Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| a nonsteroid anti-inflammatory drug exacerbates coxsackie b3 murine myocarditis. | nonsteroid anti-inflammatory drugs are often used to treat myalgias and arthralgias in enteroviral infections, but their effects on acute viral myocarditis are unknown. the effect of the nonsteroidal anti-inflammatory drug, ibuprofen, on acute viral myocarditis was studied in 75 four week old male balb/c mice infected with 1.75 x 10(7) plaque-forming units of coxsackie virus b3 on day 0. ibuprofen was given intraperitoneally at a dose of 15 mg/kg body weight daily. the mice were assigned to four ... | 1985 | 2995470 |
| opiate- and alpha 2-adrenoceptor-induced hyperpolarizations of locus ceruleus neurons in brain slices: reversal by cyclic adenosine 3':5'-monophosphate analogues. | the purpose of this study was to investigate the ionic and second messenger mechanisms underlying the hyperpolarizations induced by the selective alpha 2-adrenoceptor agonist clonidine and the opiate agonist morphine in the locus ceruleus. intracellular recordings were carried out in rat brain slices, and drugs at known concentrations were administered in the perfusate. the cyclic adenosine 3':5'-monophosphate (camp) analogues 8-bromo-camp and dibutyryl camp, while not altering basal activity, r ... | 1985 | 2993542 |
| macrophage colony-stimulating factor (m-csf) enhances the capacity of murine macrophages to secrete oxygen reduction products. | the capacity of macrophage colony-stimulating factor (m-csf) to enhance respiratory burst activity in peritoneal macrophages was measured. macrophages incubated for 48 hr or more with concentrated l cell-conditioned medium as a source of m-csf released two to three times as much o2- in response to pma as did unexposed macrophages. stimulation was noted at concentrations of colony-stimulating activity from 0.1 to 2000 u/ml and was maximal at 10 to 100 u/ml. purified, endotoxin-free csf enhanced s ... | 2010 | 2991376 |
| receptors for epidermal growth factor in the rat uterus. | uterine membranes contain high affinity [dissociation constant (kd) = 0.36 nm], saturable binding sites for [125i]iodo-epidermal growth factor (egf). the binding of [125i] iodo-egf is specific since it is abolished by excess unlabeled egf but not by excess unlabeled insulin, fibroblast growth factor, or multiplication-stimulating activity. incubation of [125i] iodo-egf with uterine membranes, followed by chemical cross-linking with disuccinimidyl suberate and detergent extraction reveals a major ... | 1985 | 2988913 |
| conditioned taste aversion suppresses induction of delayed-type hypersensitivity immune reactions. | conditioned taste aversion was induced in mice by pairing saccharin drinking with an intraperitoneal injection of lithium chloride, a toxic but nonimmunosuppressive drug. conditioned mice showed not only suppressed saccharin drinking but also a 75% reduction in the induction of delayed-type hypersensitivity immune responses to low doses of sheep erythrocytes. this effect was observed with doses of lithium chloride which had no effect of their own on immune functions. in addition, a reduction in ... | 1985 | 2987987 |
| respiratory syncytial virus fusion glycoprotein: nucleotide sequence of mrna, identification of cleavage activation site and amino acid sequence of n-terminus of f1 subunit. | the amino acid sequence of respiratory syncytial virus fusion protein (fo) was deduced from the sequence of a partial cdna clone of mrna and from the 5' mrna sequence obtained by primer extension and dideoxysequencing. the encoded protein of 574 amino acids is extremely hydrophobic and has a molecular weight of 63371 daltons. the site of proteolytic cleavage within this protein was accurately mapped by determining a partial amino acid sequence of the n-terminus of the larger subunit (f1) purifie ... | 1985 | 2987829 |
| respiration-driven na+ pump and na+ circulation in vibrio parahaemolyticus. | sodium circulation in vibrio parahaemolyticus was investigated. we observed respiration-driven na+ extrusion from cells by using a na+ electrode. the na+ extrusion was insensitive to a proton conductor, carbonyl cyanide m-chlorophenylhydrazone, and sensitive to a respiratory inhibitor, cn-. these results support the idea of the existence of a respiratory na+ pump in v. parahaemolyticus. the respiration-driven na+ extrusion was observed only under alkaline conditions. | 1985 | 2985548 |
| measuring gene expression with light. | light is produced by recombinant escherichia coli that contain lux genes cloned from the marine bacterium vibrio fischeri. the bioluminescence phenotype requires genes for regulatory and biochemical functions, the latter encoded by five lux genes contained in a single operon. these lux genes were disconnected from their native promoter and inserted into the transposon mini-mu. the resulting transposon, mini-mulux, could induce mutations by insertional inactivation of a target gene, and the lux d ... | 1985 | 2983423 |
| the relationships between oligomeric structure and function of band 3 protein from human erythrocyte membranes: present knowledge and suggestions for further experiments. | 1988 | 2976450 | |
| [treatment of chronic cardiac decompensation in patients 70 years of age and older]. | 2010 | 2976342 | |
| [mechanisms of cutaneous accidents related to non-steroidal anti-inflammatory agents]. | 2010 | 2976215 | |
