Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| growth inhibiting and promoting effects of amino acids and glucose of five strains of m. leprae and their growth on an inhibitor-free medium. | 1973 | 4591322 | |
| conservation of mycobacterium leprae in liquid nitrogen. | 1973 | 4590989 | |
| stimulating effect of pyruvate on the growth of mycobacterium leprae in cell-free, semisynthetic, soft agar medium. | a bacterial suspension prepared from a nodule from a patient with lepromatous leprosy was inoculated into the cell-free, semisynthetic, semiliquid agar medium m-y 11d-modified from the authors' medium m-y 1c by omitting glycerol and adding pyruvate-and incubated at 37 degrees c. the growth of the organism was stimulated so markedly that after about 50 weeks' incubation of the primary culture microcolonies could be seen floating in the agar layer as tiny white particles, while the medium fluid as ... | 1973 | 4590553 |
| evidence that the mechanism of immunological tolerance ("central failure") is operative in the lack of host resistance in lepromatous leprosy. | 1972 | 4590279 | |
| the internal anatomy of nerve trunks in relation to the neural lesions of leprosy. observations on pathology, symptomatology and treatment. | 1973 | 4589950 | |
| leprosy in the armadillo: new model for biomedical research. | eight of twenty armadillos (dasypus novemcinctus l.) developed severe lepromatous leprosy 3 to 3.5 years after inoculation with viable mycobacterium leprae. a total of 988 grams of lepromas containing an estimated 15 to 20 grams of leprosy bacilli has been harvested from these animals. the large amounts of material now available will permit in-depth studies of the biochemistry and metabolism of the leprosy bacillus, and the animal model should make possible definitive studies on the immunology, ... | 1974 | 4589901 |
| potential antileprotic agents. 2. inhibition of mycobacterial dihydrofolic reductase. | 1974 | 4585973 | |
| potential antileprotic agents. 1. inhibition of a model mycobacterial system by diaryl sulfones. | 1974 | 4585972 | |
| a histological study of liver lesions in leprosy. | 1973 | 4585597 | |
| editorial: leprous leukoderma. | 1973 | 4585247 | |
| lepra cells in synovial fluid of a patient with erythema nodosum leprosum. | 1973 | 4585102 | |
| the nasal mucus in leprosy. | 1973 | 4584261 | |
| autotrophism of an "intracellular parasite" mycobacterium leprae. | 1973 | 4583838 | |
| immune responsiveness to mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy. | 1973 | 4583777 | |
| mechanism of nerve destruction in tuberculoid-borderline leprosy. an electron-microscopic study. | 1973 | 4582968 | |
| the effect of neonatal thymectomy on mycobacterium leprae infection in mice. | 1973 | 4582839 | |
| in vitro behavior of blood derived macrophages against killed m. leprae. | 1973 | 4582838 | |
| a rapid identification test for mycobacterium leprae. | 1973 | 4582837 | |
| editorial by the president of the international leprosy association. | 1973 | 4582835 | |
| spheroidal bodies and globi of human leprosy. | 1973 | 4582380 | |
| ulcerating lepromatous leprosy in a patient with dapsone-resistant mycobacterium leprae. | 1973 | 4582180 | |
| the hansen centenary. 1. hansen, bergen and leprosy. | 1973 | 4582179 | |
| how do leprosy bacilli leave the body? | 1973 | 4582178 | |
| behavior of mycobacterium leprae in human macrophages in vitro. | attempts have been made to cultivate mycobacterium leprae in human macrophages in vitro. in 27 out of 55 experiments a two- to ninefold increase (mean 2.31 +/- 1.46) in acid-fast organisms were observed over a period of 1.5 to 3 months of cultivation. no such increase was observed with heat-killed bacilli (mean fold increase 0.88 +/- 0.19). macrophages were necessary for obtaining increases. no multiplication was observed on artificial media. a close correlation between increases of acid-fast or ... | 1973 | 4581011 |
| subclinical infection in leprosy. | lymphocyte transformation has been used to study the immune response to mycobacterium leprae among contacts and non-contacts of leprosy patients. of 26 subjects living in a leprosy endemic area for less than two months none responded to m. leprae; 24% of subjects who had lived in an endemic area for more than a year gave a positive response to m. leprae; more than 50% of individuals with occupational contact of leprosy for more than a year responded; and about 50% of contacts of tuberculoid and ... | 1973 | 4580217 |
