Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| "xenogeneic resistance" to rat bone marrow transplantation. iii. maturation age, and abrogation with cyclophosphamide, corynebacterium parvum and fractionated irradiation. | lethally irradiated c57 bl/6 mice and (c57 x a) f1 hybrids fail to accept doses of rat bone marrow cells (5 x 10(6)) which give confluent splenic repopulation in "non-resistant" strains of mice. this phenomenon has been termed "xenogeneic resistance" (xr). xr in (c57 x a) f1 mice can be overridden by a very large inoculum of rat bone marrow (26 x 10(6) cells). xr is not manifest in mice of a resistant strain at ages of 18 days or younger, but is manifest at ages of 22 days and older. xr can be a ... | 1976 | 773442 |
| the role of macrophages in the adjuvant effect on antibody production of corynebacterium parvum. | spleen cells from mice pre-treated with c. parvum gave an enhanced in vitro antibody response to srbc, but not to dnp-pol. this enhancing activity was associated with the adherent, but not the non-adherent spleen cell population and was found to be radioresistant. it is concluded that macrophages are directly involved in the adjuvant effect of c. parvum and the possible mechanisms of action are discussed. | 1976 | 770033 |
| bacillus calmette-guérin immunotherapy in combination with dtic (nsc-45388) for the treatment of malignant melanoma. | combination studies of immunotherapy and dtic chemotherapy for patients with malignant melanoma are described. at our institute the combination of bacillus calmette-guérin (bcg) with dtic, or dtic plus methyl-ccnu, has resulted in augmentation of remissions in areas regional to bcg immunization, prolongation of chemotherapy-induced remissions, and significant prolongation of survival compared to the use of dtic chemotherapy without immunotherapy. data from other centers have shown that augmentat ... | 1976 | 769970 |
| phase i study of corynebacterium parvum in patients with solid tumors. | nineteen patients with various solid tumors were treated with corynebacterium parvum for 10 consecutive days at doses ranging from 0.5 to 6 mg/m2. major toxic effects included rigors and cyanosis, hypertension, headache, nausea, and vomiting. toxicity was maximal during the first 3 days of treatment and decreased or even disappeared when, on subsequent days, increasing doses of the vaccine were given. objective tumor regressions were observed in four patients. | 1975 | 769953 |
| nonspecific immunotherapy by corynebacterium parvum: phase i toxicity study in 12 patients with advanced cancer. | corynebacterium parvum, a non-specific immunopotentiator, was administered intravenously to 12 patients with advanced cancer at 2, 3, and 4 mg/m2 dose levels in combination with radiation therapy. one dose of c. parvum was given every 7 days for a total of 4 doses in 21 days. symptoms and signs developed by these patients for a period of 3 to 6 hours during and shortly after the i.v. infusion of the first dose of c. parvum were moderately severe in nine patients and mild in three patients. for t ... | 1976 | 769937 |
| immunogenicity of a rat leukaemia of spontaneous origin (sal). | the sal rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained using stimulation of the res or by immunization with sal cells exposed to x-rays, nitrogen mustard, iodoacetate or glutaraldehyde. however, immunization with sal cells exposed to low doses of mitomycin-c slowed the growth of the challenge inoculum. cells treated with high doses of mitomycin-c did not imm ... | 1976 | 769814 |
| immunology and lung cancer. | carcinoma of the lung is the number one cancer killer in the united states. the overall cure rate is about 10%, and although resection is the best treatment available, five-year survival following operation is only 25%. recent studies have shown that patients with lung cancer are immunosuppressed but that pulmonary tumors do contain tumor-associated antigens. studies of other human tumors indicate that immunotherapy can augment tumor immunity and can be an effective surgical adjuvant. this commu ... | 1976 | 769714 |
| proceedings: the effect of bacille calmette-guérin (bcg) and corynebacterium parvum on the development of spontaneous mouse mammary carcinoma. | 1976 | 766891 | |
| serum lysozyme as a marker of host resistance. i. production by macrophages resident in rat sarcomata. | with progressive growth of syngeneic sarcomata in rats there was a rise in serum levels of lysozyme which correlated with their immunogenicity and their macrophage content. by an examination of lymph/blood differences in normal and in tumour bearing rats and of the production of lysozyme by cells obtained from the tumours and maintained in vitro, it is apparent that the macrophages resident in a tumour mass make a massive contribution to the elevation in serum lysozyme concentrations. tumour cel ... | 1976 | 766806 |
| proceedings: influence of cornyebacterium parvum and of anti-lymphocyte serum (als) on bone marrow transplantation in small rodents. | 1975 | 766804 | |
| effects of dose and schedule of immune stimulant on efficacy of combination corynebacterium parvum-cyclophosphamide treatment for a murine mammary adenocarcinoma. | certain variables which might influence the outcome of combining cytotoxic drug and immune stimulant therapy were studied to optimize the effectiveness of corynebacterium parvum combined with cyclophosphamide (cy) as treatment for a murine mammary adenocarcinoma (cad2). optimal effects of combined c. parvum-cy treatment in the cad2 system were obtained when 443 to 1400 microgram of this immune stimulant per mouse were injected 2 to 3 days after cy chemotherapy and when combination treatment was ... | 1979 | 761179 |