| activation of a cytosolic serine protein kinase by epidermal growth factor. | exposure of a-431 cells to epidermal growth factor (egf) results in a rapid enhancement (approximately 10-fold) of cytosolic serine protein kinase activity. the increase in serine kinase activity may be detected using a number of peptide and protein substrates. enhancement of kinase activity occurs within 1 min of exposure of the cells to egf and reaches a maximum in 5 min. similar results were obtained with a variety of cell lines. we have partially purified the egf-activated kinase from a-431 ... | 2010 | 2974035 |
| lowering effect of pantethine on plasma beta-thromboglobulin and lipids in diabetes mellitus. | pantethine in a dosage of 600 mg for the first 3 months, and in a dosage of 1200 mg for the second 6 months was given to 16 diabetics in whom plasma beta-thromboglobulin was raised (greater than 50 ng/ml). plasma beta-tg levels decreased significantly with pantethine treatment for 9 months. plasma triglyceride, total cholesterol, apo e and apo cii levels decreased significantly after 9 months. plasma ldl-c and atherogenic index (ldl-c/hdl-c ratio or apo b/apo ai ratio) tended to decrease with tr ... | 2010 | 2963604 |
| regulatory role of fcr+ and fcr- monocyte subsets in mycobacterium leprae-induced lymphoproliferative response in vitro. | we investigated nine rhesus monkeys (macaca mulatta) inoculated with mycobacterium leprae and three normal human contacts. peripheral blood monocytes were separated into fc receptor positive (fcr+) and fc receptor negative (fcr-) fractions, and their regulatory role in the lymphoproliferative response in vitro to m. leprae was studied. fcr- monocytes had strong antigen presentation activity and produced no suppressor effect while fcr+ monocytes had weak antigen presentation activity and produced ... | 1987 | 2957129 |
| regulatory role of fcr+ and fcr- monocyte subsets in mycobacterium leprae-induced lymphoproliferative response in vitro. | we investigated nine rhesus monkeys (macaca mulatta) inoculated with mycobacterium leprae and three normal human contacts. peripheral blood monocytes were separated into fc receptor positive (fcr+) and fc receptor negative (fcr-) fractions, and their regulatory role in the lymphoproliferative response in vitro to m. leprae was studied. fcr- monocytes had strong antigen presentation activity and produced no suppressor effect while fcr+ monocytes had weak antigen presentation activity and produced ... | 1987 | 2957129 |
| the balans chair and its semi-kneeling position: an ergonomic comparison with the conventional sitting position. | recently, the balans chair has been introduced with claims that, because of its semi-kneeling position, individuals will experience decreased low-back pain (lbp) as well as improvement in circulation. this study investigated the validity of these claims. twenty healthy subjects were randomly assigned to one of two groups. group 1 subjects sat in the balans chair for a 30-minute study period and then sat in a conventional office chair for an additional 30-minute period. group 2 subjects were stud ... | 1987 | 2954222 |
| [value of abdominal pulsed duplex sonography]. | pulsed duplex sonography is a routine method for evaluation of superficial vessels. especially in the assessment of the extracranial vessels of the head and neck region duplex sonography proved to be the method of choice. modern technology allows the investigation of deep vessels by pulsed doppler sonography. this study tries to define the value of the combination of real time sonography and pulsed deep doppler sonography in the abdomen on the basis of the author's experiences. value and limitat ... | 2010 | 2954181 |
| interactions of monomeric igg bearing covalently bound c3b with polymorphonuclear leucocytes. | the interactions of monomeric igg, monomeric c3b, dimeric c3b, and c3b covalently bound to igg (c3b-igg) with neutrophils were examined. c3b-igg heterodimers exhibited an increased affinity of binding to neutrophils, relative to c3b, both at half normal ionic strength (five-fold enhancement) and at normal ionic strength (six-fold enhancement). binding of monomeric igg to neutrophils was barely detectable and did not permit direct measurements of affinity in our assay conditions. the increased af ... | 2010 | 2953672 |
| possible role of helper and cytolytic t cells in mycobacterial infections. | 1986 | 2952852 | |
| [results of examining the population in a region with high morbidity for oral mucosal cancer: precancerous changes]. | interviewing and examination of a population characterized by a high level of morbidity of oral cavity cancer, supposedly induced by the use of nas, established a high incidence of leukoplakia and preleukoplakia at this site which are identified as precancerous lesions. the highest relative risk of oral cavity leukoplakia was found in persons who both chew nas and smoke tobacco (12.4). relative risk of leukoplakia is also elevated in those who either chew nas (5.6) or smoke cigarettes (7.7). thi ... | 1987 | 2950660 |
| [tuberous iododerma due to solutan]. | 2010 | 2949449 | |
