Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| polymerase chain reaction as a diagnostic tool for six sexually transmitted infections - preliminary results. | sexually transmitted infections are a very frequent and under-diagnosed cause of illness worldwide. a high number of detection methods and a large range of specimens in which sexually transmitted infections can be determined are available at the moment. polymerase chain reaction performed on first void urine offers the advantage of being non-invasive, self-collectable and has high sensitivity and specificity. we looked to determine the frequency of chlamydia trachomatis, neisseria gonorrhoeae, t ... | 2015 | 26528045 |
| in vitro trichomonacidal activity and preliminary in silico chemometric studies of 5-nitroindazolin-3-one and 3-alkoxy-5-nitroindazole derivatives. | a selection of 1,2-disubstituted 5-nitroindazolin-3-ones (1-19) and 3-alkoxy-5-nitroindazoles substituted at positions 1 (20-24) or 2 (25-39) from our in-house compound library were screened in vitro against the most common curable sexually transmitted pathogen, trichomonas vaginalis. a total of 41% of the studied molecules (16/39) achieved a significant activity of more than 85% growth inhibition at the highest concentration assayed (100 µg ml(-1)). among these compounds, 3-alkoxy-5-nitroindazo ... | 2016 | 26525913 |
| experience of successful treatment of patients with metronidazole-resistant trichomonas vaginalis with zinc sulfate: a case series. | there are no universally successful guidelines for the treatment of metronidazole-resistant vaginal trichomoniasis. this is distressing for patients and frustrating for physicians. we therefore decided to evaluate whether zinc sulfate douche is effective in treating vaginal trichomoniasis, because the compound is a natural antimicrobial chemical defense in humans. | 2015 | 26522122 |
| modulatory effect of iron chelators on adenosine deaminase activity and gene expression in trichomonas vaginalis. | trichomonas vaginalis is a flagellate protozoan that parasitises the urogenital human tract and causes trichomoniasis. during the infection, the acquisition of nutrients, such as iron and purine and pyrimidine nucleosides, is essential for the survival of the parasite. the enzymes for purinergic signalling, including adenosine deaminase (ada), which degrades adenosine to inosine, have been characterised in t. vaginalis. in the evaluation of the ada profile in different t. vaginalis isolates trea ... | 2015 | 26517498 |
| microbiological characteristics of chlamydia trachomatis and neisseria gonorrhoeae infections in south african women. | we analyzed data of 263 women with at least one genital or anorectal sexually transmitted infection from a cross-sectional study conducted in rural south africa. we provide new insights concerning the concurrence of chlamydia trachomatis, neisseria gonorrhoeae, mycoplasma genitalium, and trichomonas vaginalis infections as well as the characteristics of bacterial loads. | 2015 | 26511740 |
| alcohol use problems and sexual risk among young adult african american mothers. | studies have documented high levels of alcohol use and sexual risk among young mothers. we examined parenting satisfaction and self-efficacy in relation to alcohol use problems and sexual risk among 346 young african american women enrolled in an hiv prevention trial, 41 % (n = 141) of whom were mothers. among mothers, greater parenting satisfaction was associated with a reduced likelihood of problematic alcohol use, having multiple sex partners, and testing positive for trichomonas vaginalis. r ... | 2016 | 26499334 |
| clinical and laboratory testing for trichomonas vaginalis infection. | trichomonas vaginalis infection is highly prevalent in the united states and worldwide. traditional clinical diagnostic methods fail to identify more than half of these infections that, if left untreated, can result in adverse pregnancy outcomes and an exacerbated risk of both acquisition and transmission of hiv. women bear a disproportionate amount of the burden of these infections, and testing among populations at risk for this disease should be provided. molecular technologies have expanded o ... | 2015 | 26491181 |
| genital infections and risk of premature rupture of membranes in mulago hospital, uganda: a case control study. | inflammatory mediators that weaken and cause membrane rupture are released during the course of genital infections among pregnant women. we set out to determine the association of common genital infections (trichomonas vaginalis, syphilis, neisseria gonorrhea, chlamydia trachomatis, group b streptococcus, bacterial vaginosis, herpes simplex virus type 2 and candidiasis) and premature rupture of membranes in mulago hospital, uganda. | 2015 | 26475265 |
| n-terminal presequence-independent import of phosphofructokinase into hydrogenosomes of trichomonas vaginalis. | mitochondrial evolution entailed the origin of protein import machinery that allows nuclear-encoded proteins to be targeted to the organelle, as well as the origin of cleavable n-terminal targeting sequences (nts) that allow efficient sorting and import of matrix proteins. in hydrogenosomes and mitosomes, reduced forms of mitochondria with reduced proteomes, nts-independent targeting of matrix proteins is known. here, we studied the cellular localization of two glycolytic enzymes in the anaerobi ... | 2015 | 26475173 |
| detection and molecular characterization of double-stranded rna viruses in philippine trichomonas vaginalis isolates. | the flagellated protozoon trichomonas vaginalis that parasitizes the urogenital tract of humans was reported to harbor double-stranded rna (dsrna) viruses. these viruses, identified as trichomonas vaginalis virus (tvv), belong to the genus trichomonasvirus of the family totiviridae. four species, formally recognized by the international committee on taxonomy of viruses (ictv), have been reported and distinguished by pairwise comparisons of the sequences of genes coding for major capsid protein ( ... | 2015 | 26471924 |
| trichomonas vaginalis erythrophagocytosis in the urine sediment. | 2016 | 26468272 | |
| patient-delivered partner treatment for chlamydia, gonorrhea, and trichomonas infection among pregnant and postpartum women in kenya. | patient-delivered partner treatment (pdpt) for sexually transmitted infections (stis) increases rates of partner treatment and decreases reinfection, but has not been evaluated during pregnancy. | 2015 | 26462189 |
| trichomonas vaginalis infection in nigerian pregnant women and risk factors associated with sexually transmitted infections. | trichomoniasis poses a public health threat to pregnant women and neonatal health. this study evaluated trichomonas vaginalis and other common sexually transmitted infections (stis) status in pregnant women, and risk factors associated with them. the study was cross-sectional and descriptive and a total of 198 pregnant women were recruited for t. vaginalis screening by microscopic examination. questionnaires were also administered to 108 pregnant women to access information related to socio-demo ... | 2016 | 26438604 |