| selective antibacterial action of 2-mercaptoethanol on propionibacteria in skin cultures. | 2-mercaptoethanol applied to the surface of agar medium had a selective antibacterial effect on propionibacterium acnes and propionibacterium granulosum without interfering with the growth of peptococcus saccharolyticus or staphylococci in anaerobic cultures of skin or in pure cultures. in aerobic broth culture, 2-mercaptoethanol inhibited aerobes and stimulated anaerobes, consistent with its action as a reducing agent. | 1979 | 760636 |
| effect of corynebacterium parvum on hemopoietic stem-cell kinetics. | the intravenous administration of 548 microgram of killed corynebacterium parvum (c. parvum) into c57bl mice leads to a significant decrease in the number of bone-marrow colony-forming-units in spleen (cfus) as early as 12 h after the injection of the bacterium. this decrease persisted in varying degrees for 3 weeks. after an initial fall at 24 h, the splenic cfus exhibited a rapid expansion and reached values 10 times higher than the control range on the ninth day. a significant rise in the num ... | 1979 | 759377 |
| studies on resistance to marek's disease tumorigenesis: effect of immune stimulation, tumour-cell vaccines, and herpesvirus of turkeys on tumour immunity. | 1978 | 751899 | |
| local corynebacterium parvum therapy in early breast cancer: a pilot study. | 1978 | 750126 | |
| a bladder tumor model response to immunotherapy. | the author presented results of bcg and corynebacterium parvum treatment of the transplantable mouse fanft bladder tumor carried in the host's leg. a comparison was made of the results of treatment with bcg alone and c. parvum alone or either used in conjunction with cytoxan upon effectiveness in increasing animal survival and retarding tumor growth. | 1978 | 748789 |
| purification and properties of a bacteriocin-like substance (acnecin) of oral propionibacterium acnes. | propionibacterium acnes cn-8, isolated from human dental plaque, was grown in a liquid medium, and its bacteriocin-like substance (acnecin) was extracted from the cells by ultrasonic treatment. acnecin was purified to a homogeneous state with recovery of 47%. specific activity increased 72-fold in comparison with the crude extract. the properties of acnecin were as follows. (i) acnecin may consist of five subunits with a molecular weight of about 12,000. (ii) its isoelectric point was 5.5. (iii) ... | 1978 | 742876 |
| studies on putative adult worm-derived vaccines and adjuvants for protection against schistosoma mansoni infection in mice. | intraperitoneal transfer of viable adult worms of schistosoma mansoni did not confer protection against a challenge infection to recipient mice. antigens of schistosome origin were evaluated for their ability, with and without concomitantly administered nonspecific adjuvants, to stimulate protective immunity against s. mansoni. freshly perfused ground worms or a putative membrane antigen extracted with 0.5 m kc1 from adult worms, when injected together with corynebacterium parvum (or in a single ... | 1978 | 739318 |
| propionibacteria as a cause of shunt and postneurosurgical infections. | propionibacterium acnes was isolated from postoperative specimens from nine neurosurgical patients. the role of p. acnes in postneurosurgical infection is discussed. | 1978 | 739055 |
| saprophytic bacterial flora in the sebaceous gland infundibulum in diabetes mellitus. | 1978 | 736608 | |
| effect of topical application of dexamethasone on propionibacteria in the pilosebaceous duct. | a preparation of dexamethasone 0.02% in eutanol g (n octyldodecanol) was applied once daily for three weeks, to the right side of the forehead of 25 male healthy test subjects. eutanol g without dexamethasone was applied in the same way to the left side of the forehead. before and at the end of the treatment period bacteria were removed from the pilo-sebaceous ducts by the method of holland et al. [8]. bacteria that grew under anaerobic conditions were evaluated quantitatively. dexamethasone ind ... | 1978 | 729607 |
| comparative effects of corynebacterium parvum, brucella abortus extract, bacillus calmette-guérin, glucan, levamisole, and tilorone with or without cyclophosphamide on tumor growth, macrophage production, and macrophage cytotoxicity in a murine mammary tumor model. | in this laboratory, it has been repeatedly demonstrated (using a murine mammary tumor model) that the combination of cyclophosphamide (cy) and corynebacterium parvum (cp) is more effective than either agent alone in the control of tumor growth. this paper presents information obtained in our model comparing findings on the effects of cp with a brucella abortus extract (bru-pel; bp) and glucan (gl) on tumor growth. in addition, the influence of those agents as well as bacillus calmette-guérin, ti ... | 1978 | 728912 |
| effect of glucan and other adjuvants on the clearance of radiolabeled tumor cells from mouse lungs. | the iv injection of two forms of glucan (diluzio and yamamura), corynebacterium parvum, or bacillus calmette-guérin (bcg) caused a significant increase in the rate and extent of clearance of subsequently injected radiolabeled t1699 carcinoma cells from the lungs of syngeneic dba2 mice. dose-response curves were obtained for each agent, the relative rates of clearance of radiolabeled cells were established, and preliminary sequential comparative studies were undertaken. the optimum dose for c. pa ... | 1978 | 728905 |
| propionicins, bacteriocins produced by propionibacterium avidum. | one hundred strains of propionibacterium acnes, granulosum and avidum were tested for susceptibility toward bacteriocins produced extracellularly by eight strains of propionibacterium avidum. some bacteriocin-producing strains were inhibitory for all strains tested. a name propionicins, is proposed for bacteriocins produced by p. avidum. | 1978 | 726736 |