| regulation of autoimmune disease physiological and therapeutic. | an important question is how the immune system can control the behavior of autoimmune effector lymphocytes. my colleagues and i have investigated this question in four models. three models of organ specific autoimmune diseases were studied using the specific autoimmune lines or clones of t lymphocytes functionally involved in the disease process. the fourth model was an anti-idiotypic network triggered spontaneously by autoantibodies. this article reviews the evidence indicating that healthy ind ... | 2010 | 2948901 |
| ultrastructural changes in the sarcoplasmic reticulum in acute myocardial ischemia. | we investigated the morphologic changes in the sarcoplasmic reticulum (sr) in acute myocardial ischemia, induced by occlusion of the coronary artery in the canine heart, by freeze-fracture of sr in situ and in vitro, and they were compared to the alterations in ca++-stimulated atpase activity and protein composition of the isolated sr. both sr in situ and the isolated sr exhibited typical intramembranous particles with diameters of 70 to 90 a in freeze-fracture replicas. the intramembranous part ... | 1986 | 2948034 |
| the comparative in vitro activity of twelve 4-quinolone antimicrobials against enteric pathogens. | the minimal inhibitory concentrations (mics) of twelve 4-quinolone antimicrobials were determined for salmonella typhi (25), salmonella spp. (50), shigella spp. (50), campylobacter jejuni (100), vibrio cholerae (10), vibrio parahaemolyticus (10), yersinia enterocolitica (25), aeromonas hydrophila (25) and plesiomonas shigelloides (10). mics were determined using an agar dilution technique in mueller-hinton agar (oxoid, england) supplemented with 10% lysed horse blood. antibiotic containing plate ... | 1985 | 2941257 |
| [fertilization results in superovulated ewes and goats after transmural-intrauterine insemination controlled by laparoscopy]. | a comparative experiment in oestrous synchronized and superovulated ewes and does is described on which fertilization was studied following natural mating or transmural intrauterine insemination by laparoscopy. thirty-two ewes were inseminated into each uterine horn with 50-100 microliter of fresh undiluted semen, whereas 26 ewes were mated by fertile rams. fertilization rates of eggs recovered 5-7 days later were 93.7% (163/174) and 60.5% (78/129) respectively. eight does were inseminated by la ... | 1986 | 2940732 |
| combined thrombolytic therapy and coronary angioplasty for acute myocardial infarction. | from september, 1983, to august, 1984, combined thrombolytic therapy and percutaneous transluminal coronary angioplasty was used to treat 22 cases of acute myocardial infarction. initial coronary angiograms showed total obstruction in 13 and severe stenosis in 9. intracoronary infusion of urokinase reopened 7 of 13 totally occluded lesions but left a residual severe stenosis. coronary angioplasty opened all of the remaining totally obstructed lesions and decreased the stenosis in 14 of 16 stenos ... | 2010 | 2939702 |
| [diseases of the gastrointestinal tract and the development of stomach cancer]. | an analysis of 1,108 histories of outpatients with a follow-up of 10 years and longer (up to 40 years) was carried out in orekhovo-zuyevo (population--132,301). 554 patients had stomach cancer diagnosed in 1973-1978 while the other 554 selected at random were in control. the results are discussed in detail. | 2010 | 2938332 |
| [temporary minimal esophagostomy in the surgical treatment of malignant esophago-respiratory fistulas]. | oesophago-bronchial and oesophago-pleural fistulae are serious complications of oesophageal cancers. they occur earlier than is generally believed and, if untreated, result in death caused by septic and respiratory complications. an original two-stage surgical method is reported and illustrated by 3 cases. the first stage consists of excluding the oesophagus at both ends and introducing, through a small oesophagostomy, a foley's catheter to aspirate the secretions; the cardia is excluded by stap ... | 2010 | 2938171 |
| i.v. sedation for conservative dentistry. a comparison of midazolam and diazepam. | midazolam and the emulsion formulation of diazepam were compared in a cross-over study in 50 patients undergoing out-patient conservative dentistry, with particular regard to sedation and the quality of recovery. both agents proved effective, but sedation was achieved more rapidly with midazolam (p = 0.001) and was more effective (p less than 0.02). significantly greater anterograde amnesia for the dental procedure (p less than 0.001) and a more rapid return to normal activities (p less than 0.0 ... | 2010 | 2937434 |
| differential depression of hypoglossal nerve activity by alcohol. protection by pretreatment with medroxyprogesterone acetate. | upper airway obstruction during sleep occurs more commonly in men than in women and has been treated with progestational agents with some success. alcohol ingestion exacerbates sleep apnea, and recent studies have established that alcohol depresses the respiratory motor activity to upper airway muscles more than that to the diaphragm, a response pattern that favors upper airway obstruction during inspiration. to investigate the possibility that progesterone provides some protection from this act ... | 1986 | 2935056 |
| relationship between anxiety and depression. | 2010 | 2929781 | |
| britain launches genome program. | 1989 | 2928800 | |
| health care entrepreneur's key to success: break the mold. | 2009 | 2921025 | |
