Publications

thymidine kinase as a negative selectable marker in leishmania major.		1992	1315415
cellular responses of vervet monkeys (cercopithecus aethiops) experimentally infected with leishmania major.		1992	1307757
experimental chemotherapy of leishmaniasis with adenosine analogue formycin a, in combination with inhibitor of nucleoside transport, nitrobenzylthioinosinate.	a single dose of the adenosine analogue formycin a (foa) (20 mg/kg), combined with nitrobenzyl mercaptopurine ribonucleoside 5'-monophosphate (nbmpr-p) (10 mg/kg), a prodrug of nitrobenzylthioinosine (nbmpr), was effective in reducing the size of the foot pad lesions from 7.4 +/- 0.2 to 3.9 +/- 0.2 of syrian golden hamsters infected with leishmania major. there was a statistical difference (p < 0.01) in the size of the foot pad by the fifth day between the infected groups that received treatment ...	1992	1306154
ecoepidemiology of leishmaniases in syria. 3. leishmania major infection in psammomys obesus provides clues to life history of the rodent and possible control measures.	collections of psammomys obesus from near damascus, syria in may 1990 and november 1991 contained animals of all ages. both series had a high prevalence of leishmania major infection. lesions were small in november and large in may. assuming the two collections were representative of typical years, it is inferred that the breeding season is between october and may: there is high winter mortality of animals born early in the breeding season, but high survival of their parents, and there is high m ...	1992	1301732
[leishmania major mon-117, an agent of cutaneous leishmaniasis in mauritania].	the causative agent of cutaneous leishmaniasis in mauritania is identified for the first time as leishmania major mon-117, a new zymodeme closely related to mon-26. the authors point out the need to study this previously unknown focus.	1992	1290377
axenic cultivation of amastigotes of leishmania donovani and leishmania major and their infectivity.	two clones of promastigotes, one of leishmania donovani and one of l. major, and an uncloned stock of l. major were axenically transformed to heat-shock amastigotes, at 35 and 37 degrees c, respectively. of the four different culture media tested, a relatively cheap, liquid medium, rblm, was found to be the best, both for the transformation of the promastigotes and the serial, axenic cultivation of the amastigotes. in an experiment of 30 days duration, serial cultivation, in an atmosphere with 5 ...	1992	1288430
leishmania major: bacterial contamination of cutaneous lesions in experimental animals.	no bacterial contamination has been demonstrated in cutaneous leishmaniasis (cl) nodule and in lesions caused by leishmania major in balb/c mice up to 20 days after infection. however, although many phagocytic cells (polymorphonuclear leukocytes and macrophages) were present in the cl lesion, 80% of the lesions showed bacterial contamination that developed within the first 70 days of infection. topical treatment of the lesion with an ointment containing 15% paromomycin and 12% methylbenzethonium ...	1992	1286954
leishmaniasis and the arabian gulf.		1992	1285153
ecological causes of predominance of some mammals as reservoirs of leishmania tropica major in turanian deserts.		1975	1158296
[biological properties of promastigotes of leishmania having undergone lyophilization].	materials are presented of a comparative study of morphological and cultural properties and virulence of liophylized cultures of leishmania tropica major after their rehydration or after a long passage on the nnn medium. results of investigations of two initial strains and three substrains obtained after the recovery of liophylized cultures have shown that liophylization does not reduce essentially the initial strain virulence. the strains undergone liophylization and passed repeatedly on the nn ...	1976	1026908
[fate of the promastigotes of leishmania tropica major and l. gymnodactyli in the body of phlebotomus papatasi under conditions of a mixed infection].	experimental infection of males and females of phlebotomus papatasi sc. with leishmania tropica major from man and l. gimnodactyli from agama sanguinolenta was carried out in order to obtain mixed infection. sand flies from the laboratory culture were successively infected with promastigotes of each species of leishmania by means of compulsory dose feeding according to alekseev's method. for identification of leishmania cultures isolated from experimentally infected sand flies alder's serologica ...	1976	940687
[effect of the dose of leishmania tropica major culture on antibody formation in mice with cutaneous leishmaniasis].		1977	927378
[factors causing death of mice infected with the culture of leishmania tropica major].		1977	927365
[natural foci of zoonotic cutaneous leishmaniasis in central asia and the problems of the district division of the geographical range of leishmania major].		1978	672776
generalized infection and lack of delayed hypersensitivity in balb/c mice infected with leishmania tropica major.	the susceptibility of a few strains of mice to a subcutaneous injection of leishmania tropica major, the causative agent of cutaneous leishmaniasis in humans, was studied. the infection in six strains (cba, akr/j, akr/cu, c57bl/6, a/j, and c3h) remained cutaneous, and the animals recovered within 3 to 4 months. in contast, the infection in balb/c became generalized and killed 1005 of infected animals. intraperitoneal injection of infected liver of balb/c to a/j and syngeneic mice produced a leth ...	1979	546790
isoenzyme characterization of leishmania species from iraq.	leishmaniasis in iraq takes both the visceral and cutaneous forms. the causative organisms are identified according to the electrophoretic variation of the enzymes mdh, gpi, 6pgd, pgm and idh. the 37 visceral stocks investigated fall into two groups which differ only with respect to gpi. the six cutaneous stocks were divided into three groups. group 3 represents leishmania major, while groups 4 and 5 refer to l. tropica showing intraspecific variation with regard to 6pgd.	1979	539855
isolation of leishmania major from mastomys erythroleucus and tatera gambiana in senegal (west africa).		1979	534447
[characteristics of formation of humoral antibodies in albino mice in experimental infection with leishmania tropica major and leishmania tropica minor].		1977	412046
[distribution characteristics of leishmania tropica major strains of differing virulence in natural and territorial complexes of the murgab eco-area (southeastern turkmenistan)].	in september--october of 1973 and 1974 263 specimens of rhombomys opimus were shot in the territory of the murghab stationar. the seeding of the material (a piece of tissue) from all animals into nnn medium was done. 9 strains of l. tropica major were isolated from this material the virulence of which was studied on 2.5--3 months--old golden hamsters, cricetus auratus. differences in the virulence of the isolated strains according to their natural-territorial complexes are shown. these differenc ...	1977	145568
[virulent properties of leishmania tropica major strains isolated from sandflies in the subzone of the northern deserts].	on the territory of the karakalpak assr the infection of sand flies ph. papatasi, ph. caucasicus, ph. andrejevi and ph. monogolensis with the agent l. tropica major ammounts, on the average, to 39.3%. the virulence of 88 investigated strains of leishmania for white mice estimated by their infection and the duration of incubation was found to be different; one half of the strains had high, one third--average, and the other strains--low virulence.	1976	134342
specificity of transfer factor. in vitro lymphoblast transformation of peripheral lymphocytes to leishmania major antigen in the presence of transfer factor.	the in vivo and in vitro demonstration of specificity of transfer factor (tf) has so far been hampered by lack of a suitable antigen. the host partiality of leishmania suggested that in the case of leishmania antigen it should be possible to obtain lymphocytes of both donors and recipients of tf which were either sensitized or truly virgin. lymphoblast transformation of normal donor lymphocytes to leishmania major antigen (lma) was therefore measured in the presence of tf prepared from donors wi ...	1977	74087