| differential susceptibility of propionibacterium acnes, p. granulosum and p. avidum to free fatty acids. | the susceptibility of 98 propionibacterium acnes, p. granulosum and p. avidum strains isolated from acne cases and appropriate reference strains to decanoic, dodecanoic, octadeca-9,12 dienoic, and octadeca-9,12,15 trienoic acids was investigated using minimal inhibitory concentration estimation by an agar dilution techique. the tested acids showed their relative antibacterial activity in the following order: c18:3 delta 9,12,15 greater than c18:2 delta 9,12 greater than c12:0 greater than c10:0 ... | 1978 | 722112 |
| electron capture gas-liquid chromatographic study of metabolites produced by some arthritic transudate-associated organisms in vitro and in vivo in rabbit models. | computerized, frequency-pulsed, modulated electron capture gas-liquid chromatography was used to study the acid metabolites produced in vitro in fetal calf serum and in vivo in an animal chamber model. several strains of diplostreptococcus agalactiae, propionibacterium acnes, staphylococcus aureus, and streptococcus serogroups a, b, and g were studied. all of these organisms have been reported to be associated with arthritic transudates in humans. metabolites were detected by this method from de ... | 1978 | 721944 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide--viii. | 1978 | 721660 | |
| immune prophylaxis of experimental cancer by corynebacterium parvum. | fractionated administration of c.p. i.v. in mice at risk from sarcomas after injection of 0.2 mg mca leads to a significant prolongation of the period of latency under certain circumstances. experimental groups which have received the immune stimulator for 6 weeks immediately after the cancerogenic factor show the best results. after tumour manifestation there is no perceptible preventive effect of c.p. | 1978 | 720440 |
| positive 67ga-citrate scans in patients receiving corynebacterium parvum. | gallium-67 citrate imaging for the staging of lymphomas was performed in three patients receiving corynebacterium parvum (c. parvum) immunotherapy. unexpected uptake at the site of c. parvum injections was identified and although the mechanism of localization is not determined by this study, similarities between c. parvum's known actions and the postulated mechanism of 67ga-citrate localization are compared. | 1978 | 719980 |
| destruction of regional lymph node metastases of rat mammary adenocarcinoma 13762a by treatment with corynebacterium parvum. | intratumoral administration of corynebacterium parvum to 13762a tumor-bearing rats on day 7 of tumor growth, followed by primary tumor excision on day 20, regularly cured about 40% of the animals and significantly prolonged survival in the remainder. rats treated by surgery alone on either day 7 or day 20 died with metastases to axillary lymph nodes and lungs. tumor was established in axillary lymph nodes by day 7. therefore, intratumoral injection of c. parvum on day 7 destroyed metastases alre ... | 1978 | 719637 |
| toxicity manifestations following intravenous corynebacterium parvum administration to patients with ovarian and cervical carcinoma. | manifestations of clinical toxicity were evaluated following 341 courses of intravenous corynebacterium parvum adjuvant immunotherapy in patients with ovarian and cervical carcinoma. most patients exhibited symptoms of minor toxicity, which decreased in intensity as subsequent courses of therapy were administered. temperature elevations to 38.5 degrees c. were the most objectively measured signs of toxicity but temperature elevations greater than 38.5 degrees c. occurred following only 20.5 per ... | 1978 | 717456 |
| pigment vs cholesterol cholelithiasis: bacteriology of gallbladder stone, bile, and tissue correlated with biliary lipid analysis. | 1978 | 717347 | |
| characterization of propionibacterium acnes isolated from biopsy specimens obtained from patients with sarcoidosis. | 1978 | 713132 | |
| bacteriological investigation on biopsy specimens from patients with sarcoidosis. | biopsy specimens, mostly lymph nodes, removed under aseptic conditions, were emulsified and the homogenate was inoculated in various media, which were incubated aerobically or anaerobically. only propionibacterium acnes was isolated in high incidence and the highest concentration of bacteria was 6.5 x 10(5) per g tissue: 28 and 31 out of 40 lymph nodes were positive on solid and on liquid media, respectively. p.acnes was also isolated from control non-sarcoidosis lymph nodes: 4 and 8 out of 14 w ... | 1978 | 713130 |
| lysozyme levels and macrophage content of tumor tissue in c3h mice bearing fibrosarcoma transplants treated by radiation and corynebacterium parvum. | 1978 | 711553 | |
| combined radiotherapy and corynebacterium parvum treatment of rat tumors with different immunogenicity. | 1978 | 711536 | |
| a preliminary study of intralesional, intralymph node, intravenous and intraperitoneal corynebacterium parvum treatments in patients with advanced cancer. | twenty-one patients with squamous cell carcinoma of oral cavity and/or cervical lymph node and four patients with soft tissue sarcomas were given intralesional (2-4 mg/m2) and intralymph node (2-4 mg/m2) c. parvum injections followed by 5 intravenous (2-4 mg/m2) c. parvum treatments and conventional therapies. seven patients with stage iii ovarian carcinomas were given intraperitoneal (2-4 mg/m2) c. parvum injections followed by conventional therapies. the local and systemic effects of the c. pa ... | 1978 | 709538 |
| bacteriologic examination of autologous blood. | 1978 | 705401 | |
| failure of preoperative c. parvum vaccine to modify secondary disease following excision of two non-immunogenic murine carcinomas. | sadler and castro (1976) reported that a single dose of c. parvum vaccine given i.p. or i.v. to mice 4 days before excision of subcutaneous transplants of lewis lung carcinoma significantly reduced the incidence of lung metastases in the operated mice. in similarly designed experiments, using 2 different carcinomas of spontaneous origin in our own inbred mouse colonies, we were unable to demonstrate any influence of c. parvum vaccine on the incidence or latent period of secondary disease in oper ... | 1978 | 698036 |
