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the immunologic response to plasmodium. 19724561519
immunopathological studies of plasmodium berghei-infected mice. immune complex nephritis. 19724560395
suppression of the immune response to heterologous erythrocytes in mice infected with plasmodium berghei berghei. 19724558679
a cytoplasmic polyhedrosis virus in midgut cells of anopheles stephensi and in the sporogonic stages of plasmodium berghei yoelii.although it has been known for some time that nuclear and cytoplasmic polyhedrosis viruses may infect the larval stages of mosquitos capable of transmitting mammalian malaria this paper reports for the first time the presence of a cytoplasmic polyhedrosis virus in adult anopheles stephensi. the virus was shown to be present in sporogonic stages of plasmodium berghei yoelii with which the mosquitos were infected. it is possible that other viruses may affect both vector and malaria parasites. furt ...19724557906
effect of paba on chloroquine resistance in plasmodium berghei yoelii. 19724557790
[the effects of chloroquine on mice infected with plasmodium berghei (malaria)]. 19724515076
effect of stimulation of the host defense system by coenzyme q 10 on dibenzpyrene-induced tumors and infection with friend leukemia virus in mice.members of the coenzyme q group increase the phagocytic activity in rats, as measured by the carbon clearance technique, and increase the hemolytic antibody formation in mice. in addition, prior treatment with low doses of chloroquine hydrochloride combined with coenzyme q(10) results in increased numbers of survivors, prolonged survival time, and reduced parasitemia in blood-transferred plasmodium berghei infection in micein an extension of these studies, using emulsions of coenzyme q(10), i de ...19734510283
plasmodium berghei nk65 in the inbred a-j mouse: immunity in the a-j mouse naturally recovered from nk65c and challenged with nk65e. 19724403780
plasmodium berghei nk65 in the inbred a-j mouse: age immunity in the female retired breeder a-j mouse. 19724403779
electrophoretic forms of glucose phosphate isomerase in oöcysts and blood parasites of plasmodium berghei. 19724403636
the adverse effects of a microsporidan on sporogony and infectivity of plasmodium berghei. 19714398586
post-meiotic nuclear divisions in the oöcyst of plasmodium berghei. 19714398585
the amino acid oxidases of plasmodium berghei. 19714397436
[results of 2 years of observation of the cyclical transmission of plasmodium berghei]. 19684397432
ultrastructural localisation of nadh- and nadph-dehydrogenases in the erythrocytic stages of the rodent malaria parasite, plasmodium berghei. 19704393193
cultivation in vitro of sporozoites of plasmodium berghei. 19704392591
plasmodium berghei dihydrofolate reductase. isolation, properties, and inhibition by antifolates. 19694392112
folate cofactor biosynthesis by plasmodium berghei. comparison of folate and dihydrofolate as substrates. 19664381842
life cycle and patterns of development of plasmodium berghei in normal and experimental hosts. 19664380325
inhibition of the immune response to pertussis vaccine during plasmodium berghei yoelii infection in mice.mice infected with plasmodium berghei yoelii responded poorly to pertussis vaccine when administered at peak parasitemia. this was shown by serum agglutinin titers and lack of protection against intracerebral challenge with virulent bordetella pertussis.19744375413
the effect of rowson-parr virus on the severity of malaria in mice. 19744375171
the chemotherapy of rodent malaria. xx. autophagic vacuole formation in plasmodium berghei in vitro. 19744374902
interaction of mouse strain and differential housing upon resistance to plasmodium berghei. 19734355344
the enzymic synthesis of dihydropteroate and dihydrofolate by plasmodium berghei. 19734354403
the initiation of a "metabolic window" in the surface of host erythrocytes by plasmodium berghei nyu-2. 19734351644
antimetabolites of coenzyme q. 16. new alkylmercaptoquinones having antimalarial curative activity. 19734345639
respiration in intra-erythrocytic plasmodium berghei. 19724340172
preliminary observations concerning antibody response to infleunza virus and sheep erythrocytes of mice infected with plasmodium berghei. 19724336997
[interferon and protection of mice against experimental infestation transmitted by the blood forms of plasmodium berghei injected in massive doses. i. methods of protection with a viral inducer of interferon]. 19714333125