| three years' experience with an ileal low pressure bladder substitute. | at the beginning of this century it was realised that peristalsis would cause incontinence if bowel was used for augmentation or substitution of the bladder. trans-section of the antimesenteric border and cross-folding of the intestinal segments (goodwin's cup-patch technique) is an efficient means of solving this problem and has been successfully used in the kock pouch. we anastomosed the ileal low pressure reservoir to the membranous urethra in 22 male patients following radical cystoprostatec ... | 2010 | 2920259 |
| linkage disequilibrium, cystic fibrosis, and genetic counseling. | strong linkage disequilibrium occurs between the cystic fibrosis (cf) locus and polymorphisms detected with the dna probes xv-2c and km-19. in a north american population, 86% of cf chromosomes occur with a haplotype which occurs on only 14% of normal chromosomes. an individual homozygous for the highest-risk haplotype has an 81-fold greater probability of carrying a cf allele than does an individual homozygous for the lowest-risk haplotype. the linkage-disequilibrium data can be used for prenat ... | 2010 | 2916578 |
| comparison of airway pathologic lesions after high-frequency jet or conventional ventilation. | high-frequency jet ventilation in neonates has been associated with airway damage ranging from focal necrosis to complete airway obstruction with mucus and severe necrotizing tracheobronchitis. however, studies have lacked consistent criteria for assessment, and jet ventilation systems have varied widely. we compared autopsy and histopathologic findings in six neonates who died after prolonged jet ventilatory support with findings in six matched controls who died after receiving conventional ven ... | 2010 | 2916497 |
| dice: nonclinical causes of overtreatment. | 2010 | 2916481 | |
| fine needle aspiration cytology of recurrent ectopic meningioma. | fine needle aspiration was performed on a recurrent extracranial meningioma in the left pterygomaxillary and temporal fossas in a 39-year-old woman. cytologic and electron microscopic study of the aspirate and comparison to the previously resected specimen proved the recurrent nature of the lesion. the cytologic and ultrastructural findings in meningiomas are discussed with special consideration of the differential diagnosis in extracranial sites. | 2010 | 2916374 |
| retroperitoneal ganglioneuroblastoma. report of a case diagnosed by fine needle aspiration cytology and electron microscopy. | fine needle aspiration performed on a large retroperitoneal mass in a 12-year-old boy showed neuroblasts in different stages of maturation intermingled with ganglion cells, leading to a cytologic diagnosis of ganglioneuroblastoma. this diagnosis was supported by electron microscopic study of the aspirate, which showed features of neuroblastic differentiation, and by histologic study of the resected tumor. | 2010 | 2916373 |
| saturable binding sites mediate the entry of african swine fever virus into vero cells. | binding experiments of 3h-labeled african swine fever virus to susceptible vero cells have shown the presence of saturable binding sites for african swine fever virus on the plasma membrane. the scatchard analysis of the binding data at equilibrium indicates the existence of about 10(4) cellular receptor sites per cell with a dissociation constant (kd) of 70 pm. virus entry into vero cells is mediated by a saturable component, since tritiated african swine fever virus saturable binding and uptak ... | 1989 | 2916331 |
| iron regulation of swarmer cell differentiation of vibrio parahaemolyticus. | vibrio parahaemolyticus has two distinct cell types, the swimmer cell and the swarmer cell, adapted for locomotion in different circumstances. the swimmer cell, produced when the bacterium is grown in liquid media, is a short rod with a single sheathed polar flagellum. the swarmer cell, produced when v. parahaemolyticus is grown on solidified media, is greatly elongated and synthesizes, in addition to the polar flagellum, numerous unsheathed lateral flagella which are responsible for translocati ... | 1989 | 2914871 |
| improved sexual function in hemodialysis patients on recombinant erythropoietin: a possible role for prolactin. | as it was reported that correction of anemia in long-term hemodialysis patients by recombinant human erythropoietin (r-huepo) is associated with improved sexual function, we conducted the present study to further delineate the mechanism(s) by which this is brought about. serum prolactin, testosterone, and parathyroid hormone (pth) levels were followed during 4 months of r-huepo therapy. within 4 months of treatment with r-huepo, hematocrit values rose from 23.7 +/- 1.2 to 35.7 +/- 0.2% and hemog ... | 1989 | 2914405 |
| renal metabolism of the oxidized form of ascorbic acid (dehydro-l-ascorbic acid). | we evaluated whether specific transport and metabolic properties exist in rat and guinea pig kidney for handling the immediate oxidative product of ascorbic acid, dehydro-l-ascorbic acid. isolated tubules were used to measure uptake of 10 microm [14c]-dehydro-l-ascorbic acid over an 8-min incubation period. uptake did not show dependence on the bathing media electrolyte composition but was inhibited to some extent by glucose. in tubules of both animal species the majority of 14c label present in ... | 1989 | 2912166 |
