Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| Nigeria anopheles vector database: an overview of 100 years' research. | Anopheles mosquitoes are important vectors of malaria and lymphatic filariasis (LF), which are major public health diseases in Nigeria. Malaria is caused by infection with a protozoan parasite of the genus Plasmodium and LF by the parasitic worm Wuchereria bancrofti. Updating our knowledge of the Anopheles species is vital in planning and implementing evidence based vector control programs. To present a comprehensive report on the spatial distribution and composition of these vectors, all publis ... | 2011 | 22162764 |
| filariasis presenting as multiple subcutaneous nodules: a rare case report. | filariasis presenting as multiple subcutaneous nodules is very rare and only a very few cases are reported in the literature. microfilaria bancrofti is known to occur in different sites like breast, thyroid, lymph nodes, liver, lungs and body fluids, however, in contrast to the other filarial species, its occurrence in soft tissues is rarely reported. conventional method of diagnosis of filariasis is by demonstration of microfilaria in peripheral blood smear which may be diurnal or nocturnal. th ... | 2011 | 22156357 |
| lymphatic filariasis in western ethiopia with special emphasis on prevalence of wuchereria bancrofti antigenaemia in and around onchocerciasis endemic areas. | lymphatic filariasis is known to be endemic in gambella region, western ethiopia, but the full extent of its endemicity in other regions is unknown. a national mapping program for ethiopia was initiated in 2008. this report summarizes initial data on the prevalence of wuchereria bancrofti antigenaemia based on surveys carried out in a sampled population of 11685 individuals living in 125 villages (112 districts) of western ethiopia. the overall prevalence rate was 3.7%, but high geographical clu ... | 2011 | 22154976 |
| future prospects and challenges of vaccines against filariasis. | filarial infections remain a major public health and socio-economic problem across the tropics, despite considerable effort to reduce disease burden or regionally eliminate the infection with mass drug administration programs. the sustainability of these programs is now open to question due to a range of issues, not least of which is emerging evidence for drug resistance. vaccination, if developed appropriately, remains the most cost-effective means of long term disease control. the rationale fo ... | 2011 | 22150082 |
| the global programme to eliminate lymphatic filariasis: history and achievements with special reference to annual single-dose treatment with diethylcarbamazine in samoa and fiji. | diethylcarbamazine (dec), first introduced in 1947, was shown to have strong efficacy and safety for treatment of human lymphatic filariasis, which is caused mostly by a species wuchereria bancrofti. many studies to optimize the dosage and treatment schedule of dec followed, and, based on the results, control programs with various regimens were implemented in different endemic areas/countries. by the mid 1970s, with endorsement by the who expert committee on filariasis (3rd report, 1974), the st ... | 2011 | 22028608 |
| epidemiological and entomological evaluations after six years or more of mass drug administration for lymphatic filariasis elimination in nigeria. | the current strategy for interrupting transmission of lymphatic filariasis (lf) is annual mass drug administration (mda), at good coverage, for 6 or more years. we describe our programmatic experience delivering the mda combination of ivermectin and albendazole in plateau and nasarawa states in central nigeria, where lf is caused by anopheline transmitted wuchereria bancrofti. baseline lf mapping using rapid blood antigen detection tests showed mean local government area (lga) prevalence of 23% ... | 2011 | 22022627 |
| Microfilariae of Wuchereria bancrofti in urine: an uncommon finding. | Filariasis is a global health problem commonly seen in tropics and subtropics. Microfilariae has been reported in cytological specimens from various sites but is an unusual finding from sediments of centrifuged normally voided urine samples. This highlights the presence of adult worms in the lymphatics and thus helping in prompt decision to start antihelminthic treatment besides providing surgical treatment for chyluria. | 2011 | 21994197 |
| bayesian geostatistical modelling of malaria and lymphatic filariasis infections in uganda: predictors of risk and geographical patterns of co-endemicity. | in uganda, malaria and lymphatic filariasis (causative agent wuchereria bancrofti) are transmitted by the same vector species of anopheles mosquitoes, and thus are likely to share common environmental risk factors and overlap in geographical space. in a comprehensive nationwide survey in 2000-2003 the geographical distribution of w. bancrofti was assessed by screening school-aged children for circulating filarial antigens (cfa). concurrently, blood smears were examined for malaria parasites. in ... | 2011 | 21989409 |
| Management of bilateral uveitis secondary to intraocular filariasis. | 2011 | 21987687 | |
| Cross-reaction of antigen preparations from adult and larval stages of the parasite Setaria equina with sera from infected humans with Wuchereria bancrofti. | Crude antigenic preparations from Setaria equina were used in ELISA and Western blotting to examine cross-reaction with human sera from areas endemic for bancroftian filariasis. Sera from normal subjects from non-endemic areas were included as negative controls. Cross-reaction was found between S. equina antigens and antibodies in the sera of Wuchereria bancrofti-infected patients, with the highest levels observed between sera of chronic infected patients and Setaria spp. crude female worm surfa ... | 2011 | 21977571 |
| Impact of polystyrene beads as a mosquito control measure to supplement lymphatic filariasis elimination activities in Socotra Island, Yemen. | Lymphatic filariasis (LF) is targeted for worldwide elimination. In Yemen, all mainland implementation units met the WHO criteria for stopping mass drug administration (MDA) after 5 rounds. However, in Socotra Island these criteria were not met. Our study evaluated the efficacy of applying expanded polystyrene beads (EPBs) on the Culex population and the effect on LF transmission. Human and mosquito surveys were conducted in 40 randomly selected households in Hadibo (capital of Socotra) before a ... | 2011 | 21972477 |