| immunoproliferative alterations in lymphoid tissues and liver in mice stimulated with corynebacterium parvum. | morphological alterations in the spleen, liver, lymph nodes, thymus, bone marrow and blood were studied in dba and balb/c mice treated with corynebacterium parvum. the spleen lymph nodes and liver increased in size and weight, whereas thymus showed decrease in weight compared to the control group. a marked, early proliferation of monocytes in the bone marrow preceded infiltrations by macrophages in lymph nodes, spleen and liver. these infiltrations were closely related to the vascular structures ... | 1978 | 696333 |
| preliminary observations on the use of corynebacterium parvum in patients with primary intracranial tumors: effect on intracranial pressure. | it has been observed that patients with metastatic brain lesions developed neurologic symptoms when given corynebacterium parvum. to obtain more information in patients with intracranial mass lesions, intracranial pressures (icp) were measured or observed in six patients undergoing c. parvum therapy. all patients except two (one previously shunted, one recently operated) demonstrated a profound increase in icp. it is presumed that either edema is formed within brain and tumor tissue (inasmuch as ... | 1978 | 692136 |
| in vitro activity of tiamulin (81.723 hfu), a new pleuromulin derivative, against clinically significant anaerobes. | the susceptibility of more than 40 strains of gram-negative and gram-positive anaerobes to tiamulin (sandoz 81.723 hfu), a new pleuromulin (pleuromutilin) derivative, was determined by broth dilution and agar dilution tests. the influences of density of the inoculum upon mics was studied by a specially designed pour plate-technique. bacteroides fragilis, b. vulgatus, b. splanchnicus, b. oralis, b. asaccharolyticus, b. melaninogenicus, fusobacterium fusiforme (f. nucleatum), sphaerophorus necroph ... | 1978 | 690009 |
| interferon production and lymphocyte stimulation in human leucocyte cultures stimulated by corynebacterium parvum. | killed c. parvum organisms stimulated a lymphoproliferative response in human peripheral leucocyte cultures of both adult and cord blood origin. they also induced high titres of interferon in cultures of adult leucocytes, but there was no correlation between the degree of lymphocyte stimulation and of interferon production. a considerable variability between donors was seen in both assays. the amount of interferon produced in c. parvum-stimulated cultures was considerably higher than that stimul ... | 1978 | 688696 |
| cytotoxic activity of human blood monocytes against cultured breast cancer cells. | cytotoxic activity of blood monocytes from 19 healthy individuals was examined in vitro against the cultured floating cells of human breast cancer origin. target tumor cells inoculated on monocyte cultures and maintained for 5 days were reduced in number, compared with the control cultues of tumor cells alone. increased cytotoxicity of the monocytes was noted after in vitro activation by heat-killed corynebacterium liquefaciens (propionibacterium acnes). c. liquefaciens of the same dose as used ... | 1978 | 680464 |
| rate of tumour inhibition by activated macrophages in vitro. | 1978 | 679868 | |
| comparison of the inhibition of tumor growth following local or systemic administration of corynebacterium parvum or other immunostimulating agents with or without cyclophosphamide. | 1978 | 679170 | |
| effect of corynebacterium parvum on the proliferative rate of granulocyte-macrophage progenitor cells and the toxicity of chemotherapy. | we have studied the interaction of corynebacterium parvum and a variety of cell cycle-specific and cell cycle-nonspecific chemotherapeutic agents on granulocyte-macrophage progenitor cells [colony-forming units culture (cfu-c)] in c57bl/6 mice. in vitro tritiated thymidine suicide studies showed an increased rate of proliferation of bone marrow cfu-c 24 hr after c. parvum injection. in vivo toxicity of cell cycle-specific agents but not of cell cycle-nonspecific agents for bone marrow cfu-c was ... | 1978 | 679169 |
| coagulation and fibrinolysis during the infusion of corynebacterium parvum in man. | 1978 | 678428 | |
| anaerobic flora of the normal human conjunctival sac. | specimens from the conjunctival sacs of 92 healthy eyes were cultured on two separate occasions to determine the presence or absence of a persistent anaerobic flora. aerobic bacteria and fungi were also studied for comparison. of the 184 eye cultures, 112 (60.9%) contained at least one microorganism. obligate anaerobes were recovered from 51.6% (95/184) of the cultures. propionibacterium acnes, the predominant anaerobe encountered, was present in 49.5% (91/184) of the eyes. aerobic and facultati ... | 1978 | 678185 |
| electrophoretic protein patterns and enzyme mobilities in anaerobic coryneforms. | the soluble protein patterns and electrophoretic mobilities of malate and succinate dehydrogenases and catalase have been examined in 25 strains of propionibacterium acnes, p. granulosum, and p. avidum. a distinctive protein pattern for each species was found, and it was possible also to distinguish the serotypes within p. acnes and p. avidum. strains of p. acnes, p. granulosum, and p. avidum could be differentiated by the mobilities of their malate dehydrogenases. catalase activity was detected ... | 1978 | 677876 |
| induction of interferon in mice injected with heat-killed corynebacterium anaerobium. | 1978 | 671815 | |
