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muscular changes in lepromatous leprosy. 19704250383
bcg vaccination of children against leprosy. preliminary findings of the who-controlled trial in burma.the use of bcg vaccine in the prevention of leprosy has been one of the most important subjects of investigation in the field of leprology in the last 25 years. the action of the vaccine was for many years investigated by determining its effect on the lepromin reaction. field studies were later considered essential to determine whether bcg vaccination would be useful to leprosy contacts, to the child population probably exposed to infection, or to persons persistently lepromin-negative.the inter ...19704246110
recent advances in experimental leprosy. 19704244234
[an epidemiologist's viewpoint of leprosy]. 19684233037
[prospect of tuberculosis research. in reference to bacteriological aspect (author's transl)]. 19744218277
antimycobacterial antibodies in sera from patients throughout the clinico-pathological disease spectrum of leprosy. 19744215284
an investigation of takahashi's antitubercle phosphatide kaolin agglutination test (kat) in leprosy. 19744212936
the problem of cultivation of mycobacterium leprae. a review with criteria for evaluating recent experimental work.some criteria are presented to help evaluate papers appearing in the literature claiming successful cultivation of m. leprae either in the absence or in the presence of tissue-cultured cells. recently, electron microscopic studies have definitely shown m. leprae to belong to the genus mycobacterium and its division to occur through transverse section. a survey is given of the mycobacterial strains isolated in the last 10 years from leprosy lesions. these strains belong to taxonomically different ...19734212439
potential antileprotic agents. 3. inhibition of mycobacterial dihydrofolic reductase by 2,4-diamino-5-methyl-6-alkylquinazolines. 19744209923
detection of biological false positive syphilis serum reactions. 19744209642
immune response to mycobacterium leprae in indeterminate leprosy patients. 19734209177
[cross reactions in the serological diagnosis of chagas' disease and kala-azar including sera of tuberculous and leprous patients (author's transl)]. 19744207936
dopa metabolism by mycobacterium leprae: its implications in culture of the bacillus and chemotherapy of leprosy. 19734207691
bcg antibody profiles in tuberculoid and lepromatous leprosy.in sera from 12 patients with polar tuberculoid leprosy, 12 with subpolar tuberculoid leprosy, and 16 with lepromatous leprosy were demonstrated a total number of 125 anti-bcg precipitins by means of crossed immunoelectrophoresis with intermediate gel. up to 14 different precipitins were found in individual sera, and the complexity in antibody response was higher than previously realized. the specificity of 69% of the antibodies was defined, and these antibodies were titrated in three arbitrary ...19744207518
the growth of mycobacterium leprae in snakes. 19744207054
a century of progress in experimental leprosy. 19734205081
particulate nature of o-diphenoloxidase in mycobacterium leprae and assay of the enzyme by the radioisotope technique. 19734204390
[pathogenic mycobacteria in dermatology (author's transl)]. 19734203417
immunochemical characteristics and differentiation of nocardiae. 19734202913
immunological reactions of mycobacterium leprae and mycobacterium lepraemurium grown in cayman. 19734197246
[experience in the experimental study of leprosy]. 19734196880
[experience with the demonstration of mycobacterium leprae by the "thick drop" method according to markianos and nasal swab preparations]. 19684194413
studies of immune mechanisms in leprosy. ii quantitative relationships of igg, iga, and igm immunoglobulins. 19704192266
[new methods of experimental chemotherapy in leprosy]. 19694191849
biology of the mycobacterioses. a retrospective review of mycobacteria and the diseases they cause. 19684191743
an improved method for the fluorochrome staining of mycobacteria in tissues and smears. 19704190442
the evaluation of present antileprosy compounds. 19694190238
an electron microscope study of the band structure of the leprosy bacillus and other mycobacteria. 19694190094
studies on mott bacilli (mycobacteria other than tubercle bacilli). 19704190045
morphology of mycobacterium leprae in tissue sections. correlation with results of mouse foot pad inoculation. 19694187027
erythema nodosum leprosum: a clinical manifestation of the arthus phenomenon. 19694186599
