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responses of calf kidney cells to human adenovirus type 12. 19715316575
the nature of tumor antigen of adenovirus type 12 and its formation in cultured cells after infection. 19665296935
titration of adenovirus type 12 and type 18 in human embryonic kidney cell cultures. 19665296932
the fate of the dna of adenovirus type 12 in baby hamster kidney cells. 19685248820
[complement fixing antibodies to the thermostable component of adenovirus type 12 t-antigen in the serum of cancer patients]. 19715137544
temperature-sensitive mutants of human adenovirus type 12. 19715125575
three size-classes of intracellular adenovirus deoxyribonucleic acid.when human adenovirus type 2 or 12 infects cells, either productively or non-productively, three classes of viral deoxyribonucleic acid (dna) are found within the cells: (i) viral dna which cosediments with dna extracted from infectious adenovirions at 31.3s for adenovirus type 2 and at 29.0s for adenovirus type 12, (ii) viral dna which sediments at about 18s, and (iii) viral dna which sediments at >45s and is apparently integrated into the cellular dna. a precursor-product relationship is sugge ...19715105670
intracellular forms of adenovirus deoxyribonucleic acid. i. evidence for a deoxyribonucleic acid-protein complex in baby hamster kidney cells infected with adenovirus type 12.the total intracellular deoxyribonucleic acid (dna) from baby hamster kidney cells abortively infected with (3)h-adenovirus type 12 was analyzed in dye-buoyant density gradients. between 10 and 20% of the cell-associated radioactivity derived from viral dna bands in a density position which is 0.043 to 0.085 g/cm(3) higher than that of viral dna extracted from purified virions. the dna in the high-density region (hp-fraction) is almost completely absent when dna, ribonucleic acid (rna) or protei ...19725062681
[interfering activity of cold-adapted strains of adenovirus types 2 and 4 with adenovirus type 12]. 19725062526
the dna of adenovirus type 12 and its denaturation pattern. 19725058840
genetic studies with tumorigenic adenoviruses. 3. recombination in adenovirus type 12. 19725058331
[the effect of intraperitoneal or subcutaneous immunization with tumor cell membranes on the enhancement of adenovirus type 12 induced tumors in hamsters]. 19725055039
characterization of adenovirus dna in kb cells infected with adenovirus type 12. 19725039024
[immunological analysis of hamster sarcoma induced by adenovirus type 12]. 19704991659
[transformation of newborn green monkey kidney cell cultures induced by adenovirus type 12]. 19704990486
[oncogenic properties of human adenovirus type 12 for certain mammals]. 19664988196
[tumor antigens induced by adenovirus type 12 in hamster tumors]. 19694985411
wasting syndrome in thymectomized immature baboons (papio species) after infection with adenovirus type 12. 19674962026
immunofluorescence of human adenovirus type 12 in various cell types. 19664956667
spontaneous and adenovirus type 12-induced chromosome aberrations in fanconi's anaemia fibroblasts. 19714934498
detection by immunofluorescence of surface antigens in cells from tumours induced in hamsters by adenovirus type 12. 19704921446
loss of t antigen by cells derived from a hamster tumour induced by adenovirus type 12. 19704918837
association of adenovirus type 12 deoxyribonucleic acid with host cell chromosomes.preparations of purified (3)h-labeled adenovirus type 12 ((3)h-ad. 12) were analyzed for radioactive impurities by millipore filtration and ultracentrifugation. it was found that only about 1% of the isotope activity was separable from the virions. exposure of hamster cell lines to (3)h-ad. 12 resulted in nonlytic infections, and autoradiography indicated that viral deoxyribonucleic acid (dna), or parts thereof, became associated with host cell chromosomes. usually, the label was observed in the ...19684911853
t antigen from nuclear and cytoplasmic extracts from an adenovirus type 12 transformed cell line. 19694901393
establishment of a malignant cell line derived from human adenovirus type 12-induced hamster tumor in tissue culture. 19684899948
inhibition of tumor growth by polyinosinic-polycytidylic acid.the synthetic double-stranded rna, polyinosinic-cytidylic acid, inhibits the growth of some tumors in mice. two days after implantation of a reticulum cell sarcoma, a lymphatic lymphoma, a fibrosarcoma, two leukemias, and a human adenovirus 12-induced tumor, treatment of groups of mice resulted in decreased growth rates of the tumors and increased survival times of the animals. in the two tumors tested (the reticulum cell sarcoma and the adenovirus 12-induced tumor) initiation of treatment after ...19694894326
in vitro transformation of hamster embryonic kidney cultures exposed to human adenovirus 12. 19694884654
changes accompanying long term tissue culture of an adenovirus type 12 tumour cell line. 19684883920
a search for a complement-fixing antibody in cancer patients against the tumor antigen of adenovirus type 12. 19684874890
pathological studies on the oncogenesis of adenovirus type 12 in hamsters. 19674870978
