Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| effect of corynebacterium parvum on liver proliferation and regeneration. | 1979 | 421219 | |
| further observations on the inhibition of tumor growth by c. parvum with cyclophosphamide. vii. effect of treatment prior to primary tumor removal on the growth of distant tumor. | the present investigations were directed toward determining whether primary tumor manipulation prior to its removal is advantageous for the control of metastases and survival. studies were carried out to ascertain whether 1) there is justification for delaying surgical removal of a primary tumor to permit preoperative administration of cyclophosphamide (cy) and/or c. parvum (cp) and 2) there is an advantage to administering the immunotherapy directly into a primary tumor. after operation, in all ... | 1979 | 421172 |
| natural killer cells may be the only cells in normal mouse lymphoid cell populations endowed with cytolytic ability for antibody-coated tumour target cells. | mouse normal lymphoid cells were analysed as to their ability to perform in three cytolytic systems: ability to act as 'natural killer', nk, cells against a nk sensitive tumour target, yac; as effector cells against igg-coated 815 cells, or to function as effector cells against igg-coated crbc. nk activity and adcc against the igg-coated p815 cells were found to vary in parallel as affected by age, organ distribution and genotype of the effector cells. on the other hand, adcc against crbc was la ... | 1978 | 418499 |
| [potentiation of immunologic memory by corynebacterium parvum and its mechanism]. | immune response to bovine serum albumin (bsa) at dose of 2,50 mg/kg which is rather a weak immunogen in rabbits, when given intravenous was highly potentiated when the animals received a previous single intravenous infection of 2 mg/kg of c. parvum, followed by subsequent bsa anamnestic challenges for several months. thus, the antibody amounts synthesized following the 1st anamnestic injection (3 weeks) were 0,260 mg/ml in the control versus, 0,800 mg/ml in the c. parvum pretreated groups; follo ... | 1977 | 417841 |
| proposals for quality control methods of bacterial vaccines for immunostimulation. iii. effect of bcg and c. parvum on in vivo listeria clearance and tumor growth. | two quality control methods for bcg and c. parvum are described. first, in vivo macrophage dependent-spleen clearance of listeria monocytogenes in inbred b10lp mice. bcg and c. parvum were administered intravenously prior to listeria inoculation (a prophylactic model). conditions for enhanced listeria clearance including dose, route and time interval were described for each vaccine. next, a tumor model was developed: i.e. a fibrosarcoma, chemically induced by 20-methylcholanthrene in inbred balb ... | 1977 | 415924 |
| conditions favouring the selection of either specific or non specific c. parvum-mediated, systemic antitumour immunity in mice. | accumulated data suggest that one of two antitumour mechanisms of c. parvum may predominate depending on the route of injection of c. parvum and its distribution in relation to the tumour. after systemic c. parvum the mechanism is considered to be immunologically non specific (i.e. not requiring tumour specific antigens) and mediated by c. parvum activated macrophages. after local injection of c. parvum the interaction (direct or lymph node mediated) between c. parvum and tumour specific antigen ... | 1977 | 415921 |
| the effect of corynebacterium parvum on the proliferation of monocyte precursors in the bone marrow of mice. | the anti-tumour activity of c. parvum is thought to be mediated via the monocyte/macrophage system (scott, 1974). these cells originate from rapidly dividing precursors in the bone marrow and it might be at this level that c. parvum exerts its action. to test this hypothesis bone marrow t0 swiss mice has been cultured according to the method of bradley and metcalf (1966), which gives an index of the number of proliferating macrophage precursor cells at the time of sacrifice. experiments were set ... | 1977 | 415919 |
| effect of bcg and c. parvum on in vivo listeria clearance and tumor growth. comparative studies in normal and congenitally athymic (nude) mice. | clinically, it is important to know whether agents used for immunostimulation require the presence of functional thymus-derived (t) cells. previous studies showed that both bcg and c. parvum induced a macrophage-dependent enhanced in vivo listeria clearance and in vivo inhibition of a fibrosarcoma induced by 20-methylcholanthrene. these two models were re-evaluated in congenitally thymusless (nude or nu/nu) b10lp mice lacking functional t cells. in nu/nu mice, (1) bcg failed to enhance listeria ... | 1977 | 415917 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. v. comparison of the effects of tilorone hydrochloride, levamisole, methanol-soluble fraction of mycobacterium butyricum, bcg, and a nonviable aqueous ether extract of brucella abortus preparation in treatment of mice with tumors. | 1978 | 413929 | |
| effect of the combination of corynebacterium parvum and levamisole on murine tumors. | 1977 | 413718 | |
| reticulostimulating properties of killed vaccines of anaerobic coryneforms and other organisms. | vaccines prepared from 115 strains of anaerobic coryneforms and other organisms were tested in mice for their reticulostimulating ability as judged by the degree of spleen hypertrophy produced after ip injection. almost all vaccines caused a statistically significant increase in spleen weight, but the ability to produce spleen ratios (test mean wt:control mean wt) of 4 or more was confined to propionibacterium acnes and p. avidum strains. p. acnes, type ii, gave high spleen ratios more frequentl ... | 1977 | 411938 |