| a scottish multi-centre service evaluation examining the prevalence and diagnosis of trichomonas vaginalis in symptomatic women attending sexual health clinics. | trichomoniasis caused by the protozoan parasite trichomonas vaginalis (tv) is one of the most commonly occurring sexually transmitted infections of non-viral origin. this study examines the prevalence of tv infection amongst consenting symptomatic women attending three of the largest sexual health clinics in scotland, united kingdom. in addition, an evaluation of three testing methods to identify tv from vaginal fluid was performed involving the commercial hologic aptima tv transcription-mediate ... | 2016 | 26429895 |
| comparative aspects of immunity and vaccination in human and bovine trichomoniasis: a review. | trichomonas vaginalis and tritrichomonas foetus are important extracellular protozoans that cause, respectively, human and bovine venereal diseases. trichomonads are extracellular parasites that primarily inhabit the genital tracts of the mammalian hosts where they overcome the mucus barrier and parasitize mucosa by contact-dependent or contact-independent cytotoxicity. transient immunity is usually achieved by the host after clinical infection. at present, vaccination in cattle reduces infectio ... | 2016 | 26424377 |
| digestion of glycogen by a glucosidase released by trichomonas vaginalis. | trichomonas vaginalis is a protozoan parasite that is the causative agent of trichomoniasis, a widespread sexually transmitted disease. in vitro culture of t. vaginalis typically employs a medium supplemented with either maltose or glucose and carbohydrates are considered essential for growth. although the nature of the carbohydrates utilized by t. vaginalis in vivo is undefined, the vaginal epithelium is rich in glycogen, which appears to provide a source of carbon for the vaginal microbiota. h ... | 2015 | 26420465 |
| bifunctional activity of deoxyhypusine synthase/hydroxylase from trichomonas vaginalis. | the trichomonas vaginalis genome analysis suggested the presence of a putative deoxyhypusine synthase (tvdhs) that catalyzes the posttranslational modification of eif-5a. herein, we expressed and purified the recombinant tvdhs (rtvdhs) protein (43 kda) and the recombinant tveif-5a (rtveif-5a) precursor protein (46 kda). a 41 kda band of the native tvdhs was recognized by western blot analysis in t. vaginalis total protein extract by a mouse polyclonal anti-rtvdhs antibody. the enzymatic activity ... | 2016 | 26410361 |
| comparison of cervico-vaginal colonization among sexually active women by intrauterine device use. | in this study we aimed to evaluate the effect of intrauterine devices (iuds) on cervico-vaginal colonization. | 2015 | 26409733 |
| optimal reference genes for gene expression normalization in trichomonas vaginalis. | trichomonas vaginalis is the etiologic agent of trichomonosis, the most common non-viral sexually transmitted disease worldwide. this infection is associated with several health consequences, including cervical and prostate cancers and hiv acquisition. gene expression analysis has been facilitated because of available genome sequences and large-scale transcriptomes in t. vaginalis, particularly using quantitative real-time polymerase chain reaction (qrt-pcr), one of the most used methods for mol ... | 2015 | 26393928 |
| a case of metronidazole-resistant trichomonas vaginalis in pregnancy. | trichomonas vaginalis is a sexually transmitted protozoan infection resulting in vulvo-vaginitis and altered vaginal discharge in symptomatic women. trichomoniasis has been implicated in causing adverse pregnancy outcomes such as low birth weight and pre-term labour. metronidazole is the recommended first-line treatment for trichomonal infection. other nitroimidazoles, such as tinidazole, are used as alternative regimens with similar activity but at a greater expense. treatment failure usually r ... | 2016 | 26384945 |
| trichomonas vaginalis infection among homeless and unstably housed adult women living in a resource-rich urban environment. | the social context of poverty is consistently linked to trichomonas vaginalis infection, yet few studies regarding t. vaginalis have been conducted exclusively among low-income individuals. we identified social determinants of health associated with prevalent t. vaginalis infection among homeless and unstably housed adult women. | 2016 | 26347544 |
| in vitro anti-trichomonas vaginalis activity of pistacia lentiscus mastic and ocimum basilicum essential oil. | trichomonas vaginalis is a protozoan parasite that causes trichomoniasis; a cosmopolitan sexually transmitted disease. metronidazole is the drug of choice for t. vaginalis infections. the increase in metronidazole resistant parasites and undesirable side effects of this drug makes the search for an alternative a priority for the management of trichomoniasis. pistacia lentiscus mastic and ocimum basilicum oil are known for their antibacterial, antifungal, antiviral and antiprotozoal effects. the ... | 2015 | 26345053 |
| conservation of transit peptide-independent protein import into the mitochondrial and hydrogenosomal matrix. | the origin of protein import was a key step in the endosymbiotic acquisition of mitochondria. though the main translocon of the mitochondrial outer membrane, tom40, is ubiquitous among organelles of mitochondrial ancestry, the transit peptides, or n-terminal targeting sequences (ntss), recognised by the tom complex, are not. to better understand the nature of evolutionary conservation in mitochondrial protein import, we investigated the targeting behavior of trichomonas vaginalis hydrogenosomal ... | 2015 | 26338186 |
| eicosapentaenoic acid modulates trichomonas vaginalis activity. | trichomonas vaginalis is a sexually transmitted parasite and, while it is often asymptomatic in males, the parasite is associated with disease in both sexes. metronidazole is an effective treatment for trichomoniasis, but resistant strains have evolved and, thus, it has become necessary to investigate other possible therapies. in this study, we examined the effects of native and oxidized forms of the sodium salts of eicosapentaenoic, docosahexaenoic, and arachidonic acids on t. vaginalis activit ... | 2016 | 26333486 |
| the contribution of cervicovaginal infections to the immunomodulatory effects of hormonal contraception. | particular types of hormonal contraceptives (hcs) and genital tract infections have been independently associated with risk of hiv-1 acquisition. we examined whether immunity in women using injectable depot medroxyprogesterone acetate (dmpa), combined oral contraceptives (coc), or no hcs differs by the presence of cervicovaginal infections. immune mediators were quantified in cervical swabs from 832 hiv-uninfected reproductive-age ugandans and zimbabweans. bacterial infections and hiv were diagn ... | 2015 | 26330510 |