temperature-sensitive mutants of adenovirus type 12 defective in viral dna synthesis.ten temperature-sensitive (ts) mutants of adenovirus type 12 which produce plaques at 31 but not at 38.5 c have been isolated after mutagenesis with nitrosoguanidine or nitrous acid. the mutants have been classified into six separate complementation groups. dna-dna hybridizations have shown that at 38.5 c the ts 401 and 406 mutants of groups b and e, respectively, synthesized less than 10% of the normal level of viral dna. the two mutants were also defective in the production of late proteins at ...19744854616
susceptibility of xeroderma pigmentosum cells to chromosome breakage by adenovirus type 12. 19744845660
the polypeptides of adenovirus type 12. 19734753438
ultrastructural findings of adenovirus type 12-induced tumor cells treated by differential hypothermia. 19724675118
undifferentiated intraperitoneal tumors induced by human adenovirus type 12 in hamsters.a single intraperitoneal inoculation of 0.01 ml of virus fluid, 10(3.5) to 10(4.5) tcid(50) hela cells/0.1 ml, was made in 12 newborn hamsters. from 28 to 96 days after the virus inoculation, all 12 hamsters developed multiple, multicentric tumors in the peritoneal cavity. histopathologic observations on these abdominal tumors strongly suggest that the so-called adenovirus-typical undifferentiated neoplasm produced by intraperitoneal inoculation may originate in part from a neuronal precursor ce ...19724634738
temperature-sensitive mutants of human adenovirus type 12. 19724631614
comparative studies on functions of human adenovirus type 12 and its low oncogenic mutant virions.physical and biological properties of highly oncogenic human adenovirus type 12 were compared with a low oncogenic mutant (cyt mutant). parental and cyt mutant virions had very similar density and dna size. however, the parental strain virion preparations contained a much higher proportion of defective virions (capable of cell killing, but not able to induce t- or v-antigen) than cyt mutant stock. it was also found that cyt mutant had a reduced virus yield in several human cell lines compared wi ...19744607584
retinoblastoma-like tumors induced by human adenovirus type 12 in rats. 19744600165
alternate changes of surface antigen(s) in adenovirus type 12-transformed and tumor cells. 19734582980
detection of a specific surface antigen(s) in adenovirus type 12-transformed cells by fluorescent antibody technique. 19734582979
interactions of adenovirus type 12 with host cell chromosomes. 19734571264
extraocular orbital tumors induced by human adenovirus type 12 in hamsters. 19734571073
relationship among tumorigenicity, t antigen, and virus-specific transplantation antigen in adenovirus type 12 transformed and tumor cells. 19724561276
induction of intracranial tumors in mice by human adenovirus type 12. 1. immunofluorescent studies on t antigen and the predilection sites for tumor development in the brain. 19724560122
immunofluorescence of arginine deprived cells infected with adenovirus type 12. 19724556503
proceedings: studies on the transcription of adenovirus type 12. 19744461566
ultrastructural findings in medulloepitheliomatous neoplasms induced by human adenovirus 12 in rodents. 19744446933
production of high titres of interferon in chicken leukocyte cultures inoculated with human adenovirus type 12. 19704394990
disappearance of tumors induced by adenovirus type 12 after differential hypothermia treatment. 19724378404
biological properties of "baby taiwan monkey" strains of human adenovirus type 12. 19744376737
cytogenetic studies in permissive and abortive infections by adenovirus type 12. 19744376513
dual infection of hamsters with adenovirus type 12 and type 6. 19744372120
transformation by adenovirus type 12 of rat embryol fibroblasts cultivated in the presence of interferon. 19744366216
antiviral activity of tobacco smoke condensate on encephalomyocarditis infection in mice.a water-soluble nontumorigenic acidic fraction of tobacco smoke condensate of cigarettes has been found to have antiviral activity against encephalomyocarditis (emc) virus infection in mice. the portion of lower molecular weight was inhibitory to the growth of emc virus, vesicular stomatitis virus, reovirus type 2, vaccinia virus, and poliovirus type 2, but not against adenovirus type 12, in kb cell cultures. the cigarette smoke agent did not induce serum interferon although it protected mice fr ...19734364177
primary brain and spinal cord tumors induced by human adenovirus type 12 in hamsters. 19734357158
[change in some properties of adenovirus type 12 following uv irradiation]. 19724351666
adenovirus type 12 surface antigen detected by immunofluorescence in infected kb cells. 19734350219
inhibition of adenovirus type 12 induced dna synthesis in g1-arrested bhk21 cells by dibutyryl adenosine cyclic 3':5'-monophosphate. 19724349671
cycl amp in gl-arrested bhk21 cells infected with adenovirus type 12. 19734345893
synthesis of viral components in hybrids of differentially permissive cells infected with adenovirus type 12. 19724343019