| an experimental study of susceptibility to infection after hemorrhagic shock. | hemorrhagic shock has been associated with an increased risk of infection after injury. the immediate and long term effects of hemorrhagic shock without tissue injury on the susceptibility of an animal to infection and the efficacy of antibiotic prophylaxis to prevent infection in this setting were examined. sprague-dawley rats were subjected to hemorrhagic shock (ld15) by bleeding to a mean arterial pressure of 45 millimeters of mercury for 45 minutes and were resuscitated with shed blood and n ... | 1989 | 2911791 |
| fine-needle aspiration of inguinal lymph nodes in gynecologic practice. | palpable inguinal lymph nodes are a common finding in gynecologic patients. assessment of such nodes is especially important in the clinical staging of pelvic cancers. to determine the accuracy, safety, and usefulness of fine-needle aspiration in this setting, we retrospectively reviewed pathologic and clinical data from 62 consecutive aspirates of inguinal lymph nodes in 48 gynecologic patients, of whom 42 had cancer. aspirates from 37 patients yielded diagnostic material. aspirated tumor cells ... | 2010 | 2911432 |
| [purification and characterization of vibrio parahaemolyticus pili isolated from a patient with diarrhea: comparative studies with vibrio cholerae o1 pili]. | 1988 | 2907917 | |
| [an operative case of multiple endocrine neoplasia type 1 (men type 1) with insulinoma]. | 2009 | 2906375 | |
| biological markers of suicide risk and adolescent suicide. | 2010 | 2905935 | |
| production of pili on vibrio parahaemolyticus. | electron microscopic examination showed that all strains of vibrio parahaemolyticus examined had pili on their surface when the organism was grown on marine agar at 28 degrees c for 6-12 h. the pili were morphologically stable on heat treatment at 60 degrees c for 10 min, but both the lateral and polar flagella possessed by this organism were labile. no immunological cross-reactivity between pili of enterotoxigenic escherichia coli and vibrio cholerae non-01 and those of v. parahaemolyticus was ... | 1988 | 2905206 |
| effect of oversulphated chondroitin and dermatan sulphate upon thrombin and factor xa inactivation by antithrombin iii or heparin cofactor ii. | the kinetics of inhibition of human thrombin and factor xa by antithrombin iii or heparin cofactor ii were examined under pseudo-first-order conditions as a function of the concentration of naturally occurring oversulphated chondroitin and dermatan sulphates. the sulphated glycosaminoglycans (gags) studied were chondroitin sulphate d (csd) (glca-2-so4-galnac-6-so4), chondroitin sulphate k (csk) (glca-3-so4-galnac-4-so4), chondroitin sulphate h (csh) (ida-galnac-4,6-diso4) and polysulphated derma ... | 1988 | 2902851 |
| evidence of functional alpha 2-adrenergic receptors in adult-rat adipocytes by using the agonist uk 14304. | the aim of this study was to re-assess whether alpha 2-adrenergic receptors were present in rat adipocytes, by using uk 14304, a new and very selective alpha 2-agonist. the following observations demonstrate the presence of functional alpha 2-adrenoceptors in rat adipocytes. (1) adipocyte lipolysis was dose-dependently inhibited by uk 14304 (maximal effect 80% at 1 microm-uk 14304, 45% at 10 microm-uk 14304, under basal or theophylline-stimulated conditions respectively). (2) uk 14304 bound spec ... | 1988 | 2901830 |
| dissociation-reconstitution experiments with nbd-modified f1: support for the presence of two catalytic beta-subunits. | 2010 | 2901754 | |
| responses of hippocampal pyramidal cells to putative serotonin 5-ht1a and 5-ht1b agonists: a comparative study with dorsal raphe neurons. | in low cerveau isolé transected rats, the effects of microiontophoretic application of putative serotonin 5-ht1a and 5-ht1b agonists on the spontaneous firing rate of ca1 pyramidal cells were compared to those of 5-ht. in contrast to the large current-dependent suppression of unit activity observed with 5-ht, the 5-ht1a compounds, ipsapirone, 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)-tetralin) and ly 165163 (p-aminophenylethyl-m-trifluoromethylphenylpiperazine) and the 5-ht1b compounds, mcpp (m- ... | 1988 | 2901680 |
| importance of pulmonary blood volume and aortic blood pressure in regulation of left ventricular function. | 1988 | 2900297 | |
| gastric secretion and gastrin under progressive doses of somatostatin-14 and -28 administered intraperitoneally to the rat. | the actions of progressive doses of intraperitoneally (ip) administered somatostatin-14 (ss-14) and -28 (ss-28) on gastric secretion (acid, pepsin) and mucosal blood flow (mbf) were studied in conscious gastric fistula rats both under basal conditions and under additional administration of pentagastrin. also, somatostatin-like immunoreactivity was measured in aortal blood in all groups as well as aortal gastrin levels under basal conditions. ip infusion of equimolar doses of ss-14 and ss-28 resu ... | 1988 | 2897678 |
| the tissue distribution of the 3 alpha-fucosyl-n-acetyl lactosamine determinant recognized by the cd15 monoclonal antibodies cmrf-7 and 27. | two monoclonal antibodies, cmrf-7 and 27, which react with cells of the granulocytic series, were obtained from hybridomas cloned from separate fusions. biochemical studies indicate that both antibodies are of the cd15 group and react with the antigenic determinant 3 alpha-fucosyl-n-acetyl lactosamine (hapten x) expressed on some glycolipids and several different granulocyte glycoproteins with a wide range of molecular weights. the antigen was found on some promyelocytes and more differentiated ... | 1988 | 2897656 |