| antitumor activity of propionibacterium acnes (corynebacterium parvum) and isolated cytoplasmic fractions. | the tumor-inhibitory effect of an intralesional injection of propionibacterium acnes was of limited duration ("finite"). our model was the dba/2 syngeneic mouse injected with p815 mastocytoma cells (5 x 10(5)) into each rear footpad; only the left was treated, leaving the right as a "pseudometastasis." the finite effect occurred at approximately 21 days after the first treatment. subsequent i.p. treatments with p. acnes did not alter this effect, although they increased mean survival time. with ... | 1977 | 409491 |
| ovarian cancer: use of multiple modality programs involving surgery, radiation therapy and chemotherapy. | appreciating the past reports of effectiveness for various therapeutic modalities in ovarian cancer, the gynecologic oncology group activated eight protocols. three involved epithelial lesions with randomized multimodality trials alone or in combination. the other protocols were devoted to registration of rare tumor case reports. conclusions are still difficult to reach due to inconsistencies in pathologic diagnoses and deficiencies in radiation therapy, chemotherapy and surgery inherent in the ... | 1977 | 406985 |
| [radioprotection conferred by corynebacterium parvum against the lethality caused by x irradiation at sublethal and lethal doses in the mouse]. | intraperitoneal injection of corynebacterium parvum (c. parvum) into balb/c mice produces a protection against toxicity or lethality provoked by ionizing radiation (750 r and 950 r). survivals reaching nearly 90 days have been recorded. | 1977 | 406088 |
| bacteraemia in asymptomatic human subjects. | 1977 | 405961 | |
| diphtheroid osteomyelitis. | isolates of either corynebacterium diphtheriae or propionibacterium acnes from osteomyelitis are not necessarily contaminants, as shown by the cases of three patients who had bone and joint infections in which these organisms were pathogenic (one in pure culture and two in mixed cultures). previous operation or other factors that compromise host resistance create the setting for these opportunistic organisms. penicillin with or without streptomycin is the treatment of choice, but if penicillin o ... | 1977 | 405396 |
| bacteremia after upper gastrointestinal endoscopy. | during 24 months, 200 upper gastrointestinal endoscopies were performed on 193 patients. blood cultures were obtained before and five and 30 minutes after the procedure using thiol (50 ml) and trypticase soy broth (100 ml) media. the mean endoscopic time was 34 minutes. sixteen patients developed bacteremia (8%). twelve groups of microorganisms were detected in positive blood cultures: streptococcus (5 species), lactobacillus sp, veillonella alcalescens, staphylococcus aureus, staph epidermidis, ... | 1977 | 404974 |
| antitumor activity of a brucella abortus preparation. | mice injected intraperitoneally with sarcoma-180 cells develop ascites and eventually die. intraperitoneal injection of a nonviable, aqueous... ether-extracted brucella abortus preparation (bru-pel) as early as 7 days before or as late as 7 days after injection of tumor cells significantly inhibited development of ascites and protected against death. bru-pel was not effective if injected after ascites was grossly apparent. bru-pel was significantly more active than a corynebacterium parvum prepa ... | 1977 | 404249 |
| effect of bacterial products on inflammatory reactions in the dental pulp. | culture filtrates (extracellular components) and material obtained from disintegrated cells (intracellular components) of cultured plaque bacteria were studied for their capacity to induce inflammatory reactions in the dental pulp. class v cavities were prepared on the buccal surface of 94 teeth: 42 test and 52 control teeth in six adult monkeys. lyophilized bacterial components were sealed into the test cavities either alone or following an 8-h topical application of a solution of the same comp ... | 1977 | 402688 |
| a special report: four-year study of a boy with combined immune deficiency maintained in strict reverse isolation from birth. | a 4-year study of a boy with combined immune deficiency is presented, and the impact of this disease on various aspects of his growth and development is examined. there is no evidence of immune deficiency in either parent or in the genetic background on the maternal side. three children of a brother of the mother's father may have had immune deficiencies but two have grown to be teenagers with no problems. another died. at autopsy, however, lymph nodes appeared normal. the deceased older brother ... | 1977 | 401538 |
| effect of sensitization with propionibacterium acnes on the growth of listeria monocytogenes and treponema pallidum in rabbits. | sensitization of rabbits with propionibacterium acnes, a nonspecific stimulant of the reticuloendothelial system, was investigated as a means of enhancing resistance to treponema pallidum. a single i.v. dose of p. acnes given 3 or 7 days before challenge with listeria monocytogenes was capable of suppressing the growth of the heterologous organism, whereas a single i.v. dose 24 hr or 14 days before challenge was not. reactivation via i.v. elicitation with p. acnes 14 days after sensitization (1 ... | 1977 | 401511 |
| adjuvant intralesional and systemic corynebacterium parvum immunotherapy for surgically treated head and neck cancer. | 1978 | 401122 | |
| adjuvant immunotherapy. | because systemic spread occurs early in the growth of many malignancies, control of occult micrometastases must be an integral part of cancer treatment. for this reason, surgery and radiation therapy alone may fail to achieve a cure despite eradication of the primary tumor. chemotherapy is potent and systemic in its effects but kills tumor cells by first-order kinetics so the last cancer cell may not be eliminated. an agent is needed that can selectively attack and destroy small numbers of tumor ... | 1978 | 399764 |
