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an economical regimen of human diploid cell strain anti-rabies vaccine for post-exposure prophylaxis.vaccine regimens using 0.1 ml human diploid cell strain vaccine (hdcsv) given intradermally (id) in single and multiple sites, or with aluminum hydroxide adjuvant given subcutaneously (sc), were compared with the regimens of hdcsv and semple vaccine currently suggested by who. some groups were also given human rabies-immune globulin (hrig). neutralising antibody titres were monitored for 3 months. antibody was detected earliest in subjects given 0.1 ml hdcsv id at each of eight sites. the highes ...19836135830
structural proteins of fixed rabies virus in the suckling mouse brain.structural proteins of fixed rabies virus grown in the suckling mouse brain were analysed by sds-polyacrylamide gel electrophoresis (page). the relative content of g protein to l, n and m1 proteins of brain-grown virus was much lower when compared with that of the virus grown in chick embryo fibroblasts. the results indicate that nucleocapsid complexes, consisting of l, n and m1 proteins were the predominant antigens accumulating in the brain.19836135337
stability of human diploid cell rabies vaccines. 19836134059
rabies vaccine prepared from the virus grown in japanese quail embryo cell cultures.fixed rabies virus strain mniivp-74 was grown in japanese quail embryo cell cultures, concentrated by ultrafiltration and inactivated with beta-propiolactone. the resulting vaccine was markedly antigenic and immunogenic for laboratory animals. human volunteers injected with 2.0 ml vaccine on days 0, 3, 7, 14, 30 and 90 exhibited more intensive and longer antibody production than those injected daily for 14 days.19836133431
rabies. 19836132275
stability of human diploid-cell-strain rabies vaccine at high ambient temperatures.a batch of lyophilised human diploid-cell-strain rabies vaccine was divided into three batches, which were exposed to different temperatures during their distribution to and storage at three centres in pakistan. vaccine potency after exposure to these temperatures was tested by measuring antibody response in those given the vaccine, and by three different laboratory tests. the results indicate that the vaccine retains its antigenicity for man and for laboratory tests despite continuous exposure ...19836132229
viraemia in rabies. 19826127940
human rabies after late administration of human diploid cell vaccine without hyperimmune serum. 19826126724
commercial antirabies vaccine used as antigen in a modified enzyme-linked immunosorbent assay. 19826124116
properties of rabies vaccine freed of neuroallergenic factor from brain tissue.fixed rabies virus in the form of infected sheep brain suspension was freed from approx. 80% of ballast proteins, inactivated by beta-propiolactone and lyophilized. the vaccine thus obtained was devoid of neuroallergenicity when tested on guinea pigs and was highly antigenic and immunogenic. the vaccine caused no generalized reactions in volunteers; local reactions were weak and of short duration. antibody formation was intensive in all volunteers.19816118049
multisite intradermal antirabies vaccination. immune responses in man and protection of rabbits against death from street virus by postexposure administration of human diploid-cell-strain rabies vaccine.lymphocyte transformation, production of neutralising antibody, and the development of antirabies igg antibody were studied in ten healthy volunteers in response to 0.8 ml of human diploid-cell strain (hdcs) rabies vaccine administered on one occasion in divided doses in 8 intradermal (i.d.) sites. all ten volunteers rapidly developed substantial titres of rabies antibody, and eight of the ten had t lymphocytes that were immunologically stimulated by hdcs rabies-virus antigen. postexposure treat ...19816117693
purification and concentration of rabies virus by chromatography on chemically modified porous silicates.tissue culture rabies virus was purified by gel chromatography on chemically modified macroporous glasses (mpg). modification of the mpg surface by egg or human albumin prevented rabies virions from interaction with the glass surface so that all purified virus was eluted from the column. chemically modified mpg could be used on a preparative scale for the purification of both infectious and inactivated rabies virus, the immunogenicity of the latter having been preserved. protein content of the p ...19816116414
separation of two street rabies virus strain populations into two biological variants. 19816115568