localization of acid phosphatase activity in plasmodium berghei and p. gallinaceum: an electron microscopic observation. 19714326304
pathologic physiology and chemotherapy of plasmodium berghei. ix. gastric secretion and the influence of 1-aminocyclopentane carboxylic acid (wr 14, 997 or cycloleucine). 19694323536
malarial parasite metabolism: the glutamic acid dehydrogenase of plasmodium berghei. 19704323390
p-enolpyruvate carboxylase from plasmodium berghei. 19714322552
cytochrome oxidase activity in a normal and some drug-resistant strains of plasmodium berghei--a cytochemical study. ii. sporogonic stages of a drug-sensitive srain. 19704321622
mitochondrial changes during the life cycle of plasmodium berghei. 19704321621
cytochrome oxidase activity in a normal and some drug-resistant strains of plasmodium berghei--a cytochemical study. i. asexual erythrocytic stages. 19694316152
the ultrastructural distribution of cytochrome oxidase activity in plasmodium berghei and p. gallinaceum. 19694307398
cytochemical observations on plasmodium berghei and p. gallinaceum. 19694307032
studies on the phospholipids of mouse spleen on infection with plasmodium berghei. 19674298940
metabolism of plasmodium berghei. i. krebs cycle. 19684296129
[the erythrogram in the convalescent stage of rodent malaria (plasmodium berghei) after treatment with camolar]. 19704283602
plasmodium berghei infection in mice. an ultrastructural study of immune complex nephritis.renal glomeruli of plasmodium berghei infected mice were studied electron microscopically. the endothelial cell proliferation and endothelial cytoplasmic changes were greatly stimulated on day 7, at the time when there were collections of dense granular aggregates in the glomerular capillary lumens and electron-dense deposits in the mesangial areas. the basement membrane lesion developed with the infiltration of polymorphonuclear leucocytes on day 14 with more electron-dense deposits in the mesa ...19734264779
[development of plasmodium berghei berghei in mice embryos]. 19714263149
[action of neuroleptics and tranquilizing agents on mice with plasmodium berghei malaria]. 19694259166
malarial parasite metabolism: the lactic acid dehydrogenase of plasmodium berghei. 19694237665
the movement of the dye (disulphine blue) from blood into brain tissue examined by dye method in normal and plasmodium berghei infected mice. 19684234391
metabolism of plasmodium berghei. ii. 32p incorporation into high-energy phosphates. 19684230644
the oxygen consumption of plasmodium berghei in the presence of normal rat serum, immune rat serum and chloroquine sulfate. 19654221414
recent advances in antimalarial chemotherapy and drug resistance. 19744217563
prospects for vaccination against malaria in man.rodents have been successfully protected against a challenge of viable plasmodium berghei by employing as vaccine: (1) the irradiated blood stages of the same parasite, or (2) the water-insoluble fraction of the blood stages, or (3) irradiated sporozoites; all these vaccines were shown to be stage-specific. a method is outlined for testing in the field, in the absence of any risks, the efficacy of analogous vaccines against falciparum malaria in man. it is emphasized that: (1) the efficacy of th ...19744216411
parasitic protozoa of the blood of rodents: a revision of plasmodium berghei. 19744214369
[antiparasitic activity of hyperimmune serum produced in rabbits with solubilized cell membranes of plasmodium berghei]. 19734214021
methotrexate analogs. 3. synthesis and biological properties of some side-chain altered analogs. 19744213249
mesoionic purinone analogs. 7. in vitro antibacterial activity of mesoionic 1,3,4-thiadiazolo(3,2-a)pyrimidine-5,7-diones. 19744213245
inhibition of mammalian dihydrofolate reductase by selected 2,4-diaminiquinazolines and related compounds. 19744213189
recent research on malaria in mammals excluding man. 19734210072
6-phosphogluconate dehydrogenase activity in malaria-infected erythrocytes. 19734204745
some aspects of intracellular parasitism.in intracellular parasitism the host cell is a true and hospitable host. the parasite does not have to break in the door. it has subtle ways of inducing the host to open the door and welcome it in. one of the exciting fields in the future of parasitology is to find out what these ways are and why they are sometimes so highly specific that the cell that invites one parasite in will not open the door to another closely related species. once inside, the parasite not only exploits nutrients already ...19744203157
