Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| functional analysis and molecular characterization of spontaneously outgrown human lymphoblastoid cell lines. | in vitro, the infection of human b-cells with the lymphotropic gammaherpesvirus epstein-barr virus (ebv) induces formation of permanently growing lymphoblastoid cell lines (lcl). in a spontaneously outgrown lcl (cell line csiii), we detected nucleotide sequence variations of the ebv nuclear antigen 1 (ebna1) rna that was different from the reference sequence of ebna1 in the prototypic ebv strain b95-8. in the present study, we molecularly and functionally characterized this virus isolate in comp ... | 2014 | 25037273 |
| investigation of epstein-barr virus and parvovirus b19 dna in allogeneic stem cell transplant patients. | we aimed to investigate posttransplant epstein-barr virus (ebv) and parvovirus b19 dna in allogeneic stem cell transplant patients between 2009 and 2010. | 2014 | 25035673 |
| epstein-barr virus (ebv)-encoded dutpase and chronic restraint induce impaired learning and memory and sickness responses. | most adult humans have been infected with epstein-barr virus (ebv) and carry the latent virus. the ebv genome codes for several proteins that form an early antigen complex important for viral replication; one of these proteins is deoxyuridine triphosphate nucleotidohydrolase (dutpase). the ebv-encoded dutpase can induce sickness responses in mice. because stress can increase latent virus reactivation, we hypothesized that chronic restraint would exacerbate sickness behaviors elicited by ebv-enco ... | 2014 | 25034413 |
| gianotti-crosti syndrome associated with ebstein-barr virus and parvovirus b-19 coinfection in a male adult: case report and review of the literature. | gianotti-crosti syndrome (gcs) is a self-limiting, mostly childhood-appearing, cutaneous eruption with characteristic symmetric areal distribution. the original cases, described by gianotti in 1955, were associated with hepatitis b virus infection, but other viral and bacterial infections, as well as immunizations, have been implied in etiology of this condition. adult cases are rare and have been reported almost exclusively in women. we present the case of a 20-year-old caucasian man who had ty ... | 2016 | 25034095 |
| critical review of topical management of oral hairy leukoplakia. | oral hairy leukoplakia (ohl) is a disease associated with epstein-barr virus and human immunodeficiency virus infections. ohl is usually an asymptomatic lesion, but in some cases treatment is recommended to reestablish the normal characteristics of the tongue, to eliminate pathogenic microorganisms, to improve patient comfort and for cosmetic reasons. proposed treatments for this condition include surgery, systemic antiviral treatment and topical management. topical treatment is an inexpensive a ... | 2014 | 25032199 |
| concurrent alterations of rage, reck, and mmp9 protein expression are relevant to epstein-barr virus infection, metastasis, and survival in nasopharyngeal carcinoma. | this study aimed to concurrently investigate the expressions of receptor for advanced glycation end products (rage), reversion inducing cysteine-rich protein with kazal motifs (reck) and matrix metalloproteinase 9 (mmp9) in nasopharyngeal carcinoma (npc) and their correlations with clinicopathological properties. using immunohistochemistry, we found that reck expression was downregulated in npc tissues compared with chronic nasopharyngitis (cnt) tissues, while rage and mmp9 expressions were upre ... | 2014 | 25031745 |
| epstein-barr virus ebna1 protein regulates viral latency through effects on let-7 microrna and dicer. | the ebna1 protein of epstein-barr virus (ebv) plays multiple roles in ebv latent infection, including altering cellular pathways relevant for cancer. here we used microrna (mirna) cloning coupled with high-throughput sequencing to identify the effects of ebna1 on cellular mirnas in two nasopharyngeal carcinoma cell lines. ebna1 affected a small percentage of cellular mirnas in both cell lines, in particular, upregulating multiple let-7 family mirnas, including let-7a. the effects of ebna1 on let ... | 2014 | 25031339 |
| prevalence of targetable oncogenic mutations and genomic alterations in epstein-barr virus-associated diffuse large b-cell lymphoma of the elderly. | epstein-barr virus (ebv)-associated diffuse large b-cell lymphoma (dlbcl) of the elderly constitutes a provisional clinicopathological entity in the current world health organization (who) classification and its genomic features remain sparsely characterized. we investigated a cohort of 26 cases of untreated de novo ebv-positive dlbcl of the elderly by high-resolution array-based comparative genomic profiling and fluorescence in situ hybridization (fish). moreover, we screened for activating mut ... | 2015 | 25030036 |
| primary γδ t cell lymphoma of the lung: report of a case with features suggesting derivation from intraepithelial γδ t lymphocytes. | t cell lymphoma of γδ t cell origin is a rare disease that mainly involves extranodal sites and shows aggressive clinical behavior. here, we report a case of primary γδ t cell lymphoma of the lungs with epitheliotropism in the respiratory epithelium, a feature somewhat reminiscent of what is observed in enteropathy-associated t cell lymphoma. a 63-year-old man presented with chest pain and dyspnea on exertion, weight loss, and general weakness. on a positron emission tomography (pet) scan, multi ... | 2014 | 25027578 |
| clinico-pathological characteristics of different types of immunodeficiency-associated smooth muscle tumours. | rare epstein-barr virus (ebv)+ smooth muscle tumours (smt) manifest typically under immunosuppression. three major subtypes are known: human immunodeficiency virus-associated (hiv-smt), after transplantation (ptsmt) or associated with congenital immunodeficiency syndromes (ci-smt). so far, there are no analyses which compare the clinico-pathological characteristics of all three subtypes. case reports and case series on these three tumour types were collected (1990-2012). meta-data analysis was p ... | 2014 | 25027306 |
| myoclonus as the main presentation of epstein-barr virus encephalitis. | 2015 | 25027162 | |
| [differential diagnosis of rheumatic diseases and blood cancers involving the nasal cavity and accessory sinuses]. | to provide the clinical, laboratory, radiological, morphological, and immunomorphological signs that permit the differential diagnosis to be made in patients with involvement of the nasal cavity and accessory sinuses (ncas). | 2014 | 25026804 |
