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murine malaria. iv. disturbed immunological responsiveness during plasmodium berghei infection. 19714945431
studies of splenomegaly in rodent malaria. ii. the course of splenomegaly, igm, igg levels and igg immunofluorescent antibody titre in mice after infection with plasmodium berghei yoelii and-or plasmodium chabaudi. 19714938408
immunologic enhancement in malaria infection (plasmodium berghei). 19714933405
[demonstration by fluorescent antibody technic of serum antibodies in white rats inoculated with plasmodium berghei]. 19694933046
propagation of plasmodium berghei and p. vinckei in mouse erythrocytes injected into chick embryos. 19704919090
further studies on the plasmodium berghei-anopheles stephensi--rodent system of mammalian malaria. 19684919047
studies concerning the mechanism of action of antimalarial drugs. inhibition of the incorporation of adenosine-8-3h into nucleic acids of plasmodium berghei. 19694895016
plasmodium berghei infection in thymectomized rats. 19694893115
[biologic cycle in the laboratory of plasmodium berghei killicki n. sub. sp]. 19684888201
aminoacyl transfer ribonucleic acid synthetases from cell-free extract of plasmodium berghei.aminoacyl transfer ribonucleic acid synthetases for leucine tyrosine, histidine, valine, proline, threonine, and lysine were obtainnned from cell-free extract of plasmodium berghei. the leucyl-trna synthetase cane charge trna from liver or escherichia coli with leucine-c(14), liver trna being a better substrate. the amount of aminoacylation increses linerly with respect to the quantity of trna added from either source and is dependent on the amount of enzyme added. the rate of aminoacylation is ...19694888104
endotoxin-induced modification of plasmodium berghei infection in mice. 19694885402
[nucleic acid metabolism in experimental malaria. 2. incorporation of adenosine and hypoxanthine into the nucleic acids of malaria parasites (plasmodium berghei and plasmodium vinckei)]. 19684878204
active immunization against malaria (plasmodium berghei). i. definition of antimalarial immunity. 19684878202
[changes in the dna content of spleen cells in vitro as a result of experimental malaria infection (plasmodium berghei)]. 19674877818
[the importance of p-aminobenzoic acid to the course and immunity of malaria in animals (plasmodium berghei) and in man (pl. falciparum). 3. studies on children experimentally fed on milk]. 19664866993
[the importance of p-aminobenzoic acid to the course and immunity of malaria in animals (plasmodium berghei) and in man (pl. falciparum). ii. studies on naturally fed small children]. 19664866992
serological cross-reaction between rodent malaria parasites as determined by the indirect immunofluorescent technique.in view of the morphological similarity between the blood stages of plasmodium berghei berghei and p. b. yoelii on the one hand and p. vinckei and p. chabaudi on the other, these rodent malaria parasites were investigated by the indirect fluorescent antibody technique in the hope of thus differentiating between them.sera were obtained from rats hyperimmunized against these four parasites, from rabbits immunized against the soluble antigens of the blood stages of the parasites, and from a rabbit ...19674864305
morphological effects of chloroquine on plasmodium berghei in mice. 19674861556
pathophysiological observations on blood of rats infected with plasmodium berghei. 19734800051
[interferon and protection of the mouse against experimental infestation transmitted by the erythgrocytic forms of plasmodium berghei injected in massive doses. ii. effects of several immunosuppressive agents on protection patterns by a viral interferon inducer]. 19734771733
rigidity of red cell during malarial infection. 19734632768
2,4-diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 3. synthesis of 5,6-disubstituted derivatives and related tetracyclic analogs. 19734632695
2,4-diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 2. synthesis of 2,4-diaminopyrido(4',3':4,5)thieno(2,3-d)pyrimidines and 2,4-diamino-8h-thiopyrano(4',3':4,5)thieno(2,3-d)pyrimidines. 19734632694
2,4-diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 1. synthesis of 2,4-diamino-5,6,7,8-tetrahydrothianaphthena(2,3-d)pyrimidines and related compounds. 19734632693
second roundtable discussion on taxonomic problems relating to malaria parasites. 19734632261
folate antagonists. 9. 2,4-diamino-6-((aralkyl)alkylamino)quinazolines, a potent class of antimetabolites with prodigious antimalarial effects. 19724631920