| demonstration of mycobacterium leprae and its viability in the peripheral blood of leprosy patients. | 1972 | 4579979 | |
| the effect of antibacterial drugs on the ultrastructure of mycobacterium leprae in human skin. | 1972 | 4579978 | |
| [differential diagnosis of mycobacterium leprae using in-vitro studies in the human macrophage]. | 1973 | 4578753 | |
| [the relationship between inoculation with human leprous bacilli in mice, and body temperature]. | 1972 | 4578506 | |
| g. armauer hansen. | 1973 | 4575467 | |
| acute adenopathy in a young man. | 1973 | 4575466 | |
| [active growth of mycobacterium leprae within necrotic tissues]. | 1972 | 4574308 | |
| absence of enhancing effect of trimethoprim on the activity of a sulfonamide against mycobacterium leprae. | 1972 | 4574275 | |
| attempts to cultivate and determine the maximum period of viability of mycobacterium leprae in tissue culture. | 1972 | 4574271 | |
| immune response to m. leprae of healthy leprosy contacts. | 1972 | 4574270 | |
| attempts to establish the armadillo (dasypus novemcinctus linn.) as a model for the study of leprosy. ii. histopathologic and bacteriologic post-mortem findings in lepromatoid leprosy in the armadillo. | 1972 | 4574269 | |
| correlation of laboratory and clinical data during treatment of leprosy. | 1972 | 4574223 | |
| leprosy-susceptibility testing of armadillos. 1. cellular responses to intradermally inoculated heat-killed leprosy bacilli. | 1973 | 4572646 | |
| effect of surface active agents and semisolid agar media on the growth of mycobacterium leprae. | 1973 | 4572215 | |
| the microscope and leprosy. | 1973 | 4571465 | |
| hansen's bacillus. gerhard henrik armauer hansen (1841-1912). | 1973 | 4571363 | |
| the distribution of mycobacterium leprae in different structures of the skin. | 1972 | 4571242 | |
| infectivity of leprosy bacilli from bone marrow and liver of patients with lepromatous leprosy. | 1972 | 4571241 | |
| [mycobacterium leprae. a 100-years recollection]. | 1973 | 4570663 | |
| [leprosy as an immunological model]. | 1973 | 4570661 | |
| growth inhibitors and promoters acting on mycobacterium leprae. | 1972 | 4570283 | |
| early response of mouse foot pads to mycobacterium laprae. | the purpose of these experiments was to study the early response of mouse foot pads to mycobacterium leprae. to accomplish this, mice were inoculated in both foot pads with large and small numbers of organisms. the animals were sacrificed at intervals from 2 hr to 27 days after inoculation. the microscopical results, which utilized normal balb/c and thymectomized-irradiated b6c3f(1) mice, showed that the tissue responded first with an influx of polymorphonuclear cells and later lymphocytes and m ... | 1973 | 4570280 |
| [immunologic and histomorphologic features of responsiveness in patients with leprosy at different stages of treatment]. | 1972 | 4569353 | |
| evaluation of cell mediated immune responses in untreated cases of leprosy. | 1972 | 4567646 | |
| an attempt to culture mycobacterium leprae in cell-free, semisynthetic, soft agar media. | this paper describes an attempt to culture m. leprae from leprous nodules, using cell-free, semisynthetic, soft agar media, and the effects of varying the incubation temperature and the composition of the basic medium, as well as of pretreating the bacterial suspensions with alkali. the identification test carried out in leprosy patients by intradermal injection of bacillary suspensions prepared from the primary cultures and third subcultures suggested that the bacterial masses that had formed i ... | 1972 | 4566288 |
| inhibition of the multiplication of mycobacterium leprae by methimazole. | 1972 | 4565731 | |
| adjuvant activity of mycobacterium leprae. | mycobacterium leprae organisms isolated from infected spleen and liver tissue by zonal centrifugation were shown to possess adjuvant activity. histochemical examination of the footpad macrophage epithelioid granuloma showed that macrophages contained large amounts of hemosiderin after the injection of m. leprae and much smaller amounts after the injection of m. tuberculosis. | 1972 | 4565054 |