| cytotoxic t-cell and nk-cell lymphomas: current questions and controversies. | the cytotoxic t-cell and natural killer (nk)-cell lymphomas and related disorders are important but relatively rare lymphoid neoplasms that frequently are a challenge for practicing pathologists. this selective review, based on a meeting of the international lymphoma study group, briefly reviews t-cell and nk-cell development and addresses questions related to the importance of precise cell lineage (αβ-type t cell, γδ t cell, or nk cell), the implications of epstein-barr virus infection, the sig ... | 2014 | 25025449 |
| combined linkage and association studies show that hla class ii variants control levels of antibodies against epstein-barr virus antigens. | over 95% of the adult population worldwide is infected with epstein-barr virus (ebv). ebv infection is associated with the development of several cancers, including hodgkin lymphoma (hl). elevated levels of anti-ebv antibodies have been associated with increased risk of hl. there is growing evidence that genetic factors control the levels of antibodies against ebv antigens. here, we conducted linkage and association studies to search for genetic factors influencing either anti-viral capsid antig ... | 2014 | 25025336 |
| lymphomatoid granulomatosis associated with azathioprine therapy in crohn disease. | lymphomatoid granulomatosis (lyg) is a rare epstein-barr virus-associated lymphoproliferative disorder. it most often occurs in patients with immunodeficiency and the clinical course ranges from indolent behavior to that of an aggressive malignancy. pulmonary, central nervous system and dermatological manifestations are most common. to our knowledge this is the first reported case of lyg related to azathioprine therapy in crohn disease. | 2014 | 25022612 |
| update on infections and vaccinations in systemic lupus erythematosus and sjögren's syndrome. | to provide an update on infections in systemic lupus erythematosus (sle) and sjögren's syndrome, particularly addressing their role as triggers of autoimmunity, their impact on mortality, the main microorganisms, the approaches to differential diagnosis with disease flares and recommendations for vaccination. | 2014 | 25022358 |
| synchronous tuberculosis, epstein-barr virus-associated lymphoproliferative disorder and cytomegalovirus infection in an allogeneic transplant recipient: a case report. | allogeneic stem cell transplant recipients are prone to infections by various organisms. tuberculosis (tb) represents a rare infectious complication, especially in countries non-endemic for tb. | 2014 | 25019038 |
| cutaneous intravascular natural killer-cell lymphoma: a case report and review of the literature. | to our knowledge, since 2003, there have been 11 reported cases of intravascular natural killer (nk)-cell lymphoma (ivnkl). herein we describe the 12th case. | 2014 | 25015867 |
| nervous system viral infections in immunocompromised hosts. | 2014 | 25015512 | |
| epstein-barr virus infections of the nervous system. | 2014 | 25015491 | |
| neuropathology of viral infections. | 2014 | 25015486 | |
| expression of cyclin-dependent kinase inhibitor 2a 16, tumour protein 53 and epidermal growth factor receptor in salivary gland carcinomas is not associated with oncogenic virus infection. | it is known that human papillomavirus (hpv) infection can cause squamous cell neoplasms at several sites, such as cervix uteri carcinoma and oral squamous carcinoma. there is little information on the expression of hpv and its predictive markers in tumours of the major and minor salivary glands of the head and neck. we therefore assessed oral salivary gland neoplasms to identify associations between hpv and infection-related epidermal growth factor receptor (egfr), cyclin-dependent kinase inhibi ... | 2015 | 25012870 |
| establishment and characterization of a rare atypical chronic myeloid leukemia cell line nt-1. | human leukemia cell lines are of great value in leukemia research. in this study, we established and described the biological characteristics of a rare atypical chronic myeloid (acml) leukemia cell line (nt-1). mononuclear cells were isolated from the bone marrow of a patient with atypical chronic myeloid leukemia (ph(-)/bcr(-)/abl(-)), and were passaged by liquid culture. cells were maintained without any cytokines for over 1 year, and named nt-1. this cell line was extensively characterized us ... | 2014 | 25012564 |
| low-dose otelixizumab anti-cd3 monoclonal antibody defend-1 study: results of the randomized phase iii study in recent-onset human type 1 diabetes. | previous studies demonstrated that the anti-cd3 monoclonal antibody otelixizumab, administered at a total dose of 48-64 mg, can slow the loss of c-peptide in recent-onset type 1 diabetes patients, with frequent reactivation of epstein barr virus (ebv). the defend-1 (durable response therapy evaluation for early or new-onset type 1 diabetes) trial was designed to test whether a lower dose of otelixizumab could preserve c-peptide secretion in new-onset type 1 diabetes patients. | 2014 | 25011949 |
| modelling the structure of full-length epstein-barr virus nuclear antigen 1. | epstein-barr virus is a clinically important human virus associated with several cancers and is the etiologic agent of infectious mononucleosis. the viral nuclear antigen-1 (ebna1) is central to the replication and propagation of the viral genome and likely contributes to tumourigenesis. we have compared ebna1 homologues from other primate lymphocryptoviruses and found that the central glycine/alanine repeat (gar) domain as well as predicted cellular protein (usp7 and ck2) binding sites are pres ... | 2014 | 25011696 |
| long-term complete remission of multiple extranodal natural killer/t-cell-type posttransplant lymphoproliferative disorder after surgical resection: a case report. | posttransplant lymphoproliferative disorder (ptld) is a life-threatening complication of organ transplantation that results from immunosuppression therapy. most cases of ptld derive from the b-cell lineage. t-cell ptld, particularly natural killer (nk)/t-cell ptld, is quite rare; only a few cases have been described. | 2014 | 25011572 |
| association of epstein-barr virus and passive smoking with the risk of breast cancer among chinese women. | reactivation of epstein-barr virus (ebv), as indexed by the higher immunoglobulin a (iga) antibody titers, was reported to be associated with an increased risk of breast cancer. passive smoking plays a role in host immune responses and may modify the association of ebv with breast cancer. we carried out a case-control study using data from 349 incident breast cancer cases and 500 age-matched controls in the guangzhou breast cancer study to investigate the interactions of ebv antibodies and passi ... | 2014 | 25010836 |
| felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats. | felis catus gammaherpesvirus 1 (fcaghv1), recently discovered in the usa, was detected in domestic cats in australia (11.4%, 95% confidence interval 5.9-19.1, n=110) and singapore (9.6%, 95% confidence interval 5.9-14.6, n=176) using qpcr. fcaghv1 qpcr positive cats were 2.8 times more likely to be sick than healthy. risk factors for fcaghv1 detection included being male, increasing age and coinfection with pathogenic retroviruses, feline immunodeficiency virus (fiv) or feline leukaemia virus. f ... | 2014 | 25010275 |
| epstein-barr virus-positive polymorphous lymphoplasmacytic infiltrate of the lacrimal glands in a patient with acute lymphoblastic leukemia. | 2014 | 25010171 | |
| vitamin d levels and monospot tests in military personnel with acute pharyngitis: a retrospective chart review. | some recent studies have proposed an important role for vitamin d in reducing the risk of infection by assisting in the suppression of viruses and by controlling the inflammatory response. a low vitamin d state may have a detrimental effect on the immune system's ability to produce activated cd8+ t cells, and it may increase the inflammatory reaction to epstein barr virus. the aim of this chart review was to see if serum 25 oh vitamin d3 levels in service members with acute pharyngitis were lowe ... | 2014 | 25009977 |
| significance of epstein-barr virus (hhv-4) and cmv (hhv-5) infection among subtype-c human immunodeficiency virus-infected individuals. | opportunistic viral infections are one of the major causes of morbidity and mortality in hiv infection and their molecular detection in the whole blood could be a useful diagnostic tool. | 2014 | 25008818 |
| ebv-positive mucocutaneous ulcer in organ transplant recipients: a localized indolent posttransplant lymphoproliferative disorder. | epstein-barr virus (ebv)-positive mucocutaneous ulcer (ebv mcu) is a b-cell lymphoproliferative disorder occurring in elderly or iatrogenic immunocompromised patients. it has not been reported in solid organ transplant recipients. we observed 7 patients with ebv mcu in a cohort of 70 transplant recipients with ebv posttransplant lymphoproliferative disorder (ptld). transplants included: 5 renal, 1 heart, and 1 lung. median patient age was 61; 5 were male. ebv mcu was observed in oral mucosa in 4 ... | 2014 | 25007145 |
| epstein-barr virus in oral mucosa from human immunodeficiency virus positive patients. | the detection rate of epstein-barr virus (ebv) is higher in people living with human immunodeficiency virus (hiv). in an attempt to contribute to our epidemiological understanding of this coinfection and to investigate the activity of ebv in normal oral mucosa, we performed a cross-sectional study with hiv-positive patients. | 2016 | 25004273 |
| design and development of antivirals and intervention strategies against human herpesviruses using high-throughput approach. | although a number of antiviral agents are licensed for treatment of some human herpesvirus (hhv) infections, effective antiviral therapy is not available for all hhvs. additional complications are associated with approved drugs, such as toxicity and side effects, and rise in drug-resistant strains is a driving force for new drug development. success in hhv vaccine development is limited with only vaccines against varicella-zoster virus currently in use in the clinic. in vitro, in vivo and in sil ... | 2014 | 25003658 |
| malignancies associated with epstein-barr virus: pathobiology, clinical features, and evolving treatments. | epstein-barr virus (ebv) is associated with a wide variety of b-cell-derived lymphoid neoplasms, including burkitt lymphoma, lymphomas arising in immunocompromised patients (post-transplant and hiv-associated lymphomas), and hodgkin lymphoma. in addition, ebv has been linked to some t-cell lymphomas (angioimmunoblastic t-cell lymphoma, extranodal nasal-type natural killer/t-cell lymphoma, and other rare histotypes), nasopharyngeal cancer, and a subset of gastric cancers. advances in our understa ... | 2014 | 25003566 |
| a case of atypical hemolytic uremic syndrome. | a 9-year-old boy presented with fever not responding to antibiotic therapy and elevated blood urea and serum creatinine levels. the patient developed microangiopathic hemolytic anemia and thrombocytopenia during the hospital stay. kidney biopsy confirmed the diagnosis of atypical hemolytic uremic syndrome (hus). the patient had sufficient urine output, normal blood pressure, and no evidence of peripheral edema during the whole course of his disease. serum levels of anti-epstein-barr virus immuno ... | 2014 | 25001143 |
| stochastic simulation algorithm for gene regulatory networks with multiple binding sites. | promoters with multiple binding sites present a regulatory mechanism of several natural biological systems. it has been shown that such systems reflect a higher stability in comparison to the systems with small numbers of binding sites. regulatory mechanisms with multiple binding sites are therefore used more frequently in artificially designed biological systems in recent years. while the number of possible promoter states increases exponentially with the number of binding sites, it is extremel ... | 2015 | 25000485 |
| dendritic cells during epstein barr virus infection. | epstein barr virus (ebv) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. this γ-herpes virus infects primarily human b and epithelial cells, but it has been reported to be sensed by dendritic cells (dcs) during primary infection. these activated dcs are thought to contribute to innate restriction of ebv infection and initiate ebv-specific adaptive immune responses via cross-priming. the respective evidence and their po ... | 2014 | 24999343 |
| decreased il-35 levels in patients with immune thrombocytopenia. | il-35 is a novel heterodimeric anti-inflammatory cytokine consisting of epstein-barr virus-induced gene 3 (ebi3) and the p35 subunit of il-12. il-35 has been shown to possess the potency of inhibiting the cd4+ effector t cells and alleviating autoimmune diseases. in the study we investigated the levels of il-35 as well as its prospective role in immune thrombocytopenia (itp).elisa was adopted to measure plasma il-35, tgf-β and il-10 levels. the mrna expression levels of p35 and ebi3 in periphera ... | 2014 | 24994465 |
| epstein-barr virus (hhv-4) inoculation to rabbits by intranasal and oral routes results in subacute and/or persistent infection dissimilar to human disease. | we report the infection of new zealand white rabbits with epstein-barr virus (ebv). | 2014 | 24993954 |
| human herpes viruses are associated with classic fever of unknown origin (fuo) in beijing patients. | few reports have examined the viral aetiology of fever of unknown origin (fuo). | 2014 | 24991930 |