| phagosome/lysosome fusion: a possible prerequisite for the enhancement of antibody responses in vitro by bcg, mycobacterium leprae and corynebacterium parvum. | primary in vitro antibody responses to srbc were suppressed in cultures prepared from the spleens of cba mice injected i.v. 20 days previously with 10(8) liver bcg. in contrast, cultures prepared from mice injected with dead bcg showed enhanced responses. in vitro spleen cell responses of the mice had returned to normal levels 4--6 weeks after their injection, but if dead bcg, m. leprae or c. parvum was added to the cultures, responses were enhanced. the enhancing effect of the added bacteria co ... | 1979 | 399339 |
| immune response modulation by colonization of germfree rats with propionibacterium acnes. | propionibacterium acnes (oral and/or parenteral administration) had a modulating effect on antibody-and cell-mediated immune responses of germfree (gf) and monoassociated (ma) rats. in conventionally reared rodents, parenteral injection of killed p. acnes stimulated the splenic plaque-forming cell response to sheep erythrocytes. however, in gf rats and in rats monoassociated with viable p. acnes, parenteral injection of killed p. acnes antigen inhibited the plaque-forming cell response to sheep ... | 1979 | 397928 |
| influence of tumor burden, tumor removal, immune stimulation, plasmapheresis on monocyte mobilization in cancer patients. | 1979 | 397757 | |
| human monocyte-mediated cytotoxicity to k-562 cells: activation by lymphokines. | human monocytes purified by adherence and prolonged in vitro monolayer culture were activated by supernatants of autologous lymphocytes stimulated with live bacillus calmette-guérin or killed corynebacterium parvum. activated monocytes expressed increased ability to lyse k-562 cells prelabelled with methyl-3h-thymidine in a 48 h assay. activation could be detected at a 1:64 dilution of lymphokine supernatants. target cell killing by activated monocytes was strongly influenced by the density of t ... | 1979 | 396667 |
| antitumor activity of cell-wall skeleton of propionibacterium acnes c7 in mice and guinea pigs. | the antitumor activity of the cell-wall skeleton (cws) of propionibacterium acnes c7 was examined by using transplantable tumors in syngeneic mice and in guinea pigs, and autochthonous tumors in mice. p. acnes-cws was shown to suppress the growth of fibrosarcomas, el4 leukemia, and mh134 hepatoma in syngeneic mice, and to regress the established tumors of a fibrosarcoma (mc104) in c57bl/6j mice, and a hepatoma (line-10) in strain-2 guinea pigs. the oil-attached p. acnes-cws mixed with fructose m ... | 1979 | 395008 |
| immunotherapy of lung cancer. i. review of clinical trials in non-small cell histologic types. | 1979 | 394836 | |
| chemoimmunotherapy (dtic and corynebacterium parvum) as adjuvant treatment in malignant melanoma. | sixty-one patients with stage i or ii (lymph node involvement) malignant melanoma were prospectively randomized into a control group receiving surgical treatment only (consisting of wide excision of primary and regional node dissection) and a group receiving the same surgical treatment plus adjuvant therapy with dtic and corynebacterium parvum. followup times ranged from 1 1/2 to 4 years. among the 29 patients in the surgical control group, there were five hematogenous recurrences and one region ... | 1979 | 393377 |
| the effect of acidic polysaccharides and prostaglandin-like substances isolated from propionibacterium acnes on granulocyte chemotaxis. | three acidic polysaccharide (ap) fractions and the prostaglandin-like substances (pls) isolated from p. acnes were investigated regarding their chemotactic activities on polymorphonuclear leukocytes. both ap's and pls induced a significant chemotatic response, which suggests their involvement in inflammatory acne vulgaris. | 1979 | 391585 |
| the effect of bcg-vaccination on vaccinia virus infections in mice. | pretreatment with bcg yielded a high degree of protection against experimental vaccinia virus infections in mice. corynebacterium parvum and aristolochia acid were less protective; other immunostimulants were ineffective. | 1979 | 389657 |
| [protection of mice with bacterial phospholipids against the lethal effect of frog virus 3 (fv 3) (author's transl)]. | a bacterial phospholipid extract (ebp) inoculated intraveinously at a dose of 1 mg/25 g body weight 30 hours before infection protects mice against the lethal effect of frog virus 3 (fv 3). the anti-fv 3 resistance produced by ebp requires protein synthesis during the period of pretreatment. the treatment with the bacterial extract has no effect on the inhibition of the macromolecular synthesis of the liver (rna and dna) which is observed at the beginning of the infection. however 48 hours after ... | 1979 | 388298 |
| prostaglandin-like substances in propionibacterium acnes. iii. differential contractile effects on smooth muscle layers of the human utero-tubal junction. | the biological activity of a lipid fraction extracted from p. acnes was tested on isolated smooth muscle strips from the human utero-tubal junction. the bioassay experiments support the concept that prostaglandin-like substances (pls) occur in p. acnes. however, in the bioassay system used, the effect of pls was different from that of pgf2 alpha and pgi2 but similar, although not identical, to that of arachidonic acid and pge2. | 1979 | 387431 |
| direct effects of corynebacterium parvum and bcg on human monocyte-mediated tumour cell cytostasis in vitro. | four strains of corynebacterium parvum (cp) and bcg induced low levels of cytostatic ability to a human tumour cell line in human monocytes when added directly to conventional monocyte cultures. the cytostatic ability induced by mediators from autologous lymphocytes stimulated with the same agents was greater than that produced by direct addition to monocytes. bcg was more efficient in stimulating lymphocyte dna-synthesis and lymphokine release than any of the cp strains tested. in order to test ... | 1979 | 386712 |