| A 22 year follow-up study on lymphatic filariasis in Tanzania: analysis of immunological responsiveness in relation to long-term infection pattern. | Seventy-one individuals who had been examined for Wuchereria bancrofti microfilaraemia in 1975, some of whom had been offered mass treatment with diethylcarbamazine (DEC) in subsequent years, were re-identified in 1996 and examined for microfilaraemia, circulating filarial antigenemia and cellular and humoral immunoresponsiveness to crude antigen homogenates prepared from Brugia pahangi parasite material. 85.9% of the study individuals had the same infection status in 1975 and 1996, suggesting s ... | 2011 | 21964049 |
| wolbachia effects on host fitness and the influence of male aging on cytoplasmic incompatibility in aedes polynesiensis (diptera: culicidae). | the endosymbiotic bacteria wolbachia manipulate host reproduction by inducing a form of sterility known as cytoplasmic incompatibility (ci), promoting the invasion of infection into natural host populations. ci has received attention for use in applied strategies to control insect vectors of disease. thus, to understand both naturally occurring wolbachia invasions and evaluate potential applied strategies, it is important to understand wolbachia interactions with its host, including impacts on f ... | 2011 | 21936319 |
| development of loop-mediated isothermal amplification method for detecting wuchereria bancrofti dna in human blood and vector mosquitoes. | we have developed loop-mediated isothermal amplification (lamp) method to detect wuchereria bancrofti dna. the sensitivity and specificity of lamp method were equivalent to those of pcr method which detects sspi repeat sequence in w. bancrofti genomic dna: both methods detected one thousandth of w. bancrofti dna from one microfilaria (mf), and did not cross-react with dnas of brugia malayi, b. pahangi, dirofilaria immitis, human and culex quinquefasciatus. we also examined the sensitivity of lam ... | 2011 | 21930238 |
| Lymphatic filariasis in the Democratic Republic of Congo; micro-stratification overlap mapping (MOM) as a prerequisite for control and surveillance. | The Democratic Republic of Congo (DRC) has a significant burden of lymphatic filariasis (LF) caused by the parasite Wuchereria bancrofti. A major impediment to the expansion of the LF elimination programme is the risk of serious adverse events (SAEs) associated with the use of ivermectin in areas co-endemic for onchocerciasis and loiasis. It is important to analyse these and other factors, such as soil transmitted helminths (STH) and malaria co-endemicity, which will impact on LF elimination. | 2011 | 21923949 |
| [differential diagnosis of imported filariasis by molecular techniques (2006-2009)]. | the last few years has seen an increase in the number of immigrants and travellers from endemic areas where filariasis are mainly caused by loa loa (l. loa), mansonella perstans (m. perstans) and wuchereria bancrofti (w. bancrofti) species. these demographic changes has led to the need for better filariae species-specific molecular diagnostic tests to solve problems, as alternatives to the more time consuming classic parasitology methods. thus, the objective of the present work was the implement ... | 2011 | 21906850 |
| impact of basic lymphedema management and antifilarial treatment on acute dermatolymphangioadenitis episodes and filarial antigenaemia. | a major factor in the progression of lymphedema is acute dermatolymphangioadenitis (adla). | 2011 | 21887053 |
| transforming growth factor-+¦1 variant leu10pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis. | antigen testing and ultrasound detection have shown that many persons are infected with wuchereria bancrofti even though they do not have microfilariae (mf) in the blood. to ascertain the role of human host immunogenetics on the lack of circulating mf in the blood, 152 lymphatic filariasis (lf)-infected patients comprising 118 patients with microfilaremic (mf+, patent) infection and 34 patients with latent (mf-, antigen-positive) infection were recruited and genotyped for association of single n ... | 2011 | 21843572 |
| acquired alpha 1-antitrypsin deficiency in tropical pulmonary eosinophilia. | background & objectives : observation of an increased frequency of an intermediate deficiency of serum alpha1-antitrypsin (a1-at) in patients with tropical pulmonary eosinophilia (tpe) was earlier reported. though the possibility of existence of an acquired deficiency was suggested, without phenotyping a hereditary a1-at deficiency in tpe could not totally be ruled out. in this study, we have done pi (protease inhibitor) phenotyping to investigate the possibility of association of any heterozygo ... | 2011 | 21808138 |
| expression and characterization of cu/zn superoxide dismutase from wuchereria bancrofti. | the cu/zn superoxide dismutase gene from wuchereria bancrofti (cu/zn wbsod) was isolated by pcr using degeneracy primers. the complete cu/zn wbsod consisted of 1,032 nucleotides containing 4 exons (477 nucleotides) and 3 introns. the molecular phylogenetic analysis of the cu/zn wbsod gene in comparison with those from other organisms revealed that the gene was classified in the same clade to those of filarial brugia malayi and brugia pahangi (bootstrap value at 90). the nucleotide and deduced am ... | 2011 | 21796387 |
| progress toward elimination of lymphatic filariasis --- togo, 2000--2009. | lymphatic filariasis (lf) is a disabling, mosquito-borne disease of humans caused by the parasitic filarial nematodes wuchereria bancrofti, brugia malayi, and brugia timori. in 2000, the global program to eliminate lf (gpelf) was established with the objective of eliminating lf as a public health problem by 2020. at that time, 80 countries had ongoing transmission, with an estimated 1.34 billion persons at risk for infection and 120 million infected. this report describes the lf elimination prog ... | 2011 | 21796097 |
| ultrasonographic visualisation of live wuchereria bancrofti adult worms in situ. | 2011 | 21789875 | |