| comprehensive high-throughput rna sequencing analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with hela cell genomes. | in an attempt to explore infectious agents associated with nasopharyngeal carcinomas (npcs), we employed our high-throughput rna sequencing (rna-seq) analysis pipeline, rna compass, to investigate the presence of ectopic organisms within a number of npc cell lines commonly used by npc and epstein-barr virus (ebv) researchers. sequencing data sets from both cne1 and hone1 were found to contain reads for human papillomavirus 18 (hpv-18). subsequent real-time reverse transcription-pcr (rt-pcr) anal ... | 2014 | 24991015 |
| genomic diversity of epstein-barr virus genomes isolated from primary nasopharyngeal carcinoma biopsy samples. | undifferentiated nasopharyngeal carcinoma (npc) has a 100% association with epstein-barr virus (ebv). however, only three ebv genomes isolated from npc patients have been sequenced to date, and the role of ebv genomic variations in the pathogenesis of npc is unclear. we sought to obtain the sequences of ebv genomes in multiple npc biopsy specimens in the same geographic location in order to reveal their sequence diversity. three published ebv (b95-8, c666-1, and hknpc1) genomes were first resequ ... | 2014 | 24991008 |
| [epstein-barr virus infection with severe consequences. ebv, haemophagocytic lymphohistiocytosis and hodgkin lymphoma with down syndrome]. | over 90% of the population is infected with the epstein-barr virus (ebv). following primary infection, the virus remains latent in b-lymphocytes. in isolated cases, especially in immunocompromised patients, the epstein-barr virus can result in a chronic active infection (caebv). | 2014 | 24988166 |
| viruses and human cancers: a long road of discovery of molecular paradigms. | about a fifth of all human cancers worldwide are caused by infectious agents. in 12% of cancers, seven different viruses have been causally linked to human oncogenesis: epstein-barr virus, hepatitis b virus, human papillomavirus, human t-cell lymphotropic virus, hepatitis c virus, kaposi's sarcoma herpesvirus, and merkel cell polyomavirus. here, we review the many molecular mechanisms of oncogenesis that have been discovered over the decades of study of these viruses. we discuss how viruses can ... | 2014 | 24982317 |
| prevalence and titre of antibodies to cytomegalovirus and epstein-barr virus in patients with autism spectrum disorder. | the etiology of autism spectrum disorders (asd) is currently unknown. few studies have explored the role of cytomegalovirus (cmv) and epstein barr virus (ebv) as potential etiological factors of asd. the aim of the present study was to evaluate the seropositivity rate and antibody titre to cmv and ebv in children with asd compared to same-aged healthy controls. | 2014 | 24982232 |
| features of epstein-barr virus reactivation after allogeneic hematopoietic cell transplantation in korean children living in an area of high seroprevalence against epstein-barr virus. | the present study was conducted to investigate epstein-barr virus (ebv) reactivation after hematopoietic cell transplantation (hct) in korean children living in an area of a high seroprevalence against ebv and to determine the impact of recipient age on ebv reactivation. medical records of 248 children and adolescents who had received allogeneic hct were retrospectively reviewed. the trends of ebv reactivation and post-transplant lymphoproliferative disorders (ptlds) were evaluated and compared ... | 2014 | 24981711 |
| [lymphomatoid granulomatosis - the past and present]. | lymphomatoid granulomatosis (lyg) is a rare multisystemic angiocentric and angiodestructive b lymphoproliferative disease that was first described by liebow in 1972. disease was then in the "gray zone" between vasculitis and lymphoproliferative disease. lyg is currently categorized as a primary b lymphoproliferative disease associated with epstein-barr (eb) virus according to the world health organization (who) classification of tumours. epidemiology, clinical course and treatment: lymphomatoid ... | 2014 | 24981698 |
| identification and characterisation of the il-27 p28 subunits in fish: cloning and comparative expression analysis of two p28 paralogues in atlantic salmon salmo salar. | interleukin (il)-27 is an il-6/il-12 family member with pro-inflammatory and anti-inflammatory properties. it is a heterodimeric cytokine composed of an α-chain p28 and a β-chain ebi3 (epstein-barr virus induce gene 3). the p28 subunit can also be secreted as a monomer and function as il-30 that acts as an inhibitor of il-27 signalling. at present, the p28 gene has only been described in mammals. thus, for the first time outwith mammals, we have identified seven p28 molecules in six divergent te ... | 2014 | 24981291 |
| calcineurin inhibitor-free graft-versus-host disease prophylaxis with sirolimus and mycophenolate mofetil in a second allogeneic stem cell transplantation for engraftment failure and rituximab-refractory epstein-barr virus-induced posttransplant lymphoproliferative disease. | posttransplant lymphoproliferative disease (ptld) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation. we describe here the case of a boy with history of induction failure of a t-cell acute lymphoblastic leukemia, who presented a life-threatening situation of nonengraftment and rituximab-refractory ptld after the first hematopoietic stem cell transplantation. we decided to use an unusual strategy of combining a nonmyeloablative conditioning (fludarabine an ... | 2014 | 24977404 |
| human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17a. | although it is widely believed that interleukin (il)-27 is anti-inflammatory, its role in controlling human immune responses is not fully established. in particular, its interactions with t helper type 17 (th)17 cytokines are unclear. our aims were to establish the relationships between il-27 and proinflammatory cytokines, including il-17a, in human sera and cultures of peripheral blood mononuclear cells. plasma il-27 levels in 879 healthy humans from 163 families varied widely, but with relativ ... | 2014 | 24975574 |
| [herpes simplex virus type 2 fulminant hepatitis after umbilical cord blood transplantation for acute myeloid leukemia]. | this report describes a 41-year-old patient, who developed herpes simplex virus type 2 (hsv-2)-hepatitis after umbilical cord blood transplantation (cbt). the patient had received allogeneic bone marrow transplantation from an unrelated donor for acute myeloid leukemia (aml) not in remission. aml relapsed 18 months after the first transplantation, and cbt was performed. aml relapsed again 5 months later and the patient was given chemotherapy. although there was no active chronic graft-versus-hos ... | 2014 | 24975337 |