| c. parvum treatment of transplanted rat tumours of spontaneous origin. | c. parvum (wellcome cn6134) has been examined for suppression of a range of transplanted rat tumours of spontaneous origin. with five tumours (three mammary carcinomas and two fibrosarcomas) growth of comparatively high cell inocula (with respect to the minimum for growth in control rats) was suppressed by admixture with the vaccine. equivalent dry weights of glaxo, pasteur or connaught bcgs were relatively ineffective. intralesional injection of c. parvum into three three established tumours (t ... | 1979 | 385514 |
| cyclophosphamide plus 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (dtic) with or without corynebacterium parvum in metastatic malignant melanoma. | one hundred twenty patients with metastatic malignant melanoma were randomized to receive either cyclophosphamide, 600 mg/m2 iv, on day 1 plus dtic 200 mg/m2 iv days 1 through 5, or the same chemotherapy plus c. parvum 5 mg/m2 iv on day 8 and day 15. therapy was repeated every 21 days. although responses were observed in 13.8% of patients on cyclophosphamide plus dtic versus 25.5% of patients on cyclophosphamide plus dtic plus c. parvum, the median duration of remission was 15.6 weeks on chemoth ... | 1979 | 383276 |
| subcutaneous corynebacterium parvum in bladder cancer: a controlled study of its immunological effects. | fourteen out of 26 patients with invasive bladder cancer were randomly assigned to receive weekly subcutaneous injections of corynebacterium parvum (cp) in addition to standard treatment. peripheral blood t lymphocyte percentage, k cell activity, mitogen responsiveness, and monocyte and polymorph leucotaxis were measured at intervals over a period of 1 to 2 years. the only consistent difference between the cp-treatment patients and the controls was a slightly higher level of k cell activity in t ... | 1979 | 380732 |
| corynebacterium parvum: effects on the biochemistry of mouse serum and liver. | 1979 | 379402 | |
| effect of adriamycin and corynebacterium parvum in tumor-bearing mice: modulation of response to sheep red blood cells. | administration of adriamycin and corynebacterium parvum alone in c57bl/6j mice bearing lewis lung carcinoma stimulated the direct (19s) and indirect (7s) plaque-forming cell (pfc) response specific for sheep red blood cells. thus adriamycin appears to possess some immunostimulatory effect on tumor-bearing mice with much less effect than c. parvum alone. simultaneous administration of adriamycin and c. parvum decreased the pfc response compared to that for c. parvum alone. this decrease may indic ... | 1979 | 379400 |
| current state of clinical immunotherapy. | 1979 | 377611 | |
| in vitro killing of schistosomula of schistosoma mansoni by bcg and c. parvum-activated macrophages. | resistance to schistosoma mansoni infection in the mouse has been induced either specifically by a primary infection with this parasite or nonspecifically by a variety of immunostimulants such as bcg. in the present study we developed an in vitro system to examine the effector mechanism of nonspecifically induced resistance. activated macrophage monolayers obtained from bcg- or corynebacterium parvum treated mice killed a respective mean 32 +/- 6% and 48 +/- 5% of schistosomula after 24 hr incub ... | 1979 | 376723 |
| defective tumoricidal capacity of macrophages from a/j mice. i. characterization of the macrophage cytotoxic defect after in vivo and in vitro activation stimuli. | macrophages from a/j mice fail to develop tumoricidal activity after any of several in vivo or in vitro treatments that activate cells from c3h/hen mice. peritoneal macrophages from a/j mice treated i.p. with viable mycobacterium bovis, strain bcg, killed corynebacterium parvum, or pyran copolymer fail to develop in vitro tumoricidal activity; varying the numbers of macrophages from treated mice added to target cells, or the dose and time of treatment, or the treatment schedule of these in vivo ... | 1979 | 376720 |
| immunotherapy of solid tumor. | 1979 | 375448 | |
| [current status of immunotherapy of malignant tumors]. | 1979 | 367730 | |
| cocarcinogenesis. | 1979 | 367444 | |
| immunomodulation by corynebacterium parvum. 1. variable effects on anti-sheep erythrocyte antibody responses. | corynebacterium parvum injected i.p. 1--16 days prior to i.p. antigen inoculation virtually abolished both igm and igg primary responses to 1 x 10(8) srbc. the suppression was significantly marked at antigen doses ranging from 1 x 10(6)--1 x 10(9) srbc but not at 5 x 10(9) srbc. as little as 56 microgram c. parvum caused a marked suppression of the response to 1 x 10(8) srbc. in secondary responses c. parvum given either one day before priming with 1 x 10(8) srbc or one day before secondary chal ... | 1978 | 363603 |
| multimodal immunotherapy of primary gastrointestinal tumors in rats. 1. histologic correlation. | the effect of multimodal immunotherapy was studied in rats bearing primary gastrointestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. multimodal immune manipulation consisted of combinations of splenectomy, c. parvum, unblocking serum, unblocked lymphoid cells, and levamisole. such immunologic intervention resulted in significant inhibition of tumor growth, and their metastasis. ten of 10 untreated rats, 8 of 8 rats treated with splenectomy alone and 10 of 10 rats treated with nor ... | 1978 | 363250 |