| involvement of pi3k/akt and mapk pathways for tnf-α production in siha cervical mucosal epithelial cells infected with trichomonas vaginalis. | trichomonas vaginalis; induces proinflammation in cervicovaginal mucosal epithelium. to investigate the signaling pathways in tnf-α production in cervical mucosal epithelium after t. vaginalis infection, the phosphorylation of pi3k/akt and mapk pathways were evaluated in t. vaginalis-infected siha cells in the presence and absence of specific inhibitors. t. vaginalis increased tnf-α production in siha cells, in a parasite burden-dependent and incubation time-dependent manner. in t. vaginalis-inf ... | 2015 | 26323834 |
| prevalence of trichomoniasis, vaginal candidiasis, genital herpes, chlamydiasis, and actinomycosis among urban and rural women of haryana, india. | despite being curable reproductive tract infections (rtis) including sexually transmitted infections continue to be a major health problem in developing countries. the present study was undertaken to know the prevalence of trichomoniasis, vaginal candidiasis, genital herpes, chlamydiasis, and actinomycosis in rural and urban women of haryana by using wet mount, pap smear, and fluorescent microscopic examination. patients suspected of suffering from bacterial vaginosis were given treatment and we ... | 2014 | 26316979 |
| trichomonas vaginalis incidence associated with hormonal contraceptive use and hiv infection among women in rakai, uganda. | background. data on the incidence of trichomonas vaginalis and use of hormonal contraception (hc) are limited. methods. 2,374 sexually active women aged 15-49 years from cohort surveys in rakai, uganda, were included. incidence of t. vaginalis was estimated per 100 person years (py) and association between hc (dmpa, norplant, and oral contraceptives) and t. vaginalis infection was assessed by incidence rate ratios (irr), using poisson regression models. results. at baseline, 34.9% had used hc in ... | 2014 | 26316977 |
| sexually transmitted infections in women participating in a biomedical intervention trial in durban: prevalence, coinfections, and risk factors. | background. sexually transmitted infections (stis) continue to be a significant public health problem especially among women of reproductive age in africa. methods. a total of 2236 women that had enrolled in the mdp301 vaginal microbicide trial were tested for the presence of chlamydia trachomatis (ct), neisseria gonorrhea (ng), treponema pallidum, and trichomonas vaginalis (tv). results. ct was identified as the most prevalent sti (11%) followed by tv (10%), ng, and syphilis (3%). the highest p ... | 2013 | 26316957 |
| comparative inhibition study of compounds identified in the methanolic extract of apamarga kshara against trichomonas vaginalis carbamate kinase (tvck): an enzoinformatics approach. | in the present study, we have identified ten compounds, namely dodecanol acid, myristic acid, neophytadiene, palmitic acid, heptadecanoic acid, linoleic acid, elaidic acid, 3-7-dimethyl acid, stearic acid and methyl eicos acid, of the methanolic extract of apamarga kshara by gc-ms analysis. apamarga kshara has been reported to be active against cervical erosion. major causal organism for cervical erosion is trichomonas vaginalis. however, there is a paucity of information about the mechanism of ... | 2016 | 26310620 |
| stop codon recognition in the early-diverged protozoans giardia lamblia and trichomonas vaginalis. | two classes of polypeptide release factors (rfs) are responsible for maintaining accuracy in translation termination; however, their detailed mechanism of action and evolutionary history of these factors remain elusive. the structure and function of rfs vary in bacteria and eukaryotes, a fact that is suggestive of evolutionary changes in the translation termination system. giardia lamblia (diplomonada) and trichomonas vaginalis (parabasalia) are considered as early-diverged eukaryotes. the class ... | 2015 | 26310515 |
| novel insights into the molecular events linking to cell death induced by tetracycline in the amitochondriate protozoan trichomonas vaginalis. | trichomonas vaginalis colonizes the human urogenital tract and causes trichomoniasis, the most common nonviral sexually transmitted disease. currently, 5-nitroimidazoles are the only recommended drugs for treating trichomoniasis. however, increased resistance of the parasite to 5-nitroimidazoles has emerged as a highly problematic public health issue. hence, it is essential to identify alternative chemotherapeutic agents against refractory trichomoniasis. tetracycline (tet) is a broad-spectrum a ... | 2015 | 26303799 |
| structure-based design of inhibitors of the crucial cysteine biosynthetic pathway enzyme o-acetyl serine sulfhydrylase. | the cysteine biosynthetic pathway is of fundamental importance for the growth, survival, and pathogenicity of the many pathogens. this pathway is present in many species but is absent in mammals. the ability of pathogens to counteract the oxidative defences of a host is critical for the survival of these pathogens during their long latent phases, especially in anaerobic pathogens such as entamoeba histolytica, leishmania donovani, trichomonas vaginalis, and salmonella typhimurium. all of these o ... | 2016 | 26303427 |
| relationship between female genital tract infections, mucosal interleukin-17 production and local t helper type 17 cells. | t helper type 17 (th17) cells play an important role in immunity to fungal and bacterial pathogens, although their role in the female genital tract, where exposure to these pathogens is common, is not well understood. we investigated the relationship between female genital tract infections, cervicovaginal interleukin-17 (il-17) concentrations and th17 cell frequencies. forty-two cytokines were measured in cervicovaginal lavages from hiv-uninfected and hiv-infected women. frequencies of th17 cell ... | 2015 | 26302175 |
| evaluation of the new amplisens multiplex real-time pcr assay for simultaneous detection of neisseria gonorrhoeae, chlamydia trachomatis, mycoplasma genitalium, and trichomonas vaginalis. | in this study, we performed an evaluation of the new ce-marked multiplex real-time amplisens n.gonorrhoeae/c.trachomatis/m.genitalium/t.vaginalis-multiprime-frt pcr assay compared to aptima tests, i.e., aptima combo 2 assay, aptima trichomonas vaginalis assay (fda-approved), and two different aptima mycoplasma genitalium assays (research use only; one of them only used for discrepancy analysis). vaginal swabs (n = 209) and first-void urine (fvu) specimens from females (n = 498) and males (n = 55 ... | 2015 | 26299582 |