| increased t-cell responses to epstein-barr virus with high viral load in patients with epstein-barr virus-positive diffuse large b-cell lymphoma. | the immunological status of patients with epstein-barr virus-positive diffuse large b-cell lymphoma (ebv+ dlbcl) without obvious immunodeficiency has not been elucidated. a multicenter prospective study was conducted to assess pretreatment t-cell responses to ebv, ebv-dna load and anti-ebv antibody in these patients. the proliferative and interferon (ifn)-γ-producing capacity of t-cells in response to autologous b-lymphoblastoid cell lines was determined using carboxyfluorescein diacetate succin ... | 2015 | 24975317 |
| clinical outcome of epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly in the rituximab era. | diffuse large b-cell lymphoma (dlbcl) is the most common subtype of malignant lymphoma. the incidence of epstein-barr virus (ebv)-positive dlbcl in asian and latin american countries ranges from 8 to 10%. the prognosis of patients with ebv-positive dlbcl is controversial. to compare the clinical outcome of ebv-positive and ebv-negative patients with dlbcl in the rituximab era, we analyzed 239 patients with de novo dlbcl diagnosed between january 2007 and december 2011. the presence of ebv in lym ... | 2014 | 24974976 |
| unexpected outbreak of epstein-barr virus post-transplantation lymphoproliferative disorder after hematopoietic stem cell transplantation conditioning with thymoglobulin. | 2014 | 24972250 | |
| genital ulcers: it is not always simplex …. | patients with vulval aphthae, also termed lipschütz ulcers, often present to genitourinary medicine clinics. typically, these ulcers present as acute, painful, vulval ulcers in young women and adolescents. the aetiology is unknown, and often these ulcers are accompanied by flu-like symptoms. previous case reports have linked such lesions to acute viral infections such as epstein-barr virus, cytomegalovirus and influenza a. we report the first case of influenza b virus and adenovirus infections a ... | 2015 | 24970475 |
| oxysterols and their cellular effectors. | oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol biosynthesis, with a spectrum of biologic activities. several oxysterols have cytotoxic and pro-apoptotic activities, the ability to interfere with the lateral domain organization, and packing of membrane lipids. these properties may account for their suggested roles in the pathology of diseases such as atherosclerosis, age-onset macular degeneration and alzheimer's disease. oxysterols also have the capacity ... | 2012 | 24970128 |
| aberrant satb1 expression is associated with epstein-barr virus infection, metastasis and survival in human nasopharyngeal cells and endemic nasopharyngeal carcinoma. | special at-rich sequence-binding protein 1 (satb1) has been identified as a key factor in the progression of some cancers, functioning as a global genome organizer and chromatin regulator. we examined the levels of satb1 mrna expression in npc cell lines 5-8f (high metastasis) and 6-10b (low metastasis) and immortalized human nasopharyngeal epithelial cells np69-sv40t by quantitative real-time pcr. we also examined the protein expression levels of satb1 in 72 cases of nasopharyngeal carcinoma (n ... | 2014 | 24966956 |
| spectrum of epstein-barr virus-associated t-cell lymphoproliferative disorder in adolescents and young adults in taiwan. | epstein-barr virus (ebv) is a herpesvirus usually infecting b-cells but may occasionally infect t- or natural killer (nk)-cells. ebv-associated t- or nk-cell lymphoproliferations represent a continuous spectrum of diseases ranging from asymptomatic infection, infectious mononucleosis (im), to clonal and malignant lymphoproliferations including systemic ebv-positive t/nk-cell lymphoproliferative disease (ebv-t/nk-lpd) of childhood and hydroa-vacciniforme-like lymphoma of the skin. the clonal dise ... | 2014 | 24966953 |
| clinicopathologic characteristics of inflammatory pseudotumor-like follicular dendritic cell sarcoma. | inflammatory pseudotumor (ipt)-like follicular dendritic cell (fdc) sarcoma is a recently described rare tumor and considered a unique entity, with different histologic appearances and behavior from those of the classical fdc sarcoma. this study analyzed the clinical and pathological findings of two such cases that the authors encountered and 36 previously reported cases identified in the literature. assessment of all 38 cases showed a slight female predominance (2.2:1) with a median age of 56.5 ... | 2014 | 24966952 |
| dual expression of epstein-barr virus, latent membrane protein-1 and human papillomavirus-16 e6 transform primary mouse embryonic fibroblasts through nf-κb signaling. | the prevalence of epstein-barr virus (ebv) and high-risk human papilloma virus (hpv) infections in patients with oral cancer in okinawa, southwest islands of japan, has led to the hypothesis that carcinogenesis is related to ebv and hpv co-infection. to explore the mechanisms of transformation induced by ebv and hpv co-infection, we analyzed the transformation of primary mouse embryonic fibroblasts (mefs) expressing ebv and hpv-16 genes, alone or in combination. expression of ebv latent membrane ... | 2014 | 24966902 |
| epstein-barr virus induced hemophagocytic lymphohistiocytosis in x-linked lymphoproliferative disease. | x-linked lymphoproliferative disease (xlp) is a rare, often fatal genetic disorder characterized by extreme vulnerability to epstein-barr virus (ebv). ebv-induced hemophagocytic lymphohistiocytosis (hlh) is a known presentation in xlp. in ebv-induced hlh in xlp, the brain imaging findings in the acute phase include a non specific pattern. in this report, we highlight the magnetic resonance imaging and magnetic resonance spectroscopy findings in a child with ebv induced hlh in xlp. | 2014 | 24966560 |
| histopathological features and their prognostic impact in nodular lymphocyte-predominant hodgkin lymphoma--a matched pair analysis from the german hodgkin study group (ghsg). | nodular lymphocyte-predominant hodgkin lymphoma (nlphl) is a rare lymphoma entity. we performed a matched-pair analysis to evaluate the prognostic impact of several histopathological features in this distinct hodgkin lymphoma subtype. lymph node samples of nlphl patients were tested for cd15, igd, phosphorylated stat6, icos and epstein-barr virus status of the malignant lymphocyte-predominant cells as well as epithelioid cell clusters and activated t cells in the microenvironment. none of these ... | 2014 | 24965443 |
| proposal of a clinical typing system and generation of a prognostic model in patients with nasopharyngeal carcinoma from southern china. | to propose a novel clinical typing classification focusing on the distinct progression patterns of nasopharyngeal carcinoma (npc), to supplement our knowledge of the clinical-biological behavior, to provide useful knowledge for treatment planning, and to contribute to basic research in npc. | 2014 | 24965409 |