| recombinant wolbachia surface protein (wsp)-induced t cell responses in wuchereria bancrofti infections. | human lymphatic filariasis is a debilitating parasitic disease characterized by downregulation of the host's immune response in asymptomatic carriers along with profound hyperreactivity in chronic patients apart from putatively immune endemic normals. the endosymbiont wolbachia, a bacterium of filarial nematodes has received much attention as possible chemotherapeutic target and its involvement in disease pathogenesis. the role of recombinant wolbachia surface protein (rwsp), one of the most abu ... | 2011 | 21786068 |
| filarial dance-sonographic sign of filarial infection. | a 17-year-old boy presented with a 3-month history of swelling and vague pain in the scrotum. us revealed multiple anechoic cyst-like lesions in the body of left epididymis. these cysts showed tubular echogenic internal structures with peculiar twirling motion. this was recognised as the sonographic filarial dance-sign of live adult filarial worms. the boy subsequently underwent needle aspiration of the lesion, which microscopically demonstrated microfilaria of wuchereria bancrofti. our report i ... | 2011 | 21773794 |
| multiple insecticide resistance/susceptibility status of culex quinquefasciatus, principal vector of bancroftian filariasis from filaria endemic areas of northern india. | to understand the insecticide resistance status of culex quinquefasciatus say (diptera: culicidae) (cx. quinquefasciatus) to deltamethrin, cyfluthrin, permethrin, lambdacyhalothrin, ddt and malathion in filarial endemic areas of uttar pradesh, india. | 2011 | 21771692 |
| reduction in acute filariasis morbidity during a mass drug administration trial to eliminate lymphatic filariasis in papua new guinea. | acute painful swelling of the extremities and scrotum are debilitating clinical manifestations of wuchereria bancrofti infection. the ongoing global program to eliminate filariasis using mass drug administration is expected to decrease this and other forms of filarial morbidity in the future by preventing establishment of new infections as a consequence of eliminating transmission by the mosquito vector. we examined whether mass treatment with anti-filarial drugs has a more immediate health bene ... | 2011 | 21765964 |
| the impact of mass drug administration and long-lasting insecticidal net distribution on wuchereria bancrofti infection in humans and mosquitoes: an observational study in northern uganda. | abstract: background: lymphatic filariasis (lf) in uganda is caused by wuchereria bancrofti and transmitted by anopheline mosquitoes. the mainstay of elimination has been annual mass drug administration (mda) with ivermectin and albendazole, targeted to endemic districts, but has been sporadic and incomplete in coverage. vector control could potentially contribute to reducing w. bancrofti transmission, speeding up progress towards elimination. to establish whether the use of long-lasting insecti ... | 2011 | 21756371 |
| plasmodium falciparum and helminth coinfections among schoolchildren in relation to agro-ecosystems in mvomero district, tanzania. | in sub-saharan africa, some individuals infected with malaria are also infected with helminths. however, the magnitude and distribution of such coinfections in relation to eco-systems remains poorly defined. this study was undertaken to determine the prevalence of plasmodium falciparum and helminth coinfections among schoolchildren in relation to agro-ecosystems in mvomero district, tanzania. | 2011 | 21741929 |
| mapping of wuchereria bancrofti infection in children and adolescents in an endemic area of brazil. | a parasitological survey was conducted among children and adolescents in the municipality of jaboat+úo dos guararapes, brazil to describe the occurrence and spatial distribution of lymphatic filariasis. microfilaraemia was investigated through the thick smear technique, using 50++l of capillary blood that was collected at night. the spatial analysis used a digital base map of the municipality, divided into districts, which were classified as hypoendemic, mesoendemic or hyperendemic. 8670 childre ... | 2011 | 21726520 |
| filariasis in africa--treatment challenges and prospects. | lymphatic filariasis (lf) and onchocerciasis are parasitic nematode infections that are responsible for a major disease burden in the african continent. disease symptoms are induced by the immune reactions of the host, with lymphoedema and hydrocoele in lf, and dermatitis and ocular inflammation in onchocerciasis. wuchereria bancrofti and onchocerca volvulus, the species causing lf and onchocerciasis in africa, live in mutual symbiosis with wolbachia endobacteria, which cause a major part of the ... | 2011 | 21722251 |
| genital filariasis masquerading as testicular torsio. | 2011 | 21715738 | |
| prevalence of endemic bancroftian filariasis in the high altitude region of south-eastern nigeria. | the study was aimed at determining the prevalence and intensity of wuchereria bancrofti microfilaraemia in a high altitude region of south-eastern nigeria, and ascertaining the prevalence of clinical signs and symptoms associated with the filarial infections. | 2011 | 21715729 |
| microfilaria in liver aspiration cytology: an extremely rare finding. | filariasis is a common public health problem in the indian subcontinent. the diagnosis can be made conventionally by demonstrating microfilaria in peripheral blood smears. despite its high incidence it is unusual to find microfilariae in fine-needle aspiration (fna) cytology smears. microfilariae have been reported in cytological specimens of various organs, but it is extremely rare to find microfilaria in fine fna cytology of liver. we report seventh case of microfilaria in liver aspirate in a ... | 2011 | 21695804 |
| macrofilaricidal activity in wuchereria bancrofti after 2 weeks treatment with a combination of rifampicin plus doxycycline. | infection with the filarial nematode wuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis. since adult worms cause pathology in lymphatic filariasis (lf), it is imperative to discover macrofilaricidal drugs for the treatment of the infection. endosymbiotic wolbachia in filariae have emerged as a new target for antibiotics which can lead to macrofilaricidal effects. in ghana, a pilot study was carried out with 39 lf-infected men; 12 were treated with 200ôçëmg doxycycline/day ... | 2011 | 21687646 |