immunoelectrophoretic study on the plasma protein of mice inoculated with several sorts of mycobacteria, in particular, with m. leprae and m. lepraemurium in the foot pad. 19674183179
[determination of the viability of leprosy mycobacteria by the cytochemical method]. 19674179208
staining conditions influencing morphological index of acid-fast bacilli. 19684178297
the surface structure of m. leprae. 19684177793
leprosy. 19684175655
drug resistance of mycobacterium leprae, particularly to dds. 19674173566
effect of ultraviolet irradiation on the acid-fastness of difficult to culture and unculturable mycobacteria. 19684170358
leprosy. a preliminary review of the experimental evaluation of drugs for the treatment of leprosy. 19674167891
microscopic, cultural and serologic studies on mycobacterium leprae and other mycobacteria isolated from leprosy patients. 19674165670
the lack of effect of methimazole therapy in lepromatous leprosy. reassessment by examination of bacterial morphology. 19674165669
morphology of mycobacterium leprae in tissue sections. 19674164667
observations on the morphological changes in myco. leprae in leprosy. 19654160467
[etiology of sarcoidosis in the light of a new histological demonstration method for mycobacteria]. 19654160204
[a new staining method for mycobacteria in tissue sections]. 19654158306
[100 years of mycobacterium leprae]. 19744154579
tenth international leprosy congress bergen, 1973. reports of committees. 19744152479
occurrence of mycobacterium leprae in arthropods. 19724146908
[microbiology of leprosy. behavior and staining affinities of hansen's bacillus in leprous lesions]. 19744143388
[effect of a uniform magnetic field on leukocytes. study of the leukocyte migration test in lepers]. 19744142862
acid mucopolysaccharide metabolism in leprosy. 1. storage of hyaluronic acid and its possible significance in the pathogenesis of leprosy.a histochemical analysis of 102 skin biopsies from a variety of leprosy types revealed the persistent presence of hyaluronic acid in lepra cells of lepromas. in contrast, the hyaluronic acid content of tuberculoid epithelioid cells showed a minimum amount of hyaluronic acid and hyaluronic acid tended to disappear from these granulomas as they aged. the macrophages of dimorphous leprosy occupied an intermediate position with respect to hyaluronic acid content and distribution, resembling the tube ...19744142476
morphological changes of mycobacterium leprae grown in mouse foot pads. 19744140172
fluorescent staining for mycobacterium leprae in tissue sections. comparison with fite-faraco procedure. 19744137671
electron microscope study of erythema nodosum leprosum. 19744137644
experimental chemotherapy in leprosy, then and now. 19734136732
intracellular growth of an obligatory parasite mycobacterium leprae. host bacterial interactions. 19744135832
leprosy: confirmation in the armadillo.bacteria isolated from lesions of lepromatoid leprosy in the armadillo were studied in comparison with mycobacterium leprae isolated directly from human lepromatous leprosy lesions. three methods were used to show that the bacteria from the lesions of the armadillo were identical to those of the human lesions: (i) extraction of the bacteria with pyridine and subsequent staining with various techniques, (ii) the competence in clearing bacilli (ccb) test, and (iii) the mitsuda test.19744133762
immunologic studies on leprosy. 2. antigenic studies of mycobacterium leprae. 19734131110
advances in the microbiology of m. leprae in the past century. 19734130571
leprosy-susceptibility testing of armadillos. 2. late cell and bacterial responses at inoculation site of living leprosy bacilli in 'resistant' armadillos. 19734129797
letter: culturing mycobacterium leprae in the dark. 19744129740
letter: thalidomine neuropathy and leprous neuritis. 19744129733
effect of prior oxidation on the acid-fastness of mycobacteria. 19734129032
comparison of the modes of spread and the incidence of tuberculosis and leprosy. 19744128836
quantitative evaluation of the progress of intracellular infection in vitro: incorporation of 3h-thymidine into deoxyribonucleic acid by mycobacterium leprae in cultivated blood monocytes.growth of intracellular parasites such as mycobacterium leprae in macrophages derived from human peripheral blood monocytes can be assessed by selective incorporation of [methyl-(3)h]thymidine into deoxyribonucleic acid of the bacterial cells. the radioactive precursor is not taken up by the host cells, and evidence has been presented for its incorporation into bacteria. the procedure is sensitive, reproducible, and highly quantitative.19744128631