freeing rabies virus of the neuroallergenic factor from brain tissue.a method of fixed rabies virus purification from infected sheep brains was proposed. it consisted of suspending the brain tissue in phosphate-buffered hypertonic (0.3 m) nacl solution, shaking at 37 degrees c and low speed centrifugation at the same temperature. from 65 to 85% ballast proteins were removed, the neuroallergenic activity of the material was lost, but practically no losses of the virus occurred.19816115564
rabies virus and laboratory regulations. 19816114354
rabies virus and laboratory regulations. 19816114274
rabies virus and laboratory regulations. 19816113412
rabies: a little antibody a dangerous thing? 19816112418
lagos bat virus in south africa. 19816111687
nonlethal infection of laboratory mice induced with "mouse" rabies strains.nonlethal infection was induced in laboratory mice with sublethal doses of rabies strains isolated from small wild rodents. three types of nonlethal infecion were observed: persistent--with virus irregularly reisolable for at least 56 days after inoculation: latent--with negative virus reisolation but presence of infection demonstrable by transmission of virus neutralization activity to other animals; and abortive--with only a primary immune response, nontransmissible to other animals. a hyperre ...19806108060
effect of 9-(s)-(2,3-dihydroxypropyl)adenine on experimental rabies infection in laboratory mice.9-(s)-(2,3-dihydroxypropyl)adenine (dhpa) exerted a pronounced influence on experimental rabies infection in laboratory mice. it was effective in a dose range from 1 to 100 mg/kg body weight. intracerebral infection tended to be potentiated, intramuscular infection was partly or fully inhibited by the drug. peroral administration was the most effective. the results of individual experiments varied and depended on the sensitivity of the virus strains employed, the dose of dhpa given and the time ...19806108059
protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene.inoculation of rabbits and mice with a vaccinia-rabies glycoprotein recombinant (v-rg) virus resulted in rapid induction of high concentrations of rabies virus-neutralizing antibodies and protection from severe intracerebral challenge with several strains of rabies virus. protection from virus challenge also was achieved against the rabies-related duvenhage virus but not against the mokola virus. effective immunization by v-rg depended on the expression of a rabies glycoprotein that registered p ...19846095272
frequency analysis of cytolytic t lymphocyte precursors (ctl-p) generated in vivo during lethal rabies infection of mice. ii. rabies virus genus specificity of ctl-p.cytolytic t lymphocyte precursors (ctl-p) were sensitized in vivo by intraplantar infection of c57bl/6 mice with a lethal dose of rabies virus, strain era (era). as a result of sensitization ctl-p matured to interleukin-receptive ctl-p (il-ctl-p) that could be expanded in vitro to thy-1+, lyt-2+ ctl clones in the presence of il without subjection to antigen-driven selection. after infection with era, il-ctl-p-derived ctl lysed fibroblasts infected with rabies virus but not those infected with an ...19846094202
role of phospholipids in rhabdovirus attachment to cer cells. brief report.the effect of phospholipases on rhabdovirus attachment to cer cells and the competitive binding of phospholipids and viruses to cells were studied. results obtained indicate that, although to a different extent, some phospholipids represent a binding site for both vesicular stomatitis virus (vsv) and rabies virus.19846089706
[rabies in humans--confirmation of the existence of fast intra-axonal circulation in peripheral nerves]. 19846085743
[antigenic characteristics of strains of rabies isolated in madagascar]. 19846085460
characterization of rabies virus strains used for vaccine production by means of monoclonal antibodies.a group of who consultants who met in geneva 16-18 september 1982, recommended, among other items, that "monoclonal antibody reactivity pattern of all viruses used for (rabies) vaccine production should be established" (who/rab.res./82.15) (1). such a study has been undertaken in our who collaborative centre for rabies in close collaboration with the who collaborative centre for rabies of the wistar institute, and with monoclonal antibodies kindly supplied by t.j. wiktor (2).19846084613