| anaerobic respiration: in vitro efficacy of nitazoxanide against mitochondriate acanthamoeba castellanii of the t4 genotype. | acanthamoeba is an opportunistic protist pathogen that is responsible for serious human and animal infection. being one of the most frequently isolated protists from the environment, it is likely that it readily encounters microaerophilic environments. for respiration under anaerobic or low oxygen conditions in several amitochondriate protists, decarboxylation of pyruvate is catalyzed by pyruvate ferredoxin oxidoreductase instead of pyruvate dehydrogenase. in support, nitazoxanide, an inhibitor ... | 2015 | 26297676 |
| prevalence of vulvovaginitis and relation to physical findings in girls assessed for suspected child sexual abuse. | the presence of sexually transmitted infections (stis) in patients with suspected sexual abuse is uncommon in the field of pediatrics. | 2015 | 26294142 |
| use of a risk quiz to predict infection for sexually transmitted infections: a retrospective analysis of acceptability and positivity. | individuals who are sexually active may want to make a decision as to whether they are at risk for having a sexually transmitted infection (sti) such as chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis. our goal was to develop and evaluate a simple self-taken sexual risk quiz for participants, ordering an online sti self-collection test kit to determine whether the score predicted infection status. | 2015 | 26285773 |
| trichomonas vaginalis and mycoplasma genitalium: age-specific prevalence and disease burden in men attending a sexually transmitted infections clinic in amsterdam, the netherlands. | men are not routinely tested for trichomonas vaginalis (tv) and mycoplasma genitalium (mg) in the netherlands and, therefore, very few studies have looked into their prevalence and/or role in urogenital complaints in the dutch male population. | 2016 | 26283740 |
| distribution of human papillomavirus (hpv) genotypes and bacterial vaginosis presence in cervical samples from paraguayan indigenous. | to determine the frequency of human papillomavirus (hpv) types and to assess bacterial vaginosis (bv) possible associations with cervical infections in indigenous paraguayan women of the department of presidente hayes. | 2015 | 26283550 |
| prevalence of and risk factors for bacterial vaginosis among women of reproductive age attending cervical screening in southeastern brazil. | to determine the prevalence of and risk factors for bacterial vaginosis. | 2015 | 26283224 |
| prevalence of microorganisms co-infections in human papillomaviruses infected women in northern china. | due to scarce data on the prevalence of genital microorganism infections among individuals with human papillomavirus (hpv) infections, the present study aimed to evaluate microorganism co-infections and associated risk factors in hpv-infected women in northern china. | 2016 | 26280325 |
| sexually transmitted pathogens, depression, and other manifestations associated with premenstrual syndrome. | this study investigated whether sexually transmitted infections and lifestyle variables are associated with premenstrual syndrome (pms) as well as particular manifestations commonly associated with pms. data were gathered from medical records of 500 regularly cycling women. the following infectious agents were investigated: human papillomavirus, chlamydia trachomatis, neisseria gonorrheae, gardnerella vaginalis, candida albicans, and trichomonas vaginalis. bivariate tests and multivariate logist ... | 2015 | 26272230 |
| trichomonas vaginalis infection in a tertiary care vaginitis center. | trichomonas vaginalis infection (tvi) is one of the most common sexually transmitted diseases in the united states. we sought to determine the features of tvi in a referral-based vaginitis center, focusing on diagnosis and treatment of difficult cases. | 2015 | 26267873 |
| comparison of the effect of vaginal zataria multiflora cream and oral metronidazole pill on results of treatments for vaginal infections including trichomoniasis and bacterial vaginosis in women of reproductive age. | effect of zataria multiflora on bacterial vaginosis and trichomonas vaginalis is shown in vivo and in vitro. we compare the effectiveness of zataria multiflora cream and oral metronidazole pill on results of treatment for vaginal infections including trichomonas and bacterial vaginosis; these infections occur simultaneously. the study included 420 women with bacterial vaginosis, trichomonas vaginalis, or both infections together, who were randomly divided into six groups. criteria for diagnosis ... | 2015 | 26266260 |
| anti-retroviral lectins have modest effects on adherence of trichomonas vaginalis to epithelial cells in vitro and on recovery of tritrichomonas foetus in a mouse vaginal model. | trichomonas vaginalis causes vaginitis and increases the risk of hiv transmission by heterosexual sex, while tritrichomonas foetus causes premature abortion in cattle. our goals were to determine the effects, if any, of anti-retroviral lectins, which are designed to prevent heterosexual transmission of hiv, on adherence of trichomonas to ectocervical cells and on tritrichomonas infections in a mouse model. we show that trichomonas asn-linked glycans (n-glycans), like those of hiv, bind the manno ... | 2015 | 26252012 |
| trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues. | trichomonas vaginalis (tv) is likely the most common non-viral sexually transmitted infection (sti) in the world. it is as an important source of reproductive morbidity, a facilitator of hiv transmission and acquisition, and thus it is an important public health problem. despite its importance in human reproductive health and hiv transmission, it is not a reportable disease and surveillance is not generally done. this is problematic since most persons infected with tv are asymptomatic. metronida ... | 2015 | 26242185 |
| medical devices; immunology and microbiology devices; classification of trichomonas vaginalis nucleic acid assay. final order. | the food and drug administration (fda) is classifying a trichomonas vaginalis nucleic acid assay into class ii (special controls). the agency is classifying the device into class ii (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device. | 2015 | 26241999 |
| effect of verbascum thapsus ethanol extract on induction of apoptosis in trichomonas vaginalis in vitro. | trichomoniasis is a sexually transmitted disease (std) caused by a tiny parasite called trichomonas vaginalis. metronidazole is used as routine treatment of disease. some reports have confirmed the potential carcinogenic and teratogenic effects of this drug on fetus and indication of drug resistance. verbascum thapsus belongs to the family of scorphulariaceae. its antiinflammatory properties, disinfectant and skin healing effects are well known. this plant has been used to treat diarrhea and gen ... | 2015 | 26239850 |