| ultrastructural changes in cells of the mouse footpad infected with mycobacterium leprae. | ultrastructural changes in cells of the mouse footpad are described which occurred during the log phase of multiplication, the plateau, and the stationary phase of growth of mycobacterium leprae.balb/c mice were inoculated in the right hind footpad with 5 x 10(3) organisms and sacrificed in pairs at 86 to 173 days after inoculation. tissue samples were prepared for electron microscopy by standard techniques. during the early growth phase of m. leprae in the mouse footpad, few organisms can be de ... | 1972 | 4564400 |
| animal models for research in leprosy. | 1972 | 4563001 | |
| recent trends in leprosy research. | 1972 | 4562677 | |
| an evaluation of transfer factor as immunotherapy for patients with lepromatous leprosy. | 1972 | 4562439 | |
| cross reactivity of mycobacterium laprae and bcg. a report on further studies. | 1972 | 4562385 | |
| preparation of purified suspensions of mycobacterium leprae and mycobacterium lepraemurium from biopsy material. | 1972 | 4562384 | |
| combinations of drugs against mycobacterium leprae studied in mice. | 1972 | 4562383 | |
| studies in the viability of mycobacterium leprae in human liver and bone marrow using thymectomized mouse foot pad technic. | 1972 | 4562382 | |
| summary of recent abstracts. 8. leprosy. | 1972 | 4562257 | |
| a test for the determination of competency in clearing bacilli in leprosy patients. | a skin test has been developed to determine the degree of competency in clearing bacilli from the tissues of patients suffering from various forms of leprosy. the test involves the intradermal injection of a suspension of killed mycobacterium leprae. the response of leprosy patients to the injection of other mycobacterial antigens, one prepared from m. lepraemurium and another from an atypical mycobacterium from a hamster, was also investigated in order to study the isopathic phenomenon. since l ... | 1972 | 4561454 |
| immunological determination of mycobacterium leprae by means of cytoplasmic antigens. | mycobacterium leprae was isolated and purified from lepromas, the spleen, and the liver of leprosy patients. an immunodiffusion analysis of the cytoplasms obtained from four lots of m. leprae and m. lepraemurium, 295 strains of different actinomycetales, and 12 other bacteria was performed with the use of the cytoplasm antisera. immunological relationships were revealed between the cytoplasms of m. leprae, m. lepraemurium, m. avium, m. gallinarum, m. tuberculosis, m. simiae, m. kansasii, m. chit ... | 1972 | 4559465 |
| histopathological study of early skin lesions in leprosy. | 1972 | 4559401 | |
| rapid bactericidal effect of rifampin on mycobacterium leprae. | 1972 | 4559066 | |
| the death rate of mycobacterium leprae during treatment of lepromatous leprosy with acedapsone (dadds). | 1972 | 4559065 | |
| mycobacterium leprae: club and other forms of unknown viability. | 1972 | 4558677 | |
| serum lipids in leprosy. | 1972 | 4557091 | |
| the continuous bacteremia of lepromatous leprosy. | 1972 | 4555967 | |
| the effect of rifampicin and dapsone on experimental mycobacterium leprae infections: minimum inhibitory concentrations and bactericidal action. | 1972 | 4555734 | |
| [chemotherapy of leprosy--effect of the anti-leprotic agent on the growth of acid-fast bacilli in cutaneous and mucous tissue]. | 1972 | 4554827 | |
| clofazimine therapy of lepromatous leprosy caused by dapsone-resistant mycobacterium leprae. | 1972 | 4554496 | |
| transfer factor. | 1972 | 4554090 | |
| incorporation of tritiated thymidine by leprosy bacilli in cultures of human lepromatous macrophages. | 1972 | 4553085 | |
| prolongation of the lag phase of mycobacterium leprae by dapsone. | 1972 | 4550215 | |
| sequential blockade of the mycobacterial de novo folate pathway. a review. | 1971 | 4399473 | |
| kinetic testing of drugs against mycobacterium leprae in mice. activity of cephaloridine, rifampin, streptovaricin, vadrine, and viomycin. | 1971 | 4398128 | |
| [an unusual diagnosis in practitioner dermatology]. | 1969 | 4389292 | |