immunogenicity and infectivity of sporozoites of mammalian malaria isolated by density-gradient centrifugation. 19734202832
activity and some properties of an acid proteinase from normal and plasmodium berghei-infected red cells. 19734202515
synthesis and antimalarial effects of 1-(3,4-dichlorophenyl)-3-(4-((1-ethyl-3-piperidyl)amino)-6-methyl-2-pyrimidinyl)guanidine and related substances. 19744202215
an electron cytochemical study of 6-phosphogluconate dehydrogenase activity in infected erythrocytes during malaria. 19734201713
pyrrole antibacterial agents. 1. compounds related to pyoluteorin. 19734201184
pteridines. 2. new 6,7-disubstituted pteridines as potential antimalarial and antitumor agents. 19734200929
difference in surface charge between host cells and malarial parasites. 19734200702
[use of the antigen plasmodium berghei for the serodiagnosis of human malaria using indirect immunofluorescence]. 19724199597
malaria studies in vitro. ii. the measurement of drug activities using leucocyte-free blood-dilution cultures of plasmodium berghei and 3h-leucine. 19734198618
plasmodium berghei: folic acid levels in mouse erythrocytes. 19734197972
influence of plasmodium berghei yoelii or p. chabaudi or both on the course of splenomegaly and immunoglobulins in mice. 19694186077
[changes in serum proteins and protective immunity in malaria (plasmodium berghei) of mice]. 19674176064
autoimmune reactions in rats with plasmodium berghei infection. 19664163375
the asexual and sexual circadian rhythms of plasmodium vinckei chabaudi, of p. berghei and of p. gallinaceum. 19724156397
assessment of causal prophylactic activity in plasmodium berghei yoelii and its value for the development of new antimalarial drugs.the causal prophylactic activity of several reference and experimental antimalarial compounds was assessed in sporozoite-induced infections of nmri mice with plasmodium berghei yoelii (strain 17x). the animals were inoculated with 10 000 sporozoites per mouse and treated once 2-4 hours later. the test system has proved to be very suitable in experiments involving more than 3 000 mice. the infection rate in 448 untreated controls was 97.3%. lowering the sporozoite content of the inoculum to 1 000 ...19744155355
observations on the sporogonic cycle of plasmodium berghei in two australasian anophelines. 19744152304
8-(omega-aminoalkylamino)quinolines as potential prophylactic antimalarials. 19744151456
proceedings: hydrolases of the sporogonic stage of plasmodium berghei nigeriensis. 19744150466
observations on the binding site for antimalarial schizontocides. 19734149673
plasmodium berghei: mechanisms and sites of resistance to sporogonic development in different mosquitoes. 19734149337
citric acid cycle activity and chloroquine resistance in rodent malaria parasites: the role of the reticulocyte. 19734148616
further studies on the mitochondrial changes during the life cycle of plasmodium berghei: electrophoretic studies on isocitrate dehydrogenases. 19734148615
antimetabolites of coenzyme q. 20. synthesis of new alkyl-5,8-quinoxalinequinones as potential inhibitors of coenzyme q and as antimalarial drugs. 19734147839
studies on the motility of plasmodium sporozoites. 19744138523
surface properties of extracellular malaria parasites: morphological and cytochemical study.morphological and cytochemical surface characteristics of isolated malaria parasites (plasmodium berghei) and host erythrocytes were compared by electron microscopy by using thin section and carbon replica techniques. erythrocytes were uniform in shape and had fine, granular surfaces. in contrast, free parasites exhibited a variety of sizes, shapes, and surface textures. fine surface stippling was a common topographical feature of isolated parasites. small, infective forms often had patterned su ...19744132619
plasmodium sp.: topography of intra- and extracellular parasites. 19734130524
an electron microscope-cytochemical method for differentiating membranes of host red cells and malaria parasites. 19734128533
antigenic studies on plasmodium berghei and their relations to genetic work. 19724116049
nile blue stain: plasmodium berghei and uninfected erythrocytes. 19724114705
supravital staining of plasmodium berghei. 19714110489
murine malaria. 3. protein concentrations during plasmodium berghei infection. 19714110097
plasmodium berghei infection in neonatallythymectomized hamsters. 19714101132
preliminary studies on the use of ferritin-conjugated antibodies to plasmodium berghei. 19714100660