| effects of corynebacterium parvum and cortisone on the primary lewis tumour and its metastases. | the effects of corynebacterium parvum and cortisone acetate (ca) on the primary lewis lung carcinoma and its pulmonary metastases were investigated. c. parvum given iv either on the same day or 7 days after tumour inoculation, reduced primary tumour growth, while 2.5 mg ca (high-dose) given sc 4 and 11 days after tumour, alone or in combination with c. parvum, administered on day 0, reduced primary tumour growth to the same extent as c. pravum alone. high-dose ca given on days 2 and 6 had no eff ... | 1978 | 669856 |
| response of malignant melanoma to plasma exchange, surgical debulking, and corynebacterium parvum. | a 48 year old man with extensive cutaneous and subcutaneous metastatic malignant melanoma responded to treatment by repeated plasma exchanges, partial surgical debulking of tumor masses, and intravenous corynebacterium parvum. circulating immune complexes were measured by the serum c1q binding method. tumor regression coincided with serum c1q binding reduction to normal levels. clinical relapse was preceeded by recurrent elevation of serum c1q binding activity. | 1978 | 669835 |
| immunity to transplantable carcinogen-induced fibrosarcomas in b2/b2 chickens. iii. tumor growth inhibition by local delayed hypersensitivity reactions to unrelated antigens. | delayed hypersensitivity (dh) reaction to human ig, corynebacterium parvum or allogeneic cells at the site of tumor cell injection, suppressed the fibrosarcoma (scfs) growth in chickens. spleen cells of sc chickens sensitized to human ig or c. parvum suppressed scfs growth when adoptively transferred with tumor cells, but only when the sensitizing antigen was present locally. this suppression did not occur in irradiated recipients, scfs i cells injected into wattles of chickens immune to the tum ... | 1978 | 668800 |
| nephrotoxicity from cancer immunotherapy. | because systemic intravenous immunotherapy with corynebacterium parvum is an effective immunopotentiating and immunotherapeutic agent in animals, clinical studies of this agent have been undertaken. toxicities in man have been noted, but most are treated symptomatically. three patients with metastatic melanoma developed oliguria, edema, diffuse bilateral pulmonary infiltrates, azotemia, hypoalbuminemia and hypocomplementemia, while receiving intravenous c. parvum therapy. all had renal biopsies ... | 1978 | 666183 |
| prospective randomized evaluation of the role of limb-sparing surgery, radiation therapy, and adjuvant chemoimmunotherapy in the treatment of adult soft-tissue sarcomas. | 1978 | 663826 | |
| radiation-induced inhibition of splenocyte locomotion and its protection by c. parvum. | 1978 | 663069 | |
| effect of aerobic and anaerobic corynebacteria on reaginic antibody response in mice. | 1978 | 661628 | |
| induction of spleen cell growth and dna polymerase activity by corynebacterium parvum. | corynebacterium parvum induces rapid proliferation of spleen cells with concomitant rapid increases in dna synthesis as measured by [3h]thymidine uptake and increase in dna polymerase activity. cell number increased exponentially over 10 days. dna polymerase activity increased 8-fold after c. parvum stimulation. the rapidity of response indicated a population response to the stimulus, and the data are consistent with a direct stimulation of spleen cell proliferation by c. parvum. | 1978 | 647675 |
| monocyte function in patients with solid neoplasms during immunotherapy with corynebacterium parvum. | the present studies were performed in order to evaluate monocyte function in patients with solid neoplasms before and after administration of c. parvum. the results demonstrate that monocytes from cancer patients display increased numbers of c3 and fc receptor sites after administration of c. parvum. it is concluded that characterization of monocyte receptor activity may be helpful in monitoring the effects of immunotherapy in the immune system. | 1978 | 647625 |
| decreased hepatic drug demethylation in patients receiving chemo-immunotherapy. | the effect of immunotherapy and chemotherapy on hepatic n-demethylation of aminopyrine was studied by means of the aminopyrine breath test (abt) in 32 patients with cancer. the aminopyrine breath test (abt) was decreased in 3 of 11 patients (27.3%) receiving intradermal bcg (+/- dtic) at a dose of 3 x 10(7) viable organisms. one of 4 (25%) patients receiving intradermal bcg (+/- dtic) at 3 x 10(8) viable organisms per dose developed an altered abt. changes were not seen in patients receiving aer ... | 1978 | 647621 |
| corynebacterium parvum enhances colonic cancer in dimethylhydrazine-treated rats. | 1978 | 646934 | |
| effects of amputation and corynebacterium parvum on tumour metastases in mice. | the effects of operation (lower-limb amputation) on the growth of the lewis lung tumour and its metastases were studied. the role of c. parvum in counteracting these effects was investigated. anaesthesia alone or with amputation did not affect primary tumour growth. c. parvum depressed this growth. anaesthesia did not affect the number of pulmonary metastases, but amputation caused a significant increase. c. parvum inhibited metastases and completely counteracted the effects of operation on them ... | 1978 | 646927 |
| thymoindependent antigentic stimulation in nude mice: response to polyvinylpyrrolidone and adjuvant effects of corynebacterium parvum and lh1. | the humoral thymoindependent response to polyvinylpyrrolidone (pvp) measured by the farr test, was not different in athymic nude and phenotypically normal mice. in athymic and normal mice, this response was significantly increased by cornebacterium parvum administered at the time of immunization. a recently synthetized compound, lh1 (3alpha-n-[2 aminoethanol]-amino 5-alpha-pregnane-20-one) was, however, a better immunostimulant of the anti-pvp response in athymic mice. | 1978 | 640744 |