| activity of broad-spectrum t cells as treatment for adv, ebv, cmv, bkv, and hhv6 infections after hsct. | it remains difficult to treat the multiplicity of distinct viral infections that afflict immunocompromised patients. adoptive transfer of virus-specific t cells (vsts) can be safe and effective, but such cells have been complex to prepare and limited in antiviral range. we now demonstrate the feasibility and clinical utility of rapidly generated single-culture vsts that recognize 12 immunogenic antigens from five viruses (epstein-barr virus, adenovirus, cytomegalovirus, bk virus, and human herpe ... | 2014 | 24964991 |
| fatal pulmonary complications in an immunodeficient child with chronic active epstein-barr virus infection. | primary epstein-barr virus infection in children typically presents as infectious mononucleosis and in immunocompetent individuals severe pneumonitis proves to be a rare complication. chronic active epstein-barr virus infection (caebv) is associated with multiple life-threatening conditions, including interstitial lung disease with fibrosis and lymphoid and lymphohistiocytic infiltrations. we report on a pediatric patient in whom caebv resulted in severe pneumopathy with a fatal outcome. | 2014 | 24964240 |
| dna methylation accumulation and its predetermination of future cancer phenotypes. | aberant dna methylation is a common epigenomic alteration in carcinogenesis. comprehensive analyses of dna methylation have stratified gastrointestinal cancer into several subgroups according to specific dna methylation accumulation. in gastric cancer, helicobacter pylori infection is a cause of methylation accumulation in apparently normal mucosa. epstein-barr virus infection is another methylation inducer that causes more genome-wide methylation, resulting in the formation of unique epigenotyp ... | 2014 | 24962701 |
| comparison of different rabbit atg preparation effects on early lymphocyte subset recovery after allogeneic hsct and its association with ebv-mediated ptld. | rabbit antithymocyte globulin (atg) is commonly used before allogeneic hematopoietic stem cell transplantation (allo-hsct) to prevent graft-versus-host disease. studies comparing the effect of different atg preparations and dosages on immune reconstitution and risk for epstein-barr virus (ebv)-mediated post-transplant lymphoproliferative disorder (ptld) are rare. | 2014 | 24962343 |
| pathobiology of hodgkin lymphoma. | hodgkin's lymphoma is a lymphoid tumour that represents about 1% of all de novo neoplasms occurring every year worldwide. its diagnosis is based on the identification of characteristic neoplastic cells within an inflammatory milieu. molecular studies have shown that most, if not all cases, belong to the same clonal population, which is derived from peripheral b-cells. the relevance of epstein-barr virus infection at least in a proportion of patients was also demonstrated. the real/who classifica ... | 2014 | 24959337 |
| mobile elements and viral integrations prompt considerations for bacterial dna integration as a novel carcinogen. | insertional mutagenesis has been repeatedly demonstrated in cancer genomes and has a role in oncogenesis. mobile genetic elements can induce cancer development by random insertion into cancer related genes or by inducing translocations. l1s are typically implicated in cancers of an epithelial cell origin, while alu elements have been implicated in leukemia as well as epithelial cell cancers. likewise, viral infections have a significant role in cancer development predominantly through integratio ... | 2014 | 24956175 |
| plasmodium falciparum infection is associated with epstein-barr virus reactivation in pregnant women living in malaria holoendemic area of western kenya. | the role of plasmodium falciparum malaria in epstein-barr virus (ebv) transmission among infants early in life remain elusive. we hypothesized that infection with malaria during pregnancy could cause ebv reactivation leading to high ebv load in circulation, which could subsequently enhance early age of ebv infection. pregnant women in kisumu, where p. falciparum malaria is holoendemic, were actively followed monthly through antenatal visits (up to 4 per mother) and delivery. using real-time quan ... | 2015 | 24951129 |
| primary epstein-barr virus infection diffusing f18-fluorodeoxyglucose-positron emission tomography/computed tomography response monitoring of hodgkin's disease: a case report. | hodgkin's disease is highly curable by radiotherapy and/or chemotherapy, but refractory disease or early relapses are rarely cured by conventional salvage therapy. | 2014 | 24950966 |
| secondary diffuse large b-cell lymphoma after chemotherapy for acute myeloid leukemia: looking for the unexpected diagnosis. | development of epstein-barr virus (ebv) positive lymphoproliferative disorders in patients with immunosuppression has become more frequently reported. a patient with acute myeloid leukemia was treated to remission, when on follow-up 9 months after his initial diagnosis, he was noted to have a generalized rash and lymphadenopathy. evaluation of skin and bone marrow biopsies was suggestive of a relapsed leukemia, and treatment was initiated. fever evaluation revealed a high load of ebv in his bloo ... | 2014 | 24950422 |
| a computationally designed inhibitor of an epstein-barr viral bcl-2 protein induces apoptosis in infected cells. | because apoptosis of infected cells can limit virus production and spread, some viruses have co-opted prosurvival genes from the host. this includes the epstein-barr virus (ebv) gene bhrf1, a homolog of human bcl-2 proteins that block apoptosis and are associated with cancer. computational design and experimental optimization were used to generate a novel protein called bindi that binds bhrf1 with picomolar affinity. bindi recognizes the hydrophobic cleft of bhrf1 in a manner similar to other bc ... | 2014 | 24949974 |
| hla-a snps and amino acid variants are associated with nasopharyngeal carcinoma in malaysian chinese. | nasopharyngeal carcinoma (npc) arises from the mucosal epithelium of the nasopharynx and is constantly associated with epstein-barr virus type 1 (ebv-1) infection. we carried out a genome-wide association study (gwas) of 575,247 autosomal snps in 184 npc patients and 236 healthy controls of malaysian chinese ethnicity. potential association signals were replicated in a separate cohort of 260 npc patients and 245 healthy controls. we confirmed the association of hla-a to npc with the strongest si ... | 2015 | 24947555 |