electron microscopic study of the morphologic index. 19734126544
comments on the chemotherapy of leprosy as influenced by present knowledge of mycobacterium leprae. 19734120832
cytochemical reactions of human leprosy bacilli and mycobacteria: ultrastructural implications.leprosy bacilli harvested from freshly biopsied tissue from cases of lepromatous, borderline and histoid leprosy were, in conjunction with mycobacterium lepraemurium and representative mycobacteria, examined cytochemically with and without their pyridine-extractable acid-fastness. unlike the mycobacteria, unextracted leprosy bacilli failed to give a positive response to the periodic acid schiff test or to take up sudan black b, toluidine blue o, alkaline methylene blue or safranin o. once their ...19734120605
application of nyka's method for the staining of mycobacteria in leprous skin sections. 19734120112
a simple method for the differentiation of mycobacterium leprae from other mycobacteria through routine staining technics. 19724119114
studies on the antigenic specificity of mycobacterium leprae. ii. purification and immunological characterization of the soluble antigen in leprosy nodules. 19724119113
immunochemical identification of a defined antigen of mycobacterium leprae.an extract from purified mycobacterium leprae precipitated with sera from patients with tuberculosis, mycetoma, and leprosy and gave a band of identity with polysaccharide i from nocardia and mycobacteria.19724117882
[demonstration of hansen's bacillus during neuritis in leprosy]. 19724117525
mechanisms of reactions in leprosy. 19724115745
infection of murine striated muscle with mycobacterium leprae: a study by light and electron microscopy. 19724113797
modification of fite faraco staining for acid fast bacilli. 19714113757
stain techniques and the morphology of mycobacterium leprae. 19714113656
the morphological index. 19714113655
attempts at the cultivation of m. leprae in cell-free, semi-synthetic soft agar media. 19714112523
immunological analysis of mycobacterium leprae using cross-reactions with cytoplasmic antigens of the actinomycetales. 19724112239
prevention of leprosy. 19714105673
[misdiagnosed case of leprosy]. 19704105519
antileprosy drugs. 19714104273
elimination of the acid fastness but not the gram positivity of leprosy bacilli after extraction with pyridine.bacilli from a number of tissues excised from cases of lepromatous and borderline leprosy, unlike mycobacteria, were found to lose their acid-fastness after treatment with pyridine.19714102336
[immunologic specificity]. 19704100053
electron-transparent zone of mycobacteria may be a defence mechanism. 19704097724
a single skin lesion--an unusual presentation of lepromatous leprosy.lepromatous leprosy presenting as a solitary lesion with a high bacterial count is a rare occurrence. such a case has been followed at the national hansen's disease center, carville, louisiana, u.s.a., since 1977. the lesion was located on the left elbow and had been present for about nine months. the bacterial index in the lesion was 5+ and the morphological index was 0%, but slit-skin smears elsewhere were negative. the histopathology of the lesion was that of subpolar lepromatous leprosy, and ...19854086919
histology of the mitsuda reaction of healthy adults with no known contacts with leprosy patients.mitsuda tests were performed on 100 healthy adult brazilian males unrelated consanguineously to leprosy patients and with no known contacts with this disease. three lepromatous patients served as negative mitsuda controls. the lepromin employed was from mycobacterium leprae-infected armadillo tissue prepared according to who standards. clinical response to the lepromin inoculation was graded according to the recommendations of the vi international leprosy congress held in madrid (1953). the hist ...19854086917
leprosy in children one year of age and under.information obtained from a review of the literature, the united states armed forces institute of pathology files, and from a correspondence survey revealed a total of 91 infants one year of age and under in whom leprosy was diagnosed. biopsy confirmation was available on 19 infants, and in an additional 32 patients the diagnosis of leprosy was considered certain even though biopsy confirmation was not obtained. although the mother was probably the most common source of the infection (29 infants ...19854086915
isolation of phenolic glycolipid i from human lepromatous nodules. 19854045270
purification of phenolic glycolipid i from armadillo and human sources. 19854045269