| phase i studies of c. parvum given intravenously: effects of dexamethasone on its biologic and toxic properties. | three biologic effects were clearly associated with c. parvum infusions: a) granulocytosis with lymphomonocytopenia, b) increase in responsiveness to phytohemmagglutinin and c) increase of specific antibodies to c. parvum antigens. addition of dexamethasone moderately altered the kinetics of leukocyte changes without affecting other properties. side effects after intravenous administration of c. parvum (2.5 mg/m2) consisted primarily of chills and fever which lasted for periods of 6-24 hours. s ... | 1978 | 638994 |
| endophthalmitis caused by propionibacterium acnes. | we treated a man who developed endopthalmitis six weeks after a seemingly minor injury. cultures were positive for propionibacterium acnes, an anerobic, gram-positive rod that is a normal inhabitant of the conjunctiva but is rarely a cause of endophthalmitis. the patient underwent vitrectomy and lensectomy with intravitreal injection of antibiotics followed by systemic cephalothin and prednisone. clinical and visual improvement was rapid. | 1978 | 638845 |
| studies with a spontaneous mouse tumor. i. growth in normal mice and response to corynebacterium parvum. | growth of isogeneic transplants of a spontaneous murine adenocarcinoma, which is virtually devoid of tumour-specific transplantation antigens, is inhibited by i.v. injection of c. parvum 3 days after tumour inoculation, or by mixing a small dose of c. parvum with the tumour inoculum. moreover, the therapeutic effect of cyclophosphamide, followed by i.v. or i.p. injection of c. parvum 5 days later, on established transplants of the same tumour is greater than that of cyclophosphamide alone. these ... | 1978 | 638014 |
| comparative studies of porphyrin production in propionibacterium acnes and propionibacterium granulosum. | porphyrin production by propionibacterium acnes and that by propionibacterium granulosum were compared. porphyrin synthesized by both organisms was identified as coproporphyrin iii on the bases of absorption and fluorescence spectra and behavior on paper chromatography and thin-layer chromatography. quantitative, rather than qualitative, differences in production were found between these organisms. in general, p. granulosum produced significantly greater amounts (p less than 0.001) of porphyrin ... | 1978 | 637914 |
| immunotherapy of cancer with corynebacterium parvum. | 1978 | 637374 | |
| modification of radiation responses of murine tumors by misonidazole (ro 07-0582), host immune capability, and corynebacterium parvum. | the hypoxic cell sensitizer misonidazole (ro 07-0582),1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol, significantly enhanced the local control of the weakly immunogenic c3h mouse mammary carcinoma mdah-mca-4 (8-mm diameter) by single doses of radiation. the dose modification factor (dmf) was 2.33 when the drug was given ip to inbred c3hf/bu mice in a dose of 1 mg/g body weight 30 minutes before irradiation of the tumor. the dmf in a highly immunogenic 3-methylcholanthrene-induced c3h fibrosarcoma ... | 1978 | 633396 |
| corynebacterium parvum-induced resistance to a methylcholanthrene fibrosarcoma. | 1978 | 627989 | |
| natural cell-mediated cytotoxicity in rats. ii. in vivo augmentation of nk-cell activity. | natural cell-mediated cytotoxicity in rats as well as in mice has been shown to vary consistently with age, with peak levels detectable at 5-10 weeks. the levels of cell-mediated cytotoxicity against tumor cells could be augmented in strains of inbred rats with either high or low levels of natural reactivity, by ip injection of a variety of agents, including c. parvum, lcmv, krv, and poly i:c. the specificity of the augmented cytotoxicity appeared to be the same as the specificity of natural kil ... | 1978 | 627428 |
| enhancement by corynebacterium parvum of the normal and tumor tissue response to hyperthermia. | the effect of corynebacterium parvum treatment on the response of tumor and normal tissue to hyperthermia (43.5 degrees) was studied. animals were c3hf/sed mice from our defined flora mouse colony. the time at hyperthermia that achieved control of one-half of methylcholanthrene-induced fibrosarcomas and the foot reaction were examined after treatment. c. parvum, if given 3 to 32 days before hyperthermia, enhanced the reaction to local hyperthermia of normal tissue. no enhancement was observed if ... | 1978 | 626985 |
| immunotherapy of an established rat mammary adenocarcinoma (13762a) with intratumor injection of corynebacterium parvum. | we studied the effects of intratumor injection of corynebacterium parvum vaccine on the survival of 13762a tumor-bearing rats. vaccine injection of established (7-day-old) tumors produced dose-related prolongation of survival and cured some animals. although 30 to 40% of the vaccine-injected primary tumors regressed, recurrences and continued growth of metastases ultimately killed one-fourth of the regressors. rats given 1500 microgram of c. parvum intratumorally at 7 days, with or without later ... | 1978 | 626972 |
| antitumor activity of purified cell walls from corynebacterium parvum. | cell walls (cw), containing peptidoglycan and carbohydrate, were prepared from corynebacterium parvum and tested for lymphoreticular stimulation and antitumor effects in cba-t6t6 mice. cw did not induce splenomegaly. peritoneal macrophages became cytostatic to rl leukemia cells in vitro after ip injection of cw or of peptidoglycan but not of carbohydrate; however, on a dry-weight basis the activity was low (less than 10%) compared with that of c. parvum. tumor outgrowth was significantly suppres ... | 1978 | 625069 |