| in vitro effects of some chemotherapeutic agents on mycobacteria. | examination of the bactericidal and bacteriostatic effects of nine antibiotics on atypical mycobacteria revealed that streptovaricin complex and streptovaricin c exerted bactericidal effects on several strains in concentrations lower than 1.0 mug/ml. an exposure to the drug for 48 hr at 37 c was necessary to effect a complete inactivation of more than 99.9% of the exposed microorganisms. the appearance of strepto-varicin-resistant mutants was observed. however, these mutants were unstable, and r ... | 1967 | 4383871 |
| peripheral nerve involvement in leprosy: quantitative histologic aspects. | 1974 | 4374004 | |
| the pathogenesis of the neuropathy in dimorphous leprosy: electron microscopic and cytochemical studies. | 1974 | 4366311 | |
| immunological problems in leprosy research. 1. | this memorandum reviews the present status of knowledge of the immunology of leprosy, with particular attention to developments since the publication of a similar review in 1970. the different types of lepromin reaction and their significance in healthy contacts and in patients with tuberculoid and lepromatous leprosy are discussed. the immunological responsiveness of patients with leprosy is also considered, with special attention to in vitro methods for evaluating this response. part 2 of the ... | 1973 | 4355402 |
| implications of chemoautotrophism in mycobacterium leprae. | 1973 | 4349602 | |
| recognition of leprosy. | 1973 | 4348376 | |
| [leprosy research]. | 1971 | 4327066 | |
| antibodies to mannophosphoinositides in leprosy patients. | 1970 | 4324604 | |
| summary of recent abstracts. 8. leprosy. | 1970 | 4321145 | |
| mycobacterium leprae in nerve lesions in lepromatous leprosy. an electron microscopic study. | 1970 | 4313451 | |
| effects of antilymphocytic serum on host responses to infectious agents. | 1970 | 4312737 | |
| unexpected high incidence of tumours in thymectomized mice treated with anti-lymphocytic globulin and mycobacterium leprae. | 1969 | 4304484 | |
| acute necrotizing lepromatous lymphadenitis: an erythema-nodosum-leprosum-like reaction in lymph nodes. | histological examination of lymph-node biopsy specimens in 12 patients with erythema nodosum leprosum showed almost complete replacement of the node by lepromatous granuloma, together with considerable polymorph infiltration. ziehl-neelsen staining demonstrated numerous mycobacterium leprae present in the nodes. the majority of these patients were very ill, and responded to prednisolone or corticotrophin.it is suggested that the histological appearances may represent an intensive inflammatory re ... | 1968 | 4300767 |
| cytological studies on host-parasite relations in experimental leprosy of mice. | 1968 | 4297645 | |
| metabolism of mycobacterium leprae separated from human leprosy nodules. | 1967 | 4290018 | |
| transmission of mycobacterium leprae to animals. nerve involvement in the ears of hamsters. | 1965 | 4285970 | |
| acid mucopolysaccharide metabolism in leprosy. 2. subcellular localization of hyaluronic acid and beta-glucuronidase in leprous infiltrates suggestive of a host-mycobacterium leprae metabolic relationship. | electron- and light microscopic analyses were conducted on leprosy skin biopsies relative to the origin of hyaluronic acid, which has previously been observed to be distributed inversely in ratio to the degree of cell- mediated immunity. the present study investigated the subcellular localization of hyaluronic acid and its degrading enzyme in various types of leprosy. hyaluronic acid in some lepromatous leprosy cases was shown to be accumulated in the limiting membranes of the phagosomes of lepr ... | 1974 | 4282081 |
| effect of inorganic and organic substances containing sulfur or nitrogen and of vitamins on the growth of mycobacterium leprae. | 1974 | 4278072 | |
| mycobacterium leprae in a muscle spindle. | 1972 | 4262739 | |
| [treatment of lepromatous leprosy by ethionamide]. | 1972 | 4261347 | |
| experimental arthus reactions using the same antigen in soluble and corpuscular form. | 1971 | 4255853 | |
| [induction with bacilli extracted from murine lepromas, of lymphoblastic transformation of lymphocytes from human lepers]. | 1970 | 4252357 |