infectivity of plasmodium berghei and of babesia rodhaini to various primates. 19734631764
the challenge of drug-resistant malaria. 19734631761
absence of immunity between trypanosoma musculi and intra-erythrocytic protozoa in mice. 19724629793
immunity to malaria and piroplasmosis in mice following low level infections with anthemosoma garnhami (piroplasmea: dactylosomidae). 19724629792
protective heterologous immunity between plasmodium atheruri and other plasmodium spp. and babesia spp. in mice. 19724629791
synthesis of some bis(2,4-diaminopyrimidines) and bis(2,4-diaminoquinazolines) as potential antimalarial agents. 19724629015
folic acid analogs. modifications in the benzene-ring region. 2. thiazole analogs. 19724629013
lincomycin. 14. an improved synthesis and resolution of the antimalarial agent, 1'-demethyl-4'-depropyl-4'-(r)- and -(s)-pentylclindamycin hydrochloride (u-24, 729a). 19724629012
antibody and immunoglobulin synthesis in germfree and conventional mice infected with plasmodium berghei. 19724627628
studies of splenomegaly in rodent malaria. 3. protein calorie malnutrition and splenomegaly in mice infected with plasmodium berghei yoelii. 19724625993
[studies on the mechanism of action of a viral inducer of interferon in the protection of mice against massive infestation by endoerythrocytic forms of plasmodium berghei]. 19724624949
demonstration of malarial antigens in the sera of plasmodium berghei-infected mice. 19724622282
immunity to plasmodium berghei in rats: maximum levels of protective antibody activity are associated with eradication of the infection. 19724622015
purification and characterization of phosphoenolpyruvate carboxylase from plasmodium berghei.phosphoenolpyruvate (pep) carboxylase was purified over 400-fold from plasmodium berghei. the purified enzyme was stable in 0.4 m potassium phosphate buffer (ph 7.4) containing 0.5 m glucose, 1 mm ethylenediaminetetraacetic acid (edta), and 1 mm mgcl(2). it had a molecular weight of 280,000 determined by sucrose density gradient centrifugation in this buffer, but it aggregated and was unstable in the presence of different salts or a more dilute solution of potassium phosphate. the k(m) for pep w ...19724621631
[immunodepression vis-a-vis anti-whooping cough vaccine in mice infested with plasmodium berghei yoelii]. 19724620615
[characterization of the antigen produced by solubilization of cell membranes of plasmodium berghei]. 19744620172
[research on congenital plasmodium berghei berghei malaria in mice. transplacental passage of the parasite and its evolution]. 19744619061
prevention of drug resistance in rodent malaria by the use of drug mixtures.development of resistance to chloroquine in rodent malaria is inhibited by giving this compound together with a potentiating mixture of pyrimethamine and sulfadoxine but this does not prevent the development of resistance to the last two compounds. the use of drug mixtures should be explored as a means of "protecting" chloroquine or new blood schizontocides intended for mass chemotherapy against human malaria. however, no general rule can be laid down without testing specific drug mixtures in lo ...19744619060
modification by a latent contaminant of glomerular pathology in mice infected with plasmodium berghei.this study was designed to determine, by means of electron microscopy, the effect of latent contaminants-which are associated with the syringe passage of the parasite-on the findings in the glomeruli of p. berghei-infected mice. a rapid alteration of the glomerular basement membrane was observed in mice infected with the syringe-transmitted n strain, but not in those infected with the cyclically passaged nig strain. glomerular changes were also seen in mice inoculated with nonparasitized blood f ...19744619058
[evaluation of anti-plasmodium antibodies in idiopathic african splenomegaly]. 19744618790
[immunological aspects of plasmodium berghei infections (action of cortisone in therapeutic doses)]. 19744618434
development and decline of antiplasmodial indirect fluorescent antibodies in mice infected with plasmodium berghei (nk65) and treated with drugs.malaria parasites in mice present a simplified rodent model for the immunological study of malaria. experiments have been performed to determine the pattern and persistence of malaria antibody as detected by the indirect fluorescent antibody (ifa) test utilizing specific antimouse igm and igg conjugates. the antibody levels in mice inoculated with plasmodium berghei and treated with antimalarial drugs were traced after complete elimination of the parasites from the host. within 1-2 weeks after i ...19744617640