| [immuno-chemotherapy in patients with disseminated metastasizing stage iii melanoma. randomized study with methyl-ccnu versus c. parvum plus methyl-ccnu]. | 34 patients with disseminated malignant melanoma (stage iii) were randomized to the following therapy groups: chemotherapy (meccnu, nsc 99441; 200 mg/m2, given orally every 8 weeks), or immuno-chemotherapy (1 mg corynebacterium parvum i.v., on days 1-4 + meccnu 200 mg/m2 on day 8, repeated every 7 weeks). total therapy response rate was 33%; total and partial remissions were achieved in 26% of the patients receiving chemotherapy, and in 40% under immuno-chemotherapy. interim life table analysis ... | 1978 | 362293 |
| the effect of intramural injection of immunotherapeutic agents on bladder histology and systemic humoral response. | bacillus calmette-guerín (bcg), corynebacterium parvum, and various mycobacterium fragments were injected intramurally into mouse bladders and the resulting systemic humoral stimulation and local histologic reactions were evaluated. c. parvum and methanol extracted residue of bcg elicited significant immunostimulation without producing irreversible bladder damage. the severe histologic disruption caused by bcg could be reduced by the antituberculus drug isoniazed without abrogating the humoral s ... | 1978 | 361626 |
| combination chemoimmunotherapy for extensive non-oat cell lung cancer. | in a prospective randomized trial, sc corynebacterium parvum (c. parvum) immunotherapy did not significantly affect the responses and survival of 49 non-oat cell lung cancer patients receiving isophosphamide and adriamycin chemotherapy. remissions (tumor regression greater than 50%) were seen in five of 23 patients receiving an intensive c. parvum schedule and in three of 26 patients receiving a nonintensive c. parvum schedule (22% versus 12%). median survival was 20 weeks for patients given int ... | 1978 | 356968 |
| immunity to transplantable carcinogen-induced fibrosarcomas in b2/b2 chickens. i. use of bacterial adjuvants in induction of immunity demonstrable in winn tests. | 1978 | 354799 | |
| chemo-immunotherapy for unresectable bronchogenic carcinoma. | seventy-nine patients with metastatic or unresectable bronchogenic carcinoma were treated with a regimen of combination chemotherapy which included methotrexate, oncovin (vincristine), cyclophosphamide, and adriamycin (moca), and were randomized to receive no additional therapy, immunotherapy with bacillus calmette-guérin, or immunotherapy with corynebacterium parvum (c. parvum). the response rate and estimated median survival time were 68% and 42 weeks in small cell carcinoma and 18% and 29 wee ... | 1978 | 350397 |
| combination chemotherapy plus methanol extracted residue of bacillus calmette-guérin or corynebacterium parvum in stage iii lung cancer. | seventy-six patients with stage iii bronchogenic carcinoma were treated with monthly adriamycin, cyclophosphamide, cis-dichlorodiammineplatinum(ii), and vincristine. in addition, they were randomized to receive either no immunotherapy, the methanol extracted residue of bacillus calmette-guérin (mer), or corynebacterium parvum (c. parvum). age, histology, extent of disease, prior therapy, and performance status were comparable in the three treatment groups. twelve patients (16%) died having recei ... | 1978 | 350388 |
| some examples of interactions between drugs in cancer chemotherapy. | drug combinations in cancer treatment are widely utilized because they frequently result in better therapeutic activity than the single treatments. the mechanism(s) by which this can be achieved may reside in an enhanced chemotherapeutic effect or in reduced toxicity, it being difficult to dissociate the two aspects. to underline this difficulty, experimental studies will be reported. a first example illustrates the interaction between phenobarbital and cyclophosphamide. depending on the schedul ... | 1978 | 348085 |
| immunotherapy from malignant disease. | 1978 | 348035 | |
| clinical immunotherapy experiences in the southeastern cancer study group. | the southeastern cancer study group has been particularly interested in the use of immunological adjuvants in the treatment of melanoma and acute myelogenous leukemia. a study of chemotherapy versus chemoimmunotherapy in randomly selected patients with metastatic malignant melanoma revealed no significant increase in either complete remissions or overall survival in the group receiving chemoimmunotherapy. preliminary results in a study involving maintenance of patients with acute myelogenous leu ... | 1977 | 344110 |
| c. parvum clinical protocols: prototypes and summary results in u. s. trials with wellcome coparvax. | clinical investigations utilizing wellcome c. parvum in cancer therapy number more than one hundred in multiple institutions. multiple diseases in various stages are being attacked by multi-modality therapy, making the role of immunotherapy very difficult to assess. fundamental laboratory observations have suggested ways of weaving non-specific with specific immunotherapy, and these with chemotherapy and radiation to yield maximum therapeutic benefit. current protocols include examples of the cr ... | 1977 | 344109 |
| randomized trial in advanced breast cancer using combination chemotherapy with or without c. parvum; preliminary results. | in a prospectively randomized cooperative study patients with metastatic breast cancer were treated with or without corynebacterium parvum (c.p.)5 mg/sc/m2 on day 1 in addition to cao/cmf (cyclophosphamid (c) 150 mg/m2/d per os x 5 d and adriamycine (a) 50 mg/m2 i.v. d 1 and oncovin (o) 1.0 mg/m2 i.v. d 1. 6 cao-cycles q 28 days later were followed by monthly cmf cycles q 28 d with cyclophosphamide (same dose), methotrexate 30 mg/m2 i.v. 1 and 5-fluorouracil 600 mg/m2 i.v. d 1). 76 patients ente ... | 1977 | 344108 |