| effect of human growth hormone-releasing factor (1-29)nh2 on growth hormone release and milk production in dairy cows. | twelve cows (209 d in lactation, 642 kg bw) were used in an experiment conducted over four 10-d periods (one preinjection, one injection, and two postinjection). gelatine (n = 6) or 10 mg of growth hormone-releasing factor in gelatine (n = 6) was injected subcutaneously at 1000 h every day on d 11 to 20. data were averaged for the last 5 d of each period. during the injection period, milk, fat, and protein yields increased by 3 kg.d-1 (14.3%), .14 kg.d-1 (16.7%), and .12 kg.d-1 (15.4%), respecti ... | 1988 | 2897385 |
| fibronectin is a component of the sodium dodecyl sulfate-insoluble transglutaminase substrate. | liver plasma membranes contain a morphologically distinct protein complex which serves as a substrate for the plasma membrane-associated transglutaminase. the complex, which appears as a two-dimensional sheet, is insoluble in sodium dodecyl sulfate and reducing agents and has been named sits for sodium dodecyl sulfate-insoluble transglutaminase substrate (tyrrell, d. j., sale, w. s., and slife, c. w. (1988) j. biol. chem. 263, 1946-1951). polyclonal antibodies raised against sits were used to pr ... | 1988 | 2897368 |
| human t-cell leukemia/lymphoma viruses: atl and aids. | 1985 | 2897327 | |
| isolated duodenal tamponade for treatment of bleeding duodenal ulcer. | 2010 | 2895833 | |
| tardive dyskinesia. | 2010 | 2892565 | |
| structural and functional modifications of peripheral large arteries in hypertensive patients. | 1987 | 2889808 | |
| mechanism of action of somatostatin in the hippocampal slice. | 1987 | 2888131 | |
| a dot immunobinding assay (dia) on nitrocellulose membrane for the serological detection of antibodies to entamoeba histolytica. | a rapid, cheap, simple and specific serological test of adequate sensitivity for detecting igg antibodies against entamoeba histolytica antigen is described. axenically cultured amoebic antigen was used to precoat the nitrocellulose membrane. the strips were incubated with test samples and later with horseradish peroxidase (hrpo) labelled protein-a conjugate. a dark blue spot was obtained by treatment with peroxidase substrate, 4-chloro-1-naphthol, in positive samples. serum samples from 32 heal ... | 1986 | 2885949 |
| 1,4-dithiothreitol-induced changes in histamine h1-agonist efficacy and affinity in the longitudinal smooth muscle of guinea-pig ileum. | the effect of 1,4-dithiothreitol (dtt) on histamine h1-receptor agonist affinity and efficacy has been investigated in longitudinal muscle strips of guinea-pig ileum. exposure of ileal smooth muscle to dtt significantly increased the maximal responses to the partial agonists skf71473 and de-2pea, indicative of an increase in agonist efficacy. this effect was paralleled by a small decrease in ec50 values. in contrast, dtt produced a parallel displacement of the concentration-response curve to the ... | 1987 | 2880626 |
| gastroenteritis due to kanagawa negative vibrio parahaemolyticus. | 1987 | 2880146 | |
| reduction of pituitary size by the somatostatin analogue sms 201-995 in a patient with an islet cell tumour secreting growth hormone releasing factor. | acromegaly is rarely caused by the ectopic secretion of growth hormone releasing factor (grf) from peripheral neuroendocrine tumours. we evaluated the ability of a recently developed somatostatin analogue (sms 201-995, sandoz) to reduce hormone levels and pituitary size in a young woman with acromegaly and zollinger-ellison syndrome secondary to a metastatic pancreatic islet cell tumour secreting grf and gastrin. gastrin, grf, and growth hormone (gh) levels declined dramatically following the in ... | 2010 | 2876570 |
| [regulation of gamma-glutamyltransferase activity and synthesis in animal tissues]. | 2010 | 2876560 | |
| [arterial hypertension in the aged]. | 2010 | 2876472 | |
| therapeutic approach to the vasculitic syndromes. | 2010 | 2876378 | |
| report of a wound infection caused by vibrio parahaemolyticus and vibrio vulnificus. | the present case describes a foot wound caused by a clam shell from which both vibrio parahaemolyticus and vibrio vulnificus were recovered. although extraintestinal infections associated with vibrio parahaemolyticus have been reported previously, the simultaneous isolation of two marine vibrios from our case suggests that these organisms may coexist in mixed infections from a common source. | 1986 | 2875824 |
| [enteropathogens in travellers returning from the tropics]. | diarrhea is not only the most common health hazard during travel in the tropics but also the most frequent condition which prompts returning travellers to see a physician. the prevalence of bacterial and parasitic enteropathogens in people attending our outpatient department after returning from the tropics has been studied and the laboratory results of stool examinations have been compared with clinical symptoms. of the 173 persons enrolled, 19 (11%) harboured bacterial pathogens and pathogenic ... | 1986 | 2875520 |