effect of hypothyroidism on parasitemia and survival in rodent malaria. 19744617503
erythrocyte atp levels in mice infected with plasmodium berghei malaria. 19744617309
the selection of arylamidinourea antimalarials by their predicted physicochemical properties.1 a small group of arylamidinoureas for which the predicted physicochemical properties were widely spaced and uncorrelated was selected for study.2 the antimalarial activity of each compound was measured against three species of plasmodium. three corresponding regression equations were calculated relating the potency of each compound to its predicted physicochemical properties.3 the potency of further test compounds was forecast for each species, by using the corresponding regression equation. t ...19744615765
suppression of schistosome granuloma formation by malaria in mice.plasmodium berghei yeolii infection in mice suppressed granuloma formation around schistosoma mansoni eggs in the lungs. this suppressive effect was observed as early as 4 days after schistosome eggs were injected into malaria-infected mice and the maximum suppressive effect was seen by the 16th day. at this time granulomas in control mice than in mice infected with malaria. these data suggest that malaria has a direct influence on an immunologic reaction of the delayed hypersensitivity type. th ...19744615597
the uptake and incorporation of nucleosides into normal erythrocytes and erythrocytes containing plasmodium berghei. 19744615289
the effect of plasmodium berghei and trypanosoma brucei infections on the immune expulsion of the nematode trichuris muris from mice. 19744615070
acid hydrolases of the sporogonic stage of plasmodium berghei nigeriensis. 19744614726
ultrastructural studies on the early ookinete stage of plasmodium berghei nigeriensis and its transformation into an oocyst. 19744614723
[treatment of drug-resistant malaria: animal experiments]. 19744613506
malaria and the permeability of the host erythrocyte. 19744612377
plasmodium berghei ookinete formation in a nonvector cell line. 19744612127
immunity to plasmodium berghei in rats: passive serum transfer and role of the spleen.pools of rat antiserum to plasmodium berghei had different levels of protective activity as assessed by a passive transfer test. preincubation of parasite inocula with an effective pool before injection did not significantly enhance protective activity. removal of the antiserum from preincubated parasite inocula abolished the bulk of protective activity. similarly, antiserum effective in intact animals was largely ineffective in splenectomized recipients. these experiments suggest a minimal role ...19744611920
comparison of the effects of neonatal thymectomy on plasmodium berghei, trypanosoma lewisi and trypanosoma cruzi infection in the albino rat. 19744611081
influence of allopurinol on the multiplication of rodent malaria parasites. 19744610931
host-cell specific proteolytic enzymes in plasmodium berghei infected erythrocytes. 19744610782
babesia microti and plasmodium berghei yoelii infections in nude mice. 19744610411
in vitro ookinete development of the rodent malarial parasite, plasmodium berghei. 19744610107
erythropoietin production in virulent malaria.erythropoietin, the hormone responsible for stimulating erythrocyte production, was shown to increase significantly in the serum of mice during virulent malaria infection. although erythropoiesis was enhanced, it did not keep pace with the rate of erythocyte destruction; hence all plasmodium berghei-infected mice quickly succumbed to the deleterious consequences of severe uncompensated hemolytic anemia. since this apparently inadequate rate of erythropoiesis is not attributed to impaired erythro ...19744609912
an experimental approach to the demonstration of a single generation of exo-erythrocytic schizonts in plasmodium berghei. 19744609378
synthesis and antimalarial evaluation of 9,10-dihydrophenanthrene amino alcohols. 19744608227
letter: relation between plasmodium berghei and hepatosplenic and blood rates of paba and folates in mice. 19744608060
proceedings: the interaction between an ascites tumour and rodent malarias in mice. 19744607934
proceedings: the effect of mouse haemoglobins of plasmodium berghei and babesia rodhaini infections. 19744607933