| clinical studies with corynebacterium parvum. | in a pilot study twelve patients with malignant disease were treated with corynebacterium parvum. the clinical results were encouraging. a prospective randomised controlled clinical trial of c. parvum therapy in the treatment of patients with carcinoma of the bronchus began in august 1976. 22 pateints have been admitted to the trial and 11 treated with c. parvum. clinical progress is reported. radiological, haematological, biochemical and immunological measurements have been made and these resul ... | 1977 | 344105 |
| clinical experience in the use of c. parvum in the treatment of locally advanced carcinoma of the breast. | twenty-one patients with locally advanced breast cancer which had failed to respond to conventional therapy have been treated by infusion of c. parvum (strain cn 6134, wellcome research laboratories) in 5% dextrose. thirteen patients had a single dose of 15 mg. c. parvum over 4 h and 8 patients received 5 daily infusions of 4 mg c. parvum over 1 h. in 3 patients there was some evidence of tumour regression. pyrexia, often associated with rigors, headaches, vomiting and variations in blood pressu ... | 1977 | 344104 |
| clinical trial with corynebacterium parvum. | corynebacterium parvum was administered to sixteen patients with malignant tumors submitted to repeated chemotherapy courses. a total of 428 injections of c. parvum at a dose of 3.5 mg/m2 in weekly, biweekly and monthly administration was given between the chemotherapy courses. injection of c. parvum was followed by fever and local pain in 15/16 patients. three patients presented a local ulceration during the initial period of weekly injections. splenomegaly was observed after the second month o ... | 1977 | 344103 |
| a phase i study of a multi-modal schedule with corynebacterium parvum. | a phase i study of an immuno-chemotherapy regime was carried out using c. parvum as an immune-modulator. 14 women were studied. all received doses of c. parvum ranging from 2.5 mg to 21 mg administered in 1 litre of dextrose saline over 4 h. no evidence of tumour enhancement was observed. | 1977 | 344102 |
| monitoring of a multi-modal schedule for the treatment of disseminated breast cancer. | 39 women and 1 man have been monitored by sequential cea, immunoglobulin, lymphocyte and monocyte readings, hydroxyproline excretion, scans and x-rays. cea is shown to be a useful monitor of disease. the significance of the lymphocyte counts is discussed. | 1977 | 344101 |
| various modalities of local administration of bacterial immunostimulants in transplantable rat tumours and in primitive methylcholanthrene mouse tumours. | the frequent use of intra-lesional injection of bacterial immunostimulants is hampered by apparent rarity of susceptible tumours, absence of therapeutic effect on large tumours, lack of variety of experimental models, eventual traumatism which is feared in case of intra-lesional, and injection in visceral cancers. (1) methylcholanthrene induced primitive tumours in mice are more frequently susceptible when the carcinogen induction dosage is low (0.01 mg). (2) using transplantable rat tumours, on ... | 1977 | 344100 |
| host responses in adjuvant contact suppression of experimental rat tumours. | bcg (glaxo) and c. parvum (wellcome cn 6134) have been examined for suppression of growth of a range of syngeneically transplanted rat tumours, both carcinogen-induced and of spontaneous origin. treatment by locally applied adjuvant controlled growth of both immunogenic and non-immunogenic tumours, and the response to highly immunogenic tumours was not abolished by host immunosuppression with whole body irradiation known to abrogate induction of tumour-specific immunity. in addition, rat tumour ... | 1977 | 344098 |
| immunological adjuvants in cancer immunotherapy. | 1977 | 344097 | |
| the cells involved in the modification of the in vitro immune response by corynebacterium parvum (c. parvum). | 1977 | 344096 | |
| antitumor activity of corynebacterium parvum. | 1978 | 343523 | |
| suppression of natural killer cell cytotoxicity by splenocytes from corynebacterium parvum-injected, bone marrow-tolerant, and infant mice. | natural killer (nk) cell cytotoxicity to yac-1 lymphoma was investigated in mice tolerant to bone marrow grafts (bm-tolerant), corynebacterium parvum- (c. parvum) treated mice, and infant mice. also the comparison was made between the nk cell and the hemopoietic-resistance effector (hr-e) cells. it was found that the bm-tolerant mice and c. parvum-treated mice showed either no or markedly decreased nk cell cytotoxicity. these mice were also nonresponders to bone marrow grafts in vivo. the lack o ... | 1978 | 342602 |
| mechanism of nonspecific macrophage-mediated cytotoxicity: evidence for lack of dependence upon oxygen. | peritoneal macrophages elicited in c3h/hj mice by the i.p. injection of corynebacterium parvum were cytotoxic to allogeneic virus-transformed fibroblasts in vitro. cytotoxicity was demonstrated in a morphologic (plaque) assay, and quantitated by measuring macrophage-mediated inhibition of incorporation of 3h-thymidine by the target cells. the cytotoxic effect was well established by 6 hr of macrophage-fibroblast interaction, and was retained in cultures from which the supernatant was removed bef ... | 1978 | 340584 |
| the reversal of established enhancement in rat cardiac allografts. | established enhancement in rat cardiac allografts was challenged in a variety of ways in an attempt to provoke rejection. incompatible skin grafts, injections of sensitised lymphocytes, and the administration of the macrophage-stimulating agent corynebacterium parvum proved ineffective. however, levamisole, which stimulates both macrophages and sensitised lymphocytes, caused rejection in four of a group of six as rats bearing enhanced (august x as)f1 hybrid heart allografts. a combination of c. ... | 1977 | 339437 |