| value of bacterial culture of vaginal swabs in diagnosis of vaginal infections. | vaginal and cervical swab culture is still very common procedure in our country's everyday practice whereas simple and rapid diagnostic methods have been very rarely used. the aim of this study was to show that the employment of simple and rapid diagnostic tools [vaginal fluid wet mount microscopy (vfwmm), vaginal ph and potassium hydroxide (koh) test] offers better assessment of vaginal environment than standard microbiologic culture commonly used in serbia. | 2015 | 26226725 |
| polyamine quinoline rhodium complexes: synthesis and pharmacological evaluation as antiparasitic agents against plasmodium falciparum and trichomonas vaginalis. | a series of mono- and bis-salicylaldimine ligands and their corresponding rh(i) complexes were prepared. the compounds were characterised using standard spectroscopic techniques including nmr, ir spectroscopy and mass spectrometry. the salicylaldimine ligands and complexes were screened for antiparasitic activity against two strains of plasmodium falciparum i.e. the nf54 cq-sensitive and k1 cq-resistant strain as well as against the g3 isolate of trichomonas vaginalis. the monomeric salicylaldim ... | 2015 | 26226082 |
| persistence of trichomonas vaginalis serostatus in men over time. | previous epidemiologic studies have observed positive associations between trichomonas vaginalis (tv) serostatus and both prostate cancer (pca) risk and mortality. however, only a few small older studies have examined tv antibody persistence over time, all of which were composed mainly of female patients. therefore, we examined tv antibody persistence over time, as well as intra-individual variability, among middle- to older-aged men in the southern community cohort study (sccs). | 2015 | 26223890 |
| management of non-gonococcal urethritis. | non-gonococcal urethritis (ngu), or inflammation of the urethra, is the most common treatable sexually transmitted syndrome in men, with approximately 20-50 % of cases being due to infection with chlamydia trachomatis and 10-30 % mycoplasma genitalium. other causes are ureaplasma urealyticum, trichomonas vaginalis, anaerobes, herpes simplex virus (hsv) and adenovirus. up to half of the cases are non-specific. urethritis is characterized by discharge, dysuria and/or urethral discomfort but may be ... | 2015 | 26220178 |
| nitric oxide maintains cell survival of trichomonas vaginalis upon iron depletion. | iron plays a pivotal role in the pathogenesis of trichomonas vaginalis, the causative agent of highly prevalent human trichomoniasis. t. vaginalis resides in the vaginal region, where the iron concentration is constantly changing. hence, t. vaginalis must adapt to variations in iron availability to establish and maintain an infection. the free radical signaling molecules reactive oxygen species (ros) and reactive nitrogen species (rns) have been proven to participate in iron deficiency in eukary ... | 2015 | 26205151 |
| large two-centre study into the prevalence of mycoplasma genitalium and trichomonas vaginalis in the netherlands. | mycoplasma genitalium and trichomonas vaginalis are common sexually transmitted infections (stis). in the netherlands, testing for m. genitalium and t. vaginalis is not recommended for first-line sti screening. recent reports about the increasing antimicrobial resistance in m. genitalium raise concern about the adequacy of current empirical treatment regimens. it is necessary to have insight in the prevalence of m. genitalium and t. vaginalis in order to evaluate current first-line sti screening ... | 2016 | 26199286 |
| mucosal blood group antigen expression profiles and hiv infections: a study among female sex workers in kenya. | the abo blood group antigens are carbohydrate moieties expressed on human red blood cells however; these antigens can also be expressed on some other cells particularly the surface of epithelial cells and may be found in mucosal secretions. in many human populations 80% secrete abo antigens (termed 'secretors') while 20% do not (termed 'non-secretors'). furthermore, there are disease conditions that are associated with secretor status. | 2015 | 26186209 |
| high rates of double-stranded rna viruses and mycoplasma hominis in trichomonas vaginalis clinical isolates in south brazil. | trichomonas vaginalis is the etiological agent of trichomoniasis, the most common non-viral sexually transmitted disease (std) in world, with 276.4 million new cases each year. t. vaginalis can be naturally infected with mycoplasma hominis and trichomonasvirus species. this study aimed to evaluate the prevalence of t. vaginalis infected with four distinct t. vaginalis viruses (tvvs) and m. hominis among isolates from patients in porto alegre city, south brazil. an additional goal of this study w ... | 2015 | 26160539 |
| human papillomavirus positivity in women undergoing intrauterine insemination has a negative effect on pregnancy rates. | sexually transmitted infections are a major cause of infertility. human papillomavirus (hpv) infection is one of the most common viral infections of the female genital tract. only a limited number of studies have investigated the influence of hpv on fertility and its impact remains controversial. | 2016 | 26160018 |
| [possibility for luminescence identification of different trichomonas vaginalis forms]. | the paper presents the results of examining the morphology of different forms of trichomonas vaginalis by indirect immunofluorescence. fluorescence microscopy revealed that the typical forms of vaginal trichomonads showed a very bright light green glow, around the periphery of a cell in particular; the atypical forms of trichomonads emitted in the green spectral region less brilliantly and evenly. trichomonas fluorescence intensity was measured by spectrofluorescence assay. the experimental find ... | 2015 | 26152037 |
| prevalence of trichomonas vaginalis infection in symptomatic and asymptomatic women in central vietnam. | the diffusion of trichomoniasis in vietnam has been scarcely studied. the aim of this study was to investigate the prevalence of trichomoniasis in a group of symptomatic and asymptomatic women in central vietnam. relationships between education, socioeconomical and marital status, and sexual behavior with infection have also been investigated. | 2015 | 26142677 |
| synthetic sirnas effectively target cystein protease 12 and α-actinin transcripts in trichomonas vaginalis. | the flagellated protozoan trichomonas vaginalis (t. vaginalis) causes trichomoniasis, a reproductive tract infection, in humans. trichomoniasis is the most common non-viral sexually transmitted disease worldwide. in addition to direct consequences such as infertility and abortion, there are indications that trichomoniasis favours development of prostate cancer and it has also been associated with increased risk of spreading human immunodeficiency virus and papillomavirus infections. reports from ... | 2015 | 26134763 |
| rna biosignatures in adolescent patients in a pediatric emergency department with pelvic inflammatory disease. | adolescents are at high risk for pelvic inflammatory disease (pid). because accurate diagnosis of pid is difficult, and complications of untreated pid are significant, novel methods to improve diagnosis are essential. | 2015 | 26125533 |