| potent antagonism of escherichia coli, bacteroides ovatus, fusobacterium varium, and enterococcus faecalis, alone or in combination, for enteropathogens in anaerobic continuous flow cultures. | interactions between representative strains of four predominant resident bacteria of the human colon, escherichia coli, enterococcus faecalis, bacteroides ovatus, and fusobacterium varium, and strains of seven enteropathogens, yersinia enterocolitica, shigella flexneri, salmonella typhimurium, vibrio parahaemolyticus, v. cholerae serogroup non o1, staphylococcus aureus, and clostridium perfringens, were examined in studies with an anaerobic continuous flow culture system and medium resembling th ... | 1986 | 2875188 |
| [simplified technic for laparoscopy in cases of cryptorchism]. | 2010 | 2873655 | |
| circadian rhythms: benzodiazepines set the clock. | 2010 | 2871494 | |
| bronchodilator effects of terbutaline and theophylline alone and in combination in patients with chronic obstructive lung disease. | thirteen patients with severe partially reversible chronic obstructive lung disease received long-term treatment with a sustained-release preparation of theophylline and a beta 2-agonist (terbutaline) alone and in combination. combination therapy induced significantly greater bronchodilation than treatment with terbutaline alone in the recommended dose. in 9 out of 13 patients the peak flows were higher during combination therapy than during theophylline treatment alone, but this did not reach s ... | 2006 | 2870630 |
| bronchodilator effects of terbutaline and theophylline alone and in combination in patients with chronic obstructive lung disease. | thirteen patients with severe partially reversible chronic obstructive lung disease received long-term treatment with a sustained-release preparation of theophylline and a beta 2-agonist (terbutaline) alone and in combination. combination therapy induced significantly greater bronchodilation than treatment with terbutaline alone in the recommended dose. in 9 out of 13 patients the peak flows were higher during combination therapy than during theophylline treatment alone, but this did not reach s ... | 2006 | 2870630 |
| serotonergic regulation of the brain and gut beta-endorphin and dynorphin content in the rat. | a specific radioimmunoassay was used to measure immunoreactive dynorphin (ir-dyn) and beta-endorphin (ir-be) in the brain, pituitary and gut, following a pharmacological manipulation of the serotonin system. administration of the serotonin receptor agonist m-chlorophenylpiperazine (m-cpp, 2.5-5 mg/kg ip) or the serotonin releasing agent fenfluramine (20-40 mg/kg ip) induced a significant increase in the hypothalamic ir-be content and a decrease in its anterior pituitary level. these effects were ... | 1985 | 2870487 |
| accessory adrenal: an incidental finding during orchiopexy. | 2006 | 2870456 | |
| accessory adrenal: an incidental finding during orchiopexy. | 2006 | 2870456 | |
| the source of malonyl-coa in rat heart. the calcium paradox releases acetyl-coa carboxylase and not propionyl-coa carboxylase. | the formation of malonyl-coa in rat heart is catalyzed by cytosolic acetyl-coa carboxylase. the existence of this enzyme in heart is difficult to prove by the abundant occurrence of mitochondrial propionyl-coa carboxylase, which is also able to catalyze the carboxylation of acetyl-coa. we used the calcium paradox as a tool to separate cytosolic components from the remaining heart, and found that acetyl-coa carboxylase activity was preferentially released, like lactate dehydrogenase and carnitine ... | 1986 | 2869975 |
| [therapy with beta adrenergic agents]. | 2000 | 2869565 | |
| somatostatin-like immunoreactivity (sli) in pancreatic and intestinal tissues of the duck. a possible origin for the portal circulating sli. | substances with somatostatin-like immunoreactivity (sli) were extracted using 2 n acetic acid, from the three pancreatic lobes and the intestine of the duck. the concentration of sli was found to be very high in the pancreas (4.2 micrograms/g wet weight), the splenic lobe containing 80% of pancreatic sli compared with 10% for the dorsal and 10% for the ventral lobes. sli was equally distributed between duodenum, jejunum and ileum and between their mucosal and muscular layers. chromatography of p ... | 1985 | 2867025 |
| antihypertensive therapy: newer concepts and agents. | major advances have taken place in recent years with respect to our understanding of hypertensive diseases, the mechanisms of action of other therapeutic agents, and the introduction of new classes of drugs. standard therapy today uses the basic of employing nonpharmacological modalities. thereafter a stepped-care program with pharmacological entities has been advocated using diuretic, antiadrenergic, and vasodilating agents. however, new modes of action have been introduced therapeutically duri ... | 2009 | 2866842 |
| antihypertensive therapy with once-daily administration of terazosin, a new alpha 1-adrenergic-receptor blocker. | the antihypertensive activity of terazosin, an investigational alpha 1-adrenergic-receptor blocker, and its effect on blood lipids were compared with placebo in a double-blind study. after a 3-week placebo baseline period, patients were randomized to receive terazosin (n = 22) or placebo (n = 16). the dose of terazosin was titrated over 2 weeks to a maintenance dosage of 10 mg once daily for 4 weeks. antihypertensive efficacy was assessed: (1) at the end of the 24-hour dosing interval by compari ... | 2010 | 2866492 |