| clinical, parasitological and social studies on wuchereria bancrofti in egypt. | this study was conducted on patients attending al-hussein university hospital and mansura university hospitals. sheets were filled out on each patient (age, residence, occupation, family similar condition, travelling, disease duration, symptoms suggesting acute dermatolymphangitis attacks, frequency and duration. they were 25 lymphoedema patients and 8 controls (17 males & 16 females) and subjected to clinical and parasitological examinations. according to residence, five patients were from giza ... | 2011 | 21634252 |
| geographical distribution and relative abundance of culicine mosquitoes in relation to transmission of lymphatic filariasis in el menoufia governorate, egypt. | culicine mosquito were surveyed in el menoufia governorate (october to november 2008 and april to may 2009) in villages representing eight districts. six species were reported: culex (culex) pipiens linnaeus, cx. (cx) perexiguus theobald, cx. (cx.) antennatus (becker), aedes (ochlerotatus) caspius (pallas), aedes (ochlerotatus) detritus (haliday) and culiseta (allotheobaldia) longiareolata (macquart). cx. pipiens, the main filariasis vector was the commonest or predominating species (ca. 47% adu ... | 2011 | 21634247 |
| a laboratory-based surveillance system for wuchereria bancrofti in togo: a practical model for resource-poor settings. | abstract. one goal of the global program to eliminate lymphatic filariasis (gaelf) is interruption of disease transmission through annual mass drug administration (mda) in areas where lf prevalence is greater than 1%. after mdas are completed, the world health organization (who) recommends a period of passive surveillance before final certification of lf elimination is achieved. guidelines for such a surveillance system have yet to be developed. this paper describes a surveillance system launche ... | 2011 | 21633038 |
| stage-specific proteomic expression patterns of the human filarial parasite brugia malayi and its endosymbiont wolbachia. | global proteomic analyses of pathogens have thus far been limited to unicellular organisms (e.g., protozoa and bacteria). proteomic analyses of most eukaryotic pathogens (e.g., helminths) have been restricted to specific organs, specific stages, or secretomes. we report here a large-scale proteomic characterization of almost all the major mammalian stages of brugia malayi, a causative agent of lymphatic filariasis, resulting in the identification of more than 62% of the products predicted from t ... | 2011 | 21606368 |
| effect of annual mass administration of diethylcarbamazine and albendazole on bancroftian filariasis in five villages in south india. | annual mass drug administration (mda) is the recommended strategy for lymphatic filariasis (lf) elimination. we assessed the effect of six rounds of mass administration of diethylcarbamazine (dec) and albendazole (alb) on microfilaria (mf) prevalence and intensity and vector infection and infectivity rates and circulating filarial antigenaemia (cfa) in a group of five villages in south india, endemic for culex-transmitted bancroftian filariasis. during different rounds of mda, 60-70% of the elig ... | 2011 | 21601901 |
| influence of anti-filarial chemotherapy strategies on the genetic structure of wuchereria bancrofti populations. | lymphatic filarial (lf) parasites have been under anti-filarial drug pressure for more than half a century. currently, annual mass drug administration (mda) of diethylcarbamazine (dec) or ivermectin in combination with albendazole (alb) have been used globally to eliminate lf. long-term chemotherapies exert significant pressure on the genetic structure of parasitic populations. we investigated the genetic variation among 210 wuchereria bancrofti populations that were under three different chemot ... | 2011 | 21537687 |
| [mapping of lymphatic filariasis: "to be (in english) or not to be"]. | despite lack of supporting evidence from epidemiologic studies and/or confirmed case reports over the last 30 years, maps in non-specialist works on tropical medicine as well as in documents from specialized organizations (e.g. who) systematically include congo and gabon, two french-speaking countries, within the zone of endemic filariasis due to wuchereria bancrofti. one certainty is that no cases were found in field studies carried out in these countries in the late 1970s and 1980s but unfortu ... | 2010 | 21520639 |
| a rare case of reversible acquired aa-type renal amyloidosis in a chronic filariasis patient receiving antifilarial therapy. | lymphatic filariasis is a major health problem in india with a large number of patients tending to be asymptomatic. in the southeast and south asian regions, wuchereria bancrofti is the most prevalent parasite, causing filariasis in 99.4% of cases. while kidney involvement is a rare event in chronic filariasis, this case is unique because aa-type renal amyloidosis occurs in chronic w. bancrofti infection. we present here a unique case of lymphatic filariasis. the patient, a 25-year-old male who ... | 2011 | 21519822 |
| efficacy of home-based lymphoedema management in reducing acute attacks in subjects with lymphatic filariasis in burkina faso. | one of the two main goals of the global programme to eliminate lymphatic filariasis (lf) is to provide care for those suffering from the devastating clinical manifestations of this filarial infection. among the 120 million infected people worldwide, up to 16 million have lymphoedema. the who strategy for managing lymphoedema is based on rigorous skin hygiene, exercise, antibiotics and antifungals when indicated. the aim is to reduce acute attacks of adenolymphangitis and cellulitis responsible f ... | 2011 | 21470557 |
| towards novel antifilarial drugs: challenges and recent developments. | filariasis is caused by thread-like nematode worms, classified according to their presence in the vertebrate host. the cutaneous group includes onchocerca volvulus, loa loa and mansonella streptocerca; the lymphatic group includes wuchereria bancrofti, brugia malayi and brugia timori and the body cavity group includes mansonella perstans and mansonella ozzardi. lymphatic filariasis, a mosquito-borne disease, is one of the most prevalent diseases in tropical and subtropical countries and is accom ... | 2010 | 21426193 |