antibody levels in mice infectedwith plasmodium berghei yoelii. 19704099406
sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine as potential antimalarial agents.two isomeric sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2) were prepared and tested for antimalarial activity. the compounds were evaluated for blood schizonticidal activity against plasmodium berghei in mice and radical curative activity against plasmodium cynomolgi in rhesus monkeys. in addition, they were evaluated for causal prophylactic activity against plasmodium berghei yoelii in mice. both compounds were more active and less toxi ...19854068013
4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues as potential antimalarial agents.five 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues were synthesized and tested for radical curative activity against plasmodium cynomolgi in rhesus monkeys and for blood schizonticidal antimalarial activity against plasmodium berghei in mice. in addition, they were evaluated for causal prophylactic antimalarial activity against plasmodium berghei yoelii in mice. one compound, 4-ethyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2b), showed radical curative activity equivalent to ...19854067985
activities of the tetrahydrofuran derivative, ba-41,799, against plasmodium cynomolgi infections in rhesus monkeys.ba-41,799, a tetrahydrofuran derivative that at one time attracted considerable interest as an antimalarial agent because of a combination of structural novelty with activities against infections with plasmodium berghei and plasmodium berghei yoelii in mice, has been evaluated for its capacities to effect prophylaxis and radical cure in rhesus monkeys challenged or already infected with sporozoites of the drug-susceptible ro strain or the pyrimethamine-resistant ro/pm strain of plasmodium cynomo ...19853985599
effects of p-aminobenzoic acid, methionine, threonine and protein levels on susceptibility of mice to plasmodium berghei.the effects of dietary p-aminobenzoic acid (paba), protein, methionine and threonine on plasmodium berghei infection in mice were investigated. animals were fed diets containing 12 or 20% casein supplemented with paba (0 or 2 mg/kg diet), methionine (0 or 15 mg/g casein) and threonine (0, 7.5, 27.5 or 47.5 mg/g casein). percent mortality was lower in rats fed diets without paba than in those fed diets containing paba. all further experiments were conducted without supplemental paba. while the me ...19853934351
interactions of plasmodium berghei-infected erythrocytes with complement.incubation of radioactively labeled parasitized (plasmodium berghei) erythrocytes (pe) with adherent peritoneal exudate cells in the presence of 10% (v/v) fresh mouse serum (nms) resulted in the uptake of a proportion of radioactive material (pe). inactivation of the added serum by heat or zymosan treatment resulted in diminished uptake of radioactivity. these results suggest that pe activated complement. incubation of fresh nms with pe reduced the hemolytic complement level of the serum as show ...19853925133
rhoptry secretion of membranous whorls by plasmodium berghei sporozoites.electron microscopy of sporozoites of the rodent malaria parasite, plasmodium berghei, reveals electron-dense multilaminate membranous whorls within components of the rhoptry-microneme complex after fixation with tannic acid in conjunction with glutaraldehyde. this multilaminate material, which has a dark line to dark line periodicity of approximately 5 nm, appears to be secreted from the sporozoite since it is also found adhering to the sporozoite's external surface. the material may function i ...19853925131
hepatic acid hydrolases of albino rats, mastomys natalensis and albino mice during plasmodium berghei infection.changes in liver acid hydrolase activities during the infection of albino rats, mastomys or mice with plasmodium berghei are described. b-glucosidase, b-galactosidase and n-acetyl-b-d-glucosaminidase exhibited widely different responses with acid phosphatase and cathepsin-b the least responsive and are likely to be causally related to immunity of animals.19853921400
novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity.novel hydroxynaphthoquinones are reported with outstanding efficacy against plasmodium, eimeria and theileria species. biochemical evidence is presented for the selective toxicity of these compounds being due to inhibition of parasite respiratory systems.19853920634
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