multiplicity reactivation of human adenovirus type 12 and simian virus 40 irradiated by ultraviolet light. 19714328814
demonstration and identification of cytotoxic antibodies and antibodies blocking the cell-mediated antitumor immunity against adenovirus type 12-induced tumors. 19714327089
effect of adenovirus type 12 on tumor induction by sv40 and para (defective sv40). 19714322932
[the behavior of adenovirus type 12 in the bodies of monkeys]. 19704316399
adenovirus transformation of hamster embryo cells.inoculation of hamster embryo cell cultures with human adenovirus type 12 (ad12) or simian adenovirus (sa7) resulted in the formation of foci of morphologically transformed cells within 12 days. the rapid appearance of well-defined foci was dependent upon the transfer of cells into new plates, with sufficient dilution after virus adsorption, and was independent of virus dose. dose-response studies showed linearity of focus formation with dilution of ad12 or sa7. results averaged from several exp ...19684316017
hybridization of rna from rous sarcoma virus with cellular and viral dna's.the rna of rous sarcoma virus (rsv) hybridizes with dna's isolated from all eukaryotes tested (animal and plant) with the possible exception of yeast. bacterial dna's show no homology to rsv-rna. dna's from the oncogenic viruses, adenovirus type 12 and sv40 show significant homology with rsv-rna, but those from nononcogenic adenoviruses types 2 and 4 are not homologous.rsv-rna hybridized to all of the dna's examined has the same, or a closely similar, base composition. moreover, the melting temp ...19694313332
relationship between potentiation of h-1 growth by human adenovirus 12 and inhibition of the 'helper' adenovirus by h-1. 19694309922
effect of bcg and allogeneic tumor cells on adenovirus type 12 tumorigenesis in mice. 19694303807
human cell strains susceptible to focus formation by human adenovirus type 12. 19684303477
oncogenicity of mixtures of adeno-associated virus and adenovirus type 12. 19684302692
persistence of the viral genome in adenovirus type 12-infected hamster cells.induction of t antigen by adenovirus type 12 was studied in growing and growth-inhibited cultures of the nil-2 line of syrian hamster cells. at a viral input multiplicity of 10, neoantigen was present in 100% of the cells by 24 hr. t antigen gradually disappeared in descendants of these cells so that 2 weeks after infection only 1% gave specific immunofluorescence. when cellular replication was prevented by addition of fluorodeoxyuridine, t antigen persisted in all cells for the 2-week period. u ...19684302189
chromosomal aberrations and cloning efficiency in adenovirus type 12-infected hamster cells.the fate of hamster cells, abortively infected with adenovirus type 12, has been studied by correlation of chromosomal aberrations with induction of t antigens and cloning efficiency. the incidence of chromosomal changes paralleled to some extent the t antigen formation, but was inversely related to the cloning efficiency of the cells. at an input multiplicity of 100, within 24 hr after infection, nearly all of the cells or metaphases revealed the presence of t antigens and chromosomal lesions, ...19684302188
chromosomal and autoradiographic studies of cells infected with herpes simplex virus.the induction of chromosomal aberrations by herpes simplex virus (hsv) and the interaction between viral deoxyribonucleic acid (dna) and chromosomes have been studied (i) by infection of the bhk-21 line of hamster kidney cells at multiplicities ranging from 0.5 to 100 followed by 1-hr pulses of (3)h-thymidine preceding preparation at varying intervals of metaphases and autoradiography, and (ii) by use of (3)h-thymidine-labeled hsv for infection, chromosomal, and autoradiographic analyses at inte ...19684302015
relationship between the subunits and "t" antigens of adenovirus type 12. 19674293730
increased tumour induction by adenovirus type 12 in thymectomized mice and mice treated with anti-lymphocyte serum. 19674293728
in vitro demonstration of humoral and cell-bound immunity against common specific transplantation atigen(s) of adenovirus 12-induced mouse and hamster tumors.a colony inhibition (ci) technique was used to demonstrate in vitro tumor-specific antigenicity common for neoplasms induced by the adenovirus type 12. immunization of mice against syngeneic mouse adeno 12 tumor cells evoked immunity demonstrable against other adeno 12 neoplasms of mice and of hamster as well. the immunity was detected as antibody activity in the sera of specifically immunized mice and as a similar activity of the lymph node cells of these animals. the finding in transplantation ...19674290563
adenovirus tumorigenesis: role of the viral genome in determining tumor morphology.adenovirus type 12 transforms the fibroblastic bhk21 (baby hamster kidney) cell line into rounded or cuboidal cells that give rise in hamsters to undifferentiated small cell sarcomas indistinguishable from those induced in newborn hamsters by inoculation of the virus itself. in contrast. cells from this line transformed by polyoma virus retain their fibroblastic morphology and induce fibrosarcomas in hamsters. this suggests that the morphology of tumors induced by the adenovirus-transformed cell ...19674290540