investigation of the antigenic structure of rabies virus glycoprotein by monoclonal antibodies.comparative antigenic analysis of glycoprotein variants of era and cvs-11 strains of rabies virus by monoclonal antibodies has permitted the delineation of three antigenic sites on the glycoprotein common to both strains. two additional antigenic sites have been delineated on the era strain virus glycoprotein. the topologic relationship of these antigenic sites has been investigated.19846084612
monoclonal antibodies as a tool for rabies epidemiological studies.hybridoma-produced monoclonal antibodies specific of antigenic determinants of the nucleocapsid and the glycoprotein of rabies virus showed differences between fixed and street strains of rabies virus. standard panels of monoclonal antibodies allowed us to determine the geographic origin of imported cases of rabies in animals and humans.19846084611
influence of lipogenesis on growth of rabies virus in brown adipose adipose tissue of experimentally infected hamsters. 19676078218
separation of 'soluble' immunoprecipitating antigens originating from rabies virus infected cells by chromatography on ecteola cellulose and by gel filtration. 19676076336
experimental rabies infection in the mexican freetail bat. 19676067473
[antirabies vaccinations at the institut pasteur of lyon in 1966]. 19676065946
comparative studies between pathogenesis of street and fixed rabies infection.comparative neuropathology of ammon's horn caused by both the street and fixed rabies infection was studied by combined light and electron microscopy. neurons containing negri bodies appeared comparatively little damaged. in striking contrast, in the case of fixed virus infection, neurons showed the following variety of degeneration. lightly damaged neurons showed an increase in the number of small vesicles throughout the cytoplasm. a considerable number of lysosomes were also encountered within ...19676016898
[effect of deoxyribonuclease on rabies virus]. 19666014608
[rabies in an insectivorous bat (rogheessa tumida tumida h. allen)]. 19666013772
[on the isolation in brazilof rabies virus from the lung, heart and various other tissues of hematophagous vampire bats belonging to the species desmodus rotundus]. 19666011926
[rabies, present-day disease]. 19666010705
rabies in tennessee swine. 19666006429
[a study of the stabilizing effect of a copolymer of vinyl alcohol and vinylamine on fixed rabies virus during its purification with freon]. 19666002943
[multiplication of street rabies virus in primary culture of puppy kidney cells]. 19666002853
[on the cytopathogenic effect of street rabies virus]. 19666002363
[experimental studies on the problem of rabies transmission by flies]. 19665998339
[use of human chromosomes for the investigation of the cytopathic effect of rabies virus]. 19665992754
[studies on the rabies virus in relation to insects. changes in virus fixé of rabies due to passage through larvae of the gypsy moth (porthetria dispar l)]. 19665992406
"soluble" antigens from cells infected with rabies virus. 19665988229
interferon production in hamsters experimentally infected with rabies virus. 19665958999
brain neutralization of rabies virus to distinguish recovered animals from previously vaccinated animals. 19665955831
[do the properties of a fixed rabies virus change in extracerebral passage?]. 19665954721
autointerference of rabies virus in chick embryo fibroblasts. 19665951071
alloxan-schiff reagent for the detection of fixed rabies virus in the nerve cell. 19665944358
[apropos of the formation of intermediate antigens in nervous tissue, infected by the fixed rabies virus]. 19665944295
density gradient centrifugation studies on rabies virus.neurath, a. robert (the wistar institute, philadelphia, pa.), tadeusz j. wiktor, and hilary koprowski. density gradient centrifugation studies on rabies virus. j. bacteriol. 92:102-106. 1966.-cesium chloride density gradient centrifugation of rabies virus revealed a heterogeneous population of infectious virus particles, the majority of which showed a density of 1.20 g/ml. from results obtained by rate zonal centrifugation in preformed sucrose gradients, it was possible to calculate a sedimentat ...19665941269
kinetic studies on growth of rabies virus in tissue culture. ii. the replication cycles in rabies virus infection. 19665930491
kinetic studies on growth of rabies virus in tissue culture. i. cell virus interaction. 19665930490
pathogenesis of skunk rabies virus: quantitation in skunks and foxes. 19665913037
transmission experiments with bat rabies isolates: reactions of certain carnivora, opossum, rodents, and bats to rabies virus of red bat origin when exposed by bat bite or by intrasmuscular inoculation. 19665913032