selections of anopheles gambiae species a for susceptibility and refractoriness to malaria parasites. 19744607768
variation in glutamate dehydrogenase in subspecies of plasmodium berghei. 19744607629
slow maturing primary exo-erythrocytic schizonts of plasmodium berghei in an experimentally infected tree-rat (thamnomys surdaster). 19744607414
scanning electron microscope observations of plasmodium berghei ookinetes in primary mosquito cell cultures. 19744607047
quinazolines. 12. 1,3-diaminobenzo(f)quinazolines containing long-chain alkyl or chloro substituents on the central ring. synthesis and biological evaluation as candidate antifolate and antimalarial agents. 19744606974
plasmodium berghei: possible role of thyroxine in growth and metabolism. 19744606914
plasmodium berghei berghei: ectopic development of the anka strain in anopheles stephensi. 19744606913
chemotherapy of rodent malaria: transfer of resistance vs mutation. 19744606333
antimalarials. 4. tetrahydroquinolinemethanols. 19744606233
amodiaquine analogs. synthesis of 6-((3-(n,n-diethylamino)methyl-4-hydroxy)anilino)5,8-dimethoxy-2,4-dimethylquinoline and related compounds. 19744606204
a structural modification study of the antimalarial 2-(p-chlorophenyl)-2-(4-piperidyl)tetrahydrofuran. 19744606154
synthesis and screening of potential antimalarial agent alpha-(2-piperidyl)-2-(1-adamantyl)-6,8-dichloro-4-quinolinemethanol hydrochloride. 19744605197
the surface of the malaria parasite. i. scanning electron microscopy of the oocyst. 19744602986
dihydropteroate synthetase from plasmodium berghei: isolation, properties, and inhibition by dapsone and sulfadiazine. 19744602912
fluorescent-antibody cross reactions between four blood parasites. 19744602679
the chemotherapy of rodent malaria, xix. the action of a tetracycline derivative, minocycline, on drug-resistant plasmodium berghei. 19744602012
synthesis of analogs of 6-arylthio-, 6-arylsulfinyl-, and 6-arylsulfonyl-2, 4-diaminoquinazolines as potential antimalarial agents. 19744600305
ultrastructural analysis of plasmodium berghei sporozoite antigens prepared by freeze thawing and heat inactivation. 19744600225
the mitochondria of pre-erythrocytic plasmodium berghei. 19744600125
high-affinity accumulation of chloroquine by mouse erythrocytes infected with plasmodium berghei.washed erythrocytes infected with chloroquine-susceptible (cs) or with chloroquine-resistant (cr) p. berghei were used in model systems in vitro to study the accumulation of chloroquine with high affinity. the cs model could achieve distribution ratios (chloroquine in cells: chloroquine in medium) of 100 in the absence of substrate. 200-300 in the presence of 10 mm pyruvate or lactate, and over 600 in the presence of 1 mm glucose or glycerol. in comparable studies of the cr model, the distributi ...19744600044
antimalarial, antiamoebic and toxicity tests on gentianine. 19744599567
potential antimalarials. 8. some 10-substituted 9-phenanthrenemethanols. 19744599520
effective recovery and immunity to virulent malaria following red cell transfusion at crisis. 19744599485
antimalarials. 2. alpha-di-n-butylaminomethyl-2-(p-chlorophenyl)-5-quinazolinemethanol. 19744598262
synthesis and antimalarial activity of anthracene amino alcohols. 19744598134
antimalarials. 6. synthesis, antimalarial activity, and configurations of racemic alpha-(2-piperidyl)-4-pyridinemethanols. 19744598133
naphthothiophenes. 4. preparation of multisubstituted 4-naphtho(2,1-b)thiophenemathanols and the effect of side chain modification on antimalarial activity of 8-trifluoromethyl-4-naphtho(2,1-b)thiophenemethanols. 19744598132
synthesis of potential antimalarial agents. preparation of some 6-amino-5,8-dimethoxyquinolines and the corresponding 6-amino-5,8-quinolinediones. 19744598023
chemotherapeutic activity of combination doses of chloroquine, pyrimethamine, and sulfamethoxy-diazine, a long-acting sulfanilamide, against plasmodium berghei infections in mice.during the course of antimalarial screening, it was discovered that sulfamethoxydiazine, a long-acting sulfanilamide extensively used in genitourinary tract infections, not only was effective against plasmodium berghei infections in mice when administered alone but also was active when used in combination with chloroquine, in effect making it possible to use half as much of the latter drug as normally required to achieve the same results. the triple combination of chloroquine, sulfamethoxydiazin ...19734597722
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