| hematopoietic cell transplantation for plasmablastic lymphoma: a review. | plasmablastic lymphoma (pbl) is recognized by the world health organization as a very aggressive subtype of non-hodgkin lymphoma. it was initially described in the setting of human immunodeficiency virus (hiv) infection, but it has since been identified in immunocompetent patients, as well. pbl is characterized by cd20 negativity and is associated with epstein-barr virus infection. the outcome with available therapy is poor, with median survival of less than 1 year. multiple adverse prognostic f ... | 2014 | 24946718 |
| race/ethnic and socioeconomic differences in stress and immune function in the national longitudinal study of adolescent health. | stress and immune function may be important mediators of the strong association between social factors and health over the life course, but previous studies have lacked the data to fully explore these links in a population-based sample. this study utilizes data from waves i-iv of the u.s. national longitudinal study of adolescent health (add health) to test the associations of race/ethnicity and socioeconomic status (ses) with levels of perceived stress and exposure to stressful life events (sle ... | 2014 | 24946263 |
| attachment anxiety is related to epstein-barr virus latency. | attachment theory provides a framework for understanding individual differences in chronic interpersonal stress. attachment anxiety, a type of relationship insecurity characterized by worry about rejection and abandonment, is a chronic interpersonal stressor. stress impacts cellular immunity, including herpesvirus reactivation. we investigated whether attachment anxiety was related to the expression of a latent herpesvirus, epstein-barr virus (ebv), when individuals were being tested for breast ... | 2014 | 24945717 |
| the first endogenous herpesvirus, identified in the tarsier genome, and novel sequences from primate rhadinoviruses and lymphocryptoviruses. | herpesviridae is a diverse family of large and complex pathogens whose genomes are extremely difficult to sequence. this is particularly true for clinical samples, and if the virus, host, or both genomes are being sequenced for the first time. although herpesviruses are known to occasionally integrate in host genomes, and can also be inherited in a mendelian fashion, they are notably absent from the genomic fossil record comprised of endogenous viral elements (eves). here, we combine paleovirolo ... | 2014 | 24945689 |
| tumor microenvironment and rig-i signaling molecules in epstein barr virus-positive and -negative classical hodgkin lymphoma of the elderly. | classical hodgkin lymphoma (chl) is a b-cell neoplasm characterized by hodgkin and reed-sternberg (hrs) cells. its prevalence exhibits a bimodal pattern of peaking in young adults and the elderly. there is an association with epstein-barr virus (ebv) infection in about 50% of cases of chl of the elderly, and the outcome of these patients is unfavorable. it is not well known how the latent infection of ebv is involved in the pathophysiology of chl of the elderly. to address this issue, we examine ... | 2014 | 24942949 |
| a de novo monoclonal immunoglobulin deposition disease in a kidney transplant recipient: a case report. | myeloma following kidney transplantation is a rare entity. it can be divided into two groups: relapse of a previous myeloma and de novo myeloma. some of these myelomas can be complicated by a monoclonal immunoglobulin deposition disease, which is even less common. less than ten cases of monoclonal immunoglobulin deposition disease after renal graft have been reported in the literature. the treatment of these patients is not well codified. | 2014 | 24942882 |
| latent membrane protein 1 and the b lymphocyte-a complex relationship. | the epstein barr virus (ebv)-encoded latent membrane protein 1 (lmp1) exerts numerous impacts on the functions of b lymphocytes, the cell type in which ebv establishes long-term latent infections. lmp1 expression has been implicated in making important contributions to a variety of human malignancies, as well as to autoimmune diseases. ebv also infects other types of immune cells, as well as nasopharyngeal epithelium, and evidence suggests that lmp1 functions may differ among cell types. in this ... | 2014 | 24941072 |
| clinical analysis of 102 cases of epstein-barr virus infections in chinese children. | the purpose of this study is to investigate the clinical manifestations and disease severity, to evaluate the recent trend of clinical manifestations and differences in the clinical and laboratory findings of ebv-associated im (infectious mononucleosis) according to the age of children. we retrospectively collected cases on hospitalized patients a majority of 7 years old with characteristic symptoms of im and serologically diagnosed ebv-associated im at shaanxi provincial peoples university hosp ... | 2014 | 24940855 |
| hits-clip and par-clip advance viral mirna targetome analysis. | mirnas regulate gene expression by binding predominantly to the 3' untranslated region (utr) of target transcripts to prevent their translation and/or induce target degradation. in addition to the more than 1200 human mirnas, human dna tumor viruses such as kaposi's sarcoma-associated herpesvirus (kshv) and epstein-barr virus (ebv) encode mirnas. target predictions indicate that each mirna targets hundreds of transcripts, many of which are regulated by multiple mirnas. thus, target identificatio ... | 2014 | 24940765 |
| the expression of renal epstein-barr virus markers in patients with lupus nephritis. | the aim of this study was to investigate the role of renal epstein-barr virus (ebv) infection in the pathogenesis of lupus nephritis (ln). a total of 58 renal tissue samples from patients with ln, seven normal renal tissue samples from patients with non-glomerular hematuria and 37 renal tissue samples from patients with minimal change nephropathy were collected. the expression of ebv-latent membrane protein-1 (ebv-lmp1) and ebv-encoded rna 1 (eber-1) in the renal tissue was examined by immunohis ... | 2014 | 24940399 |
| continuity and innovation in the data collection protocols of the second wave of the national social life, health, and aging project. | the second wave (w2) of the national social life, health, and aging project (nshap), a nationally representative, longitudinal survey of older adults now between the ages of 62 and 90, conducted approximately 3,400 interviews. selected coresidential romantic partners as well as w1 panel nonrespondents were selected for w2. data collection included in-person questionnaires, up to 15 biomeasures, and a post-interview questionnaire. | 2014 | 24939998 |
| chronic active epstein-barr virus infection complicated with multiple artery aneurysms. | 2014 | 24939943 | |
