well-preserved cytologic smears. no false-positive results were obtained when 55 papanicolaou smears of bronchial washings were observed by this method. twenty-three of these smears were from patients with pneumocystic carinii pneumonia in whom the acquired immunodeficiency ... | 1984 | 6148303 |
| cyclosporin and steroids in renal transplantation: risk of pneumocystis carinii pneumonia? | 1984 | 6147670 | |
| prophylaxis of pneumocystis carinii infection in aids with pyrimethamine-sulfadoxine. | 1984 | 6147471 | |
| follicular dendritic cells and virus-like particles in aids-related lymphadenopathy. | follicular labyrinthine foci, consisting of an association of retrovirus-like particles with expanded dendritic reticular ("antigen trapping") cells, are described in lymph nodes from four immunodeficient homosexual men with unexplained persistent lymphadenopathy. one patient has severe acquired immunodeficiency syndrome (aids) with complicating pneumocystis carinii infection, and the others have aids-related lymphadenopathy syndrome. the findings support a role for routine electron microscopy a ... | 1984 | 6147453 |
| pentamidine or co-trimoxazole for pneumocystis carinii pneumonia. | 1983 | 6139634 | |
| complications of co-trimoxazole in treatment of aids-associated pneumocystis carinii pneumonia in homosexual men. | in 8 of 18 homosexual men with the acquired immunodeficiency syndrome (aids) and pneumocystis carinii pneumonia (pcp) treated with intravenous co-trimoxazole (trimethoprim-sulphamethoxazole) apparent drug-related complications developed during the course of acute therapy. a symptom complex of fevers and increasing malaise, often with nausea and headaches, developed usually after 9 days of therapy at a daily dosage of 20 mg/kg of trimethoprim and 100 mg/kg of sulphamethoxazole. these symptoms wer ... | 1983 | 6138645 |
| acquired immunodeficiency syndrome with severe gastrointestinal manifestations in haiti. | 29 patients (19 males and 10 females) in haiti were diagnosed as having acquired immunodeficiency syndrome. their clinical presentation was characterised by unexplained chronic diarrhoea, prolonged fever, extreme weight loss, anorexia, and severe infections. the infectious agents included: candida albicans (27 patients), mycobacterium tuberculosis (7 patients), cryptosporidium (11 patients), pneumocystis carinii (2 patients), cytomegalovirus (4 patients), and herpes virus (3 patients). in 1 woma ... | 1983 | 6137696 |
| rifampicin for pneumocystis carinii pneumonia. | 1983 | 6135006 | |
| [pneumocystis carinii pneumonia in a patient with polyarteritis nodosa treated with prednisone and cyclophosphamide]. | 1982 | 6129360 | |
| should inpatients with pneumocystis carinii be isolated? | 1982 | 6123776 | |
| response of pneumocystis carinii pneumonia only after high-dose cotrimoxazole. | 1982 | 6119554 | |
| primary pneumocystis carinii and cytomegalovirus infections. | 1981 | 6118728 | |
| treatment and prophylaxis of pneumocystis carinii pneumonia. | 1980 | 6106370 | |
| acquired immunodeficiency syndrome. | a retrovirus designated htlv-iii has been recovered from patients with aids and patients with pre-aids syndrome. this virus, which appears to be the cause of aids, attacks and suppresses t-helper lymphocytes, rendering the host susceptible to a variety of serious protozoal, fungal, mycobacterial, bacterial and viral infections, as well as neoplasms. pneumocystis carinii and cytomegalovirus are frequent causes of pulmonary infiltrates in aids. | 1984 | 6095629 |
| cellular and t-lymphocyte subpopulation profiles in bronchoalveolar lavage fluid from patients with acquired immunodeficiency syndrome and pneumonitis. | the cellular composition and t-lymphocyte subpopulations of bronchoalveolar lavage (bal) fluid from 12 patients with acquired immunodeficiency syndrome (aids) and active pneumonitis were examined. differential cell counts were performed on bal specimens from each patient and from 25 normal subjects. the bal and peripheral blood (pb) lymphocytes were isolated from 8 patients and 11 subjects. leu 4 (mature t), leu 2 (t suppressor), and leu 3 (t helper) markers were identified by fluorescein-labele ... | 1984 | 6093655 |
| diagnosis of pulmonary disease in acquired immune deficiency syndrome (aids). role of bronchoscopy and bronchoalveolar lavage. | the effectiveness of fiberoptic bronchoscopy with the addition of bronchoalveolar lavage (bal) was evaluated in 72 patients with the acquired immune deficiency syndrome (aids) and parenchymal pulmonary disease. the diagnostic yield varied for different pathogens and was 94% (45/48 cases) for pneumocystis carinii, 67% (14/21 cases) for cytomegalovirus, and 62% (8/13 cases) for mycobacterium avium intracellulare. of the 11 cases of documented kaposi's sarcoma in the lung parenchyma, none were diag ... | 1984 | 6091509 |