| tirandamycins from streptomyces sp. 17944 inhibiting the parasite brugia malayi asparagine trna synthetase. | lymphatic filariasis is caused by the parasitic nematodes brugia malayi and wuchereria bancrofti, and asparaginyl-trna synthetase (asnrs) is considered an excellent antifilarial target. the discovery of three new tirandamycins (tams), tam e (1), f (2), and g (3), along with tam a (4) and b (5), from streptomyces sp. 17944 was reported. remarkably, 5 selectively inhibits the b. malayi asnrs and efficiently kills the adult b. malayi parasite, representing a new lead scaffold to discover and develo ... | 2011 | 21405052 |
| filarial worms reduce plasmodium infectivity in mosquitoes. | co-occurrence of malaria and filarial worm parasites has been reported, but little is known about the interaction between filarial worm and malaria parasites with the same anopheles vector. herein, we present data evaluating the interaction between wuchereria bancrofti and anopheles punctulatus in papua new guinea (png). our field studies in png demonstrated that an. punctulatus utilizes the melanization immune response as a natural mechanism of filarial worm resistance against invading w. bancr ... | 2011 | 21347449 |
| description of the parasite wucheria bancrofti microfilariae identified in follicular fluid following transvaginal oocyte retrieval. | this case study presents an unusual finding of filarial infection within follicular fluid obtained during an in vitro fertilization (ivf) oocyte retrieval procedure. | 2011 | 21287402 |
| diurnally subperiodic filariasis in india-prospects of elimination: precept to action? | the elimination of lymphatic filariasis in the andaman and nicobar islands provides unique opportunities and challenges at the same time. since these islands are remote, are sparsely populated, and have poor transport networks, mass drug administration programs are likely to be difficult to implement. diurnally subperiodic wuchereria bancrofti vectored by downsiomyia nivea was considered for the scope of vector control options. considering the bioecology of this mosquito, vector control includin ... | 2011 | 21286754 |
| characterization of the dmae-modified juvenile excretory-secretory protein juv-p120 of litomosoides sigmodontis. | juv-p120 is an excretory-secretory 160 kda glycoprotein of juvenile female litomosoides sigmodontis and exhibits features typical for mucins. 50% of its molecular mass is attributed to posttranslational modifications with the unusual substituent dimethylaminoethanol (dmae). by that juv-p120 corresponds to the surface proteins of the microfilarial sheath, shp3 and shp3a. the secreted protein consists of 697 amino acids, organized in two different domains of repeat elements separated by a stretch ... | 2011 | 21241743 |
| bancroftian elephantiasis in nilphamari, bangladesh. | the parasitic nematodes wuchereria bancrofti, causes a dreadful disease in humans known as lymphatic filariasis, which afflicts more than 250 million people in tropical countries. twelve districts with about 20 million people are endemic out of 64 districts in bangladesh affecting more on northern districts. this study was done in the nilphamari, kisorgonj and sayedpur thana under nilphamari district, which is the most endemic for filariasis. in the present study, nineteen unions were investigat ... | 2011 | 21240161 |
| absence of lymphatic filariasis infection among secondary-school children in oman. | the endemicity status of lymphatic filariasis in oman is uncertain, with only sporadic cases reported, mostly imported. immunochromatographic card test surveys were carried out to assess the presence of circulating wuchereria bancrofti antigenaemia as a marker for active infection in children from suspected high-risk areas of oman (south batinah and dhofar). lot quality assurance sampling surveys were carried out on a minimum of 250 secondary-school children aged 17-18 years in each of 8 distric ... | 2010 | 21222423 |
| biochemical studies on glutathione s-transferase from the bovine filarial worm setaria digitata. | setaria digitata is a filarial worm of the cattle used as a model system for antifilarial drug screening, due to its similarity to the human filarial parasites wuchereria bancrofti and brugia malayi. since filarial glutathione s-transferase (gst) is a good biochemical target for antifilarial drug development, a study has been undertaken for the biochemical characterization of gst from s. digitata. cytosolic fraction was separated from the crude s.digitata worm homogenate by ultracentrifugation a ... | 2011 | 21207063 |
| lymphedema in a guyanan migrant. | 2010 | 21199149 | |
| first evidence of spatial clustering of lymphatic filariasis in an aedes polynesiensis endemic area. | successful elimination of lymphatic filariasis (lf) requires accurate identification of residual foci of transmission and stringent surveillance strategies to combat potential resurgence. this is challenging in areas where the day-biting aedes polynesiensis is endemic, such as samoa, since in previous studies no geographical clustering of infection has been demonstrated. another challenge for this low prevalence phase is the choice of diagnostic assay as testing for circulating filarial antigen ... | 2010 | 21172296 |
| a foray for filaria. | 2010 | 21143068 | |
| high prevalence of wuchereria bancrofti infection as detected by immunochromatographic card testing in five districts of orissa, india, previously considered to be non-endemic. | india accounts for over one-third of the world's burden of lymphatic filariasis (lf). although most coastal districts of orissa state (eastern india) are lf-endemic, the western districts of orissa are considered non-endemic. during a large-scale insecticide-treated bed net/microfinance trial, we tested one randomly selected adult (age 15-60 years) for lf from a random sample of microfinance-member households in five districts of western orissa, using immunochromatographic card testing (ict). ov ... | 2010 | 21122883 |
| incidental detection of filaria in fine-needle aspirates: a cytologic study of 14 clinically unsuspected cases at different sites. | filariasis is a major health problem in tropical countries like india. detection of microfilariae or adult worm or egg in fnac is very unusual despite the high incidence of this parasite in endemic zone. the aim of this study was to document the value of fine-needle aspiration cytology (fnac) in diagnosis of filaria at all possible sites presenting as mass or swelling.fourteen patients (nine males and five females) in the age range of 14-61 years were subjected to fnac. fna from swellings was do ... | 2010 | 21104843 |