| use of bacteriophage typing to distinguish propionibacterium acne types i and ii. | strains of serotypes i and ii of propionibacterium were compared for phage sensitivity. the two serotypes could be distinguished by using a typing set consisting of 16 bacteriophages at concentrations that demonstrated selective lysis of serotype i or ii bacterial strains. seven phage types were found; three were composed exclusively of serotype i, and four were exclusively composed of serotype ii organisms. generally, serotype i strains were more sensitive to phage lysis than were serotype ii s ... | 1978 | 624772 |
| treatment of malignant ascitic and pleural effusion with corynebacterium parvum. | six patients with malignant effusions, five from adenocarcinomas and one from a melanoma, were treated by intrapleural or intraperitoneal corynebacterium parvum. in each case there was a definite reduction in the effusions with a significant decrease in the number of malignant cells; in most cases the effusions stopped completely. although none of the patients lived for more than a year after treatment, they were undoubtedly more comfortable, as they no longer required frequent paracentesis. in ... | 1978 | 623981 |
| regional variations of cutaneous propionibacteria. | propionibacterium acnes, p. avidum, and p. granulosum were quantitatively measured in 50 young adults. the scalp, forehead, external auditory canal, alae nasi, anterior nares, groin, rectum, and antecubital and popliteal fossa were sampled. these represent various cutaneous microenvironments, differing in moisture, density of sweat, sebaceous glands, and extent of anaerobiosis. these studies show that the propionibacteria are ubiquitous on the skin, with p. acnes predominant in both prevalence a ... | 1978 | 623473 |
| heterologous immunity between piroplasms and malaria parasites: the simultaneous elimination of plasmodium vinckei and babesia microti from the blood of doubly infected mice. | mice which have recovered from infections with the avirulent piroplasm babesia microti are also resistant to challenge with the virulent malaria parasite plasmodium vinckei. in mice infected with p. vinckei before the peak of the b. microti infection the numbers of malaria parasites in the blood increase until that peak and are then eliminated at the same time as the piroplasms. in mice infected with p. vinckei at or after the peak there is no apparent multiplication and the malaria parasites be ... | 1978 | 622306 |
| [finding of anaerobic bacteria in blood cultures]. | out of the blood cultures sent to the bacteriology laboratory of hospital del niño dif, during the period of one year, in 1.4% of samples, isolation of anaerobic bacteria was obtained. isolation was more frequent in infants under one year of age, but specially in newborns. the species most frequently found were propionibacterium acnes, bacteroides melaninogenicus and clostridium subterminale. the presence of this finding in blood cultures of infants is noted, but there is no purpose to establish ... | 1978 | 619923 |
| [immunological and immunotherapeutical aspects of cancer (author's transl)]. | 1978 | 619481 | |
| immune responses during administration of adriamycin and corynebacterium parvum. | 1978 | 618689 | |
| influence of immunotherapeutic agents on the progression of spontaneously arising, metastasizing rat mammary adenocarcinomas of varying immunogenicities. | 1978 | 618584 | |
| correlation of antitumor chemoimmunotherapy with serum inhibition of tumor cell destruction. | the administration of cyclophosphamide and corynebacterium parvum in combination results in tumor growth inhibition greater than that resulting from the use of either agent alone. the precise mechanism(s) by which this chemoimmunotherapy combination results in a synergistic inhibiting effect is not known. the possibility was entertained that the tumor effect might be related to a greater decrease in serum-mediated interference with cellular cytotoxicity, i.e., "blocking" activity, by both agents ... | 1978 | 618581 |
| organ distribution of technetium-99m-labeled corynebacterium parvum in normal and tumor-bearing mice. | 1978 | 618580 | |
| [study of the tolerance of a submucous injection of coryné parvum in the dog bladder]. | 1977 | 617754 | |
| measurement of phagocytic activity of reticuloendothelial system (res) by intralipid: effect of c parvum treatment. | 1977 | 617547 | |
| the effect of intradermal administration of corynebacterium parvum on the immune response to hepatitis bs antigen. | the immunopotentiating effect of the intradermal administration of a course of four doses (0.25 ml) of a standard suspension of killed c. parvum (2 mg/ml) was studied in a group of 10 asymptomatic chronic hepatitis b surface antigen (hbsag) carriers, as well as in 11 persons with antibodies to hbsag (anti-hbs) and six without hbsag or anti-hbs. hbsag, anti-hbs, and leukocyte migration inhibition (lmi) studies were performed in pre- and post-inoculation blood samples. c. parvum produced a substan ... | 1977 | 609027 |
| proposals for quality control methods of bacterial vaccines for immunostimulation. i. general considerations. | control methods for this type of vaccines include tests on identity, absence of contaminating microorganisms and safety which are required for any vaccine. in addition, for the control of vaccines for immunostimulation in cancer therapy some special methods for safety and potency testing are required. some assays are proposed, such as stimulation of lymphocytes in vivo and in vitro, stimulation of macrophages (listeria clearance) in mice and the prophylactic and therapeutic tumor model in mice. ... | 1977 | 608552 |