| changes in the contribution of genital tract infections to hiv acquisition among kenyan high-risk women from 1993 to 2012. | the objective of this study was to understand temporal trends in the contribution of different genital tract infections to hiv incidence over 20 years of follow-up in a cohort of high-risk women. | 2015 | 26125141 |
| cytomorphometric and morphological analysis in women with trichomonas vaginalis infection: micronucleus frequency in exfoliated cervical epithelial cells. | the aim of this study was to explore the cytomorphometric and morphological effects of trichomonas vaginalis in exfoliated epithelial cells. | 2015 | 26112451 |
| trypanocidal, trichomonacidal and cytotoxic components of cultivated artemisia absinthium linnaeus (asteraceae) essential oil. | artemisia absinthium is an aromatic and medicinal plant of ethnopharmacological interest and it has been widely studied. the use ofa. absinthium based on the collection of wild populations can result in variable compositions of the extracts and essential oils (eos). the aim of this paper is the identification of the active components of the vapour pressure (vp) eo from a selected and cultivated a. absinthium spanish population (t2-11) against two parasitic protozoa with different metabolic pathw ... | 2015 | 26107187 |
| p transposable elements in drosophila and other eukaryotic organisms. | p transposable elements were discovered in drosophila as the causative agents of a syndrome of genetic traits called hybrid dysgenesis. hybrid dysgenesis exhibits a unique pattern of maternal inheritance linked to the germline-specific small rna piwi-interacting (pirna) pathway. the use of p transposable elements as vectors for gene transfer and as genetic tools revolutionized the field of drosophila molecular genetics. p element transposons have served as a useful model to investigate mechanism ... | 2015 | 26104714 |
| genetic diversity of trichomonas vaginalis clinical isolates from henan province in central china. | trichomonas vaginalis is a flagellated protozoan parasite that infects the human urogenital tract, causing the most common non-viral, sexually transmitted disease worldwide. in this study, genetic variants of t. vaginalis were identified in henan province, china. fragments of the small subunit of nuclear ribosomal rna (18s rrna) were amplified from 32 t. vaginalis isolates obtained from seven regions of henan province. overall, 18 haplotypes were determined from the 18s rrna sequences. each samp ... | 2015 | 26103990 |
| trichomonas vaginalis cysteine proteinases: iron response in gene expression and proteolytic activity. | we focus on the iron response of trichomonas vaginalis to gene family products such as the cysteine proteinases (cps) involved in virulence properties. in particular, we examined the effect of iron on the gene expression regulation and function of cathepsin l-like and asparaginyl endopeptidase-like cps as virulence factors. we addressed some important aspects about cps genomic organization and we offer possible explanations to the fact that only few members of this large gene family are expresse ... | 2015 | 26090464 |
| diagnosis and treatment of bacterial prostatitis. | prostate inflammation is a common syndrome, especially in men under 50. it usually presents with voiding symptoms and pain in the genitourinary area, and sometimes as sexual dysfunction. based on clinical and laboratory characteristics, prostatitis is classified as acute bacterial prostatitis, chronic bacterial prostatitis, chronic inflammatory and non-inflammatory prostatitis or chronic pelvic pain syndrome, and asymptomatic inflammatory prostatitis. bacterial prostatitis is most often caused b ... | 2015 | 26086164 |
| t. vaginalis infection is associated with increased il-8 and tnfr1 levels but with the absence of cd38 and hladr activation in the cervix of esn. | trichomonas vaginalis infection is associated with an increased risk of hiv infection in exposed-seronegative women (esn) despite their unique immune quiescent profile. it is important to understand possible mechanisms, such as recruitment of activated t cells, by which t. vaginalis could facilitate hiv infection in this population. | 2015 | 26083468 |
| comparison between mixed lysate antigen and α-actinin antigen in elisa for serodiagnosis of trichomoniasis. | the aim of this study was to identify an antigen suitable for elisa for serodiagnosis of trichomonas vaginalis (t. vaginalis) infection. mixed lysate antigen (ag) from eight strains of t. vaginalis and recombinant α-actinin protein was compared. the sera of three groups were examined by elisa: 73 women infected with trichomoniasis served as a positive control, 31 male volunteers as a negative control, and 424 women attending an outpatient health screening at hanyang university guri hospital. bas ... | 2015 | 26072305 |
| the incidence of trichomonas vaginalis infection in women attending nine sexually transmitted diseases clinics in the usa. | trichomoniasis (tv) is associated with an increased risk of acquisition of sexually transmitted diseases (stds) and hiv. the purpose of this study is to evaluate factors associated with incidence tv among female std clinic attendees in the usa. | 2016 | 26071390 |
| overdiagnosis of urinary tract infection and underdiagnosis of sexually transmitted infection in adult women presenting to an emergency department. | urinary tract infections (utis) and sexually transmitted infections (stis) are commonly diagnosed in emergency departments (eds). distinguishing between these syndromes can be challenging because of overlapping symptomatology and because both are associated with abnormalities on urinalysis (ua). we conducted a 2-month observational cohort study to determine the accuracy of clinical diagnoses of uti and sti in adult women presenting with genitourinary (gu) symptoms or diagnosed with gu infections ... | 2015 | 26063863 |
| characteristics of women enrolled into a randomized clinical trial of dapivirine vaginal ring for hiv-1 prevention. | women in sub-saharan africa are a priority population for evaluation of new biomedical hiv-1 prevention strategies. antiretroviral pre-exposure prophylaxis is a promising prevention approach; however, clinical trials among young women using daily or coitally-dependent products have found low adherence. antiretroviral-containing vaginal microbicide rings, which release medication over a month or longer, may reduce these adherence challenges. | 2015 | 26061040 |
| population structure and genetic diversity of the parasite trichomonas vaginalis in bristol, uk. | the protozoan parasite trichomonas vaginalis is the causative agent of trichomoniasis, an extremely common, but non-life-threatening, sexually-transmitted disease throughout the world. recent population genetics studies of t. vaginalis have detected high genetic diversity and revealed a two-type population structure, associated with phenotypic differences in sensitivity to metronidazole, the drug commonly used for treatment, and presence of t. vaginalis virus. there is currently a lack of data o ... | 2015 | 26051885 |