infrequent c-f antibody response in mice with adenovirus type 12 tumors. 19674290454
in vitro transformation by the adenovirus-sv40 hybrid viruses. 3. morphology of tumors induced with transformed cells.tumors induced with hamster kidney cells transformed by the adeno 2-, adeno 3-, adeno 7-, and adeno 12-sv40 hybrid viruses, and by adenovirus type 12, were examined histologically. the tumors induced with adeno 2-, adeno 3-, and adeno 7-sv40-transformed cells were similar to tumors induced with sv40-transformed hamster kidney cells but contained cells intermediate in morphology between sv40 and adenovirus tumor cells and occasionally contained nests of adenovirus-like cells. cells transformed by ...19674289742
in vitro transformation by the adenovirus-sv40 hybrid viruses. ii. characteristics of the transformation of hamster cells by the adeno 2-, adeno 3-, and adeno 12-sv40 viruses.primary weanling hamster kidney cultures were transformed with the adeno 2-sv40, adeno 3-sv40, and adeno 12-sv40 hybrid viruses and with adenovirus type 12. the transformed cell lines which were established were characterized with respect to morphology, virus and antigen content, and chromosome aberrations. the adeno 2 and adeno 3-sv40 hybrid transformed cells had the morphology and t antigen content characteristic of sv40 transformations; cells transformed by the former hybrid had cytogenetic c ...19674289741
histogenesis of malignant neoplasm induced by adenovirus type 12. 19664289177
enhanced growth of human embryonic cells infected with adenovirus 12.fibroblast-like cells from human embryonic lung were infected with adenovirus type 12, and they survived as an established line, with the characteristics of "transformation" following considerable cellular killing. inclusion bodies disappeared and cells became resistant to reinfection with type 12 virus as they grew in thick multilayered strands, and giant and syncytial cells became commonplace. an induced new cell antigen demonstrable by complement-fixation and fluorescent-antibody studies pers ...19664288593
double infection of newborn syrian hamsters with simian virus 40 and human adenovirus 12. 19664287847
potentiation of oncogenicity of adenovirus type 12 grown in african green monkey kidney cell cultures preinfected with sv40 virus. persistence of both t antigens in the tumors and evidence for possible hybridization. 19664287351
virus-induced transplantation immunity to human adenovirus type 12 tumors of the hamster and mouse. 19664287123
interaction of a simian papovavirus and adenoviruses. i. induction of adenovirus tumor antigen during abortive infection of simian cells.feldman, lawrence a. (baylor university college of medicine, houston, tex.), janet s. butel, and fred rapp. interaction of a simian papovavirus and adenoviruses. i. induction of adenovirus tumor antigen during abortive infection of simian cells. j. bacteriol. 91:813-818. 1966.-adenovirus types 2, 7, and 12 undergo an abortive growth cycle in green monkey kidney cells; they induce the formation of adenovirus tumor antigen, but synthesis of adeno capsid antigen and infectious adenovirus was observ ...19664286827
brain tumors induced in rats by human adenovirus type 12. 19744275715
intracranial transplantation of the tumor induced by adenovirus type 12 in syrian hamster--an experimental brain tumor model. 19714264054
induction of intracranial tumors in mice by human adenovirus type 12. ii. enhancement by n,n'-dimethylnitrosourea. 19714263560
mitochondrial dna from hamster tumors induced by adenovirus type 12. 19704258713
immunofluorescent studies of antigens induced by adenovirus type 12. 19714252008
infection of human embryonic skin-muscle tissue culture cells with adenovirus type 12. 19664227144
effect of injection of adenovirus type 12 in adult hamsters. 19664226975
fine structure of negatively stained adenovirus type 12. 19654223616
electron microscopic studies on the tumor induced by adenovirus type 12. 19654223029
[electron microscopic studies of kidney cells of erythrocebus patas after infection with sv 40 and adenovirus type 12]. 19704193497
cytochemical observations on the adenovirus type-12-transformed hamster-embryo cell cultures. 19694186155
evidence for the igg nature of complement-fixing (cf) antibodies to adenovirus type 12 hamster tumor neoantigens. 19684169692
paracrystalline formation in cells infected by adenovirus type 12. 19724146130
defective virions in human adenovirus type 12.purified preparations of human adenovirus type 12 showed two bands when subjected to isopycnic centrifugation in a density gradient of cesium chloride. their density difference was about 0.003 g/ml, suggesting a small difference in their deoxyribonucleic acid to protein ratio. virions with a lighter density can kill human kb cells and induce t antigen as efficiently as the heavy virions. however, they appeared incapable to form plaques. two passages of the heavy infectious virions at low multipl ...19714106970
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