| c. parvum skin testing antigen: study on guinea pig model. | a skin-testing antigen produced from c. parvum has been developed for exploring cell-mediated immunity and specially c. parvum specific cell-mediated immunity by delayed cutaneous hypersensitivity (dch) reaction. the dch antigen and the techniques of intradermal injection and multiple puncture are described. dch reactions are carried out in c. parvum specifically sensitized guinea pigs: sensitization procedure and adjuvant (ifa and cfa) effects are reported. measures of dch reactions for differe ... | 1977 | 608551 |
| mouse tumour tests for quality control of c. parvum preparations. | description of two mouse tumor tests selected to control the quality of c. parvum pilot productions: transplanted ehrlich's ascitic tumor in inbred swiss mice and transplanted yc8 ascitic tumor in isogenic balb/c mice. the results obtained during three years of control are analyzed, particularly accuracy, long range adequacy and reproducibility of tumor challenges and c, parvum stimulations. the effects of some parameters of the tumor tests, e.g. dose-responses, treatment schedules, tumor-host r ... | 1977 | 608550 |
| intra-tumour c. parvum therapy in gastric carcinoma; a pilot study. | in a preliminary and toxicological study, eight patients with carcinoma of the stomach were treated by corynebacterium parvum immunotherapy prior to surgical excision. killed c. parvum suspension was injected at multiple sites directly into the tumour mass with the aid of fibre-optic gastroscope at doses of 1.5 mg, 4 mg or 8 mg. each patient received two injections of the same dose with an interval of 14 days. the second injections were made 14 to 18 days prior to surgery. no chemotherapy was ad ... | 1977 | 608548 |
| a survey of patients' reactions to intravenous corynebacterium parvum therapy. | a survey was made of patients' reactions to high dose (21 mg) corynebacterium parvum therapy given intravenously over four hours. the patients completed a pro forma. rigors were the commonest side effect complained of being present in nearly all patients (24/25) and being very severe in one-third (10/25). other problems were nausea (15/25), vomiting (17/25), bone pain (12/25) and headaches (12/25). one-third also usffered with other less common side effects. overall, patients felt the side effec ... | 1977 | 608547 |
| toxic and immunologic side effects of daily c. parvum-infusion in treatment-resistant cancer patients. | daily increasing intravenous doses of corynebacterium parvum (c.p.) up to 5 mg/m2 i.v. x 10-14 days were given to 6 patients with widespread metastatic neoplastic diseases resistant to radio- and chemotherapy. the immunotherapy treatment-cycles were evaluated for toxic and immunologic side effects and also for possible clinical benefit to the patients. immunotherapy with i.v.-c.p. was moderately well tolerated. subjective discomfort for the patients (headache, chills, nausea) was not better tole ... | 1977 | 608546 |
| experience with the quality control testing of c. parvum suspension for clinical trial. | the control of c. parvum suspension presents special problems. the intended application of this preparation is in a therapeutic area where clinicians are accustomed to using defined chemical entities the biological activity of which are usually predictable according to weight of active principle administered, the route and number of doses. but the essential character of c. parvum is that of a vaccine in which the character of the active principle or principles is not clearly identified and can v ... | 1977 | 608544 |
| first impressions of i.v. c. parvum in patients with solid tumours. | 6 patients with solid tumours (4 malignant melanomas, one fibrosarcoma, one osteogenic sarcoma) received i.v. c. parvum alone or in combination therapy (radiotherapy, levamisole and/or vitamin a). the single doses of c. parvum ranged from 5.0-7.5 mg/m2; no. of doses ranged from 1-8; interval between doses ranged from 2-140 days. 2 patients with malignant melanoma had no measurable disease, one of them (stage i) still has no evidence of disease. the patient with fibrosarcoma appeared to have a mi ... | 1977 | 608543 |
| further studies on the serological effects of c. parvum immunotherapy in cancer patients. | previous serological studies undertaken in our laboratory have shown that the repeated administration of small doses of c. parvum to a small group of cancer patients resulted in a consistant increase in the levels of igg (especially the igg2b subclass), the development of antibodies to c. parvum and the transient appearance of 'rheumatoid factor like' substances in the serum (br. j. cancer, 32, 310, 1975). in the present paper we report the results of similar studies in small numbers of (a) inop ... | 1977 | 608542 |
| the effect of intravenous infusion of corynebacterium parvum on an immune profile of women with breast cancer. | an immunological profile has been measured in 21 patients with advanced breast cancer who were treated with c. parvum (wellcome strain cn6134). thirteen patients received a single i.v. dose of 15 mg of c. parvum and 8 received 4 mg i.v. on 5 successive days. the "profile" was recorded before and 7-10 days after treatment and included measurement of total white count, absolute lymphocyte and monocyte counts, pha response, b and t cell percentages. dncb and mantoux skin tests, immunoglobulin class ... | 1977 | 608540 |
| in vitro and in vivo effects of corynebacterium parvum on lymphocyte transformation. | using a range of doses the effect of c. parvum on the in vitro response of lymphocytes to pha was studied. c. parvum was not found to be mitogenic itself when added to unfractioned lymphocyte cultures from normal donors and patients with breast cancer, nor did it effect the response to pha in these cultures except at the highest dose (20 microgram/100,000 cells) when it was inhibitory. 21 patients with breast cancer treated with c. parvum were assessed by their in vitro response to pha prior to, ... | 1977 | 608539 |
| the effect of corynebacterium parvum on human effector cells in peripheral blood. | 1977 | 608538 |