| evaluation of synthetic peptides of wbsxp-1 for the diagnosis of human lymphatic filariasis. | parasitic nematodes infect nearly half of the world's human population, resulting in significant morbidity and mortality. though filariasis is not fatal, it is the second leading cause of permanent and long-term disability worldwide. filariasis has a spectrum of disease manifestation and infectivity found among the infected individuals and also goes unnoticed for years. furthermore, there are ample reports emerging on the genetic variation among the parasites population. hence, it is necessary t ... | 2010 | 21094425 |
| touchdown-touchup nested pcr for low-copy gene detection of benzimidazole-susceptible wuchereria bancrofti with a wolbachia endosymbiont imported by migrant carriers. | a novel, sensitive and specific touchdown-touchup nested pcr (tnpcr) technique based on two useful molecular markers, a wuchereria bancrofti β-tubulin gene involved in benzimidazole susceptibility and a wolbachia ftsz gene involved in cell division, was developed to simultaneously detect the parasite w. bancrofti (w1) with its wolbachia endosymbiont (w2) from both microfilaremic and post-treatment samples of at-risk migrant carriers infected with geographical w. bancrofti isolates. the detection ... | 2010 | 21074526 |
| a single dose of doxycycline in combination with diethylcarbamazine for treatment of bancroftian filariasis. | standard treatment of lymphatic filariasis with diethylcarbamazine (dec) is associated with systemic adverse reactions, thought to be due to the release of microfilariae material and wolbachia endosymbiotic bacteria into the blood. combination treatments with doxycycline for 3-8 weeks are more effective than standard treatment. however, long-term use of antibiotics may contribute to drug resistance and are not practical for use in remote areas. we assessed whether a single dose of doxycycline co ... | 2010 | 21073054 |
| midgut barrier imparts selective resistance to filarial worm infection in culex pipiens pipiens. | mosquitoes in the culex pipiens complex thrive in temperate and tropical regions worldwide, and serve as efficient vectors of bancroftian lymphatic filariasis (lf) caused by wuchereria bancrofti in asia, africa, the west indies, south america, and micronesia. however, members of this mosquito complex do not act as natural vectors for brugian lf caused by brugia malayi, or for the cat parasite b. pahangi, despite their presence in south asia where these parasites are endemic. previous work with t ... | 2010 | 21072236 |
| a note on anopheline vectors of wuchereria bancrofti in west africa. | 1946 | 21066379 | |
| adult filarial worm by fine needle aspiration cytology of breast lumps. | 2010 | 21053616 | |
| higher-dose, more frequent treatment of wuchereria bancrofti. | 2010 | 21039221 | |
| use of high-dose, twice-yearly albendazole and ivermectin to suppress wuchereria bancrofti microfilarial levels. | annual mass treatment with albendazole and ivermectin is the mainstay of current strategies to interrupt transmission of wuchereria bancrofti in africa. more-effective microfilarial suppression could potentially reduce the time necessary to interrupt transmission, easing the economic burden of mass treatment programs in countries with limited resources. | 2010 | 21039220 |
| studies on filariasis; potential mosquito vectors of wuchereria bancrofti. | 1946 | 21020565 | |
| observations on two cases of human filariasis (wuchereria bancrofti and mansonella ozzardi). | 1946 | 21019186 | |
| studies on filariasis; serological relationships between antigenic extracts of wuchereria bancrofti and dirofilaria immitis. | 1946 | 21018330 | |
| chemotherapy of filariasis due to wuchereria bancrofti with neostibosan. | 1946 | 21018328 | |
| observations on the incidence of wuchereria bancrofti larvae in the native population of the solomon islands area. | 1945 | 21010816 | |
| observations on the specificity and clinical use of dirofilaria immitis antigen in the diagnosis of human filariasis (wuchereria bancrofti). | 1946 | 21009777 | |
| tropical diseases with special reference to filariasis (wuchereria bancrofti). | 1945 | 21003947 | |
| studies of filariasis; development of wuchereria bancrofti in culex quinquefasciatus of oahu. | 1946 | 21003277 | |
| experiments to determine potential mosquito vectors of wuchereria bancrofti in the continental united states, part 2. | 1946 | 21003276 | |
| the migration of infective larvae of wuchereria bancrofti within the mosquito host and their rate of escape under laboratory conditions. | 1946 | 20990871 | |
| toward molecular parasitologic diagnosis: enhanced diagnostic sensitivity for filarial infections in mobile populations. | the diagnosis of filarial infections among individuals residing in areas where the disease is not endemic requires both strong clinical suspicion and expert training in infrequently practiced parasitological methods. recently developed filarial molecular diagnostic assays are highly sensitive and specific but have limited availability and have not been closely evaluated for clinical use outside populations residing in areas of endemicity. in this study, we assessed the performance of a panel of ... | 2010 | 20980560 |
| microfilaria in malignant pleural effusion: an unusual association. | lymphatic filariasis is common in tropical countries and is endemic in india. filariasis presenting with pleural effusion is an unusual presentation. malignancy in association of filarial pleural effusion is extremely rare. we report a case of a 60-year-old female who presented with chest pain, loss of weight and breathlessness for a few months. pleural fluid examination revealed malignant cells, along with microfilaria of wuchereria bancrofti. | 2010 | 20966579 |
| expanded numbers of circulating myeloid dendritic cells in patent human filarial infection reflect lower ccr1 expression. | apc dysfunction has been postulated to mediate some of the parasite-specific t cell unresponsiveness seen in patent filarial infection. we have shown that live microfilariae of brugia malayi induce caspase-dependent apoptosis in human monocyte-derived dendritic cells (dcs) in vitro. this study addresses whether apoptosis observed in vitro extends to patent filarial infections in humans and is reflected in the number of circulating myeloid dcs (mdcs; cd11c(-)cd123(lo)) in peripheral blood of infe ... | 2010 | 20956349 |