| prevalence of the genital tract bacterial infections after vaginal reconstructive surgery. | due to frequent childbirth, heavy lifting and the structure of the lives of rural women in shahrekord region, iran, cystocele and rectocele are of the main medical problems of the women in this area and for its correction, vaginal reconstructive surgery is needed which causes infection. the purpose of this study was to identify the bacteria causing infection after vaginal reconstructive surgery and performing antibiogram to help these patients for faster recovery. patients enrolled this study we ... | 2014 | 26031026 |
| rho gtpases as pathogen targets: focus on curable sexually transmitted infections. | pathogens have evolved highly specialized mechanisms to infect hosts. several microorganisms modulate the eukaryotic cell surface to facilitate their engulfment. once internalized, they hijack the molecular machinery of the infected cell for their own benefit. at different stages of phagocytosis, particularly during invasion, certain pathogens manipulate pathways governed by small gtpases. in this review, we focus on the role of rho proteins on curable, sexually transmitted infections caused by ... | 2015 | 26023809 |
| prevalence of trichomoniasis among women in kermanshah, iran. | trichomoniasis, caused by trichomonas vaginalis, is the most common sexually transmitted disease (std) in the world with estimates of 7-8 million infections annually in the united states and 180 million globally. | 2015 | 26019904 |
| evaluating hiv prevention programs: herpes simplex virus type 2 antibodies as biomarker for sexual risk behavior in young adults in resource-poor countries. | measuring effectiveness of hiv prevention interventions is challenged by bias when using self-reported knowledge, attitude or behavior change. hiv incidence is an objective marker to measure effectiveness of hiv prevention interventions, however, because new infection rates are relatively low, prevention studies require large sample sizes. herpes simplex virus type 2 (hsv-2) is similarly transmitted and more prevalent and could thus serve as a proxy marker for sexual risk behavior and therefore ... | 2015 | 26010772 |
| vulvovaginitis: screening for and management of trichomoniasis, vulvovaginal candidiasis, and bacterial vaginosis. | to review the evidence and provide recommendations on screening for and management of vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis. | 2015 | 26001874 |
| synthesis and antiprotozoal activity of mono- and bis-uracil isatin conjugates against the human pathogen trichomonas vaginalis. | a library of mono- and bis-uracil isatin conjugates were synthesized and subjected for the assessment of their in vitro activity against the protozoal pathogen trichomonas vaginalis. the structure activity studies (sar) revealed that the bis-uracil-isatin based conjugates were more effective than their corresponding mono conjugates in inhibiting the growth of t. vaginalis at approximately 10 μm with no visual effect on mammalian cells at the same concentration. | 2015 | 25999204 |
| sequestration of host-cd59 as potential immune evasion strategy of trichomonas vaginalis. | trichomonas vaginalis is known to evade complement-mediated lysis. because the genome of t. vaginalis does not possess dna sequence with homology to human protectin (cd59), a complement lysis restricting factor, we tested the hypothesis that host cd59 acquisition by t. vaginalis organisms mediates resistance to complement killing. this hypothesis was based on the fact that trichomonads are known to associate with host proteins. no cd59 was detected on the surface of t. vaginalis grown in serum-b ... | 2015 | 25976413 |
| the role of chlamydia trachomatis in high-risk human papillomavirus persistence among female sex workers in nairobi, kenya. | little is known about risk factors for persistent high-risk human papillomavirus (hrhpv) infection in low-income settings, and prior research has not quantified the relative duration of hrhpv infections stratified by risk factors. we compared the duration of hrhpv infection among female sex workers (fsws) by exposure to sexually transmitted infections (stis), using a highly sensitive biomarker assay. | 2015 | 25970306 |
| anti-trichomonas vaginalis properties of the oil of amomum tsao-ko and its major component, geraniol. | trichomonosis, caused by the flagellate protozoan trichomonas vaginalis, is the most common non-viral sexually transmitted disease (std) and 5-nitroimidazole drugs are used for the treatment. however, a growing number of t. vaginalis isolates are resistant to these drugs, which make it becomes an urgent issue. | 2016 | 25963227 |
| prevalence and correlates of trichomonas vaginalis infection among female sex workers in a city in yunnan province, china. | sexual transmission is the fastest growing route of hiv transmission in china, and trichomonas vaginalis(tv) can facilitate hiv transmission and acquisition. our goal was to determine the prevalence and correlates of tv infection among female sex workers (fsws). this cross-sectional study was conducted in a city of yunnan province in southern china, with confidential face-to-face interviews and laboratory tests for tv (wet mount) and other sexually transmitted infections. a total of 734 fsws par ... | 2016 | 25957327 |
| utility of microbiological profile of symptomatic vaginal discharge in rural women of reproductive age group. | symptomatic vaginal discharge is the most frequent symptom in women of reproductive age group. owing to social stigma majority of affected women hesitate to seek medical consultation. therefore the actual incidence of vaginal discharge is much more than what is reported. the aim of the study is to determine the microbiological profile of symptomatic vaginal discharge in rural area and its utility in the management of genital tract infection. | 2015 | 25954668 |
| diagnostic value of the papanicolaou smear in lower genital tract infections during pregnancy. | to evaluate the diagnostic value of the pap smear in lower genital tract infections during pregnancy. | 2000 | 25951154 |
| iron from haemoglobin and haemin modulates nucleotide hydrolysis in trichomonas vaginalis. | extracellular atp may act as a danger signalling molecule, inducing inflammation and immune responses in infection sites. the ectonucleotidases ntpdase and ecto-5'-nucleotidase are enzymes that modulate extracellular nucleotide levels; these enzymes have been previously characterised in trichomonas vaginalis. iron plays an important role in the complex trichomonal pathogenesis. herein, the effects of iron on growth, nucleotide hydrolysis and ntpdase gene expression in t. vaginalis isolates from ... | 2015 | 25946243 |