| immunotherapy in the treatment of cancer. | this article is a review of immunotherapy in the treatment of cancer incorporating the history of immunotherapy in the nineteenth and twentieth centuries, assessment of the techniques currently in use and of possible future developments. although immunotherapy is not established as a therapeutic technique, evidence suggests that the immune response does influence the development of neoplastic cells. a better understanding of the immune response and its control may lead to the production of effic ... | 1977 | 337486 |
| mechanism of corynebacterium parvum anti-tumour activity. ii. protective effect in t-cell-deprived mice. | the natural resistance to syngeneic mammary carcinoma was reduced by thymectomy alone in adult c3h mice or in mice thymectomized, lethally irradiated and restored with bone-marrow cells (tx rb). the protective effect of c. parvum was not modified by adult thymectomy but it was reduced in tx rb mice. the injection of thymic cells to tx rb mice or the elimination of t cell precursors in bone-marrow cells injected in tx rb mice did not increase the protective effect of c. parvum. these results were ... | 1977 | 334678 |
| [porphyrinsynthesis by propionibacterium acnes (author's transl)]. | strains of p.a. were isolated from seborrheic filaments from 11 persons and investigated according to their production of porphyrins. after growing the organisms during a 5 resp. 10 days cultivation period on solid as well as in liquid culture medium the quantity and quality of the bacterial porphyrins were determined. there existed intense variations in quantity not only when the special strains were compared with each other but also when the same strains were treated with different preparation ... | 1977 | 334087 |
| corynebacterium parvum as the priming agent in the production of tumor necrosis factor in the mouse. | 1977 | 333124 | |
| canine migration inhibitory factor: effect of corynebacterium parvum administration. | peripheral blood lymphocytes from dogs sensitized to streptolysin o (slo) were assayed for migration inhibitory factor (mif) production by the indirect mif test, using guinea pig peritoneal exudate cells as the source of macrophages. a specific direct correlation was established between the degree of inhibition of migration and the concentration of slo-stimulated supernatants from lymphocyte cultures (slo-s) of untreated normal dogs. undiluted slo-s inhibited migration by 66.8%, whereas a diluti ... | 1977 | 332636 |
| management of metastatic breast cancer. | 1977 | 330978 | |
| in vivo transfer of antitumor activity by peritoneal exudate cells from mice treated with corynebacterium parvum: reduced effect in irradiated recipients. | 1977 | 330869 | |
| plasmodium yoelii and plasmodium vinckei: the effects of nonspecific immunostimulation on murine malaria. | 1977 | 330190 | |
| penetration of cells into millipore diffusion chambers. | 1977 | 330180 | |
| mechanisms of action of immunopotentiating agents in cancer therapy. | 1977 | 329658 | |
| adjuvant protection against bacterial infection in granulocytopenic mice. | the hypothesis that the induction of nonspecific resistance to infection by immunostimulation prior to drug-induced granulocytopenia would afford increased protection to subsequent bacterial challenge was tested in a murine model of infection with pseudomonas aeruginosa or staphylococcus aureus in mice rendered granulocytopenic with cyclophosphamide. prior intraperitoneal immunostimulation of mice with complete freund's adjuvant (cfa) or mycobacterium bovis (bacille calmette-guèrin; bcg) increas ... | 1977 | 328788 |
| complement activation by the alternative pathway and macrophage enzyme secretion in the pathogenesis of chronic inflammation. | a number of stimuli known to induce acid hydrolase secretion from cultured macrophages were examined for their ability to activate c3 via the alternative pathway of the complement system. loss of haemolytically active c3 was checked in normal and c4-deficient guinea-pig serum. for comparison the interactions of cultured macrophages with other agents well known as potent activators of the alternative pathway of the complement system have been investigated. as judged by their activity in these ass ... | 1977 | 328387 |
| superoxide dismutase in anaerobic bacteria of clinical significance. | twenty-two anaerobic bacteria isolated from infected sites and normal fecal flora were assayed for superoxide dismutase (sod). the organisms were also classified according to their oxygen tolerance into aerotolerant, intermediate, and extremely oxygen-sensitive groups. there was a correlation between the enzyme level and the oxygen tolerance, in that the aerotolerant and intermediate organisms had sod, whereas the extremely oxygen-sensitive isolates had low or undetectable enzyme. among the oxyg ... | 1977 | 326669 |
| resistance to parental, allogeneic and xenogeneic hemopoietic grafts in irradiated mice. | 1977 | 326573 | |
| adjuvant activity of propionibacterium acnes isolated from the human oral cavity. | 1977 | 326235 | |
| immunologic aspects of cancer chemotherapy. | 1977 | 326163 | |
| [growth of non-sporing anaerobes in an oxygen-free blood culture system (author's transl)]. | the efficacy of the commercially available vacutainer blood culture system to support the growth of non-sporing anaerobes was compared with two laboratory-prepared blood culture media (supplemented thioglycollate medium and brain heart infusion). the media were inoculated with 10, 100 and 1000 organisms of the species tested, and the number of colony-forming units was determined at intervals of 8-10 hrs. analogous experiments were performed with batches of the media to which 10% vol/vol of human ... | 1977 | 325956 |