| branhamella catarrhalis cellulitis around a cerebrospinal fluid shunt: case report. | a cellulitis surrounding a cerebrospinal fluid shunt caused by branhamella catarrhalis is described. this is the first reported case of a cellulitis caused by this bacterium. | 1985 | 2865299 |
| post-translational processing of anglerfish islet somatostatin precursors. | two distinct somatostatin precursors are synthesized in anglerfish (af) islets. in addition to a precursor which has somatostatin 14 (ss-14) as a c-terminal cleavage product, a precursor which contains at its c-terminus [tyr7, gly10] ss-14 as a potential cleavage product is also synthesized. however, even though an arg-lys pair is located immediately n-terminal to ala1 of the c-terminal tetradecapeptide, [tyr7, gly10]ss-14 was not found in significant amounts in extracts of af islets. instead, a ... | 2010 | 2863927 |
| isotretinoin and reduction deformities. | 1985 | 2863524 | |
| possible role of insulin deficiency and growth hormone in severe retinopathy. | 2010 | 2863521 | |
| tromsø: lessons from a new curriculum. | 2010 | 2863501 | |
| elective testicular biopsy during chemotherapy for childhood leukaemia is of no clinical value. | the clinical value of early detection of testicular leukaemia was assessed by elective wedge biopsy during the 12th or 18th month of therapy in children with acute lymphoblastic leukaemia. biopsy samples were taken in 106 of 238 consecutively treated boys who attained complete remission; only 1 had occult disease. samples were also taken in 2 boys with testicular leukaemia at diagnosis as soon as they achieved complete remission, and in 14 others at the end of therapy; none showed evidence of le ... | 2010 | 2863443 |
| [physiological and pharmacologic studies of the adrenal medulla by the measurement of plasma catecholamine levels]. | the new techniques for the assay of the plasma catecholamines: noradrenaline, dopamine and, most importantly, adrenaline, because of their sensitivity and precision, have provided new information about the physiology and the pharmacology of the adrenal medulla in animals and in man. the most effective of these new techniques are the radioenzymatic techniques. the activation of the adrenal medulla in the dog or the rat appears to be frequency-dependent by maintaining a fixed concentration ratio i ... | 1985 | 2863423 |
| lymphatic transport of sodium cefoxitin in the presence of sodium 5-methoxysalicylate after injection into rat rectal connective tissue, femoral muscle and femoral vein. | lymphatic uptake of sodium cefoxitin after injection into rectal connective tissue was greater than after injection into the femoral muscle of rats. coadministration with sodium 5-methoxysalicylate enhanced lymphatic drug uptake at both sites. this enhancement may be an indirect result of 5-methoxysalicylate's suppression of vascular permeation of the cefoxitin. an adjuvant-induced increase in lymphatic fluid flow may also be partially involved in the enhancement of cefoxitin lymphatic transport ... | 1985 | 2863362 |
| mosquito breeding in water meter chambers. | 2010 | 2863184 | |
| non-o1 vibrio cholerae produces two newly identified toxins related to vibrio parahaemolyticus haemolysin and escherichia coli heat-stable enterotoxin. | 1985 | 2862364 | |
| photolabeling of mitochondrial f1-atpase by an azido derivative of the oligomycin-sensitivity conferring protein. | an azido derivative of the oligomycin sensitivity conferring protein (oscp) was prepared by alkylation with the bifunctional reagent p-azido phenacyl bromide. azido-oscp was fully biologically active in the dark. upon photoirradiation of a mixture of beef heart mitochondrial f1-atpase and azido-oscp, the resulting covalent photoproducts were separated by polyacrylamide gel electrophoresis in the presence of na dodecyl sulfate and characterized by an immunochemical procedure. oscp was found to re ... | 1985 | 2861814 |
| morphological characterization of the somatostatin-immunoreactive dendritic skin cells in urticaria pigmentosa patients by computerized image analysis. | by means of computerized image analysis, the somatostatin-immunoreactive epidermal and dermal dendritic cells of certain urticaria pigmentosa patients were characterized. the evidence obtained supported the concept that the epidermal cells correspond to the langerhans cells. | 2009 | 2860719 |
| morphological characterization of the somatostatin-immunoreactive dendritic skin cells in urticaria pigmentosa patients by computerized image analysis. | by means of computerized image analysis, the somatostatin-immunoreactive epidermal and dermal dendritic cells of certain urticaria pigmentosa patients were characterized. the evidence obtained supported the concept that the epidermal cells correspond to the langerhans cells. | 2009 | 2860719 |
| [current status of kidney transplantation and results]. | 2001 | 2860545 | |
| isolation of astrocytes, neurons, and synaptosomes of rat brain cortex: distribution of enzymes of glutamate metabolism. | a simplified method was developed for the bulk separation of neuronal perikarya and astroglial cells from adult rat brain without the involvement of density gradients. activities of various enzymes involved in glutamate metabolism were estimated and compared with those of synaptosomes. the activities of glutamate dehydrogenase and aspartate aminotransferase were higher in synaptosomes than in neuronal perikarya or glia. glutamine synthetase was distributed in all the three fractions while glutam ... | 1985 | 2859536 |