| [filaria]. | 2010 | 20942062 | |
| evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of wuchereria bancrofti infection using multiple infection parameters. | objectives: to evaluate the effect of multiple rounds of annual single dose of dec (6mg/kg) or albendazole (400mg) given alone or in combination on wuchereria bancrofti microfilaraemia, anti-filarial igg1 and igg4 and antigenaemia. methods: a total of 170 participants were randomly assigned to albendazole (n=62), dec (n=54), and dec plus albendazole (dec/alb) combination (n=54). blood samples were collected at pre-treatment in 1998, at 1 week and 6 months after the first treatment and thereafter ... | 2010 | 20933491 |
| improving community participation to eliminate lymphatic filariasis in american samoa. | in 2000, the american samoa department of health initiated a campaign of annual mass drug administration (mda) with albendazole and diethylcarbamazine (dec) to eliminate transmission of filariasis. drug coverage was well below prescribed targets in the first three campaigns, ranging from 24 to 52% of the total population. evaluation findings from a variety of formative research methods identified opportunities to improve mda coverage and ensuing program modifications resulted in increased drug c ... | 2010 | 20932818 |
| pathogenomics of culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens. | the mosquito culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of west nile virus (wnv), the filarial worm wuchereria bancrofti, and an avian malaria parasite. comparative phylogenomics revealed an expanded canonical c. quinquefasciatus immune gene repertoire compared with those of aedes aegypti and anopheles gambiae. transcriptomic analysis of c. quinquefasciatus genes responsive to wnv, w. bancrofti, and non-native bacteria facilitated an unpr ... | 2010 | 20929811 |
| effect of a single dose of diethylcarbamazine, albendazole or both on the clearance of wuchereria bancrofti microfilariae and antigenaemia among microfilaria carriers: a randomized trial. | lymphatic filariasis is a major vector-borne parasitic disease. the global programme to eliminate lymphatic filariasis was launched in 1997 and currently over 570 million people are covered under it in 48 countries. mass annual single-dose drug administration of diethylcarbamazine (dec), co-administrated with albendazole for 5-6 years and mass distribution of diethylcarbamazine-fortified salt are the two strategies for elimination of filariasis. | 2010 | 20925201 |
| up-regulation of lipophorin (lp) and lipophorin receptor (lpr) gene in the mosquito, culex quinquefasciatus (diptera: culicidae), infected with the filarial parasite, wuchereria bancrofti (spirurida: onchocercidae). | in mosquitoes, including culex quinquefasciatus, immune molecules are known to be upregulated or produced de novo upon exposure to parasites or pathogens. these molecules are regulatory in nature acting against parasite or pathogen infection and development. similarly, there are molecules that are upregulated to facilitate parasite development in the vector mosquitoes. lipophorin, a major lipid transporting lipoprotein in the hemolymph of insects, is implicated as a helper molecule in the clotti ... | 2010 | 20922426 |
| elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections. | lymphatic dilatation, dysfunction, and lymphangiogenesis are hallmarks of patent lymphatic filariasis, observed even in those with subclinical microfilaremia, through processes associated, in part, by vascular endothelial growth factors (vegfs). a panel of pro-angiogenic factors was measured in the plasma of subjects from filaria-endemic regions using multiplexed immunological assays. compared with endemic normal control subjects, those with both subclinical microfilaremia, and those with longst ... | 2010 | 20889885 |
| filarial labial chylorrhoea: an uncommon problem in an endemic region. | 2010 | 20845300 | |
| post-kidney transplantation lymphocele due to a lymphatic filariasis. | lymphocele is a well-known complication of renal transplantation. presenting symptoms are nonspecific; most patients are entirely asymptomatic. herein, we have reported a case of lymphocele due to an asymptomatic lymphatic wuchereria bancrofti filariasis with deterioration of graft function. a 53-year-old man with end-stage renal disease secondary to vascular disease was admitted 40 days after transplantation with vague, isolated abdominal pain. an abdomen and pelvis ultrasound examination demon ... | 2010 | 20832594 |
| crucial epitopes of wuchereria bancrofti abundant larval transcript recognized in natural infection. | lymphatic filariasis is a tropical disease, with over 40 million people seriously incapacitated due to lymphangitis and elephantiasis. over 99% of infections are caused by the nematode wuchereria bancrofti. expressed sequence tag (est) analysis of filarial genome identified novel infective larval (l3) stage-specific antigen, abundant larval transcript (alt-2), which was shown to be highly essential for parasite establishment and survival in the host. the unique structural features and immunologi ... | 2010 | 20803227 |
| lymphatic filariasis in india: epidemiology and control measures. | lymphatic filariasis caused by wuchereria bancrofti and brugia malayi is an important public health problem in india. both parasites produce essentially similar clinical presentations in man, related mainly to the pathology of the lymphatic system. filariasis is endemic in 17 states and six union territories, with about 553 million people at risk of infection. the government of india has accorded a high priority for elimination of this infection through mass chemotherapy programme (annual, singl ... | 2010 | 20739779 |
| evidence for the exacerbation of lymphedema of geochemical origin, podoconiosis, by onchocerciasis. | the study was conducted to investigate a variation in the distribution of endemic elephantiasis previously determined to be of geochemical origin in three neighbouring and essentially homogenous villages, bambili, bambui and finge of the bambui health district of nw cameroon. a total of 301 subjects were examined for onchocerciasis and lymphatic filariasis in the area using standard procedures. the onchocercal microfilarial prevalence varied from 6.5% in bambili through 20.4% in bambui to 60.4% ... | 2009 | 20701883 |