transmission experiments with bat rabies isolates: reaction of certain carnivora, opossum, and bats to intramuscular inoculations of rabies virus isolated from free-tailed bats. 19665913022
transmission experiments with bat rabies isolates: responses of certain carnivora to rabies virus isolated from animals infected by nonbite route. 19665913020
[rabies in a wide-winged bat (eptesicus serotinus) in thuringia]. 19655894962
chiropteran (bat) rabies in north america. 19655891616
[agar gel precipitation test in laboratory animals inoculated with the rabies virus]. 19655882915
further contributions to knowledge of the time during which rabies virus is bound. 19655882413
[on the role of the rabies virus in the etiology of multiple sclerosis and encephalomyelitis]. 19655876802
[pathogenesis of allergic complications caused by viruses. i. development of infection in mice given repeated sublethal doses of fixed rabies virus]. 19655874471
adaptation of rabies street virus strains to tissue culture. 19655850012
detection of a lymphocytic choriomeningitis component in rabies virus preparations. 19655848338
[contribution to the disinfection of fixed rabies virus with chemicals]. 19655842572
growth characteristics of rabies virus in primary chick embryo cells. 19655840891
[study of the fixed rabic virus cultivated on various cells of canine origin (louis pasteur strain)]. 19655838638
[on the problem of transmission of the rabies virus by bloodsucking ectoparasites]. 19655832256
[experimental studies on rabies in ethiopia]. 19655827406
[pathology of the experimental rabies encephalitis with fixed virus in cats]. 19695821312
sinus worm skrjabingylus spp. (nematoda: pseudaliidae) from rabid skunks (mephitis mephitis) in california. 19695815929
rabies. 19695815668
biochemical and biophysical studies on the nucleocapsid and on the rna of rabies virus. 19695803947
[infection with food-borne rabies virus in experimental conditions]. 19695803035
[serologic response of vaccinated persons against rabies using fuenzalida type vaccine]. 19695802753
use of beta-propiolactone in duck embryo rabies vaccine. 19695798765
immunogenicity of concentrated and purified rabies vaccine of tissue culture origin. 19695791793
viral subunits for rabies vaccination. 19695775839
rabiesvirus neuronitis. 19695774142
the time for which rabies virus can survive locally before its introduction into the central nervous system. 19695770640
a contribution to the knowledge of direct peripheral communication with the central nervous system using a strictly neurotropic rabies virus as a model. 19695770639
protracted survival of a rabies-infected insectivorous bat after infective bite. 19695764199
use of synthetic media for the cultivation of rabies virus in tissue culture. 19685760882
a trial to develop a purified antirabies vaccine. 19685759963
hemagglutination by rabies virus.goose erythrocytes were agglutinated by five strains of rabies virus grown in monolayer cell cultures at ph 6.4 and at 0 to 4 c. hemagglutination was not affected by the cell type in which the virus was grown. prerequisites for occurrence of hemagglutination are absence of hemagglutination inhibitors (such as those contained in bovine serum) and a relatively high virus concentration (> 10(6) plaque-forming units of virus per ml). "soluble" hemagglutinin was not present in crude preparations of e ...19685754504
[alarm against rabies]. 19685754109
purification and partial chemical analysis of rabies virus of tissue culture origin. 19685753955
propagation of rabies virus strains in chick embryo tissue culture. 19685753954
immune lysis of rabies virus-infected cells. 19685749193
[study of the kinetics of rabies virus in intracerebrally inoculated mice]. 19685746277
[effect of 1-amino adamantane on reproduction of fixed rabies virus in tissue culture]. 19685733228
[considerations on the biology of rabies]. 19685730085
changes in the central nervous system after experimental rabies infection and immunization. 1. an electroencephalographic study. 19685728275
[rapid changes of the pathogenicity for the adult mouse of a special avianized variant of rabies fixed virus of the sassari strain]. 19685716646
[sensitivity of some laboratory animals to rabies fixed virus of the sassari strain and to the avianized variants]. 19685716645
19 s neutralizing antibody produced in guinea pigs by rabies virus. 19685712546
[formation and effect of interferon in experimental infections with fixed rabies virus]. 19685708930
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