| the efficacy of 2-nitrovinylfuran derivatives against leishmania in vitro and in vivo. | despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and cost. the wide-spectrum antimicrobial activity of 2-nitrovinylfuran compounds has been described, as has their activity against trichomonas vaginalis and other protozoa. thus, the aim of this study was to test the antileishmanial activities of six 2-nitrovinylfurans in vitro and in a murine model of leishmaniasis. minimum paras ... | 2015 | 25946239 |
| detection of mycoplasma genitalium from male primary urine specimens: an epidemiologic dichotomy with trichomonas vaginalis. | a total of 2750 male urines subjected to a transcription-mediated amplification (tma)-based mycoplasma genitalium assay yielded 188 positive results (6.84%). this rate was similar to chlamydia trachomatis (6.87%; p = 0.96) and greater than neisseria gonorrhoeae (4.0%) and trichomonas vaginalis (2.3%; p < 0.0002). mean age of m. genitalium-infected males (30.8) was similar to n. gonorrhoeae (p = 0.78) but less than t. vaginalis (mean, 41.6; p < 0.0001). a total of 266 sti clinic encounters had at ... | 2015 | 25934156 |
| comparison of substance use typologies as predictors of sexual risk outcomes in african american adolescent females. | african american female adolescents have a disproportionate risk of sexually transmitted infections (stis) and other adverse sexual health outcomes. both alcohol and marijuana use have been shown to predict sexual risk among young african american women. however, no studies have attempted to differentiate alcohol and marijuana typologies use as predictors of sexual risk outcomes exclusively among adolescents who use these substances. this study compared recent alcohol and/or marijuana use as pre ... | 2016 | 25929200 |
| female reproductive hormones and biomarkers of oxidative stress in genital chlamydia infection in tubal factor infertility. | genital chlamydia infection (gci) and the associated pathologies have been implicated in tubal infertility. though the actual pathologic mechanisms are still uncertain, oxidative stress and other factors have been implicated. the purpose of the study was to determine the possible contribution of female reproductive hormones and biomarkers of oxidative stress in genital chlamydial infection to tubal occlusion. | 2015 | 25927024 |
| epidemiology and treatment of trichomoniasis. | trichomonas vaginalis is the most common nonviral sexually transmitted infection (sti) in the world. it was once thought to be a nuisance sti, but it is now being recognized as an important source of reproductive morbidity and a facilitator of hiv transmission and acquisition, and thus it is an important public health problem. the prevalence of t. vaginalis varies greatly by geography and risk group, but is more common among persons of african descent and appears to increase with age, though thi ... | 2015 | 25925796 |
| antenatal lower genital tract infection screening and treatment programs for preventing preterm delivery. | genital tract infection is associated with preterm birth (before 37 weeks' gestation). screening for infections during pregnancy may therefore reduce the numbers of babies being born prematurely. however, screening for infections may have some adverse effects, such as increased antibiotic drug resistance and increased cost of treatment. | 2015 | 25922860 |
| the pathogenesis of human cervical epithelium cells induced by interacting with trichomonas vaginalis. | trichomonas vaginalis is a protozoan parasite that occurs in the urogenital-vaginal tract and is the primary causative agent of trichomoniasis, a common sexually transmitted disease in humans. the aggregation of this protozoan tends to destroy epithelial cells and induce pathogenesis. | 2015 | 25901354 |
| a sexually transmitted infection screening algorithm based on semiparametric regression models. | sexually transmitted infections (stis) with chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis are among the most common infectious diseases in the united states, disproportionately affecting young women. because a significant portion of the infections present no symptoms, infection control relies primarily on disease screening. however, universal sti screening in a large population can be expensive. in this paper, we propose a semiparametric model-based screening algorithm. ... | 2015 | 25900920 |
| papanicolaou smear findings in solid-organ transplant recipients compared with normal subjects according to the bethesda 2001 system. | solid-organ transplant recipients are at increased risk of developing cancer including cervical cancer compared with woman in the general population, mostly due to long-term immunosuppressive therapy. the papanicolaou smear remains the primary method of screening cervical pathology including preinvasive and invasive lesions. the objective of this study was to evaluate pap smear findings in solid-organ transplant recipients, determine the prevalence of abnormal smears, and compare these patients ... | 2015 | 25894158 |
| p transposable elements in drosophila and other eukaryotic organisms. | p transposable elements were discovered in drosophila as the causative agents of a syndrome of genetic traits called hybrid dysgenesis. hybrid dysgenesis exhibits a unique pattern of maternal inheritance linked to the germline-specific small rna piwi-interacting (pirna) pathway. the use of p transposable elements as vectors for gene transfer and as genetic tools revolutionized the field of drosophila molecular genetics. p element transposons have served as a useful model to investigate mechanism ... | 2015 | 25893144 |
| kinetics of circulating antibody response to trichomonas vaginalis: clinical and diagnostic implications. | persistence of antibodies against pathogens after antimicrobial treatment is a marker of therapy failure or evolution to a chronic infection. the kinetics of antibody production decrease following antigen elimination is highly variable, and predicting the duration of soluble immunity in infectious diseases is often impossible. this hampers the development and use of immunoassays for diagnostic and seroepidemiological purposes. in the case of trichomonas vaginalis infection, the kinetics of antib ... | 2015 | 25887282 |
| prevalence of mycoplasma genitalium and mycoplasma hominis in urogenital tract of brazilian women. | the role of mycoplasma hominis and m. genitalium in urogenital tract infections remains unknown. furthermore these mollicutes present a complex relationship with the host immune response. the role of inflammatory cytokines in infections also makes them good candidates to investigate bacterial vaginosis and mycoplasma genital infections. therefore, the aim of this study was to detect the above-mentioned mollicutes by quantitative polymerase chain reaction (qpcr) methodologies in vaginal swabs and ... | 2015 | 25886914 |