| the role of ultrasonography in the differentiation of the various types of filaricele due to bancroftian filariasis. | objective: (i) to determine the frequencies of urogenital pathologies in men infected with bancroftian filariasis, and (ii) to evaluate the role of ultrasonography (usg) as a diagnostic tool to differentiate between diverse pathologies with different clinical implications. to date, all types of scrotal enlargement resulting from lymphatic filariasis (lf) have been summarized under one term: "filaricele". patients and methods: data were compiled from recruitment phases for field trials in an ende ... | 2010 | 20673752 |
| vector transmission heterogeneity and the population dynamics and control of lymphatic filariasis. | a long-standing gap in lymphatic filariasis epidemiology is quantifying the potential effect that heterogeneous infection processes occurring in the major mosquito vector genera may have on parasite transmission and control. although previous studies have focussed on examining the forms of the density dependent mechanisms regulating larval infection in various mosquito genera, there has been little work done thus far in investigating how such differential processes might interact with density-de ... | 2010 | 20632527 |
| elimination of lymphatic filariasis in southeast asia. | approximately 15 million people with lymphatic filariasis (lf) live in southeast asia. wuchereria bancrofti (transmitted by the mansonia and anopheles vectors), brugia malayi and brugia timori (both transmitted by culex quinquefasciatus) are the filarial species in this region. the endemic countries are: cambodia, lao people's democratic republic, the philippines, indonesia, thailand and timor-leste, which have all agreed to eliminate transmission of the disease by 2020. the public health interv ... | 2010 | 20624533 |
| detection and discrimination of loa loa, mansonella perstans and wuchereria bancrofti by pcr-rflp and nested-pcr of ribosomal dna its1 region. | the ribosomal deoxyribonucleic acid (dna) internal transcribed spacer region (its1) of two filarial nematodes, loa loa and mansonella perstans, was amplified and further sequenced to develop an species-specific polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) protocol for the differentiation of both species from wuchereria bancrofti, three filarial nematodes with blood circulating microfilariae. the its1-pcr product digested with the restriction endonuclease ase i ge ... | 2011 | 20599994 |
| the bacteria wolbachia in filariae, a biological russian dolls' system: new trends in antifilarial treatments. | filarial nematode species can host wolbachia bacterial endosymbionts. to understand the symbiosis, a higher level of complexity should be considered, taking in account the tripartite association between wolbachia, filariae and mammals. this overview article discusses the biology of wolbachia in filariae, including their distribution and phylogeny, mechanisms of action, inflammatory consequences on mammal host and biological control implications for filariases. potential directions for future res ... | 2010 | 20597434 |
| size and charge antigens of dirofilaria immitis adult worm for igg-elisa diagnosis of bancroftian filariasis. | we used dirofilaria immitis adult worm antigens to develop an igg-elisa, then used this to evaluate 30 serum samples of patients with proven wuchereria bancrofti infection, 131 samples of patients with other parasitic diseases and 30 serum samples of healthy controls. the d. immitis antigen was prepared using two methods: sephacryl s-200 chromatography and iso-electric focusing with a rotofor cell. this was done to determine the best method for diagnosing w. bancrofti filariasis. before fraction ... | 2010 | 20578510 |
| assessment of family and neighbors of an individual infected with wuchereria bancrofti from a non-endemic area in the city of maceió, brazil. | the family and neighbors of a patient infected with w. bancrofti microfilariae were assessed aiming to evaluate the occurrence of cases of lymphatic filariasis in a non-endemic area in the city of maceió, in the brazilian state of alagoas. the patient had previously lived in an endemic focus; however, he has been living in an area where the parasite has never been detected for the past ten years. female ingurgitated culex quinquefasciatus mosquitoes captured in the houses of the microfilaremic i ... | 2010 | 20563436 |
| lymphatic filariasis in children: age dependent prevalence in an area of india endemic for wuchereria bancrofti infection. | lymphatic filariasis has been considered as a disease of adults and most epidemiological surveys have excluded children. the prevalence of infection and clinical manifestations of the disease among children in the age group of 1-15 years was determined in a wuchereria bancrofti endemic area. the 1383 children from the rural villages of a coastal district (khurda), state of orissa, india, were studied. the finger prick blood (50ìl) samples were collected between 20:30 and 23:30 hours for parasito ... | 2010 | 20562812 |
| association between toll-like receptor 2 (tlr2) polymorphisms and asymptomatic bancroftian filariasis. | lymphatic filariasis is mainly caused by the filarial nematodes wuchereria bancrofti and brugia malayi. wolbachia, intracellular symbiotic bacteria in filarial parasite, is known to induce immune response predominantly through toll-like receptor 2 (tlr2). this study was performed to investigate the association between polymorphisms of the tlr2 gene and susceptibility to asymptomatic bancroftian filariasis. a total of 142 unrelated asymptomatic bancroftian filariasis patients and 151 endemic norm ... | 2010 | 20549240 |
| bancroftian filariasis among the mbembe people of cross river state, nigeria. | bancroftian filariasis is a major public health and socioeconomic problems in the humid tropical and subtropical regions of the world. a study was undertaken to investigate the status of the disease in some rural communities of cross river state, nigeria, with a view to enriching the epidemiological baseline data of the disease in nigeria. | 2010 | 20539046 |