| effect of anti-thymocyte serum, anti-macrophage serum, and latex particles on the therapeutic efficacy of bcg or corynebacterium liquefaciens (propionibacterium acnes c7) in syngeneic mice. | in a syngeneic mouse-tumor system, anti-thymocyte serum, anti-macrophage serum, and latex particles were used for a comparative study of the immunotherapeutic efficacy of intradermal inoculation of tumor cell-bcg and tumor cell-corynebacterium liquefaciens (=propionibacterium acnes c7) vaccines. anti-thymocyte serum treatment nullified suppression of tumor mediated by bcg (living and nonliving) and living c. liquefaciens. however, the effect of nonliving c. liquefaciens was not affected so much ... | 1977 | 324858 |
| effects of bcg and corynebacterium parvum on the haemopoietic precursor cells in continuously irradiated mice: possible mechanisms of action in immunotherapy. | 1977 | 324769 | |
| immunological properties of propionibacterium acnes. i. potentiation and suppression on antibody response to sheep and hamster erythrocytes in mice. | adjuvant activity of phenol-treated cells of propionibacterium acnes c-7 in antibody response was investigated in icr mice. simultaneous administration (day 0) of p. acnes (i.p.) and sheep red blood cells (srbc) (i.v.) enhanced the formation of direct plaque-forming cells (pfc) on days 2, and the formation of indirect pfc response on day 7 and thereafter. conversely, pretreatment from 11 to 14 days before antigen injection suppressed markedly the antibody response. the potentiation and the suppr ... | 1977 | 323645 |
| functional heterogeneity in macrophages activated by corynebacterium parvum: characterization of subpopulations with different activities in promoting immune responses and suppressing tumor cell growth. | peritoneal cells (pec) from mice injected i.p. with heat-killed corynebacterium parvum (cp) showed enhanced immunostimulatory (accessor or a cell) activity as measured by their ability to restore the immune responsiveness of nonadherent spleen cells to sheep erythrocytes (srbc) and polymeric flagellin (pol) of salmonella adelaide in vitro. this was true whether the pec and nonadherent spleen cells were in direct contact or separated by a cell-impermeable membrane which allowed the free passage o ... | 1977 | 323353 |
| [treatment of solid tumours by intratumoral injection of immunostimulants]. | intra-lesional injections of immunostimulants--bcg or corynebacterium parpum--induced a local cure of the mcfifj2(s) tumour and a remote therapeutic effect. when applied to rats multigrafted with the mcfifi2(s) tumour, local and distant cures were obtained in some situations. this indicates the likely intervention of a specific immune mechanism. quantilating the pulmonary metastasis in combination with local treatment of lewis mouse tumours showed that bcg plus c. parvum injected into the tumour ... | 1977 | 322574 |
| immunotherapy of cancer. | clinical studies have indicated a close relationship between immunological competency and the growth of human cancer. studies in animal systems have indicated that immunological mechanisms are important in host-tumor existence. a number of agents are in the process of being evaluated for their immunotherapeutic potential in patients with cancer. these include levamisole, bacille calmette guérin (bcg) and corynebacterium parvum. while the precise role of these agents in the treatment of human mal ... | 1977 | 322390 |
| tumor immunology and immunotherapy. | tumor cells contain a variety of antigens, including tumor associated antigens. the tumor associated antigens can be clinically useful as markers for detection of cancer and some may also mediate host resistance against tumor growth. much emphasis has been placed on the detection of circulating tumor associated markers, with radioimmunoassays for carcinoembryonic antigen (cea) being extensively utilized. at present, cea does not appear to be promising for initial detection of cancer, but may fin ... | 1977 | 321899 |
| a comparison of pyrogenicity and related properties seen in a suspension of corynebacterium parvum and a gramnegative organism. | when the pyrogenic properties of c. parvum and a gramnegative organism, s. typhimurium, were compared it was found that the onset of the pyrogenic response to c. parvum was delayed relative to that of s. typhimurium and that secondary responses rarely occurred. in further experiments the interaction of c. parvum and s. typhimurium was studied. although synergism was not demonstrated, the kinetics of the response to mixtures of the two vaccines was anomalous while pre-treatment of rabbits with c. ... | 1977 | 320069 |
| inhibitory effect of propionibacterium acnes on the growth on syngeneic tumor transplants in nude mice. | 1979 | 318050 | |
| response of lympho-hemopoietic tissue to corynebacterium parvum by study of dna enzymes and h3-tdr metabolism. | the effects of corynebacterium parvum on the lymphohemopoietic tissues of mice was investigated by h3-tdr metabolism, organ weights, dna-polymerase-alpha activity and terminal deoxynucleotidyl transferase (tdt) activity. marked increase in spleen size occurred. the increase in size was accompanied by increases in dna-p-alpha activity and h3tdr uptake. this indicated that the spleen was a major site of cell proliferation and of increase in population size after c. parvum stimulation. thymus and b ... | 1979 | 317898 |
| inhibition of host resistance by nutritional hypercholesteremia. | previous experiments showed that nutritionally induced hypercholesteremia in mice caused an increase in susceptibility to coxsackievirus b, with a marked suppression of cellular infiltrates in infected tissues and an increased mortality. the present studies demonstrated that a hypercholesteremic diet was associated with an inhibition in host resistance as measured by susceptibility to listeria monocytogenes infection and the growth of two transplanted syngeneic murine tumors. moreover, the abili ... | 1979 | 317596 |