inappropriate responses to mycobacterium leprae infections--c reactive protein in man and serum amyloid p in mice.in a study of c-reactive protein (crp) levels in the sera of 77 patients with leprosy, it was found that in the majority of newly diagnosed patients, the level was within the normal range for a healthy malaysian population. elevated levels did occur, but were usually found in patients with complications, and were more likely to occur in patients who had been receiving drug treatment for some time. this suggested that mycobacterium leprae infection by itself does not stimulate crp synthesis and c ...19854042426
biochemical alterations in the serum of armadillos (dasypus novemcinctus) infected with mycobacterium leprae. a preliminary report.armadillos (dasypus novemcinctus) were inoculated with mycobacterium leprae isolated from lepromas taken from untreated lepromatous patients or from the spleen of an armadillo previously infected with human m. leprae. the effect of the infection on the serum levels of lactic dehydrogenase (ldh), alkaline phosphatase (alkp), glutamate-oxalacetate (got) and glutamate-pyruvate (gpt) transaminases was investigated. in general, there was a good correlation between positive evidences of infection and ...19854020215
the mononuclear phagocyte system in granulomas.a comparison is made between immunologically induced and non-immunologically induced granulomas in guinea-pigs injected with metals (zirconium and aluminum) or with mycobacteria (bcg vaccine and mycobacterium leprae). immunological granulomas were characterized by epithelioid cells and fibrosis, whereas non-immunological granulomas contained phagocytosing macrophages with little evidence of fibroblast activation. epithelioid cells carry the same specific macrophage antigen as phagocytosing macro ...19854015981
cross-reactivity of antigens from the cytoplasm and cell walls of some corynebacteria and mycobacteria.leprosy-derived corynebacteria (ldc) are non-acid-fast organisms isolated from leprosy lesions in humans. in this study 20 antigens of native ldc cytoplasm were identified by immunoelectrophoresis, and autoclaving yielded the m1 component, which strongly cross-reacted with antigen 60 of mycobacterium bovis bcg (bacille calmette-guérin) and antigen 7 of mycobacterium leprae. the polysaccharide moiety of m1 was immunologically related to the ldc cell wall polysaccharide previously characterized as ...19853965589
[lysosome and leprosy bacilli]. 19853939304
a culture medium for cultivation of mycobacteria, probably mycobacterium leprae from mycobacterium leprae infected tissues.mycobacterium leprae suspensions were prepared from infected armadillos. the m. leprae cells were inoculated into culture media containing kh2po4 4.7. g. na2hpo4 2 g, sodium thioglycolate 1 g, (nh4)2so4 2 g, mgso4 0.1 g, ferric ammonium citrate 0.05 g, and lipoic acid (thioctic acid) 0.1 g in one liter distilled water. the solution was enriched with heat killed, sonicated leprosy derived mycobacterium x or crude mycobactin extract from m. phlei to contain + 0.2 micrograms mycobactin per 1 ml in ...19853938986
epidemiology of leprosy in relation to control (who technical report series no. 716 of 1985). part i. 19853938985
the role of interleukin-2 (il-2) in the specific unresponsiveness of lepromatous leprosy to mycobacterium leprae: studies in vitro and in vivo.the role of il-2 in the immunological deficiency of lepromatous leprosy patients towards mycobacterium leprae have been studied further. after initial stimulation with m. leprae + il-2, lepromatous lymphocytes could be restimulated with m. leprae alone. the specificity of the responses obtained varied. some patients gave a stronger response to bcg as compared to m. leprae, while in others a stronger response to m. leprae as compared to bcg was obtained. studies of the composition of lymphocytes ...19853936783
leucocyte migration inhibition response of mycobacterium habana with sensitized animals and cells from leprosy patients.response of mycobacterium habana sensitized mouse cells against habanin (sonicated extract) lepromin (dharmendra) and tuberculin has been studied in the leucocyte migration inhibition test. the homologous antigenic response has evoked maximum inhibition as compared to heterologous antigens but close antigenic association has also been observed with lepromin and tuberculin. with human cells from leprosy patients these antigens have evoked analogous response indicating cross immunogenicity of m. h ...19853935726
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