| hiv-related nk/t-cell lymphoma in the brain relapsed during intensive chemotherapy but regressed after chemotherapy discontinuation: the importance of maintaining cellular immunity. | this study reports a case of human immunodeficiency virus (hiv)-related natural killer/t-cell lymphoma with an unexpected clinical course. the lymphoma cells were positive for epstein-barr virus and the primary nodal lesions regressed after chemotherapy and combined antiretroviral therapy (c-art); however, brain metastasis progressed along with a reduction in the cd8+ t-cell count. chemotherapy was discontinued and the patient was treated with c-art alone, resulting in regression of the brain le ... | 2014 | 24938379 |
| prevalence and prognostic significance of epstein-barr virus infection in classical hodgkin's lymphoma: a meta-analysis. | the prevalence and prognostic significance of epstein-barr virus (ebv) infection in classical hodgkin's lymphomas (chls) remain elusive. to examine the epidemiological and prognostic differences between ebv-positive and -negative chls, we conducted a meta-analysis of 119 published studies including 13,045 cases. | 2014 | 24937173 |
| clinical features, genetics, and outcome of pediatric patients with hemophagocytic lymphohistiocytosis in korea: report of a nationwide survey from korea histiocytosis working party. | we analyzed a nationwide registry of pediatric patients with hemophagocytic lymphohistiocytosis (hlh) in korea to assess the clinical and genetic features and treatment outcomes in pediatric hlh. | 2015 | 24935083 |
| connective tissue diseases: epstein-barr virus in sjögren's syndrome salivary glands drives local autoimmunity. | 2014 | 24934188 | |
| a possible familial lymphoproliferative disorder in two male siblings of children with recurrent wheezing and lung infections since infancy. | malignancies that result in wheezing in infants are very uncommon. given its rarity in children, the diagnosis is challenging, and in the absence of a high index of suspicion, delayed diagnosis is not uncommon. here we report two male siblings of children who presented with recurrent wheezing and recurrent lung infections since infancy. both children showed no laboratory evidence of immunodeficiency. lymphocytic interstitial pneumonia or hypersensitivity pneumonitis was histologically suspected ... | 2014 | 24934116 |
| lymphomatoid granulomatosis involving the central nervous system: a case report and review of the literature. | lymphomatoid granulomatosis (lyg) is a rare tumor with unknown etiology. specific etiological factors for lyg are also unknown, although previous data indicates that lyg is an epstein-barr virus-associated b-cell proliferation associated with an exuberant t-cell reaction. according to the 2008 who classification, lyg is characterized by b-cell proliferation of b-lymphoma cells. generally, treatment options for lyg are similar to those for diffuse large b-cell lymphoma. unfortunately, lyg is a ch ... | 2014 | 24932245 |
| burkitt lymphoma: epidemiological features and survival in a south african centre. | the epidemiology of burkitt lymphoma (bl) shows that the endemic type is mainly confined to equatorial africa and has a very close association with the epstein-barr virus (ebv), while the sporadic variant shows only a 20% association with ebv and is seen mainly in europe and north america. an immunodeficent form of bl has been described more recently. this study aimed to describe the epidemiological characteristics and survival of children presenting with bl to tygerberg hospital, cape town, in ... | 2014 | 24932211 |
| pityriasis rubra pilaris (prp) with preceding epstein-barr virus infection: a new type prp with non-hiv virus infection? | 2014 | 24931263 | |
| improved elongation factor-1 alpha-based vectors for stable high-level expression of heterologous proteins in chinese hamster ovary cells. | establishing highly productive clonal cell lines with constant productivity over 2-3 months of continuous culture remains a tedious task requiring the screening of tens of thousands of clonal colonies. in addition, long-term cultivation of many candidate lines derived in the absence of drug selection pressure is necessary. expression vectors based on the elongation factor-1 alpha (eef1a) gene and the dihydrofolate reductase (dhfr) selection marker (with separate promoters) can be used to obtain ... | 2014 | 24929670 |
| ebi3 is pivotal for the initiation of experimental autoimmune uveitis. | murine experimental autoimmune uveitis (eau) is a model for human autoimmune uveitis, whose pathogenesis is caused by both th1 and th17 cell responses. epstein-barr virus-induced gene 3 (ebi3) is a component of the heterodimeric cytokines: interleukin (il)-27 and il-35. although il-27 was shown to initiate th1 cell development, it is also recognized as a negative regulator of fully activated cd4+ t cells, including th17 cells. recently, il-35 also has also been reported to play immunosuppressive ... | 2014 | 24929202 |
| methotrexate-associated lymphoproliferative disorders of the tongue developing in patients with rheumatoid arthritis: a report of 2 cases and a review. | incidences of lymphoproliferative disorders (lpds) in patients with compromised immune systems associated with immunosuppressants such as methotrexate (mtx) administered for the treatment of rheumatoid arthritis (ra) are reportedly increasing. although extranodal lesions develop in half of the patients with mtx-associated lpds, only a few studies have reported on intraoral lesions. we evaluated 2 elderly women with mtx-associated lpds who had received mtx for the treatment of ra and presented wi ... | 2015 | 24927637 |
| [severe lactic acidosis revealing hematologic malignancy]. | a 75-year-old woman is hospitalised for sepsis. the diagnosis of cholecystitis is made and an antibiotic therapy is debuted. the clinical worsening leads to realise an urgent cholecystectomy. a sepsis like shock persisted. the antibiotherapy was changed and a second abdominal look made. a severe lactic acidosis persisted since the cholecystectomy despite a continuous hemofiltration. the diagnosis of type b lactic acidosis secondary to malignancy was suspected. an osteomedullar biopsy revelled b- ... | 2014 | 24927632 |
| management of advanced nk/t-cell lymphoma. | nk/t-cell lymphomas are aggressive malignancies, and the outlook is poor when conventional anthracycline-containing regimens designed for b-cell lymphomas are used. with the advent of l-asparaginase-containing regimens, treatment outcome has significantly improved. l-asparaginase-containing regimens are now considered the standard in the management of nk/t-cell lymphomas. in advanced diseases, however, outcome remains unsatisfactory, with durable remission achieved in only about 50% of cases. st ... | 2014 | 24924658 |